@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : M_NR1H4_FXR: (2016-04-07 )
MVMQFQGLENPIQISLHHSHRLSGFVPDGMSVKPAKGMLTEHAAGPLGQNLDLESYSPYNNVPFPQVQPQISSSSYYSNLGFYPQQPEDWYSPGIYELRRMPAETGYQGETEVSEMPVTKKPRMAAASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLRKCREMGMLAECMYTGLLTEIQCKSKRLRKNVKQHADQTVNEDDSEGRDLRQVTSTTKFCREKTELTADQQTLLDYIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATSHVQILVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPAGHADLLEERIRKSGISDEYITPMFSFYKSVGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKMYQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLCEIWDVQ
Atome Classification :
(40 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
V
M
QFQGLEN
P
I
Q
I
S
L
HHSHRLSGFVPDGMSVKPAKG
M
L
T
EHAAGPLGQNLDLESYSPYNNVPFPQVQPQISSSSYYSNLGFYPQQPEDWYS
P
G
I
Y
E
L
R
RMPAETGYQGETEVSEMPVTKKPRMAAASAGRIKG
D
E
L
C
V
V
CGDRASG
Y
H
YN
A
L
T
C
E
G
C
K
G
F
F
R
R
SITKN
A
V
Y
KCKNGG
N
C
V
M
D
M
Y
M
R
R
K
C
Q
E
C
R
L
R
K
C
R
E
M
G
M
L
A
E
C
M
Y
T
G
L
L
T
E
I
Q
C
K
S
K
R
L
R
K
N
V
K
Q
H
A
DQTVNEDDSEG
R
D
L
R
Q
V
T
S
T
T
K
F
C
R
E
K
T
ELTA
D
Q
Q
T
L
L
D
Y
I
M
D
SYNKQRM
P
Q
E
I
T
N
K
I
L
K
E
E
FSAEE
N
F
L
I
L
T
E
M
A
T
S
H
V
Q
I
L
V
E
F
T
K
KLPGFQTLDHED
Q
I
A
L
LKGS
A
V
E
A
M
F
L
R
S
A
E
I
F
NKKLPAG
H
A
D
L
L
E
E
R
I
R
KSGISDEYI
T
P
M
F
S
F
Y
K
S
V
G
ELKM
T
Q
E
E
Y
A
L
L
T
A
I
V
I
LSP
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
MYQPEN
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
TF
N
H
H
H
A
E
M
L
M
S
WRVNDHKFT
P
L
L
C
E
IWDVQ
27
PsiBlast_CBE
96.72
94%
-128
- C2 -
3OOF
1
C:
[5-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
A
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
A
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
26
PsiBlast_CBE
96.52
94%
-127
- C2 -
3OOK
1
NR1H4_HUMAN
A:
[5-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
A
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
A
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
18
PsiBlast_PDB
95.98
94%
-124
- C2 -
3OLF
1
NR1H4_HUMAN
A:
[5-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
A
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
A
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
30
PsiBlast_CBE
95.88
94%
-129
- C2 -
3OMK
1
C:
[5-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
A
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
A
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
17
PsiBlast_PDB
95.86
94%
-125
- C2 -
3OKI
1
NR1H4_HUMAN
A:
[5-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
A
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
A
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
20
PsiBlast_PDB
95.85
94%
-127
- C2 -
3OMM
1
NR1H4_HUMAN
A:
[5-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
A
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
A
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
19
PsiBlast_PDB
95.49
94%
-127
- C2 -
3OMK
1
NR1H4_HUMAN
A:
[5-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
A
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
A
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
31
PsiBlast_CBE
95.38
94%
-127
- C2 -
3OLF
1
C:
[5-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
A
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
A
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
28
PsiBlast_CBE
95.38
94%
-123
- C2 -
3OOF
1
NR1H4_HUMAN
A:
[5-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
A
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
A
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
25
PsiBlast_CBE
95.34
94%
-128
- C2 -
3OOK
1
C:
[5-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
A
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
A
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
29
PsiBlast_CBE
95.20
94%
-126
- C2 -
3OMM
1
C:
[5-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
A
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
A
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
32
PsiBlast_CBE
94.35
94%
-126
- C2 -
3OKI
1
C:
[5-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
A
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
A
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
13
PsiBlast_PDB
94.04
95%
-136
- C2 -
1OSH
1
A:
[4-231]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
---------------
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
-
6
PsiBlast_PDB
93.57
95%
-126
- C2 -
3HC5
1
A:
[4-232]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
16
PsiBlast_PDB
93.50
94%
-129
- C2 -
3OKH
2
A:
[5-232]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
A
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
A
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
-
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
-
11
PsiBlast_PDB
93.37
95%
-124
- C2 -
4QE6
2
?
A:
[5-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
---
S
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
10
PsiBlast_PDB
93.35
95%
-123
- C2 -
3RUU
1
A:
[1-229]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
14
PsiBlast_PDB
93.23
95%
-131
- C2 -
3L1B
1
A:
[5-232]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
---------------
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
-
21
PsiBlast_CBE
93.12
94%
-125
- C2 -
3BEJ
1
B:
[10-237]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
-
8
PsiBlast_PDB
93.07
94%
-133
- C2 -
3FLI
1
A:
[3-230]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
-------
F
T
P
L
L
C
E
I
W
D
V
-
22
PsiBlast_CBE
92.78
97%
-123
- C2 -
1OSV
1
B:
[1-229]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
T
V
D
Q
Q
T
L
L
D
Y
I
M
D
S
Y
S
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
S
H
V
Q
I
L
V
E
F
T
K
R
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
A
G
H
A
D
L
L
E
E
R
I
R
K
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
V
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
Y
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
-
1
PsiBlast_PDB
92.64
94%
-126
- C2 -
3BEJ
1
NR1H4_HUMAN
A:
[11-237]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
---
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
-
4
PsiBlast_PDB
92.63
95%
-123
- C2 -
3DCT
1
A:
[7-235]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
2
PsiBlast_PDB
92.50
97%
-124
- C2 -
1OSV
1
NR1H4_RAT
A:
[1-229]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
T
V
D
Q
Q
T
L
L
D
Y
I
M
D
S
Y
S
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
S
H
V
Q
I
L
V
E
F
T
K
R
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
A
G
H
A
D
L
L
E
E
R
I
R
K
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
V
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
Y
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
-
35
PsiBlast_CBE
92.48
94%
-121
- C2 -
3GD2
1
A:
[3-229]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
-
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
-
K
L
P
S
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
E
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
E
E
I
W
D
V
Q
5
PsiBlast_PDB
92.45
95%
-121
- C2 -
3DCU
1
A:
[7-235]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
9
PsiBlast_PDB
92.03
95%
-117
- C2 -
3RUT
1
A:
[1-229]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
3
PsiBlast_PDB
91.73
98%
-116
- C2 -
1OT7
1
NR1H4_RAT
A:
[1-229]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
L
T
V
D
Q
Q
T
L
L
D
Y
I
M
D
S
Y
S
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
S
H
V
Q
I
L
V
E
F
T
K
R
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
A
G
H
A
D
L
L
E
E
R
I
R
K
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
V
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
Y
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
-
23
PsiBlast_CBE
91.69
98%
-121
- C2 -
1OT7
1
B:
[1-229]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
L
T
V
D
Q
Q
T
L
L
D
Y
I
M
D
S
Y
S
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
S
H
V
Q
I
L
V
E
F
T
K
R
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
A
G
H
A
D
L
L
E
E
R
I
R
K
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
V
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
Y
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
-
24
PsiBlast_CBE
91.53
95%
-123
- C2 -
4QE8
4
?
B:
[5-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
--
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
-----
K
F
T
P
L
L
C
E
I
W
D
V
Q
36
PsiBlast_CBE
91.39
93%
-121
- C2 -
3P88
1
A:
[1-229]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
E
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
E
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
E
E
I
W
D
V
Q
7
PsiBlast_PDB
90.92
95%
-123
- C2 -
3RVF
1
A:
[5-232]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
15
PsiBlast_PDB
90.85
94%
-132
- C2 -
3FXV
1
A:
[5-232]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
A
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
-----
H
S
D
L
L
E
A
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
--
H
K
F
T
P
L
L
C
E
I
W
D
V
-
33
PsiBlast_CBE
90.22
94%
-116
- C2 -
3HC6
1
A:
[3-232]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
E
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
E
E
I
W
D
V
Q
12
PsiBlast_PDB
90.03
95%
-124
- C2 -
4QE8
5
?
A:
[5-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
--
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
----
K
F
T
P
L
L
C
E
I
W
D
V
Q
34
PsiBlast_CBE
88.31
94%
-124
- C2 -
3P89
1
A:
[4-228]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
--
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
E
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
E
E
I
W
D
V
-
38
PsiBlast_CBE
88.02
94%
-129
- C2 -
4OIV
1
NR1H4_HUMAN
A:
[1-226]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
----------------
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
E
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
E
E
I
W
---
37
PsiBlast_CBE
86.73
94%
-120
- C2 -
4OIV
1
B:
[1-226]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
-------
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
E
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
-
T
P
L
L
E
E
I
W
---
40
PsiBlast_CBE
79.99
94%
-112
- C2 -
4WVD
1
NR1H4_HUMAN
A:
[1-211]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
-
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
------------------
39
PsiBlast_CBE
79.32
94%
-109
- C2 -
4WVD
1
B:
[2-211]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
E
R
I
R
N
S
--
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
------------------