@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0012: (2015-11-27 )
MNYYKTHTCNELRKNDVEKEVTLSGWMYRKRDHGNLIFVDLRDFYGITQLVFNNDKDFFCKISDLKPESVITVTGIVKARTEDTINISISTGEIEVTVNNLQIESEVEFHHNEETAKEERSILASIADDQEYPENMRFKYRFLDLRREKVRNNIVLRSQIIAELRKFMIEQGFLEIQTPILTASSPEGARDYLVPSRLNPGKFYALPQAPQIFKQLLMISGFDKYFQIAPCFRDEDARADRSPGEFYQLDLEMSFVTQEDVFQVIESTLYKVFAKFSRKSVDKGFSRITYKEAMLKYGSDKPDLRNPLLISDVTEIFRDSEFNIFKSNIERGMVVRAIPAPKTAEEPRSFFDKKIEHTQKEFGAKGLGYITFNKDGTAKGPIAKFLDDNRLNHIREATNIKPGDSVFFASDKENEAATIAGKVRTLLGSELGLIDNNIFKFCWVVDFPYFVYDDKSKKIDFFHNPFSMPHGGLKDLEEKNPLDILAYQYDLVCNGIELSSGAIRNNKLDIMYKAFATAGYNKEEVNKKFGALVRAFRFGVPPHGGIAPGIDRIVMLLADAPNIREITCFPMNQQGEDVLMDAPSKVDNKHLRELSLKVVE
Atome Classification :
(20 SA)
.........10........20........30........40........50.-...------.---...60.-.......70........80........90........100.....-.---.110.......120......------.130.......140.......150.......160.......170........180.......190.......200.......210.......220.......230.......240.......250....-...260.......270.......280-----------....-.....290.......300.......310.......320....--...330..-......340.......350.......360.......----370....----...380----.....-....390.......400.......410.......420.......430--...--.....440.......450....----------....460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNYYKTH
T
C
N
E
L
R
K
NDVEK
E
V
TLS
G
W
M
Y
R
KRDHG
N
L
I
F
V
D
L
R
D
FY
G
I
T
Q
L
VF-NND------K---
D
F
F
C
K
I-SDLKPE
S
V
I
T
V
T
G
I
V
KARTE
D
T
I
N
I
S
I
ST
G
E
I
E
V
T
V
N
N
L
Q
I
E
S
E
V
-
E
---
F
HHNE
E
T
A
K
E
E
R
S
I
L
A
S
IAD------DQEYPEN
M
R
F
K
Y
R
F
L
D
L
R
R
E
K
V
RNNI
V
L
R
S
Q
I
I
A
E
L
R
K
F
M
I
E-QGF
L
E
I
QT
P
I
L
TASSPEGARDYLVPSRLNPG
K
F
YALPQ
A
P
Q
I
F
K
Q
L
L
M
ISG
F
D
K
Y
F
Q
IAPCFRDEDARADRSPG
E
F
Y
Q
L
D
L
E
M
SFV-
T
Q
E
D
V
F
Q
V
I
E
S
T
L
Y
K
V
F
A
K
F
S
R
K
S
-------------
V
D
K
G
-
F
S
R
I
T
Y
K
E
A
M
L
KYGSDKPDLRNP
L
L
I
S
D
V
T
E
I
F
RDSEF
N
I
F
K
--
S
NIE-R
G
M
-
V
V
R
AIPAPKT
A
E
E
P
R
S
F
F
D
K
K
I
E
H
T
Q
K
E
FGAK
G
L
G
Y
----
I
T
FNKDG----TAKG------
P
I
A
K
F
-LDDN
R
L
N
H
I
R
E
ATNIKPGD
S
V
F
F
ASDKENE
A
A
T
I
A
G
K
V
R
T
L
L
G
S
EL---GLI--DNN
I
F
K
F
C
W
V
VDF
P
Y
F
V
-YDDK----------S
K
K
I
D
FFHNPFSMPHG
G
L
K
D
LEEKNP
L
D
I
L
A
Y
Q
Y
D
L
V
CN
G
I
ELSSGAIRNN
K
L
D
I
M
Y
K
A
F
ATAGY
N
K
E
E
V
N
K
K
F
G
A
L
V
R
A
F
RFGVPPHGGIAP
G
I
D
R
I
V
M
L
LADAPN
I
R
E
I
T
C
F
PMNQQGED
V
L
MDAPSKV
D
N
K
H
L
R
E
L
S
L
K
VVE
7
PsiBlast_PDB
93.32
40%
-83
- C4 -
4WJ4
1
SYDND_PSEAE
A:
[11-594]
----
R
S
H
Y
C
G
Q
L
N
E
S
L
D
G
Q
E
V
T
L
C
G
W
V
H
R
R
R
D
H
G
G
V
I
F
L
D
V
R
D
R
E
G
L
A
Q
V
V
F
-
D
P
D
------
R
A
--
E
T
F
A
K
A
-
D
R
V
R
S
E
F
V
V
K
I
T
G
K
V
R
L
R
P
E
G
A
R
N
P
N
M
A
S
G
S
I
E
V
L
G
Y
E
L
E
V
L
N
Q
A
-
E
TPP
F
P
L
D
E
Y
S
---------------------
D
V
G
E
E
T
R
L
R
Y
R
F
I
D
L
R
R
P
E
M
A
A
K
L
K
L
R
A
R
I
T
S
S
I
R
R
Y
L
D
D
-
N
G
F
L
D
V
E
T
P
I
L
G
R
P
T
P
E
G
A
R
D
Y
L
V
P
S
R
T
Y
P
G
H
F
F
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
V
A
G
F
D
R
Y
Y
Q
I
A
K
C
F
R
D
E
D
L
R
A
D
R
Q
P
-
E
F
T
Q
I
D
I
E
T
S
F
L
-
D
E
S
D
I
I
G
I
T
E
K
M
V
R
Q
L
F
K
E
V
L
D
V
E
-------------
F
D
E
--
F
P
H
M
P
F
E
E
A
M
R
R
Y
G
S
D
K
P
D
L
R
I
P
L
E
L
V
D
V
A
D
Q
L
K
E
V
E
F
K
V
F
S
G
P
A
N
D
P
-
K
G
R
-
V
A
-
A
L
R
V
P
G
A
A
S
M
P
R
S
Q
I
D
D
Y
T
K
F
V
G
I
-
Y
G
A
K
G
L
A
Y
----
I
K
V
N
E
------
R
A
K
G
VEGLQS
P
I
V
K
F
-
I
P
E
A
N
L
N
V
I
L
D
R
V
G
A
V
D
G
D
I
V
F
F
G
A
D
K
A
K
I
V
C
D
A
L
G
A
L
R
I
K
V
G
H
D
L
---
K
L
L
--
T
R
E
-
W
A
P
M
W
V
V
D
F
P
M
F
E
-
E
N
D
D
----------
G
-
S
L
S
A
L
H
H
P
F
T
S
P
K
C
T
P
A
E
L
-
E
A
N
P
G
A
A
L
S
R
A
Y
D
M
V
L
N
G
T
E
L
G
G
G
S
I
R
I
H
D
K
S
M
Q
Q
A
V
F
R
V
L
G
I
D
E
A
E
Q
E
E
K
F
G
F
L
L
D
A
L
K
Y
G
A
P
P
H
G
G
L
A
F
G
L
D
R
L
V
M
L
M
T
G
A
S
S
I
R
E
V
I
A
F
P
K
T
Q
S
A
G
D
V
M
T
Q
A
P
G
S
V
D
G
K
A
L
R
E
L
H
I
R
L
R
E
6
PsiBlast_PDB
92.96
40%
-84
- C4 -
4WJ3
-
SYDND_PSEAE
M:
[11-594]
----
R
S
H
Y
C
G
Q
L
N
E
S
L
D
G
Q
E
V
T
L
C
G
W
V
H
R
R
R
D
H
G
G
V
I
F
L
D
V
R
D
R
E
G
L
A
Q
V
V
F
-
D
P
D
------
R
A--
E
T
F
A
K
A
-
D
R
V
R
S
E
F
V
V
K
I
T
G
K
V
R
L
R
P
E
G
A
R
N
P
N
M
A
S
G
S
I
E
V
L
G
Y
E
L
E
V
L
N
Q
A
-
E
TPP
F
P
L
D
E
Y
S
---------------------
D
V
G
E
E
T
R
L
R
Y
R
F
I
D
L
R
R
P
E
M
A
A
K
L
K
L
R
A
R
I
T
S
S
I
R
R
Y
L
D
D
-
N
G
F
L
D
V
E
T
P
I
L
G
R
P
T
P
E
G
A
R
D
Y
L
V
P
S
R
T
Y
P
G
H
F
F
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
V
A
G
F
D
R
Y
Y
Q
I
A
K
C
F
R
D
E
D
L
R
A
D
R
Q
P
-
E
F
T
Q
I
D
I
E
T
S
F
L
-
D
E
S
D
I
I
G
I
T
E
K
M
V
R
Q
L
F
K
E
V
L
D
V
E
-------------
F
D
E
--
F
P
H
M
P
F
E
E
A
M
R
R
Y
G
S
D
K
P
D
L
R
I
P
L
E
L
V
D
V
A
D
Q
L
K
E
V
E
F
K
V
F
S
GP
A
N
D
P
-
K
G
R
-
V
A
-
A
L
R
V
P
G
A
A
S
M
P
R
S
Q
I
D
D
Y
T
K
F
V
G
I
-
Y
G
A
K
G
L
A
Y
----
I
K
V
N
E
------
R
A
K
G
VEGLQS
P
I
V
K
F
-
I
P
E
A
N
L
N
V
I
L
D
R
V
G
A
V
D
G
D
I
V
F
F
G
A
D
K
A
K
I
V
C
D
A
L
G
A
L
R
I
K
V
G
H
D
L
---
K
L
L
--
T
R
E
-
W
A
P
M
W
V
V
D
F
P
M
F
E
-
E
N
D
D
----------
G
-
S
L
S
A
L
H
H
P
F
T
S
P
K
C
T
P
A
E
L
-
E
A
N
P
G
A
A
L
S
R
A
Y
D
M
V
L
N
G
T
E
L
G
G
G
S
I
R
I
H
D
K
S
M
Q
Q
A
V
F
R
V
L
G
I
D
E
A
E
Q
E
E
K
F
G
F
L
L
D
A
L
K
Y
G
A
P
P
H
G
G
L
A
F
G
L
D
R
L
V
M
L
M
T
G
A
S
S
I
R
E
V
I
A
F
P
K
T
Q
S
A
G
D
V
M
T
Q
A
P
G
S
V
D
G
K
A
L
R
E
L
H
I
R
L
R
E
26
HHSearch
92.68
42%
-81
- C4 -
1L0W
-
SYD_THETH
A:
[1-579]
--
M
R
R
T
H
Y
A
G
S
L
R
E
T
H
V
G
E
E
V
V
L
E
G
W
V
N
R
R
R
D
L
G
G
L
I
F
L
D
L
R
D
R
E
G
L
V
Q
L
V
A
-
H
P
A
------
S
---
P
A
Y
A
T
A
-
E
R
V
R
P
E
W
V
V
R
A
K
G
L
V
R
L
R
P
E
--
P
N
P
R
L
A
T
G
R
V
E
V
E
L
S
A
L
E
V
L
A
E
A
-
K
---------------
T
P
P
F
P
V
D
A
GWRG
E
E
E
K
E
A
S
E
E
L
R
L
K
Y
R
Y
L
D
L
R
R
R
R
M
Q
E
N
L
R
L
R
H
R
V
I
K
A
I
W
D
F
L
D
R
-
E
G
F
V
Q
V
E
T
P
F
L
T
K
S
T
P
E
G
A
R
D
F
L
V
P
Y
R
H
E
P
G
L
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
M
L
M
V
A
G
L
D
R
Y
F
Q
I
A
R
C
F
R
D
E
D
L
R
A
D
R
Q
P
-
D
F
T
Q
L
D
L
E
M
S
F
V
-
E
V
E
D
V
L
E
L
N
E
R
L
M
A
H
V
F
R
E
A
L
G
V
E
-------------
L
P
L
P
-
F
P
R
L
S
Y
E
E
A
M
E
R
Y
G
S
D
K
P
D
L
R
F
G
L
E
L
K
E
V
G
P
L
F
R
Q
S
G
F
R
V
F
Q
--
E
-----
A
E
-
S
V
K
A
L
A
L
P
K
--
A
L
S
R
K
E
V
A
E
L
E
E
V
A
K
R
H
-
K
A
Q
G
L
A
W
----
A
R
V
E
E
G
-----
G
F
S
G
------
G
V
A
K
F
-
L
E
-
P
V
R
E
A
L
L
Q
A
T
E
A
R
P
G
D
T
L
L
F
V
A
G
P
R
K
V
A
A
T
A
L
G
A
V
R
L
R
A
A
D
L
L
---
G
L
K
---
R
E
G
F
R
F
L
W
V
V
D
F
P
L
L
E
-
W
D
E
E
----------
E
E
A
W
T
Y
M
H
H
P
F
T
S
P
H
P
E
D
L
P
L
L
E
K
D
P
G
R
V
R
A
L
A
Y
D
L
V
L
N
G
V
E
V
G
G
G
S
I
R
I
H
D
P
R
L
Q
A
R
V
F
R
L
L
G
I
G
E
E
E
Q
R
E
K
F
G
F
F
L
E
A
L
E
Y
G
A
P
P
H
G
G
I
A
W
G
L
D
R
L
L
A
L
M
T
G
S
P
S
I
R
E
V
I
A
F
P
K
N
K
E
G
K
D
P
L
T
G
A
P
S
P
V
P
E
E
Q
L
R
E
L
G
L
M
V
V
R
24
PsiBlast_CBE
92.16
41%
-83
- C4 -
1EQR
1
SYD_ECOLI
B:
[2-585]
----
R
T
E
Y
C
G
Q
L
R
L
S
H
V
G
Q
Q
V
T
L
C
G
W
V
N
R
R
R
D
L
G
S
L
I
F
I
D
M
R
D
R
E
G
I
V
Q
V
F
F
-
D
P
D
------
R
---
A
D
A
L
K
L
A
S
E
L
R
N
E
F
C
I
Q
V
T
G
T
V
R
A
R
D
E
K
N
I
N
R
D
M
A
T
G
E
I
E
V
L
A
S
S
L
T
I
I
N
------------------
R
A
D
V
L
P
L
D
S
------
N
H
V
N
T
E
E
A
R
L
K
Y
R
Y
L
D
L
R
R
P
E
M
A
Q
R
L
K
T
R
A
K
I
T
S
L
V
R
R
F
M
D
D
-
H
G
F
L
D
I
E
T
P
M
L
T
K
A
T
P
E
G
A
R
D
Y
L
V
P
S
R
V
H
K
G
K
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
M
S
G
F
D
R
Y
Y
Q
I
V
K
C
F
R
D
E
D
L
R
A
D
R
Q
P
-
E
F
T
Q
I
D
V
E
T
S
F
M
-
T
A
P
Q
V
R
E
V
M
E
A
L
V
R
H
L
W
L
E
V
--
K
G
-------------
V
D
L
G
D
F
P
V
M
T
F
A
E
A
E
R
R
Y
G
S
D
K
P
D
L
R
N
P
M
E
L
T
D
V
A
D
L
L
K
S
V
E
F
A
V
F
A
GP
A
N
D
P
-
K
G
R
-
V
A
-
A
L
R
V
P
G
G
A
S
L
T
R
K
Q
I
D
E
Y
G
N
F
V
-
K
I
Y
G
A
K
G
L
A
Y
----
I
K
V
N
E
------
R
A
K
G
LEGINS
P
V
A
K
F
-
L
N
A
E
I
I
E
D
I
L
D
R
T
A
A
Q
D
G
D
M
I
F
F
G
A
D
N
K
K
I
V
A
D
A
M
G
A
L
R
L
K
V
G
K
D
L
---
G
L
T
--
D
E
S
K
W
A
P
L
W
V
I
D
F
P
M
F
--
E
D
D
G
----------
E
G
G
L
T
A
M
H
H
P
F
T
S
P
K
D
M
T
A
A
E
L
K
A
A
P
E
N
A
V
A
N
A
Y
D
M
V
I
N
G
Y
E
V
G
G
G
S
V
R
I
H
N
G
D
M
Q
Q
T
V
F
G
I
L
G
I
N
E
E
E
Q
R
E
K
F
G
F
L
L
D
A
L
K
Y
G
T
P
P
H
A
G
L
A
F
G
L
D
R
L
T
M
L
L
T
G
T
D
N
I
R
D
V
I
A
F
P
K
T
T
A
A
A
C
L
M
T
E
A
P
S
F
A
N
P
T
A
L
A
E
L
S
I
Q
V
V
K
46
Fugue
91.96
41%
-79
- C4 -
1C0A
2
SYD_ECOLI
A:
[1-585]
---
M
R
T
E
Y
C
G
Q
L
R
L
S
H
V
G
Q
Q
V
T
L
C
G
W
V
N
R
R
R
D
L
G
S
L
I
F
I
D
M
R
D
R
E
G
I
V
Q
V
F
F
D
P
D
R
------
A
---
D
A
L
K
L
A
-
S
E
L
R
N
E
F
C
I
Q
V
T
G
T
V
R
A
R
D
E
K
N
I
N
R
D
M
A
T
G
E
I
E
V
L
A
S
S
L
T
I
I
N
R
A
-
D
-----------------
V
L
P
L
D
S
------
N
H
V
N
T
E
E
A
R
L
K
Y
R
Y
L
D
L
R
R
P
E
M
A
Q
R
L
K
T
R
A
K
I
T
S
L
V
R
R
F
M
D
D
-
H
G
F
L
D
I
E
T
P
M
L
T
K
A
T
P
E
G
A
R
D
Y
L
V
P
S
R
V
H
K
G
K
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
M
S
G
F
D
R
Y
Y
Q
I
V
K
C
F
R
D
E
D
L
R
A
D
R
Q
P
-
E
F
T
Q
I
D
V
E
T
S
F
M
-
T
A
P
Q
V
R
E
V
M
E
A
L
V
R
H
L
W
L
E
V
K
G
V
D
-------------
L
G
D
--
F
P
V
M
T
F
A
E
A
E
R
R
Y
G
S
D
K
P
D
L
R
N
P
M
E
L
T
D
V
A
D
L
L
K
S
V
E
F
A
V
F
A
--
G
P
A
N
D
P
K
G
-
R
V
A
A
L
R
V
P
G
G
A
S
L
T
R
K
Q
I
D
E
Y
G
N
F
V
K
I
-
Y
G
A
K
G
L
A
Y
----
I
K
V
N
E
R
A
KGLE
G
I
N
S
------
P
V
A
K
F
-
L
N
A
E
I
I
E
D
I
L
D
R
T
A
A
Q
D
G
D
M
I
F
F
G
A
D
N
K
K
I
V
A
D
A
M
G
A
L
R
L
K
V
G
K
D
L
---
G
L
T
--
D
E
S
K
W
A
P
L
W
V
I
D
F
P
M
F
E
-
D
D
G
E
-----------
G
G
L
T
A
M
H
H
P
F
T
S
P
K
D
M
T
A
A
E
L
K
A
A
P
E
N
A
V
A
N
A
Y
D
M
V
I
N
G
Y
E
V
G
G
G
S
V
R
I
H
N
G
D
M
Q
Q
T
V
F
G
I
L
G
I
N
E
E
E
Q
R
E
K
F
G
F
L
L
D
A
L
K
Y
G
T
P
P
H
A
G
L
A
F
G
L
D
R
L
T
M
L
L
T
G
T
D
N
I
R
D
V
I
A
F
P
K
T
T
A
A
A
C
L
M
T
E
A
P
S
F
A
N
P
T
A
L
A
E
L
S
I
Q
V
V
K
5
PsiBlast_PDB
91.94
41%
-80
- C4 -
1IL2
2
SYD_ECOLI
A:
[2-585]
----
R
T
E
Y
C
G
Q
L
R
L
S
H
V
G
Q
Q
V
T
L
C
G
W
V
N
R
R
R
D
L
G
S
L
I
F
I
D
M
R
D
R
E
G
I
V
Q
V
F
F
-
D
P
D
------
R
---
A
D
A
L
K
L
A
S
E
L
R
N
E
F
C
I
Q
V
T
G
T
V
R
A
R
D
E
K
N
I
N
R
D
M
A
T
G
E
I
E
V
L
A
S
S
L
T
I
I
N
------------------
R
A
D
V
L
P
L
D
S
------
N
H
V
N
T
E
E
A
R
L
K
Y
R
Y
L
D
L
R
R
P
E
M
A
Q
R
L
K
T
R
A
K
I
T
S
L
V
R
R
F
M
D
D
-
H
G
F
L
D
I
E
T
P
M
L
T
K
A
T
P
E
G
A
R
D
Y
L
V
P
S
R
V
H
K
G
K
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
M
S
G
F
D
R
Y
Y
Q
I
V
K
C
F
R
D
E
D
L
R
A
D
R
Q
P
-
E
F
T
Q
I
D
V
E
T
S
F
M
-
T
A
P
Q
V
R
E
V
M
E
A
L
V
R
H
L
W
L
E
V
--
K
G
-------------
V
D
L
G
D
F
P
V
M
T
F
A
E
A
E
R
R
Y
G
S
D
K
P
D
L
R
N
P
M
E
L
T
D
V
A
D
L
L
K
S
V
E
F
A
V
F
A
G
P
A
N
D
P
-
K
G
R
-
V
A
-
A
L
R
V
P
G
G
A
S
L
T
R
K
Q
I
D
E
Y
G
N
F
V
-
K
I
Y
G
A
K
G
L
A
Y
----
I
K
V
N
E
------
R
A
K
G
LEGINS
P
V
A
K
F
-
L
N
A
E
I
I
E
D
I
L
D
R
T
A
A
Q
D
G
D
M
I
F
F
G
A
D
N
K
K
I
V
A
D
A
M
G
A
L
R
L
K
V
G
K
D
L
---
G
L
T
--
D
E
S
K
W
A
P
L
W
V
I
D
F
P
M
F
--
E
D
D
G
----------
E
G
G
L
T
A
M
H
H
P
F
T
S
P
K
D
M
T
A
A
E
L
K
A
A
P
E
N
A
V
A
N
A
Y
D
M
V
I
N
G
Y
E
V
G
G
G
S
V
R
I
H
N
G
D
M
Q
Q
T
V
F
G
I
L
G
I
N
E
E
E
Q
R
E
K
F
G
F
L
L
D
A
L
K
Y
G
T
P
P
H
A
G
L
A
F
G
L
D
R
L
T
M
L
L
T
G
T
D
N
I
R
D
V
I
A
F
P
K
T
T
A
A
A
C
L
M
T
E
A
P
S
F
A
N
P
T
A
L
A
E
L
S
I
Q
V
V
K
22
PsiBlast_CBE
91.93
41%
-79
- C4 -
1IL2
2
SYD_ECOLI
B:
[2-585]
----
R
T
E
Y
C
G
Q
L
R
L
S
H
V
G
Q
Q
V
T
L
C
G
W
V
N
R
R
R
D
L
G
S
L
I
F
I
D
M
R
D
R
E
G
I
V
Q
V
F
F
-
D
P
D
------
R
---
A
D
A
L
K
L
A
S
E
L
R
N
E
F
C
I
Q
V
T
G
T
V
R
A
R
D
E
K
N
I
N
R
D
M
A
T
G
E
I
E
V
L
A
S
S
L
T
I
I
N
------------------
R
A
D
V
L
P
L
D
S
------
N
H
V
N
T
E
E
A
R
L
K
Y
R
Y
L
D
L
R
R
P
E
M
A
Q
R
L
K
T
R
A
K
I
T
S
L
V
R
R
F
M
D
D
-
H
G
F
L
D
I
E
T
P
M
L
T
K
A
T
P
E
G
A
R
D
Y
L
V
P
S
R
V
H
K
G
K
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
M
S
G
F
D
R
Y
Y
Q
I
V
K
C
F
R
D
E
D
L
R
A
D
R
Q
P
-
E
F
T
Q
I
D
V
E
T
S
F
M
-
T
A
P
Q
V
R
E
V
M
E
A
L
V
R
H
L
W
L
E
V
--
K
G
-------------
V
D
L
G
D
F
P
V
M
T
F
A
E
A
E
R
R
Y
G
S
D
K
P
D
L
R
N
P
M
E
L
T
D
V
A
D
L
L
K
S
V
E
F
A
V
F
A
GP
A
N
D
P
-
K
G
R
-
V
A
-
A
L
R
V
P
G
G
A
S
L
T
R
K
Q
I
D
E
Y
G
N
F
V
-
K
I
Y
G
A
K
G
L
A
Y
----
I
K
V
N
E
------
R
A
K
G
LEGINS
P
V
A
K
F
-
L
N
A
E
I
I
E
D
I
L
D
R
T
A
A
Q
D
G
D
M
I
F
F
G
A
D
N
K
K
I
V
A
D
A
M
G
A
L
R
L
K
V
G
K
D
L
---
G
L
T
--
D
E
S
K
W
A
P
L
W
V
I
D
F
P
M
F
--
E
D
D
G
----------
E
G
G
L
T
A
M
H
H
P
F
T
S
P
K
D
M
T
A
A
E
L
K
A
A
P
E
N
A
V
A
N
A
Y
D
M
V
I
N
G
Y
E
V
G
G
G
S
V
R
I
H
N
G
D
M
Q
Q
T
V
F
G
I
L
G
I
N
E
E
E
Q
R
E
K
F
G
F
L
L
D
A
L
K
Y
G
T
P
P
H
A
G
L
A
F
G
L
D
R
L
T
M
L
L
T
G
T
D
N
I
R
D
V
I
A
F
P
K
T
T
A
A
A
C
L
M
T
E
A
P
S
F
A
N
P
T
A
L
A
E
L
S
I
Q
V
V
K
2
PsiBlast_PDB
91.83
41%
-80
- C4 -
4RMF
2
SYDND_MYCS2
A:
[3-580]
----
R
T
H
A
A
G
S
L
R
P
A
D
A
G
Q
T
V
T
L
A
G
W
V
A
R
R
R
D
H
G
G
V
I
F
I
D
L
R
D
A
S
G
V
S
Q
V
V
F
-
R
-
E
------
G
---
D
V
L
A
A
A
-
H
R
L
R
A
E
F
C
V
A
V
T
G
V
V
E
V
R
P
E
G
N
E
N
P
E
I
P
T
G
Q
I
E
V
N
A
T
E
L
T
V
L
G
E
------------------
S
A
P
L
P
F
Q
L
------
D
E
Q
A
G
E
E
A
R
L
K
Y
R
Y
L
D
L
R
R
E
G
P
G
N
A
L
R
L
R
S
K
V
N
A
A
A
R
S
V
L
A
E
-
H
D
F
V
E
I
E
T
P
T
L
T
R
S
T
P
E
G
A
R
D
F
L
V
P
A
R
L
Q
P
G
S
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
V
A
G
M
E
R
Y
Y
Q
I
A
R
C
Y
R
D
E
D
F
R
A
D
R
Q
P
-
E
F
T
Q
L
D
M
E
M
S
F
V
-
E
A
D
D
V
I
A
I
S
E
Q
V
L
K
A
V
W
A
T
I
G
-
Y
D
-------------
L
P
L
P
-
L
P
R
I
S
Y
E
E
A
M
R
R
F
G
S
D
K
P
D
L
R
F
G
I
E
L
V
E
C
T
E
Y
F
K
D
T
T
F
R
V
F
Q
--
A
P
Y
-------
V
G
A
V
V
M
P
G
G
A
S
Q
P
R
R
T
L
D
G
W
Q
E
F
A
-
K
Q
R
G
H
K
G
L
A
Y
----
V
L
V
G
E
D
G
----
T
L
G
G
------
P
V
A
K
N
-
L
S
D
A
E
R
D
G
L
V
A
H
V
G
A
N
P
G
D
C
I
F
F
A
A
G
P
A
K
G
A
R
A
L
L
G
A
T
R
I
E
I
A
K
R
L
---
D
L
I
--
D
P
N
A
W
A
F
T
W
V
V
D
F
P
M
F
E
-
A
A
D
E
ATAAGDVAVG
S
G
A
W
T
A
M
H
H
A
F
T
A
P
K
P
D
S
V
D
T
F
D
S
D
P
G
N
A
L
S
D
A
Y
D
I
V
C
N
G
N
E
I
G
G
G
S
I
R
I
H
R
R
D
I
Q
E
R
V
F
A
M
M
G
I
D
H
D
E
A
Q
E
K
F
G
F
L
L
D
A
F
S
Y
G
A
P
P
H
G
G
I
A
F
G
W
D
R
I
T
A
L
L
A
G
V
D
S
I
R
E
V
I
A
F
P
K
S
G
G
G
V
D
P
L
T
D
A
P
A
P
I
T
P
Q
Q
R
K
E
S
G
-----
1
PsiBlast_PDB
91.66
41%
-78
- C4 -
4O2D
3
SYDND_MYCS2
A:
[25-603]
----
R
T
H
A
A
G
S
L
R
P
A
D
A
G
Q
T
V
T
L
A
G
W
V
A
R
R
R
D
H
G
G
V
I
F
I
D
L
R
D
A
S
G
V
S
Q
V
V
F
-
R
-
E
------
G
---
D
V
L
A
A
A
-
H
R
L
R
A
E
F
C
V
A
V
T
G
V
V
E
V
R
P
E
G
N
E
N
P
E
I
P
T
G
Q
I
E
V
N
A
T
E
L
T
V
L
G
E
------------------
S
A
P
L
P
F
Q
L
------
D
E
Q
A
G
E
E
A
R
L
K
Y
R
Y
L
D
L
R
R
E
G
P
G
N
A
L
R
L
R
S
K
V
N
A
A
A
R
S
V
L
A
E
-
H
D
F
V
E
I
E
T
P
T
L
T
R
S
T
P
E
G
A
R
D
F
L
V
P
A
R
L
Q
P
G
S
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
V
A
G
M
E
R
Y
Y
Q
I
A
R
C
Y
R
D
E
D
F
--
D
R
Q
P
-
E
F
T
Q
L
D
M
E
M
S
F
V
-
E
A
D
D
V
I
A
I
S
E
Q
V
L
K
A
V
W
A
T
I
G
-
Y
D
-------------
L
P
L
P
-
L
P
R
I
S
Y
E
E
A
M
R
R
F
G
S
D
K
P
D
L
R
F
G
I
E
L
V
E
C
T
E
Y
F
K
D
T
T
F
R
V
F
Q
--
A
P
Y
-------
V
G
A
V
V
M
P
G
G
A
S
Q
P
R
R
T
L
D
G
W
Q
E
F
A
-
K
Q
R
G
H
K
G
L
A
Y
----
V
L
V
G
E
D
G
----
T
L
G
G
------
P
V
A
K
N
-
L
S
D
A
E
R
D
G
L
V
A
H
V
G
A
N
P
G
D
C
I
F
F
A
A
G
P
A
K
G
A
R
A
L
L
G
A
T
R
I
E
I
A
K
R
L
---
D
L
I
--
D
P
N
A
W
A
F
T
W
V
V
D
F
P
M
F
E
-
A
A
D
E
A
T
A
A
GDVAVG
S
G
A
W
T
A
M
H
H
A
F
T
A
P
K
P
D
S
V
D
T
F
D
S
D
P
G
N
A
L
S
D
A
Y
D
I
V
C
N
G
N
E
I
G
G
G
S
I
R
I
H
R
R
D
I
Q
E
R
V
F
A
M
M
G
I
D
H
D
E
A
Q
E
K
F
G
F
L
L
D
A
F
S
Y
G
A
P
P
H
G
G
I
A
F
G
W
D
R
I
T
A
L
L
A
G
V
D
S
I
R
E
V
I
A
F
P
K
S
G
G
G
V
D
P
L
T
D
A
P
A
P
I
T
P
Q
Q
R
K
E
S
G
I
D
---
3
PsiBlast_PDB
91.38
41%
-78
- C4 -
1C0A
2
SYD_ECOLI
A:
[2-585]
----
R
T
E
Y
C
G
Q
L
R
L
S
H
V
G
Q
Q
V
T
L
C
G
W
V
N
R
R
R
D
L
G
S
L
I
F
I
D
M
R
D
R
E
G
I
V
Q
V
F
F
-
D
P
D
------
R
---
A
D
A
L
K
L
A
S
E
L
R
N
E
F
C
I
Q
V
T
G
T
V
R
A
R
D
E
K
N
I
N
R
D
M
A
T
G
E
I
E
V
L
A
S
S
L
T
I
I
N
------------------
R
A
D
V
L
P
L
D
S
------
N
H
V
N
T
E
E
A
R
L
K
Y
R
Y
L
D
L
R
R
P
E
M
A
Q
R
L
K
T
R
A
K
I
T
S
L
V
R
R
F
M
D
D
-
H
G
F
L
D
I
E
T
P
M
L
T
K
A
T
P
E
G
A
R
D
Y
L
V
P
S
R
V
H
K
G
K
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
M
S
G
F
D
R
Y
Y
Q
I
V
K
C
F
R
D
E
D
L
R
A
D
R
Q
P
-
E
F
T
Q
I
D
V
E
T
S
F
M
-
T
A
P
Q
V
R
E
V
M
E
A
L
V
R
H
L
W
L
E
V
--
K
G
-------------
V
D
L
G
D
F
P
V
M
T
F
A
E
A
E
R
R
Y
G
S
D
K
P
D
L
R
N
P
M
E
L
T
D
V
A
D
L
L
K
S
V
E
F
A
V
F
A
G
P
A
N
D
P
-
K
G
R
-
V
A
-
A
L
R
V
P
G
G
A
S
L
T
R
K
Q
I
D
E
Y
G
N
F
V
-
K
I
Y
G
A
K
G
L
A
Y
----
I
K
V
N
E
------
R
A
K
G
LEGINS
P
V
A
K
F
-
L
N
A
E
I
I
E
D
I
L
D
R
T
A
A
Q
D
G
D
M
I
F
F
G
A
D
N
K
K
I
V
A
D
A
M
G
A
L
R
L
K
V
G
K
D
L
---
G
L
T
--
D
E
S
K
W
A
P
L
W
V
I
D
F
P
M
F
--
E
D
D
G
----------
E
G
G
L
T
A
M
H
H
P
F
T
S
P
K
D
M
T
A
A
E
L
K
A
A
P
E
N
A
V
A
N
A
Y
D
M
V
I
N
G
Y
E
V
G
G
G
S
V
R
I
H
N
G
D
M
Q
Q
T
V
F
G
I
L
G
I
N
E
E
E
Q
R
E
K
F
G
F
L
L
D
A
L
K
Y
G
T
P
P
H
A
G
L
A
F
G
L
D
R
L
T
M
L
L
T
G
T
D
N
I
R
D
V
I
A
F
P
K
T
T
A
A
A
C
L
M
T
E
A
P
S
F
A
N
P
T
A
L
A
E
L
S
I
Q
V
V
K
4
PsiBlast_PDB
90.91
41%
-83
- C4 -
1EQR
1
SYD_ECOLI
A:
[2-585]
----
R
T
E
Y
C
G
Q
L
R
L
S
H
V
G
Q
Q
V
T
L
C
G
W
V
N
R
R
R
D
L
G
S
L
I
F
I
D
M
R
D
R
E
G
I
V
Q
V
F
F
-
D
P
D
------
R
---
A
D
A
L
K
L
A
S
E
L
R
N
E
F
C
I
Q
V
T
G
T
V
R
A
R
D
E
K
N
I
N
R
D
M
A
T
G
E
I
E
V
L
A
S
S
L
T
I
I
N
------------------
R
A
D
V
L
P
L
D
S
------
N
H
V
N
T
E
E
A
R
L
K
Y
R
Y
L
D
L
R
R
P
E
M
A
Q
R
L
K
T
R
A
K
I
T
S
L
V
R
R
F
M
D
D
-
H
G
F
L
D
I
E
T
P
M
L
T
K
A
T
P
E
G
A
R
D
Y
L
V
P
S
R
V
H
K
G
K
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
M
S
G
F
D
R
Y
Y
Q
I
V
K
C
F
R
D
E
D
L
R
A
D
R
Q
P
-
E
F
T
Q
I
D
V
E
T
S
F
M
-
T
A
P
Q
V
R
E
V
M
E
A
L
V
R
H
L
W
L
E
V
--
K
G
-------------
V
D
L
G
D
F
P
V
M
T
F
A
E
A
E
R
R
Y
G
S
D
K
P
D
L
R
N
P
M
E
L
T
D
V
A
D
L
L
K
S
V
E
F
A
V
F
A
G
P
A
N
D
P
-
K
G
R
-
V
A
-
A
L
R
V
P
G
G
A
S
L
T
R
K
Q
I
D
E
Y
G
N
F
V
-
K
I
Y
G
A
K
G
L
A
Y
----
I
K
V
N
E
------
R
A
K
G
LEGINS
P
V
A
K
F
-
L
N
A
E
I
I
E
D
I
L
D
R
T
A
A
Q
D
G
D
M
I
F
F
G
A
D
N
K
K
I
V
A
D
A
M
G
A
L
R
L
K
V
G
K
D
L
---
G
L
T
--
D
E
S
K
W
A
P
L
W
V
I
D
F
P
M
F
--
E
D
D
G
----------
E
G
G
L
T
A
M
H
H
P
F
T
S
P
K
D
M
T
A
A
E
L
K
A
A
P
E
N
A
V
A
N
A
Y
D
M
V
I
N
G
Y
E
V
G
G
G
S
V
R
I
H
N
G
D
M
Q
Q
T
V
F
G
I
L
G
I
N
E
E
E
Q
R
E
K
F
G
F
L
L
D
A
L
K
Y
G
T
P
P
H
A
G
L
A
F
G
L
D
R
L
T
M
L
L
T
G
T
D
N
I
R
D
V
I
A
F
P
K
T
T
A
A
A
C
L
M
T
E
A
P
S
F
A
N
P
T
A
L
A
E
L
S
I
Q
V
V
K
10
PsiBlast_PDB
90.60
40%
-74
- C4 -
1L0W
-
SYD_THETH
A:
[3-578]
----
R
T
H
Y
A
G
S
L
R
E
T
H
V
G
E
E
V
V
L
E
G
W
V
N
R
R
R
D
L
G
G
L
I
F
L
D
L
R
D
R
E
G
L
V
Q
L
V
A
-
H
P
A
------
S
---
P
A
Y
A
T
A
-
E
R
V
R
P
E
W
V
V
R
A
K
G
L
V
R
L
R
P
E
P
--
N
P
R
L
A
T
G
R
V
E
V
E
L
S
A
L
E
V
L
A
E
A
-
K
---
T
P
P
F
P
V
D
A
G
W
R
G
E
E
E
K
E
A
S
E
------------
E
L
R
L
K
Y
R
Y
L
D
L
R
R
R
R
M
Q
E
N
L
R
L
R
H
R
V
I
K
A
I
W
D
F
L
D
R
-
E
G
F
V
Q
V
E
T
P
F
L
T
K
S
T
P
E
G
A
R
D
F
L
V
P
Y
R
H
E
P
G
L
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
M
L
M
V
A
G
L
D
R
Y
F
Q
I
A
R
C
F
R
D
E
D
L
R
A
D
R
Q
P
-
D
F
T
Q
L
D
L
E
M
S
F
V
-
E
V
E
D
V
L
E
L
N
E
R
L
M
A
H
V
F
R
E
A
L
G
V
E
-------------
L
P
L
P
-
F
P
R
L
S
Y
E
E
A
M
E
R
Y
G
S
D
K
P
D
L
R
F
G
L
E
L
K
E
V
G
P
L
F
R
Q
S
G
F
R
V
F
Q
--
E
-----
A
E
-
S
V
K
A
L
A
L
P
K
A
L
S
R
K
E
V
---
A
E
L
E
E
V
A
K
R
H
K
A
Q
G
L
A
W
----
A
R
V
E
E
G
G
----
F
S
G
G
-------
V
A
K
F
-
L
E
P
V
R
-
E
A
L
L
Q
A
T
E
A
R
P
G
D
T
L
L
F
V
A
G
P
R
K
V
A
A
T
A
L
G
A
V
R
L
R
A
A
D
L
L
---
G
L
K
--
R
E
G
-
F
R
F
L
W
V
V
D
F
P
L
L
E
-
W
D
E
E
----------
E
E
A
W
T
Y
M
H
H
P
F
T
S
P
H
P
E
D
L
P
L
L
E
K
D
P
G
R
V
R
A
L
A
Y
D
L
V
L
N
G
V
E
V
G
G
G
S
I
R
I
H
D
P
R
L
Q
A
R
V
F
R
L
L
G
I
G
E
E
E
Q
R
E
K
F
G
F
F
L
E
A
L
E
Y
G
A
P
P
H
G
G
I
A
W
G
L
D
R
L
L
A
L
M
T
G
S
P
S
I
R
E
V
I
A
F
P
K
N
K
E
G
K
D
P
L
T
G
A
P
S
P
V
P
E
E
Q
L
R
E
L
G
L
M
V
V
R
23
PsiBlast_CBE
90.53
41%
-82
- C4 -
1EQR
1
SYD_ECOLI
C:
[2-585]
----
R
T
E
Y
C
G
Q
L
R
L
S
H
V
G
Q
Q
V
T
L
C
G
W
V
N
R
R
R
D
L
G
S
L
I
F
I
D
M
R
D
R
E
G
I
V
Q
V
F
F
-
D
P
D
------
R
---
A
D
A
L
K
L
A
S
E
L
R
N
E
F
C
I
Q
V
T
G
T
V
R
A
R
D
E
K
N
I
N
R
D
M
A
T
G
E
I
E
V
L
A
S
S
L
T
I
I
N
------------------
R
A
D
V
L
P
L
D
S
------
N
H
V
N
T
E
E
A
R
L
K
Y
R
Y
L
D
L
R
R
P
E
M
A
Q
R
L
K
T
R
A
K
I
T
S
L
V
R
R
F
M
D
D
-
H
G
F
L
D
I
E
T
P
M
L
T
K
A
T
P
E
G
A
R
D
Y
L
V
P
S
R
V
H
K
G
K
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
M
S
G
F
D
R
Y
Y
Q
I
V
K
C
F
R
D
E
D
L
R
A
D
R
Q
P
-
E
F
T
Q
I
D
V
E
T
S
F
M
-
T
A
P
Q
V
R
E
V
M
E
A
L
V
R
H
L
W
L
E
V
--
K
G
-------------
V
D
L
G
D
F
P
V
M
T
F
A
E
A
E
R
R
Y
G
S
D
K
P
D
L
R
N
P
M
E
L
T
D
V
A
D
L
L
K
S
V
E
F
A
V
F
A
GP
A
N
D
P
-
K
G
R
-
V
A
-
A
L
R
V
P
G
G
A
S
L
T
R
K
Q
I
D
E
Y
G
N
F
V
-
K
I
Y
G
A
K
G
L
A
Y
----
I
K
V
N
E
------
R
A
K
G
LEGINS
P
V
A
K
F
-
L
N
A
E
I
I
E
D
I
L
D
R
T
A
A
Q
D
G
D
M
I
F
F
G
A
D
N
K
K
I
V
A
D
A
M
G
A
L
R
L
K
V
G
K
D
L
---
G
L
T
--
D
E
S
K
W
A
P
L
W
V
I
D
F
P
M
F
--
E
D
D
G
----------
E
G
G
L
T
A
M
H
H
P
F
T
S
P
K
D
M
T
A
A
E
L
K
A
A
P
E
N
A
V
A
N
A
Y
D
M
V
I
N
G
Y
E
V
G
G
G
S
V
R
I
H
N
G
D
M
Q
Q
T
V
F
G
I
L
G
I
N
E
E
E
Q
R
E
K
F
G
F
L
L
D
A
L
K
Y
G
T
P
P
H
A
G
L
A
F
G
L
D
R
L
T
M
L
L
T
G
T
D
N
I
R
D
V
I
A
F
P
K
T
T
A
A
A
C
L
M
T
E
A
P
S
F
A
N
P
T
A
L
A
E
L
S
I
Q
V
V
K
25
PsiBlast_CBE
90.18
40%
-71
- C4 -
1G51
3
SYD_THETH
B:
[3-578]
----
R
T
H
Y
A
G
S
L
R
E
T
H
V
G
E
E
V
V
L
E
G
W
V
N
R
R
R
D
L
G
G
L
I
F
L
D
L
R
D
R
E
G
L
V
Q
L
V
A
-
H
P
A
------
S
---
P
A
Y
A
T
A
-
E
R
V
R
P
E
W
V
V
R
A
K
G
L
V
R
L
R
P
E
P
--
N
P
R
L
A
T
G
R
V
E
V
E
L
S
A
L
E
V
L
A
E
A
-
K
---
T
P
P
F
P
V
D
A
G
W
R
G
E
E
E
K
E
A
S
E
------------
E
L
R
L
K
Y
R
Y
L
D
L
R
R
R
R
M
Q
E
N
L
R
L
R
H
R
V
I
K
A
I
W
D
F
L
D
R
-
E
G
F
V
Q
V
E
T
P
F
L
T
K
S
T
P
E
G
A
R
D
F
L
V
P
Y
R
H
E
P
G
L
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
M
L
M
V
A
G
L
D
R
Y
F
Q
I
A
R
C
F
R
D
E
D
L
R
A
D
R
Q
P
-
D
F
T
Q
L
D
L
E
M
S
F
V
-
E
V
E
D
V
L
E
L
N
E
R
L
M
A
H
V
F
R
E
A
L
G
V
E
-------------
L
P
L
P
-
F
P
R
L
S
Y
E
E
A
M
E
R
Y
G
S
D
K
P
D
L
R
F
G
L
E
L
K
E
V
G
P
L
F
R
Q
S
G
F
R
V
F
Q
--
E
-----
A
E
-
S
V
K
A
L
A
L
P
K
A
L
S
R
K
E
V
---
A
E
L
E
E
V
A
K
R
H
K
A
Q
G
L
A
W
----
A
R
V
E
E
G
G
----
F
S
G
G
-------
V
A
K
F
-
L
E
P
V
R
-
E
A
L
L
Q
A
T
E
A
R
P
G
D
T
L
L
F
V
A
G
P
R
K
V
A
A
T
A
L
G
A
V
R
L
R
A
A
D
L
L
---
G
L
K
--
R
E
G
-
F
R
F
L
W
V
V
D
F
P
L
L
E
-
W
D
E
E
----------
E
E
A
W
T
Y
M
H
H
P
F
T
S
P
H
P
E
D
L
P
L
L
E
K
D
P
G
R
V
R
A
L
A
Y
D
L
V
L
N
G
V
E
V
G
G
G
S
I
R
I
H
D
P
R
L
Q
A
R
V
F
R
L
L
G
I
G
E
E
E
Q
R
E
K
F
G
F
F
L
E
A
L
E
Y
G
A
P
P
H
G
G
I
A
W
G
L
D
R
L
L
A
L
M
T
G
S
P
S
I
R
E
V
I
A
F
P
K
N
K
E
G
K
D
P
L
T
G
A
P
S
P
V
P
E
E
Q
L
R
E
L
G
L
M
V
V
R
9
PsiBlast_PDB
90.16
40%
-71
- C4 -
1G51
2
SYD_THETH
A:
[3-578]
----
R
T
H
Y
A
G
S
L
R
E
T
H
V
G
E
E
V
V
L
E
G
W
V
N
R
R
R
D
L
G
G
L
I
F
L
D
L
R
D
R
E
G
L
V
Q
L
V
A
-
H
P
A
------
S
---
P
A
Y
A
T
A
-
E
R
V
R
P
E
W
V
V
R
A
K
G
L
V
R
L
R
P
E
P
--
N
P
R
L
A
T
G
R
V
E
V
E
L
S
A
L
E
V
L
A
E
A
-
K
---
T
P
P
F
P
V
D
A
G
W
R
G
E
E
E
K
E
A
S
E
------------
E
L
R
L
K
Y
R
Y
L
D
L
R
R
R
R
M
Q
E
N
L
R
L
R
H
R
V
I
K
A
I
W
D
F
L
D
R
-
E
G
F
V
Q
V
E
T
P
F
L
T
K
S
T
P
E
G
A
R
D
F
L
V
P
Y
R
H
E
P
G
L
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
M
L
M
V
A
G
L
D
R
Y
F
Q
I
A
R
C
F
R
D
E
D
L
R
A
D
R
Q
P
-
D
F
T
Q
L
D
L
E
M
S
F
V
-
E
V
E
D
V
L
E
L
N
E
R
L
M
A
H
V
F
R
E
A
L
G
V
E
-------------
L
P
L
P
-
F
P
R
L
S
Y
E
E
A
M
E
R
Y
G
S
D
K
P
D
L
R
F
G
L
E
L
K
E
V
G
P
L
F
R
Q
S
G
F
R
V
F
Q
--
E
-----
A
E
-
S
V
K
A
L
A
L
P
K
A
L
S
R
K
E
V
---
A
E
L
E
E
V
A
K
R
H
K
A
Q
G
L
A
W
----
A
R
V
E
E
G
G
----
F
S
G
G
-------
V
A
K
F
-
L
E
P
V
R
-
E
A
L
L
Q
A
T
E
A
R
P
G
D
T
L
L
F
V
A
G
P
R
K
V
A
A
T
A
L
G
A
V
R
L
R
A
A
D
L
L
---
G
L
K
--
R
E
G
-
F
R
F
L
W
V
V
D
F
P
L
L
E
-
W
D
E
E
----------
E
E
A
W
T
Y
M
H
H
P
F
T
S
P
H
P
E
D
L
P
L
L
E
K
D
P
G
R
V
R
A
L
A
Y
D
L
V
L
N
G
V
E
V
G
G
G
S
I
R
I
H
D
P
R
L
Q
A
R
V
F
R
L
L
G
I
G
E
E
E
Q
R
E
K
F
G
F
F
L
E
A
L
E
Y
G
A
P
P
H
G
G
I
A
W
G
L
D
R
L
L
A
L
M
T
G
S
P
S
I
R
E
V
I
A
F
P
K
N
K
E
G
K
D
P
L
T
G
A
P
S
P
V
P
E
E
Q
L
R
E
L
G
L
M
V
V
R
8
PsiBlast_PDB
89.80
40%
-74
- C4 -
1EFW
-
SYD_THETH
A:
[3-578]
----
R
T
H
Y
A
G
S
L
R
E
T
H
V
G
E
E
V
V
L
E
G
W
V
N
R
R
R
D
L
G
G
L
I
F
L
D
L
R
D
R
E
G
L
V
Q
L
V
A
-
H
P
A
------
S
---
P
A
Y
A
T
A
-
E
R
V
R
P
E
W
V
V
R
A
K
G
L
V
R
L
R
P
E
P
--
N
P
R
L
A
T
G
R
V
E
V
E
L
S
A
L
E
V
L
A
E
A
-
K
---
T
P
P
F
P
V
D
A
G
W
R
G
E
E
E
K
E
A
S
E
------------
E
L
R
L
K
Y
R
Y
L
D
L
R
R
R
R
M
Q
E
N
L
R
L
R
H
R
V
I
K
A
I
W
D
F
L
D
R
-
E
G
F
V
Q
V
E
T
P
F
L
T
K
S
T
P
E
G
A
R
D
F
L
V
P
Y
R
H
E
P
G
L
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
M
L
M
V
A
G
L
D
R
Y
F
Q
I
A
R
C
F
R
D
E
D
L
R
A
D
R
Q
P
-
D
F
T
Q
L
D
L
E
M
S
F
V
-
E
V
E
D
V
L
E
L
N
E
R
L
M
A
H
V
F
R
E
A
L
G
V
E
-------------
L
P
L
P
-
F
P
R
L
S
Y
E
E
A
M
E
R
Y
G
S
D
K
P
D
L
R
F
G
L
E
L
K
E
V
G
P
L
F
R
Q
S
G
F
R
V
F
Q
--
E
-----
A
E
-
S
V
K
A
L
A
L
P
K
A
L
S
R
K
E
V
---
A
E
L
E
E
V
A
K
R
H
K
A
Q
G
L
A
W
----
A
R
V
E
E
G
G
----
F
S
G
G
-------
V
A
K
F
-
L
E
P
V
R
-
E
A
L
L
Q
A
T
E
A
R
P
G
D
T
L
L
F
V
A
G
P
R
K
V
A
A
T
A
L
G
A
V
R
L
R
A
A
D
L
L
---
G
L
K
--
R
E
G
-
F
R
F
L
W
V
V
D
F
P
L
L
E
-
W
D
E
E
----------
E
E
A
W
T
Y
M
H
H
P
F
T
S
P
H
P
E
D
L
P
L
L
E
K
D
P
G
R
V
R
A
L
A
Y
D
L
V
L
N
G
V
E
V
G
G
G
S
I
R
I
H
D
P
R
L
Q
A
R
V
F
R
L
L
G
I
G
E
E
E
Q
R
E
K
F
G
F
F
L
E
A
L
E
Y
G
A
P
P
H
G
G
I
A
W
G
L
D
R
L
L
A
L
M
T
G
S
P
S
I
R
E
V
I
A
F
P
K
N
K
E
G
K
D
P
L
T
G
A
P
S
P
V
P
E
E
Q
L
R
E
L
G
L
M
V
V
R
21
PsiBlast_CBE
86.91
41%
-74
- C4 -
4O2D
3
SYDND_MYCS2
B:
[25-603]
----
R
T
H
A
A
G
S
L
R
P
A
D
A
G
Q
T
V
T
L
A
G
W
V
A
R
R
R
D
H
G
G
V
I
F
I
D
L
R
D
A
S
G
V
S
Q
V
V
F
-
R
-
E
------
G
---
D
V
L
A
A
A
-
H
R
L
R
A
E
F
C
V
A
V
T
G
V
V
E
V
R
P
E
G
N
E
N
P
E
I
P
T
G
Q
I
E
V
N
A
T
E
L
T
V
L
G
E
------------------
S
A
P
L
P
F
Q
L
------
D
E
Q
A
G
E
E
A
R
L
K
Y
R
Y
L
D
L
R
R
E
G
P
G
N
A
L
R
L
R
S
K
V
N
A
A
A
R
S
V
L
A
E
-
H
D
F
V
E
I
E
T
P
T
L
T
R
S
T
P
E
G
A
R
D
F
L
V
P
A
R
L
Q
P
G
S
F
Y
A
L
P
Q
S
P
Q
L
F
K
Q
L
L
M
V
A
G
M
E
R
Y
Y
Q
I
A
R
C
Y
R
D
E
D
F
--
D
R
Q
P
-
E
F
T
Q
L
D
M
E
M
S
F
V
-
E
A
D
D
V
I
A
I
S
E
Q
V
L
K
A
V
W
A
T
I
G
-
Y
D
-------------
L
P
L
P
-
L
P
R
I
S
Y
E
E
A
M
R
R
F
G
S
D
K
P
D
L
R
F
G
I
E
L
V
E
C
T
E
Y
F
------------
P
Y
-------
V
G
A
V
V
M
P
------------
W
Q
E
F
A
-
K
Q
R
G
----------------------------------------------------------
F
F
A
A
G
P
A
K
G
A
R
A
L
L
G
A
T
R
I
E
I
A
K
R
L
---
D
L
I
--
D
P
N
A
W
A
F
T
W
V
V
D
F
P
M
F
E
-
A
A
D
E
A
T
A
A
GDVAVG
S
G
A
W
T
A
M
H
H
A
F
T
A
P
K
P
D
S
V
D
T
F
D
S
D
P
G
N
A
L
S
D
A
Y
D
I
V
C
N
G
N
E
I
G
G
G
S
I
R
I
H
R
R
D
I
Q
E
R
V
F
A
M
M
G
I
D
H
D
E
A
Q
E
K
F
G
F
L
L
D
A
F
S
Y
G
A
P
P
H
G
G
I
A
F
G
W
D
R
I
T
A
L
L
A
G
V
D
S
I
R
E
V
I
A
F
P
K
S
G
G
G
V
D
P
L
T
D
A
P
A
P
I
T
P
Q
Q
R
K
E
S
G
I
D
---
11
PsiBlast_PDB
81.67
33%
-80
- C4 -
4AH6
-
SYDM_HUMAN
A:
[50-630]
----
R
T
N
T
C
G
E
L
R
S
S
H
L
G
Q
E
V
T
L
C
G
W
I
Q
Y
R
R
Q
N
---
T
F
L
V
L
R
D
F
D
G
L
V
Q
V
I
I
-
P
Q
D
ESA
A
S
V
K
---
K
I
L
C
E
A
-
P
V
---
E
S
V
V
Q
V
S
G
T
V
I
S
R
P
A
G
Q
E
N
P
K
M
P
T
G
E
I
E
I
K
V
K
T
A
E
L
L
N
A
C
----------------
K
K
L
P
F
E
I
K
N
------
F
V
K
K
T
E
A
L
R
L
Q
Y
R
Y
L
D
L
R
S
F
Q
M
Q
Y
N
L
R
L
R
S
Q
M
V
M
K
M
R
E
Y
L
C
N
L
H
G
F
V
D
I
E
T
P
T
L
F
K
R
T
P
G
G
A
K
E
F
L
V
P
S
R
-
E
P
G
K
F
Y
S
L
P
Q
S
P
Q
Q
F
K
Q
L
L
M
V
G
G
L
D
R
Y
F
Q
V
A
R
C
Y
R
D
E
G
S
R
P
D
R
Q
P
-
E
F
T
Q
I
D
I
E
M
S
F
V
-
D
Q
T
G
I
Q
S
L
I
E
G
L
L
Q
Y
S
W
P
N
-
D
K
D
P
-------------
V
V
V
P
-
F
P
T
M
T
F
A
E
V
L
A
T
Y
G
T
D
K
P
D
T
R
F
G
M
K
I
I
D
I
S
D
V
F
R
N
T
E
I
G
F
L
Q
--
D
A
L
S
-
K
P
H
G
T
V
K
A
I
C
I
P
E
G
A
K
----
Y
L
K
R
K
D
I
E
S
I
R
N
F
A
A
D
H
F
N
Q
E
I
L
P
V
F
L
N
A
N
R
----
N
W
N
S
------
P
V
A
N
F
I
M
E
S
Q
R
L
E
L
I
R
-
L
M
E
T
Q
E
E
D
V
V
L
L
T
A
G
E
H
N
K
A
C
S
L
L
G
K
L
R
L
E
C
A
D
L
L
E
T
R
G
V
V
LR
D
P
T
L
F
S
F
L
W
V
V
D
F
P
L
F
L
P
K
E
E
N
----------
P
R
E
L
E
S
A
H
H
P
F
T
A
P
H
P
S
D
I
H
L
L
Y
T
E
P
K
K
A
R
S
Q
H
Y
D
L
V
L
N
G
N
E
I
G
G
G
S
I
R
I
H
N
A
E
L
Q
R
Y
I
L
A
T
--
L
L
K
E
D
V
-
K
M
L
S
H
L
L
Q
A
L
D
Y
G
A
P
P
H
G
G
I
A
L
G
L
D
R
L
I
C
L
V
T
G
S
P
S
I
R
D
V
I
A
F
P
K
S
F
R
G
H
D
L
M
S
N
T
P
D
S
V
P
P
E
E
L
K
P
Y
H
-----
29
HHSearch
67.78
28%
-80
- C4 -
3NEM
1
SYD_THEKO
A:
[1-436]
--
M
Y
R
T
H
Y
S
S
E
I
T
E
E
L
N
G
Q
K
V
K
V
A
G
W
V
W
E
V
K
D
L
G
G
I
K
F
L
W
I
R
D
R
D
G
I
V
Q
I
T
A
-
P
K
K
------
K
VD
P
E
L
F
K
L
I
-
P
K
L
R
S
E
D
V
V
A
V
E
G
V
V
N
F
T
P
K
A
-------
K
L
G
F
E
I
L
P
E
K
I
V
V
L
N
R
A
E
T
---------------
P
L
P
L
D
P
T
G
------
K
V
K
A
E
L
D
T
R
L
D
N
R
F
M
D
L
R
R
P
E
V
M
A
I
F
K
I
R
S
S
V
F
K
A
V
R
D
F
F
H
E
-
N
G
F
I
E
I
H
T
P
K
I
I
A
T
A
T
E
G
G
T
E
L
F
P
M
K
Y
--
F
E
E
D
A
F
L
A
Q
S
P
Q
L
Y
K
Q
I
M
M
A
S
G
L
D
R
V
Y
E
I
A
P
I
F
R
A
E
E
H
N
T
T
R
H
L
N
E
A
W
S
I
D
S
E
M
A
F
I
E
D
E
E
E
V
M
S
F
L
E
R
L
V
A
H
A
I
N
Y
V
R
E
H
N
A
K
E
L
D
I
L
N
F
E
L
E
E
P
K
L
P
-
F
P
R
V
S
Y
D
K
A
L
E
I
L
G
D
L
G
K
E
I
P
W
G
------------------------------------------------
E
--------------------------
D
------
I
D
T
-----------------------------------------
E
G
E
R
L
L
G
K
Y
---
M
M
E
N
E
-----------
N
A
P
L
Y
F
L
Y
Q
Y
P
S
-----------------------
E
A
K
P
F
Y
I
M
K
Y
D
N
------
K
--
P
E
I
C
R
A
F
D
L
E
Y
R
G
V
E
I
S
S
G
G
Q
R
E
H
R
H
D
I
L
V
E
Q
I
K
E
K
G
L
N
P
----
E
S
F
E
F
Y
L
K
A
F
R
Y
G
M
P
P
H
G
G
F
G
L
G
A
E
R
L
I
K
Q
M
L
D
L
P
N
I
R
E
V
I
L
F
P
R
D
R
R
R
L
T
P
----------------------
27
HHSearch
66.36
28%
-73
- C4 -
1WYD
3
SYDND_SULTO
A:
[1-428]
--
M
Y
R
S
H
F
I
A
D
V
T
P
E
Y
D
G
K
E
V
I
W
A
G
W
V
H
L
L
R
D
L
G
G
K
K
F
I
I
L
R
D
K
T
G
L
G
Q
V
V
V
-
D
K
N
------
S
---
S
A
F
G
I
S
-
Q
E
L
T
Q
E
S
V
I
Q
V
R
G
I
V
K
A
D
K
R
-------
A
P
R
G
I
E
L
H
A
E
E
I
T
L
L
S
K
A
K
A
---------------
P
L
P
L
D
V
S
G
------
K
V
K
A
D
I
D
T
R
L
R
E
R
V
L
D
L
R
R
Q
E
M
Q
A
V
I
K
I
Q
S
L
A
L
K
A
F
R
E
T
L
Y
K
-
E
G
F
I
E
I
F
T
P
K
I
I
A
S
A
T
E
G
G
A
Q
L
F
P
V
I
Y
--
F
G
K
E
A
F
L
A
Q
S
P
Q
L
Y
K
E
L
M
-
A
G
V
V
E
R
V
F
E
V
A
P
A
W
R
A
E
E
S
D
T
P
F
H
L
A
E
F
I
S
M
D
V
E
M
A
F
A
-
D
Y
N
D
V
M
Q
L
L
E
K
I
L
H
N
I
V
K
T
I
K
E
E
G
K
E
E
L
K
I
L
NYEPPE
V
K
I
P
-
I
K
R
L
K
Y
T
E
A
I
E
I
L
R
S
K
G
Y
N
I
K
F
G
--------------------------------------------------------------------------
D
D
------
I
G
T
-----------------------------------------
P
E
L
R
-------
I
L
N
E
E
L
-----------
K
E
D
L
Y
F
I
V
D
W
P
S
-----------------------
D
A
R
P
F
Y
T
K
S
K
S
E
---------
P
E
L
S
E
S
F
D
L
I
Y
K
F
L
E
I
V
S
G
S
T
R
N
H
K
R
E
V
L
E
E
A
L
K
K
K
G
L
K
P
----
E
S
F
E
F
F
L
K
W
F
D
Y
G
M
P
P
H
A
G
F
G
M
G
L
A
R
L
M
V
M
L
T
G
I
Q
S
V
K
E
I
V
P
F
P
R
D
K
K
R
L
T
P
----------------------