@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : M_NR2B2_RXRB: (2016-04-07 )
MSWATRPPFLPPRHAAGQCGPVGVRKEMHCGVASRWRRRRPWLDPAAAAAAAGEQQALEPEPGEAGRDGMGDSGRDSRSPDSSSPNPLSQGIRPSSPPGPPLTPSAPPPPMPPPPLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGSGPPEDVKPPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGDGAGGAPEEMPVDRILEAELAVEQKSDQGVEGPGATGGGGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPGEVEILREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQLA
Atome Classification :
(77 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180......--.190.......200.......210.......220.......230.......240.......250.......260.......270.-......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.........---------------390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSWATRPPFLPPRHAAGQCGPVG
V
R
K
E
M
H
C
G
V
A
S
R
W
R
RRRPWL
D
P
A
A
A
AAAAGEQQALEPEPGEAGRDGMGDSGRDSRSPDSSSPN
P
L
SQGIRPSSPPGPPLTPSAPPPPMPPPPLGSPF
P
V
I
SSSMGSPGLPPPAPPGFSGPVSSPQIN
S
T
V
SLPGGGSGPPEDVKPPVLGVRGLHCPPPPGGPGAG--
K
R
L
C
A
ICGDRSSGKHY
G
V
Y
SCE
G
C
K
G
F
F
K
R
T
I
R
K
D
L
T
YSCRDNKDC
T
V
D
K
R
Q
R
N
R
C
Q
Y
C
R
Y
Q
K
C
L
A
TG
M
K
R
E
A
V
Q
E
E
R
Q
RGKDKD-GDGDGAGGAPEEM
P
V
D
R
I
L
E
A
E
L
A
V
EQKSDQGVEGPGATGGGGSSPN
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
RIPHFSSLPLDD
Q
V
I
L
L
RAGWN
E
L
L
I
A
SFSHR
S
I
DVRD--
G
I
L
L
A
T
G
L
H
---------------
V
HRNSAHSA
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
MRM
D
K
T
E
L
G
C
L
R
A
I
I
L
FNPDAKGLSNP
G
E
V
E
I
L
R
E
K
V
Y
A
S
L
E
T
Y
C
K
QKY
P
E
QQ
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
IGDT
P
I
D
T
F
L
M
E
M
L
EAPHQLA
21
PsiBlast_CBE
86.73
82%
-111
- C2 -
4NQA
1
?
H:
[30-361]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
S
FT
K
H
I
C
A
I
C
G
D
R
S
S
G
K
H
Y
G
V
Y
S
C
E
G
C
K
G
F
F
K
R
T
V
R
K
D
L
T
Y
T
C
R
D
N
K
D
C
L
I
D
K
R
Q
R
N
R
C
Q
Y
C
R
Y
Q
K
C
L
A
M
G
M
K
R
E
A
V
Q
E
E
R
Q
R
G
K
D
R
N
E
N
E
V
E
S
T
S
S
A
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
K
T
E
T
---------------
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
1
PsiBlast_PDB
85.15
77%
-121
- C2 -
3DZU
1
RXRA_HUMAN
A:
[137-460]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
I
C
A
I
C
G
D
R
S
S
G
K
H
Y
G
V
Y
S
C
E
G
C
K
G
F
F
K
R
T
V
R
K
D
L
T
Y
T
C
R
D
N
K
D
C
L
I
D
K
R
Q
R
N
R
C
Q
Y
C
R
Y
Q
K
C
L
A
M
G
M
K
R
E
A
V
Q
E
E
R
Q
R
--------------
A
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
-----------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
-------
3
PsiBlast_PDB
84.38
82%
-107
- C2 -
4NQA
1
RXRA_HUMAN
A:
[31-359]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
FT
K
H
I
C
A
I
C
G
D
R
S
S
G
K
H
Y
G
V
Y
S
C
E
G
C
K
G
F
F
K
R
T
V
R
K
D
L
T
Y
T
C
R
D
N
K
D
C
L
I
D
K
R
Q
R
N
R
C
Q
Y
C
R
Y
Q
K
C
L
A
M
G
M
K
R
E
A
V
Q
E
E
R
Q
R
G
-----------
S
S
A
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
K
T
E
T
Y
-
E
A
N
--
M
G
L
N
P
S
S
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
------
2
PsiBlast_PDB
81.68
77%
-120
- C2 -
3E00
1
RXRA_HUMAN
A:
[137-460]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
I
C
A
I
C
G
D
R
S
S
G
K
H
Y
G
V
Y
S
C
E
G
C
K
G
F
F
K
R
T
V
R
K
D
L
T
Y
T
C
R
D
N
K
D
C
L
I
D
K
R
Q
R
N
R
C
Q
Y
C
R
Y
Q
K
C
L
A
M
G
M
K
R
E
A
V
Q
E
E
R
Q
R
--------------
A
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
-----------------------
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
-------
4
PsiBlast_PDB
81.12
98%
-138
- C2 -
1UHL
1
A:
[1-231]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
P
V
D
R
I
L
E
A
E
L
A
V
E
Q
-----------------
S
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
S
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
D
V
R
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
R
M
D
K
T
E
L
G
C
L
R
A
I
I
L
F
N
P
D
A
K
G
L
S
N
P
S
E
V
E
V
L
R
E
K
V
Y
A
S
L
E
T
Y
C
K
Q
K
Y
P
E
Q
Q
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
-----
83
PsiBlast_CBE
79.55
88%
-135
- C2 -
3PCU
1
RXRA_HUMAN
A:
[1-230]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
---------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
15
PsiBlast_PDB
79.33
86%
-131
- C2 -
1MVC
1
RXRA_HUMAN
A:
[7-236]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
--------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
19
PsiBlast_PDB
78.81
86%
-132
- C2 -
2P1V
1
RXRA_HUMAN
A:
[7-236]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
---------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
81
PsiBlast_CBE
78.75
88%
-122
- C2 -
1XLS
1
RXRA_HUMAN
B:
[2-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
K
T
E
T
Y
V
E
A
--
N
M
G
L
N
P
S
S
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
69
PsiBlast_CBE
78.68
88%
-135
- C2 -
4RFW
1
?
A:
[1-231]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
-------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
14
PsiBlast_PDB
78.53
86%
-130
- C2 -
1MV9
1
RXRA_HUMAN
A:
[7-238]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
--------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
H
Q
--
43
PsiBlast_CBE
78.52
86%
-130
- C2 -
1MZN
1
RXRA_HUMAN
G:
[7-236]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
--------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
18
PsiBlast_PDB
78.52
86%
-136
- C2 -
2P1U
1
RXRA_HUMAN
A:
[7-236]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
---------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
67
PsiBlast_CBE
78.50
88%
-130
- C2 -
4RME
1
?
A:
[1-231]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
-------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
109
HHSearch
78.33
88%
-136
- C2 -
2P1T
1
RXRA_HUMAN
A:
[7-236]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
---------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
74
PsiBlast_CBE
78.25
88%
-132
- C2 -
4M8H
1
RXRA_HUMAN
A:
[1-231]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
-------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
7
PsiBlast_PDB
78.20
87%
-130
- C2 -
1RDT
1
RXRA_HUMAN
A:
[8-236]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
--------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
------
77
PsiBlast_CBE
78.17
88%
-134
- C2 -
4K4J
1
?
A:
[1-231]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
-------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
20
PsiBlast_PDB
78.14
86%
-132
- C2 -
3FUG
1
RXRA_HUMAN
A:
[7-236]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
---------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
45
PsiBlast_CBE
78.10
86%
-131
- C2 -
1MZN
1
RXRA_HUMAN
C:
[7-236]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
--------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
10
PsiBlast_PDB
78.09
86%
-134
- C2 -
3E94
1
RXRA_HUMAN
A:
[11-240]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
---------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
71
PsiBlast_CBE
78.00
88%
-132
- C2 -
4PP3
1
RXRA_HUMAN
A:
[1-231]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
-------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
17
PsiBlast_PDB
77.98
86%
-136
- C2 -
2P1T
1
RXRA_HUMAN
A:
[7-236]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
---------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
11
PsiBlast_PDB
77.78
86%
-136
- C2 -
3KWY
1
RXRA_HUMAN
A:
[11-240]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
--------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
--
I
D
T
F
L
M
E
M
L
E
A
P
----
72
PsiBlast_CBE
77.56
88%
-133
- C2 -
4POJ
1
RXRA_HUMAN
A:
[1-231]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
-------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
70
PsiBlast_CBE
77.54
88%
-133
- C2 -
4PP5
1
RXRA_HUMAN
A:
[1-231]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
-------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
30
PsiBlast_CBE
77.53
86%
-132
- C2 -
4N5G
1
?
C:
[13-240]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
E
R
I
L
E
A
E
L
A
---------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
68
PsiBlast_CBE
77.32
88%
-130
- C2 -
4RMC
1
?
A:
[1-231]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
-------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
9
PsiBlast_PDB
77.11
86%
-133
- C2 -
4OC7
1
RXRA_HUMAN
A:
[21-250]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
-------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
48
PsiBlast_CBE
77.04
87%
-135
- C2 -
3OZJ
1
RXRA_HUMAN
C:
[3-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
-------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
73
PsiBlast_CBE
76.92
88%
-134
- C2 -
4POH
1
RXRA_HUMAN
A:
[1-231]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
-------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
42
PsiBlast_CBE
76.92
86%
-134
- C2 -
2ZXZ
1
RXRA_HUMAN
A:
[7-236]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
-------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
59
PsiBlast_CBE
76.69
87%
-116
- C2 -
1FM6
1
RXRA_HUMAN
A:
[3-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
K
T
E
T
Y
V
E
A
N
--
M
G
L
N
P
S
S
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
49
PsiBlast_CBE
76.51
87%
-130
- C2 -
3OZJ
1
RXRA_HUMAN
A:
[3-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
-------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
75
PsiBlast_CBE
76.37
88%
-135
- C2 -
4M8E
1
RXRA_HUMAN
A:
[1-231]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
-------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
31
PsiBlast_CBE
76.29
86%
-134
- C2 -
3R5M
1
RXRA_HUMAN
C:
[6-236]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
--------------------
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
40
PsiBlast_CBE
76.28
86%
-128
- C2 -
2ZY0
1
RXRA_HUMAN
C:
[5-236]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
-------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
78
PsiBlast_CBE
76.25
88%
-131
- C2 -
3OAP
1
RXRA_HUMAN
A:
[1-231]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
-------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
84
PsiBlast_CBE
76.04
87%
-128
- C2 -
1DKF
1
RXRA_MOUSE
A:
[1-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
N
E
D
M
P
V
E
K
I
L
E
A
E
L
A
V
E
P
------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
A
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
-----
41
PsiBlast_CBE
75.94
86%
-128
- C2 -
2ZY0
1
RXRA_HUMAN
A:
[5-236]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
-------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
76
PsiBlast_CBE
75.88
88%
-130
- C2 -
4K6I
1
?
A:
[1-231]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
-------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
6
PsiBlast_PDB
75.64
98%
-141
- C2 -
1H9U
1
RXRB_HUMAN
A:
[1-224]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
P
V
D
R
I
L
E
A
E
L
A
V
-----------------------
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
S
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
D
V
R
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
R
M
D
K
T
E
L
G
C
L
R
A
I
I
L
F
N
P
D
A
K
G
L
S
N
P
S
E
V
E
V
L
R
E
K
V
Y
A
S
L
E
T
Y
C
K
Q
K
Y
P
E
Q
Q
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
-----------
32
PsiBlast_CBE
75.51
86%
-129
- C2 -
3R5M
1
RXRA_HUMAN
A:
[5-236]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
-------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
57
PsiBlast_CBE
75.37
87%
-116
- C2 -
1FM9
1
RXRA_HUMAN
A:
[3-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
K
T
E
T
Y
V
E
A
N
--
M
G
L
N
P
S
S
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
66
PsiBlast_CBE
75.13
88%
-112
- C2 -
1XV9
1
RXRA_HUMAN
A:
[2-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
K
T
E
T
Y
V
E
A
N
--
M
G
L
N
P
S
S
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
22
PsiBlast_CBE
74.95
98%
-138
- C2 -
1H9U
1
D:
[1-224]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
P
V
D
R
I
L
E
A
E
L
A
V
-----------------------
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
S
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
D
V
R
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
R
M
D
K
T
E
L
G
C
L
R
A
I
I
L
F
N
P
D
A
K
G
L
S
N
P
S
E
V
E
V
L
R
E
K
V
Y
A
S
L
E
T
Y
C
K
Q
K
Y
P
E
Q
Q
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
-----------
54
PsiBlast_CBE
74.70
87%
-117
- C2 -
1K74
1
RXRA_HUMAN
A:
[3-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
K
T
E
T
Y
V
E
A
N
--
M
G
L
N
P
S
S
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
27
PsiBlast_CBE
74.56
86%
-138
- C2 -
4N8R
1
?
C:
[44-239]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
-----
55
PsiBlast_CBE
74.32
87%
-118
- C2 -
1G5Y
1
RXRA_HUMAN
C:
[7-232]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
E
R
I
L
E
A
E
L
A
V
E
P
K
T
E
T
Y
V
E
A
N
--
M
G
L
N
P
S
S
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
------
62
PsiBlast_CBE
74.25
87%
-131
- C2 -
1XDK
1
RXRA_MOUSE
A:
[2-234]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
E
D
M
P
V
E
K
I
L
E
A
E
L
A
V
E
P
------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
8
PsiBlast_PDB
74.23
87%
-130
- C2 -
3UVV
1
RXRA_HUMAN
B:
[7-238]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
K
T
----------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
26
PsiBlast_CBE
74.05
86%
-135
- C2 -
4N8R
1
?
D:
[45-241]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
H
---
23
PsiBlast_CBE
73.93
98%
-139
- C2 -
1H9U
1
RXRB_HUMAN
C:
[1-224]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
P
V
D
R
I
L
E
A
E
L
A
V
-----------------------
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
S
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
D
V
R
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
R
M
D
K
T
E
L
G
C
L
R
A
I
I
L
F
N
P
D
A
K
G
L
S
N
P
S
E
V
E
V
L
R
E
K
V
Y
A
S
L
E
T
Y
C
K
Q
K
Y
P
E
Q
Q
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
-----------
61
PsiBlast_CBE
73.77
87%
-131
- C2 -
1XDK
1
RXRA_MOUSE
E:
[2-234]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
E
D
M
P
V
E
K
I
L
E
A
E
L
A
V
E
P
------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
47
PsiBlast_CBE
73.68
87%
-120
- C2 -
1FBY
1
RXRA_HUMAN
A:
[1-235]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
A
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
--------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
24
PsiBlast_CBE
73.61
98%
-139
- C2 -
1H9U
1
RXRB_HUMAN
B:
[1-224]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
P
V
D
R
I
L
E
A
E
L
A
V
-----------------------
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
S
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
D
V
R
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
R
M
D
K
T
E
L
G
C
L
R
A
I
I
L
F
N
P
D
A
K
G
L
S
N
P
S
E
V
E
V
L
R
E
K
V
Y
A
S
L
E
T
Y
C
K
Q
K
Y
P
E
Q
Q
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
-----------
28
PsiBlast_CBE
73.51
86%
-136
- C2 -
4N8R
1
?
B:
[43-240]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
16
PsiBlast_PDB
73.48
86%
-122
- C2 -
1MZN
1
RXRA_HUMAN
A:
[5-236]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
K
T
E
T
Y
V
E
A
N
----------
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
29
PsiBlast_CBE
73.41
86%
-134
- C2 -
4N5G
1
?
D:
[45-240]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
64
PsiBlast_CBE
73.17
88%
-111
- C2 -
1XVP
1
RXRA_HUMAN
A:
[2-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
K
T
E
T
Y
V
E
A
N
--
M
G
L
N
P
S
S
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
44
PsiBlast_CBE
73.03
86%
-125
- C2 -
1MZN
1
RXRA_HUMAN
E:
[5-236]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
K
T
E
T
Y
V
E
A
N
----------
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
89
PsiBlast_CBE
72.92
76%
-138
- C2 -
4OZT
1
?
U:
[1-193]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
V
A
N
I
C
Q
A
T
N
S
Q
L
Y
Q
L
V
E
W
A
K
H
I
P
H
F
S
S
L
P
I
E
D
Q
V
L
L
L
R
A
G
W
N
E
L
L
I
A
A
F
S
H
R
S
V
E
V
R
D
--
G
I
V
L
G
A
G
I
T
---------------
V
H
R
N
S
A
H
Q
A
G
V
G
T
I
F
D
R
V
L
T
E
L
V
A
K
M
R
D
M
N
M
D
R
T
E
L
G
S
L
R
S
I
I
L
F
N
P
E
V
R
G
L
K
S
G
Q
E
V
E
L
L
R
E
K
V
Y
A
A
L
E
E
Y
T
R
V
T
R
P
E
E
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
I
P
I
D
T
F
L
M
D
M
L
G
S
-----
58
PsiBlast_CBE
72.73
87%
-115
- C2 -
1FM6
1
RXRA_HUMAN
U:
[3-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
K
T
E
T
Y
V
E
A
N
--
M
G
L
N
P
S
S
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
46
PsiBlast_CBE
72.53
87%
-123
- C2 -
1FBY
1
RXRA_HUMAN
B:
[6-235]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
--------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
25
PsiBlast_CBE
72.53
87%
-119
- C2 -
3FC6
1
RXRA_HUMAN
C:
[5-237]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
--------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
-------------
D
T
F
L
M
E
M
L
E
A
-----
60
PsiBlast_CBE
72.50
87%
-117
- C2 -
3A9E
1
RXRA_MOUSE
A:
[3-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
N
E
D
M
P
V
E
K
I
L
E
A
E
L
A
V
E
P
K
----------------
S
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
------
12
PsiBlast_PDB
72.10
86%
-137
- C2 -
4N5G
1
RXRA_HUMAN
A:
[45-240]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
13
PsiBlast_PDB
71.72
86%
-132
- C2 -
4N8R
1
RXRA_HUMAN
A:
[45-241]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
H
---
63
PsiBlast_CBE
70.88
88%
-110
- C2 -
1XVP
1
RXRA_HUMAN
C:
[2-236]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
K
T
E
T
Y
V
E
A
N
--
M
G
L
N
P
S
S
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
H
Q
M
T
65
PsiBlast_CBE
70.83
88%
-111
- C2 -
1XV9
1
RXRA_HUMAN
C:
[2-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
K
T
E
T
Y
V
E
A
N
--
M
G
L
N
P
S
S
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----
34
PsiBlast_CBE
70.34
86%
-124
- C2 -
3R2A
1
RXRA_HUMAN
C:
[6-231]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
-------------------------
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
---------
122
HHSearch
70.31
51%
-137
- C2 -
1G2N
1
?
A:
[42-256]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
V
S
S
L
C
Q
I
G
N
K
Q
I
A
A
L
V
V
W
A
R
D
I
P
H
F
S
Q
L
E
M
E
D
Q
I
L
L
I
K
G
S
W
N
E
L
L
L
F
A
I
A
W
R
S
M
E
F
L
T
EE---------TTSPPQLMCLMPG
M
T
L
H
R
N
S
A
L
Q
A
G
V
G
Q
I
F
D
R
V
L
S
E
L
S
L
K
M
R
T
L
R
V
D
Q
A
E
Y
V
A
L
K
A
I
I
L
L
N
P
D
V
K
G
L
K
N
R
Q
E
V
E
V
L
R
E
K
M
F
L
C
L
D
E
Y
C
R
R
S
R
S
S
E
E
G
R
F
A
A
L
L
L
R
L
P
A
L
R
S
I
S
L
K
S
F
E
H
L
F
F
F
H
L
V
A
D
T
S
I
A
G
Y
I
R
D
A
L
R
N
H
A
---
56
PsiBlast_CBE
70.23
87%
-112
- C2 -
1G5Y
1
RXRA_HUMAN
B:
[7-235]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
E
R
I
L
E
A
E
L
A
V
E
P
K
T
E
T
Y
V
E
A
N
--
M
G
L
N
P
S
S
P
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
H
---
36
PsiBlast_CBE
69.99
86%
-117
- C2 -
3R2A
1
RXRA_HUMAN
A:
[4-231]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
K
-------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
---------
85
PsiBlast_CBE
68.49
88%
-118
- C2 -
3H0A
1
A:
[1-228]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
--------------------
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
-------
86
PsiBlast_CBE
65.75
77%
-116
- C2 -
1XIU
1
RXR_BIOGL
B:
[3-226]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
D
M
P
V
E
Q
I
L
E
A
E
L
A
V
D
P
K
I
D
T
Y
I
D
----------
A
Q
K
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
T
E
L
P
L
E
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
G
F
S
H
R
S
I
M
A
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
S
S
A
H
Q
A
G
V
G
T
I
F
D
R
V
L
T
E
L
V
A
K
M
R
D
M
K
M
D
K
T
E
L
G
C
L
R
A
V
V
L
F
N
P
D
A
K
G
L
T
A
V
Q
E
V
E
Q
L
R
E
K
V
Y
A
S
L
E
E
Y
T
K
S
R
Y
P
E
E
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
Q
P
I
D
T
F
L
M
E
M
L
E
N
P
----
87
PsiBlast_CBE
65.04
77%
-119
- C2 -
1XIU
1
RXR_BIOGL
A:
[4-224]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
D
M
P
V
E
Q
I
L
E
A
E
L
A
V
D
P
K
I
D
T
Y
I
D
----------
A
Q
K
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
T
E
L
P
L
E
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
G
F
S
H
R
S
I
M
A
K
D
--
G
I
L
L
A
T
G
L
H
---------------
V
H
R
S
S
A
H
Q
A
G
V
G
T
I
F
D
R
V
L
T
E
L
V
A
K
M
R
D
M
K
M
D
K
T
E
L
G
C
L
R
A
V
V
L
F
N
P
D
A
K
G
L
T
A
V
Q
E
V
E
Q
L
R
E
K
V
Y
A
S
L
E
E
Y
T
K
S
R
Y
P
E
E
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
Q
P
I
D
T
F
L
M
E
M
L
E
------