@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : X_NR1A1_THAB: (2016-04-07 )
MDQNLSGLDCLSEPDEKRWPDGKRKRKNSQCMGKSGMSGDSLVSLPPAGYIPSYLDKDEPCVVCSDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYDGCCIIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEENRVRRRKEEMIKTLQQRPEPSSEEWELIRIVTEAHRSTNAQGSHWKQRRKFLPEDIGQSPMASMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELTCEDQIILLKGCCMEIMSLRAAVRYDPDSETLTLSGEMAVKREQLKNGGLGVVSDAIFDLGRSLAAFNLDDTEVALLQAVLLMSSDRTGLICTDKIEKCQETYLLAFEHYINHRKHNIPHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFEDQEV
Atome Classification :
(16 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDQNLSGLDCLSEPDEKRWPDGKRKRKNSQCMGKSGMSGD
S
L
VSLPPAGYI
P
S
Y
LDKDE
P
C
V
V
CSDKAT
G
Y
H
Y
R
C
I
T
C
E
G
C
K
G
F
F
R
R
T
I
Q
K
NLHPSYSCKYD
G
C
C
I
I
D
K
I
T
R
N
Q
C
Q
L
C
R
F
K
K
C
I
A
V
G
M
A
M
D
L
V
LDD
S
K
R
V
A
K
R
K
L
I
E
E
N
R
V
R
R
R
K
E
E
M
I
K
T
L
Q
QRPEPSSE
E
W
E
L
I
R
I
V
T
E
A
HRSTNAQG
S
H
W
K
Q
R
R
KF
L
P
E
D
IGQSPMASMPDGDKV
D
L
E
A
F
S
E
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
KLPMFSELTCED
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
YDPDS
E
T
L
T
LSG
E
M
A
V
K
R
E
Q
LKNGG
L
G
V
V
S
D
A
I
F
D
L
G
R
S
L
AAFNLD
D
T
E
V
A
L
L
Q
A
V
L
L
MSSDRT
G
L
I
C
T
D
K
I
E
K
C
Q
E
T
Y
L
L
A
F
E
H
Y
I
N
H
R
KHNI
P
H
F
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
HAS
R
F
L
H
M
K
VEC
P
T
ELF
P
P
L
F
L
E
V
FEDQEV
1
PsiBlast_PDB
92.04
95%
-119
- C4 -
3UVV
1
THA_CHICK
A:
[4-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
I
K
S
L
Q
H
R
P
S
P
S
A
E
E
W
E
L
I
H
V
V
T
E
A
H
R
S
T
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
--------
P
D
-
D
K
V
D
L
E
A
F
S
E
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
S
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
S
G
E
M
A
V
K
R
E
Q
L
K
N
G
G
L
G
V
V
S
D
A
I
F
D
L
G
K
S
L
S
A
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
T
G
L
I
C
V
D
K
I
E
K
C
Q
E
T
Y
L
L
A
F
E
H
Y
I
N
Y
R
K
H
N
I
P
H
F
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
D
---
22
PsiBlast_CBE
89.73
83%
-132
- C4 -
1N46
1
THB_HUMAN
B:
[8-258]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
E
P
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
N
A
Q
---
W
K
Q
K
R
K
F
L
P
E
D
I
G
Q
A
---------
K
V
D
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
V
S
D
A
I
F
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
F
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
D
---
2
PsiBlast_PDB
89.11
83%
-125
- C4 -
1XZX
1
THB_HUMAN
X:
[22-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
Q
K
S
I
G
H
K
P
E
P
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
G
------------
V
D
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
V
S
D
A
I
F
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
F
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
----
5
PsiBlast_PDB
88.70
82%
-126
- C4 -
1NQ0
6
THB_HUMAN
A:
[4-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
Q
K
S
I
G
H
K
P
E
P
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
N
T
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
G
Q
----------
K
V
D
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
V
S
D
A
I
F
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
F
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
D
---
11
PsiBlast_PDB
88.67
84%
-127
- C4 -
1Q4X
2
THB_HUMAN
A:
[2-253]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
P
E
P
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
--------------
G
K
V
D
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
V
S
D
A
I
F
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
F
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
D
---
47
Fugue
88.18
86%
-125
- C4 -
1BSX
1
THB_HUMAN
A:
[10-260]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
E
P
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
G
Q
A
P
--------
K
V
D
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
V
S
D
A
I
F
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
F
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
D
---
12
PsiBlast_PDB
88.13
84%
-123
- C4 -
1NAX
1
THB_HUMAN
A:
[3-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
E
P
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
G
Q
A
P
I
V
N
A
P
E
G
G
K
V
D
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
V
S
D
A
I
F
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
F
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
----
7
PsiBlast_PDB
88.00
82%
-122
- C4 -
1NQ1
2
THB_HUMAN
A:
[4-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
Q
K
S
I
G
H
K
P
E
P
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
N
A
Q
G
S
H
W
K
Q
K
Q
K
F
L
P
D
D
I
G
Q
----------
K
V
D
L
E
A
F
S
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F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
V
S
D
A
I
F
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
F
W
P
K
L
L
M
K
V
T
D
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I
G
A
C
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A
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E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
D
---
13
PsiBlast_PDB
87.99
84%
-123
- C4 -
2PIN
2
THB_HUMAN
A:
[2-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
P
E
P
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
G
Q
A
P
------
G
G
K
V
D
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
V
S
D
A
I
F
R
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
F
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
----
14
PsiBlast_PDB
87.98
84%
-124
- C4 -
3D57
1
THB_HUMAN
A:
[16-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
P
E
P
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
G
Q
A
P
------
G
G
K
V
D
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
V
S
D
A
I
F
R
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
F
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
----
3
PsiBlast_PDB
87.82
83%
-123
- C4 -
1Y0X
1
THB_HUMAN
X:
[22-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
Q
K
S
I
G
H
K
P
E
P
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
G
------------
V
D
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
V
S
D
A
I
F
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
F
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
----
23
PsiBlast_CBE
87.77
84%
-120
- C4 -
2PIN
2
THB_HUMAN
B:
[3-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
E
P
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
G
Q
A
P
I
V
N
A
P
E
G
G
K
V
D
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
V
S
D
A
I
F
R
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
F
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
----
21
PsiBlast_CBE
87.58
83%
-126
- C4 -
1BSX
1
THB_HUMAN
B:
[10-260]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
E
P
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
G
Q
A
P
--------
K
V
D
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
V
S
D
A
I
F
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
F
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
D
---
4
PsiBlast_PDB
87.55
83%
-125
- C4 -
1BSX
1
THB_HUMAN
A:
[10-260]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
E
P
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
G
Q
A
P
--------
K
V
D
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
V
S
D
A
I
F
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
F
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
D
---
8
PsiBlast_PDB
87.29
83%
-118
- C4 -
1N46
1
THB_HUMAN
A:
[8-258]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
E
P
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
N
A
Q
---
W
K
Q
K
R
K
F
L
P
E
D
I
G
Q
A
P
I
V
N
A
P
E
G
G
K
V
D
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
V
S
D
A
I
F
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
F
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
D
---
6
PsiBlast_PDB
87.20
82%
-119
- C4 -
1NQ2
6
THB_HUMAN
A:
[5-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
Q
K
S
I
G
H
K
P
E
P
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
G
Q
A
--------
G
K
V
D
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
T
A
V
R
Y
E
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
V
S
D
A
I
F
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
F
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
----