@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : M_NR3A2_ESR2: (2016-04-07 )
MEIKNSPSSLTSPASYNCSQSILPLEHGPIYIPSSYVESRHEYSAMTFYSPAVMNYSVPSSTGNLEGGPVRQTASPNVLWPTSGHLSPLATHCQSSLLYAEPQKSPWCEARSLEHTLPVNRETLKRKLGGSGCASPVTSPSAKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRIVRRQRSASEQVHCLNKAKRTSGHTPRVKELLLNSLSPEQLVLTLLEAEPPNVLVSRPSMPFTEASMMMSLTKLADKELVHMIGWAKKIPGFVELSLLDQVRLLESCWMEVLMVGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFGMLLATTARFRELKLQHKEYLCVKAMILLNSSMYPLATASQEAESSRKLTHLLNAVTDALVWVISKSGISSQQQSVRLANLLMLLSHVRHISNKGMEHLLSMKCKNVVPVYDLLLEMLNAHTLRGYKSSISGSECCSTEDSKSKEGSQNLQSQ
Atome Classification :
(191 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280-..--.....290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410...-....420......-.430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEIKNSPSSLTSPASYNCSQSILPLEHG
P
I
YI
P
S
S
Y
V
E
S
R
HEYS
A
M
T
F
YSP
A
V
M
N
YSVPSSTGNLEGGPVRQTASP
N
V
L
WPTSGH
L
S
P
L
A
T
H
C
Q
S
S
L
L
Y
AEPQKSPWCEARSLEHTLPV
N
R
E
T
L
K
R
KLGGSGCASPVTSPSAKRD
A
H
F
C
A
V
C
S
D
YASGYHYGVWS
C
E
G
C
K
A
F
F
K
R
SIQGHN
D
Y
ICPATN
Q
C
TIDKNRR
K
S
C
Q
A
C
R
L
R
K
C
Y
E
V
G
M
V
KCG
S
R
R
E
R
C
G
Y
R
I
V
R
R
QRSAS
E
Q
V
H
C
L
N
K
A
KRTSGHT
P
R
V
K
E
L
L
L
NSL
S
P
E
Q
L
V
L
T
L
LEAEPP
N
V
L
V
-SR--PSMP
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
G
W
A
K
KIPG
F
V
E
L
S
L
L
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
V
G
L
M
W
RSIDHPG
K
L
I
FAPD
L
V
LDRDE
G
K
C
V
E
G
I
L
E
I
F
G
M
L
L
A
T
T
A
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
LNSSMYPLAT-A
S
Q
E
A
E
S
S
R
K
L
T
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
SKSGIS
S
Q
Q
Q
S
V
R
L
A
N
L
L
M
L
L
S
H
V
R
H
I
S
N
K
G
M
E
H
L
L
S
M
K
CKNVV
P
V
Y
D
L
L
L
E
M
L
N
A
H
T
L
R
GYKSSISGSECCSTEDSKSKEGSQNLQSQ
62
PsiBlast_CBE
92.64
91%
-154
- C3 -
3OLL
1
ESR2_HUMAN
A:
[2-238]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
-
A
T
--
A
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
212
HHSearch
92.60
92%
-155
- C3 -
3OLL
1
ESR2_HUMAN
A:
[3-238]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
-
A
T
--
A
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
2
PsiBlast_PDB
92.05
97%
-156
- C3 -
2J7Y
7
A:
[8-244]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
N
V
L
V
-
S
-------
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
G
W
A
K
K
I
P
G
F
V
E
L
S
L
L
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
V
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
A
-------
E
S
S
R
K
L
T
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
V
R
L
A
N
L
L
M
L
L
S
H
V
R
H
I
S
N
K
G
M
E
H
L
L
S
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
28
PsiBlast_CBE
92.04
91%
-155
- C3 -
1U3R
1
B:
[3-241]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
-------------
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
R
-----------------------------
34
PsiBlast_CBE
92.00
91%
-153
- C3 -
4J24
1
ESR2_HUMAN
A:
[2-238]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
-------------
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
33
PsiBlast_CBE
91.94
91%
-153
- C3 -
4J24
1
ESR2_HUMAN
B:
[1-238]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
-----------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
1
PsiBlast_PDB
91.94
97%
-156
- C3 -
2J7X
5
A:
[8-244]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
N
V
L
V
-
S
-----
M
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
G
W
A
K
K
I
P
G
F
V
E
L
S
L
L
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
V
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
A
-------
E
S
S
R
K
L
T
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
V
R
L
A
N
L
L
M
L
L
S
H
V
R
H
I
S
N
K
G
M
E
H
L
L
S
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
32
PsiBlast_CBE
91.87
91%
-156
- C3 -
4J24
1
ESR2_HUMAN
C:
[2-238]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
-------------
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
19
PsiBlast_PDB
91.73
91%
-155
- C3 -
1X7B
1
ESR2_HUMAN
A:
[3-240]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
-----------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
56
PsiBlast_CBE
91.55
92%
-154
- C3 -
2NV7
1
ESR2_HUMAN
A:
[1-238]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
-----------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
61
PsiBlast_CBE
91.53
91%
-156
- C3 -
3OLL
1
B:
[2-238]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
-
A
T
---
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
36
PsiBlast_CBE
91.37
91%
-156
- C3 -
3OMQ
1
ESR2_HUMAN
A:
[4-237]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
49
PsiBlast_CBE
91.30
91%
-154
- C3 -
1U3S
1
B:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
-------------
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
43
PsiBlast_CBE
91.29
91%
-157
- C3 -
2YJD
1
B:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
-------------
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
207
HHSearch
91.14
91%
-154
- C3 -
1YYE
1
ESR2_HUMAN
A:
[2-238]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
-----------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
30
PsiBlast_CBE
91.07
91%
-153
- C3 -
4J26
1
ESR2_HUMAN
A:
[1-238]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
-----------
A
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
20
PsiBlast_PDB
91.05
91%
-156
- C3 -
1X7J
1
ESR2_HUMAN
A:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
-----------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
31
PsiBlast_CBE
91.04
91%
-158
- C3 -
4J24
1
D:
[4-237]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
--------------
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
6
PsiBlast_PDB
91.04
91%
-155
- C3 -
1YYE
1
ESR2_HUMAN
A:
[1-238]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
-----------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
44
PsiBlast_CBE
90.93
91%
-157
- C3 -
2YJD
1
ESR2_HUMAN
A:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
-------------
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
37
PsiBlast_CBE
90.93
91%
-158
- C3 -
3OMP
1
B:
[4-235]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
-
A
--------
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
-----------------------------------
54
PsiBlast_CBE
90.87
91%
-156
- C3 -
1U3Q
1
ESR2_HUMAN
A:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
----------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
41
PsiBlast_CBE
90.86
91%
-157
- C3 -
3OLS
1
B:
[4-235]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
-
A
--------
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
-----------------------------------
40
PsiBlast_CBE
90.82
91%
-154
- C3 -
3OMO
1
ESR2_HUMAN
A:
[4-237]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
42
PsiBlast_CBE
90.81
91%
-156
- C3 -
3OLS
1
ESR2_HUMAN
A:
[4-237]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
38
PsiBlast_CBE
90.80
91%
-156
- C3 -
3OMP
1
ESR2_HUMAN
A:
[4-237]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
50
PsiBlast_CBE
90.76
91%
-151
- C3 -
1U3S
1
ESR2_HUMAN
A:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
---------
A
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
39
PsiBlast_CBE
90.76
91%
-159
- C3 -
3OMO
1
B:
[4-235]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
-
A
--------
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
-----------------------------------
52
PsiBlast_CBE
90.74
91%
-157
- C3 -
1U3Q
1
ESR2_HUMAN
C:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
----------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
15
PsiBlast_PDB
90.72
91%
-153
- C3 -
1U3R
1
ESR2_HUMAN
A:
[3-240]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
--------
Q
D
A
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
16
PsiBlast_PDB
90.60
91%
-156
- C3 -
2GIU
1
A:
[1-241]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
------
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
-
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
------
A
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
----
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
18
PsiBlast_PDB
90.58
91%
-154
- C3 -
1X78
1
ESR2_HUMAN
A:
[3-240]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
-----------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
7
PsiBlast_PDB
90.58
90%
-152
- C3 -
1QKM
1
A:
[6-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
------
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
------
A
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
14
PsiBlast_PDB
90.48
91%
-154
- C3 -
1U9E
1
ESR2_HUMAN
A:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
-------------
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
58
PsiBlast_CBE
90.38
92%
-150
- C3 -
1ZAF
1
ESR2_HUMAN
A:
[1-238]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
A
M
-----------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
17
PsiBlast_PDB
90.33
91%
-154
- C3 -
1X76
1
ESR2_HUMAN
A:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
-----------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
208
HHSearch
90.24
91%
-150
- C3 -
1L2J
1
ESR2_HUMAN
A:
[27-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
-------
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
----
L
V
T
-
A
T
Q
D
A
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
R
-----------------------------
3
PsiBlast_PDB
90.24
96%
-153
- C3 -
1QKN
1
A:
[8-243]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
N
V
L
V
-
S
R
--
P
S
M
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
G
W
A
K
K
I
P
G
F
V
E
L
S
L
L
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
V
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
A
S
-
A
N
Q
E
A
E
S
S
R
K
L
T
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
V
R
L
A
N
L
L
M
L
L
S
H
V
R
H
I
S
N
K
G
M
E
H
L
L
S
M
K
--------
D
L
L
L
E
M
L
N
A
---------------------------------
35
PsiBlast_CBE
90.17
91%
-158
- C3 -
3OMQ
1
B:
[4-235]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
-
A
--------
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
-----------------------------------
47
PsiBlast_CBE
90.14
91%
-150
- C3 -
1X78
1
B:
[3-240]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
-----------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
51
PsiBlast_CBE
90.11
91%
-158
- C3 -
1U3Q
1
D:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
----------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
46
PsiBlast_CBE
90.10
91%
-152
- C3 -
1X7B
1
B:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
-----------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
55
PsiBlast_CBE
90.04
92%
-152
- C3 -
2NV7
1
B:
[1-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
-----------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
12
PsiBlast_PDB
90.04
91%
-155
- C3 -
2QTU
1
ESR2_HUMAN
A:
[13-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
------
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
--------
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
------
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
29
PsiBlast_CBE
89.97
91%
-154
- C3 -
4J26
1
B:
[1-238]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
A
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
57
PsiBlast_CBE
89.82
92%
-154
- C3 -
1ZAF
1
B:
[1-238]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
A
M
-----------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
8
PsiBlast_PDB
89.81
89%
-150
- C3 -
1L2J
1
ESR2_HUMAN
A:
[27-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
-------
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
----
L
V
T
-
A
T
Q
D
A
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
R
-----------------------------
22
PsiBlast_CBE
89.76
91%
-158
- C3 -
1YY4
1
B:
[1-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
-----------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
11
PsiBlast_PDB
89.72
91%
-154
- C3 -
2Z4B
1
ESR2_HUMAN
A:
[13-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
------
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
--------
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
----
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
60
PsiBlast_CBE
89.69
91%
-161
- C3 -
2YLY
1
ESR2_HUMAN
A:
[2-237]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
---------
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
-------------
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
48
PsiBlast_CBE
89.66
91%
-153
- C3 -
1X76
1
B:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
-----------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
45
PsiBlast_CBE
89.58
91%
-154
- C3 -
1X7J
1
B:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
-----------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
25
PsiBlast_CBE
89.49
91%
-156
- C3 -
2QTU
1
B:
[12-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
------
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
--------
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
------
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
9
PsiBlast_PDB
89.48
91%
-154
- C3 -
2I0G
1
ESR2_HUMAN
A:
[13-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
------
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
--------
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
----
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
53
PsiBlast_CBE
89.47
91%
-155
- C3 -
1U3Q
1
ESR2_HUMAN
B:
[1-237]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
-----------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
13
PsiBlast_PDB
89.45
91%
-148
- C3 -
1NDE
1
A:
[15-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
--
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
-----
A
T
Q
D
A
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
24
PsiBlast_CBE
89.40
91%
-153
- C3 -
2Z4B
1
B:
[12-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
------
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
--------
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
----
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
5
PsiBlast_PDB
89.23
91%
-152
- C3 -
1YY4
1
ESR2_HUMAN
A:
[1-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
-----------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
27
PsiBlast_CBE
89.14
91%
-154
- C3 -
2I0G
1
B:
[12-250]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
------
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
--------
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
----
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
21
PsiBlast_CBE
88.96
91%
-151
- C3 -
1YYE
1
B:
[1-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
--
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
-----------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
----------------------------------
59
PsiBlast_CBE
88.89
91%
-152
- C3 -
2YLY
1
B:
[1-238]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
---------
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
-------------
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
23
PsiBlast_CBE
88.59
89%
-158
- C3 -
1L2J
1
ESR2_HUMAN
B:
[21-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
E
L
L
L
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
----------------
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
--
L
V
T
-
A
T
Q
D
A
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
-----
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
4
PsiBlast_PDB
86.78
96%
-156
- C3 -
1HJ1
2
A:
[9-226]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
N
V
L
V
-
S
R
--
P
S
M
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
G
W
A
K
K
I
P
G
F
V
E
L
S
L
L
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
V
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
---------------
S
R
K
L
T
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
V
R
L
A
N
L
L
M
L
L
S
H
V
R
H
I
S
N
K
G
M
E
H
L
L
S
M
K
--------------------------------------------------
141
PsiBlast_CBE
84.19
58%
-147
- C3 -
2QSE
1
B:
[13-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
-----------------------------
191
PsiBlast_CBE
83.88
58%
-151
- C3 -
4PPS
1
B:
[5-243]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
152
PsiBlast_CBE
83.84
58%
-152
- C3 -
2QAB
1
ESR1_HUMAN
A:
[13-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
186
PsiBlast_CBE
83.77
58%
-149
- C3 -
4IU7
1
B:
[7-247]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
--
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
-------
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
------------------------------
148
PsiBlast_CBE
83.75
58%
-151
- C3 -
2QGW
1
ESR1_HUMAN
A:
[13-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
203
PsiBlast_CBE
83.74
58%
-147
- C3 -
3L03
2
ESR1_HUMAN
A:
[12-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
---------
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
131
PsiBlast_CBE
83.75
58%
-155
- C3 -
4ZN9
1
?
A:
[9-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
--------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
A
P
T
S
-------------------------
168
PsiBlast_CBE
83.74
58%
-153
- C3 -
1PCG
1
ESR1_HUMAN
A:
[6-244]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
-
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
------------
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
S
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
--------------------------------
167
PsiBlast_CBE
83.73
58%
-146
- C3 -
1PCG
1
B:
[6-244]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
--
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
S
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
--------------------------------
97
PsiBlast_CBE
83.71
59%
-145
- C3 -
1GWQ
1
ESR1_HUMAN
A:
[9-247]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
-----
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
64
PsiBlast_CBE
83.71
58%
-142
- C3 -
2YJA
1
B:
[13-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
------------------------------
143
PsiBlast_CBE
83.50
58%
-148
- C3 -
2QR9
1
B:
[13-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
-----------------------------
198
PsiBlast_CBE
83.47
58%
-158
- C3 -
2QXS
1
ESR1_HUMAN
A:
[13-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
-
R
P
F
S
-
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
S
Y
D
L
L
L
E
M
L
D
A
H
--------------------------------
157
PsiBlast_CBE
83.41
58%
-144
- C3 -
2P15
1
B:
[13-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
-----------------------------
98
PsiBlast_CBE
83.39
59%
-146
- C3 -
1GWR
1
B:
[5-244]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
--
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
183
PsiBlast_CBE
83.36
58%
-150
- C3 -
4IV2
1
B:
[7-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
--
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
-----
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
149
PsiBlast_CBE
83.33
58%
-147
- C3 -
2QGT
1
B:
[13-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
------
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
142
PsiBlast_CBE
83.30
58%
-148
- C3 -
2QSE
1
ESR1_HUMAN
A:
[13-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
----
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
---
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
------------------------------
147
PsiBlast_CBE
83.26
58%
-147
- C3 -
2QGW
1
B:
[13-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
----
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
------------------------------
130
PsiBlast_CBE
83.26
58%
-149
- C3 -
4ZN9
1
?
B:
[9-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
----------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
A
P
T
S
-------------------------
153
PsiBlast_CBE
83.20
58%
-146
- C3 -
2QA6
1
B:
[13-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
-----------------------------
190
PsiBlast_CBE
83.18
58%
-145
- C3 -
1X7E
1
ESR1_HUMAN
A:
[5-245]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
V
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
------------------------------
175
PsiBlast_CBE
83.18
58%
-149
- C3 -
4IW6
1
B:
[7-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
---
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-------
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
138
PsiBlast_CBE
83.18
58%
-146
- C3 -
4DMA
1
ESR1_HUMAN
A:
[7-247]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
A
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
------------------------------
137
PsiBlast_CBE
83.17
58%
-153
- C3 -
4DMA
1
B:
[7-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
A
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
172
PsiBlast_CBE
83.11
58%
-150
- C3 -
4IWC
1
ESR1_HUMAN
A:
[7-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
187
PsiBlast_CBE
83.10
58%
-145
- C3 -
4IU7
1
ESR1_HUMAN
A:
[7-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
154
PsiBlast_CBE
83.07
58%
-146
- C3 -
2QA6
1
ESR1_HUMAN
A:
[13-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
Y
D--
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
------------------------------
179
PsiBlast_CBE
83.05
58%
-149
- C3 -
4IVW
1
B:
[7-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
--
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
------
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
170
PsiBlast_CBE
83.05
58%
-146
- C3 -
4IWF
1
ESR1_HUMAN
A:
[7-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
197
PsiBlast_CBE
83.03
58%
-157
- C3 -
2QXS
1
B:
[13-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
Y--------
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
----------
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
S
Y
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
100
PsiBlast_CBE
83.04
58%
-153
- C3 -
4PXM
1
B:
[26-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
-------
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
------------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
G
L
L
L
E
M
L
D
A
H
R
-------------------------------
196
PsiBlast_CBE
83.03
58%
-153
- C3 -
4PP6
1
ESR1_HUMAN
A:
[5-243]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
84
PsiBlast_CBE
83.01
59%
-143
- C3 -
1QKU
1
ESR1_HUMAN
B:
[9-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
-----------------------------
146
PsiBlast_CBE
82.96
58%
-153
- C3 -
2QH6
1
ESR1_HUMAN
A:
[13-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD--
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
-
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
211
HHSearch
82.92
58%
-153
- C3 -
1XPC
1
A:
[6-245]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
--
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
-
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
----------------------------
86
PsiBlast_CBE
82.90
59%
-142
- C3 -
1G50
1
C:
[6-244]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
--------------------------------
156
PsiBlast_CBE
82.87
58%
-140
- C3 -
2Q6J
1
ESR1_HUMAN
A:
[13-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
--
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
------------------------------
189
PsiBlast_CBE
82.86
58%
-146
- C3 -
1X7E
1
B:
[5-245]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
V
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
------------------------------
199
PsiBlast_CBE
82.84
57%
-147
- C3 -
3OS8
1
ESR1_HUMAN
B:
[14-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
S
Y
D
L
L
L
E
M
L
D
A
---------------------------------
193
PsiBlast_CBE
82.83
58%
-151
- C3 -
4PPP
1
B:
[5-243]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
------
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
151
PsiBlast_CBE
82.78
58%
-144
- C3 -
2QAB
1
B:
[13-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
------------------------------
91
PsiBlast_CBE
82.77
58%
-151
- C3 -
1XPC
1
A:
[3-245]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
----------------------------
88
PsiBlast_CBE
82.75
59%
-140
- C3 -
1G50
1
ESR1_HUMAN
A:
[6-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
-----------------------------
171
PsiBlast_CBE
82.73
58%
-147
- C3 -
4IWC
1
B:
[7-247]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
------------------------------
180
PsiBlast_CBE
82.71
58%
-151
- C3 -
4IVW
1
ESR1_HUMAN
A:
[7-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
101
PsiBlast_CBE
82.69
58%
-154
- C3 -
4PXM
1
ESR1_HUMAN
A:
[26-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
--------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
G
L
L
L
E
M
L
D
A
H
R
L
------------------------------
158
PsiBlast_CBE
82.67
58%
-143
- C3 -
2P15
1
ESR1_HUMAN
A:
[13-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
Y---
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
------------------------------
155
PsiBlast_CBE
82.66
58%
-148
- C3 -
2Q6J
1
B:
[13-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
------------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
145
PsiBlast_CBE
82.64
58%
-154
- C3 -
2QH6
1
B:
[13-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD----
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
--------------------------------
109
PsiBlast_CBE
82.61
58%
-147
- C3 -
3OSA
1
ESR1_HUMAN
C:
[14-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
Y---------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
---
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
S
Y
D
L
L
L
E
M
L
D
A
---------------------------------
96
PsiBlast_CBE
82.61
59%
-144
- C3 -
1GWQ
1
B:
[9-247]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
------
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
150
PsiBlast_CBE
82.60
58%
-150
- C3 -
2QGT
1
ESR1_HUMAN
A:
[13-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
200
PsiBlast_CBE
82.58
57%
-145
- C3 -
3OS8
1
ESR1_HUMAN
A:
[14-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
S
Y
D
L
L
L
E
M
L
D
A
---------------------------------
206
HHSearch
82.52
56%
-145
- C3 -
2OCF
1
A:
[10-251]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
--
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-----------
K
D
H
I
H
R
-
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
93
PsiBlast_CBE
82.48
58%
-146
- C3 -
1XP6
1
A:
[3-245]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
----------------------------
174
PsiBlast_CBE
82.44
58%
-147
- C3 -
4IW8
1
ESR1_HUMAN
A:
[7-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
--
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
99
PsiBlast_CBE
82.40
59%
-145
- C3 -
1GWR
1
ESR1_HUMAN
A:
[5-245]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
Y---
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
------------------------------
201
PsiBlast_CBE
82.39
57%
-148
* C3 *
2QA8
1
ESR1_HUMAN
A:
[13-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
------
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
139
PsiBlast_CBE
82.36
58%
-144
- C3 -
2QXM
1
B:
[13-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
-----------------------------
87
PsiBlast_CBE
82.34
59%
-142
- C3 -
1G50
1
ESR1_HUMAN
B:
[6-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
------------------------------
178
PsiBlast_CBE
82.30
58%
-150
- C3 -
4IVY
1
ESR1_HUMAN
A:
[7-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
---
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
--------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
188
PsiBlast_CBE
82.31
58%
-144
- C3 -
1X7R
1
A:
[5-243]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
-------
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
V
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
--------------------------------
94
PsiBlast_CBE
82.30
58%
-146
- C3 -
1XP1
1
A:
[3-245]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
----------------------------
85
PsiBlast_CBE
82.30
59%
-140
- C3 -
1QKU
1
ESR1_HUMAN
A:
[9-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
-----------------------------
169
PsiBlast_CBE
82.18
58%
-153
- C3 -
4IWF
1
B:
[7-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD----
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
------------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
134
PsiBlast_CBE
82.17
58%
-152
- C3 -
1XQC
1
ESR1_HUMAN
B:
[10-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
---------
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
182
PsiBlast_CBE
82.16
58%
-147
- C3 -
4IV4
1
ESR1_HUMAN
A:
[7-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
----
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
-
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
195
PsiBlast_CBE
82.15
58%
-151
- C3 -
4PP6
1
B:
[5-243]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD----
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-----------
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
176
PsiBlast_CBE
82.14
58%
-147
- C3 -
4IW6
1
ESR1_HUMAN
A:
[7-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
83
PsiBlast_CBE
82.13
59%
-143
- C3 -
1QKU
1
C:
[9-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
-----------------------------
194
PsiBlast_CBE
82.09
58%
-152
- C3 -
4PPP
1
ESR1_HUMAN
A:
[5-243]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
------
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
127
PsiBlast_CBE
82.07
58%
-141
- C3 -
2AYR
1
A:
[6-248]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
S
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
----------------------------
202
PsiBlast_CBE
82.02
58%
-145
- C3 -
3L03
1
B:
[12-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
-----------------------------
108
PsiBlast_CBE
82.02
58%
-150
- C3 -
3OSA
1
D:
[14-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
Y---------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
---
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
------
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
S
Y
D
L
L
L
E
M
L
D
A
H
--------------------------------
177
PsiBlast_CBE
81.99
58%
-145
- C3 -
4IVY
1
B:
[7-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
-----
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
--------
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
192
PsiBlast_CBE
81.97
58%
-145
- C3 -
4PPS
1
ESR1_HUMAN
A:
[5-243]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
-
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
------
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
184
PsiBlast_CBE
81.98
58%
-150
- C3 -
4IV2
1
ESR1_HUMAN
A:
[7-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
--------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
162
PsiBlast_CBE
81.97
58%
-153
- C3 -
5AK2
1
ESR1_HUMAN
A:
[23-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
--------
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-----
V
P
S
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
P
---------------------------
159
PsiBlast_CBE
81.89
58%
-144
- C3 -
3HLV
1
B:
[12-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
------
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
117
PsiBlast_CBE
81.89
58%
-156
- C3 -
2R6Y
1
B:
[6-242]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
-----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
------
P
L
Y
D
L
L
L
E
M
L
D
----------------------------------
129
PsiBlast_CBE
81.87
58%
-146
- C3 -
2YAT
3
A:
[10-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
---------
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
S
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
119
PsiBlast_CBE
81.82
58%
-152
- C3 -
2R6W
1
B:
[6-243]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
Y--------
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
--------
P
L
Y
D
L
L
L
E
M
L
D
A
---------------------------------
110
PsiBlast_CBE
81.82
58%
-144
- C3 -
3OSA
1
ESR1_HUMAN
B:
[14-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
-
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
-
V
V
P
S
Y
D
L
L
L
E
M
L
D
A
---------------------------------
115
PsiBlast_CBE
81.81
58%
-150
- C3 -
3OS8
1
D:
[14-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD--------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
------
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
S
Y
D
L
L
L
E
M
L
D
A
H
--------------------------------
65
PsiBlast_CBE
81.78
58%
-146
- C3 -
2OUZ
1
A:
[9-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
----------------------------
160
PsiBlast_CBE
81.73
58%
-144
- C3 -
3HLV
1
ESR1_HUMAN
A:
[12-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
---
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
116
PsiBlast_CBE
81.71
58%
-145
- C3 -
3OS8
1
ESR1_HUMAN
C:
[14-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD--------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
S
Y
D
L
L
L
E
M
L
D
A
---------------------------------
82
PsiBlast_CBE
81.67
58%
-145
- C3 -
2IOG
1
A:
[1-243]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
----------------------------
128
PsiBlast_CBE
81.62
58%
-144
- C3 -
1QKT
1
A:
[6-248]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
S
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
----------------------------
132
PsiBlast_CBE
81.53
58%
-148
- C3 -
1XQC
1
D:
[10-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
---------
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
126
PsiBlast_CBE
81.50
58%
-148
- C3 -
2POG
1
ESR1_HUMAN
A:
[6-247]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
Y--------
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
----
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
-----------------------------
140
PsiBlast_CBE
81.49
58%
-147
- C3 -
2QXM
1
ESR1_HUMAN
A:
[13-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
Y---
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
-----
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
-----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
------------------------------
90
PsiBlast_CBE
81.43
58%
-147
- C3 -
1YIM
1
A:
[3-245]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
----------------------------
92
PsiBlast_CBE
81.31
58%
-145
- C3 -
1XP9
1
A:
[3-245]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
----------------------------
181
PsiBlast_CBE
81.21
58%
-147
- C3 -
4IV4
1
B:
[7-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
----
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
---------
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
135
PsiBlast_CBE
81.19
58%
-149
- C3 -
1XQC
1
ESR1_HUMAN
A:
[10-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
------
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
114
PsiBlast_CBE
81.18
58%
-148
- C3 -
3OS9
1
ESR1_HUMAN
A:
[14-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
S
T
L
K
S
L
E
E
K
-
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
----
V
V
P
S
Y
D
L
L
L
E
M
L
D
A
---------------------------------
95
PsiBlast_CBE
81.11
58%
-149
- C3 -
1SJ0
1
A:
[3-245]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
--
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
----------------------------
173
PsiBlast_CBE
81.10
58%
-143
- C3 -
4IW8
1
B:
[7-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
133
PsiBlast_CBE
81.04
58%
-148
- C3 -
1XQC
1
ESR1_HUMAN
C:
[10-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
------
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
144
PsiBlast_CBE
80.99
58%
-142
- C3 -
2QR9
1
ESR1_HUMAN
A:
[13-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
Y---
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
------------------------------
76
PsiBlast_CBE
80.93
58%
-144
- C3 -
3ERT
1
A:
[16-258]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
P
---------------------------
63
PsiBlast_CBE
80.90
58%
-146
- C3 -
3DT3
1
ESR1_HUMAN
A:
[13-255]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
-------
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
--
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
----------------------------
185
PsiBlast_CBE
80.82
58%
-152
- C3 -
4IUI
1
B:
[7-247]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
----
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
--------
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
----------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
------------------------------
161
PsiBlast_CBE
80.81
58%
-160
- C3 -
5AK2
1
B:
[23-259]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
-----
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
-------------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-----------
L
L
E
M
L
D
----------------------------------
113
PsiBlast_CBE
80.80
58%
-146
- C3 -
3OS9
1
ESR1_HUMAN
B:
[14-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
---
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-------
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
----
V
V
P
S
Y
D
L
L
L
E
M
L
D
A
---------------------------------
163
PsiBlast_CBE
80.78
58%
-150
- C3 -
2I0J
1
D:
[6-244]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD--------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-------
L
Y
D
L
L
L
E
M
L
D
A
H
--------------------------------
165
PsiBlast_CBE
80.68
58%
-149
- C3 -
2I0J
1
ESR1_HUMAN
B:
[6-244]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD-------
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
------
P
L
Y
D
L
L
L
E
M
L
D
A
H
--------------------------------
89
PsiBlast_CBE
80.62
58%
-148
- C3 -
1YIN
1
A:
[3-245]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
----
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
----------------------------
81
PsiBlast_CBE
80.53
58%
-139
- C3 -
1R5K
2
ESR1_HUMAN
A:
[16-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD----
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
----------------------------------
118
PsiBlast_CBE
80.43
58%
-147
- C3 -
2R6Y
1
ESR1_HUMAN
A:
[6-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
Y
D
P
-------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-----
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
------------------------------
80
PsiBlast_CBE
80.37
58%
-146
- C3 -
1R5K
1
ESR1_HUMAN
B:
[16-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD----
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
-----------------------------------
73
PsiBlast_CBE
80.30
58%
-143
- C3 -
2IOK
1
ESR1_HUMAN
A:
[9-244]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
Y-------
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
-----
P
L
Y
D
L
L
L
E
M
L
-----------------------------------
75
PsiBlast_CBE
80.13
58%
-141
- C3 -
1A52
1
ESR1_HUMAN
A:
[13-248]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
E
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
-----------------------------------
120
PsiBlast_CBE
80.12
58%
-150
- C3 -
2R6W
1
ESR1_HUMAN
A:
[6-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
Y--------
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
-------
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
------------------------------
124
PsiBlast_CBE
80.11
58%
-143
- C3 -
2Q70
1
ESR1_HUMAN
A:
[6-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
Y
D
P
----
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-----
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
------------------------------
79
PsiBlast_CBE
79.87
58%
-145
- C3 -
1R5K
1
C:
[16-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD----
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
-----------------------------------
74
PsiBlast_CBE
79.31
58%
-138
- C3 -
1A52
1
B:
[13-248]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
YD
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
E
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
-----------------------------------
111
PsiBlast_CBE
79.05
58%
-156
- C3 -
3OS9
2
D:
[14-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
------
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
---------
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
-------
V
P
S
Y
D
L
L
L
E
M
L
-----------------------------------
112
PsiBlast_CBE
79.03
58%
-149
- C3 -
3OS9
2
ESR1_HUMAN
C:
[14-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
Y---------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
------
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
-----
V
V
P
S
Y
D
L
L
L
E
M
L
D
A
---------------------------------
72
PsiBlast_CBE
78.98
58%
-143
- C3 -
2IOK
1
B:
[9-244]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
Y
D
P
T
R
----
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
-------
P
L
Y
D
L
L
L
E
M
L
-----------------------------------
122
PsiBlast_CBE
78.26
58%
-147
- C3 -
2QE4
1
ESR1_HUMAN
A:
[6-225]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
-----
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
------------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
---------------------------------------------------
125
PsiBlast_CBE
78.21
58%
-140
- C3 -
2POG
1
B:
[6-225]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
---------------------------------------------------
164
PsiBlast_CBE
78.13
58%
-141
- C3 -
2I0J
1
ESR1_HUMAN
C:
[6-225]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
---------------------------------------------------
123
PsiBlast_CBE
77.57
58%
-141
- C3 -
2Q70
1
B:
[6-225]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
---------------------------------------------------
166
PsiBlast_CBE
77.49
58%
-141
- C3 -
2I0J
1
ESR1_HUMAN
A:
[6-225]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
---------------------------------------------------
121
PsiBlast_CBE
77.17
58%
-147
- C3 -
2QE4
1
B:
[6-225]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-
I
L
Y
-
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
---------------------------------------------------