@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0006: (2015-11-27 )
MADNLYLYKGSVKITEMTLNLNEAKIIVYEDSGGNKYTLDASGISTLTNIDDIKLSDLLEGKVKFIYQKKDSNAIQIKGLGNIISTLLATQKAVDGESILAEEVSKKPVVDTILKATDLVNLNKNIVETELEDKFVKKDASNLTDAVNQKAFAEKILPAKDGQKSILVEKLGGLLGEPGAVYGDSNPKITAKDFLAEKASLVKTDGSNIVTQTDKGKALVEAILNAKEPISNKEVKIVETELAKTFVKTADLGTPAVAGKVLDAKDGQKSILVEKLGRFLDTTSTEYSNQTAKVFSGEKGTKPTAEEVVTKLLANNKKDLTDEVAQNPGLRAAVTSNSGLRGTVIDNLKGDTDFKTDITIQVDAKDPAFQGFVREIISQPSFEIPTSDDAPLSWDWI
Atome Classification :
(20 SA)
--------------------------------------------------------------........----.10........20.....-----------------....30-.........40......----..50.-.---------------......60....--------------...--------------.70....--------....80........90.........100.--..---.-...110......-----.120.......130.---......140.......-----150-...--.....160.......170---.........------------180.......190.......200.......210-----....--....220----.......--..230.......240--.........250--------........---------.--------------260...-..--.---.--------270..-.---....280-.....-....--290.---.....-------.300---------........--.310...--.--...320....-----------------------------------...330-.........340---------.......-------------------.----350-----------........360...---....370.---......---------------------380.......390--.....------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------------MAD
N
L
Y
L
Y
----KG
S
V
K
I
T
E
M
T
L
N-LNE
A
K
-----------------
I
I
V
Y
E--DSGG
N
K
Y
T
LDASGISTL----TNIDD-
I
---------------
K
L
S
D
L
LEG
K
V
K
F
--------------
I
Y
Q
--------------KKDS
N
A
I
--------
Q
I
KG
L
G
N
I
I
S
T
L
L
A
T
-
Q
KAVD
G
E
S
I
L
A
E
E
--VS---K-K
P
V
V
D
T
I
L
K
A
T
D
-----
L
VNLN
K
N
I
V
E
T
E
L
E
D
---
K
F
V
K
K
D
A
S
N
L
T
D
A
V
N
Q
-----
K
A
--
F
A
E
--KILPAKDG
Q
K
S
I
L
V
E
K
-----
L
G
G
L
LGEPG------------AVYGDSNP
K
I
T
A
K
D
F
L
A
E
K
A
S
L
VKTDGS
N
I
V
T------QTDK--
G
K
A
L
V
------
E
A
I
L
NAK--EPISNK
E
V
K
I
V
E
T
----
E
L
A
K
T
F
V
K
T
A----------DLGTPAVA---------G--------------KVLDAK-DG--
Q
---
K
--------
S
I
L
V
E
-
K
---
L
G
R
F
L
---DTTST-EYSN--
Q
T
A
K
---
V
FSGE-------KG-----------TKP
T
A
E
E
V
--
V
T
K
L
L
AN--N--K
K
D
L
T
D
E
V
AQ-----------------------------------NPG
L
---
R
A
A
VTSNSGL
R
----------
G
T
V
IDNL-------------------K----GD------------TDF
K
T
D
I
T
I
Q
V
DAK---D
P
A
F
Q
G
F
V
---
R
E
I
I
SQ---------------------PSFEIPTSDDAPL--SWDWI------------------------------------------
43
Fugue
79.36
17%
-2
- C5 -
4COS
5
PKCB1_HUMAN
A:
[6-319]
---------------------------------------------------------------
R
N
D
F
Y
C
W
VCHR
E
G
Q
V
L
C
C
E
L
C
P
R
-
V
Y
H
A
K
-----------------
C
L
----------
R
L
T
S
E
P
E
G
D
W
F
C
----
P
E
C
E
K
-
I
---------------
T
V
A
E
C
I
E
T
--------------------
Q
--------------
S
K
A
M
T
M
L
--------
T
I
E
Q
L
S
Y
L
L
K
F
A
I
Q
K
-
M
K
Q
P
G
T
D
A
F
Q
K
P
V
PL
E
Q
---
H
-
P
D
Y
A
E
Y
I
F
H
P
M
D
-----
L
C
T
L
E
K
N
A
K
-------------
K
K
M
Y
G
C
T
E
A
F
L
A
-----
D
A
K
-
W
I
L
--
H
N
C
I
I
Y
N
G
G
N
H
K
L
T
Q
I
-----
A
K
V
V
I
K
I
C
E
------------
H
E
M
N
E
I
--
E
V
C
P
E
C
Y
L
A
A
C
Q
K
--------------------
R
--
D
N
W
F
C
------
E
---------
P
C
S
N
--------------
P
H
P
L
V
W
A
K
----------
L
K
G
F
P
F
W
P
---------
A
--------------
K
A
L
R
D
K
-
D
G
---------------
Q
V
D
A
R
-
F
---
F
G
Q
------
H
D
R
A
-
W
V
P
I
--
N
N
C
Y
---
L
M
S
K
E
-------
I
P
-----------
F
S
V
K
K
T
K
S
--
I
F
N
S
A
M
Q
--
E
--
M
E
V
Y
V
E
N
I
R
R
-----------------------------------
K
F
G
---------------------------
V
F
N
Y
S
-------------------
P
----
F
R
------------
T
P
Y
T
P
N
S
Q
Y
Q
M
-
L
L
---
D
P
-------------
T
N
---------------------
P
S
A
G
T
A
K
I
D
Q
E
K
V
--
K
L
---------------------------------------------
39
Fugue
76.12
13%
-6
* C8 *
1WAJ
1
?
?:
[376-903]
-----------------------------------------------------------
Q
N
K
V
I
P
Q
G
R
S
H
----
P
V
Q
P
Y
P
G
A
F
V
K
E
-
P
I
P
N
R
YK
Y
--------------
V
M
S
F
D
--
L
T
S
L
Y
P
S
I
I
R
Q
V
N
I
S
P
E
----
T
I
A
G
T
-
F
---------------
K
V
A
P
L
H
D
Y
I
N
A
V
--------------
A
E
R
PSDV
Y
S
C
S
PN
G
M
M
Y
Y
K
D
R
D
G
V
--------
V
P
T
E
I
T
K
V
F
N
Q
R
K
E
H
-
K
G
Y
M
L
A
A
Q
R
N
G
E
I
--
I
K
---
E
-
A
L
H
N
P
N
L
S
V
D
E
P
-----
L
D
V
D
Y
R
F
D
F
S
D
E
I
K
E
---
K
I
K
K
L
S
A
K
S
L
N
E
M
L
F
R
-----
A
Q
--
R
T
E
--
V
A
G
M
T
A
Q
I
N
R
K
L
L
I
N
S
-----
L
Y
G
A
L
G
N
V
W
FRYYD
L
R
N
A
T
A
I
T
T
F
G
Q
M
A
L
Q
W
I
E
R
K
V
N
E
Y
L
N
E
V
C
G
T
E
G
E
A
F
V
L
------
Y
G
D
T
--
D
S
I
Y
V
S
A
D
K
I
I
D
K
V
G
E
S
K
--
F
R
D
T
N
H
W
V
D
F
L
D
K
----
F
A
R
E
R
M
E
P
A
I
----------
D
R
G
F
R
E
M
C
---------
E
Y
M
NNKQHL
M
F
M
D
R
E
A
I
A
G
P
P
-
L
G
--
S
KGI
G
--------
G
F
W
T
G
-
K
K
R
Y
A
L
N
V
W
---
D
M
E
G
T
-
R
Y
A
E
--
P
K
L
K
---
I
M
G
L
E
TQKSSTP
K
A
-----------
V
Q
K
A
L
K
E
C
--
I
R
R
M
L
Q
E
--
G
--
E
E
S
L
Q
E
Y
F
K
E
F
E
K
E
F
RQLNYISI
A
S
V
S
S
ANNIAKYDVGG
F
P
G
P
KC
P
F
H
I
---
R
G
I
L
T
Y
N
R
A
I
K
GNIDAPQVVE
G
E
K
V
Y
V
L
P
L
R
E
GNPFGDK
C
I
A
W
P
SGT
E
----
I
T
------------
D
L
I
K
D
D
V
L
H
W
M
D
Y
T
V
L
L
E
K
T
F
I
K
P
L
---
E
G
F
T
S
A
---------------------
A
K
L
D
Y
E
K
K
A
S
L
F
D
--
M
F
D
F
-------------------------------------------
45
Fugue
72.02
19%
12
- C4 -
1Q9J
-
PAPA5_MYCTU
A:
[1-418]
--------------------------------------------------------------------
M
F
----
P
G
S
V
I
R
K
---
L
S
-
H
S
E
E
V
-----------------
F
A
Q
Y
E
---------
V
F
T
S
M
T
I
Q
L
R
----
G
V
I
D
V
-
D
---------------
A
L
S
D
A
F
D
A
L
L
E
T
--------------------------------
H
P
V
L
A
S
--------
H
L
E
Q
S
S
D
G
G
W
N
L
V
A
D
-
D
L
L
H
S
G
I
C
V
I
D
A
E
--
L
R
L
D
Q
S
-
V
S
L
L
H
L
Q
L
I
L
R
E
G
G
A
E
L
T
L
Y
L
H
H
C
M
A
D
G
H
H
G
A
---
V
L
V
D
E
L
F
S
R
Y
T
D
A
V
T
T
----------------------------------------
G
D
P
G
------------
P
I
T
P
Q
P
T
P
-
L
S
M
E
A
V
L
A
Q
R
G
---
I
R
K
A
E
R
F
M
S
------
V
M
Y
A
--
Y
P
G
L
P
------
Q
A
V
-------
P
V
T
R
L
W
L
S
K
Q
Q
T
----
S
D
L
M
A
F
G
R
E
H
----------
R
L
S
L
N
A
V
V
---------
A
--------------
A
A
I
L
L
T
-
E
W
--
Q
---
L
RNTPH
V
P
I
P
Y
V
Y
P
-
V
---
D
L
R
F
V
LAP
P
V
A
P
T
-
E
A
T
N
L-
L
G
A
A
---
S
Y
L
A
E
-------
I
G
-----------
P
N
T
D
I
V
D
L
--
A
S
D
I
V
A
T
--
L
--
R
A
D
L
A
N
G
V
I
Q
-----------------------------------
Q
S
G
L
HFG
T
A
F
E
G
T
P
P
G
L
P
----------
P
L
V
F
C
T
D
-------------------
A
----
T
S
F
P
T
M
R
T
P
PGLEI
E
D
I
K
G
Q
F
Y
C
S
I
S
V
P
---
L
D
L
Y
S
C
A
V
Y
AG
Q
L
I
I
E
H
---------------------
H
G
H
I
A
E
P
G
K
S
L
E
A
--
I
R
S
L
L
C
T
V
P
S
EYG----------------------------------
42
Fugue
63.92
15%
5
* C5 *
3ZPJ
-
?
A:
[1-356]
-------------------------------------------------------------------
M
T
T
----
L
E
E
I
N
L
L
V
E
R
G
Y
-
Y
E
E
A
L
-----------------
A
K
V
Y
E
I-
E
D
P
I
E
Q
V
Q
V
L
T
K
I
V
V
T
I
----
Y
Q
H
D
G
P
M
---------------
E
W
I
P
S
I
M
E
D
A
M
Y
--------------
I
A
K
--------------
K
L
R
D
P
A
N
--------
K
A
V
A
Y
S
I
I
A
S
T
L
A
I
M
-
E
Y
E
E
D
A
M
D
F
F
N
R
A
--
I
D
---
E
A
N
E
I
E
S
P
I
E
K
G
M
V
-----
L
S
T
L
A
Y
H
L
A
I
A
G
Y
P
D
---
N
A
L
E
I
F
N
I
A
F
D
T
I
I
G
A
-----------------
E
T
S
Y
T
H
K
V
D
G
I
L
R
-----
I
G
D
L
L
E
K
A
G
------------
D
----
T
L
P
S
N
E
A
M
D
F
Y
K
M
A
F
D
I
F
D
K
----------------
L
--
H
V
N
Q
R
------
A
A
I
V
E
K
K
--
I
E
L
A
K
T
V
Y
D
V
G
L
P
----
Q
I
R
A
A
L
L
K
--------------
G
K
N
H
Y
A
---------
L
--------------
A
I
I
K
K
K
Y
S
G
--
V
---
M
--------
R
L
I
G
E
L
E
---
V
A
L
W
M
---
K
R
V
N
N
M
E
Y
L
D
--
V
V
D
K
---
A
F
E
C
C
-------
E
S
-----------
P
R
F
T
D
V
N
V
Q
H
I
A
R
L
L
T
E
L
G
N
--
L
R
R
A
L
K
F
A
K
E
-----------------------------------
I
Q
N
I
---
H
K
R
S
E
A
L
K
A
I
A
----------
L
E
L
V
R
R
K
-------------------
K
--------------------
F
E
E
V
K
K
I
I
E
S
I
P
---
D
P
K
I
R
E
E
A
---
L
N
E
I
G
T
---------------------
I
E
------------------------------------------------------------
37
Fugue
63.03
13%
15
- C3 -
2Q06
-
?
A:
[22-496]
A
T
E
I
R
A
S
V
G
R
M
V
G
G
I
G
R
F
Y
I
Q
M
C
T
E
L
KLS
D
Q
E
G
R
L
I
Q
N
S
I
T
I
E
R
M
V
L
S
A
F
DERRNRYKDPK
K
T
G
G
P
I
Y
R
R
----
R
D
G
K
W
V
R
E
L
I
L
Y
D
K
E
E
I
R
-----------------
R
I
W
R
Q
--
A
N
N
G
E
D
A
T
A
G
L
T
H
M
M
I
W
H
---
S
N
L
N
D
-
A
T
YQR
T
R
A
L
V
R
T
GMDP
R
M
C
S
L
M
Q
G
S
T
----------------
L
P
R
--------------
R
S
G
A
A
G
A
--------
A
I
K
G
V
G
T
M
V
M
E
L
I
R
M
I
K
R
G
I
N
D
R
N
F
W
R
G
E
--
N
G
---
R
-
R
T
R
I
A
Y
E
R
M
C
N
I
-----
L
K
G
K
F
Q
T
A
A
Q
K
A
M
M
D
---
Q
V
R
E
S
R
N
P
G
N
A
E
I
E
D
L
-----
I
F
--
L
A
R
S
A
L
I
L
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G
S
I
A
H
K
S
C
L
P
A
C
-----
V
Y
G
L
A
V
A
S
G
------------
Y
D
F
E
R
E
G
Y
S
L
V
G
I
D
P
F
R
L
L
Q
---
N
S
Q
V
F
S
L
I
R
------
P
N
E
N
--
P
A
H
K
S
------
Q
L
V
W
M
A
C
--
H
S
A
A
F
E
D
L
R
V
S
S
F
----
I
R
G
T
R
V
I
P
R
G
----------
Q
L
S
T
R
G
V
Q
I--------
A
--------------
S
N
E
N
V
E
-
A
M
--
D
---
S
--------
S
T
L
E
L
-
R
---
S
R
Y
W
A
---
I
R
T
R
S
-
G
G
N
T
--
N
Q
Q
R
---
A
S
A
G
Q
-------
I
S
-----------
V
Q
P
T
F
S
----
V
Q
R
N
L
P
F
--
E
--
R
A
T
I
M
A
A
F
K
G
-----------------------------------
N
T
E
G
---
R
T
-----
S
D
M
R
----------
T
E
I
I
R
M
M
-------------------
E
S
ARP
E
D
------------
V
S
F
Q
G
R
G
V
F
E
L
S
D
E
---
K
A
T
N
P
----------
I
V
---------------------
P
S
F
D
M
S
N
E
G
S
Y
F
F
GD
N
A
E
E
Y
------------------------------------------
7
PsiBlast_PDB
62.72
25%
19
* C11 *
4RJK
6
?
A:
[46-235]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
Q
D
-----
K
G
---
P
E
--
I
I
V
A
R
H
E
Q
N
A
A
F
M
A
Q
A
-----
V
G
R
L
T
G
K
P
G
------------
V
V
L
V
T
S
G
P
G
A
S
N
---
L
A
T
G
L
L
T
A
N
T
E
G
D
P
V
V
A
L
A
G
N
V
I
R
A
D
R
--
L
K
R
T
H
------
Q
S
L
D
N
A
A
L
F
Q
P
I
T
K
Y
S
V
E
V
Q
D
V
KN
I
P
E
A
V
T
N
A
F
R
I
A
----------
S
A
G
Q
A
G
A
A
F
V
S
F
P
Q
D
V
V
N
--------------
E
V
T
N
T
K
-
N
---
V
---
R
--------
A
V
A
A
P
-
K
---
L
G
P
A
A
---
D
D
A
I
S
-
A
A
I
A
K
I
Q
T
A
K
L
P
V
V
L
V
G
M
-------
K
G
-----------
G
R
P
E
A
I
K
A
--
V
R
K
L
L
K
K
--
V
--
Q
L
P
F
V
E
T
Y
Q
A
-----------------------------------
A
G
T
L
---
S
R
D
L
E
D
Q
Y
F
G
R
----------
I
G
L
F
R
N
Q
-------------------
P
----
G
D
------------
L
L
L
E
Q
A
D
V
V
L
T
I
G
Y
---
D
P
I
E
Y
D
P
K
---
F
W
N
I
N
G
---------------------
D
R
T
I
I
H
L
D
E
I
I
A
D
--
I
D
H
A
Y
------------------------------------------
8
PsiBlast_PDB
61.83
25%
22
- C11 -
4RJI
1
?
A:
[46-235]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
Q
D
-----
K
G
---
P
E
--
I
I
V
A
R
H
E
Q
N
A
A
F
M
A
Q
A
-----
V
G
R
L
T
G
K
P
G
------------
V
V
L
V
T
S
G
P
G
A
S
N
---
L
A
T
G
L
L
T
A
N
T
E
G
D
P
V
V
A
L
A
G
N
V
I
R
A
D
R
--
L
K
R
T
H
------
Q
S
L
D
N
A
A
L
F
Q
P
I
T
K
Y
S
V
E
V
Q
D
V
KN
I
P
E
A
V
T
N
A
F
R
I
A
----------
S
A
G
Q
A
G
A
A
F
V
S
F
P
Q
D
V
V
N
--------------
E
V
T
N
T
K
-
N
---
V
---
R
--------
A
V
A
A
P
-
K
---
L
G
P
A
A
---
D
D
A
I
S
-
A
A
I
A
K
I
Q
T
A
K
L
P
V
V
L
V
G
M
-------
K
G
-----------
G
R
P
E
A
I
K
A
--
V
R
K
L
L
K
K
--
V
--
Q
L
P
F
V
E
T
Y
Q
A
-----------------------------------
A
G
T
L
---
S
R
D
L
E
D
Q
Y
F
G
R
----------
I
G
L
F
R
N
Q
-------------------
P
----
G
D
------------
L
L
L
E
Q
A
D
V
V
L
T
I
G
Y
---
D
P
I
E
Y
D
P
K
---
F
W
N
I
N
G
---------------------
D
R
T
I
I
H
L
D
E
I
I
A
D
--
I
D
H
A
Y
------------------------------------------
44
Fugue
61.41
11%
-2
- C8 -
1IH7
1
DPOL_BPR69
A:
[360-903]
------------------------------------------------------S
P
I
K
T
W
D
A
I
I
F
N
S
L
K
E
----
Q
N
K
V
I
P
Q
G
R
S
H
P
-
V
Q
---PYP
G
A
F
V
K
EPI
P
N
R
Y
K
Y
V
M
S
F
D
--
L
T
S
L
Y
P
S
I
I
R
Q
V
N
I
S
P
E
----
T
I
A
G
T
-
F
---------------
K
V
A
P
L
H
D
Y
I
N
A
V
AERPSDV
Y
S
C
S
PNG
M
M
Y
--------------
Y
K
D
R
D
G
V
--------
V
P
T
E
I
T
K
V
F
N
Q
R
K
E
H
-
K
G
Y
M
L
A
A
Q
R
N
G
E
I
--
I
K
---
E
-
A
L
H
N
P
N
L
S
V
D
E
P
-----
L
D
V
D
Y
R
F
D
F
S
D
E
I
K
E
---
K
I
K
K
L
S
A
K
S
L
N
E
M
L
F
R
-----
A
Q
--
R
T
E
--
V
A
G
M
T
A
Q
I
N
R
K
L
L
I
N
S
-----
L
Y
G
A
L
G
N
V
W
FRYYD
L
R
N
A
T
A
I
T
T
F
G
Q
M
A
L
Q
W
I
E
R
K
V
N
E
Y
L
N
E
V
C
G
T
E
G
E
A
F
V
L
------
Y
G
D
T
--
D
S
I
Y
V
S
A
D
K
I
I
D
K
V
G
E
S
K
--
F
R
D
T
N
H
W
V
D
F
L
D
K
----
F
A
R
E
R
M
E
P
A
I
----------
D
R
G
F
R
E
M
C
---------
E
Y
M
NNKQHLM
F
M
D
R
E
A
I
A
G
P
P
-
L
G
--
S
KG-
I
--------
G
G
F
W
T
-
G
---
K
K
R
Y
A
---
L
N
V
W
D
-
M
E
G
T
--
R
Y
A
E
---
P
K
L
K
I
-------
M
G
LETQKSSTP
K
A
V
Q
K
A
L
K
E
C
--
I
R
R
M
L
Q
E
-----
G
E
E
S
L
Q
E
Y
F
K
-----------------------------------
E
F
E
K
---
E
F
R
Q
L
N
Y
I
S
I
A
----------
S
V
S
S
A
N
N
-------------------
I
----
A
K
------------
Y
D
V
G
G
F
P
G
P
K
C
P
F
H
---
I
R
G
I
L
T
Y
N
---
R
A
I
P
--QVVEG
E
K
V
Y
V
L
P
L
R
E
GNPFGD
K
C
I
A
W
P
S
G
T
E
I
T
D
--
L
I
K
D
D
V
L
H
W
MD
Y
T
V
L
L
E
K
TF
I
K
P
L
E
G
F
T
S
A
A
KLDYEKKASLFDMFDF
6
PsiBlast_PDB
59.39
25%
21
- C11 -
4RJJ
4
?
A:
[46-235]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
Q
D
-----
K
G
---
P
E
--
I
I
V
A
R
H
E
Q
N
A
A
F
M
A
Q
A
-----
V
G
R
L
T
G
K
P
G
------------
V
V
L
V
T
S
G
P
G
A
S
N
---
L
A
T
G
L
L
T
A
N
T
E
G
D
P
V
V
A
L
A
G
N
V
I
R
A
D
R
--
L
K
R
T
H
------
Q
S
L
D
N
A
A
L
F
Q
P
I
T
K
Y
S
V
E
V
Q
D
V
KN
I
P
E
A
V
T
N
A
F
R
I
A
----------
S
A
G
Q
A
G
A
A
F
V
S
F
P
Q
D
V
V
N
--------------
E
V
T
N
T
K
-
N
---
V
---
R
--------
A
V
A
A
P
-
K
---
L
G
P
A
A
---
D
D
A
I
S
-
A
A
I
A
K
I
Q
T
A
K
L
P
V
V
L
V
G
M
-------
K
G
-----------
G
R
P
E
A
I
K
A
--
V
R
K
L
L
K
K
--
V
--
Q
L
P
F
V
E
T
Y
Q
A
-----------------------------------
A
G
T
L
---
S
R
D
L
E
D
Q
Y
F
G
R
----------
I
G
L
F
R
N
Q
-------------------
P
----
G
D
------------
L
L
L
E
Q
A
D
V
V
L
T
I
G
Y
---
D
P
I
E
Y
D
P
K
---
F
W
N
I
N
G
---------------------
D
R
T
I
I
H
L
D
E
I
I
A
D
--
I
D
H
A
Y
------------------------------------------
40
Fugue
58.99
13%
12
- C2 -
3EDV
5
SPTB2_HUMAN
A:
[2-323]
--------------------------------------------------------------
S
H
M
R
H
R
L
F
----
Q
L
N
R
E
V
D
D
L
E
Q
W
-
I
A
E
R
E
-----------------
V
V
A
G
S
--
H
E
L
G
Q
-------------------
D
Y
-
E
---------------
H
V
T
M
L
Q
E
R
F
R
E
F
--------------
A
R
D
--------------
T
G
N
I
G
Q
E
--------
R
V
D
T
V
N
H
L
A
D
E
L
I
N
S
-
G
H
--
S
D
A
A
T
I
A
E
W
-------
K
-
D
G
L
N
E
A
W
A
D
L
L
E
-----
L
I
D
T
R
T
Q
I
L
A
A
S
Y
E
L
---
H
K
F
Y
H
D
A
K
E
I
F
G
R
I
Q
D
-----
K
H
--
K
K
-----
L
P
E
E
L
G
R
D
--------------------------------------------
Q
N
T
V
E
T
L
Q
R
M
H
T
T
F
E
H
D
I
Q
A
------
L
G
T
Q
--
V
R
Q
L
Q
------
E
D
A
A
R
L
Q
--
A
A
Y
A
G
D
K
A
D
D
I
Q
K
----
R
E
N
E
V
L
E
A
W
K
----------
S
L
L
D
A
C
E
S
---------
R
--------------
R
V
R
L
V
D
-
T
G
--
D
---
K
--------
F
R
F
F
S
-
M
---
V
R
D
L
M
---
L
W
M
E
D
-
V
I
R
Q
--
I
E
A
Q
----------------------------
E
K
P
R
D
V
S
S
--
V
E
L
L
M
N
N
--
H
--
Q
G
I
K
A
E
I
D
A
R
-----------------------------------
N
D
S
F
---
T
T
C
I
E
L
G
K
S
L
L
----------
A
R
--------------------------------------------------------
K
---
H
Y
A
S
E
E
I
K
---
E
K
L
L
Q
L
---------------------
T
E
K
R
K
E
M
I
D
K
W
E
D
--
R
W
E
W
L
R
L----------------------------------------
46
Fugue
55.55
10%
3
- C5 -
1T6C
11
?
A:
[10-315]
---------------------------------------------------------------------------
P
I
M
R
V
A
S
I
D
I
G
-
S
Y
S
V
R
-----------------
L
T
I
A
Q
--
I
K
D
G
---------------------
K
-
L
---------------
S
I
I
L
E
R
G
R
I
T
S
L
--------------
G
T
K
--------------
V
K
E
T
G
R
L
--------
Q
E
D
R
I
E
E
T
I
Q
V
L
K
E
Y
-
K
K
L
I
D
E
F
K
V
E
R
V
K
--
A
V
---
A
-
T
E
A
I
R
R
A
K
N
A
E
E
-----
F
L
E
R
V
K
R
E
V
G
L
V
V
E
V
------------
I
T
P
E
Q
E
G
-----
R
Y
--
A
Y
L
--
A
V
A
Y
S
L
K
P
E
G
E
V
C
V
V
D
-----
Q
G
G
-----------------------------------
G
S
T
E
Y
V
F
G
K
G
Y
K
V
R
E
------
V
I
S
L
PI
G
I
V
N
L
------
T
E
T
F
F
K
Q
--
D
P
P
T
E
E
E
V
K
R
F
F
E
----
F
L
E
K
E
L
S
K
V
K
-----------------------------------------------
K
-
P
V
--
D
---
T
--------
I
V
G
L
G
-
G
---
T
I
T
T
L
---
A
A
L
E
Y
-
N
V
Y
P
--
Y
D
P
Q
---
K
V
H
G
K
-------
V
L
-----------
T
Y
G
Q
I
K
K
W
--
F
D
T
F
K
E
I
--
P
--
S
E
E
R
S
K
R
F
--------------------------------------
R
Q
V
---
E
D
R
R
A
K
V
I
L
A
G
----------
I
G
I
F
L
K
T
-------------------
L
----
E
I
------------
F
E
K
D
C
L
I
V
S
D
W
G
L
R
---
E
G
V
L
V
S
E
V
---
L
K
E
N
H
S
-----------------------------------------------------------------------------------
4
PsiBlast_PDB
52.80
30%
31
* C10 *
1R45
2
ARC3_CBCP
A:
[93-170]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------
Y
L
G
-
P
E
F
Q
---------
D
--------------
K
I
L
N
-
K
-
D
G
TI
N
---
K
--------
T
V
F
E
Q
-
V
---
K
A
K
F
L
---
K
K
D
R
T
-
E
Y
G
Y
--
I
S
T
S
---
L
M
S
A
Q
-------
F
G
-----------
G
R
P
----
I
--
V
T
K
F
K
V
T
--
N
G
S
K
G
G
Y
I
D
P
I
S
Y
-----------------------------------
F
P
G
Q
---
L
E
V
L
L
P
R
N
N
S
Y
----------
Y
I
S
D
M
Q
I
-------------------
S
----
P
N
------------
N
R
Q
I
M
I
T
A
M
I
F
K
---------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
51.26
30%
38
- C10 -
1R4B
-
ARC3_CBCP
A:
[133-210]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------
Y
L
G
-
P
E
F
Q
---------
D
--------------
K
I
L
N
-
K
-
D
G
TI
N
---
K
--------
T
V
F
E
Q
-
V
---
K
A
K
F
L
---
K
K
D
R
T
-
E
Y
G
Y
--
I
S
T
S
---
L
M
S
A
Q
-------
F
G
-----------
G
R
P
----
I
--
V
T
K
F
K
V
T
--
N
G
S
K
G
G
Y
I
D
P
I
S
Y
-----------------------------------
F
P
G
Q
---
L
E
V
L
L
P
R
N
N
S
Y
----------
Y
I
S
D
M
Q
I
-------------------
S
----
P
N
------------
N
R
Q
I
M
I
T
A
M
I
F
K
---------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
50.41
24%
2
- C6 -
1A6D
-
THSA_THEAC
A:
[129-352]
------------------------------------------------------------------------------------
L
A
-
V
N
E
A
R
-----------------
K
I
I
D
E
I
A
E
K
S
T
D
D
A
T
L
R
K
I
A
L
T
A
L
SGKN
T
G
L
S
N
-
D
---------------
F
L
A
D
L
V
V
K
A
V
N
A
--------------
V
A
E
--------------
V
R
D
G
K
T
I
V
DTAN
I
K
V
D
K
K
N
G
G
S
V
N
D
T
Q
F
I
S
-
G
I
V
I
D
K
E
K
V
H
------
S
---
K
-
M
P
D
V
V
K
N
A
K
I
A
------
L
I
D
S
A
L
E
I
K
K
T
E
I
E
A
---
K
V
Q
I
S
D
P
S
K
I
Q
D
F
L
N
Q
E
T
N
T
F
K
Q
--
M
V
E
--
K
I
--
K
K
S
G
A
N
V
V
L
C
Q
K
G
I
D
D
V
A
Q
H
Y
L
A
K
E
G
-------------
I
Y
A
V
R
R
V
K
K
S
D
M
E
K
L
A
------
K
A
T
G
A
K
I
V
T
------
D
L
D
D
-----
L
T
------
P
S
V
L
G
E
A
--
E
T
V
E
E
R
K
I
G
D
D
R
M
----
T
F
V
M
G
C
K
N
P
K
----------
A
V
S
I
L
I
R
G
---------
G
--------------
T
D
H
V
V
S
-
E
V
--
E
---
R
--------
A
L
N
D
A
-
I
---
R
V
V
A
I
---
T
K
E
D
G
-
K
F
L
W
--
G
G
G
A
---
V
E
A
E
L
-------
A
M
-----------
R
L
A
K
Y
A
N
S
--
V
G
G
R
E
Q
L
--
A
--
I
E
A
F
A
K
A
L
E
I
-----------------------------------
I
P
R
T
---
L
A
E
N
A
G
I
D
P
I
N
----------
T
L
I
K
L
K
A
-------------------
D
----
D
E
------------
K
G
R
I
S
V
G
V
D
L
D
N
N
G
---
V
G
D
M
K
A
K
G
---
V
V
D
P
L
R
---------------------
V
K
T
H
A
L
E
S
A
V
E
V
A
--
T
M
I
L
R
------------------------------------------
24
PsiBlast_CBE
47.90
41%
22
- C7 -
3K5I
2
?
D:
[214-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
K
T
K
D
-----
E
V
-
L
S
Y
P
T
V
E
T
V
Q
E
D
SIC
K
L
V
Y
A
P
A
R
N
V
S
D
A
I
N
Q
-----
K
A
QE
L
A
R
--
K
A
V
A
A
F
D
G
K
G
V
F
G
V
E
M
-----
F
L
L
E
D
D
S
I
M
------------
L
C
E
I
A
S
R
I
H
N
S
G
H
Y
T
I
E
G
C
A
L
S
Q
F
D
A
H
L
R
A
I
L
------
D
L
P
I
--
P
A
Q
S
L
------
E
I
R
Q
P
S
I
--
M
L
N
I
I
G
G
A
A
P
D
T
H
----
L
Q
A
A
E
C
A
L
S
I
----------
P
N
A
S
I
H
L
Y
---------
S
--------------
K
G
A
A
K
P
-
G
R
--
K
---
M
--------
G
H
I
T
V
-
T
---
A
P
T
M
H
---
E
A
E
T
H
-
I
Q
P
L
--
I
D
V
V
---
D
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
46.60
27%
19
- C9 -
2VHY
-
DHA_MYCTU
A:
[33-130]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
I
Q
A
G
------------
A
G
E
G
S
A
---
I
T
D
A
D
F
K
A
A
G
A
Q
L
V
G
T
--------------
A
D
Q
--
V
W
A
D
A
------
D
L
L
L
K
V
K
--
E
P
I
A
A
E
Y
G
R
L
R
H
G
----
Q
I
L
F
T
F
L
H
L
A
AS
R
A
C
T
D
A
L
L
D
S
G
T
T
S
I
A
---------
Y
--------------
E
T
V
Q
T
A
-
D
G
--
A
---
L
--------
P
L
L
A
P
-
M
---
S
E
V
A
G
---
R
L
A
A
Q
-
V
G
A
Y
--
H
L
M
R
---
T
Q
G
G
R
-------
G
V
-----------
L
M
G
G
V
P
G
V
--
E
P
A
D
V
V
V
--
I
--
G
A
G
T
A
G
Y
N
A
A
-----------------------------------
R
I
A
N
---
G
M
G
A
T
V
T
V
L
D
I
----------
N
I
D
K
L
R
Q
-------------------
L
----
D
A
------------
E
F
C
G
R
I
H
T
R
Y
S
S
A
Y
---
E
L
E
G
A
V
K
R
---
A
D
L
V
I
G
---------------------
A
V
M
K
P
G
A
V
L
V
D
I
A
--
L
F
Y
C
M
------------------------------------------
11
PsiBlast_PDB
45.98
27%
18
- C9 -
2VOE
-
DHA_MYCTU
A:
[33-130]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
I
Q
A
G
------------
A
G
E
G
S
A
---
I
T
D
A
D
F
K
A
A
G
A
Q
L
V
G
T
--------------
A
D
Q
--
V
W
A
D
A
------
D
L
L
L
K
V
K
--
E
P
I
A
A
E
Y
G
R
L
R
H
G
----
Q
I
L
F
T
F
L
H
L
A
AS
R
A
C
T
D
A
L
L
D
S
G
T
T
S
I
A
---------
Y
--------------
E
T
V
Q
T
A
-
D
G
--
A
---
L
--------
P
L
L
A
P
-
M
---
S
E
V
A
G
---
R
L
A
A
Q
-
V
G
A
Y
--
H
L
M
R
---
T
Q
G
G
R
-------
G
V
-----------
L
M
G
G
V
P
G
V
--
E
P
A
D
V
V
V
--
I
--
G
A
G
T
A
G
Y
N
A
A
-----------------------------------
R
I
A
N
---
G
M
G
A
T
V
T
V
L
D
I
----------
N
I
D
K
L
R
Q
-------------------
L
----
D
A
------------
E
F
C
G
R
I
H
T
R
Y
S
S
A
Y
---
E
L
E
G
A
V
K
R
---
A
D
L
V
I
G
---------------------
A
V
L
V
P
G
A
K
A
P
K
L
V
--
S
N
S
L
V
------------------------------------------
26
PsiBlast_CBE
45.83
41%
17
* C7 *
3K5I
2
?
B:
[214-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
K
T
K
D
-----
E
V
-
L
S
Y
P
T
V
E
T
V
Q
E
D
SIC
K
L
V
Y
A
P
A
R
N
V
S
D
A
I
N
Q
-----
K
A
Q
E
L
A
R
--
K
A
V
A
A
F
D
G
K
G
V
F
G
V
E
M
-----
F
L
L
E
D
D
S
I
M
------------
L
C
E
I
A
S
R
I
H
N
S
G
H
Y
T
I
E
G
C
A
L
S
Q
F
D
A
H
L
R
A
I
L
------
D
L
P
I
--
P
A
Q
S
L
------
E
I
R
Q
P
S
I
--
M
L
N
I
I
G
G
A
A
P
D
T
H
----
L
Q
A
A
E
C
A
L
S
I
----------
P
N
A
S
I
H
L
Y
---------
S
--------------
K
G
A
A
K
P
-
G
R
--
K
---
M
--------
G
H
I
T
V
-
T
---
A
P
T
M
H
---
E
A
E
T
H
-
I
Q
P
L
--
I
D
V
V
---
D
R
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
45.34
27%
16
- C9 -
2VHV
1
DHA_MYCTU
A:
[33-130]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
I
Q
A
G
------------
A
G
E
G
S
A
---
I
T
D
A
D
F
K
A
A
G
A
Q
L
V
G
T
--------------
A
D
Q
--
V
W
A
D
A
------
D
L
L
L
K
V
K
--
E
P
I
A
A
E
Y
G
R
L
R
H
G
----
Q
I
L
F
T
F
L
H
L
A
AS
R
A
C
T
D
A
L
L
D
S
G
T
T
S
I
A
---------
Y
--------------
E
T
V
Q
T
A
-
D
G
--
A
---
L
--------
P
L
L
A
P
-
M
---
S
E
V
A
G
---
R
L
A
A
Q
-
V
G
A
Y
--
H
L
M
R
---
T
Q
G
G
R
-------
G
V
-----------
L
M
G
G
V
P
G
V
--
E
P
A
D
V
V
V
--
I
--
G
A
G
T
A
G
Y
N
A
A
-----------------------------------
R
I
A
N
---
G
M
G
A
T
V
T
V
L
D
I
----------
N
I
D
K
L
R
Q
-------------------
L
----
D
A
------------
E
F
C
G
R
I
H
T
R
Y
S
S
A
Y
---
E
L
E
G
A
V
K
R
---
A
D
L
V
I
G
---------------------
A
V
L
V
P
G
A
K
A
P
K
L
V
--
S
N
S
L
V
------------------------------------------
16
PsiBlast_PDB
45.28
27%
22
- C9 -
2VHX
1
DHA_MYCTU
A:
[33-130]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
I
Q
A
G
------------
A
G
E
G
S
A
---
I
T
D
A
D
F
K
A
A
G
A
Q
L
V
G
T
--------------
A
D
Q
--
V
W
A
D
A
------
D
L
L
L
K
V
K
--
E
P
I
A
A
E
Y
G
R
L
R
H
G
----
Q
I
L
F
T
F
L
H
L
A
AS
R
A
C
T
D
A
L
L
D
S
G
T
T
S
I
A
---------
Y
--------------
E
T
V
Q
T
A
-
D
G
--
A
---
L
--------
P
L
L
A
P
-
M
---
S
E
V
A
G
---
R
L
A
A
Q
-
V
G
A
Y
--
H
L
M
R
---
T
Q
G
G
R
-------
G
V
-----------
L
M
G
G
V
P
G
V
--
E
P
A
D
V
V
V
--
I
--
G
A
G
T
A
G
Y
N
A
A
-----------------------------------
R
I
A
N
---
G
M
G
A
T
V
T
V
L
D
I
----------
N
I
D
K
L
R
Q
-------------------
L
----
D
A
------------
E
F
C
G
R
I
H
T
R
Y
S
S
A
Y
---
E
L
E
G
A
V
K
R
---
A
D
L
V
I
G
---------------------
A
V
L
V
K
A
P
K
L
V
S
N
S
--
L
V
A
H
M
------------------------------------------