@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0010: (2015-11-27 )
MKKFTYTRTALASLLTLCSFSGFAADSFNEGMKGVKKQENIKSITTSEKMEVMKTSNKRLKEKMDRICNADPRKKAEELKKKEELKLAAEKKKEELAEKKRKETKLASEKKAKPLDAKNSNVESSKTRGTETQKARDVKKNFKKDVKIVGQNAEKKGEASPVILVGGVDVIDTNQGTSGLKITFGGVVDAQGYGKAGPSGEDYKHYNVMSGKSTGYYEDISDKVKGANPIFPSGIGNIGDYSEDIDMIADAILHLRAEDKNEDKGLLYGADVQFQVPVTEGKGASQGVRATRGRSAHVFLSSRYGDLKLGYQFGPEALMRLDATRIATIDGAADSDWFRKVNLEGSAASFPFYVTPRLYTESFSSESEKLSFRMAGKYHKNVMTTLPFRFAYYSPNYMGARFGVSYSPRYDSNLFVIKDGDNIKHVGPDYEHIVSAGASYEYDFSERKVKVKVAAVGEYGQAKEPDSTKYAYKEYVEYNDLMGVNLGISADCNINEDQGVKFAASFAYLGKSGQPKGIEKLVGNVYQKIDGKGVTDDDKRVKELEDQFKGDDKNTMYWTAGAGYQHENFYISLTYFGSKMSDGDKLHDVAFGIQYDLSPASSKGKFVPYASLHYFKTDEKQGGGYKITKKDSSGIAPSNQGVLFLTGMKFSF
Atome Classification :
(20 SA)
.........10........20........30.....--...-40......--..50........60........70........80..--......90........100.....--------..110.......120.......130.-..--....140.......150.......160..----.....170.......180.......190.......200.......210.......220....-...230.......240.......250.......260.......270.......280.......290.......300........310.......320.......330.......340.......350.-......360.......370.......380.......390.....----.----.400.......410......-.--420.......430.......440.......450...---....460.......470.......480.......490.......500--.......510.......520.......530.......540...-..-..550.......560......-----.570...------------....580------.-------.----...--.--..590......----.600...------------....610.......620.......630.......640.......650
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKK
F
T
Y
T
R
T
A
L
A
S
L
L
T
L
CSFSGFA
A
D
S
F
N
E
G
M
KG
V
K
--
K
Q
E
-
N
I
K
SI
T
T
S
--
E
K
M
E
V
M
KTS
N
K
R
L
K
E
K
M
D
R
I
CNAD
P
R
K
K
A
E
E
L
K
K
K
E
--
E
L
K
L
A
A
E
K
K
K
E
E
L
A
E
K
K
R
K
E
TKLA--------SEKKAKPLDAKNSNVESSKTRGT
E
T
Q
-
K
A
--
R
D
V
K
K
N
F
K
K
D
V
K
IVGQNAEKKGEAS
P
V
I
L
----VGG
V
D
V
I
DTNQGTS
G
L
K
I
T
FG
G
V
VDAQGYGKAGPSGEDY
K
H
Y
NVMSGKSTG
Y
Y
E
D
I
S
D
KVKG-ANPIFPSGIGNIGD
Y
S
E
D
I
D
M
I
A
D
A
I
L
H
LRAEDKNEDK
G
L
L
YGAD
V
Q
F
Q
V
PVTEGKGASQGVRATRGR
S
A
H
V
F
L
S-SRYG
D
L
K
L
G
Y
QF
G
P
E
A
L
M
R
LDA
T
R
I
A
T
IDGAAD
S
D
W
F
R
K
VNLEGSAASF
P
F
Y
-VT
P
R
L
YTESFSSES
E
K
L
S
F
R
MAGKYHKN
V
M
T
TL
P
F
R
F
A
YYSPNY----M----GARFG
V
S
YSPRYDS
N
L
F
V
I
K-D--GDNIKHVGP
D
Y
E
H
I
V
SAGA
S
Y
E
YDFSE
R
K
V
K
V
K
V
A
A
---VGEYGQAKEPDS
T
K
Y
A
Y
K
E
Y
VEYND
L
M
G
VNLGISADCNIN
E
D
QG
V
K
F
--
A
A
S
F
A
Y
LGKSGQP
K
G
I
E
K
L
V
G
N
V
Y
Q
KIDGKGVT
D
D
D
K
R
V
K
E
L
E
-
D
Q
-FKGDDK
N
T
M
Y
W
TAGAG
Y
Q
H
E
N
-----
F
Y
I
S
L
T
Y
------------FGSKMS-------D-------G----DK
L
--
H
--
D
V
A
F
G
I
Q
Y
DLS----PASSKG
K
------------
F
V
P
Y
A
S
L
H
Y
F
KTDEKQGG
G
Y
K
I
T
KKDSSGIAPSNQ
G
V
L
F
LTGMKFSF
19
HHSearch
81.45
16%
-5
- C3 -
2FGQ
6
OMP32_DELAC
X:
[33-332]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
S
T
S
R
L
G
L
R
G
-
T
E
D
L
G
G
G
L
K
A
G
F
W
L
E
G
E
I
F
-
G
D
D
-
G
N
A
--
S
G
F
N
F
K
R
R
S
T
V
S
L
S
-
G
N
F
G
E
V
R
L
G
R
D
L
V
P
T
S
Q
K
L
-
T
S
Y
D
L
F
S
A
T
G
-
I
G
P
----
F
M
G
F
R
N
----------
W
A
----
A
G
Q
----
G
A
---------
D
-
D
N
G
I
R
A
N
N
L
I
S
Y
Y
T
P
N
F
----
G
----
G
F
N
A
G
F
G
Y
A
F
D
E
K
Q
T
I
G
-------------
T
A
D
S
V
G
R
Y
I
G
G
Y
V
A
Y
D
N
--
G
P
----
L
S
A
S
L
---
G
L
A
Q
Q
K
T
A
V
G
----------
G
L
A
T
D
R
D
E
I
T
L
G
A
S
Y
N
F
G
-----
V
A
K
L
--
S
G
L
L
Q
Q
T
K
F
K
R
D
---
I
---------------------------------
G
G
D
I
K
T
N
S
Y
M
L
G
A
S
A
P
V
G
G
V----
G
E
V
K
L
Q
Y
------------
A
L
Y
D
Q
K
A------
I
-------
D
----
S
K
A
--
H
--
Q
I
T
L
G
Y
V
H
N
L
S
----
K
R
-----------------
T
A
L
Y
G
N
L
A
F
L
K
N
K
D
A
S
T
L
G
L
Q
A
K
G
V
Y
A
G
G
V
Q
A
G
E
S
Q
T
G
V
Q
V
G
I
R
H
A
F
20
HHSearch
66.61
14%
-10
- C3 -
3WI5
2
OMPB1_NEIMB
A:
[36-312]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
G
S
K
I
G
F
K
G
-
Q
E
D
L
G
N
G
L
K
A
I
W
Q
V
E
Q
K
A
S
-
I
A
G
-
T
----
D
S
G
W
G
N
R
Q
S
F
I
G
L
K
-
G
G
F
G
K
L
R
V
G
R
L
N
S
V
L
K
D
T
G
D
I
N
P
------------
W
D
S
K
S
D
Y
L
G
-----------
V
N
----
K
I
-----
A
------------
E
P
E
A
R
L
I
S
V
R
Y
D
S
P
E
F
----
A
----
G
L
S
G
S
V
Q
Y
A
L
N
D
N
A
G
-----------------
R
H
N
S
E
S
Y
H
A
G
F
N
Y
K
N
--
G
G
--
F
F
V
Q
Y
G
G
---
A
Y
K
R
H
H
Q
V
Q
E
---------
G
L
N
I
E
K
Y
Q
I
H
R
L
V
S
G
Y
D
N
D
-----
A
L
Y
A
--
S
V
A
V
Q
Q
Q
D
A
K
L
T
D
A
-
S
---------------------------------
N
S
H
N
S
Q
T
E
V
A
A
T
L
A
Y
R
F
G
N
-----
V
T
P
R
V
S
Y
------------
A
H
G
F
K
G
LVAKAD-
I
-------
G
----
N
R
Y
--
D
--
Q
V
V
V
G
A
E
Y
D
F
S
----
K
R
-----------------
T
S
A
L
V
S
A
G
W
L
Q
E
G
K
G
E
---------------
N
K
F
V
A
T
A
G
G
V
G
L
R
H
K
F
23
HHSearch
65.93
16%
-10
- C3 -
2ZFG
2
OMPF_ECOLI
A:
[37-340]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
T
Y
A
R
L
G
F
K
G
-
E
T
Q
I
N
S
D
L
T
G
Y
G
Q
W
E
Y
N
F
Q
G
N
N
S
E
G
A
D
-
A
Q
T
G
N
K
T
R
L
A
F
A
G
L
K
Y
A
D
V
G
S
F
D
Y
G
R
N
Y
G
V
V
Y
D
A
L
G
-
Y
T
D
M
L
P
E
F
G
----------
G
D
---
T
---
A
--------
Y
S
D
D
F
------------------
F
V
G
R
V
G
G
V
A
T
Y
R
N
S
N
F
----
F
GLVD
G
L
N
F
A
V
Q
Y
L
G
K
N
E
R
D
T
--------------
A
R
R
S
N
G
D
G
V
G
G
S
I
S
Y
E
Y
--
E
G
----
F
G
I
V
G
---
A
Y
G
A
A
D
R
T
N
L
Q
----
E
A
Q
P
L
G
N
G
K
K
A
E
Q
W
A
T
G
L
K
Y
D
A
N
-----
N
I
Y
L
--
A
A
N
Y
G
E
T
R
N
A
T
P
I
-
T
N
K
F
-----------------
T
------
N
-
T
---
S
G
F
A
N
K
T
Q
D
V
L
L
V
A
Q
Y
Q
F
D
F
G
----
L
R
P
S
I
A
Y
------------
T
K
S
K
A
K
-------
D
VEGIGD-
V
----
D
L
V
--
N
--
Y
F
E
V
G
A
T
Y
Y
F
N
----
K
N
-----------------
M
S
T
Y
V
D
Y
I
I
N
Q
I
D
S
D
N
K
L
-------------
G
V
G
S
D
D
T
V
A
V
G
I
V
Y
Q
F
24
HHSearch
65.50
16%
-3
- C3 -
3NSG
16
OMPF_SALTY
A:
[34-341]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
T
Y
A
Q
I
G
F
K
G
-
E
T
Q
I
N
T
D
L
T
G
F
G
Q
W
E
Y
R
T
K
-
A
D
R
-
A
E
G
E
Q
Q
N
S
N
L
V
R
L
A
F
A
G
L
K
Y
A
E
V
G
S
I
D
Y
G
R
N
Y
G
I
V
Y
D
V
E
-
S
Y
T
D
M
A
P
Y
F
S
G
--
E
T
W
G
---
G
--
A
--------------
Y
T
D
N
Y
------------------
M
T
S
R
A
G
G
L
L
T
Y
R
N
S
D
F
----
F
GLVD
G
L
S
F
G
I
Q
Y
Q
G
K
N
Q
D
N
H
-------------
S
I
N
S
Q
N
G
D
G
V
G
Y
T
M
A
Y
E
F
D
--
G
----
F
G
V
T
A
---
A
Y
S
N
S
K
R
T
N
D
Q
Q
-----
D
R
D
G
N
G
D
R
A
E
S
R
A
V
G
A
K
Y
D
A
N
-----
N
V
Y
L
--
A
A
V
Y
A
E
T
R
N
M
S
I
V
-
E
N
T
V
-------------------
T
-------
D
-
T
V
E
M
A
N
K
T
Q
N
L
E
V
V
A
Q
Y
Q
F
D
F
G
----
L
R
P
A
I
S
Y
------------
V
Q
S
K
G
K
-------
Q
LNGAGGS
A
----
D
L
A
--
K
--
Y
I
Q
A
G
A
T
Y
Y
F
N
----
K
N
-----------------
M
N
V
W
V
D
Y
R
F
N
L
L
D
E
N
D
Y
S
-----------
S
S
Y
V
G
T
D
D
Q
A
A
V
G
I
T
Y
Q
F
25
HHSearch
64.15
15%
-15
- C3 -
1PHO
-
PHOE_ECOLI
A:
[39-340]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
I
R
F
G
F
K
G
-
E
T
Q
I
N
D
Q
L
T
G
Y
G
R
W
E
A
E
F
A
-
G
N
K
-
A
E
-
S
D
T
A
Q
Q
K
T
R
L
A
F
A
G
L
K
Y
K
D
L
G
S
F
D
Y
G
R
N
L
G
A
L
Y
D
V
E
A
-
W
T
D
M
F
----------
P
E
F
G
G
D
S
-
A
-------------
Q
T
D
N
F
------------------
M
T
K
R
A
S
G
L
A
T
Y
R
N
T
D
F
FGVI
D
----
G
L
N
L
T
L
Q
Y
Q
G
K
N
E
N
R
D
--------------
V
K
K
Q
N
G
D
G
F
G
T
S
L
T
Y
D
--
F
G
----
D
F
A
I
S
G
---
A
Y
T
N
S
D
R
T
N
E
Q
N
----
L
Q
S
R
G
T
G
K
R
A
E
A
W
A
T
G
L
K
Y
D
A
N
-----
N
I
Y
L
--
A
T
F
Y
S
E
T
R
K
M
T
P
---
I
-
T
------------------------------
G
G
F
A
N
K
T
Q
N
F
E
A
V
A
Q
Y
Q
F
D
F
G
----
L
R
P
S
L
G
Y
------------
V
L
S
K
G
K
-------
D
I
E
GIGD-
E
----
D
L
V
--
N
--
Y
I
D
V
G
A
T
Y
Y
F
N
----
K
N
-----------------
M
S
A
F
V
D
Y
K
I
N
Q
L
D
S
D
N
K
-------------
L
N
I
N
N
D
D
I
V
A
V
G
M
T
Y
Q
F
21
HHSearch
63.74
15%
-6
- C3 -
3VY8
2
?
X:
[52-355]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
G
S
K
I
G
F
K
G
-
Q
E
D
L
G
N
G
M
K
A
I
W
Q
L
E
Q
K
A
S
-
I
A
G
T
-----
N
S
G
W
G
N
R
Q
S
F
I
G
L
K
-
G
G
F
G
T
V
R
A
G
N
L
N
T
V
L
K
D
S
G
D
-
N
V
N
A
----------
W
E
S
G
S
N
T
E
D
---------
V
----
L
G
L
------
G
T
I
----------
G
R
V
E
S
R
E
I
S
V
R
Y
D
S
P
V
F
----
A
----
G
F
S
G
S
V
Q
Y
V
P
R
D
N
A
N
D
V
D
K
---------
Y
K
H
T
K
S
S
R
E
S
Y
H
A
G
L
K
Y
E
N
A
--
G
--
F
F
G
Q
Y
A
G
SFA
K
Y
A
D
L
N
T
D
A
E
R
-
V
A
V
N
T
A
N
A
H
P
V
K
D
Y
Q
V
H
R
V
V
A
G
Y
D
A
N
-----
D
L
Y
V
SV
A
G
Q
Y
E
A
A
K
N
N
E
V
-
G
S
I
--------------------------------
K
G
K
K
H
E
Q
T
Q
V
A
A
T
A
A
Y
R
F
G
N
-----
V
T
P
R
V
S
Y
------------
A
H
G
F
K
A
KVNGVKD
A
-------
N
----
Y
Q
Y
--
D
--
Q
V
I
V
G
A
D
Y
D
F
S
----
K
R
-----------------
T
S
A
L
V
S
A
G
W
L
K
Q
G
K
G
A
---------------
G
K
V
E
Q
T
A
S
M
V
G
L
R
H
K
F
22
HHSearch
62.88
16%
-3
- C3 -
2J1N
2
OMPC_ECOLI
A:
[32-346]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
T
Y
M
R
L
G
F
K
G
-
E
T
Q
V
T
D
Q
L
T
G
Y
G
Q
W
E
Y
Q
I
Q
G
N
S
A
--
E
--
N
E
N
N
S
W
T
R
V
A
F
A
G
L
K
F
Q
D
V
G
S
F
D
Y
G
R
N
Y
G
V
V
Y
D
V
T
-
S
W
T
D
V
L
P
E
----------
F
G
G
D
-
T
-----------
Y
--
G
S
D
N
F
------------------
M
Q
Q
R
G
N
G
F
A
T
Y
R
N
T
D
F
FGLV
D
----
G
L
N
F
A
V
Q
Y
Q
G
K
N
G
N
P
S
G
E
G
F
T
S
GV
T
N
N
G
R
D
A
L
R
Q
N
G
D
G
V
G
G
S
I
T
Y
D
Y
--
E
G
----
F
G
I
G
G
---
A
I
S
S
S
K
R
T
D
A
Q
N
T
---
A
A
Y
I
G
N
G
D
R
A
E
T
Y
T
G
G
L
K
Y
D
A
N
-----
N
I
Y
L
--
A
A
Q
Y
T
Q
T
Y
N
A
T
R
V
G
S
---------------------------------
L
G
W
A
N
K
A
Q
N
F
E
A
V
A
Q
Y
Q
F
D
F
G
----
L
R
P
S
L
A
Y
------------
L
Q
S
K
G
K
-------
N
LGRGYDD
E
----
D
I
L
--
K
--
Y
V
D
V
G
A
T
Y
Y
F
N
----
K
N
-----------------
M
S
T
Y
V
D
Y
K
I
N
L
L
D
D
N
Q
F
T
R
----------
D
A
G
I
N
T
D
N
I
V
A
L
G
L
V
Y
Q
F
17
HHSearch
58.53
15%
14
- C3 -
2POR
7
PORI_RHOCA
A:
[21-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
S
R
S
R
V
L
F
T
M
-
S
G
T
T
D
S
G
L
E
F
G
A
S
F
K
A
H
E
S
-
V
G
---
A
------
E
T
G
E
D
G
T
V
F
L
S
-
G
A
F
G
K
I
E
M
G
D
A
L
G
A
S
E
A
L
F
G
D
L
Y
E
V
G
Y
T
D
L
---
D
D
R
----
G
G
N
D
----------
I
P
Y
--
L
--
T
----
G
D
-----------
E
R
L
T
A
E
D
N
P
V
L
L
Y
T
Y
S
A
----
G
----
A
F
S
V
A
A
S
M
S
D
G
K
V
G
E
-----------------
T
S
E
D
D
A
Q
E
M
A
V
A
A
A
Y
T
F
G
N
--
Y
T
V
G
--
L
---
G
Y
E
K
I
D
S
P
D
----------
T
A
L
M
A
D
M
E
Q
L
E
L
A
A
I
A
K
F
G
-----
A
T
N
V
--
K
A
Y
Y
A
D
G
E
L
D
R
D
F
A
R
A
V
----------------
F
D
L
-----
T
P
-
V
A
-
A
A
A
T
A
V
D
H
K
A
Y
G
L
S
V
D
S
T
F
G
A
-----
T
T
V
G
G
Y
V
------------
Q
V
L
D
I
D
-------
T
-------
I
----
D
D
V
--
T
--
Y
Y
G
L
G
A
S
Y
D
L
G
----
G
G
-----------------
A
S
I
V
G
G
I
A
D
N
D
L
P
N
--------------------
S
D
M
V
A
D
L
G
V
K
F
K
F
18
HHSearch
55.83
14%
-22
- C3 -
3PRN
4
PORI_RHOBL
A:
[27-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
S
R
L
R
I
N
I
V
G
-
T
T
E
T
D
Q
G
V
T
F
G
A
K
L
R
M
Q
W
D
D
G
D
-
A
F
A
-----
G
T
A
G
N
A
A
Q
F
W
T
S
-
Y
N
G
V
T
V
S
V
G
N
V
D
T
A
F
D
S
V
A
L
T
Y
D
S
E
M
G
-
Y
--
E
W
S
S
F
G
---
D
A
-
Q
S
----
S
F
F
A
Y
N
S
K
-
Y
D
A
----------------
S
G
-
A
L
D
N
Y
N
G
I
A
V
T
Y
---
S
I
----
S
----
G
V
N
L
Y
L
S
Y
V
D
P
D
Q
T
V
D
---------------
S
S
L
V
T
E
E
F
G
I
A
A
D
W
S
N
D
--
M
----
I
S
L
A
A
---
A
Y
T
T
D
A
G
G
I
------------
V
D
N
D
I
A
F
V
G
A
A
Y
K
F
N
D
------
A
G
T
V
--
G
L
N
W
Y
D
N
G
L
------------------------------------------
S
T
A
G
D
Q
V
T
L
Y
G
N
Y
A
F
G
A
-----
T
T
V
R
A
Y
V
------------
S
D
I
D
R
A
--------------------
G
A
D
--
T
--
A
Y
G
I
G
A
D
Y
Q
F
A
----
E
G
-----------------
V
K
V
S
G
S
V
Q
S
G
F
A
N
----------------------
E
T
V
A
D
V
G
V
R
F
D
F
1
PsiBlast_PDB
53.09
26%
28
- C2 -
4YNT
1
?
A:
[224-399]
-----------------------------------------------------------------------------------------------------------
R
K
N
L
H
L
L
--------
E
N
T
T
A
N
R
L
F
W
K
N
G
S
A
E
E
A
I
A
D
G
V
E
I
T
-
S
A
D
G
K
V
T
R
V
H
A
K
K
E
V
-
I
I
S
A
G
A
L
R
----
S
P
L
I
L
E
L
S
G
V
G
N
P
T
I
L
K
K
N
N
I
T
P
R
V
D
L
P
T
V
G
E
-
N
L
Q
D
Q
F
N
N
G
M
A
G
E
G
Y
---
G
V
L
A
G
A
S
T
V
T
Y
P
S
I
S
D
V
F
G
N
E
T
D
S
I
V
A
S
L
R
S
Q
L
S
D
Y
A
A
A
T
V
K
V
S
N
G
--
H
M
K
Q
E
D
L
E
R
L
Y
Q
L
Q
F
D
L
I
V
K
D
K
V
P
I
A
E
I
L
F
H
P
G
G
G
N
A
V
S
S
E
F
W
G
L
L
P
F
-
A
R
G
N
I
H
I
S
S
N
D
P
T
A
P
A
A
I
N
P
N
Y
F
M
F
E
W
D
G
K
S
Q
A
G
I
A
K
Y
I
R
K
I
L
R
S
A
P
L
N
K
L
I
-
A
K
E
T
K
P
G
L
S
E
I
P
A
T
A
A
D
E
K
W
V
E
W
L
K
A
N
Y
R
S
N
F
H
P
V
G
T
A
A
M
M
P
R
S
----
I
----
G
G
V
V
D
N
R
L
R
V
Y
G
T
S
N
V
R
V
V
D
-
A
--
S
V
L
P
F
Q
V
C
G
H
L
V
S
T
L
Y
A
V
A
E
R
A
S
D
L
I
K
E
D
A
K
S
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
53.03
26%
30
- C2 -
4YNU
2
?
A:
[224-399]
-----------------------------------------------------------------------------------------------------------
R
K
N
L
H
L
L
--------
E
N
T
T
A
N
R
L
F
W
K
N
G
S
A
E
E
A
I
A
D
G
V
E
I
T
-
S
A
DG
K
V
T
R
V
H
A
K
K
E
V
-
I
I
S
A
G
A
L
R
----
S
P
L
I
L
E
L
S
G
V
G
N
P
T
I
L
K
K
N
N
I
T
P
R
V
D
L
P
T
V
G
E
-
N
L
Q
D
Q
F
N
N
G
M
A
G
E
G
Y
---
G
V
L
A
G
A
S
T
V
T
Y
P
S
I
S
D
V
F
G
N
E
T
D
S
I
V
A
S
L
R
S
Q
L
S
D
Y
A
A
A
T
V
K
V
S
N
G
--
H
M
K
Q
E
D
L
E
R
L
Y
Q
L
Q
F
D
L
I
V
K
D
K
V
P
I
A
E
I
L
F
H
P
G
G
G
N
A
V
S
S
E
F
W
G
L
L
P
F
-
A
R
G
N
I
H
I
S
S
N
D
P
T
A
P
A
A
I
N
P
N
Y
F
M
F
E
W
D
G
K
S
Q
A
G
I
A
K
Y
I
R
K
I
L
R
S
A
P
L
N
K
L
I
-
A
K
E
T
K
P
G
L
S
E
I
P
A
T
A
A
D
E
K
W
V
E
W
L
K
A
N
Y
R
S
N
F
H
P
V
G
T
A
A
M
M
P
R
S
----
I
----
G
G
V
V
D
N
R
L
R
V
Y
G
T
S
N
V
R
V
V
D
-
A
--
S
V
L
P
F
Q
V
C
G
H
L
V
S
T
L
Y
A
V
A
E
R
A
S
D
L
I
K
E
D
A
K
S
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
52.10
21%
55
- C3 -
1PHO
-
PHOE_ECOLI
A:
[189-340]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
Y
T
N
S
D
R
T
N
E
Q
N
-
L
Q
-
S
R
G
T
G
K
R
A
E
A
W
A
T
G
L
K
Y
D
A
N
N
-----
I
Y
L
A
T
F
Y
S
E
T
R
KMTPITGG
F
A
N
K
T
Q
-------
N
-------
F
----
E
A
V
A
Q
Y
--
Q
F
D
F
G
L
R
P
S
L
G
----
Y
V
L
S
K
G
K
DIEGIGDEDL
V
N
Y
I
D
V
G
A
T
Y
Y
F
N
K
N
M
S
A
F
V
D
Y
K
I
N
Q
L
D
S
D
N
K
L
N
I
N
N
D
D
I
V
A
V
G
M
T
Y
Q
F
6
PsiBlast_PDB
44.21
23%
58
- C2 -
3VKG
-
?
A:
[1922-2031]
---------------------------
L
N
I
G
L
K
K
L
R
--
D
T
E
A
Q
V
K
D
L
Q
V
S
L
A
Q
K
N
R
E
L
D
V
K
N
E
Q
A
N
Q
K
L
K
Q
M
V
Q
---
D
Q
Q
A
A
E
I
K
Q
K
D
A
R
E
L
Q
V
Q
L
D
V
R
N
K
E
I
A
V
Q
K
V
K
--
A
Y
A
--------
D
L
-------
P
L
R
E
E
V
E
Q
L
E
N
A
A
N
E
L
K
-
L
K
--
Q
D
E
I
V
A
T
I
T
A
L
E
K
S
I
A
T
Y
K
E
E
Y
A
T
L
I
R
E
T
----
E
Q
I
K
T
E
S
S
K
V
K
N
K
V
D
R
S
I
A
L
L
D
N
L
N
S
E
R
G
R
W
E
Q
Q
S
E
N
F
N
T
Q
M
S
T
V
V
G
D
V
V
L
A
S
A
F
L
A
Y
I
G
F
F
-
D
Q
N
F
R
T
D
L
M
R
K
W
M
I
R
L
D
S
V
G
I
K
F
K
S
D
L
S
V
P
S
F
L
S
K
P
E
E
R
L
N
W
H
A
N
S
L
P
S
D
E
L
C
I
E
N
A
I
M
L
K
R
F
N
R
Y
P
L
V
I
D
P
S
G
Q
-
A
M
E
F
L
M
N
Q
Y
A
D
K
K
I
T
K
T
S
F
M
K
N
L
E
S
A
L
R
F
G
C
P
L
L
V
Q
D
V
E
S
F
M
I
F
L
F
T
R
D
P
T
A
-
H
F
T
P
D
L
C
S
R
V
T
F
V
N
F
T
V
T
P
S
S
L
Q
S
Q
C
L
H
E
A
L
K
T
E
R
P
D
T
H
K
K
R
S
D
----
L
----
L
K
I
Q
G
E
F
Q
V
K
L
R
I
L
E
K
S
L
L
N
-
A
--
L
S
Q
A
S
G
N
I
L
D
D
D
S
V
I
S
T
L
E
T
L
K
K
E
T
T
E
I
A
L
K
V
E
E
T
E
---
T
V
M
Q
E
I
S
E
V
S
A
L
Y
N
P
M
A
L
S
C
S
R
V
Y
F
A
M
E
E
L
S
Q
F
H
L
Y
Q
F
S
L
R
A
F
L
D
I
F
--
Y
N
L
L
N
N
N
P
N
L
V
D
K
K
D
P
N
E
R
L
V
Y
L
S
K
D
I
F
S
M
T
F
N
R
V
T
R
T
L
L
N
D
D
-
K
L
-
T
F
A
L
Q
L
T
I
I
S
V
K
G
T
S
N
E
I
E
E
S
-----
E
W
D
F
L
L
K
------------
G
G
D
N
L
T
-------
S
-------
I
----
K
E
T
--
I
--
P
Q
L
D
S
L
L
S
T
T
Q
----
Q
K
W
L
I
C
L
------------
R
Q
Q
V
P
S
F
S
K
L
V
D
H
I
Q
Q
N
S
S
D
W
K
Q
F
F
G
K
D
Q
V
G
E
P
I
I
P
E
S
W
I
V
A
Q
A
Q
L
S
7
PsiBlast_PDB
42.27
22%
132
- C2 -
3VKH
-
DYHC_DICDI
A:
[1916-1983]
-------------------------------------------------------------------------------------
E
E
E
--
Q
L
H
L
N
I
G
L
K
K
L
R
D
T
E
A
Q
V
K
D
L
Q
V
S
--------
L
A
Q
K
N
R
E
L
D
V
K
N
E
Q
A
N
Q
K
L
K
Q
M
V
Q
D
Q
-
Q
A
--
A
E
I
K
Q
K
D
A
R
E
L
Q
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
41.71
12%
10
- C3 -
3T24
5
?
A:
[216-382]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
Y
K
Q
H
Y
L
G
L
V
H
T
L
P
I
A
D
-
K
Q
S
L
K
S
D
I
---
R
--
W
A
R
S
T
D
D
G
---------
S
S
N
V
D
N
K
A
L
N
A
M
F
T
Y
S
L
G
-----
Y
H
A
F
--
G
V
G
Y
Q
K
M
S
G
D
T
G
F
A
Y
I
N
G
--
A
D
P
Y
----------------
L
V
N
F
I
Q
I
G
D
F
A
N
K
D
E
K
S
W
Q
A
R
Y
D
Y
N
F
A
G
VGIPG
L
T
F
M
T
R
Y
------------
V
K
G
D
N
I
-------
D
-------
L
LT
T
S
G
E
G
--
K
E
W
E
R
D
M
D
I
A
Y
V
F
Q
SGPL
K
N
-----------------
L
G
V
K
W
R
N
A
T
M
R
T
N
Y
T
N
D
Y
D
E
N
R
L
I
V
S
Y
T
L
P
L
W
---------------
44
Fugue
38.86
15%
88
- C2 -
2WT7
3
B:
[1-90]
------------------------------------------------------
D
Q
L
V
S
M
S
V
R
E
L
N
R
H
L
R
G
F
------
T
K
D
E
V
I
R
L
K
Q
--
K
R
R
T
L
K
N
R
G
Y
A
Q
S
C
R
Y
K
R
V
Q
Q
K
H
H
--------
L
E
N
E
K
T
Q
L
I
Q
Q
V
E
Q
L
K
Q
E
V
S
R
L
A
R
E
R
-
D
A
--
Y
K
V
K
S
E
K
L
A
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
36.91
21%
93
- C1 -
3OQQ
3
?
A:
[227-369]
---------------------------------------------------------------------------------
E
E
L
S
T
K
N
--
I
V
K
V
--
E
N
K
N
W
N
W
S
N
D
T
R
K
E
P
R
F
A
I
L
T
V
D
KAQ
A
E
G
T
V
I
T
L
D
G
L
T
S
L
M
D
N
N
Q
D
M
F
Q
V
T
Q
G
K
V
--
R
E
G
L
P
M
L
R
A
E
V
R
L
I
G
K
E
G
L
T
G
A
E
R
D
A
Q
L
A
----
A
F
R
E
L
I
L
D
T
N
R
Q
N
F
F
I
K
V
N
G
G
K
E
I
H
M
R
G
Y
A
P
T
S
A
Y
K
A
E
Y
E
--
A
L
V
A
G
D
T
T
L
D
A
N
V
Y
Y
S
N
T
K
G
-
S
T
W
G
V
K
L
P
V
G
T
R
H
A
Y
E
R
V
P
F
R
E
A
Y
P
D
F
T
K
W
V
D
S
K
G
V
S
N
Q
K
W
Y
E
N
F
V
D
E
K
T
I
R
Y
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
36.29
12%
111
* C2 *
1SFC
2
STX1A_RAT
B:
[9-80]
----------------------------------------------------------------------------
S
K
Q
A
L
S
E
I
E
T
R
H
--
S
E
I
I
K
L
E
N
S
I
R
E
L
H
D
M
F
M
D
M
A
M
L
V
--------
E
S
Q
G
E
M
-
I
D
R
I
E
Y
N
V
E
H
A
V
D
Y
V
E
R
A
V
-
S
D
--
T
K
K
A
V
K
Y
Q
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
35.34
11%
-12
- C3 -
3PRN
-
PORI_RHOBL
A:
[131-247]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
G
I
A
V
T
Y
S
I
S
G
--
V
N
L
Y
L
S
Y
-----
V
D
P
D
Q
T
V
D
-----------
S
S
L
V
T
E
E
F
G
I
A
A
D
W
S
N
D
-----
M
I
S
L
--
A
A
A
Y
T
T
D
A
G
G
-----------------------------------------
I
V
D
N
D
I
A
F
V
G
A
A
Y
K
F
N
D
A----
G
T
V
G
L
N
W
------------
Y
D
N
G
L
----------------
S
----
T
A
G
--
D
--
Q
V
T
L
Y
G
N
Y
A
F
G
----
A
------------------
T
T
V
R
A
Y
V
S
D
I
D
R
A
G
A
D
T
A
Y
G
I
G
A
D
Y
Q
F
A
E
G
V
K
V
S
G
S
V
Q
S
G
F
A
N
E
T
V
A
3
PsiBlast_PDB
34.58
33%
58
- C2 -
4FYE
-
?
A:
[266-342]
------------------
S
F
S
G
P
G
A
R
M
P
Y
S
D
F
K
G
A
D
D
Y
K
K
L
-
A
I
K
A
V
T
L
I
--
N
Q
E
E
V
I
Q
T
L
A
Q
R
---
Q
I
D
R
M
T
N
E
D
L
W
N
K
I
P
E
E
Y
R
P
D
--
E
L
P
P
D
A
E
K
A
R
A
Q
L
I
K
L
Y
V
E
H
N
P
L
S
--------
V
T
E
C
Y
T
Q
V
V
T
A
G
Q
R
V
A
A
E
N
Q
K
E
Q
F
E
Y
-
V
R
--
Q
M
M
D
A
F
D
G
S
K
A
K
I
T
I
Q
T
G
S
N
T
E
V
E
T
A
V
G
Y
----
Q
A
R
M
S
S
W
G
V
N
W
F
R
Q
V
G
A
L
N
P
L
S
D
N
S
V
T
K
N
Q
N
A
R
F
V
N
Q
M
T
D
D
V
I
R
N
L
D
K
V
A
Q
N
L
G
D
Y
D
K
A
G
A
L
-
H
T
L
L
K
G
P
D
V
S
D
L
N
Q
Q
I
T
E
K
E
N
A
L
K
E
V
K
G
A
Y
R
E
A
L
F
S
Y
F
E
E
Y
Q
K
G
E
G
K
W
D
Q
A
K
L
D
Q
L
K
N
Q
V
D
G
Y
E
K
S
I
K
K
Q
E
S
A
I
Y
-
E
L
H
N
Q
I
D
A
L
R
K
A
Y
Y
T
E
H
K
G
Q
I
N
K
A
L
Q
E
L
K
E
Q
I
S
P
V
I
Q
N
K
E
T
D
P
E
T
K
S
R
L
Q
H
F
-
Y
N
S
C
A
Y
L
T
Q
A
Q
E
L
Y
Y
E
N
T
W
H
H
G
K
N
N
F
K
L
Q
T
L
M
A
S
L
S
C
E
L
D
Y
A
N
T
----
K
----
G
S
K
S
N
N
D
R
G
Q
R
L
A
Q
K
I
V
G
N
A
-
L
--
W
T
A
M
S
E
D
G
L
Y
T
G
E
F
L
D
H
R
R
T
H
G
K
E
V
S
N
V
E
Q
L
D
R
E
L
T
---
T
I
Q
A
L
H
H
T
A
N
T
G
V
S
G
G
K
F
E
I
Q
D
K
A
N
F
A
D
N
G
L
F
G
K
V
A
N
F
A
K
I
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------