@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0041: (2015-11-27 )
MSKSDILCKRVIGIVGSGQLGKMTAIAATKLGQETHIFANAKDDPACSVANNLTIADFSDKKALESFAQSVSLVTIESENIPCDAIDIMSQYVDFYPGKRALHISQNRLREKDFIRNLGIRTADYKSIQDHNDLLEVTRAFGYPTRLKTTEMGYDGKGQYMIGNDSQVERFASFDWNAQYILEASVDLLKEVSIVVTRDKNGKVAFFPVAENHHVDGILDTSIVPAKVDSKLVQEIQQTAEKIADALDVVGILAIEFFITKNSELLVNELAPRPHNSCHWSLDACNVSQFEQLIRVICKLPMQEVVLRFPCMTKNIIGNDVYNTYKYLSDKRANLTIYGKKEVRGRRKMGHVNIDLS
Atome Classification :
(27 SA)
.........10........20........30........40........50........60........70........80......-..-90-...-......100.......110.......120.......130.......140---.......150........160.......170..--.....180.......-190.......200.......210.......220.....-.-.230..-.....240.......250.......260.......270.......280.......290......--.300.......-310.......-------------320.-------..-----..---.--..330.-......340.......350.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
K
S
D
I
L
C
K
R
V
I
G
IVGSGQLG
K
M
T
A
I
A
ATKLGQE
T
H
I
F
A
NAKDDPACSVAN
N
L
T
IADFS
D
K
K
A
L
E
S
F
A
QS
V
S
L
V
T
I
ESENIPC
D
A
I
D
-
I
M
-
S
--
Q
Y
V
-
D
FYPG
K
R
A
L
HI
S
Q
N
RL
R
E
K
D
F
I
R
NLGIRTADYKSIQD
H
N
D
L
L
E
V
T
R
AFG---YPTRL
K
T
T-EMGYDGKG
Q
Y
M
IG
N
D
S
Q
V
E
R
F
ASF--DWN
A
Q
Y
I
L
E
A
S
V
D
L
L
-
K
E
V
S
I
V
V
T
RDKNG
K
V
A
F
F
PVAENHHVD
G
I
LDTSIVPAK-
V
-
D
S
K
L
V
Q
-
E
I
Q
Q
T
A
E
K
I
A
D
A
L
D
V
V
G
I
L
A
I
E
F
F
ITKNS
E
L
L
V
N
E
LAPRPHNS
C
H
W
SLDAC
N
V
S
Q
F
E
Q
L
I
R
V
I
C
--KL
P
M
Q
E
V
V
L
RF-PCM
T
K
N
I
IGN-------------
D
V
-
Y
-------
N
T
-----
Y
K
---
Y
--
L
SDKRA-
N
L
T
I
Y
G
K
K
EVRGRRKMG
H
V
N
I
DLS
31
HHSearch
95.70
41%
-87
- C1 -
3Q2O
1
?
A:
[9-363]
---
R
I
I
L
P
G
K
T
I
G
I
I
G
G
G
Q
L
G
R
M
M
A
L
A
A
K
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Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
A
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I
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I
V
A
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Y
D
D
L
K
A
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Q
H
L
A
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D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
-
W
L
-
E
K
H
A
Y
L
---
P
Q
G
S
Q
L
L
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Q
N
R
F
T
E
K
N
A
I
E
K
A
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L
P
V
A
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Y
R
L
V
Q
N
Q
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Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
--
A
N
A
A
E
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
R
-
I
-
T
E
E
L
S
Q
-
K
A
I
A
Y
A
K
V
L
A
D
E
L
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L
V
G
T
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M
F
A
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A
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T
Q
D
A
C
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T
S
Q
F
G
Q
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R
A
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--
N
L
P
L
G
E
T
N
L
L
K
-
P
V
V
M
V
N
I
L
G
E
-------------
H
I
-
E
-------
G
V
-----
L
R
---
Q
V
-
N
R
L
T
G
C
-
Y
L
H
L
Y
G
K
E
E
A
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
6
PsiBlast_PDB
90.60
35%
-84
- C1 -
4E4T
3
?
A:
[29-395]
--
V
S
P
I
L
P
G
A
W
L
G
M
V
G
G
G
Q
L
G
R
M
F
C
F
A
A
Q
S
M
G
Y
R
V
A
V
L
D
P
D
P
A
S
P
A
G
A
V
A
D
R
H
L
R
A
A
Y
D
D
E
A
A
L
A
E
L
A
G
L
C
E
A
V
S
T
E
F
E
N
V
P
A
A
S
L
D
-
F
L
-
A
--
R
T
T
-
F
V
A
P
A
G
R
C
V
A
V
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R
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K
R
F
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A
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V
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V
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A
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A
L
A
A
L
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D
A
A
L
D
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V
L
P
G
I
L
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T
A
-
R
L
G
Y
D
G
K
G
Q
V
R
V
S
T
A
R
E
A
R
D
A
H
A
A
--
L
G
G
V
P
C
V
L
E
K
R
L
P
L
K
-
Y
E
V
S
A
L
I
A
R
G
A
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G
R
S
A
A
F
P
L
A
Q
N
V
H
H
N
G
I
L
A
L
T
I
V
P
A
P
-
A
A
D
T
A
R
V
E
-
E
A
Q
Q
A
A
V
R
I
A
D
T
L
G
Y
V
G
V
L
C
V
E
F
F
V
L
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D
G
S
F
V
A
N
E
M
A
P
R
P
H
N
S
G
H
Y
T
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D
A
C
A
T
S
Q
F
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Q
Q
V
R
A
M
T
--
R
M
P
L
G
N
P
R
Q
H
S
-
P
A
A
M
L
N
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L
G
D
VWFPNGAAA
G
A
V
T
P
P
-
W
-------
D
T
-----
V
A
---
A
--
M
--
P
A
A
-
H
L
H
L
Y
G
K
E
E
A
R
V
G
R
K
M
G
H
V
N
F
T
A
E
34
HHSearch
90.30
35%
-92
- C1 -
3AX6
1
?
A:
[1-352]
--------
M
K
K
I
G
I
I
G
G
G
Q
L
G
K
M
M
T
L
E
A
K
K
M
G
F
Y
V
I
V
L
D
P
T
P
R
S
P
A
G
Q
V
A
D
E
Q
I
V
A
G
F
F
D
S
E
R
I
E
D
L
V
K
G
S
D
V
T
T
Y
D
L
E
H
I
D
V
Q
T
L
K
-
K
L
-
Y
N
-
E
G
Y
-
K
I
H
P
S
P
Y
T
L
E
I
I
Q
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K
F
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K
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F
L
K
K
N
G
I
P
V
P
E
Y
K
L
V
K
D
L
E
S
---
D
V
R
E
F
G
---
F
P
V
V
Q
K
A
R
-
K
G
-----
G
V
F
I
I
K
N
E
K
D
L
E
N
A
I
K
------
G
E
T
Y
L
E
E
F
V
E
-
I
E
K
E
L
A
V
M
V
A
R
N
E
K
G
E
I
A
C
Y
P
V
V
E
M
Y
------
D
T
V
I
A
P
A
R
-
I
-
E
E
K
Y
S
K
-
I
A
R
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I
A
T
S
V
V
E
A
L
E
G
V
G
I
F
G
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M
F
L
T
K
Q
G
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L
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N
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A
P
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H
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T
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A
C
V
T
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Q
F
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Q
H
I
R
A
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M
--
N
L
P
L
G
S
T
E
L
L
I
-
P
A
V
M
V
N
L
L
G
E
----------------
E
-------
G
Y
Y
G
K
P
A
L
I
G
L
E
E
A
-
L
A
I
E
G
L
-
S
L
H
F
Y
G
K
K
E
T
R
P
Y
R
K
M
G
H
F
T
V
V
D
R
23
PsiBlast_CBE
90.30
40%
-86
- C1 -
3QFF
1
?
B:
[24-360]
------------------
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
A
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
-
W
L
-
E
--
K
H
A
-
Y
L
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
--
A
N
A
A
E
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
R
-
I
-
T
E
E
L
S
Q
-
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
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M
F
A
T
A
D
G
E
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Y
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N
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L
A
P
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P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
--
N
L
P
L
G
E
T
N
L
L
K
-
P
V
V
M
V
N
I
L
G
E
-------------
H
I
-
E
-------
G
V
-----
L
R
---
Q
--
V
N
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
1
PsiBlast_PDB
89.93
40%
-85
- C1 -
3Q2O
1
?
A:
[24-360]
------------------
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
A
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
-
W
L
-
E
--
K
H
A
-
Y
L
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
--
A
N
A
A
E
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
R
-
I
-
T
E
E
L
S
Q
-
K
A
I
A
Y
A
K
V
L
A
D
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L
E
L
V
G
T
L
A
V
E
M
F
A
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A
D
G
E
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Y
I
N
E
L
A
P
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P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
--
N
L
P
L
G
E
T
N
L
L
K
-
P
V
V
M
V
N
I
L
G
E
-------------
H
I
-
E
-------
G
V
-----
L
R
---
Q
--
V
N
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
25
PsiBlast_CBE
89.91
40%
-86
- C1 -
4DLK
4
?
B:
[18-354]
------------------
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
A
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
-
W
L
-
E
--
K
H
A
-
Y
L
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
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K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
--
A
N
A
A
E
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
R
-
I
-
T
E
E
L
S
Q
-
K
A
I
A
Y
A
K
V
L
A
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E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
--
N
L
P
L
G
E
T
N
L
L
K
-
P
V
V
M
V
N
I
L
G
E
-------------
H
I
-
E
-------
G
V
-----
L
R
---
Q
--
V
N
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
5
PsiBlast_PDB
89.85
40%
-83
- C1 -
4DLK
7
?
A:
[18-354]
------------------
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
A
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
-
W
L
-
E
--
K
H
A
-
Y
L
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
--
A
N
A
A
E
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
R
-
I
-
T
E
E
L
S
Q
-
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
--
N
L
P
L
G
E
T
N
L
L
K
-
P
V
V
M
V
N
I
L
G
E
-------------
H
I
-
E
-------
G
V
-----
L
R
---
Q
--
V
N
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
2
PsiBlast_PDB
89.63
40%
-85
- C1 -
3QFF
1
?
A:
[24-360]
------------------
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
A
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
-
W
L
-
E
--
K
H
A
-
Y
L
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
--
A
N
A
A
E
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
R
-
I
-
T
E
E
L
S
Q
-
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
--
N
L
P
L
G
E
T
N
L
L
K
-
P
V
V
M
V
N
I
L
G
E
-------------
H
I
-
E
-------
G
V
-----
L
R
---
Q
--
V
N
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
21
PsiBlast_CBE
89.61
40%
-85
- C1 -
3V4S
4
?
B:
[24-360]
------------------
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
A
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
-
W
L
-
E
--
K
H
A
-
Y
L
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
--
A
N
A
A
E
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
R
-
I
-
T
E
E
L
S
Q
-
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
--
N
L
P
L
G
E
T
N
L
L
K
-
P
V
V
M
V
N
I
L
G
E
-------------
H
I
-
E
-------
G
V
-----
L
R
---
Q
--
V
N
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
24
PsiBlast_CBE
89.48
40%
-85
- C1 -
3Q2O
1
?
B:
[24-360]
------------------
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
A
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
-
W
L
-
E
--
K
H
A
-
Y
L
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
--
A
N
A
A
E
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
R
-
I
-
T
E
E
L
S
Q
-
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
--
N
L
P
L
G
E
T
N
L
L
K
-
P
V
V
M
V
N
I
L
G
E
-------------
H
I
-
E
-------
G
V
-----
L
R
---
Q
--
V
N
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
3
PsiBlast_PDB
88.98
40%
-82
- C1 -
3R5H
3
?
A:
[24-360]
------------------
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
A
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
-
W
L
-
E
--
K
H
A
-
Y
L
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
--
A
N
A
A
E
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
R
-
I
-
T
E
E
L
S
Q
-
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
--
N
L
P
L
G
E
T
N
L
L
K
-
P
V
V
M
V
N
I
L
G
E
-------------
H
I
-
E
-------
G
V
-----
L
R
---
Q
--
V
N
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
26
PsiBlast_CBE
88.84
35%
-89
- C1 -
4E4T
2
?
B:
[30-395]
---
S
P
I
L
P
G
A
W
L
G
M
V
G
G
G
Q
L
G
R
M
F
C
F
A
A
Q
S
M
G
Y
R
V
A
V
L
D
P
D
P
A
S
P
A
G
A
V
A
D
R
H
L
R
A
A
Y
D
D
E
A
A
L
A
E
L
A
G
L
C
E
A
V
S
T
E
F
E
N
V
P
A
A
S
L
D
-
F
L
-
A
--
R
T
T
-
F
V
A
P
A
G
R
C
V
A
V
A
Q
D
R
I
A
E
K
R
F
I
E
A
S
G
V
P
V
A
P
H
V
V
I
E
S
A
A
A
L
A
A
L
D
D
A
A
L
D
A
V
L
P
G
I
L
K
T
A
-
R
-----
K
G
Q
V
R
V
S
T
A
R
E
A
R
D
A
H
A
A
--
L
G
G
V
P
C
V
L
E
K
R
L
P
L
K
-
Y
E
V
S
A
L
I
A
R
G
A
D
G
R
S
A
A
F
P
L
A
Q
N
V
H
H
N
G
I
L
A
L
T
I
V
P
A
P
-
A
A
D
T
A
R
V
E
-
E
A
Q
Q
A
A
V
R
I
A
D
T
L
G
Y
V
G
V
L
C
V
E
F
F
V
L
E
D
G
S
F
V
A
N
E
M
A
P
R
P
H
N
S
G
H
Y
T
V
D
A
C
A
T
S
Q
F
E
Q
Q
V
R
A
M
T
--
R
M
P
L
G
N
P
R
Q
H
S
-
P
A
A
M
L
N
I
L
G
D
VWFPNGAAA
G
A
V
T
P
P
-
W
-------
D
T
-----
V
A
---
A
--
M
--
P
A
A
-
H
L
H
L
Y
G
K
E
E
A
R
V
G
R
K
M
G
H
V
N
F
T
A
E
32
HHSearch
88.51
38%
-90
- C1 -
3AW8
2
?
A:
[1-344]
----------
M
I
G
I
L
G
G
G
Q
L
G
R
M
L
A
L
A
G
Y
P
L
G
L
S
F
R
F
L
D
P
S
P
E
A
C
A
G
Q
V
G
E
-
L
V
V
G
E
F
L
D
E
G
A
L
L
R
F
A
E
G
L
A
L
V
T
Y
E
F
E
N
V
P
V
E
A
A
R
-
R
L
-
E
--
G
R
L
-
P
L
Y
P
P
A
K
A
L
E
V
A
Q
D
R
L
R
E
K
T
F
F
Q
G
L
G
V
P
T
P
P
F
H
P
V
D
G
P
E
D
L
E
E
G
L
K
R
V
G
---
L
P
A
L
L
K
T
R
-
R
G
------
Q
A
L
V
R
T
E
E
E
A
L
E
A
L
K
A
--
L
G
G
R
G
L
I
L
E
G
F
V
P
F
D
-
R
E
V
S
L
L
A
V
R
G
R
T
G
E
V
A
F
Y
P
L
V
E
N
R
H
W
G
G
I
L
R
L
S
L
A
P
A
P
G
A
-
S
E
A
L
Q
K
-
K
A
E
A
Y
A
L
R
A
M
E
A
L
D
Y
V
G
V
L
A
L
E
F
F
Q
V
G
-
E
E
L
L
F
N
E
M
A
P
R
V
H
N
S
G
H
W
T
I
E
G
A
E
T
S
Q
F
E
N
H
L
R
A
V
L
--
G
L
P
L
G
S
T
A
P
R
G
-
Q
S
A
M
V
N
L
I
G
--------------
E
K
-
P
-------
P
------
F
A
---
E
V
-
L
K
V
E
G
A
-
H
L
H
W
Y
G
K
A
-
V
R
P
G
R
K
V
G
H
I
T
L
R
R
D
4
PsiBlast_PDB
88.48
40%
-81
- C1 -
3V4S
3
?
A:
[24-360]
------------------
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
A
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
-
W
L
-
E
--
K
H
A
-
Y
L
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
--
A
N
A
A
E
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
R
-
I
-
T
E
E
L
S
Q
-
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
--
N
L
P
L
G
E
T
N
L
L
K
-
P
V
V
M
V
N
I
L
G
E
-------------
H
I
-
E
-------
G
V
-----
L
R
---
Q
--
V
N
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
22
PsiBlast_CBE
87.57
40%
-84
- C1 -
3R5H
3
?
B:
[24-360]
------------------
Q
L
G
R
M
M
A
L
A
A
K
E
M
G
Y
K
I
A
V
L
D
P
T
K
N
S
P
C
A
Q
V
A
D
I
E
I
V
A
S
Y
D
D
L
K
A
I
Q
H
L
A
E
I
S
D
V
V
T
Y
E
F
E
N
I
D
Y
R
C
L
Q
-
W
L
-
E
--
K
H
A
-
Y
L
P
Q
G
S
Q
L
L
S
K
T
Q
N
R
F
T
E
K
N
A
I
E
K
A
G
L
P
V
A
T
Y
R
L
V
Q
N
Q
E
Q
L
T
E
A
I
A
E
L
S
---
Y
P
S
V
L
K
T
T
-
T
G
G
Y
D
G
K
G
Q
V
V
L
R
S
E
A
D
V
D
E
A
R
K
L
--
A
N
A
A
E
C
I
L
E
K
W
V
P
F
E
-
K
E
V
S
V
I
V
I
R
S
V
S
G
E
T
K
V
F
P
V
A
E
N
I
H
V
N
N
I
L
H
E
S
I
V
P
A
R
-
I
-
T
E
E
L
S
Q
-
K
A
I
A
Y
A
K
V
L
A
D
E
L
E
L
V
G
T
L
A
V
E
M
F
A
T
A
D
G
E
I
Y
I
N
E
L
A
P
R
P
H
N
S
G
H
Y
T
Q
D
A
C
E
T
S
Q
F
G
Q
H
I
R
A
I
C
--
N
L
P
L
G
E
T
N
L
L
K
-
P
V
V
M
V
N
I
L
G
E
-------------
H
I
-
E
-------
G
V
-----
L
R
---
Q
--
V
N
R
L
T
G
C
Y
L
H
L
Y
G
K
E
E
A
K
A
Q
R
K
M
G
H
V
N
I
L
N
D
14
PsiBlast_PDB
85.35
36%
-85
- C1 -
4M9U
12
?
A:
[3-344]
-----------
I
G
I
I
G
A
G
Q
L
A
R
M
L
S
L
A
G
T
P
L
G
L
E
F
H
C
L
G
K
-
N
G
D
C
A
E
E
V
V
K
T
V
T
D
I
E
L
T
K
V
N
D
V
V
A
W
A
K
Q
F
D
V
I
T
F
E
N
E
N
I
S
H
E
L
I
K
-
A
I
-
N
--
H
E
V
-
S
V
Y
P
S
A
K
A
I
A
I
S
Q
D
R
L
L
E
K
S
F
M
Q
D
H
G
I
A
T
A
K
F
V
N
I
D
S
L
A
K
L
Q
S
A
V
D
D
H
G
---
L
P
A
I
L
K
T
R
-
R
F
G
Y
D
G
K
G
Q
F
V
I
R
S
Q
E
D
I
T
K
A
W
D
V
LK
D
A
P
D
G
L
I
Y
E
A
F
V
D
F
D
-
Y
E
V
S
Q
I
C
T
A
D
L
K
G
N
I
A
F
Y
P
L
A
R
N
T
H
K
Q
G
I
I
V
E
S
E
A
P
F
E
---
N
V
V
L
A
E
-
K
A
Q
Q
I
A
K
I
L
V
K
E
F
A
Y
V
G
T
L
A
I
E
F
F
V
-
K
G
D
E
L
I
V
N
E
I
A
P
R
V
H
N
S
G
H
W
S
I
D
G
A
V
T
S
Q
F
E
N
H
V
R
A
I
A
--
G
L
I
L
G
D
T
T
S
R
K
-
T
V
M
L
N
C
I
G
G
M
-------------
P
A
-
T
-------
K
D
-----
L
A
---
A
--
L
D
--
R
V
-
K
I
H
S
Y
-
N
K
E
P
R
K
G
R
K
V
G
H
L
N
L
N
L
N
13
PsiBlast_PDB
85.28
36%
-86
- C1 -
4MAM
3
?
A:
[3-344]
-----------
I
G
I
I
G
A
G
Q
L
A
R
M
L
S
L
A
G
T
P
L
G
L
E
F
H
C
L
G
K
-
N
G
D
C
A
E
E
V
V
K
T
V
T
D
I
E
L
T
K
V
N
D
V
V
A
W
A
K
Q
F
D
V
I
T
F
E
N
E
N
I
S
H
E
L
I
K
-
A
I
-
N
--
H
E
V
-
S
V
Y
P
S
A
K
A
I
A
I
S
Q
D
R
L
L
E
K
S
F
M
Q
D
H
G
I
A
T
A
K
F
V
N
I
D
S
L
A
K
L
Q
S
A
V
D
D
H
G
---
L
P
A
I
L
K
T
R
-
R
F
G
Y
D
G
K
G
Q
F
V
I
R
S
Q
E
D
I
T
K
A
W
D
V
LK
D
A
P
D
G
L
I
Y
E
A
F
V
D
F
D
-
Y
E
V
S
Q
I
C
T
A
D
L
K
G
N
I
A
F
Y
P
L
A
R
N
T
H
K
Q
G
I
I
V
E
S
E
A
P
F
E
---
N
V
V
L
A
E
-
K
A
Q
Q
I
A
K
I
L
V
K
E
F
A
Y
V
G
T
L
A
I
E
F
F
V
-
K
G
D
E
L
I
V
N
E
I
A
P
R
V
H
N
S
G
H
W
S
I
D
G
A
V
T
S
Q
F
E
N
H
V
R
A
I
A
--
G
L
I
L
G
D
T
T
S
R
K
-
T
V
M
L
N
C
I
G
G
M
-------------
P
A
-
T
-------
K
D
-----
L
A
---
A
--
L
D
--
R
V
-
K
I
H
S
Y
-
N
K
E
P
R
K
G
R
K
V
G
H
L
N
L
N
L
N
15
PsiBlast_PDB
85.11
32%
-98
- C1 -
3AX6
1
?
A:
[18-349]
-------------------------
L
E
A
K
K
M
G
F
Y
V
I
V
L
D
P
T
P
R
S
P
A
G
Q
V
A
D
E
Q
I
V
A
G
F
F
D
S
E
R
I
E
D
L
V
K
G
S
D
V
T
T
Y
D
L
E
H
I
D
V
Q
T
L
K
K
L
Y
-
N
--
E
G
Y
-
K
I
H
P
S
P
Y
T
L
E
I
I
Q
D
K
F
V
Q
K
E
F
L
K
K
N
G
I
P
V
P
E
Y
K
L
V
K
D
---
L
E
S
D
V
R
E
F
G
---
F
P
V
V
Q
K
A
R
-
K
G
-----
G
V
F
I
I
K
N
E
K
D
L
E
N
------
A
I
K
G
E
T
Y
L
E
E
F
V
E
I
E
-
K
E
L
A
V
M
V
A
R
N
E
K
G
E
I
A
C
Y
P
V
V
E
M
Y
------
D
T
V
I
A
P
A
R
-
I
-
E
E
K
Y
S
K
-
I
A
R
E
I
A
T
S
V
V
E
A
L
E
G
V
G
I
F
G
I
E
M
F
L
T
K
Q
G
E
I
L
V
N
E
I
A
P
R
P
H
N
S
G
H
Y
T
I
E
A
C
V
T
S
Q
F
E
Q
H
I
R
A
I
M
--
N
L
P
L
G
S
T
E
L
L
I
-
P
A
V
M
V
N
L
L
G
E
-------------
E
G
-
Y
Y
G
K
P
A
L
I
G
L
-----
E
E
---
A
--
L
A
I
E
G
L
-
S
L
H
F
Y
G
K
K
E
T
R
P
Y
R
K
M
G
H
F
T
V
V
D
R
12
PsiBlast_PDB
84.64
36%
-85
- C1 -
4MA5
5
?
A:
[3-344]
-----------
I
G
I
I
G
A
G
Q
L
A
R
M
L
S
L
A
G
T
P
L
G
L
E
F
H
C
L
G
K
-
N
G
D
C
A
E
E
V
V
K
T
V
T
D
I
E
L
T
K
V
N
D
V
V
A
W
A
K
Q
F
D
V
I
T
F
E
N
E
N
I
S
H
E
L
I
K
-
A
I
-
N
--
H
E
V
-
S
V
Y
P
S
A
K
A
I
A
I
S
Q
D
R
L
L
E
K
S
F
M
Q
D
H
G
I
A
T
A
K
F
V
N
I
D
S
L
A
K
L
Q
S
A
V
D
D
H
G
---
L
P
A
I
L
K
T
R
-
R
F
G
Y
D
G
K
G
Q
F
V
I
R
S
Q
E
D
I
T
K
A
W
D
V
LK
D
A
P
D
G
L
I
Y
E
A
F
V
D
F
D
-
Y
E
V
S
Q
I
C
T
A
D
L
K
G
N
I
A
F
Y
P
L
A
R
N
T
H
K
Q
G
I
I
V
E
S
E
A
P
F
E
---
N
V
V
L
A
E
-
K
A
Q
Q
I
A
K
I
L
V
K
E
F
A
Y
V
G
T
L
A
I
E
F
F
V
-
K
--
E
L
I
V
N
E
I
A
P
R
V
H
N
S
G
H
W
S
I
D
G
A
V
T
S
Q
F
E
N
H
V
R
A
I
A
--
G
L
I
L
G
D
T
T
S
R
K
-
T
V
M
L
N
C
I
G
G
M
-------------
P
A
-
T
-------
K
D
-----
L
A
---
A
--
L
D
--
R
V
-
K
I
H
S
Y
-
N
K
E
P
R
K
G
R
K
V
G
H
L
N
L
N
L
N
11
PsiBlast_PDB
84.30
36%
-85
- C1 -
4MA0
4
?
A:
[3-344]
-----------
I
G
I
I
G
A
G
Q
L
A
R
M
L
S
L
A
G
T
P
L
G
L
E
F
H
C
L
G
K
-
N
G
D
C
A
E
E
V
V
K
T
V
T
D
I
E
L
T
K
V
N
D
V
V
A
W
A
K
Q
F
D
V
I
T
F
E
N
E
N
I
S
H
E
L
I
K
-
A
I
-
N
--
H
E
V
-
S
V
Y
P
S
A
K
A
I
A
I
S
Q
D
R
L
L
E
K
S
F
M
Q
D
H
G
I
A
T
A
K
F
V
N
I
D
S
L
A
K
L
Q
S
A
V
D
D
H
G
---
L
P
A
I
L
K
T
R
-
R
F
G
Y
D
G
K
G
Q
F
V
I
R
S
Q
E
D
I
T
K
A
W
D
V
LK
D
A
P
D
G
L
I
Y
E
A
F
V
D
F
D
-
Y
E
V
S
Q
I
C
T
A
D
L
K
G
N
I
A
F
Y
P
L
A
R
N
T
H
K
Q
G
I
I
V
E
S
E
A
P
F
E
---
N
V
V
L
A
E
-
K
A
Q
Q
I
A
K
I
L
V
K
E
F
A
Y
V
G
T
L
A
I
E
F
F
V
-
K
G
D
E
L
I
V
N
E
I
A
P
R
V
H
N
S
G
H
W
S
I
D
G
A
V
T
S
Q
F
E
N
H
V
R
A
I
A
--
G
L
I
L
G
D
T
T
S
R
K
-
T
V
M
L
N
C
I
G
G
M
-------------
P
A
-
T
-------
K
D
-----
L
A
---
A
--
L
D
--
R
V
-
K
I
H
S
Y
-
N
K
E
P
R
K
G
R
K
V
G
H
L
N
L
N
L
N
27
PsiBlast_CBE
82.94
36%
-83
- C1 -
3AW8
3
?
B:
[12-341]
---------------------
R
M
L
A
L
A
G
Y
P
L
G
L
-
S
F
R
F
L
D
P
S
P
E
A
C
A
G
Q
V
G
E
L
V
V
G
E
F
L
D
E
G
A
L
L
R
F
A
E
G
L
A
L
V
T
Y
E
F
E
N
V
P
V
E
A
A
R
-
R
L
-
E
--
G
R
L
-
P
L
Y
P
P
A
K
A
L
E
V
A
Q
D
R
L
R
E
K
T
F
F
Q
G
L
G
V
P
T
P
P
F
H
P
V
D
G
P
E
D
L
E
E
G
L
K
R
V
G
---
L
P
A
L
L
K
T
R
-
R
G
------
Q
A
L
V
R
T
E
E
E
A
L
E
A
L
K
A
--
L
G
G
R
G
L
I
L
E
G
F
V
P
F
D
-
R
E
V
S
L
L
A
V
R
G
R
T
G
E
V
A
F
Y
P
L
V
E
N
R
H
W
G
G
I
L
R
L
S
L
A
P
A
P
-
G
-
A
S
E
A
L
Q
K
K
A
E
A
Y
A
L
R
A
M
E
A
L
D
Y
V
G
V
L
A
L
E
F
F
Q
V
-
G
E
E
L
L
F
N
E
M
A
P
R
V
H
N
S
G
H
W
T
I
E
G
A
E
T
S
Q
F
E
N
H
L
R
A
V
L
--
G
L
P
L
G
S
T
A
P
R
G
-
Q
S
A
M
V
N
L
I
G
E
-------------
K
P
---------
P
F
-----
A
E
---
V
--
L
K
V
E
G
A
-
H
L
H
W
Y
G
K
A
-
V
R
P
G
R
K
V
G
H
I
T
L
R
R
D
7
PsiBlast_PDB
82.67
36%
-85
- C1 -
3AW8
2
?
A:
[12-341]
---------------------
R
M
L
A
L
A
G
Y
P
L
G
L
-
S
F
R
F
L
D
P
S
P
E
A
C
A
G
Q
V
G
E
L
V
V
G
E
F
L
D
E
G
A
L
L
R
F
A
E
G
L
A
L
V
T
Y
E
F
E
N
V
P
V
E
A
A
R
-
R
L
-
E
--
G
R
L
-
P
L
Y
P
P
A
K
A
L
E
V
A
Q
D
R
L
R
E
K
T
F
F
Q
G
L
G
V
P
T
P
P
F
H
P
V
D
G
P
E
D
L
E
E
G
L
K
R
V
G
---
L
P
A
L
L
K
T
R
-
R
G
------
Q
A
L
V
R
T
E
E
E
A
L
E
A
L
K
A
--
L
G
G
R
G
L
I
L
E
G
F
V
P
F
D
-
R
E
V
S
L
L
A
V
R
G
R
T
G
E
V
A
F
Y
P
L
V
E
N
R
H
W
G
G
I
L
R
L
S
L
A
P
A
P
-
G
-
A
S
E
A
L
Q
K
K
A
E
A
Y
A
L
R
A
M
E
A
L
D
Y
V
G
V
L
A
L
E
F
F
Q
V
-
G
E
E
L
L
F
N
E
M
A
P
R
V
H
N
S
G
H
W
T
I
E
G
A
E
T
S
Q
F
E
N
H
L
R
A
V
L
--
G
L
P
L
G
S
T
A
P
R
G
-
Q
S
A
M
V
N
L
I
G
E
-------------
K
P
---------
P
F
-----
A
E
---
V
--
L
K
V
E
G
A
-
H
L
H
W
Y
G
K
A
-
V
R
P
G
R
K
V
G
H
I
T
L
R
R
D
30
HHSearch
82.46
34%
-76
* C1 *
3ORQ
3
?
A:
[4-360]
M
N
F
N
K
L
K
F
G
A
T
I
G
I
I
G
G
G
Q
L
G
K
M
M
A
Q
S
A
Q
K
M
G
Y
K
V
V
V
L
D
P
S
E
D
C
P
C
R
Y
V
A
H
E
F
I
Q
A
K
Y
D
D
E
K
A
L
N
Q
L
G
Q
K
C
D
V
I
T
Y
E
F
E
N
I
S
A
Q
Q
L
K
-
L
L
C
E
K
-
Y
N
I
-
P
--
Q
G
Y
Q
A
I
Q
L
L
Q
D
R
L
T
E
K
E
T
L
K
S
A
G
T
K
V
V
P
F
I
S
V
K
E
S
T
D
I
D
K
A
I
E
T
L
G
---
Y
P
F
I
V
K
T
R
-
F
G
G
Y
D
G
K
G
Q
V
L
I
N
N
E
K
D
L
Q
E
G
F
K
L
--
I
E
T
S
E
C
V
A
E
K
Y
L
N
I
K
-
K
E
V
S
L
T
V
T
R
G
N
N
N
Q
I
T
F
F
P
L
Q
E
N
E
H
R
N
Q
I
L
F
K
T
I
V
P
A
R
-
I
-
D
K
--
T
A
-
E
A
K
E
Q
V
N
K
I
I
Q
S
I
H
F
I
G
T
F
T
V
E
F
F
I
D
S
N
N
Q
L
Y
V
N
E
I
A
P
R
P
H
N
S
G
H
Y
S
I
E
A
C
D
Y
S
Q
F
D
T
H
I
L
A
V
T
--
G
Q
S
L
P
N
S
I
E
L
L
K
P
A
V
M
M
N
L
L
G
K
-------------
D
--
L
-------
D
L
-----
L
E
---
N
EF
N
E
H
P
E
W
-
H
L
H
I
Y
G
K
S
E
R
K
D
S
R
K
M
G
H
M
T
V
L
T
N
8
PsiBlast_PDB
78.73
33%
-77
- C1 -
3ORQ
3
?
A:
[21-357]
-----------------
G
Q
L
G
K
M
M
A
Q
S
A
Q
K
M
G
Y
K
V
V
V
L
D
P
S
E
D
C
P
C
R
Y
V
A
H
E
F
I
Q
A
K
Y
D
D
E
K
A
L
N
Q
L
G
Q
K
C
D
V
I
T
Y
E
F
E
N
I
S
A
Q
Q
L
K
-
L
L
-
C
--
E
K
Y
-
N
I
P
Q
G
Y
Q
A
I
Q
L
L
Q
D
R
L
T
E
K
E
T
L
K
S
A
G
T
K
V
V
P
F
I
S
V
K
E
S
T
D
I
D
K
A
I
E
T
L
G
---
Y
P
F
I
V
K
T
R
-
F
G
G
Y
D
G
K
G
Q
V
L
I
N
N
E
K
D
L
Q
E
G
F
K
L
--
I
E
T
S
E
C
V
A
E
K
Y
L
N
I
K
-
K
E
V
S
L
T
V
T
R
G
N
N
N
Q
I
T
F
F
P
L
Q
E
N
E
H
R
N
Q
I
L
F
K
T
I
V
P
A
R
-
I
-
D
K
--
T
A
-
E
A
K
E
Q
V
N
K
I
I
Q
S
I
H
F
I
G
T
F
T
V
E
F
F
I
D
S
N
N
Q
L
Y
V
N
E
I
A
P
R
P
H
N
S
G
H
Y
S
I
E
A
C
D
Y
S
Q
F
D
T
H
I
L
A
V
T
GQ
S
L
P
N
S
I
E
L
L
K
--
P
A
V
M
M
N
L
L
G
K
-------------
D
L
D
L
-------
L
E
-----
N
E
---
F
--
N
E
H
P
E
W
-
H
L
H
I
Y
G
K
S
E
R
K
D
S
R
K
M
G
H
M
T
V
L
T
N
38
HHSearch
77.08
31%
-77
- C1 -
3ETH
3
PURK_ECOLI
A:
[1-323]
--------
M
K
Q
V
C
V
L
G
N
G
Q
L
G
R
M
L
R
Q
A
G
E
P
L
G
I
A
V
W
P
V
G
L
D
A
E
P
-
A
A
V
P
-------------------
F
Q
Q
S
V
I
T
A
E
I
E
R
W
P
E
---
T
-
A
L
T
R
Q
-
L
A
R
H
P
A
F
V
N
R
D
V
F
P
I
I
A
D
R
L
T
Q
K
Q
L
F
D
K
L
H
L
P
T
A
P
W
Q
L
L
A
E
R
S
E
W
P
A
V
F
D
R
L
G
---
E
L
A
I
V
K
R
R
T
G
-
G
Y
D
G
R
G
Q
W
R
L
R
A
N
E
T
E
Q
-
L
P
A
---
E
C
Y
G
E
C
I
V
E
Q
G
I
N
F
S
-
G
E
V
S
L
V
G
A
R
G
F
D
G
S
T
V
F
Y
P
L
T
H
N
L
H
Q
D
G
I
L
R
T
S
V
A
F
P
Q
-
A
-
N
A
Q
Q
Q
A
-
R
A
E
E
M
L
S
A
I
M
Q
E
L
G
Y
V
G
V
M
A
M
E
C
F
V
T
P
Q
-
G
L
L
I
N
E
L
A
P
R
V
H
N
S
G
H
W
T
Q
N
G
A
S
I
S
Q
F
E
L
H
L
R
A
I
T
--
D
L
P
L
P
Q
P
V
V
N
N
-
P
S
V
M
I
N
L
I
G
S
-------------
D
V
---------
N
------
Y
D
---
W
--
L
K
L
P
L
V
-
H
L
H
W
Y
D
K
-
E
V
R
P
G
R
K
V
G
H
L
N
L
T
D
S
18
PsiBlast_PDB
76.59
30%
-80
- C1 -
3ETJ
5
PURK_ECOLI
A:
[6-320]
-------------
V
L
G
N
G
Q
L
G
R
M
L
R
Q
A
G
E
P
L
G
--
I
A
V
W
P
V
G
L
D
A
E
P
A
A
V
----------------
P
F
Q
Q
S
V
--
I
T
A
E
I
E
R
W
P
E
T
A
L
T
-
R
Q
-
L
--
A
R
H
-
P
A
F
V
N
R
D
V
F
P
I
I
A
D
R
L
T
Q
K
Q
L
F
D
K
L
H
L
P
T
A
P
W
Q
L
L
A
E
R
S
E
W
P
A
V
F
D
R
L
G
---
E
L
A
I
V
K
R
R
-
T
G
G
Y
D
G
R
G
Q
W
R
L
-
R
A
N
E
T
E
Q
L
P
A
---
E
C
Y
G
E
C
I
V
E
Q
G
I
N
F
S
-
G
E
V
S
L
V
G
A
R
G
F
D
G
S
T
V
F
Y
P
L
T
H
N
L
H
Q
D
G
I
L
R
T
S
V
A
F
P
Q
-
A
-
N
A
Q
Q
Q
A
-
R
A
E
E
M
L
S
A
I
M
Q
E
L
G
Y
V
G
V
M
A
M
E
C
F
V
T
P
Q
G
-
L
L
I
N
E
L
A
P
R
V
H
N
S
G
H
W
T
Q
N
G
A
S
I
S
Q
F
E
L
H
L
R
A
I
T
--
D
L
P
L
P
Q
P
V
V
N
N
-
P
S
V
M
I
N
L
I
G
S
-------------
D
V
----------
N
-----
Y
D
---
W
--
L
K
L
P
L
V
-
H
L
H
W
Y
-
D
K
E
V
R
P
G
R
K
V
G
H
L
N
L
T
D
S
17
PsiBlast_PDB
76.54
30%
-84
- C1 -
3ETH
3
PURK_ECOLI
A:
[6-320]
-------------
V
L
G
N
G
Q
L
G
R
M
L
R
Q
A
G
E
P
L
G
--
I
A
V
W
P
V
G
L
D
A
E
P
A
A
V
----------------
P
F
Q
Q
S
V
--
I
T
A
E
I
E
R
W
P
E
T
A
L
T
-
R
Q
-
L
--
A
R
H
-
P
A
F
V
N
R
D
V
F
P
I
I
A
D
R
L
T
Q
K
Q
L
F
D
K
L
H
L
P
T
A
P
W
Q
L
L
A
E
R
S
E
W
P
A
V
F
D
R
L
G
---
E
L
A
I
V
K
R
R
-
T
G
G
Y
D
G
R
G
Q
W
R
L
-
R
A
N
E
T
E
Q
L
P
A
---
E
C
Y
G
E
C
I
V
E
Q
G
I
N
F
S
-
G
E
V
S
L
V
G
A
R
G
F
D
G
S
T
V
F
Y
P
L
T
H
N
L
H
Q
D
G
I
L
R
T
S
V
A
F
P
Q
-
A
-
N
A
Q
Q
Q
A
-
R
A
E
E
M
L
S
A
I
M
Q
E
L
G
Y
V
G
V
M
A
M
E
C
F
V
T
P
Q
G
-
L
L
I
N
E
L
A
P
R
V
H
N
S
G
H
W
T
Q
N
G
A
S
I
S
Q
F
E
L
H
L
R
A
I
T
--
D
L
P
L
P
Q
P
V
V
N
N
-
P
S
V
M
I
N
L
I
G
S
-------------
D
V
----------
N
-----
Y
D
---
W
--
L
K
L
P
L
V
-
H
L
H
W
Y
-
D
K
E
V
R
P
G
R
K
V
G
H
L
N
L
T
D
S