@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0021: (2015-11-27 )
MANEHLNLFSLENSDYIYADYNATFPVSDSVKESILEVLSKQVLNPSSLHRKGQEARRILQDARDNIRSAIGVPSNKEIVFTSGATEANSLVMKGIAGFQHVISAVEHPSILNSACNPHIIPVNQGGIVDLLALERILSELKGNRVIVSVMMANNETGVVQPVKEIAEIAHKFETIYHTDAAQSVGKIKVNMEDLGMDLLTLSAHKFGGIAGSGVLIFNKDLVIEPIIVGGGQEKGLRGGTENIVAIAGLSAALQSISNLLSKMDEIKELRDQLEYELLNLASGIKIFGKNSKRLPNTSLIYMPGVKSDVQLMNFDLNNIAVSNGSACSSGKVEPSHVLLAMGATREQAECSIRVSIGPQTKPRDIRKIVDCWYNIYEKNILDMRK
Atome Classification :
(27 SA)
.........10........20........30........40.--.......-50........60........70..-.-....--.80........90..------------....-----------.-.-----100--------------..-......110--.--------..-------.--------.--------.---------..-------120.....-....130--------.......140.......150.......160......---------.170.----------...----------.-..180.......190.......200.......--210.....--..220-----.--..-------....---..230.......240......--.250...---------...-.260.-..-....270.......280.-.....-----.-290--..-----.-----......300.....--..310.......320.......330.-.-.....340.......350.......360.......370.......380....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MANE
H
L
N
L
F
S
LENS
D
Y
I
Y
A
DYNATFPV
S
D
S
V
K
E
S
I
L
E
V
L
S
K
Q--VL
N
P
S
S
L
-
H
R
K
G
Q
E
A
R
R
I
L
Q
D
A
R
D
N
I
R
S
A
IGV-P-SNK
E
--
I
V
F
TSGAT
E
A
N
S
L
V
M
------------
K
G
I
A
-----------
G
-
F
-----
Q
-
H
--------------
V
I
-
S
AVEH
P
S
I
---
L
--------
N
S-------A--------C--------N---------P
H
-------
I
--
I
PVNQ-GG
I
V
D
L
L
--------
A
L
E
R
I
L
S
E
LKG
N
R
V
I
V
S
V
M
MANNETG
V
V
Q
P
V
K
E
I
A
E
---------
I
A
H
K
F
----------
E
T
I
----------Y-H
T
D
A
AQSV
G
K
I
K
V
N
M
E
DLGMD
L
L
T
LSAHKFGG--IAG
S
G
V
L
I
--FNK-------D--
L
V
-------
I
E
P
I
---
I
VGGGQEKGLRGGTE
N
I
V
A
I
A
--
G
L
S
A
A
L
Q
---------
S
I
S
-
N
L
L
S
K
-
M
D
-
E
I
K
E
L
R
D
Q
L
E
Y
E
L
L
N
L
AS-G
I
K
I
F-----G-K----NS-----K-----RLPNT
S
L
I
Y
MPGVK--SD
V
Q
L
M
N
F
DL
N
N
I
A
VSNGSACSSGKV-E-P
S
H
V
L
L
AMGATREQA
E
C
S
I
R
V
SIGPQTK
P
R
D
I
R
K
I
V
D
C
W
Y
N
I
Y
E
K
N
I
LDMRK
1
PsiBlast_PDB
93.17
42%
-100
- C2 -
4IXO
2
?
A:
[10-376]
----------------
I
Y
L
D
H
N
A
T
T
F
I
D
P
R
V
K
E
F
I
I
S
L
M
D
K
E
---
L
N
P
S
S
A
-
H
S
S
G
R
F
A
K
N
L
I
E
T
V
R
A
Q
I
A
T
A
L
G
I
-
T
L
S
S
R
E
Y
D
I
T
F
T
S
S
G
T
E
G
N
N
L
I
M
------------
K
N
F
Y
-----------
D
-
G
-----
D
-
I
--------------
F
I
-
S
A
I
E
H
L
S
I
YNH
I
--------
N
Y
-------
A
--------
P
--------
N
---------
I
K
-------
V
--
I
S
V
N
T
-
Q
G
L
V
D
L
E
--------
H
L
E
E
L
L
A
Q
S
N
T
S
K
K
L
V
S
I
I
M
A
N
N
E
S
G
V
L
Q
D
I
A
E
I
G
K
---------
I
T
K
K
Y
----------
E
A
K
----------
F
-
H
S
D
L
V
Q
G
F
G
R
I
P
I
N
I
K
A
L
G
L
D
F
A
T
I
S
G
H
K
I
G
G
--
G
Q
G
G
A
A
L
I
--
S
S
S
-------
N
--
F
Q
-------
I
T
P
M
---
I
I
G
G
G
Q
E
K
S
V
R
S
G
T
E
N
V
L
A
I
A
G
F
G
L
A
S
A
L
R
---------
T
-
D
-
N
I
S
E
N
-
Y
I
-
K
I
K
K
L
Q
E
N
L
E
K
K
L
K
K
Y
P
N
--
V
N
I
V
-----
S
-
N
----
N
V
-----
A
-----
R
L
P
N
T
T
L
I
T
I
P
N
T
D
--
A
Q
A
K
L
I
G
F
D
L
H
N
I
C
V
S
S
G
------------
S
H
V
L
T
N
M
G
V
G
E
E
E
A
K
S
S
I
R
I
S
L
S
H
T
N
T
V
R
D
I
E
A
F
I
E
A
F
E
E
I
Y
D
V
-------
59
Fugue
88.93
32%
-93
- C2 -
4ISY
3
ISCSL_MYCTU
A:
[12-398]
---------------
S
A
Y
L
D
H
A
A
T
T
P
M
H
P
A
A
I
E
A
M
A
A
V
Q
-
R
T
--
I
G
N
A
S
S
L
-
H
T
S
G
R
S
A
R
R
R
I
E
E
A
R
E
L
I
A
D
K
L
G
A
-
R
--
P
S
E
--
V
I
F
T
A
G
G
T
E
S
D
N
L
A
V
------------
K
G
I
Y
-----------
W
-
A
-----
R
-
R
D
A
EPHRR
R
I
-----
V
T
-
T
E
V
E
H
H
A
V
---
L
--------
D
S
-------
V
N
W
L
V
E
HEG
A
--------
H
---------
V
T
-------
W
--
L
P
T
A
A
-
D
G
S
V
S
A
T
--------
A
L
R
E
A
L
Q
S
-
H
D
D
V
A
L
V
S
V
M
W
A
N
N
E
V
G
T
I
L
P
I
A
E
M
S
V
---------
V
A
M
E
F
----------
G
V
P
----------
M
-
H
S
D
A
I
Q
A
V
G
Q
L
P
L
D
F
G
A
S
G
L
S
A
M
S
V
A
G
H
K
F
G
G
--
P
P
G
V
G
A
L
L
--
L
R
R
-------
D
--
V
T
-------
C
V
P
L
---
M
H
G
G
G
Q
E
R
D
I
R
S
G
T
P
D
V
A
S
A
V
--
G
M
A
T
A
A
Q
I
--------
A
V
D
-
G
L
E
E
N
-
S
A
-
R
L
R
L
L
R
D
R
L
V
E
G
V
L
A
E
I
D
-
D
V
C
L
N
-----
G
A
D
----
D
P
-----
M
-----
R
L
A
G
N
A
H
F
T
F
R
G
C
E
--
G
D
A
L
L
M
L
L
D
A
N
G
I
E
C
S
T
G
S
----------
P
S
H
V
L
I
A
M
G
V
D
A
A
S
A
R
G
S
L
R
L
S
L
G
H
T
S
V
E
A
D
V
D
A
A
L
E
V
L
P
G
A
V
A
R
A
R
R
A
A
L
A
35
HHSearch
85.64
35%
-97
- C2 -
1EG5
3
?
A:
[2-376]
---------------
R
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
E
K
--
Y
G
N
P
N
S
A
-
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
---
S
P
S
E
--
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
------------
K
T
V
A
E
T
F
EK------
R
-
K
-----
R
T
I
--------------
I
T
-
T
P
I
E
H
K
A
V
---
L
--------
E
T
-------
M
--------
K
Y
L
S
M
K
G
F
-
K
---------
V
K
-------
Y
--
V
P
V
D
S
-
R
G
V
V
K
L
E
--------
E
L
E
K
L
V
D
---
E
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
---------
I
V
K
K
K
NK--------
E
T
L
----------
V
-
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
--
P
K
G
V
G
I
T
Y
--
I
R
K
-------
G
--
V
P
-------
I
R
P
L
---
I
H
G
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
--
G
A
A
R
A
M
E
---------
I
A
V
-
E
E
L
S
E
A
A
K
-
H
M
E
K
L
R
S
K
L
V
S
G
L
M
N
L
---
G
A
H
I
I
-----
T
-
P
----
L
E
-----
I
-----
S
L
P
N
T
L
S
V
S
F
P
N
I
R
--
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
--------------
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
------
58
Fugue
84.64
34%
-91
* C2 *
1ECX
2
?
A:
[1-376]
--------------
M
R
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
E
K
--
Y
G
N
P
N
S
A
-
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
--
V
-
S
P
S
E
--
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
------------
K
T
V
A
E
T
F
EKR-----
K
-
R
-----
T
-
I
--------------
I
T
-
T
P
I
E
H
K
A
V
---
L
--------
E
T
-------
M
--------
K
--------
Y
---------
L
S
M
K
G
F
K
V
K
Y
--
V
P
V
D
S
-
R
G
V
V
K
L
E
--------
E
L
E
K
L
V
D
E
---
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
---------
I
V
K
K
K
NK--------
E
T
L
----------
V
-
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
--
P
K
G
V
G
I
T
Y
--
I
R
K
-------
G
--
V
P
-------
I
R
P
L
---
I
H
G
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
--
G
A
A
R
A
M
E
---------
I
A
V
E
E
L
S
E
A
-
A
K
-
H
M
E
K
L
R
S
K
L
V
S
G
L
M
N
L
---
G
A
H
I
I
-----
T
-
P
----
L
E
-----
I
-----
S
L
P
N
T
L
S
V
S
F
P
N
I
R
--
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
--------------
T
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
------
6
PsiBlast_PDB
83.91
34%
-84
- C2 -
3LVJ
2
ISCS_ECO57
A:
[24-390]
----------------
I
Y
L
D
Y
S
A
T
T
P
V
D
P
R
V
A
E
K
M
M
Q
F
M
T
M
D
GT
F
G
N
P
A
S
R
S
H
R
F
G
W
Q
A
E
E
A
V
D
I
A
R
N
Q
I
A
D
L
V
G
A
-
D
-
P
-
R
E
--
I
V
F
T
S
G
A
T
E
S
D
N
L
A
I
------------
K
G
A
A
-----------
N
-
F
Y
QKKG
K
-
H
--------------
I
I
T
S
K
T
E
H
K
A
V
---
L
--------
D
T
----------------
C
--------
R
Q
L
E
R
E
G
F
E
V
T
Y
-------
L
--
A
P
-
Q
R
-
N
G
I
I
D
L
K
--------
E
L
E
---
A
A
M
R
D
D
T
I
L
V
S
I
M
H
V
N
N
E
I
G
V
V
Q
D
I
A
A
I
G
E
---------
M
C
R
A
R
----------
G
I
I
----------
Y
-
H
V
D
A
T
Q
S
V
G
K
L
P
I
D
L
S
Q
L
K
V
D
L
M
S
F
S
G
H
K
I
Y
G
--
P
K
G
I
G
A
L
Y
--
V
R
R
-------
K
P
R
V
R
-------
I
E
A
Q
---
M
H
G
G
G
H
E
R
G
M
R
S
G
T
L
P
V
H
Q
I
V
--
G
M
G
E
A
Y
R
I
--------
A
K
E
-
E
M
A
T
E
-
M
E
-
R
L
R
G
L
R
N
R
L
W
N
G
I
K
D
I
E
E
--
V
Y
L
N
-----
G
-
D
----
L
E
-----
H
-----
G
A
P
N
I
L
N
V
S
F
N
Y
V
E
--
G
E
S
L
I
M
A
--
L
K
D
L
A
V
S
S
G
------
S
L
-
E
-
P
S
Y
V
L
R
A
L
G
L
N
D
E
L
A
H
S
S
I
R
F
S
L
G
R
F
T
T
E
E
E
I
D
Y
T
I
E
L
V
R
K
S
I
G
R
L
R
D
L
S
P
L
24
PsiBlast_CBE
82.70
34%
-86
- C2 -
3LVJ
2
ISCS_ECO57
B:
[24-390]
----------------
I
Y
L
D
Y
S
A
T
T
P
V
D
P
R
V
A
E
K
M
M
Q
F
M
T
M
D
GT
F
G
N
P
A
S
R
S
H
R
F
G
W
Q
A
E
E
A
V
D
I
A
R
N
Q
I
A
D
L
V
G
A
-
D
-
P
-
R
E
--
I
V
F
T
S
G
A
T
E
S
D
N
L
A
I
------------
K
G
A
A
-----------
N
-
F
YQKKG
K
-
H
--------------
I
I
T
S
K
T
E
H
K
A
V
---
L
--------
D
T
----------------
C
--------
R
QLEREGFEV
T
Y
-------
L
--
A
P
-
Q
R
-
N
G
I
I
D
L
K
--------
E
L
E
---
A
A
M
R
D
D
T
I
L
V
S
I
M
H
V
N
N
E
I
G
V
V
Q
D
I
A
A
I
G
E
---------
M
C
R
A
R
----------
G
I
I
----------
Y
-
H
V
D
A
T
Q
S
V
G
K
L
P
I
D
L
S
Q
L
K
V
D
L
M
S
F
S
G
H
K
I
Y
G
--
P
K
G
I
G
A
L
Y
--
V
R
R
-------
K
PR
V
R
-------
I
E
A
Q
---
M
H
G
G
G
H
E
R
G
M
R
S
G
T
L
P
V
H
Q
I
V
--
G
M
G
E
A
Y
R
I--------
A
K
E
-
E
M
A
T
E
-
M
E
-
R
L
R
G
L
R
N
R
L
W
N
G
I
K
D
I
E
E
--
V
Y
L
N
-----
G
-
D
----
L
E
-----
H
-----
G
A
P
N
I
L
N
V
S
F
N
Y
V
E
--
G
E
S
L
I
M
A
--
L
K
D
L
A
V
S
S
G
S
A
C
----
L
-
E
-
P
S
Y
V
L
R
A
L
G
L
N
D
E
L
A
H
S
S
I
R
F
S
L
G
R
F
T
T
E
E
E
I
D
Y
T
I
E
L
V
R
K
S
I
G
R
L
R
D
L
S
P
L
7
PsiBlast_PDB
82.23
34%
-84
- C2 -
3LVK
1
ISCS_ECO57
A:
[24-390]
----------------
I
Y
L
D
Y
S
A
T
T
P
V
D
P
R
V
A
E
K
M
M
Q
F
M
T
M
D
GT
F
G
N
P
A
S
R
S
H
R
F
G
W
Q
A
E
E
A
V
D
I
A
R
N
Q
I
A
D
L
V
G
A
-
D
-
P
-
R
E
--
I
V
F
T
S
G
A
T
E
S
D
N
L
A
I
------------
K
G
A
A
-----------
N
-
F
Y
QKKG
K
-
H
--------------
I
I
T
S
K
T
E
H
K
A
V
---
L
--------
D
T
----------------
C
--------
R
Q
L
E
R
E
G
F
E
V
T
Y
-------
L
--
A
P
-
Q
R
-
N
G
I
I
D
L
K
--------
E
L
E
---
A
A
M
R
D
D
T
I
L
V
S
I
M
H
V
N
N
E
I
G
V
V
Q
D
I
A
A
I
G
E
---------
M
C
R
A
R
----------
G
I
I
----------
Y
-
H
V
D
A
T
Q
S
V
G
K
L
P
I
D
L
S
Q
L
K
V
D
L
M
S
F
S
G
H
K
I
Y
G
--
P
K
G
I
G
A
L
Y
--
V
R
R
-------
K
P
R
V
R
-------
I
E
A
Q
---
M
H
G
G
G
H
E
R
G
M
R
S
G
T
L
P
V
H
Q
I
V
--
G
M
G
E
A
Y
R
I
--------
A
K
E
-
E
M
A
T
E
-
M
E
-
R
L
R
G
L
R
N
R
L
W
N
G
I
K
D
I
E
E
--
V
Y
L
N
-----
G
-
D
----
L
E
-----
H
-----
G
A
P
N
I
L
N
V
S
F
N
Y
V
E
--
G
E
S
L
I
M
A
--
L
K
D
L
A
V
S
S
G
S
A
C
----
L
-
E
-
P
S
Y
V
L
R
A
L
G
L
N
D
E
L
A
H
S
S
I
R
F
S
L
G
R
F
T
T
E
E
E
I
D
Y
T
I
E
L
V
R
K
S
I
G
R
L
R
D
L
S
P
L
40
HHSearch
81.94
33%
-79
- C2 -
3A9Z
5
SCLY_RAT
A:
[18-430]
--------------
R
K
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
A
M
K
E
A
--
W
G
N
P
S
S
S
-
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
---
K
P
Q
D
--
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
------------
H
S
T
V
R
C
F
H
E
Q
Q
T
L
QT
R
-
P
-----
H
-
F
--------------
I
T
-
C
T
V
E
H
D
S
I
---
R
--------
L
P
-------
L
--------
E
H
L
V
E
D
QV
A
E
---------
V
T
-------
F
--
V
P
V
S
K
V
N
G
Q
V
E
V
E
--------
D
I
L
A
A
V
R
---
P
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
---------
R
I
K
A
L
N
Q
I
R
A
A
S
GL
P
R
V
L
----------
V
-
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
--
P
R
-
I
G
A
L
Y
--
V
R
G
-------
V
--
G
K
-------
L
T
P
L
Y
P
M
L
F
G
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
--
G
L
G
K
A
A
D
---------
L
V
S
-
E
N
C
E
T
Y
E
A
-
H
M
R
D
I
R
D
Y
L
E
E
R
L
E
A
-
E
F
-
G
K
R
I
H
-----
L
-
N
SRFP
G
V
-----
E
-----
R
L
P
N
T
C
N
F
S
I
Q
G
S
Q
LR
G
Y
M
V
L
A
--
Q
C
Q
T
L
L
A
S
V
G
A
S
C
H
S
D
H
E
D
R
-
P
S
P
V
L
L
S
C
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
E
G
P
V
--
5
PsiBlast_PDB
80.21
35%
-98
- C2 -
1ECX
2
?
A:
[3-353]
----------------
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
E
K
--
Y
G
N
P
N
S
A
-
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
---
S
P
S
E
--
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
------------
K
T
V
A
E
----------
T
-
F
-----
E
-
K
RKR
T
I
---------
I
T
-
T
P
I
E
H
K
A
V
---
L
--------
E
T
M
K
Y
L
S
M
K
G
--------
F
--------
K
---------
V
K
-------
Y
--
V
P
V
D
S
-
R
G
V
V
K
L
E
--------
E
L
E
K
L
V
D
E
---
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
---------
I
V
K
K
K
NK--------
E
T
L
----------
V
-
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
--
P
K
G
V
G
I
T
Y
--
I
R
K
-------
G
--
V
P
-------
I
R
P
L
---
I
H
G
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
--
G
A
A
R
A
M
E
I
--------
A
V
E
-
E
L
S
E
A
-
A
K
-
H
M
E
K
L
R
S
K
L
V
S
G
L
M
N
L
---
G
A
H
I
I
-----
T
-
P
----
L
E
-----
I
-----
S
L
P
N
T
L
S
V
S
F
P
N
I
R
--
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
--------------
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
------
23
PsiBlast_CBE
80.20
35%
-98
- C2 -
1ECX
2
?
B:
[3-353]
----------------
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
E
K
--
Y
G
N
P
N
S
A
-
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
---
S
P
S
E
--
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
------------
K
T
V
A
E----------
T
-
F
-----
E
-
K
RKRTI---------
I
T
-
T
P
I
E
H
K
A
V
---
L
--------
E
T
MKYLSMK
G
--------
F
--------
K
---------
V
K
-------
Y
--
V
P
V
D
S
-
R
G
V
V
K
L
E
--------
E
L
E
K
L
V
D
E
---
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
---------
I
V
K
K
K
NK--------
E
T
L
----------
V
-
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
--
P
K
G
V
G
I
T
Y
--
I
R
K
-------
G
--
V
P
-------
I
R
P
L
---
I
H
G
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
--
G
A
A
R
A
M
E
I--------
A
V
E
-
E
L
S
E
A
-
A
K
-
H
M
E
K
L
R
S
K
L
V
S
G
L
M
N
L
---
G
A
H
I
I
-----
T
-
P
----
L
E
-----
I
-----
S
L
P
N
T
L
S
V
S
F
P
N
I
R
--
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
-------------
R
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
------
8
PsiBlast_PDB
79.96
34%
-97
- C2 -
1EG5
3
?
A:
[3-353]
----------------
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
E
K
--
Y
G
N
P
N
S
A
-
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
---
S
P
S
E
--
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
------------
K
T
V
A
E
----------
T
-
F
-----
E
-
K
RKR
T
I
---------
I
T
-
T
P
I
E
H
K
A
V
---
L
--------
E
T
M
K
Y
L
S
M
K
G
--------
F
--------
K
---------
V
K
-------
Y
--
V
P
V
D
S
-
R
G
V
V
K
L
E
--------
E
L
E
K
L
V
D
E
---
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
---------
I
V
K
K
K
NK--------
E
T
L
----------
V
-
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
--
P
K
G
V
G
I
T
Y
--
I
R
K
-------
G
--
V
P
-------
I
R
P
L
---
I
H
G
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
--
G
A
A
R
A
M
E
I
--------
A
V
E
-
E
L
S
E
A
-
A
K
-
H
M
E
K
L
R
S
K
L
V
S
G
L
M
N
L
---
G
A
H
I
I
-----
T
-
P
----
L
E
-----
I
-----
S
L
P
N
T
L
S
V
S
F
P
N
I
R
--
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
--------------
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
------
4
PsiBlast_PDB
79.89
33%
-81
- C2 -
4HVK
12
ISCS2_ARCFU
A:
[3-372]
-----------------
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
E
S
--
F
G
N
P
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
--
G
-
G
G
G
T
--
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
------------
I
G
Y
A
M
R
N
ARK-----
G
-
K
-----
H
-
I
--------------
L
V
-
S
A
V
E
H
M
S
V
---
I
--------
N
P
-------
A
K
F
L
Q
K
Q
G-
F
--------
E
---------
V
E
-------
Y
--
I
P
V
G
K
-
Y
G
E
V
D
V
S
--------
F
I
D
Q
---
K
L
R
D
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
---------
V
L
A
G
-----------
K
A
A
----------
L
-
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
--
P
K
G
V
G
A
L
W
--
I
R
K
-------
E
--
A
K
-------
L
Q
P
V
---
I
L
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
--
G
F
G
K
A
A
E
---------------
I
T
A
-
M
E
-
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
N
-
V
L
K
I
E
E
S
Y
L
N
G
-
H
----
P
E
-----
K
-----
R
L
P
N
N
V
N
V
R
F
S
Y
I
E
--
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
---------
Q
-
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
S
P
-
2
PsiBlast_PDB
79.38
33%
-74
- C2 -
4EB5
6
ISCS2_ARCFU
A:
[3-372]
-----------------
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
E
S
--
F
G
N
P
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
--
G
-
G
G
G
T
--
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
------------
I
G
Y
A
M
R
N
ARK-----
G
-
K
-----
H
-
I
--------------
L
V
-
S
A
V
E
H
M
S
V
---
I
--------
N
P
-------
A
K
F
L
Q
K
Q
G-
F
--------
E
---------
V
E
-------
Y
--
I
P
V
G
K
-
Y
G
E
V
D
V
S
--------
F
I
D
Q
---
K
L
R
D
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
---------
V
L
A
G
-----------
K
A
A
----------
L
-
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
--
P
K
G
V
G
A
L
W
--
I
R
K
-------
E
--
A
K
-------
L
Q
P
V
---
I
L
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
--
G
F
G
K
A
A
E
---------------
I
T
A
-
M
E
-
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
N
-
V
L
K
I
E
E
S
Y
L
N
G
-
H
----
P
E
-----
K
-----
R
L
P
N
N
V
N
V
R
F
S
Y
I
E
--
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
S
S
K
T
L
-
Q
-
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
S
P
L
3
PsiBlast_PDB
78.87
33%
-75
- C2 -
4EB7
7
ISCS2_ARCFU
A:
[3-372]
-----------------
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
E
S
--
F
G
N
P
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
--
G
-
G
G
G
T
--
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
------------
I
G
Y
A
M
R
N
ARK-----
G
-
K
-----
H
-
I
--------------
L
V
-
S
A
V
E
H
M
S
V
---
I
--------
N
P
-------
A
K
F
L
Q
K
Q
G-
F
--------
E
---------
V
E
-------
Y
--
I
P
V
G
K
-
Y
G
E
V
D
V
S
--------
F
I
D
Q
---
K
L
R
D
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
---------
V
L
A
G
-----------
K
A
A
----------
L
-
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
--
P
K
G
V
G
A
L
W
--
I
R
K
-------
E
--
A
K
-------
L
Q
P
V
---
I
L
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
--
G
F
G
K
A
A
E
---------------
I
T
A
-
M
E
-
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
N
-
V
L
K
I
E
E
S
Y
L
N
G
-
H
----
P
E
-----
K
-----
R
L
P
N
N
V
N
V
R
F
S
Y
I
E
--
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
S
S
-
T
L
-
Q
-
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
S
P
L
9
PsiBlast_PDB
78.83
31%
-87
- C2 -
4ISY
3
ISCSL_MYCTU
A:
[14-378]
-----------------
Y
L
D
H
A
A
T
T
P
M
H
P
A
A
I
E
A
M
A
A
V
-
Q
R
T
--
I
G
N
A
S
S
L
-
H
T
S
G
R
S
A
R
R
R
I
E
E
A
R
E
L
I
A
D
K
L
G
A
R
P
-
S
--
E
--
V
I
F
T
A
G
G
T
E
S
D
N
L
A
V
------------
K
G
I
Y
-----------
W
-
A
-----
R
-
R
D
A
EPHRR
R
I
-----
V
T
-
T
E
V
E
H
H
A
V
---
L
--------
D
S
-------
V
--------
N
W
L
V
E
HE--
G
---------
A
H
-------
V
T
W
L
P
T
A
A
-
D
G
S
V
S
A
T
--------
A
L
R
E
A
L
-
Q
S
H
D
D
V
A
L
V
S
V
M
W
A
N
N
E
V
G
T
I
L
P
I
A
E
M
S
V
---------
V
A
M
E
F
----------
G
V
P
----------
M
-
H
S
D
A
I
Q
A
V
G
Q
L
P
L
D
F
G
A
S
G
L
S
A
M
S
V
A
G
H
K
F
G
G
--
P
P
G
V
G
A
L
L
--
L
R
R
-------
D
--
V
T
-------
C
V
P
L
---
M
H
G
G
G
Q
E
R
D
I
R
S
G
T
P
D
V
A
S
A
V
--
G
M
A
T
A
A
Q
I
A
V
D
G
L
E
E
N
S
A
R
-
L
R
L
L
R
-
D
R
-
L
V
E
G
V
L
A
E
I
D
D
V
C
L
N
G
A
--------------
D
----
D
P
-----
M
-----
R
L
A
G
N
A
H
F
T
F
R
G
C
E
--
G
D
A
L
L
M
L
L
D
A
N
G
I
E
C
S
T
G
S
----------
P
S
H
V
L
I
A
M
G
V
D
A
A
S
A
R
G
S
L
R
L
S
L
G
H
T
S
V
E
A
D
V
D
A
A
L
E
V
L
P
G
A
V
A
R
A
R
R
A
A
L
A
25
PsiBlast_CBE
78.53
31%
-85
- C2 -
4ISY
1
ISCSL_MYCTU
D:
[14-378]
-----------------
Y
L
D
H
A
A
T
T
P
M
H
P
A
A
I
E
A
M
A
A
V
-
Q
R
T
--
I
G
N
A
S
S
L
-
H
T
S
G
R
S
A
R
R
R
I
E
E
A
R
E
L
I
A
D
K
L
G
A
R
P
-
S
--
E
--
V
I
F
T
A
G
G
T
E
S
D
N
L
A
V
------------
K
G
I
Y
-----------
W
-
A
-----
R
-
R
DAEPHRRRI-----
V
T
-
T
E
V
E
H
H
A
V
---
L
--------
D
S
-------
V
--------
N
WLVEHE--
G
---------
A
H
-------
V
TW
L
P
T
A
A
-
D
G
S
V
S
A
T
--------
A
L
R
E
A
L
-
Q
S
H
D
D
V
A
L
V
S
V
M
W
A
N
N
E
V
G
T
I
L
P
I
A
E
M
S
V
---------
V
A
M
E
F
----------
G
V
P
----------
M
-
H
S
D
A
I
Q
A
V
G
Q
L
P
L
D
F
G
A
S
G
L
S
A
M
S
V
A
G
H
K
F
G
G
--
P
P
G
V
G
A
L
L
--
L
R
R
-------
D
--
V
T
-------
C
V
P
L
---
M
H
G
G
G
Q
E
R
D
I
R
S
G
T
P
D
V
A
S
A
V
--
G
M
A
T
A
A
Q
IAVDGLEEN
S
A
R
-
L
R
L
L
R
-
D
R
-
L
V
E
G
V
L
A
E
I
D
D
V
C
L
N
G
A
--------------
D
----
D
P
-----
M
-----
R
L
A
G
N
A
H
F
T
F
R
G
C
E
--
G
D
A
L
L
M
L
L
D
A
N
G
I
E
C
S
T
G
S
----------
P
S
H
V
L
I
A
M
G
V
D
A
A
S
A
R
G
S
L
R
L
S
L
G
H
T
S
V
E
A
D
V
D
A
A
L
E
V
L
P
G
A
V
A
R
A
R
R
A
A
L
A
26
PsiBlast_CBE
78.25
31%
-85
- C2 -
4ISY
3
ISCSL_MYCTU
C:
[14-378]
-----------------
Y
L
D
H
A
A
T
T
P
M
H
P
A
A
I
E
A
M
A
A
V
-
Q
R
T
--
I
G
N
A
S
S
L
-
H
T
S
G
R
S
A
R
R
R
I
E
E
A
R
E
L
I
A
D
K
L
G
A
R
P
-
S
--
E
--
V
I
F
T
A
G
G
T
E
S
D
N
L
A
V
------------
K
G
I
Y
-----------
W
-
A
-----
R
-
R
DAEPHRRRI-----
V
T
-
T
E
V
E
H
H
A
V
---
L
--------
D
S
-------
V
--------
N
WLVEHE--
G
---------
A
H
-------
V
TW
L
P
T
A
A
-
D
G
S
V
S
A
T
--------
A
L
R
E
A
L
-
Q
S
H
D
D
V
A
L
V
S
V
M
W
A
N
N
E
V
G
T
I
L
P
I
A
E
M
S
V
---------
V
A
M
E
F
----------
G
V
P
----------
M
-
H
S
D
A
I
Q
A
V
G
Q
L
P
L
D
F
G
A
S
G
L
S
A
M
S
V
A
G
H
K
F
G
G
--
P
P
G
V
G
A
L
L
--
L
R
R
-------
D
--
V
T
-------
C
V
P
L
---
M
H
G
G
G
Q
E
R
D
I
R
S
G
T
P
D
V
A
S
A
V
--
G
M
A
T
A
A
Q
IAVDGLEEN
S
A
R
-
L
R
L
L
R
-
D
R
-
L
V
E
G
V
L
A
E
I
D
D
V
C
L
N
G
A
--------------
D
----
D
P
-----
M
-----
R
L
A
G
N
A
H
F
T
F
R
G
C
E
--
G
D
A
L
L
M
L
L
D
A
N
G
I
E
C
S
T
G
S
A
---------
P
S
H
V
L
I
A
M
G
V
D
A
A
S
A
R
G
S
L
R
L
S
L
G
H
T
S
V
E
A
D
V
D
A
A
L
E
V
L
P
G
A
V
A
R
A
R
R
A
A
L
A
31
PsiBlast_CBE
78.24
31%
-70
- C2 -
3A9X
5
SCLY_RAT
B:
[20-418]
----------------
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
A
M
K
E
A
--
W
G
N
P
S
S
S
-
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
--
G
-
K
P
Q
D
--
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
------------
H
S
T
V
-----------
R
-
C
-----
F
-
H
E
Q
Q
T
L
QT
R
P
H
F
---
I
T
-
C
T
V
E
H
D
S
I
---
R
L
P
L
E
H
L
V
E
D
Q
-------
V
--------
A
--------
E
---------
V
T
-------
F
--
V
P
V
S
K
---
V
N
G
Q
V
--------
E
V
E
D
I
L
A
A
V
R
P
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
---------
R
I
K
A
L
----------
N
Q
I
R
A
A
S
G
L
P
R
V
L
V
-
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
PR
I
G
A
L
Y
V
R
G
--
V
G
K
-------
L
--
T
P
-------
L
Y
P
M
---
L
F
G
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
--
G
L
G
K
A
A
D
---------
L
V
S
E
N
C
E
T
Y
-
E
A
-
H
M
R
D
I
R
D
Y
L
E
-
E
R
L
E
A
E
F
-
G
K
R
I
H
-------
L
----
N
S
-----
R
FPG
V
E
R
L
P
N
T
C
N
F
S
I
Q
G
S
Q
--
L
R
G
Y
M
V
L
A
Q
C
Q
T
L
L
A
S
V
G
A
S
C
H
S
D
H
E
-
D
R
P
S
P
V
L
L
S
C
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
E
-----
22
PsiBlast_CBE
77.74
33%
-78
- C2 -
4EB5
5
ISCS2_ARCFU
B:
[3-372]
-----------------
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
E
S
--
F
G
N
P
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
--
G
-
G
G
G
T
--
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
------------
I
G
Y
A
MRNARK-----
G
-
K
-----
H
-
I
--------------
L
V
-
S
A
V
E
H
M
S
V
---
I
--------
N
P
-------
A
KFLQKQG-
F
--------
E
---------
V
E
-------
Y
--
I
P
V
G
K
-
Y
G
E
V
D
V
S
--------
F
I
D
Q
---
K
L
R
D
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
---------
V
L
A
G
-----------
K
A
A
----------
L
-
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
--
P
K
G
V
G
A
L
W
--
I
R
K
-------
E
--
A
K
-------
L
Q
P
V
---
I
L
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
--
G
F
G
K
A
A
E
---------------
I
T
A
-
M
E
-
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
N
-
V
L
K
I
E
ESYLN
G
-
H
----
P
E
-----
K
-----
R
L
P
N
N
V
N
V
R
F
S
Y
I
E
--
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
S
S
K
T
L
-
Q
-
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
S
P
-
10
PsiBlast_PDB
77.56
31%
-78
- C2 -
3GZC
2
SCLY_HUMAN
A:
[27-426]
----------------
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
M
T
K
A
M
W
E
A
--
W
G
N
P
S
S
P
-
Y
S
A
G
R
K
A
K
D
I
I
N
A
A
R
E
S
L
A
K
M
I
G
G
---
K
P
Q
D
--
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
V
V
K
H
F
H
A
N
Q
T--------------------------G
A
K
P
H
F
--------
I
T
-
S
S
V
E
H
D
S
I
---
R
L
P
L
E
H
L
V
E
E
Q
-------
V
--------
A
--------
A
---------
V
T
-------
F
--
V
P
V
S
K
---
V
S
G
Q
T
--------
E
V
D
D
I
L
A
A
V
R
P
T
T
R
L
V
T
I
M
L
A
N
N
E
T
G
I
V
M
P
V
P
E
I
S
Q
R
I
K
A
L
N
Q
E
R
V
A
A
G
L
----------
P
P
I
----------
L
V
H
T
D
A
A
Q
A
L
G
K
Q
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
--
P
R
I
G
A
L
Y
I
R
G
L
G
E
-------
F
--
T
P
-------
L
Y
P
M
---
L
F
G
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
--
G
L
G
K
A
A
E
---------
L
V
T
Q
N
C
E
A
Y
-
E
A
-
H
M
R
D
V
R
D
Y
L
E
-
E
R
L
E
A
E
F
-
G
Q
K
R
I
-----
H
-
L
----
N
S
QFPGT
Q
-----
R
L
P
N
T
C
N
F
S
I
R
G
P
R
--
L
Q
G
H
V
V
L
A
Q
C
R
V
L
M
A
S
V
G
A
A
C
H
S
D
H
G
D
Q
-
P
S
P
V
L
L
S
Y
G
V
P
F
D
V
A
R
N
A
L
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
V
V
Q
D
L
K
Q
A
V
A
Q
L
E
D
Q
---
21
PsiBlast_CBE
77.04
33%
-77
- C2 -
4EB7
4
ISCS2_ARCFU
B:
[3-372]
-----------------
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
E
S
--
F
G
N
P
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
--
G
-
G
G
G
T
--
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
------------
I
G
Y
A
MRNARK-----
G
-
K
-----
H
-
I
--------------
L
V
-
S
A
V
E
H
M
S
V
---
I
--------
N
P
-------
A
KFLQKQG-
F
--------
E
---------
V
E
-------
Y
--
I
P
V
G
K
-
Y
G
E
V
D
V
S
--------
F
I
D
Q
---
K
L
R
D
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
---------
V
L
A
G
-----------
K
A
A
----------
L
-
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
--
P
K
G
V
G
A
L
W
--
I
R
K
-------
E
--
A
K
-------
L
Q
P
V
---
I
L
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
--
G
F
G
K
A
A
E
---------------
I
T
A
-
M
E
-
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
N
-
V
L
K
I
E
ESYLN
G
-
H
----
P
E
-----
K
-----
R
L
P
N
N
V
N
V
R
F
S
Y
I
E
--
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
S
S
K
T
L
-
Q
-
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
S
P
-
13
PsiBlast_PDB
76.90
31%
-69
- C2 -
3A9Z
5
SCLY_RAT
A:
[20-418]
----------------
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
A
M
K
E
A
--
W
G
N
P
S
S
S
-
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
--
G
-
K
P
Q
D
--
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
------------
H
S
T
V
-----------
R
-
C
-----
F
-
H
E
Q
Q
T
L
QT
R
P
H
F
---
I
T
-
C
T
V
E
H
D
S
I
---
R
L
P
L
E
H
L
V
E
D
Q
-------
V
--------
A
--------
E
---------
V
T
-------
F
--
V
P
V
S
K
---
V
N
G
Q
V
--------
E
V
E
D
I
L
A
A
V
R
P
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
---------
R
I
K
A
L
----------
N
Q
I
R
A
A
S
GL
P
R
V
L
V
-
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
PR
I
G
A
L
Y
V
R
G
--
V
G
K
-------
L
--
T
P
-------
L
Y
P
M
---
L
F
G
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
--
G
L
G
K
A
A
D
---------
L
V
S
E
N
C
E
T
Y
-
E
A
-
H
M
R
D
I
R
D
Y
L
E
-
E
R
L
E
A
E
F
-
G
K
R
I
H
-------
L
----
N
S
-----
R
FPG
V
E
R
L
P
N
T
C
N
F
S
I
Q
G
S
Q
--
L
R
G
Y
M
V
L
A
Q
C
Q
T
L
L
A
S
V
G
A
S
C
H
S
D
H
E
-
D
R
P
S
P
V
L
L
S
C
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
E
G
P
V
--
30
PsiBlast_CBE
76.50
31%
-71
- C2 -
3A9Y
4
SCLY_RAT
B:
[20-418]
----------------
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
A
M
K
E
A
--
W
G
N
P
S
S
S
-
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
--
G
-
K
P
Q
D
--
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
------------
H
S
T
V
-----------
R
-
C
-----
F
-
H
E
Q
QT
R
P
H
F
------
I
T
-
C
T
V
E
H
D
S
I
---
R
L
P
L
E
H
L
V
E
D
Q
-------
V
--------
A
--------
E
---------
V
T
-------
F
--
V
P
V
S
K
---
V
N
G
Q
V
--------
E
V
E
D
I
L
A
A
V
R
P
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
---------
R
I
K
A
L
----------
N
Q
I
R
A
A
S
G
L
P
R
V
L
V
-
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
PR
I
G
A
L
Y
V
R
G
--
V
G
K
-------
L
--
T
P
-------
L
Y
P
M
---
L
F
G
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
--
G
L
G
K
A
A
D
---------
L
V
S
E
N
C
E
T
Y
-
E
A
-
H
M
R
D
I
R
D
Y
L
E
-
E
R
L
E
A
E
F
-
G
K
R
I
H
-------
L
----
N
S
-----
R
FPGVE
R
L
P
N
T
C
N
F
S
I
Q
G
S
Q
--
L
R
G
Y
M
V
L
A
Q
C
Q
T
L
L
A
S
V
G
A
S
C
H
S
D
H
E
-
D
R
P
S
P
V
L
L
S
C
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
E
G
P
V
--
32
PsiBlast_CBE
76.26
32%
-85
- C2 -
3VAX
2
?
B:
[22-378]
----------------
T
Y
L
D
A
A
A
T
T
R
V
D
Q
R
V
A
D
I
V
L
H
W
M
T
A
E
--
F
G
N
A
G
S
R
-
H
E
Y
G
I
R
A
K
R
G
V
E
R
A
R
E
Y
L
A
S
T
V
S
A
-
E
-
P
D
-
E
--
L
I
F
T
S
G
A
T
E
S
N
N
I
A
L
------------
L
G
L
A
PYGERT-----
G
-
R
-----
R
-
H
--------------
I
I
T
S
A
I
E
H
K
A
V
---
L
--------
E
P
-------
L
--------
E
-------------------
H
-------
L
----
A
G
R
-
G
F
E
V
D
F
L
TPGPSGRI
S
V
E
G
V
M
E
R
L
R
P
D
T
L
L
V
S
L
M
H
V
N
N
E
T
G
V
I
Q
P
V
A
E
L
A
Q
---------
Q
L
R
A
T
----------
P
T
Y
----------
L
-
H
V
D
A
A
Q
G
Y
G
K
V
P
G
D
L
-
T
T
P
I
D
M
I
S
I
S
G
H
K
I
G
A
--
P
K
G
V
G
A
L
V
--
T
R
R
REEMDDE
R
--
V
P
-------
L
E
P
I
---
M
F
G
G
G
Q
E
R
K
L
R
P
G
T
L
P
V
P
L
I
M
--
G
L
A
E
A
A
K
---------
I
F
E
-
A
E
H
A
Q
-
W
Q
V
A
A
Q
D
L
R
S
R
L
---
L
A
G
L
A
S
T
S
F
Q
V
N
-----
G
-
D
----
Q
D
-----
H
-----
V
V
P
H
I
L
N
L
S
F
E
D
V
D
--
A
E
A
F
L
V
T
L
K
-
D
L
V
A
V
A
T
G
S
A
S
T
S
A
S
F
-
T
-
P
S
H
V
L
R
A
M
G
L
P
E
E
A
A
S
K
S
L
R
F
S
W
T
P
G
--------------------------
14
PsiBlast_PDB
75.61
32%
-85
- C2 -
3VAX
1
?
A:
[22-378]
----------------
T
Y
L
D
A
A
A
T
T
R
V
D
Q
R
V
A
D
I
V
L
H
W
M
T
A
E
--
F
G
N
A
G
S
R
-
H
E
Y
G
I
R
A
K
R
G
V
E
R
A
R
E
Y
L
A
S
T
V
S
A
-
E
-
P
D
-
E
--
L
I
F
T
S
G
A
T
E
S
N
N
I
A
L
------------
L
G
L
A
P
Y
G
E
R
T
-----
G
-
R
-----
R
-
H
--------------
I
I
T
S
A
I
E
H
K
A
V
---
L
--------
E
P
-------
L
--------
E
-------------------
H
-------
L
----
A
G
R
-
G
F
E
V
D
F
L
T
PGPSGRI
S
V
E
G
V
M
E
R
L
R
P
D
T
L
L
V
S
L
M
H
V
N
N
E
T
G
V
I
Q
P
V
A
E
L
A
Q
---------
Q
L
R
A
T
----------
P
T
Y
----------
L
-
H
V
D
A
A
Q
G
Y
G
K
V
P
G
D
L
-
T
T
P
I
D
M
I
S
I
S
G
H
K
I
G
A
--
P
K
G
V
G
A
L
V
--
T
R
R
R
EEMDDE
R
--
V
P
-------
L
E
P
I
---
M
F
G
G
G
Q
E
R
K
L
R
P
G
T
L
P
V
P
L
I
M
--
G
L
A
E
A
A
K
---------
I
F
E
-
A
E
H
A
Q
-
W
Q
V
A
A
Q
D
L
R
S
R
L
---
L
A
G
L
A
S
T
S
F
Q
V
N
-----
G
-
D
----
Q
D
-----
H
-----
V
V
P
H
I
L
N
L
S
F
E
D
V
D
--
A
E
A
F
L
V
T
L
K
-
D
L
V
A
V
A
T
G
S
A
S
T
S
A
S
F
-
T
-
P
S
H
V
L
R
A
M
G
L
P
E
E
A
A
S
K
S
L
R
F
S
W
T
P
G
--------------------------
12
PsiBlast_PDB
74.95
31%
-70
- C2 -
3A9X
3
SCLY_RAT
A:
[20-418]
----------------
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
A
M
K
E
A
--
W
G
N
P
S
S
S
-
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
--
G
-
K
P
Q
D
--
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
------------
H
S
T
V
-----------
R
-
C
-----
F
-
H
E
Q
Q
T
L
Q
GEG
T
R
P
H
F
I
T
-
C
T
V
E
H
D
S
I
---
R
L
P
L
E
H
L
V
E
D
Q
-------
V
--------
A
--------
E
---------
V
T
-------
F
--
V
P
V
S
K
---
V
N
G
Q
V
--------
E
V
E
D
I
L
A
A
V
R
P
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
---------
R
I
K
A
L
----------
N
Q
I
R
A
A
S
G
L
P
R
V
L
V
-
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
PR
I
G
A
L
Y
V
R
G
--
V
G
K
-------
L
--
T
P
-------
L
Y
P
M
---
L
F
G
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
--
G
L
G
K
A
A
D
---------
L
V
S
E
N
C
E
T
Y
-
E
A
-
H
M
R
D
I
R
D
Y
L
E
-
E
R
L
E
A
E
F
-
G
K
R
I
H
-------
L
----
N
S
-----
R
FPGVE
R
L
P
N
T
C
N
F
S
I
Q
G
S
Q
--
L
R
G
Y
M
V
L
A
Q
C
Q
T
L
L
A
S
V
G
A
--------------------
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
E
G
P
V
--
37
HHSearch
71.38
31%
-76
- C2 -
3VAX
1
?
A:
[22-379]
----------------
T
Y
L
D
A
A
A
T
T
R
V
D
Q
R
V
A
D
I
V
L
H
W
M
T
A
E
--
F
G
N
A
G
S
R
-
H
E
Y
G
I
R
A
K
R
G
V
E
R
A
R
E
Y
L
A
S
T
V
S
A
---
E
P
D
E
--
L
I
F
T
S
G
A
T
E
S
N
N
I
A
L
------------
L
G
L
A
P
Y
G
E
R
T
-----
G
R
R
-----
H
-
I
--------------
I
T
-
S
A
I
E
H
K
A
V
---
L
--------
E
P
-------
L
--------
E
H
L
A
G
R
G
F
-
E
---------
V
D
-------
F
--
L
T
P
G
P
-
S
G
R
I
S
V
E
--------
G
V
M
E
R
L
R
---
P
D
T
L
L
V
S
L
M
H
V
N
N
E
T
G
V
I
Q
P
V
A
E
L
A
Q
---------
Q
L
R
A
T
----------
P
T
Y
----------
L
-
H
V
D
A
A
Q
G
Y
G
K
V
P
G
D
L
T
T
-
P
I
D
M
I
S
I
S
G
H
K
I
G
A
--
P
K
G
V
G
A
L
V
--
T
R
R
-------
R
--
E
E
MDDERVP
L
E
P
I
---
M
F
G
G
G
Q
E
R
K
L
R
P
G
T
L
P
V
P
L
I
M
--
G
L
A
E
A
A
K
---------
I
F
E
-
A
E
H
A
Q
W
Q
V
-
A
A
Q
D
L
R
S
R
L
L
A
G
L
A
S
T
---
S
F
Q
V
N
-----
G
-
D
----
Q
D
-----
H
-----
V
V
P
H
I
L
N
L
S
F
E
D
V
D
--
A
E
A
F
L
V
T
L
K
-
D
L
V
A
V
A
T
G
S
A
S
T
S
A
S
F
-
T
-
P
S
H
V
L
R
A
M
G
L
P
E
E
A
A
S
K
S
L
R
F
S
W
T
P
G
--------------------------