@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0039: (2015-11-27 )
MFLKVFKSIFLFLVSILFVCPILSLVSILFTESTNSEWVISTLFPEYILNTLILMIGVGSISFIFGVIPAWLTTFFSFPGSRIFEVALFFPISIPGYIISFVYVNSLEFSGPTQSLLREIFHWGKGDYWFPEIKSLGGGILVMGFSLYTYVYILVRSNLKNVSNSVTVASTLGFSSLQSLFSVVIPSIRPSIIAGISLVLMEVITDFGTPQFLAIDTFTTGIYRTWFLLHDKYSAAVLAVAELVFITALIAVEKILQKKEISYSAINTNSDYHNKRSISGAIPLVFAYAMCILPILVGFALPIIPLIYWSIEKGFFIYGARFYNIIANSIGLSFITAMISVSIAIMIGCTARKNKVINNIARLISLGYAIPNAVIAISIIIFLSKISSFITQYFTEISLVGTVGALIYSYLFRFFAISFKAIESGLKKTPNEIEWIAYTMGHGPISTCLNIHIPLIKKSILSGFLLVFMDTIKELTATLIIRPFNFETISTRIYELVSDERYREAAPFSLMIVITGLISTIILFKLDDENKK
Atome Classification :
(20 SA)
-------------------------------------------------------------------.........10........20..-----...-...30..-......-40...----......50........60........70........80----.........90.....---.----..100.......-110.......120.......130-.......140.......150.......160..-.-......170-...--....180.......190.......---200.......---210.--..--.-------------...220......---.230--.........240.......250.......260.......270.......280.......290.......300--------........310--.--.......-.320---.-.......330.......340.......----350---....---------..--...360-.......370.......380--------------.......390...-.-----...----400--------........410........420......----.430.......440.......450.......460.......470.......480...------------....490.----.....----.500.......--.510.......520.......530-------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------------------------
M
F
L
K
V
F
K
S
I
F
L
F
L
V
S
I
L
F
V
C
P
I
L
-----
S
L
V
-
S
I
L
FTES-TNS
E
W
V
-
I
-
S
T
L
----
F
P
E
Y
I
L
N
T
L
I
L
M
I
GV
G
S
I
S
F
I
F
G
V
I
P
A
W
L
T
T
F
FSFPG-----
S
R
I
F
E
V
A
L
F
F
PISI
P
G
---
Y
----
I
I
S
F
V
Y
V
NSLEF-SG
P
T
Q
S
L
L
R
E
I
F
H
WGKGDYW
F
P
E
-
I
K
SLG
G
G
I
L
V
M
G
F
S
L
Y
T
Y
V
Y
I
L
V
RS
N
L
K--NV-S-N
S
V
T
V
A
S
TL-
G
F
S
--
S
L
Q
S
L
F
S
V
V
IPSI
R
P
S
I
I
A
G
I
S
L
V
---
L
M
E
V
I
T
DFGT---P
Q
F
L
--
A
I
--D-------------TFT
T
G
I
Y
R
T
W
F
L
---
L
H----DK
Y
S
A
A
V
L
A
V
A
E
L
V
F
I
T
A
L
I
A
V
E
K
I
L
Q
K
KEI
S
Y
S
AINTNSDYHNKRSISG
A
I
P
L
V
F
A
Y
A
M
C
I
L
P
I
L
V
G
F
A
L
---------
P
I
I
P
L
I
Y
W
S----I--EK
G
F
F
I
Y-
G
A
R
----
F
-
Y
N
I
I
A
N
SI
G
L
S
F
I
T
A
M
I
S
V
S
I
A
I
M
I
GC----T-----AR
K
N
---------
K
V
--
I
N
N
I
A
R
-
L
I
S
L
G
Y
AI
P
N
A
V
I
A
I
S
I
I
I
F
--------------
L
S
K
I
S
S
F
I
T
Q
Y
F
T
-
E
-----
I
S
L
----
V
G
---------
T
V
G
A
L
I
Y
S
Y
L
-
F
R
F
F
A
I
S
F
K
A
I
E
S
G
L
KK----TPNE
I
E
W
I
A
Y
TMGH
G
P
I
S
T
C
L
N
I
H
I
P
L
I
K
K
S
I
L
S
G
F
L
L
V
F
M
D
T
I
K
E
L
T
A
T
L
I
I
RPF
N
------------
F
E
T
I
S
T
R
I
----
Y
E
L
VS----
D
E
-
R
YREAAPF--
S
L
M
I
V
I
T
G
L
I
S
T
I
I
L
F
K
LDDENKK-------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
75.93
22%
-116
- C2 -
3FH6
-
MALF_ECOLI
F:
[277-426]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-
L
A
I
F
V
W
T
V
V
F
S
L
I
T
V
F
L
T
V
A
V
G
M
V
L
A
C
LVQW
E
-----
A
L
R
G
---------
K
A
--
V
Y
R
V
---
L
L
I
L
P
Y
A
V
P
S
F
---
I
S
I
L
I
F
KGLFNQSFGEINMM
L
S
A
L
F
G
V
K
P
A
W
F
S
-
D
-----
P
T
T
----
A
R
---------
T
M
L
I
I
V
N
T
W
L
G
Y
P
Y
M
M
I
L
C
M
G
L
---
L
K
A
----
I
P
D
D
L
Y
E
A
S
A
M
D
G
A
G
P
F
Q
N
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
M
I
A
S
F
A
F
N
F
N
N
F
V
L
I
Q
L
L
T
N
G
G
------------
P
D
R
L
G
T
T
T
----
P
A
G
Y
T
----
D
L
-
L
V
N
Y
T
Y
R
I
--
A
F
E
G
G
G
G
Q
D
F
G
L
A
A
A
I
A
T
L
I
F
L
L
V
-------------------------------------------------------------------------------------------------------
34
Fugue
73.24
18%
-145
* C3 *
4P5F
1
?
A:
[8-374]
----------------------------------------------------------------LT
P
T
E
A
A
V
L
R
E
L
R
L
H
-------
R
P
Q
L
-----
P
L
D
-
T
L
L
F
T
D
P
-
N
K
D
---------------------------------------------------------------------
P
D
---
D
----
V
V
T
Y
T
I
A
K
Q
L
Q
A
-
D
G
----------------------------------
F
L
R
L
T
D
V
V
V
---------------------
T
L
-
G
D
A
--
D
M
R
S
Q
R
A
Q
L
A
K
G
V
F
D
R
L
--
A
L
P
D
V
---
R
V
A
R
G
Q
D
Y
P
M
---
T
S
T
Q
--
A
R
--
E
-------------
H
S
K
-------------
F
----
L
A
E
G
A
A
L
R
A
A
P
D
A
V
H
T
D
G
V
R
A
M
C
E
R
L
A
T
S
-------------------
P
H
K
L
G
M
V
V
I
A
G
M
T
D
A
S
A
L
L
A
E
A
G
---------
D
L
V
R
E
K
V
A
S
----
I
--
T
I
M
G
G
I
D
-
P
A
R
-----------
D
A
D
G
L
--------------
V
Q
P
----
D
-----
T
R
A
Y
---------
N
N
--
A
T
D
I
H
A
-
A
R
A
L
Y
R
R
A
Q
Q
L
G
I
P
L
R
I
L
T
K
--------------
E
A
A
Y
K
A
A
V
P
P
A
F
Y
-
E
-----
G
I
A
----
R
N
GH-------
P
V
G
E
Y
L
R
D
V
Q
-
K
N
A
L
K
G
L
W
E
G
I
Q
A
N
L
I
P
----
G
L
D
-
T
A
W
F
F
R
T
F
V
A
G
A
L
S
--
F
D
A
I
W
P
Q
V
T
K
--
L
N
L
Y
D
P
L
T
L
L
A
A
L
P
G
T
A
R
L
L
F
Q
P
T
P
------------
M
H
R
E
G
A
S
P
----
V
E
H
V
G
----
H
A
-
E
V
V
R
--
P
E
--
K
A
R
L
L
L
S
A
L
A
K
A
A
L
V
----------------------------------------------------------------------------------------------------------------
26
Fugue
71.56
20%
-117
- C2 -
2ONK
-
WTPB_ARCFU
C:
[24-275]
-----------------------------------------------------------------MR
L
L
F
S
A
L
L
A
L
L
S
S
I
I
L
L
F
V
L
L
P
V
A
-----
A
T
V
T
L
Q
L
F
N
F
D
-
E
F
L
K
A
A
-
S
-
D
P
A
----
V
W
K
V
V
L
T
T
Y
Y
A
A
L
I
S
T
L
I
A
V
I
F
G
T
P
L
A
Y
I
L
A
R
K
S
F
P
G
-----
K
S
V
V
E
G
I
V
D
L
P
V
V
I
P
H
---
T
----
V
A
G
I
A
L
L
V
V
F
G
S
-
S
G
L
I
G
S
F
S
P
-----------
L
K
F
-
V
D
A
L
P
G
I
V
V
A
M
L
F
V
S
V
P
I
Y
I
N
Q
A
K
E
G
F
A
--
S
V
D
V
-
R
L
E
H
V
A
R
T
L
-
G
S
S
--
P
L
R
V
F
F
T
V
S
L
P
L
S
V
R
H
I
V
A
G
A
I
M
S
---
W
A
R
G
I
S
E
F
G
A
---
V
V
V
I
--
A
Y
--
Y
-------------
P
M
I
A
P
T
L
I
Y
E
R
Y
---
L
S
----
E
G
L
S
A
A
-
M
P
V
A
A
I
L
I
L
L
S
L
A
V
F
V
A
L
R
I
I
V
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
69.55
21%
-110
- C2 -
2ONK
-
WTPB_ARCFU
C:
[33-275]
--------------------------------------------------------------------------
A
L
L
S
S
I
I
L
L
F
V
L
L
P
V
A
-----
A
T
V
-
T
L
Q
L
F
N
F
-
D
E
F
L
K
A
A
S
-
D
P
A
----
V
W
K
V
V
L
T
T
Y
Y
A
A
L
I
S
T
L
I
A
V
I
F
G
T
P
L
A
Y
I
L
A
R
K
S
F
P
G
-----
K
S
V
V
E
G
I
V
D
L
P
V
V
I
P
H
---
T
----
V
A
G
I
A
L
L
V
V
F
G
S
-
S
G
L
I
G
S
F
S
P
L
-----------
K
F
-
V
D
A
L
P
G
I
V
V
A
M
L
F
V
S
V
P
I
Y
I
N
Q
A
K
E
G
F
A
--
S
V
-
D
V
R
L
E
H
V
A
R
T
L
-
G
S
S
--
P
L
R
V
F
F
T
V
S
L
P
L
S
V
R
H
I
V
A
G
A
I
M
S
---
W
A
R
G
I
S
E
F
G
A
---
V
V
V
I
--
A
Y
YP
M
-------------
I
A
P
T
L
I
Y
E
R
Y
L
S
----
E
----
G
L
S
A
A
M
P
V
A
A
I
L
I
L
L
S
L
A
V
F
V
A
L
R
I
I
V
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Fugue
68.25
12%
-98
- C2 -
4A01
15
AVP_VIGRR
A:
[2-766]
GAAILP
D
L
G
T
E
I
L
I
P
V
C
A
V
I
G
I
A
F
A
L
F
Q
W
L
L
V
S
K
V
K
L
S
AVD
H
N
V
V
V
K
C
A
E
I
Q
N
A
I
S
E
G
A
T
S
F
L
F
T
E
Y
K
Y
V
G
I
F
M
V
A
F
A
I
L
I
F
L
F
L
G
S
V
E
G
FSTSP
Q
A
C
-
S
Y
D
K
T
K
T
-
C
K
P
A
L
A
-
T
-
A
I
F
----
S
T
V
S
F
L
L
G
G
V
T
S
L
V
S
G
F
L
G
M
K
I
A
T
Y
A
N
A
R
T
T
L
E
A
R
K
G
V
G
K
A
F
I
T
A
F
R
S
G
A
V
M
G
F
L
L
A
A
---
N
G
L
L
V
L
Y
I
A
I
N
L
F
K
I
Y
Y
-
G
D
D
W
G
G
L
F
E
A
I
T
G
Y
G
L
G
G
S
S
M
A
L
-
F
G
R
V
G
G
G
I
Y
T
K
A
A
D
V
G
A
D
L
V
G
K
V
E
R
N
I
P
ED
D
P
-
R
-
N
P
A
V
I
A
D
N
V
-
G
D
N
V
G
D
I
A
G
M
G
S
D
L
F
G
S
Y
A
E
S
S
C
A
A
L
V
V
A
S
I
S
S
F
G
L
N
H
E
L
T
A
M
L
Y
P
L
I
V
--
S
S
--
V
-------------
G
I
L
V
C
L
L
T
T
L
F
A
---
T
D
FFEI
K
A
V
K
E
I
E
P
A
L
K
K
Q
L
V
I
S
T
V
L
M
T
I
G
V
A
V
V
S
F
V
A
L
P
T
S
F
T
I
F
N
F
G
V
Q
K
D
V
K
S
W
Q
L
F
L
C
V
A
V
G
L
W
A
G
L
I
I
G
F
V
T
E
Y
Y
TSNAYS
P
V
Q
D
V
A
D
S
C
----
R
TG
A
A
T
N
V
I
F
-
G
L
A
----
L
G
Y
K
S
V
I
I
P
I
F
A
I
A
I
S
I
F
V
S
F
T
F
A
A
M
Y
G
I
----
A
-----
V
A
A
L
---------
G
M
--
L
S
T
I
A
T
-
G
L
A
I
D
A
Y
G
P
I
S
D
N
A
G
G
I
A
E
M
--------------
A
G
M
S
H
R
I
R
E
R
T
D
A
-
L
-----
D
A
A
----
G
N
---------
T
T
A
A
I
G
K
G
F
A
-
I
G
S
A
A
L
V
S
L
A
L
F
G
A
F
V
S
R
A
SI
T
T
V
D
V
L
T
P
K
V
F
I
G
L
I
V
G
A
M
L
P
Y
W
F
S
A
M
T
M
K
S
V
G
S
A
A
L
K
M
V
E
E
V
R
R
Q
F
N
T
I
P
G
L
M
E
G
T
------------
A
K
P
D
Y
A
T
C
----
V
K
I
S
T
----
D
A
-
S
I
K
E
M
I
P
P
--
G
A
L
V
M
L
T
P
L
V
V
G
I
L
F
------
G
V
E
T
L
S
G
V
L
A
G
S
L
V
S
G
V
Q
I
A
I
S
A
S
N
T
G
G
A
W
D
N
A
K
K
Y
I
E
A
GAS
E
H
A
R
S
L
G
PKGS
D
C
H
K
A
A
V
I
G
D
T
I
G
DPLKDT
S
G
P
S
L
N
I
L
I
K
L
M
A
V
E
S
L
V
F
A
P
F
F
A
T
HGG
L
L
F
K
I
F
30
Fugue
68.19
12%
-98
- C2 -
2R6G
1
MALF_ECOLI
F:
[13-504]
---------------------------------------------------------------------------------------
D
A
L
-----
K
W
S
-
V
L
G
L
L
G
L
-
L
V
G
Y
L
V
-
V
-
L
M
Y
----
A
Q
G
E
Y
L
F
A
I
T
T
L
I
L
S
S
A
G
L
Y
I
F
A
N
-
R
K
A
Y
A
W
R
Y
V
Y
P
G
-----
M
A
G
M
G
L
F
V
L
F
P
L
V
C
T
I
---
A
----
I
A
F
T
N
Y
S
S
T
N
Q
L
-
T
F
E
R
A
Q
E
V
L
L
D
R
S
W
Q
A
G
K
T
Y
N
F
G
-
L
Y
P
A
G
D
E
W
Q
L
A
L
S
D
G
E
T
G
K
N
Y
L
S
D
A
F
K
F
--
G
G
-
E
-
Q
K
L
Q
L
K
E
T
T
-
A
Q
P
--
E
G
E
R
A
N
L
R
V
I
T
Q
N
R
Q
A
L
S
D
-----------
I
T
A
I
L
P
D
---
G
N
K
V
--
M
M
--
S
-------------
S
L
R
Q
F
S
G
T
Q
P
L
Y
---
T
L
----
D
G
D
G
T
L
T
N
N
Q
S
G
V
K
Y
R
P
--
N
N
Q
I
G
F
Y
Q
S
I
T
A
N
W
G
D
E
K
L
S
P
G
Y
T
V
T
T
G
W
K
N
F
T
R
V
F
T
D
E
G
-------------------------------------------
I
-
Q
K
P
----
F
-
L
A
I
F
V
W
T
V
V
F
S
L
I
T
V
F
L
T
V
A
V
G
M
V
L
A
C
----
L
-----
V
Q
W
E
---------
A
L
RG
K
A
V
Y
R
V
-
L
L
I
L
P
Y
A
V
P
S
F
I
S
I
L
I
F
K
G
L
--------------
F
N
Q
S
F
G
E
I
N
M
M
L
S
-
A
-----
L
F
G
----
V
K
PAWFSDPTT
A
R
T
M
L
I
I
V
N
T
-
W
L
G
Y
P
Y
M
M
I
L
C
M
G
L
L
K
A
----
I
P
D
D
L
Y
E
A
S
A
M
D
G
A
G
P
F
Q
N
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
M
I
A
S
F
A
F
N
F
N
N
F
V
L
I
Q
L
L
T
N
G
G
------------
P
D
R
L
G
T
T
T
PAGY
T
D
L
L
V
----
N
Y
-
T
Y
R
I
A
F
E
G
GG
G
Q
D
F
G
L
A
A
A
I
A
T
L
I
F
L
L
V
G
A
L
A
I
V
-------------------------------------------------------------------------------------------------------
17
HHSearch
65.09
17%
-122
- C2 -
2ONK
-
WTPB_ARCFU
C:
[34-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
S
S
I
I
L
L
F
V
L
L
---------
P
V
A
A
T
V
T
L
Q
LFN-
F
--
D
E
F
L
K
A
A
S
D
P
A
----
V
-
W
K
V
V
L
T
T
Y
Y
A
A
L
I
S
T
L
I
A
V
I
F
G
T
P
L
A
Y
----
I
-----
L
A
R
K
SF-------
P
G
--
K
S
V
V
E
G
-
I
V
D
L
P
V
V
I
P
H
T
V
A
G
I
A
L
L
V
V
--------------
F
G
S
-
S
G
L
I
G
S
F
S
P
-------
L
K
F
----
V
D
---------
A
L
P
G
I
V
V
A
M
L
-
F
V
S
V
P
I
Y
I
N
Q
A
K
E
G
F
A
S
----
V
D
V
R
L
E
H
V
A
R
T
L
G
S
S
P
L
R
V
F
F
T
V
S
L
P
L
S
V
R
H
I
V
A
G
A
I
M
S
W
A
R
G
I
S
E
F
G
A
V
V
V
I
A
Y
-
Y
------------
P
M
I
A
P
T
L
I
----
Y
E
R
Y
L
----
S
E
-
G
L
S
A
A
M
P
V
--
A
A
I
L
I
L
L
S
L
A
V
F
V
A
L
R
I
I
V
G
-----------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
64.91
22%
-115
- C2 -
2ONK
-
WTPB_ARCFU
C:
[77-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
Y
A
A
L
I
S
T
L
I
A
V
I
F
G
T
----
P
LAYIL
A
R
K
S
---------
F
P
--
G
K
S
V
V
E
G
I
V
D
L
P
V
V
I
P
H
T
V
A
G
I
A
L
L
V
V
--------------
F
G
--
S
S
G
L
I
G
S
F
S
-
P
-----
L
K
F
----
V
D
---------
A
L
P
G
I
V
V
A
M
L
-
F
V
S
V
P
I
Y
I
N
Q
A
K
E
G
F
A
S
----
V
D
V
R
L
E
H
V
A
R
T
L
G
S
S
P
L
R
V
F
F
T
V
S
L
P
L
S
V
R
H
I
V
A
G
A
I
M
S
W
A
R
G
I
S
E
F
G
A
V
V
V
I
A
Y
Y
P
------------
M
-
I
A
P
T
L
I
----
Y
E
R
Y
L
----
S
E
-
G
L
S
A
A
M
P
V
--
A
A
I
L
I
L
L
S
L
A
V
F
V
A
L
R
I
I
V
G
-----------------------------------------------------------------------------------------------------------
20
HHSearch
64.53
19%
-114
* C2 *
3RLF
2
MALF_ECOLI
F:
[262-503]
-----------------------------------------------------------------------------------------------------------
K
N
F
T
R
V
-
F
T
D
E
G
IQKP
F
L
A
I
F
V
W
T
V
V
F
S
L
I
T
V
F
L
T
V
A
V
G
M
V
L
A
C
L
V
Q
W
E
A
L
R
G
-----
K
A
V
Y
R
V
L
L
I
L
P
Y
A
V
P
S
---
F
----
I
S
I
L
I
F
K
G
L
F
N
Q
S
F
G
E
I
N
M
M
L
S
A
L
F
G
V
K
--
P
A
W
F
S
D
P
T
T
A
R
T
M
L
I
I
V
N
T
W
L
G
Y
P
Y
M
M
I
L
C
M
G
L
L
K
--
A
I
-
P
D
D
L
Y
E
A
S
A
M
D
-
G
A
G
--
P
F
Q
N
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
M
I
A
S
---
F
A
F
N
F
N
N
F
V
L
---
I
Q
L
L
--
T
N
GG
P
DRLGTTTPAGYTD
L
L
V
N
Y
T
Y
R
I
A
F
E
GGG
G
Q
----
D
F
G
L
A
A
A
I
A
T
L
I
F
L
L
V
G
A
L
A
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Fugue
64.13
14%
-125
- C2 -
3FH6
-
MALG_ECOLI
G:
[3-287]
------------------------------------------------------------MVQPKSQ
K
A
R
L
F
I
T
H
L
L
L
L
L
F
I
A
A
I
M
F
P
L
L
-----
M
V
V
-
A
I
S
L
R
Q
R
-
I
T
P
P
-----
P
F
P
----
V
L
L
W
L
W
N
S
V
K
V
A
G
I
S
A
I
G
I
V
A
L
S
T
T
C
A
Y
A
F
A
R
M
R
F
P
G
-----
K
A
T
L
L
K
G
M
L
I
F
Q
M
F
P
A
VLS
L
----
V
A
L
Y
A
L
F
D
R
L
G
E
-
Y
I
P
F
I
G
L
-------------------
N
T
H
G
G
V
I
F
A
Y
L
G
G
I
A
L
H
V
W
T
I
K
G
Y
F
E
--
T
I
-
D
-
S
S
L
E
E
A
A
A
L
D
G
A
T
--
P
W
Q
A
F
R
L
V
L
L
P
L
S
V
P
I
L
A
V
V
F
I
L
S
---
F
I
A
A
I
T
E
V
P
V
---
A
S
L
L
LR
D
V
--
N
-------------
S
Y
T
L
A
V
G
M
Q
Q
Y
L
---
N
P
----
Q
N
Y
L
W
G
D
F
A
A
A
A
V
M
S
A
L
P
I
T
I
V
F
L
L
A
Q
R
W
L
V
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
64.11
14%
-105
- C2 -
3RLF
2
MALF_ECOLI
F:
[256-503]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
T
T
G
----
W
--
K
N
F
T
R
V
F
T
D
E
G
IQKP
F
-
L
A
I
F
V
W
T
V
V
F
S
L
I
T
V
F
L
T
V
A
V
G
M
V
L
A
C
----
L
-----
V
Q
W
E
AL-------
R
G
--
K
A
V
Y
R
V
-
L
L
I
L
P
Y
A
V
P
S
F
I
S
I
L
I
F
K
G
L
--------------
F
N
Q
S
F
G
E
I
N
M
M
L
S
-
A
LFGVK
P
A
W
FSDP
T
T
---------
A
R
T
M
L
I
I
V
N
T
-
W
L
G
Y
P
Y
M
M
I
L
C
M
G
L
L
K
A
----
I
P
D
D
L
Y
E
A
S
A
M
D
G
A
G
P
F
Q
N
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
M
I
A
S
F
A
F
N
F
N
N
F
V
L
I
Q
L
L
T
N
G
G
PDRLGTTTPAGY
T
D
L
L
V
N
Y
T
----
Y
R
I
A
F
EGGG
G
Q
-
D
F
G
L
A
A
A
I
--
A
T
L
I
F
L
L
V
G
A
L
A
I
------------------------------------------------------------------------------------------------------------------
18
HHSearch
62.57
18%
-119
- C2 -
3D31
-
?
C:
[43-283]
---------------------------------------------------------------------------
F
L
L
L
V
L
F
L
F
I
F
L
T
L
S
-----
N
M
I
-
F
E
Q
I
T
E
D
F
S
G
L
V
K
A
A
G
-
N
R
S
----
V
I
S
S
I
F
L
S
L
Y
A
G
F
L
A
T
L
L
A
L
L
L
G
A
P
T
G
Y
I
L
A
R
F
D
F
P
G
-----
K
R
L
V
E
S
I
I
D
V
P
V
V
V
P
H
---
T
----
V
A
G
I
A
L
L
T
V
F
G
S
-
R
G
L
I
G
E
P
L
E
S
Y
---------
I
Q
F
-
R
D
A
L
P
G
I
V
V
A
M
L
F
V
S
M
P
Y
L
A
N
S
A
R
E
G
F
K
--
S
V
-
D
P
R
L
E
N
A
A
R
S
L
-
G
A
P
--
L
W
K
A
F
F
F
V
T
L
P
L
S
A
R
Y
L
L
I
G
S
V
M
T
---
W
A
R
A
I
S
E
F
G
A
---
V
V
I
L
--
A
Y
YP
M
-------------
V
G
P
T
L
I
Y
D
R
F
I
S
----
Y
----
G
L
S
A
S
R
P
I
A
V
L
L
I
L
V
T
L
S
I
F
L
V
I
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
62.15
14%
-118
- C2 -
3D31
-
?
C:
[48-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
L
F
I
F
L
---------
T
L
S
N
M
I
F
E
Q
ITED
F
--
S
G
L
V
K
A
A
G
N
R
S
----
V
-
I
S
S
I
F
L
S
L
Y
A
G
F
L
A
T
L
L
A
L
L
L
G
A
P
T
G
Y
----
I
-----
L
A
R
F
DF-------
P
G
--
K
R
L
V
E
S
-
I
I
D
V
P
V
V
V
P
H
T
V
A
G
I
A
L
L
T
V
--------------
F
G
S
-
R
G
L
I
G
E
P
L
E
S
Y
-----
I
Q
F
----
R
D
---------
A
L
P
G
I
V
V
A
M
L
-
F
V
S
M
P
Y
L
A
N
S
A
R
E
G
F
K
S
----
V
D
P
R
L
E
N
A
A
R
S
L
G
A
P
L
W
K
A
F
F
F
V
T
L
P
L
S
A
R
Y
L
L
I
G
S
V
M
T
W
A
R
A
I
S
E
F
G
A
V
V
I
L
A
Y
-
Y
------------
P
M
V
G
P
T
L
I
----
Y
D
R
F
I
----
S
Y
-
G
L
S
A
S
R
P
I
--
A
V
L
L
I
L
V
T
L
S
I
F
L
V
I
R
---------------------------------------------------------------------------------------------------------------
23
HHSearch
60.18
11%
-100
- C2 -
3TUI
-
METI_ECOLI
A:
[7-216]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
L
----
L
-
V
R
G
V
W
E
T
L
A
M
T
F
V
S
G
F
F
G
F
V
I
G
L
P
V
G
V
----
L
-----
L
Y
V
T
RPGQIIAN
A
K
L
--
Y
R
T
V
S
A
-
I
V
N
I
F
R
S
I
P
F
I
I
L
L
V
W
M
I
P
F
--------------
T
R
V
I
V
----------------
G
T
----
S
I
---------
G
L
Q
A
A
I
V
P
L
T
-
V
G
A
A
P
F
I
A
R
M
V
E
N
A
L
L
E
----
I
P
T
G
L
I
E
A
S
R
A
M
G
A
T
P
M
Q
I
V
R
K
V
L
L
P
E
A
L
P
G
L
V
N
A
A
T
I
T
L
I
T
L
V
G
Y
S
A
M
G
G
A
V
G
---------------
A
G
G
L
G
Q
I
G
----
Y
Q
Y
G
Y
----
I
G
Y
N
A
T
V
M
N
T
V
--
L
V
L
L
V
I
L
V
Y
L
I
Q
F
A
G
D
R
I
V
R
A
V
T
R
-------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
58.41
22%
-125
- C2 -
2R6G
1
MALF_ECOLI
F:
[277-426]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-
L
A
I
F
V
W
T
V
V
F
S
L
I
T
V
F
L
T
V
A
V
G
M
V
L
A
C
LVQW
E
-----
A
L
R
G
---------
K
A
--
V
Y
R
V
---
L
L
I
L
P
Y
A
V
P
S
F
---
I
S
I
L
I
F
KGLFNQSFGEINMM
L
S
A
L
F
G
V
K
P
A
W
F
S
-
D
-----
P
T
T
----
A
R
---------
T
M
L
I
I
V
N
T
W
L
G
Y
P
Y
M
M
I
L
C
M
G
L
---
L
K
A
----
I
P
D
D
L
Y
E
A
S
A
M
D
G
A
G
P
F
Q
N
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
M
I
A
S
F
A
F
N
F
N
N
F
V
L
I
Q
L
L
T
N
G
G
------------
P
D
R
L
G
T
T
T
----
P
A
G
Y
T
----
D
L
-
L
V
N
Y
T
Y
R
I
--
A
F
E
G
G
G
G
Q
D
F
G
L
A
A
A
I
A
T
L
I
F
L
L
V
-------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
58.21
22%
-128
- C2 -
4KHZ
2
MALF_ECOLI
F:
[277-426]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-
L
A
I
F
V
W
T
V
V
F
S
L
I
T
V
F
L
T
V
A
V
G
M
V
L
A
C
LVQW
E
-----
A
L
R
G
---------
K
A
--
V
Y
R
V
---
L
L
I
L
P
Y
A
V
P
S
F
---
I
S
I
L
I
F
KGLFNQSFGEINMM
L
S
A
L
F
G
V
K
P
A
W
F
S
-
D
-----
P
T
T
----
A
R
---------
T
M
L
I
I
V
N
T
W
L
G
Y
P
Y
M
M
I
L
C
M
G
L
---
L
K
A
----
I
P
D
D
L
Y
E
A
S
A
M
D
G
A
G
P
F
Q
N
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
M
I
A
S
F
A
F
N
F
N
N
F
V
L
I
Q
L
L
T
N
G
G
------------
P
D
R
L
G
T
T
T
----
P
A
G
Y
T
----
D
L
-
L
V
N
Y
T
Y
R
I
--
A
F
E
G
G
G
G
Q
D
F
G
L
A
A
A
I
A
T
L
I
F
L
L
V
-------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
57.72
22%
-126
- C2 -
3PUY
2
MALF_ECOLI
F:
[277-426]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-
L
A
I
F
V
W
T
V
V
F
S
L
I
T
V
F
L
T
V
A
V
G
M
V
L
A
C
LVQW
E
-----
A
L
R
G
---------
K
A
--
V
Y
R
V
---
L
L
I
L
P
Y
A
V
P
S
F
---
I
S
I
L
I
F
KGLFNQSFGEINMM
L
S
A
L
F
G
V
K
P
A
W
F
S
-
D
-----
P
T
T
----
A
R
---------
T
M
L
I
I
V
N
T
W
L
G
Y
P
Y
M
M
I
L
C
M
G
L
---
L
K
A
----
I
P
D
D
L
Y
E
A
S
A
M
D
G
A
G
P
F
Q
N
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
M
I
A
S
F
A
F
N
F
N
N
F
V
L
I
Q
L
L
T
N
G
G
------------
P
D
R
L
G
T
T
T
----
P
A
G
Y
T
----
D
L
-
L
V
N
Y
T
Y
R
I
--
A
F
E
G
G
G
G
Q
D
F
G
L
A
A
A
I
A
T
L
I
F
L
L
V
-------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
57.67
22%
-128
- C2 -
3PV0
2
MALF_ECOLI
F:
[277-426]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-
L
A
I
F
V
W
T
V
V
F
S
L
I
T
V
F
L
T
V
A
V
G
M
V
L
A
C
LVQW
E
-----
A
L
R
G
---------
K
A
--
V
Y
R
V
---
L
L
I
L
P
Y
A
V
P
S
F
---
I
S
I
L
I
F
KGLFNQSFGEINMM
L
S
A
L
F
G
V
K
P
A
W
F
S
-
D
-----
P
T
T
----
A
R
---------
T
M
L
I
I
V
N
T
W
L
G
Y
P
Y
M
M
I
L
C
M
G
L
---
L
K
A
----
I
P
D
D
L
Y
E
A
S
A
M
D
G
A
G
P
F
Q
N
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
M
I
A
S
F
A
F
N
F
N
N
F
V
L
I
Q
L
L
T
N
G
G
------------
P
D
R
L
G
T
T
T
----
P
A
G
Y
T
----
D
L
-
L
V
N
Y
T
Y
R
I
--
A
F
E
G
G
G
G
Q
D
F
G
L
A
A
A
I
A
T
L
I
F
L
L
V
-------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
56.92
22%
-128
- C2 -
3PUZ
2
MALF_ECOLI
F:
[277-426]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-
L
A
I
F
V
W
T
V
V
F
S
L
I
T
V
F
L
T
V
A
V
G
M
V
L
A
C
LVQW
E
-----
A
L
R
G
---------
K
A
--
V
Y
R
V
---
L
L
I
L
P
Y
A
V
P
S
F
---
I
S
I
L
I
F
KGLFNQSFGEINMM
L
S
A
L
F
G
V
K
P
A
W
F
S
-
D
-----
P
T
T
----
A
R
---------
T
M
L
I
I
V
N
T
W
L
G
Y
P
Y
M
M
I
L
C
M
G
L
---
L
K
A
----
I
P
D
D
L
Y
E
A
S
A
M
D
G
A
G
P
F
Q
N
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
M
I
A
S
F
A
F
N
F
N
N
F
V
L
I
Q
L
L
T
N
G
G
------------
P
D
R
L
G
T
T
T
----
P
A
G
Y
T
----
D
L
-
L
V
N
Y
T
Y
R
I
--
A
F
E
G
G
G
G
Q
D
F
G
L
A
A
A
I
A
T
L
I
F
L
L
V
-------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
56.74
22%
-122
- C2 -
3PUV
3
MALF_ECOLI
F:
[277-426]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-
L
A
I
F
V
W
T
V
V
F
S
L
I
T
V
F
L
T
V
A
V
G
M
V
L
A
C
LVQW
E
-----
A
L
R
G
---------
K
A
--
V
Y
R
V
---
L
L
I
L
P
Y
A
V
P
S
F
---
I
S
I
L
I
F
KGLFNQSFGEINMM
L
S
A
L
F
G
V
K
P
A
W
F
S
-
D
-----
P
T
T
----
A
R
---------
T
M
L
I
I
V
N
T
W
L
G
Y
P
Y
M
M
I
L
C
M
G
L
---
L
K
A
----
I
P
D
D
L
Y
E
A
S
A
M
D
G
A
G
P
F
Q
N
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
L
M
I
A
S
F
A
F
N
F
N
N
F
V
L
I
Q
L
L
T
N
G
G
------------
P
D
R
L
G
T
T
T
----
P
A
G
Y
T
----
D
L
-
L
V
N
Y
T
Y
R
I
--
A
F
E
G
G
G
G
Q
D
F
G
L
A
A
A
I
A
T
L
I
F
L
L
V
-------------------------------------------------------------------------------------------------------