@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0002: (2015-11-27 )
MSDLAKRMLLIKPSPTIAVTDKANRLKDEGKKICILAAGEPDFDTPDHIKKVAIQAIDEGKTKYTAVDGTRELKEAIISKLKRDNNLEYALSQVCVGAGAKQVLFNLFMATVNPGDEAIIPAPYWVSYVDMVSLFGGLPVVIECGQGLKLTPELLKNKVTKKTKWLILNSPNNPAGVVYTYGELEGIAQVLLEYPHVNIITDDIYEHIIYDEKFFTIAQVEPKLYNRVFVVNGVSKAYAMTGWRIGYIAGRSDVVKAISTLQSQSTSNPNSIAQAAAVEALNGDHSFLKERMGIFKSRRDFVIEKLNSAPGLLASIPQGAFYLFVSCKDLLGKSTKSGKVINNDLDFAEYLLEDHLVAVIPGIAFGLKNFIRISYATSQEQLEIGCNSIIKACKMLS
Atome Classification :
(28 SA)
---.........10........20........30........40...--.....50........60---........70........80........-90--.-........100.......110.......120.......130.......140..----.--.--...150..--.....160.......170.......180.......190.......200.......210..-.-......220....----...230.......240.......250........260.......270.......280--.---..---.--..--..290.......300.......310.......320.......330.......340.......350.......360.....--..370.......380.......390.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MS
D
L
A
K
R
M
L
L
IKPSP
T
I
A
VTD
K
A
N
R
L
KDEG
K
K
I
C
I
L
AAGEPDFD--
T
P
D
H
I
K
K
V
A
I
Q
A
IDEGK---
T
K
Y
T
AVD
G
T
R
E
L
K
E
A
I
I
S
K
L
KRDN
N
L
E
Y
-
A
---
L
-
S
Q
V
C
VGA
G
A
K
Q
V
L
F
N
L
F
M
A
TVNPGDE
A
I
IP
A
P
Y
W
V
S
Y
V
D
M
V
S
L
FGG
L
P
V
V
I
EC----G--Q--GLKL
T
P
E
L
--
L
K
N
KVTKK
T
K
W
L
I
L
NSPNNP
A
G
V
V
Y
T
Y
G
E
L
E
G
I
A
Q
V
L
L
EYPH
V
N
I
I
T
D
D
I
Y
E
H
I
IY--DE-
K
-
F
F
T
I
A
QVEPKLY
N
----
R
V
F
V
VNGV
S
K
A
YAMTG
W
R
I
G
Y
IA
G
-
R
S
D
V
V
K
A
I
S
T
L
Q
SQSTSN
P
N
S
I
A
Q
A
A
A
V
E
AL---N---G
D
---
H
--
S
F
--
L
K
E
R
M
G
I
F
K
S
R
R
D
F
V
I
E
K
LNSAPG
L
L
A
SIPQG
A
F
Y
L
F
V
S
C
K
D
L
LGKSTKSG
K
V
INND
L
D
F
A
E
Y
L
L
E
D
H
L
V
A
V
I
P
G
I
A
F
G
L
--
K
N
F
I
R
I
SYAT
S
Q
E
Q
L
E
I
G
C
N
S
I
I
K
A
C
KMLS
52
HHSearch
95.52
42%
-109
- C1 -
1J32
2
?
A:
[2-387]
-----
K
L
A
A
R
V
E
S
V
S
P
S
M
T
L
I
I
D
A
K
A
K
A
M
K
A
E
G
I
D
V
C
S
F
S
A
G
E
P
D
F
N
--
T
P
K
H
I
V
E
A
A
K
A
A
L
E
Q
G
K
---
T
R
Y
G
P
A
A
G
E
P
R
L
R
E
A
I
A
Q
K
L
Q
R
D
N
G
L
C
Y
-
G
---
A
-
D
N
I
L
V
T
N
G
G
K
Q
S
I
F
N
L
M
L
A
M
I
E
P
G
D
E
V
I
I
P
A
P
F
W
V
S
Y
P
E
M
V
K
L
A
E
G
T
P
V
I
L
P
T
----
T
VE
T
--
Q
F
K
V
S
P
E
Q
--
I
R
Q
A
I
T
P
K
T
K
L
L
V
F
N
T
P
S
N
P
T
G
M
V
Y
T
P
D
E
V
R
A
I
A
Q
V
A
V
E
A
-
G
L
W
V
L
S
D
E
I
Y
E
K
I
L
Y
--
D
D
-
A
Q
H
L
S
I
G
A
A
S
P
E
A
Y
E
----
R
S
V
V
C
S
G
F
A
K
T
Y
A
M
T
G
W
R
V
G
F
L
A
G
-
P
V
P
L
V
K
A
A
T
K
I
Q
G
H
S
T
S
N
V
C
T
F
A
Q
Y
G
A
I
A
A
Y
---
E
---
N
S
---
Q
--
D
C
--
V
Q
E
M
L
A
A
F
A
E
R
R
R
Y
M
L
D
A
L
N
A
M
P
G
L
E
C
P
K
P
D
G
A
F
Y
M
F
P
S
I
A
K
T
----------
G
R
S
S
L
D
F
C
S
E
L
L
D
Q
H
Q
V
A
T
V
P
G
A
A
F
G
A
--
D
D
C
I
R
L
S
Y
A
T
D
L
D
T
I
K
R
G
M
E
R
L
E
K
F
L
H
G
I
L
21
PsiBlast_CBE
94.37
41%
-110
- C1 -
1J32
2
?
B:
[3-382]
------
L
A
A
R
V
E
S
V
S
P
S
M
T
L
I
I
D
A
K
A
K
A
M
K
A
E
G
I
D
V
C
S
F
S
A
G
E
P
D
F
N
--
T
P
K
H
I
V
E
A
A
K
A
A
L
E
Q
G
K
---
T
R
Y
G
P
A
A
G
E
P
R
L
R
E
A
I
A
Q
K
L
Q
R
D
N
G
L
C
Y
-
G
---
A
-
D
N
I
L
V
T
N
G
G
K
Q
S
I
F
N
L
M
L
A
M
I
E
P
G
D
E
V
I
I
P
A
P
F
W
V
S
Y
P
E
M
V
K
L
A
E
G
T
P
V
I
L
P
T
----
T
VE
T
--
Q
F
K
V
S
P
E
Q
--
I
R
Q
A
I
T
P
K
T
K
L
L
V
F
N
T
P
S
N
P
T
G
M
V
Y
T
P
D
E
V
R
A
I
A
Q
V
A
V
E
A
-
G
L
W
V
L
S
D
E
I
Y
E
K
I
L
Y
--
D
D
A
Q
-
H
L
S
I
G
A
A
S
P
E
A
Y
E
----
R
S
V
V
C
S
G
F
A
K
T
Y
A
M
T
G
W
R
V
G
F
L
A
G
-
P
V
P
L
V
K
A
A
T
K
I
Q
G
H
S
T
S
N
V
C
T
F
A
Q
Y
G
A
I
A
A
Y
---
E
---
N
S
---
Q
--
D
C
--
V
Q
E
M
L
A
A
F
A
E
R
R
R
Y
M
L
D
A
L
N
A
M
P
G
L
E
C
P
K
P
D
G
A
F
Y
M
F
P
S
I
-------
A
K
T
G
R
---
S
S
L
D
F
C
S
E
L
L
D
Q
H
Q
V
A
T
V
P
G
A
A
F
G
A
--
D
D
C
I
R
L
S
Y
A
T
D
L
D
T
I
K
R
G
M
E
R
L
E
K
F
L
H
G
I
L
1
PsiBlast_PDB
93.38
41%
-108
- C1 -
1J32
2
?
A:
[3-382]
------
L
A
A
R
V
E
S
V
S
P
S
M
T
L
I
I
D
A
K
A
K
A
M
K
A
E
G
I
D
V
C
S
F
S
A
G
E
P
D
F
N
--
T
P
K
H
I
V
E
A
A
K
A
A
L
E
Q
G
K
---
T
R
Y
G
P
A
A
G
E
P
R
L
R
E
A
I
A
Q
K
L
Q
R
D
N
G
L
C
Y
-
G
---
A
-
D
N
I
L
V
T
N
G
G
K
Q
S
I
F
N
L
M
L
A
M
I
E
P
G
D
E
V
I
I
P
A
P
F
W
V
S
Y
P
E
M
V
K
L
A
E
G
T
P
V
I
L
P
T
----
T
VE
T
--
Q
F
K
V
S
P
E
Q
--
I
R
Q
A
I
T
P
K
T
K
L
L
V
F
N
T
P
S
N
P
T
G
M
V
Y
T
P
D
E
V
R
A
I
A
Q
V
A
V
E
A
-
G
L
W
V
L
S
D
E
I
Y
E
K
I
L
Y
--
D
D
A
Q
-
H
L
S
I
G
A
A
S
P
E
A
Y
E
----
R
S
V
V
C
S
G
F
A
K
T
Y
A
M
T
G
W
R
V
G
F
L
A
G
-
P
V
P
L
V
K
A
A
T
K
I
Q
G
H
S
T
S
N
V
C
T
F
A
Q
Y
G
A
I
A
A
Y
---
E
---
N
S
---
Q
--
D
C
--
V
Q
E
M
L
A
A
F
A
E
R
R
R
Y
M
L
D
A
L
N
A
M
P
G
L
E
C
P
K
P
D
G
A
F
Y
M
F
P
S
I
-------
A
K
T
G
R
---
S
S
L
D
F
C
S
E
L
L
D
Q
H
Q
V
A
T
V
P
G
A
A
F
G
A
--
D
D
C
I
R
L
S
Y
A
T
D
L
D
T
I
K
R
G
M
E
R
L
E
K
F
L
H
G
I
L
53
HHSearch
93.23
41%
-107
* C1 *
1B5P
3
AAT_THET8
A:
[1-382]
---
M
R
G
L
S
R
R
V
Q
A
M
K
P
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
--
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
---
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
-
T
---
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
----
L
PE
E
--
G
F
V
P
D
P
E
R
--
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
-
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
--
E
G
-
E
-
H
F
S
P
G
R
---
V
A
P
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
-
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
---
T
---
N
Q
E
A
S
R
--
A
F
--
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
S
P
I
----------
A
P
D
E
V
R
A
A
E
R
L
L
-
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
----
79
Fugue
91.36
42%
-114
- C1 -
1BJW
1
AAT_THET8
A:
[1-382]
M
R
G
L
S
R
R
V
Q
A
M
K
---
P
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
--FD
T
P
E
H
V
K
E
A
A
R
R
A
L
A
---
Q
GK
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
----SVT
P
-
E
E
T
I
V
T
V
G
G
K
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
-
A
G
G
V
-
V
V
E
V
E
T
L
P
E
--
E
--
G
F
V
P
D
P
E
R
--
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
-
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
---
E
-
H
F
S
P
G
R
-------VAPE
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
-
K
E
V
I
K
A
M
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
Q
E
---
A
S
---
R
--
A
F
--
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
-----
S
-----
P
I
A
P
D
E
V
R
A
A
E
R
L
L
E
-
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
----
12
PsiBlast_PDB
90.05
37%
-116
- C1 -
1GDE
4
?
A:
[3-384]
------
L
S
D
R
L
E
L
V
S
A
S
E
I
R
K
L
F
D
I
A
A
G
M
K
D
----
V
I
S
L
G
I
G
E
P
D
F
D
--
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
L
---
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P
---
K
-
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
K
P
V
E
V
P
T
----
Y
--
E
ED
E
F
R
L
N
V
D
E
--
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
-
V
I
S
D
E
V
Y
E
H
F
I
Y
--
D
D
A
R
-
H
Y
S
I
A
S
L
D
-
G
M
F
E
----
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
-
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
---
K
---
D
E
---
R
--
S
W
K
A
V
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
-
T
G
L
T
S
K
K
---------
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
AG
E
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
L
K
E
R
K
2
PsiBlast_PDB
89.93
41%
-100
- C1 -
1BKG
4
AAT_THET8
A:
[1-371]
---
M
R
G
L
S
R
R
V
Q
A
M
K
P
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
--
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
---
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
-
T
---
P
-
E
E
T
I
V
T
V
G
G
K
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P--
E
--
E
--
G
F
V
P
D
P
E
R
--
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
-
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
--
E
G
-
E
-
H
F
S
P
G
R
V
A
P
E
-------
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
-
P
K
E
V
I
K
A
M
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
---
T
N
Q
E
A
S
---
R
--
A
F
--
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
-
T
A
L
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
----------
T
S
P
I
A
P
D
E
V
R
A
A
E
R
L
L
E
A
G
-
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
----
13
PsiBlast_PDB
89.67
37%
-117
- C1 -
1GD9
2
?
A:
[3-384]
------
L
S
D
R
L
E
L
V
S
A
S
E
I
R
K
L
F
D
I
A
A
G
M
K
D
----
V
I
S
L
G
I
G
E
P
D
F
D
--
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
L
---
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P
---
K
-
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
K
P
V
E
V
P
T
----
Y
--
E
ED
E
F
R
L
N
V
D
E
--
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
-
V
I
S
D
E
V
Y
E
H
F
I
Y
--
D
D
A
R
-
H
Y
S
I
A
S
L
D
-
G
M
F
E
----
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
-
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
---
K
---
D
E
---
R
--
S
W
K
A
V
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
-
T
G
L
T
S
K
K
---------
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
AG
E
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
L
K
E
R
K
14
PsiBlast_PDB
89.60
37%
-118
- C1 -
1DJU
2
?
A:
[2-383]
------
L
S
D
R
L
E
L
V
S
A
-------------
K
D
----
V
I
S
L
G
I
G
E
P
D
F
D
--
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
L
---
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P
---
K
-
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
K
P
V
E
V
P
T
----
Y
--
E
ED
E
F
R
L
N
V
D
E
--
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
-
V
I
S
D
E
V
Y
E
H
F
I
Y
--
D
D
A
R
-
H
Y
S
I
A
S
L
D
-
G
M
F
E
----
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
-
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
---
K
---
D
E
---
R
--
S
W
K
A
V
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
-
T
G
L
T
S
K
K
---------
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
AG
E
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
E
R
M
E
R
V
L
K
E
R
K
23
PsiBlast_CBE
89.47
41%
-101
- C1 -
1BKG
3
AAT_THET8
C:
[1-371]
---
M
R
G
L
S
R
R
V
Q
A
M
K
P
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
--
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
---
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
-
T
---
P
-
E
E
T
I
V
T
V
G
G
K
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
LP--
E
--
E
--
G
F
V
P
D
P
E
R
--
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
-
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
--
E
G
-
E
-
H
F
S
P
G
R
V
A
P
E
-------
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
-
P
K
E
V
I
K
A
M
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
---
T
NQE
A
S
---
R
--
A
F
--
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
-
T
A
L
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
----------
T
S
P
I
A
P
D
E
V
R
A
A
E
R
L
L
E
A
G
-
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
----
24
PsiBlast_CBE
89.15
41%
-100
- C1 -
1BKG
3
AAT_THET8
B:
[1-371]
---
M
R
G
L
S
R
R
V
Q
A
M
K
P
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
--
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
---
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
-
T
---
P
-
E
E
T
I
V
T
V
G
G
K
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
LP--
E
--
E
--
G
F
V
P
D
P
E
R
--
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
-
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
--
E
G
-
E
-
H
F
S
P
G
R
V
A
P
E
-------
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
-
P
K
E
V
I
K
A
M
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
---
T
NQE
A
S
---
R
--
A
F
--
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
-
T
A
L
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
----------
T
S
P
I
A
P
D
E
V
R
A
A
E
R
L
L
E
A
G
-
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
----
46
PsiBlast_CBE
89.05
37%
-118
- C1 -
1DJU
2
?
B:
[2-383]
------
L
S
D
R
L
E
L
V
S
---------------
D
----
V
I
S
L
G
I
G
E
P
D
F
D
--
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
L
---
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P
---
K
-
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
K
P
V
E
V
P
T
----
Y
--
E
ED
E
F
R
L
N
V
D
E
--
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
-
V
I
S
D
E
V
Y
E
H
F
I
Y
--
D
D
A
R
-
H
Y
S
I
A
S
L
D
-
G
M
F
E
----
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
-
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
---
K
---
D
E
---
R
--
S
W
K
A
V
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
-
T
G
L
T
S
K
K
---------
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
AG
E
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
E
R
M
E
R
V
L
K
E
R
K
55
HHSearch
88.85
38%
-113
- C1 -
1GD9
2
?
A:
[2-386]
-----
A
L
S
D
R
L
E
L
V
S
A
S
E
I
R
K
L
F
D
I
----
A
A
G
M
K
D
V
I
S
L
G
I
G
E
P
D
F
D
--
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
L
---
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
-
D
---
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
K
P
V
E
V
P
T
----
Y
EE
D
--
E
F
R
L
N
V
D
E
--
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
-
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
--
D
D
-
A
R
H
Y
S
I
A
S
L
-
D
G
M
F
E
----
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
-
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
---
K
---
D
E
---
R
S
W
K
A
--
V
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
T
----------
G
L
T
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
AG
E
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
L
K
E
R
K
22
PsiBlast_CBE
88.79
41%
-100
- C1 -
1BKG
3
AAT_THET8
D:
[1-371]
---
M
R
G
L
S
R
R
V
Q
A
M
K
P
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
--
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
---
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
-
T
---
P
-
E
E
T
I
V
T
V
G
G
K
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
LP--
E
--
E
--
G
F
V
P
D
P
E
R
--
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
-
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
--
E
G
-
E
-
H
F
S
P
G
R
V
A
P
E
-------
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
-
P
K
E
V
I
K
A
M
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
---
T
NQE
A
S
---
R
--
A
F
--
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
-
T
A
L
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
----------
T
S
P
I
A
P
D
E
V
R
A
A
E
R
L
L
E
A
G
-
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
----
9
PsiBlast_PDB
87.79
40%
-103
- C1 -
5BJ4
3
AAT_THET8
A:
[1-371]
---
M
R
G
L
S
R
R
V
Q
A
M
K
P
----------------
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
--
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
---
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
-
T
---
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P--
E
--
E
--
G
F
V
P
D
P
E
R
--
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
-
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
--
E
G
-
E
-
H
F
S
P
G
R
V
A
P
E
-------
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
-
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
---
T
N
Q
E
A
S
---
R
--
A
F
--
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
-
T
A
L
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
----------
T
S
P
I
A
P
D
E
V
R
A
A
E
R
L
L
E
A
G
-
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
----
6
PsiBlast_PDB
87.58
41%
-99
- C1 -
1B5P
3
AAT_THET8
A:
[1-371]
---
M
R
G
L
S
R
R
V
Q
A
M
K
P
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
--
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
---
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
-
T
---
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P--
E
--
E
--
G
F
V
P
D
P
E
R
--
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
-
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
--
E
G
-
E
-
H
F
S
P
G
R
V
A
P
E
-------
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
-
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
---
T
N
Q
E
A
S
---
R
--
A
F
--
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
-
T
A
L
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
----------
T
S
P
I
A
P
D
E
V
R
A
A
E
R
L
L
E
A
G
-
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
----
3
PsiBlast_PDB
87.11
41%
-101
- C1 -
1B5O
3
AAT_THET8
A:
[1-371]
---
M
R
G
L
S
R
R
V
Q
A
M
K
P
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
--
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
---
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
-
T
---
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P--
E
--
E
--
G
F
V
P
D
P
E
R
--
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
-
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
--
E
G
-
E
-
H
F
S
P
G
R
V
A
P
E
-------
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
-
P
K
E
V
I
K
A
M
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
---
T
N
Q
E
A
S
---
R
--
A
F
--
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
-
T
A
L
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
----------
T
S
P
I
A
P
D
E
V
R
A
A
E
R
L
L
E
A
G
-
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
----
28
PsiBlast_CBE
87.06
41%
-101
- C1 -
1BJW
1
AAT_THET8
B:
[1-371]
---
M
R
G
L
S
R
R
V
Q
A
M
K
P
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
--
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
---
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
-
T
---
P
-
E
E
T
I
V
T
V
G
G
K
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
LP--
E
--
E
--
G
F
V
P
D
P
E
R
--
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
-
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
--
E
G
-
E
-
H
F
S
P
G
R
V
A
P
E
-------
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
-
P
K
E
V
I
K
A
M
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
---
T
NQE
A
S
---
R
--
A
F
--
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
-
T
A
L
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
----------
T
S
P
I
A
P
D
E
V
R
A
A
E
R
L
L
E
A
G
-
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
----
5
PsiBlast_PDB
86.84
41%
-98
- C1 -
1GCK
4
AAT_THET8
A:
[1-371]
---
M
R
G
L
S
R
R
V
Q
A
M
K
P
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
--
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
---
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
-
T
---
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P--
E
--
E
--
G
F
V
P
D
P
E
R
--
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
-
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
--
E
G
-
E
-
H
F
S
P
G
R
V
A
P
E
-------
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
-
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
---
T
N
Q
E
A
S
---
R
--
A
F
--
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
-
T
A
L
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
----------
T
S
P
I
A
P
D
E
V
R
A
A
E
R
L
L
E
A
G
-
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
----
26
PsiBlast_CBE
86.68
41%
-98
- C1 -
1GCK
4
AAT_THET8
B:
[1-371]
---
M
R
G
L
S
R
R
V
Q
A
M
K
P
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
--
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
---
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
-
T
---
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
LP--
E
--
E
--
G
F
V
P
D
P
E
R
--
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
-
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
--
E
G
-
E
-
H
F
S
P
G
R
V
A
P
E
-------
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
-
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
---
T
NQE
A
S
---
R
--
A
F
--
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
-
T
A
L
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
----------
T
S
P
I
A
P
D
E
V
R
A
A
E
R
L
L
E
A
G
-
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
----
45
PsiBlast_CBE
86.56
37%
-116
- C1 -
1GD9
2
?
B:
[3-384]
------
L
S
D
R
L
E
L
V
S
A
S
E
I
R
K
L
F
D
I
A
A
G
M
K
D
----
V
I
S
L
G
I
G
E
P
D
F
D
--
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
L
---
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P
---
K
-
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
K
P
V
E
V
P
T
----
Y
--
E
ED
E
F
R
L
N
V
D
E
--
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
-
V
I
S
D
E
V
Y
E
H
F
I
Y
--
D
D
A
R
-
H
Y
S
I
A
S
L
D
-
G
M
F
E
----
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
-
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
---
K
---
D
E
---
R
--
S
W
KA
V
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
-
T
G
L
T
S
K
K
---------
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
AG
E
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
L
K
E
R
K
54
HHSearch
86.47
38%
-106
- C1 -
1O4S
8
AAT_THEMA
A:
[14-388]
------
V
S
R
R
I
S
E
I
P
I
S
K
T
M
E
L
D
A
K
A
K
A
L
I
K
K
G
E
D
V
I
N
L
T
A
G
E
P
D
F
P
--
T
P
E
P
V
V
E
E
A
V
R
F
L
Q
K
G
E
---
V
K
Y
T
D
P
R
G
I
Y
E
L
R
E
G
I
A
K
R
I
G
E
R
Y
K
K
D
I
-
S
---
P
-
D
Q
V
V
V
T
N
G
A
K
Q
A
L
F
N
A
F
M
A
L
L
D
P
G
D
E
V
I
V
F
S
P
V
W
V
S
Y
I
P
Q
I
I
L
A
G
G
T
V
N
V
V
E
T
----
F
MS
K
--
N
F
Q
P
S
L
E
E
--
V
E
G
L
L
V
G
K
T
K
A
V
L
I
N
S
P
N
N
P
T
G
V
V
Y
R
R
E
F
L
E
G
L
V
R
L
A
K
K
R
-
N
F
Y
I
I
S
D
E
V
Y
D
S
L
V
Y
--
T
D
-
E
-
F
T
S
I
L
D
-
V
S
E
G
F
D
----
R
I
V
Y
I
N
G
F
S
K
S
H
S
M
T
G
W
R
V
G
Y
L
I
S
-
S
E
K
V
A
T
A
V
S
K
I
Q
S
H
T
T
S
C
I
N
T
V
A
Q
Y
A
A
L
K
A
L
---
E
---
V
D
---
N
-------
S
Y
M
V
Q
T
F
K
E
R
K
N
F
V
V
E
R
L
K
K
M
-
G
V
K
F
V
E
P
E
G
A
F
Y
L
F
F
K
V
R
G
-------------
D
D
V
K
F
C
E
R
L
L
E
E
K
K
V
A
L
V
P
G
S
A
F
L
K
--
P
G
F
V
R
L
S
F
A
T
S
I
E
R
L
T
E
A
L
D
R
I
E
D
F
L
N
S
--
44
PsiBlast_CBE
86.37
37%
-114
- C1 -
1GDE
4
?
B:
[3-384]
------
L
S
D
R
L
E
L
V
S
A
S
E
I
R
K
L
F
D
I
A
A
G
M
K
D
----
V
I
S
L
G
I
G
E
P
D
F
D
--
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
L
---
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P
---
K
-
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
K
P
V
E
V
P
T
----
Y
--
E
ED
E
F
R
L
N
V
D
E
--
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
-
V
I
S
D
E
V
Y
E
H
F
I
Y
--
D
D
A
R
-
H
Y
S
I
A
S
L
D
-
G
M
F
E
----
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
-
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
---
K
---
D
E
---
R
--
S
W
KA
V
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
-
T
G
L
T
S
K
K
---------
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
AG
E
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
L
K
E
R
K
29
PsiBlast_CBE
85.68
40%
-103
- C1 -
5BJ4
3
AAT_THET8
B:
[1-371]
---
M
R
G
L
S
R
R
V
Q
A
M
K
P
----------------
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
--
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
---
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
-
T
---
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
LP--
E
--
E
--
G
F
V
P
D
P
E
R
--
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
-
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
--
E
G
-
E
-
H
F
S
P
G
R
V
A
P
E
-------
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
-
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
---
T
NQE
A
S
---
R
--
A
F
--
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
-
T
A
L
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
----------
T
S
P
I
A
P
D
E
V
R
A
A
E
R
L
L
E
A
G
-
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
----
43
PsiBlast_CBE
85.67
38%
-110
- C1 -
1O4S
4
AAT_THEMA
B:
[14-382]
------
V
S
R
R
I
S
E
I
P
I
S
K
T
M
E
L
D
A
K
A
K
A
L
I
K
K
G
E
D
V
I
N
L
T
A
G
E
P
D
F
P
--
T
P
E
P
V
V
E
E
A
V
R
F
L
Q
K
G
E
---
V
K
Y
T
D
P
R
G
I
Y
E
L
R
E
G
I
A
K
R
I
G
E
R
Y
K
K
D
I
-
S
---
P
-
D
Q
V
V
V
T
N
G
A
K
Q
A
L
F
N
A
F
M
A
L
L
D
P
G
D
E
V
I
V
F
S
P
V
W
V
S
Y
I
P
Q
I
I
L
A
G
G
T
V
N
V
V
E
T
----
F
--
M
--
S
K
N
F
Q
P
S
L
E
E
V
E
G
L
L
V
G
K
T
K
A
V
L
I
N
S
P
N
N
P
T
G
V
V
Y
R
R
E
F
L
E
G
L
V
R
-
L
A
K
K
R
N
F
Y
I
I
S
D
E
V
Y
D
S
L
V
Y
--
T
D
-
E
-
F
T
S
I
L
D
V
S
E
G
-
F
D
----
R
I
V
Y
I
N
G
F
S
K
S
H
S
M
T
G
W
R
V
G
Y
L
I
S
-
S
E
K
V
A
T
A
V
S
K
I
Q
S
H
T
T
S
C
I
N
T
V
A
Q
Y
A
A
L
K
A
L
---
E
---
V
D
---
N
--
S
Y
--
M
---
V
Q
T
F
K
E
R
K
N
F
V
V
E
R
L
K
K
M
-
G
V
K
F
V
E
P
E
G
A
F
Y
L
F
F
-------------
K
V
R
G
D
D
V
K
F
C
E
R
L
L
E
E
K
K
V
A
L
V
P
G
S
A
F
L
K
--
P
G
F
V
R
L
S
F
A
T
S
I
E
R
L
T
E
A
L
D
R
I
E
D
F
L
N
S
--
27
PsiBlast_CBE
85.65
41%
-99
- C1 -
1B5P
3
AAT_THET8
B:
[1-371]
---
M
R
G
L
S
R
R
V
Q
A
M
K
P
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
--
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
---
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
-
T
---
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
LP--
E
--
E
--
G
F
V
P
D
P
E
R
--
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
-
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
--
E
G
-
E
-
H
F
S
P
G
R
V
A
P
E
-------
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
-
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
---
T
NQE
A
S
---
R
--
A
F
--
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
-
T
A
L
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
----------
T
S
P
I
A
P
D
E
V
R
A
A
E
R
L
L
E
A
G
-
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
----
25
PsiBlast_CBE
85.32
41%
-100
- C1 -
1B5O
3
AAT_THET8
B:
[1-371]
---
M
R
G
L
S
R
R
V
Q
A
M
K
P
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
--
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
---
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
-
T
---
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
LP--
E
--
E
--
G
F
V
P
D
P
E
R
--
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
-
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
--
E
G
-
E
-
H
F
S
P
G
R
V
A
P
E
-------
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
-
P
K
E
V
I
K
A
M
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
---
T
NQE
A
S
---
R
--
A
F
--
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
-
T
A
L
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
----------
T
S
P
I
A
P
D
E
V
R
A
A
E
R
L
L
E
A
G
-
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
----
11
PsiBlast_PDB
84.79
38%
-107
- C1 -
1O4S
8
AAT_THEMA
A:
[14-382]
------
V
S
R
R
I
S
E
I
P
I
S
K
T
M
E
L
D
A
K
A
K
A
L
I
K
K
G
E
D
V
I
N
L
T
A
G
E
P
D
F
P
--
T
P
E
P
V
V
E
E
A
V
R
F
L
Q
K
G
E
---
V
K
Y
T
D
P
R
G
I
Y
E
L
R
E
G
I
A
K
R
I
G
E
R
Y
K
K
D
I
-
S
---
P
-
D
Q
V
V
V
T
N
G
A
K
Q
A
L
F
N
A
F
M
A
L
L
D
P
G
D
E
V
I
V
F
S
P
V
W
V
S
Y
I
P
Q
I
I
L
A
G
G
T
V
N
V
V
E
T
----
F
--
M
--
S
K
N
F
Q
P
S
L
E
E
V
E
G
L
L
V
G
K
T
K
A
V
L
I
N
S
P
N
N
P
T
G
V
V
Y
R
R
E
F
L
E
G
L
V
R
-
L
A
K
K
R
N
F
Y
I
I
S
D
E
V
Y
D
S
L
V
Y
--
T
D
-
E
-
F
T
S
I
L
D
V
S
E
G
-
F
D
----
R
I
V
Y
I
N
G
F
S
K
S
H
S
M
T
G
W
R
V
G
Y
L
I
S
-
S
E
K
V
A
T
A
V
S
K
I
Q
S
H
T
T
S
C
I
N
T
V
A
Q
Y
A
A
L
K
A
L
---
E
---
V
D
---
N
--
S
Y
--
M
---
V
Q
T
F
K
E
R
K
N
F
V
V
E
R
L
K
K
M
-
G
V
K
F
V
E
P
E
G
A
F
Y
L
F
F
-------------
K
V
R
G
D
D
V
K
F
C
E
R
L
L
E
E
K
K
V
A
L
V
P
G
S
A
F
L
K
--
P
G
F
V
R
L
S
F
A
T
S
I
E
R
L
T
E
A
L
D
R
I
E
D
F
L
N
S
--