@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0019: (2015-11-27 )
MFEIIKKSIEWGGRTLSLETGKIARQADGSVVVNYGDTSILVTVVRKKKEEIVDFLPLNVQFIAKSYAMGRIPGGFFKREGKPSDRETLISRVIDRSIRPLFLEGFHDEISIVCNLLTYDTVNPPEVPALIGAVAALAISGVPFHFIIAGVLVGCDGNNNYILNPSVQEMKVSSLDLFLSGDERSILMVESEAKELPEENILNAIKFGHEHLQPVIKLIKEFADTIGNKFDSFAPIDISDIMQDLEKHSKDFEEAYSQTVKQERAQTLETIRNNILNPLKEAGKDEKLITQAVKNFERSLLRKIIREKGTRIDGRKYDEIRQIEVEVDILSRTHGSALFTRGSTQALVVTALGTTQDEQIVDDIEGDRREHFMLHYNFPSFAVGDASAIRAPGRREIGHGKLAWKAIHPVLPDKSEFPYTIRVVSEIMESDGSSSMATVCGTSLALMDTGVPIKSPVAGIAMGLIKDKNDYVILSDILGDEDYLGDMDFKVAGTSEGITALQMDMKISGISFEIVEKSLEQAKAGRLHILEKMNSVISEHSDDVKGHAPRMVSFYIDKDKISAAIGAKGKNIRSVCERSNAKIEIGDDGKVSVFAMSSAEAEIAKNMMIDSITELEQGAIVDVKVVKIDKSIVELELFNGRKGKMHISEVANQHIESIESILKQGDTFKALVIDFEKGGCPKLSRRRVDQETGDFFEGELYNEEKKDSSNDRDYYNSPFNRKSGHRKRPVHSRSSFSNRNNRPKFGNDDSSSSFY
Atome Classification :
(29 SA)
.........10........20........30........40....-....-50.-.......60........70........80........90........100.......110.......120.......130.......140.......150..-.....160.......170.......180..-..-....190.......200.......210----.......220......-.230.....--..240--...--.....-250-......--..260---...-----......270....------...-----280-.--.......290.......300.......310.......320.......330.......340.......350....----.----.----.360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460......-------.-------470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.-......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
F
E
I
I
K
K
S
I
EWG
G
R
T
L
S
LET
G
K
IARQADG
S
V
V
V
N
YGD
T
S
I
L
V
T
V
V
-
R
K
K
K
-
E
E
I
-
V
D
FLPL
N
V
Q
F
I
A
K
S
YAMGRIPG
G
F
FKREGKPS
D
R
E
T
L
I
S
R
V
I
DRSI
R
P
L
F
L
E
GF
H
D
E
I
S
I
V
C
N
L
L
TYDTVNPP
E
V
P
A
L
I
G
A
V
A
A
L
A
ISG
V
P
F
H
F
I
I
A
G
V
L
V
G-CDGNN
N
Y
I
LNP
S
V
Q
E
M
K
V
S
S
L
D
L
F
LSG-D
E
-
R
S
-
I
L
M
V
E
S
E
A
K
EL
P
E
E
N
I
L
N
A
I
K
F
G
H
E
H
L
----
Q
P
V
I
K
L
I
K
E
F
A
D
T
IGN-KFDSFAPI
D
--
I
S
D
I
---
M
Q
D
--
L
E
K
H
S
-
K
D
--
F
E
E
A
Y
S
--
Q
T
V
-----
K
Q
E
-----
R
A
Q
T
L
E
T
I
R
N
N
I
L
------
N
P
L
-----
K
E
--A--GK
D
E
K
L
I
T
Q
A
V
K
N
F
E
R
S
L
L
R
K
I
I
R
EKGTRIDGRKY
D
E
I
R
Q
I
E
V
E
V
D
I
LSRTHG
S
A
L
F
TRGS
T
Q
A
L
V
V
T
ALGTT
Q
----
D
----
E
----
Q
I
V
D
D
IEGDR
R
E
H
F
M
L
H
YNFPSFAVGD
A
S
AIRAPGRREIGHG
K
L
A
W
K
AIHPVLPDKSEFP
Y
T
I
R
V
V
S
E
I
M
ESDGSS
S
M
A
T
V
CG
T
S
L
A
L
M
DTGVPIKS
P
V
A
G
I
A
M
G
LIKDK-------N-------
D
Y
V
I
L
S
D
ILGDEDYLGDM
D
F
K
V
AGTSEG
I
T
A
L
Q
M
D
M
K
ISG
I
S
F
E
I
V
E
K
S
L
E
Q
AKAG
R
L
H
I
L
E
K
M
N
S
V
I
S
EHSDDVKGHA
P
R
M
V
S
F
Y
I
D
K
D
K
I
S
A
AIGAKG
K
N
I
R
S
V
C
E
RSN
A
K
I
E
IGDDG
K
V
S
V
F
A
MSS
A
E
A
E
I
A
K
N
M
M
I
D
S
I
T
-ELEQG
A
I
V
D
V
K
V
V
K
IDK
S
I
V
E
L
E
LFNGRKG
K
M
H
I
S
E
V
A
N
Q
H
I
E
S
I
E
S
I
L
KQGD
T
F
K
A
L
V
I
D
FEKGGCP
K
L
S
R
RRVDQETGDFFEGELYNEEKKDSSNDRDYYNSPFNRKSGHRKRPVHSRSSFSNRNNRPKFGNDDSSSSFY
2
PsiBlast_PDB
92.62
47%
-94
- C4 -
4AIM
2
PNP_CAUCR
A:
[15-710]
M
F
D
I
K
R
K
T
I
E
W
G
G
K
T
L
V
L
E
T
G
R
I
A
R
Q
A
D
G
A
V
L
A
T
M
G
E
T
V
V
L
A
T
A
V
-
F
A
K
S
-
Q
K
P
G
Q
D
F
F
P
L
T
V
N
Y
Q
E
K
T
F
A
A
G
K
I
P
G
G
F
F
K
R
E
G
R
P
S
E
K
E
T
L
V
S
R
L
I
D
R
P
I
R
P
L
F
V
K
G
F
K
N
E
V
Q
V
V
V
T
V
L
Q
H
D
L
E
N
D
P
D
I
L
G
M
V
A
A
S
A
A
L
C
L
S
G
A
P
F
M
G
P
I
G
A
A
R
V
G
W
V
D
G
A
--
Y
V
L
N
P
T
L
D
E
M
K
E
S
K
M
D
L
V
V
A
G
-
T
A
-
D
A
-
V
M
M
V
E
S
E
I
Q
E
L
S
E
E
I
V
L
G
G
V
N
F
A
H
Q
Q
M
----
Q
A
V
I
D
A
I
I
D
L
A
E
H
A
A
K
-
E
P
F
A
F
E
P
E
D
--
T
D
A
I
K
A
K
M
K
D
--
L
--
V
G
-
A
D
--
I
A
A
A
Y
K
--
I
Q
K
-----
K
Q
D
-----
R
Y
E
A
V
G
A
A
K
K
K
A
I
------
A
A
L
GLSDE
N
P
--
T
--
G
Y
D
P
L
K
L
G
A
I
F
K
E
L
E
A
D
V
V
R
R
G
I
L
D
T
G
L
R
I
D
G
R
D
V
K
T
V
R
P
I
L
G
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V
G
I
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
I
V
V
A
T
L
G
T
G
D
----
D
----
E
----
Q
F
I
D
A
L
E
G
T
Y
K
E
S
F
L
L
H
Y
N
F
P
P
Y
S
V
G
E
T
G
R
M
G
S
P
G
R
R
E
I
G
H
G
K
L
A
W
R
A
L
R
P
M
L
P
T
K
E
D
F
P
Y
T
I
R
L
V
S
E
I
T
E
S
N
G
S
S
S
M
A
T
V
C
G
S
S
L
A
M
M
D
A
G
V
P
L
V
R
P
V
S
G
I
A
M
G
L
I
L
E
Q
-------
D
-------
G
F
A
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
T
S
E
G
L
T
S
L
Q
M
D
I
K
I
A
G
I
T
P
A
I
M
E
Q
A
L
A
Q
A
K
E
G
R
A
H
I
L
G
E
M
N
K
A
M
D
A
P
R
A
D
V
G
D
F
A
P
K
I
E
T
I
N
I
P
T
D
K
I
R
E
V
I
G
S
G
G
K
V
I
R
E
I
V
A
T
T
G
A
K
V
D
I
N
D
D
G
V
V
K
V
S
A
S
D
G
A
K
I
K
A
A
I
D
-
W
I
K
S
I
T
D
E
A
E
I
G
K
I
Y
D
G
K
V
V
K
V
V
D
F
G
A
F
V
N
F
F
G
A
K
D
G
L
V
H
V
S
Q
I
S
N
E
R
V
A
K
P
S
D
V
L
K
E
G
Q
M
V
K
V
K
L
L
G
F
D
D
R
G
K
T
K
L
S
M
K
V
V
D
Q
-----------------------------------------------------------------
22
PsiBlast_CBE
89.80
47%
-97
- C4 -
4AM3
5
PNP_CAUCR
B:
[6-624]
M
F
D
I
K
R
K
T
I
E
W
G
G
K
T
L
V
L
E
T
G
R
I
A
R
Q
A
D
G
A
V
L
A
T
M
G
E
T
V
V
L
A
T
A
V
-
F
A
K
S
-
Q
K
P
G
Q
D
F
F
P
L
T
V
N
Y
Q
E
K
T
F
A
A
G
K
I
P
G
G
F
F
K
R
E
G
R
P
S
E
K
E
T
L
V
S
R
L
I
D
R
P
I
R
P
L
F
V
K
G
F
K
N
E
V
Q
V
V
V
T
V
L
Q
H
D
L
E
N
D
P
D
I
L
G
M
V
A
A
S
A
A
L
C
L
S
G
A
P
F
M
G
P
I
G
A
A
R
V
G
W
V
D
G
A
--
Y
V
L
N
P
T
L
D
E
M
K
E
S
K
M
D
L
V
V
A
G
-
T
A
-
D
A
-
V
M
M
V
E
S
E
I
Q
E
L
S
E
E
I
V
L
G
G
V
N
F
A
H
Q
Q
M
----
Q
A
V
I
D
A
I
I
D
L
A
E
H
A
A
K
-
E
P
F
A
F
E
P
E
D
--
T
D
A
I
KAK
M
K
D
--
L
--
V
G
-
A
D
--
I
A
A
A
Y
K
--
I
Q
K
-----
K
Q
D
-----
R
Y
E
A
V
G
A
A
K
K
K
A
I
------
A
A
L
GLSDE
N
P
--
T
--
G
Y
D
P
L
K
L
G
A
I
F
K
E
L
E
A
D
V
V
R
R
G
I
L
D
T
G
L
R
I
D
G
R
D
V
K
T
V
R
P
I
L
G
E
V
G
I
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
I
V
V
A
T
L
G
T
G
D
----
D
----
E
----
Q
F
I
D
A
L
E
G
T
Y
K
E
S
F
L
L
H
Y
N
F
P
P
Y
S
V
G
E
T
G
R
M
G
S
P
G
R
R
E
I
G
H
G
K
L
A
W
R
A
L
R
P
M
L
P
T
K
E
D
F
P
Y
T
I
R
L
V
S
E
I
T
E
S
N
G
S
S
S
M
A
T
V
C
G
S
S
L
A
M
M
D
A
G
V
P
L
V
R
P
V
S
G
I
A
M
G
L
I
L
E
Q
-------
D
-------
G
F
A
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
T
S
E
G
L
T
S
L
Q
M
D
I
K
I
A
G
I
T
P
A
I
M
E
Q
A
L
A
Q
A
K
E
G
R
A
H
I
L
G
E
M
N
K
A
M
D
A
P
R
A
D
V
G
D
F
A
P
K
I
E
T
I
N
I
P
T
D
K
I
R
E
V
I
G
S
G
G
K
V
I
R
E
I
V
A
T
T
G
A
K
V
D
I
N
D
D
G
V
V
K
V
S
A
S
D
G
A
K
I
K
A
A
I
D
-
W
I
K
S
I
T
D----------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
89.62
47%
-93
- C4 -
4AM3
5
PNP_CAUCR
A:
[6-625]
M
F
D
I
K
R
K
T
I
E
W
G
G
K
T
L
V
L
E
T
G
R
I
A
R
Q
A
D
G
A
V
L
A
T
M
G
E
T
V
V
L
A
T
A
V
-
F
A
K
S
-
Q
K
P
G
Q
D
F
F
P
L
T
V
N
Y
Q
E
K
T
F
A
A
G
K
I
P
G
G
F
F
K
R
E
G
R
P
S
E
K
E
T
L
V
S
R
L
I
D
R
P
I
R
P
L
F
V
K
G
F
K
N
E
V
Q
V
V
V
T
V
L
Q
H
D
L
E
N
D
P
D
I
L
G
M
V
A
A
S
A
A
L
C
L
S
G
A
P
F
M
G
P
I
G
A
A
R
V
G
W
V
D
G
A
--
Y
V
L
N
P
T
L
D
E
M
K
E
S
K
M
D
L
V
V
A
G
-
T
A
-
D
A
-
V
M
M
V
E
S
E
I
Q
E
L
S
E
E
I
V
L
G
G
V
N
F
A
H
Q
Q
M
----
Q
A
V
I
D
A
I
I
D
L
A
E
H
A
A
K
-
E
P
F
A
F
E
P
E
D
--
T
D
A
I
K
A
K
M
K
D
--
L
--
V
G
-
A
D
--
I
A
A
A
Y
K
--
I
Q
K
-----
K
Q
D
-----
R
Y
E
A
V
G
A
A
K
K
K
A
I
------
A
A
L
G
L
S
DE
N
P
--
T
--
G
Y
D
P
L
K
L
G
A
I
F
K
E
L
E
A
D
V
V
R
R
G
I
L
D
T
G
L
R
I
D
G
R
D
V
K
T
V
R
P
I
L
G
E
V
G
I
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
I
V
V
A
T
L
G
T
G
D
----
D
----
E
----
Q
F
I
D
A
L
E
G
T
Y
K
E
S
F
L
L
H
Y
N
F
P
P
Y
S
V
G
E
T
G
R
M
G
S
P
G
R
R
E
I
G
H
G
K
L
A
W
R
A
L
R
P
M
L
P
T
K
E
D
F
P
Y
T
I
R
L
V
S
E
I
T
E
S
N
G
S
S
S
M
A
T
V
C
G
S
S
L
A
M
M
D
A
G
V
P
L
V
R
P
V
S
G
I
A
M
G
L
I
L
E
Q
-------
D
-------
G
F
A
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
T
S
E
G
L
T
S
L
Q
M
D
I
K
I
A
G
I
T
P
A
I
M
E
Q
A
L
A
Q
A
K
E
G
R
A
H
I
L
G
E
M
N
K
A
M
D
A
P
R
A
D
V
G
D
F
A
P
K
I
E
T
I
N
I
P
T
D
K
I
R
E
V
I
G
S
G
G
K
V
I
R
E
I
V
A
T
T
G
A
K
V
D
I
N
D
D
G
V
V
K
V
S
A
S
D
G
A
K
I
K
A
A
I
D
-
W
I
K
S
I
T
D
E
---------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
88.41
47%
-93
- C4 -
4AM3
5
PNP_CAUCR
C:
[6-624]
M
F
D
I
K
R
K
T
I
E
W
G
G
K
T
L
V
L
E
T
G
R
I
A
R
Q
A
D
G
A
V
L
A
T
M
G
E
T
V
V
L
A
T
A
V
-
F
A
K
S
-
Q
K
P
G
Q
D
F
F
P
L
T
V
N
Y
Q
E
K
T
F
A
A
G
K
I
P
G
G
F
F
K
R
E
G
R
P
S
E
K
E
T
L
V
S
R
L
I
D
R
P
I
R
P
L
F
V
K
G
F
K
N
E
V
Q
V
V
V
T
V
L
Q
H
D
L
E
N
D
P
D
I
L
G
M
V
A
A
S
A
A
L
C
L
S
G
A
P
F
M
G
P
I
G
A
A
R
V
G
W
V
D
G
A
--
Y
V
L
N
P
T
L
D
E
M
K
E
S
K
M
D
L
V
V
A
G
-
T
A
-
D
A
-
V
M
M
V
E
S
E
I
Q
E
L
S
E
E
I
V
L
G
G
V
N
F
A
H
Q
Q
M
----
Q
A
V
I
D
A
I
I
D
L
A
E
H
A
A
K
-
E
P
F
A
F
E
P
E
D
--
T
D
A
I
KAK
M
K
D
--
L
--
V
G
-
A
D
--
I
A
A
A
Y
K
--
I
Q
K
-----
K
Q
D
-----
R
Y
E
A
V
G
A
A
K
K
K
A
I
------
A
A
L
GLSDE
N
P
--
T
--
G
Y
D
P
L
K
L
G
A
I
F
K
E
L
E
A
D
V
V
R
R
G
I
L
D
T
G
L
R
I
D
G
R
D
V
K
T
V
R
P
I
L
G
E
V
G
I
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
I
V
V
A
T
L
G
T
G
D
----
D
----
E
----
Q
F
I
D
A
L
E
G
T
Y
K
E
S
F
L
L
H
Y
N
F
P
P
Y
S
V
G
E
T
G
R
M
G
S
P
G
R
R
E
I
G
H
G
K
L
A
W
R
A
L
R
P
M
L
P
T
K
E
D
F
P
Y
T
I
R
L
V
S
E
I
T
E
S
N
G
S
S
S
M
A
T
V
C
G
S
S
L
A
M
M
D
A
G
V
P
L
V
R
P
V
S
G
I
A
M
G
L
I
L
E
Q
-------
D
-------
G
F
A
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
T
S
E
G
L
T
S
L
Q
M
D
I
K
I
A
G
I
T
P
A
I
M
E
Q
A
L
A
Q
A
K
E
G
R
A
H
I
L
G
E
M
N
K
A
M
D
A
P
R
A
D
V
G
D
F
A
P
K
I
E
T
I
N
I
P
T
D
K
I
R
E
V
I
G
S
G
G
K
V
I
R
E
I
V
A
T
T
G
A
K
V
D
I
N
D
D
G
V
V
K
V
S
A
S
D
G
A
K
I
K
A
A
I
D
-
W
I
K
S
I
T
D----------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
87.76
47%
-94
- C4 -
4AID
2
PNP_CAUCR
A:
[15-627]
M
F
D
I
K
R
K
T
I
E
W
G
G
K
T
L
V
L
E
T
G
R
I
A
R
Q
A
D
G
A
V
L
A
T
M
G
E
T
V
V
L
A
T
A
V
-
F
A
K
S
-
Q
K
P
G
Q
D
F
F
P
L
T
V
N
Y
Q
E
K
T
F
A
A
G
K
I
P
G
G
F
F
K
R
E
G
R
P
S
E
K
E
T
L
V
S
R
L
I
D
R
P
I
R
P
L
F
V
K
G
F
K
N
E
V
Q
V
V
V
T
V
L
Q
H
D
L
E
N
D
P
D
I
L
G
M
V
A
A
S
A
A
L
C
L
S
G
A
P
F
M
G
P
I
G
A
A
R
V
G
W
V
D
G
A
--
Y
V
L
N
P
T
L
D
E
M
K
E
S
K
M
D
L
V
V
A
G
-
T
A
-
D
A
-
V
M
M
V
E
S
E
I
Q
E
L
S
E
E
I
V
L
G
G
V
N
F
A
H
Q
Q
M
----
Q
A
V
I
D
A
I
I
D
L
A
E
H
A
A
K
-
E
P
F
A
F
E
P
E
D
--
T
D
A
I
KAK
M
K
D
--
L
--
V
G
-
A
D
--
I
A
A
A
Y
K
--
I
Q
K
-----
K
Q
D
-----
R
Y
E
A
V
G
A
A
K
K
K
A
I
------
A
A
L
GLSDE
N
P
--
T
--
G
Y
D
P
L
K
L
G
A
I
F
K
E
L
E
A
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V
R
R
G
I
L
D
T
G
L
R
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G
R
D
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K
T
V
R
P
I
L
G
E
V
G
I
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
I
V
V
A
T
L
G
T
G
D
----
D
----
E
----
Q
F
I
D
A
L
E
G
T
Y
K
E
S
F
L
L
H
Y
N
F
P
P
Y
S
V
G
E
T
G
R
M
G
S
P
G
R
R
E
I
G
H
G
K
L
A
W
R
A
L
R
P
M
L
P
T
K
E
D
F
P
Y
T
I
R
L
V
S
E
I
T
E
S
N
G
S
S
S
M
A
T
V
C
G
S
S
L
A
M
M
D
A
G
V
P
L
V
R
P
V
S
G
I
A
M
G
L
I
L
E
Q
-------
D
-------
G
F
A
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
T
S
E
G
L
T
S
L
Q
M
D
I
K
I
A
G
I
T
P
A
I
M
E
Q
A
L
A
Q
A
K
E
G
R
A
H
I
L
G
E
M
N
K
A
M
D
A
P
R
A
D
V
G
D
F
A
P
K
-------------------------------------------
S
A
S
D
G
A
K
I
K
A
A
I
D
-
W
----------------------------------------------------------------------------------------------------------------------------------------------------
140
HHSearch
84.87
39%
-96
- C4 -
3U1K
2
PNPT1_HUMAN
A:
[6-627]
----
S
A
V
A
V
D
L
G
N
R
K
L
E
I
S
S
G
K
L
A
R
F
A
D
G
S
A
V
V
Q
S
G
D
T
A
V
M
V
T
A
V
-
S
K
T
K
P
S
-
P
-
S
Q
F
M
P
L
V
V
D
Y
R
Q
K
A
A
A
A
G
R
I
P
T
N
Y
L
-----
T
S
D
K
E
I
L
T
S
R
I
I
D
R
S
I
R
P
L
F
P
A
G
Y
F
Y
D
T
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C
N
L
L
A
V
D
G
V
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D
V
L
A
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N
G
A
S
V
A
L
S
L
S
D
I
P
W
N
G
P
V
G
A
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R
I
G
-
I
I
-
D
G
E
Y
V
V
N
P
T
R
K
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M
S
S
S
T
L
N
L
V
V
A
G
-
A
P
K
S
Q
-
I
V
M
L
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S
A
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N
I
L
Q
Q
D
F
C
H
A
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K
V
G
V
K
Y
T
----
Q
Q
I
I
Q
G
I
Q
Q
L
V
K
E
T
G
V
T
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R
T
-
P
Q
K
L
F
TP
S
P
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---
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K
Y
--
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K
L
A
M
E
R
--
L
Y
A
V
F
T
DY
E
H
D
-----
K
V
S
-----
R
D
E
A
V
N
K
I
R
L
D
T
E
------
E
Q
L
-----
K
E
--
K
F
P
E
A
D
P
Y
E
I
I
E
S
F
N
V
V
A
K
E
V
F
R
S
I
V
L
N
E
Y
K
R
C
D
G
R
D
L
T
S
L
R
N
V
S
C
E
V
D
M
F
K
T
L
H
G
S
A
L
F
Q
R
G
Q
T
Q
V
L
C
T
V
T
F
D
S
L
E
----
S
----
G
I
KSD
Q
V
I
T
A
I
N
G
I
K
D
K
N
F
M
L
H
Y
E
F
P
P
Y
A
T
N
E
I
G
K
V
T
G
L
N
R
R
E
L
G
H
G
A
L
A
E
K
A
L
Y
P
V
I
P
R
--
D
F
P
F
T
I
R
V
T
S
E
V
L
E
S
N
G
S
S
S
M
A
S
A
C
G
G
S
L
A
L
M
D
S
G
V
P
I
S
S
A
V
A
G
V
A
I
G
L
V
T
K
T
D
PEKGEI
E
-------
D
Y
R
L
L
T
D
I
L
G
I
E
D
Y
N
G
D
M
D
F
K
I
A
G
T
N
K
G
I
T
A
L
Q
A
D
I
K
L
P
G
I
P
I
K
I
V
M
E
A
I
Q
Q
A
S
V
A
K
K
E
I
L
Q
I
M
N
K
T
I
S
K
P
R
A
S
R
K
E
N
G
P
V
V
E
T
V
Q
V
P
L
S
K
R
A
K
F
V
G
P
G
G
Y
N
L
K
K
L
Q
A
E
T
G
V
T
I
S
Q
V
D
E
E
T
F
S
V
F
A
P
T
P
S
A
M
H
E
A
R
D
F
I
T
E
--------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
84.11
44%
-89
- C4 -
4NBQ
3
PNP_COXBU
C:
[23-638]
----
I
R
K
T
F
Q
Y
G
K
H
E
V
T
F
E
T
G
E
-
A
R
Q
A
T
G
A
V
V
V
R
-
G
D
T
V
L
L
V
S
V
V
-
A
K
K
E
A
E
---
R
D
F
F
P
L
T
V
N
Y
Q
E
K
T
Y
A
A
G
K
I
P
G
G
Y
F
K
R
E
G
R
P
T
E
K
E
T
L
T
S
R
L
I
D
R
P
L
R
P
L
F
P
K
G
F
T
N
E
V
Q
V
I
A
T
V
L
S
V
D
S
K
V
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T
D
I
P
A
I
L
G
A
S
A
A
I
G
L
S
G
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P
F
N
G
S
L
G
A
A
R
V
G
-
Y
R
G
-
G
E
Y
L
L
N
P
S
L
D
E
L
K
D
S
A
L
D
L
V
V
A
G
-
T
--
R
D
-
A
V
L
V
E
S
E
A
Q
E
L
P
-
E
S
V
L
G
A
V
L
H
G
H
Q
-
A
----
Q
V
A
I
Q
A
I
A
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I
Q
E
A
G
G
-
A
K
W
E
W
E
P
P
T
--
V
N
T
A
---
L
E
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W
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V
E
K
S
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-
A
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--
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K
A
Y
Q
--
I
Q
E
-----
K
T
A
-----
R
Q
A
Q
I
Q
A
I
R
D
Q
L
L
A
D
RAAE------------------
E
H
E
L
A
V
I
F
H
E
L
E
R
R
I
V
R
E
Q
I
L
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T
Q
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V
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T
L
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T
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----
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V
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N
G
S
S
S
A
S
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C
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-
S
S
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A
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A
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G
L
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K
I
E
G
I
T
K
E
I
-
E
Q
A
L
D
Q
A
K
E
G
R
L
H
I
L
-
S
I
N
K
V
L
D
K
P
R
S
Q
V
S
D
L
A
P
Q
Y
V
T
-
K
I
N
P
E
K
I
R
D
V
I
G
K
G
G
V
V
I
R
E
I
T
E
A
T
N
C
A
I
D
I
S
D
D
G
T
I
K
I
A
A
H
T
T
E
E
G
E
A
A
K
R
R
I
E
E
L
T
------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
84.01
47%
-94
- C4 -
4AID
2
PNP_CAUCR
B:
[15-570]
M
F
D
I
K
R
K
T
I
E
W
G
G
K
T
L
V
L
E
T
G
R
I
A
R
Q
A
D
G
A
V
L
A
T
M
G
E
T
V
V
L
A
T
A
V
-
F
A
K
S
-
Q
K
P
G
Q
D
F
F
P
L
T
V
N
Y
Q
E
K
T
F
A
A
G
K
I
P
G
G
F
F
K
R
E
G
R
P
S
E
K
E
T
L
V
S
R
L
I
D
R
P
I
R
P
L
F
V
K
G
F
K
N
E
V
Q
V
V
V
T
V
L
Q
H
D
L
E
N
D
P
D
I
L
G
M
V
A
A
S
A
A
L
C
L
S
G
A
P
F
M
G
P
I
G
A
A
R
V
G
W
V
D
G
A
--
Y
V
L
N
P
T
L
D
E
M
K
E
S
K
M
D
L
V
V
A
G
-
T
A
-
D
A
-
V
M
M
V
E
S
E
I
Q
E
L
S
E
E
I
V
L
G
G
V
N
F
A
H
Q
Q
M
----
Q
A
V
I
D
A
I
I
D
L
A
E
H
A
A
K
-
E
P
F
A
F
E
P
E
D
--
T
D
A
I
K
A
K
M
K
D
--
L
--
V
G
-
A
D
--
I
A
A
A
Y
K
--
I
Q
K
-----
K
Q
D
-----
R
Y
E
A
V
G
A
A
K
K
K
A
I
------
A
A
L
GLSDE
N
P
--
T
--
G
Y
D
P
L
K
L
G
A
I
F
K
E
L
E
A
D
V
V
R
R
G
I
L
D
T
G
L
R
I
D
G
R
D
V
K
T
V
R
P
I
L
G
E
V
G
I
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
I
V
V
A
T
L
G
T
G
D
----
D
----
E
----
Q
F
I
D
A
L
E
G
T
Y
K
E
S
F
L
L
H
Y
N
F
P
P
Y
S
V
G
E
T
G
R
M
G
S
P
G
R
R
E
I
G
H
G
K
L
A
W
R
A
L
R
P
M
L
P
T
K
E
D
F
P
Y
T
I
R
L
V
S
E
I
T
E
S
N
G
S
S
S
M
A
T
V
C
G
S
S
L
A
M
M
D
A
G
V
P
L
V
R
P
V
S
G
I
A
M
G
L
I
L
E
Q
-------
D
-------
G
F
A
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
T
S
E
G
L
T
S
L
Q
M
D
I
K
I
A
G
I
T
P
A
I
M
E
Q
A
L
A
Q
A
K
E
G
R
A
H
I
L
G
E
M
N
K
A
M
D
A
P
R
A
D
V
G
D
F
A
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
Fugue
83.98
38%
-90
- C4 -
3U1K
2
PNPT1_HUMAN
A:
[4-627]
--
M
A
S
A
V
A
V
D
L
G
N
R
K
L
E
I
S
S
G
K
L
A
R
F
A
D
G
S
A
V
V
Q
S
G
D
T
A
V
M
V
T
A
V
-
S
K
T
K
-
P
S
P
-
S
Q
F
M
P
L
V
V
D
Y
R
Q
K
A
A
A
A
G
R
I
P
T
N
Y
L
T
-----
S
D
K
E
I
L
T
S
R
I
I
D
R
S
I
R
P
L
F
P
A
G
Y
F
Y
D
T
Q
V
L
C
N
L
L
A
V
D
G
V
N
E
P
D
V
L
A
I
N
G
A
S
V
A
L
S
L
S
D
I
P
W
N
G
P
V
G
A
V
R
I
G
-
I
I
-
D
G
E
Y
V
V
N
P
T
R
K
E
M
S
S
S
T
L
N
L
V
V
A
G
A
P
K
-
S
Q
-
I
V
M
L
E
A
S
A
E
N
I
L
Q
Q
D
F
C
H
A
I
K
V
G
V
K
Y
T
----
Q
Q
I
I
Q
G
I
Q
Q
L
V
K
E
T
G
V
-
T
K
R
T
P
Q
K
L
F
--
T
P
S
P
---
E
I
V
--
K
Y
T
H
K
-
L
A
--
M
E
R
L
Y
A
--
V
F
T
DYEHD
K
V
S
-----
R
D
E
A
V
N
K
I
R
L
D
T
E
------
E
Q
L
-----
K
E
--
K
F
P
E
A
D
P
Y
E
I
I
E
S
F
N
V
V
A
K
E
V
F
R
S
I
V
L
N
E
Y
K
R
C
D
G
R
D
L
T
S
L
R
N
V
S
C
E
V
D
M
F
K
T
L
H
G
S
A
L
F
Q
R
G
Q
T
Q
V
L
C
T
V
T
F
D
S
L
E
----
S
G
I
KS
D
----
Q
V
I
T
A
I
N
G
I
K
D
K
N
F
M
L
H
Y
E
F
P
P
Y
A
T
N
E
I
G
K
V
T
G
L
N
R
R
E
L
G
H
G
A
L
A
E
K
A
L
Y
P
V
I
P
R
--
D
F
P
F
T
I
R
V
T
S
E
V
L
E
S
N
G
S
S
S
M
A
S
A
C
G
G
S
L
A
L
M
D
S
G
V
P
I
S
S
A
V
A
G
V
A
I
G
L
V
T
K
T
-------
D
PEKGEIE
D
Y
R
L
L
T
D
I
L
G
I
E
D
Y
N
G
D
M
D
F
K
I
A
G
T
N
K
G
I
T
A
L
Q
A
D
I
K
L
P
G
I
P
I
K
I
V
M
E
A
I
Q
Q
A
S
V
A
K
K
E
I
L
Q
I
M
N
K
T
I
S
K
P
R
A
S
R
K
E
N
G
P
V
V
E
T
V
Q
V
P
L
S
K
R
A
K
F
V
G
P
G
G
Y
N
L
K
K
L
Q
A
E
T
G
V
T
I
S
Q
V
D
E
E
T
F
S
V
F
A
P
T
P
S
A
M
H
E
A
R
D
F
I
T
E
--------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
83.21
47%
-90
- C4 -
3GCM
7
PNP_ECOLI
C:
[1-544]
M
L
N
P
I
V
R
K
F
Q
Y
G
Q
H
T
V
T
L
E
T
G
M
M
A
R
Q
A
T
A
A
V
M
V
S
M
D
D
T
A
V
F
V
T
V
V
G
Q
K
K
A
-
K
P
G
-
Q
D
F
F
P
L
T
V
N
Y
Q
E
R
T
Y
A
A
G
R
I
P
G
S
F
F
R
R
E
G
R
P
S
E
G
E
T
L
I
A
R
L
I
D
R
P
I
R
P
L
F
P
E
G
F
V
N
E
V
Q
V
I
A
T
V
V
S
V
N
P
Q
V
N
P
D
I
V
A
M
I
G
A
S
A
A
L
S
L
S
G
I
P
F
N
G
P
I
G
A
A
R
V
G
-
Y
I
-
N
D
Q
Y
V
L
N
P
T
Q
D
E
L
K
E
S
K
L
D
L
V
V
A
G
-
T
E
-
A
A
-
V
L
M
V
E
S
E
A
E
L
L
S
E
D
Q
M
L
G
A
V
V
F
G
H
E
Q
Q
----
Q
V
V
I
Q
N
I
N
E
L
V
K
E
A
G
K
-
P
R
W
D
W
Q
P
E
P
--
V
N
E
A
---
L
N
A
--
R
V
A
A
L
-
A
E
AR
L
S
D
A
Y
R
--
I
T
D
-----
K
Q
E
-----
R
Y
A
Q
V
D
V
I
K
S
E
T
I
------
A
T
L
LA---
E
D
--
E
--
T
L
D
E
N
E
L
G
E
I
L
H
A
I
E
K
N
V
V
R
S
R
V
L
A
G
E
P
R
I
D
G
R
E
K
D
M
I
R
G
L
D
V
R
T
G
V
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
L
V
T
A
T
L
G
T
A
R
----
D
----
A
----
Q
V
L
D
E
L
M
G
E
R
T
D
T
F
L
F
H
Y
N
F
P
P
Y
S
V
G
E
T
G
M
V
G
S
P
K
R
R
E
I
G
H
G
R
L
A
K
R
G
V
L
A
V
M
P
D
M
D
K
F
P
Y
T
V
R
V
V
S
E
I
T
E
S
N
G
S
S
S
M
A
S
V
C
G
A
S
L
A
L
M
D
A
G
V
P
I
K
A
A
V
A
G
I
A
M
G
L
V
K
E
G
-------
D
-------
N
Y
V
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
S
R
D
G
I
S
A
L
Q
M
D
I
K
I
E
G
I
T
K
E
I
M
Q
V
A
L
N
Q
A
K
G
A
R
L
H
I
L
G
V
M
E
Q
A
I
N
A
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
83.20
38%
-93
- C4 -
3U1K
2
PNPT1_HUMAN
C:
[9-628]
-------
A
V
D
L
G
N
R
K
L
E
I
S
S
G
K
L
A
R
F
A
D
G
S
A
V
V
Q
S
G
D
T
A
V
M
V
T
A
V
-
S
K
T
K
-
P
S
P
-
S
Q
F
M
P
L
V
V
D
Y
R
Q
K
A
A
A
A
G
R
I
P
T
N
Y
L
R
---
G
T
S
D
K
E
I
L
T
S
R
I
I
D
R
S
I
R
P
L
F
P
A
G
Y
F
Y
D
T
Q
V
L
C
N
L
L
A
V
D
G
V
N
E
P
D
V
L
A
I
N
G
A
S
V
A
L
S
L
S
D
I
P
W
N
G
P
V
G
A
V
R
I
G
I
I
D
G
--
E
Y
V
V
N
P
T
R
K
E
M
S
S
S
T
L
N
L
V
V
A
G
-
A
P
-
K
S
Q
I
V
M
L
E
A
S
A
E
N
I
L
Q
Q
D
F
C
H
A
I
K
V
G
V
K
Y
T
Q
Q
I
I
Q
G
I
Q
Q
L
V
K
E
T
G
V
T
K
R
T
-
P
Q
K
L
F
T
P
----
S
P
E
I
---
V
K
----
Y
T
H
K
-
L
A
--
M
E
R
L
Y
A
--
V
F
T
-----
D
Y
E
HD
K
V
S
R
D
E
A
V
N
K
I
R
L
D
T
E
------
E
Q
L
-----
K
E
K
F
P
--
E
A
D
P
Y
E
I
I
E
S
F
N
V
V
A
K
E
V
F
R
S
I
V
L
N
E
Y
K
R
C
D
G
R
D
L
T
S
L
R
N
V
S
C
E
V
D
M
F
K
T
L
H
G
S
A
L
F
Q
R
G
Q
T
Q
V
L
C
T
V
T
F
D
S
L
E
S
G
I
K
S
----
D
----
Q
V
I
T
A
I
N
G
I
K
D
K
N
F
M
L
H
Y
E
F
P
P
Y
A
T
N
E
I
G
K
V
T
G
L
N
R
R
E
L
G
H
G
A
L
A
E
K
A
L
Y
P
V
I
P
--
R
D
F
P
F
T
I
R
V
T
S
E
V
L
E
S
N
G
S
S
S
M
A
S
A
C
G
G
S
L
A
L
M
D
S
G
V
P
I
S
S
A
V
A
G
V
A
I
G
L
V
T
K
T
-------
D
GEIE---
D
Y
R
L
L
T
D
I
L
G
I
E
D
Y
N
G
D
M
D
F
K
I
A
G
T
N
K
G
I
T
A
L
Q
A
D
I
K
L
P
G
I
P
I
K
I
V
M
E
A
I
Q
Q
A
S
V
A
K
K
E
I
L
Q
I
M
N
K
T
I
S
K
P
R
A
S
R
K
E
N
G
P
V
V
E
T
V
Q
V
P
L
S
K
R
A
K
F
V
G
P
G
G
Y
N
L
K
K
L
Q
A
E
T
G
V
T
I
S
Q
V
D
E
E
T
F
S
V
F
A
P
T
P
S
A
M
H
E
A
R
----
D
F
I
T
-
E
I
C
-------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
83.12
38%
-94
- C4 -
3U1K
2
PNPT1_HUMAN
A:
[9-627]
-------
A
V
D
L
G
N
R
K
L
E
I
S
S
G
K
L
A
R
F
A
D
G
S
A
V
V
Q
S
G
D
T
A
V
M
V
T
A
V
-
S
K
T
K
-
P
S
P
-
S
Q
F
M
P
L
V
V
D
Y
R
Q
K
A
A
A
A
G
R
I
P
T
N
Y
L
-----
T
S
D
K
E
I
L
T
S
R
I
I
D
R
S
I
R
P
L
F
P
A
G
Y
F
Y
D
T
Q
V
L
C
N
L
L
A
V
D
G
V
N
E
P
D
V
L
A
I
N
G
A
S
V
A
L
S
L
S
D
I
P
W
N
G
P
V
G
A
V
R
I
G
I
I
D
G
--
E
Y
V
V
N
P
T
R
K
E
M
S
S
S
T
L
N
L
V
V
A
G
-
A
P
-
K
S
Q
I
V
M
L
E
A
S
A
E
N
I
L
Q
Q
D
F
C
H
A
I
K
V
G
V
K
Y
T
Q
Q
I
I
Q
G
I
Q
Q
L
V
K
E
T
G
V
T
K
R
T
-
P
Q
K
L
F
T
P
----
S
P
E
I
---
V
K
----
Y
T
H
K
-
L
A
--
M
E
R
L
Y
A
--
V
F
T
-----
D
Y
E
HD
K
V
S
R
D
E
A
V
N
K
I
R
L
D
T
E
------
E
Q
L
-----
K
E
K
F
P
--
E
A
D
P
Y
E
I
I
E
S
F
N
V
V
A
K
E
V
F
R
S
I
V
L
N
E
Y
K
R
C
D
G
R
D
L
T
S
L
R
N
V
S
C
E
V
D
M
F
K
T
L
H
G
S
A
L
F
Q
R
G
Q
T
Q
V
L
C
T
V
T
F
D
S
L
E
S
G
I
K
S
----
D
----
Q
V
I
T
A
I
N
G
I
K
D
K
N
F
M
L
H
Y
E
F
P
P
Y
A
T
N
E
I
G
K
V
T
G
L
N
R
R
E
L
G
H
G
A
L
A
E
K
A
L
Y
P
V
I
P
--
R
D
F
P
F
T
I
R
V
T
S
E
V
L
E
S
N
G
S
S
S
M
A
S
A
C
G
G
S
L
A
L
M
D
S
G
V
P
I
S
S
A
V
A
G
V
A
I
G
L
V
T
K
T
-------
D
PEKGEIE
D
Y
R
L
L
T
D
I
L
G
I
E
D
Y
N
G
D
M
D
F
K
I
A
G
T
N
K
G
I
T
A
L
Q
A
D
I
K
L
P
G
I
P
I
K
I
V
M
E
A
I
Q
Q
A
S
V
A
K
K
E
I
L
Q
I
M
N
K
T
I
S
K
P
R
A
S
R
K
E
N
G
P
V
V
E
T
V
Q
V
P
L
S
K
R
A
K
F
V
G
P
G
G
Y
N
L
K
K
L
Q
A
E
T
G
V
T
I
S
Q
V
D
E
E
T
F
S
V
F
A
P
T
P
S
A
M
H
E
A
R
----
D
F
I
T
-
E
---------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
82.79
47%
-94
- C4 -
4AID
2
PNP_CAUCR
C:
[15-569]
M
F
D
I
K
R
K
T
I
E
W
G
G
K
T
L
V
L
E
T
G
R
I
A
R
Q
A
D
G
A
V
L
A
T
M
G
E
T
V
V
L
A
T
A
V
-
F
A
K
S
-
Q
K
P
G
Q
D
F
F
P
L
T
V
N
Y
Q
E
K
T
F
A
A
G
K
I
P
G
G
F
F
K
R
E
G
R
P
S
E
K
E
T
L
V
S
R
L
I
D
R
P
I
R
P
L
F
V
K
G
F
K
N
E
V
Q
V
V
V
T
V
L
Q
H
D
L
E
N
D
P
D
I
L
G
M
V
A
A
S
A
A
L
C
L
S
G
A
P
F
M
G
P
I
G
A
A
R
V
G
W
V
D
G
A
--
Y
V
L
N
P
T
L
D
E
M
K
E
S
K
M
D
L
V
V
A
G
-
T
A
-
D
A
-
V
M
M
V
E
S
E
I
Q
E
L
S
E
E
I
V
L
G
G
V
N
F
A
H
Q
Q
M
----
Q
A
V
I
D
A
I
I
D
L
A
E
H
A
A
K
-
E
P
F
A
F
E
P
E
D
--
T
D
A
I
K
A
K
M
K
D
--
L
--
V
G
-
A
D
--
I
A
A
A
Y
K
--
I
Q
K
-----
K
Q
D
-----
R
Y
E
A
V
G
A
A
K
K
K
A
I
------
A
----------------------
A
I
F
K
E
L
E
A
D
V
V
R
R
G
I
L
D
T
G
L
R
I
D
G
R
D
V
K
T
V
R
P
I
L
G
E
V
G
I
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
I
V
V
A
T
L
G
T
G
D
----
D
----
E
----
Q
F
I
D
A
L
E
G
T
Y
K
E
S
F
L
L
H
Y
N
F
P
P
Y
S
V
G
E
T
G
R
M
G
S
P
G
R
R
E
I
G
H
G
K
L
A
W
R
A
L
R
P
M
L
P
T
K
E
D
F
P
Y
T
I
R
L
V
S
E
I
T
E
S
N
G
S
S
S
M
A
T
V
C
G
S
S
L
A
M
M
D
A
G
V
P
L
V
R
P
V
S
G
I
A
M
G
L
I
L
E
Q
-------
D
-------
G
F
A
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
T
S
E
G
L
T
S
L
Q
M
D
I
K
I
A
G
I
T
P
A
I
M
E
Q
A
L
A
Q
A
K
E
G
R
A
H
I
L
G
E
M
N
K
A
M
D
A
P
R
A
D
V
G
D
F
A
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
82.76
47%
-88
- C4 -
3H1C
2
PNP_ECOLI
R:
[1-544]
M
L
N
P
I
V
R
K
F
Q
Y
G
Q
H
T
V
T
L
E
T
G
M
M
A
R
Q
A
T
A
A
V
M
V
S
M
D
D
T
A
V
F
V
T
V
V
G
Q
K
K
A
-
K
P
G
-
Q
D
F
F
P
L
T
V
N
Y
Q
E
R
T
Y
A
A
G
R
I
P
G
S
F
F
R
R
E
G
R
P
S
E
G
E
T
L
I
A
R
L
I
D
R
P
I
R
P
L
F
P
E
G
F
V
N
E
V
Q
V
I
A
T
V
V
S
V
N
P
Q
V
N
P
D
I
V
A
M
I
G
A
S
A
A
L
S
L
S
G
I
P
F
N
G
P
I
G
A
A
R
V
G
-
Y
I
-
N
D
Q
Y
V
L
N
P
T
Q
D
E
L
K
E
S
K
L
D
L
V
V
A
G
-
T
E
-
A
A
-
V
L
M
V
E
S
E
A
Q
L
L
S
E
D
Q
M
L
G
A
V
V
F
G
H
E
Q
Q
----
Q
V
V
I
Q
N
I
N
E
L
V
K
E
A
G
K
-
P
R
W
D
W
Q
P
E
P
--
V
N
E
A
---
L
N
A
--
R
V
A
A
L
-
A
E
AR
L
S
D
A
Y
R
--
I
T
D
-----
K
Q
E
-----
R
Y
A
Q
V
D
V
I
K
S
E
T
I
------
A
T
L
LA---
E
D
--
E
--
T
L
D
E
N
E
L
G
E
I
L
H
A
I
E
K
N
V
V
R
S
R
V
L
A
G
E
P
R
I
D
G
R
E
K
D
M
I
R
G
L
D
V
R
T
G
V
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
L
V
T
A
T
L
G
T
A
R
----
D
----
A
----
Q
V
L
D
E
L
M
G
E
R
T
D
T
F
L
F
H
Y
N
F
P
P
Y
S
V
G
E
T
G
M
V
G
S
P
K
R
R
E
I
G
H
G
R
L
A
K
R
G
V
L
A
V
M
P
D
M
D
K
F
P
Y
T
V
R
V
V
S
E
I
T
E
S
N
G
S
S
S
M
A
S
V
C
G
A
S
L
A
L
M
D
A
G
V
P
I
K
A
A
V
A
G
I
A
M
G
L
V
K
E
G
-------
D
-------
N
Y
V
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
S
R
D
G
I
S
A
L
Q
M
D
I
K
I
E
G
I
T
K
E
I
M
Q
V
A
L
N
Q
A
K
G
A
R
L
H
I
L
G
V
M
E
Q
A
I
N
A
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
82.70
38%
-90
- C4 -
3U1K
2
PNPT1_HUMAN
B:
[9-628]
-------
A
V
D
L
G
N
R
K
L
E
I
S
S
G
K
L
A
R
F
A
D
G
S
A
V
V
Q
S
G
D
T
A
V
M
V
T
A
V
-
S
K
T
K
-
P
S
P
-
S
Q
F
M
P
L
V
V
D
Y
R
Q
K
A
A
A
A
G
R
I
P
T
N
Y
L
----
G
T
S
D
K
E
I
L
T
S
R
I
I
D
R
S
I
R
P
L
F
P
A
G
Y
F
Y
D
T
Q
V
L
C
N
L
L
A
V
D
G
V
N
E
P
D
V
L
A
I
N
G
A
S
V
A
L
S
L
S
D
I
P
W
N
G
P
V
G
A
V
R
I
G
I
I
D
G
--
E
Y
V
V
N
P
T
R
K
E
M
S
S
S
T
L
N
L
V
V
A
G
-
A
P
-
K
S
Q
I
V
M
L
E
A
S
A
E
N
I
L
Q
Q
D
F
C
H
A
I
K
V
G
V
K
Y
T
Q
Q
I
I
Q
G
I
Q
Q
L
V
K
E
T
G
V
T
K
R
T
-
P
Q
K
L
F
T
P
----
S
P
E
I
---
V
K
----
Y
T
H
K
-
L
A
--
M
E
R
L
Y
A
--
V
F
T
-----
D
Y
E
HD
K
V
S
R
D
E
A
V
N
K
I
R
L
D
T
E
------
E
Q
L
-----
K
E
K
F
P
--
E
A
D
P
Y
E
I
I
E
S
F
N
V
V
A
K
E
V
F
R
S
I
V
L
N
E
Y
K
R
C
D
G
R
D
L
T
S
L
R
N
V
S
C
E
V
D
M
F
K
T
L
H
G
S
A
L
F
Q
R
G
Q
T
Q
V
L
C
T
V
T
F
D
S
L
E
SGI-----------
Q
V
I
T
A
I
N
G
I
K
D
K
N
F
M
L
H
Y
E
F
P
P
Y
A
T
N
E
I
G
K
V
T
G
L
N
R
R
E
L
G
H
G
A
L
A
E
K
A
L
Y
P
V
I
P
--
R
D
F
P
F
T
I
R
V
T
S
E
V
L
E
S
N
G
S
S
S
M
A
S
A
C
G
G
S
L
A
L
M
D
S
G
V
P
I
S
S
A
V
A
G
V
A
I
G
L
V
T
K
T
-------
D
PGEIE--
D
Y
R
L
L
T
D
I
L
G
I
E
D
Y
N
G
D
M
D
F
K
I
A
G
T
N
K
G
I
T
A
L
Q
A
D
I
K
L
P
G
I
P
I
K
I
V
M
E
A
I
Q
Q
A
S
V
A
K
K
E
I
L
Q
I
M
N
K
T
I
S
K
P
R
A
S
R
K
E
N
G
P
V
V
E
T
V
Q
V
P
L
S
K
R
A
K
F
V
G
P
G
G
Y
N
L
K
K
L
Q
A
E
T
G
V
T
I
S
Q
V
D
E
E
T
F
S
V
F
A
P
T
P
S
A
M
H
E
A
R
----
D
F
I
T
-
E
I
C
-------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
82.46
47%
-91
- C4 -
3GCM
9
PNP_ECOLI
B:
[1-544]
M
L
N
P
I
V
R
K
F
Q
Y
G
Q
H
T
V
T
L
E
T
G
M
M
A
R
Q
A
T
A
A
V
M
V
S
M
D
D
T
A
V
F
V
T
V
V
G
Q
K
K
A
-
K
P
G
-
Q
D
F
F
P
L
T
V
N
Y
Q
E
R
T
Y
A
A
G
R
I
P
G
S
F
F
R
R
E
G
R
P
S
E
G
E
T
L
I
A
R
L
I
D
R
P
I
R
P
L
F
P
E
G
F
V
N
E
V
Q
V
I
A
T
V
V
S
V
N
P
Q
V
N
P
D
I
V
A
M
I
G
A
S
A
A
L
S
L
S
G
I
P
F
N
G
P
I
G
A
A
R
V
G
-
Y
I
-
N
D
Q
Y
V
L
N
P
T
Q
D
E
L
K
E
S
K
L
D
L
V
V
A
G
-
T
E
-
A
A
-
V
L
M
V
E
S
E
A
E
L
L
S
E
D
Q
M
L
G
A
V
V
F
G
H
E
Q
Q
----
Q
V
V
I
Q
N
I
N
E
L
V
K
E
A
G
K
-
P
R
W
D
W
Q
P
E
P
--
V
N
E
A
---
L
N
A
--
R
V
A
A
L
-
A
E
A
R
L
S
D
A
Y
R
--
I
T
D
-----
K
Q
E
-----
R
Y
A
Q
V
D
V
I
K
S
E
T
I
------
A
T
L
L
A
---
E
D
--
E
--
T
L
D
E
N
E
L
G
E
I
L
H
A
I
E
K
N
V
V
R
S
R
V
L
A
G
E
P
R
I
D
G
R
E
K
D
M
I
R
G
L
D
V
R
T
G
V
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
L
V
T
A
T
L
G
T
A
R
----
D
----
A
----
Q
V
L
D
E
L
M
G
E
R
T
D
T
F
L
F
H
Y
N
F
P
P
Y
S
V
G
E
T
G
M
V
G
S
P
K
R
R
E
I
G
H
G
R
L
A
K
R
G
V
L
A
V
M
P
D
M
D
K
F
P
Y
T
V
R
V
V
S
E
I
T
E
S
N
G
S
S
S
M
A
S
V
C
G
A
S
L
A
L
M
D
A
G
V
P
I
K
A
A
V
A
G
I
A
M
G
L
V
K
E
G
-------
D
-------
N
Y
V
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
S
R
D
G
I
S
A
L
Q
M
D
I
K
I
E
G
I
T
K
E
I
M
Q
V
A
L
N
Q
A
K
G
A
R
L
H
I
L
G
V
M
E
Q
A
I
N
A
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
82.43
47%
-89
- C4 -
3GCM
6
PNP_ECOLI
A:
[2-545]
-
L
N
P
I
V
R
K
F
Q
Y
G
Q
H
T
V
T
L
E
T
G
M
M
A
R
Q
A
T
A
A
V
M
V
S
M
D
D
T
A
V
F
V
T
V
V
G
Q
K
K
A
-
K
P
G
-
Q
D
F
F
P
L
T
V
N
Y
Q
E
R
T
Y
A
A
G
R
I
P
G
S
F
F
R
R
E
G
R
P
S
E
G
E
T
L
I
A
R
L
I
D
R
P
I
R
P
L
F
P
E
G
F
V
N
E
V
Q
V
I
A
T
V
V
S
V
N
P
Q
V
N
P
D
I
V
A
M
I
G
A
S
A
A
L
S
L
S
G
I
P
F
N
G
P
I
G
A
A
R
V
G
-
Y
I
-
N
D
Q
Y
V
L
N
P
T
Q
D
E
L
K
E
S
K
L
D
L
V
V
A
G
-
T
E
-
A
A
-
V
L
M
V
E
S
E
A
E
L
L
S
E
D
Q
M
L
G
A
V
V
F
G
H
E
Q
Q
----
Q
V
V
I
Q
N
I
N
E
L
V
K
E
A
G
K
-
P
R
W
D
W
Q
P
E
P
--
V
N
E
A
---
L
N
A
--
R
V
A
A
L
-
A
E
A
R
L
S
D
A
Y
R
--
I
T
D
-----
K
Q
E
-----
R
Y
A
Q
V
D
V
I
K
S
E
T
I
------
A
T
L
L
A
---
E
D
--
E
--
T
L
D
E
N
E
L
G
E
I
L
H
A
I
E
K
N
V
V
R
S
R
V
L
A
G
E
P
R
I
D
G
R
E
K
D
M
I
R
G
L
D
V
R
T
G
V
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
L
V
T
A
T
L
G
T
A
R
----
D
----
A
----
Q
V
L
D
E
L
M
G
E
R
T
D
T
F
L
F
H
Y
N
F
P
P
Y
S
V
G
E
T
G
M
V
G
S
P
K
R
R
E
I
G
H
G
R
L
A
K
R
G
V
L
A
V
M
P
D
M
D
K
F
P
Y
T
V
R
V
V
S
E
I
T
E
S
N
G
S
S
S
M
A
S
V
C
G
A
S
L
A
L
M
D
A
G
V
P
I
K
A
A
V
A
G
I
A
M
G
L
V
K
E
G
-------
D
-------
N
Y
V
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
S
R
D
G
I
S
A
L
Q
M
D
I
K
I
E
G
I
T
K
E
I
M
Q
V
A
L
N
Q
A
K
G
A
R
L
H
I
L
G
V
M
E
Q
A
I
N
A
P
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
82.09
47%
-90
- C4 -
3H1C
2
PNP_ECOLI
O:
[1-544]
M
L
N
P
I
V
R
K
F
Q
Y
G
Q
H
T
V
T
L
E
T
G
M
M
A
R
Q
A
T
A
A
V
M
V
S
M
D
D
T
A
V
F
V
T
V
V
G
Q
K
K
A
-
K
P
G
-
Q
D
F
F
P
L
T
V
N
Y
Q
E
R
T
Y
A
A
G
R
I
P
G
S
F
F
R
R
E
G
R
P
S
E
G
E
T
L
I
A
R
L
I
D
R
P
I
R
P
L
F
P
E
G
F
V
N
E
V
Q
V
I
A
T
V
V
S
V
N
P
Q
V
N
P
D
I
V
A
M
I
G
A
S
A
A
L
S
L
S
G
I
P
F
N
G
P
I
G
A
A
R
V
G
-
Y
I
-
N
D
Q
Y
V
L
N
P
T
Q
D
E
L
K
E
S
K
L
D
L
V
V
A
G
-
T
E
-
A
A
-
V
L
M
V
E
S
E
A
Q
L
L
S
E
D
Q
M
L
G
A
V
V
F
G
H
E
Q
Q
----
Q
V
V
I
Q
N
I
N
E
L
V
K
E
A
G
K
-
P
R
W
D
W
Q
P
E
P
--
V
N
E
A
---
L
N
A
--
R
V
A
A
L
-
A
E
AR
L
S
D
A
Y
R
--
I
T
D
-----
K
Q
E
-----
R
Y
A
Q
V
D
V
I
K
S
E
T
I
------
A
T
L
LA---
E
D
--
E
--
T
L
D
E
N
E
L
G
E
I
L
H
A
I
E
K
N
V
V
R
S
R
V
L
A
G
E
P
R
I
D
G
R
E
K
D
M
I
R
G
L
D
V
R
T
G
V
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
L
V
T
A
T
L
G
T
A
R
----
D
----
A
----
Q
V
L
D
E
L
M
G
E
R
T
D
T
F
L
F
H
Y
N
F
P
P
Y
S
V
G
E
T
G
M
V
G
S
P
K
R
R
E
I
G
H
G
R
L
A
K
R
G
V
L
A
V
M
P
D
M
D
K
F
P
Y
T
V
R
V
V
S
E
I
T
E
S
N
G
S
S
S
M
A
S
V
C
G
A
S
L
A
L
M
D
A
G
V
P
I
K
A
A
V
A
G
I
A
M
G
L
V
K
E
G
-------
D
-------
N
Y
V
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
S
R
D
G
I
S
A
L
Q
M
D
I
K
I
E
G
I
T
K
E
I
M
Q
V
A
L
N
Q
A
K
G
A
R
L
H
I
L
G
V
M
E
Q
A
I
N
A
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
138
HHSearch
82.05
43%
-106
- C4 -
3CDI
-
PNP_ECOLI
A:
[25-565]
-
L
N
P
I
V
R
K
F
Q
Y
G
Q
H
T
V
T
L
E
T
G
M
M
A
R
Q
A
T
A
A
V
M
V
S
M
D
D
T
A
V
F
V
T
V
V
-
G
Q
K
K
A
K
P
G
-
Q
D
F
F
P
L
T
V
N
Y
Q
E
R
T
Y
A
A
G
R
I
P
-------
G
R
P
S
E
G
E
T
L
I
A
R
L
I
D
R
P
I
R
P
L
F
P
E
G
F
V
N
E
V
Q
V
I
A
T
V
V
S
V
N
P
Q
V
N
P
D
I
V
A
M
I
G
A
S
A
A
L
S
L
S
G
I
P
F
N
G
P
I
G
A
A
R
V
G
-
Y
I
-
N
D
Q
Y
V
L
N
P
T
Q
D
E
L
K
E
S
K
L
D
L
V
V
A
G
-
T
E
-
A
A
-
V
L
M
V
E
S
E
A
Q
L
L
S
E
D
Q
M
L
G
A
V
V
F
G
H
E
Q
Q
----
Q
V
V
I
Q
N
I
N
E
L
V
K
E
A
G
K
P
R
W
D
-
W
Q
P
E
P
V-
N
E
A
L
---
N
A
R
--
V
A
A
L
A
E
A
R
--
L
S
D
A
Y
R
--
I
T
D
-----
K
Q
E
-----
R
Y
A
Q
V
D
V
I
K
S
E
T
I
------
A
T
L
-----
L
A
--
E
DE
T
L
D
E
N
E
L
G
E
I
L
H
A
I
E
K
N
V
V
R
S
R
V
L
A
G
E
P
R
I
D
G
R
E
K
D
M
I
R
G
L
D
V
R
T
G
V
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
L
V
T
A
T
L
G
T
-------------------------
R
T
D
T
F
L
F
H
Y
N
F
P
P
Y
S
V
G
E
T
G
M
V
-----
R
E
I
G
H
G
R
L
A
K
R
G
V
L
A
V
M
P
D
M
D
K
F
P
Y
T
V
R
V
V
S
E
I
T
E
S
N
G
S
S
S
M
A
S
V
C
G
A
S
L
A
L
M
D
A
G
V
P
I
K
A
A
V
A
G
I
A
M
G
L
V
K
E
G
-------
D
-------
N
Y
V
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
S
R
D
G
I
S
A
L
Q
M
D
I
K
I
E
G
I
T
K
E
I
M
Q
V
A
L
N
Q
A
K
G
A
R
L
H
I
L
G
V
M
E
Q
A
I
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
82.02
47%
-89
- C4 -
3H1C
13
PNP_ECOLI
X:
[1-544]
M
L
N
P
I
V
R
K
F
Q
Y
G
Q
H
T
V
T
L
E
T
G
M
M
A
R
Q
A
T
A
A
V
M
V
S
M
D
D
T
A
V
F
V
T
V
V
G
Q
K
K
A
-
K
P
G
-
Q
D
F
F
P
L
T
V
N
Y
Q
E
R
T
Y
A
A
G
R
I
P
G
S
F
F
R
R
E
G
R
P
S
E
G
E
T
L
I
A
R
L
I
D
R
P
I
R
P
L
F
P
E
G
F
V
N
E
V
Q
V
I
A
T
V
V
S
V
N
P
Q
V
N
P
D
I
V
A
M
I
G
A
S
A
A
L
S
L
S
G
I
P
F
N
G
P
I
G
A
A
R
V
G
-
Y
I
-
N
D
Q
Y
V
L
N
P
T
Q
D
E
L
K
E
S
K
L
D
L
V
V
A
G
-
T
E
-
A
A
-
V
L
M
V
E
S
E
A
Q
L
L
S
E
D
Q
M
L
G
A
V
V
F
G
H
E
Q
Q
----
Q
V
V
I
Q
N
I
N
E
L
V
K
E
A
G
K
-
P
R
W
D
W
Q
P
E
P
--
V
N
E
A
---
L
N
A
--
R
V
A
A
L
-
A
E
AR
L
S
D
A
Y
R
--
I
T
D
-----
K
Q
E
-----
R
Y
A
Q
V
D
V
I
K
S
E
T
I
------
A
T
L
LA---
E
D
--
E
--
T
L
D
E
N
E
L
G
E
I
L
H
A
I
E
K
N
V
V
R
S
R
V
L
A
G
E
P
R
I
D
G
R
E
K
D
M
I
R
G
L
D
V
R
T
G
V
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
L
V
T
A
T
L
G
T
A
R
----
D
----
A
----
Q
V
L
D
E
L
M
G
E
R
T
D
T
F
L
F
H
Y
N
F
P
P
Y
S
V
G
E
T
G
M
V
G
S
P
K
R
R
E
I
G
H
G
R
L
A
K
R
G
V
L
A
V
M
P
D
M
D
K
F
P
Y
T
V
R
V
V
S
E
I
T
E
S
N
G
S
S
S
M
A
S
V
C
G
A
S
L
A
L
M
D
A
G
V
P
I
K
A
A
V
A
G
I
A
M
G
L
V
K
E
G
-------
D
-------
N
Y
V
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
S
R
D
G
I
S
A
L
Q
M
D
I
K
I
E
G
I
T
K
E
I
M
Q
V
A
L
N
Q
A
K
G
A
R
L
H
I
L
G
V
M
E
Q
A
I
N
A
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
82.02
47%
-89
- C4 -
3H1C
4
PNP_ECOLI
A:
[1-544]
M
L
N
P
I
V
R
K
F
Q
Y
G
Q
H
T
V
T
L
E
T
G
M
M
A
R
Q
A
T
A
A
V
M
V
S
M
D
D
T
A
V
F
V
T
V
V
G
Q
K
K
A
-
K
P
G
-
Q
D
F
F
P
L
T
V
N
Y
Q
E
R
T
Y
A
A
G
R
I
P
G
S
F
F
R
R
E
G
R
P
S
E
G
E
T
L
I
A
R
L
I
D
R
P
I
R
P
L
F
P
E
G
F
V
N
E
V
Q
V
I
A
T
V
V
S
V
N
P
Q
V
N
P
D
I
V
A
M
I
G
A
S
A
A
L
S
L
S
G
I
P
F
N
G
P
I
G
A
A
R
V
G
-
Y
I
-
N
D
Q
Y
V
L
N
P
T
Q
D
E
L
K
E
S
K
L
D
L
V
V
A
G
-
T
E
-
A
A
-
V
L
M
V
E
S
E
A
Q
L
L
S
E
D
Q
M
L
G
A
V
V
F
G
H
E
Q
Q
----
Q
V
V
I
Q
N
I
N
E
L
V
K
E
A
G
K
-
P
R
W
D
W
Q
P
E
P
--
V
N
E
A
---
L
N
A
--
R
V
A
A
L
-
A
E
A
R
L
S
D
A
Y
R
--
I
T
D
-----
K
Q
E
-----
R
Y
A
Q
V
D
V
I
K
S
E
T
I
------
A
T
L
L
A
---
E
D
--
E
--
T
L
D
E
N
E
L
G
E
I
L
H
A
I
E
K
N
V
V
R
S
R
V
L
A
G
E
P
R
I
D
G
R
E
K
D
M
I
R
G
L
D
V
R
T
G
V
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
L
V
T
A
T
L
G
T
A
R
----
D
----
A
----
Q
V
L
D
E
L
M
G
E
R
T
D
T
F
L
F
H
Y
N
F
P
P
Y
S
V
G
E
T
G
M
V
G
S
P
K
R
R
E
I
G
H
G
R
L
A
K
R
G
V
L
A
V
M
P
D
M
D
K
F
P
Y
T
V
R
V
V
S
E
I
T
E
S
N
G
S
S
S
M
A
S
V
C
G
A
S
L
A
L
M
D
A
G
V
P
I
K
A
A
V
A
G
I
A
M
G
L
V
K
E
G
-------
D
-------
N
Y
V
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
S
R
D
G
I
S
A
L
Q
M
D
I
K
I
E
G
I
T
K
E
I
M
Q
V
A
L
N
Q
A
K
G
A
R
L
H
I
L
G
V
M
E
Q
A
I
N
A
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
81.81
47%
-91
- C4 -
3H1C
2
PNP_ECOLI
B:
[1-544]
M
L
N
P
I
V
R
K
F
Q
Y
G
Q
H
T
V
T
L
E
T
G
M
M
A
R
Q
A
T
A
A
V
M
V
S
M
D
D
T
A
V
F
V
T
V
V
G
Q
K
K
A
-
K
P
G
-
Q
D
F
F
P
L
T
V
N
Y
Q
E
R
T
Y
A
A
G
R
I
P
G
S
F
F
R
R
E
G
R
P
S
E
G
E
T
L
I
A
R
L
I
D
R
P
I
R
P
L
F
P
E
G
F
V
N
E
V
Q
V
I
A
T
V
V
S
V
N
P
Q
V
N
P
D
I
V
A
M
I
G
A
S
A
A
L
S
L
S
G
I
P
F
N
G
P
I
G
A
A
R
V
G
-
Y
I
-
N
D
Q
Y
V
L
N
P
T
Q
D
E
L
K
E
S
K
L
D
L
V
V
A
G
-
T
E
-
A
A
-
V
L
M
V
E
S
E
A
Q
L
L
S
E
D
Q
M
L
G
A
V
V
F
G
H
E
Q
Q
----
Q
V
V
I
Q
N
I
N
E
L
V
K
E
A
G
K
-
P
R
W
D
W
Q
P
E
P
--
V
N
E
A
---
L
N
A
--
R
V
A
A
L
-
A
E
AR
L
S
D
A
Y
R
--
I
T
D
-----
K
Q
E
-----
R
Y
A
Q
V
D
V
I
K
S
E
T
I
------
A
T
L
LA---
E
D
--
E
--
T
L
D
E
N
E
L
G
E
I
L
H
A
I
E
K
N
V
V
R
S
R
V
L
A
G
E
P
R
I
D
G
R
E
K
D
M
I
R
G
L
D
V
R
T
G
V
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
L
V
T
A
T
L
G
T
A
R
----
D
----
A
----
Q
V
L
D
E
L
M
G
E
R
T
D
T
F
L
F
H
Y
N
F
P
P
Y
S
V
G
E
T
G
M
V
G
S
P
K
R
R
E
I
G
H
G
R
L
A
K
R
G
V
L
A
V
M
P
D
M
D
K
F
P
Y
T
V
R
V
V
S
E
I
T
E
S
N
G
S
S
S
M
A
S
V
C
G
A
S
L
A
L
M
D
A
G
V
P
I
K
A
A
V
A
G
I
A
M
G
L
V
K
E
G
-------
D
-------
N
Y
V
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
S
R
D
G
I
S
A
L
Q
M
D
I
K
I
E
G
I
T
K
E
I
M
Q
V
A
L
N
Q
A
K
G
A
R
L
H
I
L
G
V
M
E
Q
A
I
N
A
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
81.75
47%
-90
- C4 -
3H1C
2
PNP_ECOLI
V:
[1-544]
M
L
N
P
I
V
R
K
F
Q
Y
G
Q
H
T
V
T
L
E
T
G
M
M
A
R
Q
A
T
A
A
V
M
V
S
M
D
D
T
A
V
F
V
T
V
V
G
Q
K
K
A
-
K
P
G
-
Q
D
F
F
P
L
T
V
N
Y
Q
E
R
T
Y
A
A
G
R
I
P
G
S
F
F
R
R
E
G
R
P
S
E
G
E
T
L
I
A
R
L
I
D
R
P
I
R
P
L
F
P
E
G
F
V
N
E
V
Q
V
I
A
T
V
V
S
V
N
P
Q
V
N
P
D
I
V
A
M
I
G
A
S
A
A
L
S
L
S
G
I
P
F
N
G
P
I
G
A
A
R
V
G
-
Y
I
-
N
D
Q
Y
V
L
N
P
T
Q
D
E
L
K
E
S
K
L
D
L
V
V
A
G
-
T
E
-
A
A
-
V
L
M
V
E
S
E
A
Q
L
L
S
E
D
Q
M
L
G
A
V
V
F
G
H
E
Q
Q
----
Q
V
V
I
Q
N
I
N
E
L
V
K
E
A
G
K
-
P
R
W
D
W
Q
P
E
P
--
V
N
E
A
---
L
N
A
--
R
V
A
A
L
-
A
E
AR
L
S
D
A
Y
R
--
I
T
D
-----
K
Q
E
-----
R
Y
A
Q
V
D
V
I
K
S
E
T
I
------
A
T
L
LA---
E
D
--
E
--
T
L
D
E
N
E
L
G
E
I
L
H
A
I
E
K
N
V
V
R
S
R
V
L
A
G
E
P
R
I
D
G
R
E
K
D
M
I
R
G
L
D
V
R
T
G
V
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
L
V
T
A
T
L
G
T
A
R
----
D
----
A
----
Q
V
L
D
E
L
M
G
E
R
T
D
T
F
L
F
H
Y
N
F
P
P
Y
S
V
G
E
T
G
M
V
G
S
P
K
R
R
E
I
G
H
G
R
L
A
K
R
G
V
L
A
V
M
P
D
M
D
K
F
P
Y
T
V
R
V
V
S
E
I
T
E
S
N
G
S
S
S
M
A
S
V
C
G
A
S
L
A
L
M
D
A
G
V
P
I
K
A
A
V
A
G
I
A
M
G
L
V
K
E
G
-------
D
-------
N
Y
V
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
S
R
D
G
I
S
A
L
Q
M
D
I
K
I
E
G
I
T
K
E
I
M
Q
V
A
L
N
Q
A
K
G
A
R
L
H
I
L
G
V
M
E
Q
A
I
N
A
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
81.72
47%
-87
- C4 -
3H1C
2
PNP_ECOLI
I:
[2-544]
-
L
N
P
I
V
R
K
F
Q
Y
G
Q
H
T
V
T
L
E
T
G
M
M
A
R
Q
A
T
A
A
V
M
V
S
M
D
D
T
A
V
F
V
T
V
V
G
Q
K
K
A
-
K
P
G
-
Q
D
F
F
P
L
T
V
N
Y
Q
E
R
T
Y
A
A
G
R
I
P
G
S
F
F
R
R
E
G
R
P
S
E
G
E
T
L
I
A
R
L
I
D
R
P
I
R
P
L
F
P
E
G
F
V
N
E
V
Q
V
I
A
T
V
V
S
V
N
P
Q
V
N
P
D
I
V
A
M
I
G
A
S
A
A
L
S
L
S
G
I
P
F
N
G
P
I
G
A
A
R
V
G
-
Y
I
-
N
D
Q
Y
V
L
N
P
T
Q
D
E
L
K
E
S
K
L
D
L
V
V
A
G
-
T
E
-
A
A
-
V
L
M
V
E
S
E
A
Q
L
L
S
E
D
Q
M
L
G
A
V
V
F
G
H
E
Q
Q
----
Q
V
V
I
Q
N
I
N
E
L
V
K
E
A
G
K
-
P
R
W
D
W
Q
P
E
P
--
V
N
E
A
---
L
N
A
--
R
V
A
A
L
-
A
E
AR
L
S
D
A
Y
R
--
I
T
D
-----
K
Q
E
-----
R
Y
A
Q
V
D
V
I
K
S
E
T
I
------
A
T
L
LA---
E
D
--
E
--
T
L
D
E
N
E
L
G
E
I
L
H
A
I
E
K
N
V
V
R
S
R
V
L
A
G
E
P
R
I
D
G
R
E
K
D
M
I
R
G
L
D
V
R
T
G
V
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
L
V
T
A
T
L
G
T
A
R
----
D
----
A
----
Q
V
L
D
E
L
M
G
E
R
T
D
T
F
L
F
H
Y
N
F
P
P
Y
S
V
G
E
T
G
M
V
G
S
P
K
R
R
E
I
G
H
G
R
L
A
K
R
G
V
L
A
V
M
P
D
M
D
K
F
P
Y
T
V
R
V
V
S
E
I
T
E
S
N
G
S
S
S
M
A
S
V
C
G
A
S
L
A
L
M
D
A
G
V
P
I
K
A
A
V
A
G
I
A
M
G
L
V
K
E
G
-------
D
-------
N
Y
V
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
S
R
D
G
I
S
A
L
Q
M
D
I
K
I
E
G
I
T
K
E
I
M
Q
V
A
L
N
Q
A
K
G
A
R
L
H
I
L
G
V
M
E
Q
A
I
N
A
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
81.55
47%
-91
- C4 -
3H1C
3
PNP_ECOLI
K:
[1-544]
M
L
N
P
I
V
R
K
F
Q
Y
G
Q
H
T
V
T
L
E
T
G
M
M
A
R
Q
A
T
A
A
V
M
V
S
M
D
D
T
A
V
F
V
T
V
V
G
Q
K
K
A
-
K
P
G
-
Q
D
F
F
P
L
T
V
N
Y
Q
E
R
T
Y
A
A
G
R
I
P
G
S
F
F
R
R
E
G
R
P
S
E
G
E
T
L
I
A
R
L
I
D
R
P
I
R
P
L
F
P
E
G
F
V
N
E
V
Q
V
I
A
T
V
V
S
V
N
P
Q
V
N
P
D
I
V
A
M
I
G
A
S
A
A
L
S
L
S
G
I
P
F
N
G
P
I
G
A
A
R
V
G
-
Y
I
-
N
D
Q
Y
V
L
N
P
T
Q
D
E
L
K
E
S
K
L
D
L
V
V
A
G
-
T
E
-
A
A
-
V
L
M
V
E
S
E
A
Q
L
L
S
E
D
Q
M
L
G
A
V
V
F
G
H
E
Q
Q
----
Q
V
V
I
Q
N
I
N
E
L
V
K
E
A
G
K
-
P
R
W
D
W
Q
P
E
P
--
V
N
E
A
---
L
N
A
--
R
V
A
A
L
-
A
E
AR
L
S
D
A
Y
R
--
I
T
D
-----
K
Q
E
-----
R
Y
A
Q
V
D
V
I
K
S
E
T
I
------
A
T
L
LA---
E
D
--
E
--
T
L
D
E
N
E
L
G
E
I
L
H
A
I
E
K
N
V
V
R
S
R
V
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A
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R
I
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R
E
K
D
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I
R
G
L
D
V
R
T
G
V
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
L
V
T
A
T
L
G
T
A
R
----
D
----
A
----
Q
V
L
D
E
L
M
G
E
R
T
D
T
F
L
F
H
Y
N
F
P
P
Y
S
V
G
E
T
G
M
V
G
S
P
K
R
R
E
I
G
H
G
R
L
A
K
R
G
V
L
A
V
M
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D
M
D
K
F
P
Y
T
V
R
V
V
S
E
I
T
E
S
N
G
S
S
S
M
A
S
V
C
G
A
S
L
A
L
M
D
A
G
V
P
I
K
A
A
V
A
G
I
A
M
G
L
V
K
E
G
-------
D
-------
N
Y
V
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
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R
D
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I
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A
L
Q
M
D
I
K
I
E
G
I
T
K
E
I
M
Q
V
A
L
N
Q
A
K
G
A
R
L
H
I
L
G
V
M
E
Q
A
I
N
A
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
81.38
47%
-92
- C4 -
3H1C
3
PNP_ECOLI
C:
[1-544]
M
L
N
P
I
V
R
K
F
Q
Y
G
Q
H
T
V
T
L
E
T
G
M
M
A
R
Q
A
T
A
A
V
M
V
S
M
D
D
T
A
V
F
V
T
V
V
G
Q
K
K
A
-
K
P
G
-
Q
D
F
F
P
L
T
V
N
Y
Q
E
R
T
Y
A
A
G
R
I
P
G
S
F
F
R
R
E
G
R
P
S
E
G
E
T
L
I
A
R
L
I
D
R
P
I
R
P
L
F
P
E
G
F
V
N
E
V
Q
V
I
A
T
V
V
S
V
N
P
Q
V
N
P
D
I
V
A
M
I
G
A
S
A
A
L
S
L
S
G
I
P
F
N
G
P
I
G
A
A
R
V
G
-
Y
I
-
N
D
Q
Y
V
L
N
P
T
Q
D
E
L
K
E
S
K
L
D
L
V
V
A
G
-
T
E
-
A
A
-
V
L
M
V
E
S
E
A
Q
L
L
S
E
D
Q
M
L
G
A
V
V
F
G
H
E
Q
Q
----
Q
V
V
I
Q
N
I
N
E
L
V
K
E
A
G
K
-
P
R
W
D
W
Q
P
E
P
--
V
N
E
A
---
L
N
A
--
R
V
A
A
L
-
A
E
AR
L
S
D
A
Y
R
--
I
T
D
-----
K
Q
E
-----
R
Y
A
Q
V
D
V
I
K
S
E
T
I
------
A
T
L
LA---
E
D
--
E
--
T
L
D
E
N
E
L
G
E
I
L
H
A
I
E
K
N
V
V
R
S
R
V
L
A
G
E
P
R
I
D
G
R
E
K
D
M
I
R
G
L
D
V
R
T
G
V
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
L
V
T
A
T
L
G
T
A
R
----
D
----
A
----
Q
V
L
D
E
L
M
G
E
R
T
D
T
F
L
F
H
Y
N
F
P
P
Y
S
V
G
E
T
G
M
V
G
S
P
K
R
R
E
I
G
H
G
R
L
A
K
R
G
V
L
A
V
M
P
D
M
D
K
F
P
Y
T
V
R
V
V
S
E
I
T
E
S
N
G
S
S
S
M
A
S
V
C
G
A
S
L
A
L
M
D
A
G
V
P
I
K
A
A
V
A
G
I
A
M
G
L
V
K
E
G
-------
D
-------
N
Y
V
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
S
R
D
G
I
S
A
L
Q
M
D
I
K
I
E
G
I
T
K
E
I
M
Q
V
A
L
N
Q
A
K
G
A
R
L
H
I
L
G
V
M
E
Q
A
I
N
A
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
81.31
47%
-89
- C4 -
3H1C
2
PNP_ECOLI
G:
[2-544]
-
L
N
P
I
V
R
K
F
Q
Y
G
Q
H
T
V
T
L
E
T
G
M
M
A
R
Q
A
T
A
A
V
M
V
S
M
D
D
T
A
V
F
V
T
V
V
G
Q
K
K
A
-
K
P
G
-
Q
D
F
F
P
L
T
V
N
Y
Q
E
R
T
Y
A
A
G
R
I
P
G
S
F
F
R
R
E
G
R
P
S
E
G
E
T
L
I
A
R
L
I
D
R
P
I
R
P
L
F
P
E
G
F
V
N
E
V
Q
V
I
A
T
V
V
S
V
N
P
Q
V
N
P
D
I
V
A
M
I
G
A
S
A
A
L
S
L
S
G
I
P
F
N
G
P
I
G
A
A
R
V
G
-
Y
I
-
N
D
Q
Y
V
L
N
P
T
Q
D
E
L
K
E
S
K
L
D
L
V
V
A
G
-
T
E
-
A
A
-
V
L
M
V
E
S
E
A
Q
L
L
S
E
D
Q
M
L
G
A
V
V
F
G
H
E
Q
Q
----
Q
V
V
I
Q
N
I
N
E
L
V
K
E
A
G
K
-
P
R
W
D
W
Q
P
E
P
--
V
N
E
A
---
L
N
A
--
R
V
A
A
L
-
A
E
AR
L
S
D
A
Y
R
--
I
T
D
-----
K
Q
E
-----
R
Y
A
Q
V
D
V
I
K
S
E
T
I
------
A
T
L
LA---
E
D
--
E
--
T
L
D
E
N
E
L
G
E
I
L
H
A
I
E
K
N
V
V
R
S
R
V
L
A
G
E
P
R
I
D
G
R
E
K
D
M
I
R
G
L
D
V
R
T
G
V
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
L
V
T
A
T
L
G
T
A
R
----
D
----
A
----
Q
V
L
D
E
L
M
G
E
R
T
D
T
F
L
F
H
Y
N
F
P
P
Y
S
V
G
E
T
G
M
V
G
S
P
K
R
R
E
I
G
H
G
R
L
A
K
R
G
V
L
A
V
M
P
D
M
D
K
F
P
Y
T
V
R
V
V
S
E
I
T
E
S
N
G
S
S
S
M
A
S
V
C
G
A
S
L
A
L
M
D
A
G
V
P
I
K
A
A
V
A
G
I
A
M
G
L
V
K
E
G
-------
D
-------
N
Y
V
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
S
R
D
G
I
S
A
L
Q
M
D
I
K
I
E
G
I
T
K
E
I
M
Q
V
A
L
N
Q
A
K
G
A
R
L
H
I
L
G
V
M
E
Q
A
I
N
A
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
81.29
47%
-91
- C4 -
3H1C
2
PNP_ECOLI
T:
[2-544]
-
L
N
P
I
V
R
K
F
Q
Y
G
Q
H
T
V
T
L
E
T
G
M
M
A
R
Q
A
T
A
A
V
M
V
S
M
D
D
T
A
V
F
V
T
V
V
G
Q
K
K
A
-
K
P
G
-
Q
D
F
F
P
L
T
V
N
Y
Q
E
R
T
Y
A
A
G
R
I
P
G
S
F
F
R
R
E
G
R
P
S
E
G
E
T
L
I
A
R
L
I
D
R
P
I
R
P
L
F
P
E
G
F
V
N
E
V
Q
V
I
A
T
V
V
S
V
N
P
Q
V
N
P
D
I
V
A
M
I
G
A
S
A
A
L
S
L
S
G
I
P
F
N
G
P
I
G
A
A
R
V
G
-
Y
I
-
N
D
Q
Y
V
L
N
P
T
Q
D
E
L
K
E
S
K
L
D
L
V
V
A
G
-
T
E
-
A
A
-
V
L
M
V
E
S
E
A
Q
L
L
S
E
D
Q
M
L
G
A
V
V
F
G
H
E
Q
Q
----
Q
V
V
I
Q
N
I
N
E
L
V
K
E
A
G
K
-
P
R
W
D
W
Q
P
E
P
--
V
N
E
A
---
L
N
A
--
R
V
A
A
L
-
A
E
AR
L
S
D
A
Y
R
--
I
T
D
-----
K
Q
E
-----
R
Y
A
Q
V
D
V
I
K
S
E
T
I
------
A
T
L
LA---
E
D
--
E
--
T
L
D
E
N
E
L
G
E
I
L
H
A
I
E
K
N
V
V
R
S
R
V
L
A
G
E
P
R
I
D
G
R
E
K
D
M
I
R
G
L
D
V
R
T
G
V
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
L
V
T
A
T
L
G
T
A
R
----
D
----
A
----
Q
V
L
D
E
L
M
G
E
R
T
D
T
F
L
F
H
Y
N
F
P
P
Y
S
V
G
E
T
G
M
V
G
S
P
K
R
R
E
I
G
H
G
R
L
A
K
R
G
V
L
A
V
M
P
D
M
D
K
F
P
Y
T
V
R
V
V
S
E
I
T
E
S
N
G
S
S
S
M
A
S
V
C
G
A
S
L
A
L
M
D
A
G
V
P
I
K
A
A
V
A
G
I
A
M
G
L
V
K
E
G
-------
D
-------
N
Y
V
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
S
R
D
G
I
S
A
L
Q
M
D
I
K
I
E
G
I
T
K
E
I
M
Q
V
A
L
N
Q
A
K
G
A
R
L
H
I
L
G
V
M
E
Q
A
I
N
A
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
80.82
47%
-90
- C4 -
3H1C
2
PNP_ECOLI
M:
[1-544]
M
L
N
P
I
V
R
K
F
Q
Y
G
Q
H
T
V
T
L
E
T
G
M
M
A
R
Q
A
T
A
A
V
M
V
S
M
D
D
T
A
V
F
V
T
V
V
G
Q
K
K
A
-
K
P
G
-
Q
D
F
F
P
L
T
V
N
Y
Q
E
R
T
Y
A
A
G
R
I
P
G
S
F
F
R
R
E
G
R
P
S
E
G
E
T
L
I
A
R
L
I
D
R
P
I
R
P
L
F
P
E
G
F
V
N
E
V
Q
V
I
A
T
V
V
S
V
N
P
Q
V
N
P
D
I
V
A
M
I
G
A
S
A
A
L
S
L
S
G
I
P
F
N
G
P
I
G
A
A
R
V
G
-
Y
I
-
N
D
Q
Y
V
L
N
P
T
Q
D
E
L
K
E
S
K
L
D
L
V
V
A
G
-
T
E
-
A
A
-
V
L
M
V
E
S
E
A
Q
L
L
S
E
D
Q
M
L
G
A
V
V
F
G
H
E
Q
Q
----
Q
V
V
I
Q
N
I
N
E
L
V
K
E
A
G
K
-
P
R
W
D
W
Q
P
E
P
--
V
N
E
A
---
L
N
A
--
R
V
A
A
L
-
A
E
AR
L
S
D
A
Y
R
--
I
T
D
-----
K
Q
E
-----
R
Y
A
Q
V
D
V
I
K
S
E
T
I
------
A
T
L
LA---
E
D
--
E
--
T
L
D
E
N
E
L
G
E
I
L
H
A
I
E
K
N
V
V
R
S
R
V
L
A
G
E
P
R
I
D
G
R
E
K
D
M
I
R
G
L
D
V
R
T
G
V
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
L
V
T
A
T
L
G
T
A
R
----
D
----
A
----
Q
V
L
D
E
L
M
G
E
R
T
D
T
F
L
F
H
Y
N
F
P
P
Y
S
V
G
E
T
G
M
V
G
S
P
K
R
R
E
I
G
H
G
R
L
A
K
R
G
V
L
A
V
M
P
D
M
D
K
F
P
Y
T
V
R
V
V
S
E
I
T
E
S
N
G
S
S
S
M
A
S
V
C
G
A
S
L
A
L
M
D
A
G
V
P
I
K
A
A
V
A
G
I
A
M
G
L
V
K
E
G
-------
D
-------
N
Y
V
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
S
R
D
G
I
S
A
L
Q
M
D
I
K
I
E
G
I
T
K
E
I
M
Q
V
A
L
N
Q
A
K
G
A
R
L
H
I
L
G
V
M
E
Q
A
I
N
A
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------