@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0044: (2015-11-28 )
MSNKIGFLAVFALVISSQIGSGIFMLPISLAPYSTYSLISWAISGFGAVSLALVFATLCAKFPETGGPHVYVKHAFGPTAAFFVGWTYWVISWVSTTALIVVGVGYLTPFLHEEIKNIHLFLELLLFTIITLINLRGVATAGRVEFLLTVIKIAVLLAIPVMALFFFNRNNFIISKEMSSLTISQILARSTLLTLWCFVGVELATAPAGSVNNPAKTIPRAVVLGTICVAIIYFINNFAIMGLINGNDLANSRAPYVDAIKIMFSGNWHLIISIVAFVFCVGSLNAWVLSSGQVAFGLAKDRLMPQLFAKRNEHGSPFWGITTSSSGTAILLILTSNNNFAQQITSIIDFSVVSFLFVYLACSLAFLKVVIKERNYHKLLTGSIATTFCCWVILETSINTLLIASLFTTSGIPLYLFWYRRASAQ
Atome Classification :
(20 SA)
----------.........10-----------........20.....-...30-...-.---....40.-.......50....-....60........70.......---.---80.........----90.-..-..-----...100.-.....---.110-------.-..--.-..------.-.120.-...-.------...130-.-........--140.......--------150.----------......160-----........-----.170-------.---..-..---..180.--.....---..190..--...----.-----..200--.......210.......220.......230--..---.------.....240--....--.--.---------------..250........260....-----.------.-.270........280.......290--.......300-----.......310.....--..320.--......330.....--------------..340......----------------------------.350.......360..---...--..----370----...--.----..-----------.380.....------..390....-------------..---.400.--......-410.---......420...--------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------MSN
K
I
G
F
L
A
V
F
-----------
A
L
V
I
S
S
QIGS
G
I
F
M
L
-
P
I
SLA-PY
S
-
T
---
Y
S
L
I
S
W
A
-
I
SG
F
G
A
V
S
L
A
L
V
F
-
A
T
L
C
A
KFPETGG
P
H
V
Y
V
K
HAFGP---T---A-
A
F
F
V
G
W
T
Y
W
----
V
I
S
-
W
V-S
T
-----
T
A
L
I
V
V
G
-
V
G
Y
L
T
---
P
F
L
--------
H
-
E
E
--
I
-
K
N
------
I
-
H
L
F
-
L
-
E
L
L
-
L
------
F
T
I
I
---
T
-
L
I
NLRGVA--TA
G
R
V
E
F
L
L
T
--------
V
I
K
I
----------
A
V
L
L
A
I
P
-------
V
M
A
L
F
FFN-----RN
N
F
-------
I
---
I
S
-
K
E
---
M
S
S
-
L
T
--
I
S
Q
I
L
---
A
R
S
T
-
L
L
--
T
L
W
----
C
-----
F
V
G
V
E
--
L
ATAPAGSVN
N
P
A
K
T
I
P
R
A
V
V
L
G
T
I
C
V
A
I
---
I
Y
---
F
------
I
NN
F
A
I
M
---
G
L
IN--G--N---------------DLA-NSRAPY
V
D
A
I
K
I
M
FSG-----N------
W
-
H
L
-
I
I
S
I
V
A
F
V
F
C
VGSL
N
A
W
V
LSSG--
Q
V
A
F
G
L
A
K
D
R
-----
L
M
P
Q
L
F
A
KRNEHGS
P
--
F
W
G
I
T
T--SSSG
T
A
I
L
L
I
L
TSN--------------N
N
F
A
Q
Q
I
T
S
I
I
----------------------------
D
F
S
V
V
S
F
L
F
V
Y
L
A
C
S
L
---
A
F
L
--
K
V
----
V
I
K----ERN--
Y
----
H
K
-----------
L
L
T
G
S
I
A
T
T
------
F
C
C
W
V
I
L
ET-------------S
I
---
N
T
L
L
I
--
A
S
L
FTT-SG
I
P
---
L
Y
L
F
W
Y
RRASAQ--------------------------------------------------------------------------------------------------------------------
10
HHSearch
94.44
28%
-140
- C5 -
3L1L
2
ADIC_ECO57
A:
[7-432]
-----------
A
H
K
V
G
L
I
P
V
T
-----------
L
M
V
S
G
A
I
M
G
S
G
V
F
L
L
-
P
A
N
L
A
-
S
T
G
-
G
---
I
A
I
Y
G
W
L
-
V
T
I
I
G
A
L
G
L
S
M
V
Y
-
A
K
M
S
F
L
D
P
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
P
---
F
---
L
-
G
Y
Q
T
N
V
L
Y
W
----
L
A
C
-
W
I
-
G
N
-----
I
A
M
V
V
I
G
-
V
G
Y
L
S
---
Y
F
F
--------
P
-
I
L
--
K
-
D
P
------
W
-
V
L
T
I
T
-
C
V
V
-
V
------
L
W
I
F
---
V
-
L
L
N
I
V
G
P
K
--
M
I
T
R
V
Q
A
V
A
T
--------
V
L
A
L
----------
I
P
I
V
G
I
A
-------
V
F
G
W
F
W
F
R
-----
G
E
T
Y
-------
M
---
A
------------------
A
I
---
Q
S
T
L
-
N
V
--
T
L
W
----
S
-----
F
I
G
V
E
--
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
---
C
Y
---
V
------
L
S
T
T
A
I
M
---
G
M
I
P
--
N
--
A
---------------
A
L
R
-
V
S
A
S
P
F
G
D
A
A
R
M
A
L
G
D
-----
T
------
A
-
G
A
-
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
--
Q
T
A
K
A
A
A
D
D
G
-----
L
F
P
P
I
F
A
R
V
N
K
A
G
T
P
--
V
A
G
L
I
I
--
V
G
I
L
M
T
I
F
Q
L
S
S
I
S
--------------
P
N
A
T
K
E
F
G
L
V
S
----------------------------
S
V
S
V
I
F
T
L
V
P
Y
-
L
Y
T
C
---
A
A
L
--
L
L
----
L
G
H
----
G
H
F
--
G
KARP
A
Y
-----------
L
A
V
T
T
I
A
F
L
------
Y
C
I
W
A
V
V
G
S
-------------
G
A
---
K
E
V
M
W
--
S
F
V
T
L
M
-
V
I
T
A
---
M
Y
A
L
N
Y
N
R
L
H
K
N
--------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
92.62
28%
-142
- C5 -
3OB6
1
ADIC_ECOLI
A:
[7-411]
-----------
A
H
K
V
G
L
I
P
V
T
-----------
L
M
V
S
G
N
I
M
G
S
G
V
F
L
L
-
P
A
N
L
A
-
S
T
G
-
G
---
I
A
I
Y
G
W
L
-
V
T
I
I
G
A
L
G
L
S
M
V
Y
-
A
K
M
S
F
L
D
P
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
P
---
F
---
L
-
G
Y
Q
T
N
V
L
Y
W
----
L
A
C
-
W
I
-
G
A
-----
I
A
M
V
V
I
G
-
V
G
Y
L
S
YFF
P
I
L
--------
K
-
D
P
--
L
---------
V
-
L
T
I
-
T
-
C
V
V
-
V
------
L
W
I
F
---
V
-
L
L
N
I
V
G
P
K
--
M
I
T
R
V
Q
A
V
A
T
--------
V
L
A
L
----------
I
P
I
V
G
I
A
-------
V
F
G
W
F
W
F
R
-----
G
E
T
Y
-------
M
---
A
A
-
W
N
---
V
S
G
-
L
G
--
T
F
G
A
I
---
Q
S
T
L
-
N
V
--
T
L
W
----
S
-----
F
I
G
V
E
--
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
---
C
Y
---
V
------
L
S
T
T
A
I
M
---
G
M
I
P
--
N
--
A
---------------
A
L
R
-
V
S
A
S
P
F
G
D
A
A
R
M
A
L
G
D
-----
T
------
A
-
G
A
-
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
--
Q
T
A
K
A
A
A
D
D
G
-----
L
F
P
P
I
F
A
R
V
N
K
A
G
T
P
--
V
A
G
L
I
I
--
V
G
I
L
M
T
I
F
Q
L
S
S
I
S
--------------
P
------
G
L
V
S
----------------------------
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
---
A
L
L
--------
L
L
G
----
H
G
H
--
F
----
G
K
A
R
P
A
Y
------
L
A
V
T
T
I
A
F
L
------
Y
C
I
W
A
V
V
G
S
-------------
G
A
---
K
E
V
M
W
--
S
F
V
T
L
M
-
V
I
T
A
---
M
Y
A
L
N
Y
N
R
L
H
K
N
--------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
91.77
28%
-144
- C5 -
3L1L
2
ADIC_ECO57
A:
[7-411]
-----------
A
H
K
V
G
L
I
P
V
T
-----------
L
M
V
S
G
A
I
M
G
S
G
V
F
L
L
-
P
A
N
L
A
-
S
T
G
-
G
---
I
A
I
Y
G
W
L
-
V
T
I
I
G
A
L
G
L
S
M
V
Y
-
A
K
M
S
F
L
D
P
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
P
---
F
---
L
-
G
Y
Q
T
N
V
L
Y
W
----
L
A
C
-
W
I
-
G
N
-----
I
A
M
V
V
I
G
-
V
G
Y
L
S
YFF
P
I
L
--------
K
-
D
P
W
-
V
-
L
T
------
I
-
T
C
V
-
V
-
V
L
W
-
I
------
F
V
-------
L
L
N
I
V
G
P
K
--
M
I
T
R
V
Q
A
V
A
T
--------
V
L
A
L
----------
I
P
I
V
G
I
A
-------
V
F
G
W
F
W
F
R
-----
G
E
T
Y
-------
M
---
A
------------------
A
I
---
Q
S
T
L
-
N
V
--
T
L
W
----
S
-----
F
I
G
V
E
--
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
---
C
Y
---
V
------
L
S
T
T
A
I
M
---
G
M
I
P
--
N
--
A
---------------
A
L
R
-
V
S
A
S
P
F
G
D
A
A
R
M
A
L
G
D
-----
T
------
A
-
G
A
-
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
--
Q
T
A
K
A
A
A
D
D
G
-----
L
F
P
P
I
F
A
R
V
N
K
A
G
T
P
--
V
A
G
L
I
I
--
V
G
I
L
M
T
I
F
Q
L
S
S
I
S
--------------
P
N
A
T
K
E
F
G
L
V
S
----------------------------
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
---
A
L
L
--------
L
L
G
----
H
G
H
--
F
----
G
K
ARPAY------
L
A
V
T
T
I
A
F
L
------
Y
C
I
W
A
V
V
G
S
-------------
G
A
---
K
E
V
M
W
--
S
F
V
T
L
M
-
V
I
T
A
---
M
Y
A
L
N
Y
N
R
L
H
K
N
--------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
90.49
29%
-138
- C5 -
3NCY
-
ADIC_SALTY
A:
[10-411]
--------------
V
G
L
I
P
V
T
-----------
L
M
V
S
G
N
I
M
G
S
G
V
F
L
L
-
P
A
N
L
A
-
A
T
G
-
G
---
I
A
I
Y
G
W
L
-
V
T
I
I
G
A
L
A
L
S
M
V
Y
-
A
K
M
S
S
L
D
P
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
P
---
F
---
L
-
G
Y
Q
T
N
V
L
Y
W
----
L
A
C
-
W
I
-
G
N
-----
I
A
M
V
V
I
G
-
V
G
Y
L
S
---
Y
F
F
--------
P
-
I
L
--
K
-
D
P
------
L
-
V
L
T
-
L
-
T
C
V
A
V
------
L
W
I
F
---
V
-
L
L
N
I
V
G
P
K
--
M
I
T
R
V
Q
A
V
A
T
--------
V
L
A
L
----------
V
P
I
V
G
I
A
-------
V
F
G
W
F
W
F
K
-----
G
E
----------------
W
N
---
V
S
G
-
M
N
--
T
F
G
A
I
---
Q
S
T
L
-
N
V
--
T
L
W
----
S
-----
F
I
G
V
E
--
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
---
C
Y
---
V
------
L
S
T
T
A
I
M
---
G
M
I
P
--
N
--
A
---------------
A
L
R
-
V
S
A
S
P
F
G
D
A
A
R
M
A
L
G
D
-----
T
------
A
-
G
A
-
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
--
Q
T
A
K
A
A
A
D
D
G
-----
L
F
P
P
I
F
A
R
-----
T
P
--
V
A
G
L
L
I
--
V
G
V
L
M
T
I
F
Q
F
S
S
M
S
--------------
P
N
A
A
K
E
F
G
L
V
S
----------------------------
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
---
A
L
L
--
L
L
GHGH
F
G
K
----
A
R
P
--
L
----
Y
L
-----------
L
I
T
-
F
V
A
F
V
------
Y
C
I
W
A
V
I
G
S
-------------
G
A
---
K
E
V
M
W
--
S
F
V
T
L
M
-
V
I
T
A
---
L
Y
A
L
N
Y
N
R
I
H
K
N
--------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
86.78
28%
-139
- C5 -
3LRC
-
ADIC_ECO57
A:
[7-411]
-----------
A
H
K
V
G
L
I
P
V
T
-----------
L
M
V
S
G
N
I
M
G
S
G
V
F
L
L
-
P
A
N
L
A
-
S
T
G
-
G
---
I
A
I
Y
G
W
L
-
V
T
I
I
G
A
L
G
L
S
M
V
Y
-
A
K
M
S
F
L
D
P
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
P
---
F
---
L
-
G
Y
Q
T
N
V
L
Y
W
----
L
A
C
-
W
I
-
G
N
-----
I
A
M
V
V
I
G
-
V
G
Y
L
S
YFF
P
I
L
--------
K
-
D
P
--
L
---------
V
-
L
T
I
-
T
-
C
V
V
-
V
------
L
W
I
F
---
V
-
L
L
N
I
V
G
P
K
--
M
I
T
R
V
Q
A
V
A
T
--------
V
L
A
L
----------
I
P
I
V
G
I
A
-------
V
F
G
W
F
W
F
R
-----
G
E
T
Y
-------
M
---
A
A
-
W
N
---
V
S
G
-
L
G
--
T
F
G
A
I
---
Q
S
T
L
-
N
V
--
T
L
W
----
S
-----
F
I
G
V
E
--
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
---
C
Y
---
V
------
L
S
T
T
A
I
M
---
G
M
I
P
--
N
-------------------------------------------
T
------
A
-
G
A
-
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
--
Q
T
A
K
A
A
A
D
D
G
-----
L
F
P
P
I
F
A
R
V
N
K
A
G
T
P
--
V
A
G
L
I
I
--
V
G
I
L
M
T
I
F
Q
L
S
S
I
S
--------------
P
N
A
T
K
E
F
G
L
V
S
----------------------------
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
---
A
L
L
--------
L
L
G
----
H
G
H
--
F
----
G
K
AR
P
A
Y
------
L
A
V
T
T
I
A
F
L
------
Y
C
I
W
A
V
V
G
S
-------------
G
A
---
K
E
V
M
W
--
S
F
V
T
L
M
-
V
I
T
A
---
M
Y
A
L
N
Y
N
R
L
H
K
N
--------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
84.97
28%
-134
- C5 -
3LRB
-
ADIC_ECO57
A:
[7-411]
-----------
A
H
K
V
G
L
I
P
V
T
-----------
L
M
V
S
G
N
I
M
G
S
G
V
F
L
L
-
P
A
N
L
A
-
S
T
G
-
G
---
I
A
I
Y
G
W
L
-
V
T
I
I
G
A
L
G
L
S
M
V
Y
-
A
K
M
S
F
L
D
P
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
P
---
F
---
L
-
G
Y
Q
T
N
V
L
Y
W
----
L
A
C
-
W
I
-
G
N
-----
I
A
M
V
V
I
G
-
V
G
Y
L
S
YFF
P
I
L
--------
K
-
D
P
--
L
---------
V
-
L
T
I
-
T
-
C
V
V
-
V
------
L
W
I
F
---
V
-
L
L
N
I
V
G
P
K
--
M
I
T
R
V
Q
A
V
A
T
--------
V
L
A
L
----------
I
P
I
V
G
I
A
-------
V
F
G
W
F
W
F
R
-----
G
E
T
Y
-------
M
---
A
A
-
W
N
---
V
S
G
-
L
G
--
T
F
G
A
I
---
Q
S
T
L
-
N
V
--
T
L
W
----
S
-----
F
I
G
V
E
--
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
---
C
Y
---
V
------
L
S
T
T
A
I
M
---
G
M
I
P
--
N
-------------------------------------------
T
------
A
-
G
A
-
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
--
Q
T
A
K
A
A
A
D
D
G
-----
L
F
P
P
I
F
A
R
V
N
K
A
G
T
P
--
V
A
G
L
I
I
--
V
G
I
L
M
T
I
F
Q
L
S
S
I
S
--------------
P
N
A
T
K
E
F
G
L
V
S
----------------------------
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
---
A
L
L
--------
L
L
G
----
H
G
H
--
F
----
G
K
ARPAY------
L
A
V
T
T
I
A
F
L
------
Y
C
I
W
A
V
V
G
S
-------------
G
A
---
K
E
V
M
W
--
S
F
V
T
L
M
-
V
I
T
A
---
M
Y
A
L
N
Y
N
R
L
H
K
N
--------------------------------------------------------------------------------------------------------------------
20
Fugue
78.83
19%
-137
- C5 -
3GIA
7
Y609_METJA
A:
[3-435]
---------L
K
N
K
K
L
S
L
W
E
A
V
-----------
S
M
A
V
G
V
M
I
G
A
S
I
F
S
I
-
F
G
V
G
A
-
K
I
A
G
R
---
N
L
P
E
T
F
I
-
L
S
G
I
Y
A
L
L
V
A
Y
S
Y
-
T
K
L
G
A
K
I
V
S
N
A
G
P
I
A
F
I
H
K
A
I
G
D
N--
I
---
I
-
T
G
A
L
S
I
L
L
W
----
M
S
Y
-
V
I
-
S
I
-----
A
L
F
A
K
G
F
-
A
G
Y
F
L
---
P
L
I
--------
N
-
A
P
--
I
N
T
F
------
N
-
I
A
I
-
T
-
E
I
G
-
I
------
V
A
F
F
---
T
-
A
L
N
F
F
G
S
K
--
A
V
G
R
A
E
F
F
I
V
--------
L
V
K
L
----------
L
I
L
G
L
F
I
-------
F
A
G
L
I
T
I
H
-----
P
S
Y
V
------------
I
-
P
D
---
L
A
P
-
S
A
--
V
S
G
M
I
---
F
A
S
A
-
I
F
---
F
L
----
S
-----
Y
M
G
F
G
--
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
---
V
Y
---
V
------
G
V
A
I
S
A
I
---
G
N
L
P
--
I
--
D
---------------
E
L
I
K
A
S
E
N
A
L
A
V
A
A
K
P
F
L
G
N
-----
L
------
G
-
F
L
-
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
--
N
V
A
Y
S
L
A
K
D
G
-----
E
L
P
E
F
F
E
R
K
V
W
F
K
S
T
--
E
G
L
Y
I
T
--
S
A
L
G
V
L
F
A
L
L
F
N
----------------------
M
E
G
V
A
----------------------------
S
I
T
S
A
V
F
M
V
I
Y
L
F
V
I
L
---
S
H
Y
--
I
L
----
I
D
E
VGGR
K
E
I
--
V
----
I
F
-----------
S
F
I
V
V
L
G
V
F
------
L
L
L
L
Y
Y
Q
W
I
-------------
T
N
---
R
F
V
F
Y
--
G
I
I
A
T
F
-
I
G
V
L
---
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
NNMYVKS----------------------------------------------------------------------------------------------------------
11
HHSearch
76.77
19%
-138
- C5 -
3GIA
7
Y609_METJA
A:
[4-424]
----------
K
N
K
K
L
S
L
W
E
A
V
-----------
S
M
A
V
G
V
M
I
G
A
S
I
F
S
I
-
F
G
V
G
A
K
I
A
G
-
R
---
N
L
P
E
T
F
I
-
L
S
G
I
Y
A
L
L
V
A
Y
S
Y
-
T
K
L
G
A
K
I
V
S
N
A
G
P
I
A
F
I
H
K
A
I
G
D
---
N
---
I
I
T
G
A
L
S
I
L
L
W
----
M
S
Y
-
V
I
-
S
I
-----
A
L
F
A
K
G
F
-
A
G
Y
F
L
---
P
L
I
--------
N
-
A
P
--
I
-
N
T
------
F
N
I
A
I
-
T
-
E
I
G
-
I
------
V
A
F
F
---
T
-
A
L
N
F
F
G
S
K
--
A
V
G
R
A
E
F
F
I
V
--------
L
V
K
L
----------
L
I
L
G
L
F
I
-------
F
A
G
L
I
T
I
H
-----
P
S
Y
V
-------
I
---
P
D
-
L
A
---
P
----
S
--
A
V
S
G
M
---
I
F
A
S
-
A
I
--
F
F
L
----
S
-----
Y
M
G
F
G
--
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
---
V
Y
---
V
------
G
V
A
I
S
A
I
---
G
N
L
P
--
I
--
D
---------------
E
L
I
K
A
S
E
N
A
L
A
V
A
A
K
P
F
L
G
N
-----
L
------
G
-
F
L
-
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
--
N
V
A
Y
S
L
A
K
D
G
-----
E
L
P
E
F
F
E
R
K
V
W
F
K
S
T
---
E
G
L
Y
I
--
T
S
A
L
G
V
L
F
A
L
L
F
---------------------
N
M
E
G
V
A
----------------------------
S
I
T
S
A
V
F
M
V
I
Y
-
L
F
V
I
---
L
S
H
--
Y
I
----
L
I
D
----
E
V
G
GR
K
----
E
I
-----------
V
I
F
S
F
I
V
V
L
------
G
V
F
L
L
L
L
Y
Y
-------------
Q
W
I
T
N
R
F
V
F
Y
--
G
I
I
A
T
F
-
I
G
V
L
---
I
F
E
I
I
Y
R
K
V
T
K
R
--------------------------------------------------------------------------------------------------------------------
21
Fugue
70.36
15%
-146
* C5 *
4DJK
-
GADC_ECOLI
A:
[12-501]
-------------
Q
L
T
L
L
G
F
F
-----------
A
I
T
A
S
M
V
--
M
A
V
Y
E
Y
-
P
T
F
A
T
-
S
G
F
-
S
---
L
V
F
F
L
L
L
-
G
G
I
L
W
F
I
P
V
G
L
C
A
-
A
E
M
A
T
V
D
G
--
W
G
V
F
A
W
V
S
N
T
L
G
P
---
R
---
W
-
G
F
A
A
I
S
F
G
Y
----
L
Q
I
-
A
I
G
F
I
-----
P
M
L
Y
F
V
L
-
G
A
L
S
Y
---
I
L
K
--------
W
-
P
A
--
L
-
N
E
------
D
-
P
I
T
-
K
-
T
I
A
-
A
------
L
I
I
L
W
A
L
A
-
L
T
Q
F
G
G
T
K
--
Y
T
A
R
I
A
K
V
G
F
--------
F
A
G
I
----------
L
L
P
A
F
I
L
-------
I
A
L
A
A
I
Y
L
-----
H
T
F
F
-------
P
---
D
F
-
S
K
---
V
G
T
-
L
V
--
V
----------
F
-
V
A
--
F
I
L
----
S
-----
Y
M
G
V
E
--
A
S
A
T
H
V
N
E
M
S
N
P
G
R
D
Y
P
L
A
M
L
L
L
M
V
A
A
I
C
---
L
S
---
S
------
V
G
G
L
S
I
A
---
M
V
I
P
--
G
--
N
---------------
E
I
--
N
L
S
A
G
V
M
Q
T
F
T
V
L
M
S
H
-----
V
APEIEW
T
-
V
R
-
V
I
S
A
L
L
L
L
G
V
L
A
E
I
A
S
W
I
V
G
P
S
--
R
G
M
Y
V
T
A
Q
K
N
-----
L
L
P
A
A
F
A
K
M
N
K
N
G
V
P
V
T
L
V
I
S
Q
L
--
V
I
T
S
I
A
L
I
I
L
T
N
T
G
--------------
G
G
N
N
M
S
F
L
I
A
L
----------------------------
A
L
T
V
V
I
Y
L
C
A
Y
F
M
L
F
I
---
G
Y
I
--
V
L
----
V
L
K
----
H
P
D
--
L
----
K
R
T
F
N
I
P
GGK
G
V
K
L
V
V
A
I
V
G
L
L
------
T
S
I
M
A
F
I
V
S
F
LPPDNIQGDSTD
M
Y
---
V
E
L
L
V
--
V
S
F
L
V
V
-
L
A
L
P
---
F
I
L
Y
A
V
H
F
F
L
H
P
RARSP---------------------------------------------------------------------------------------------------------------
26
Fugue
62.12
17%
-120
- C4 -
4Y9J
4
?
A:
[1-592]
TITARHTQYS
H
A
K
T
G
G
F
S
Q
T
G
-----------
P
T
L
H
N
P
Y
K
D
D
P
I
L
D
R
-
T
L
R
R
L
L
P
E
S
-
E
---
Y
M
R
V
A
A
D
-
L
S
K
F
G
D
R
I
T
S
E
---
V
E
H
L
G
R
Q
A
E
L
E
Q
P
R
L
E
H
Q
D
A
W
G
K
---
R
---
V
-
D
K
L
I
V
C
N
E
W
----
H
K
L
-
K
Q
-
I
C
-----
A
E
E
G
V
I
S
-
I
G
Y
E
D
---
S
-
V
--------
D
-
P
F
--
V
-
R
R
------
I
-
H
Q
V
-
A
-
K
L
F
-
L
------
F
S
P
S
---
A
G
L
V
S
C
P
M
A
M
--
T
D
G
A
V
K
T
L
T
S
L
NLYGKH
K
L
A
T
E
----------
A
V
D
R
L
R
S
RDPS
K
A
W
T
S
G
Q
W
M
T
E
-----
K
K
G
G
-------
S
---
D
V
-
A
G
---
G
C
D
-
T
Y
--
A
V
Q
I
D
---
K
D
T
Y
-
R
L
H
G
Y
K
W
----
F
-----
S
S
A
V
D
AD
V
A
L
T
L
A
R
I
V
D
S
D
G
N
A
L
E
G
S
R
G
L
S
L
F
L
L
K
I
---
R
D
ESG
N
------
L
N
G
I
Q
M
V
---
R
L
K
N
KL
G
--
T
---------------
K
Q
L
-
P
T
A
E
L
L
L
D
G
A
I
A
E
R
I
G
-----
D
------
Q
-
G
R
-
G
V
A
G
I
S
N
M
L
N
I
T
R
I
H
N
A
V
A
S
L
G
Y
M
R
R
I
I
S
L
A
R
D
Y
S
T
K
RV
V
F
G
Q
T
Q
S
K
W
P
L
H
T
T
T
--
L
A
K
M
E
V
--
D
T
R
G
S
M
L
L
L
F
E
A
A
R
L
L
G
L
S
E
A
GKSS
D
V
E
A
M
M
L
R
L
I
T
P
V
L
----------------------------
K
L
Y
A
G
K
Q
A
V
P
M
V
S
E
G
I
---
E
C
F
GG
Q
G
----
Y
M
E
----
D
T
G
--
L
----
P
T
-----------
L
L
R
D
A
Q
V
T
P
-----------
I
W
E
G
-------------
T
T
---
N
V
L
S
L
--
D
V
L
R
V
F
-
S
G
K
E
---
N
I
L
L
A
F
G
K
R
V
E
Q
L
L
G
NTKTED
E
K
L
K
K
S
K
E
A
V
E
S
A
L
K
Q
L
Q
K
L
L
V
K
A
S
DSAIQGETRIDSV
A
R
H
I
A
F
T
I
A
R
I
Y
S
G
A
L
L
I
D
H
A
S
DSSVAN
Q
S
D
I
E
V
A
Y
R
Y
C
CEQPLIDLRWEWFA
S
E
R
V
K
A
D
R
E
I
V
F
DNFT
9
PsiBlast_PDB
61.86
20%
-118
- C5 -
4DJI
-
GADC_ECOLI
A:
[71-401]
--------------------------------------------------------------------------------------------
E
E
G
G
V
F
A
W
V
S
N
T
L
G
P
---
R
W
G
F
A
-
A
I
S
F
G
Y
L
Q
I
----
A
I
G
-
F
I
-
P
M
-----
L
Y
F
V
L
G
A
-
L
S
Y
I
L
KW-
P
A
L
--------
N
-
E
D
P
I
T
-
K
T
------
I
-
A
A
L
-
I
-
I
L
W
-
A
------
L
A
L
T
---
Q
-
F
G
G
T
K
Y
T
A
--
R
I
A
K
V
G
F
F
A
G
--------
I
L
L
P
----------
A
F
I
L
-
I
A
-------
L
A
A
I
Y
L
-------
H
S
G
-------------
A
-
I
E
---
M
D
S
-
K
T
--
F
F
P
D
F
---
S
K
V
G
-
T
L
--
V
V
F
----
V
A
F
I
L
S
Y
M
G
V
E
--
A
S
A
T
H
V
N
E
M
S
N
P
G
R
D
Y
P
L
A
M
L
L
L
M
V
A
A
I
C
---
L
S
---
S
------
V
G
G
L
S
I
A
---
M
V
I
P
--
G
--
N
---------------
E
I
--
N
L
S
A
G
V
M
Q
T
F
T
V
L
M
S
H
VAPEI
E
------
W
-
T
V
R
V
I
S
A
L
L
L
L
G
V
L
A
E
I
A
S
W
I
V
G
P
S
--
R
G
M
Y
V
T
A
Q
K
N
-----
L
L
P
A
A
F
A
K
M
N
K
N
G
V
P
--
V
T
L
V
I
S
--
Q
L
V
I
T
S
I
A
L
I
I
L
T
N
--------------
T
G
G
G
N
N
M
S
F
L
I
A
L
--------------------------
A
L
T
V
V
I
Y
L
C
A
Y
F
M
L
F
I
---
G
Y
I
--
V
L
----
V
L
K
----
H
P
D
--
L
----
K
R
-----------
T
F
N
I
P
G
G
K
G
------
V
K
L
V
V
A
I
V
G
-------------
L
L
---
T
S
I
M
A
--
F
I
V
S
F
L
-
P
P
D
N
---
I
Q
G
D
S
T
D
M
Y
V
E
L
--------------------------------------------------------------------------------------------------------------------
27
Fugue
59.37
19%
-163
- C6 -
4QNU
3
CMOB_ECOK1
A:
[1-323]
-------------
M
I
D
F
G
N
F
Y
-----------
S
L
I
A
K
N
H
L
S
H
W
L
E
T
L
-
P
A
Q
I
A
-
N
W
Q
-
R
---
E
Q
-----------
Q
H
G
L
F
K
Q
W
-
S
N
A
V
E
F
L
P
E
I
K
P
Y
R
L
D
L
L
H
S
--------------------------------------------
V
T
-
A
E
S
E
E
---
P
L
S
--------
A
-
G
Q
--
I
-
K
R
------
I
-
E
T
L
-
M
-
R
N
L
-
M
------
P
W
R
K
---
G
-
P
F
S
L
Y
G
V
N
ID
T
E
W
R
S
D
W
K
W
D
--------
R
V
L
P
----------
H
-------------------------------------------------
L
S
D
-
L
T
-----------
G
R
T
-
I
L
--
D
V
G
----
C
-----
G
S
G
Y
H
--
M
W
R
M
I
G
A
G
A
H
--------------
L
A
V
G
I
D
PT
Q
L
---
F
------
L
C
Q
F
E
A
V
---
R
K
L
L
--
G
--
N
---------------
D
Q
-----------------------
R
------
A
-
H
L
-
L
P
L
G
I
E
Q
L
P
A
L
K
A
F
D
T
-
V
F
S
M
G
---------------------
V
L
Y
H
R
R
S
P
L
E
H
--
L
W
Q
L
K
D
Q
L
V
N
E
G
E
L
V
L
E
T
L
V
I
D
--------------
G
D
E
N
T
V
L
V
P
G
D
----------------------------
R
Y
A
Q
M
R
N
--
V
Y
F
I
P
S
A
---
L
A
L
--
K
N
----
W
L
K
----
K
C
G
--
F
----
V
D
-----------
I
R
I
A
D
V
S
V
T
TTEE
Q
R
R
T
E
W
M
V
T
E
S
-------------
L
A
---
D
F
L
D
P
--
H
D
P
G
K
T
V
E
G
Y
P
A
P
K
R
A
V
L
I
A
R
K
P
-----------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
58.90
26%
-138
- C5 -
3GI8
-
Y609_METJA
C:
[44-315]
------------------------------------------------------------------
T
F
I
-
L
S
G
I
Y
A
L
L
V
A
Y
S
Y
-
T
K
L
G
A
K
I
V
S
N
A
G
P
I
A
F
I
H
K
A
I
G
D
NII
T
---
G
-
A
L
S
I
--
L
L
W
-----
M
S
-
Y
V
-
I
S
-----
I
A
L
F
A
K
G
F
A
G
Y
F
L
---
P
L
I
--------
N
-
A
P
--
I
-
N
T
------
F
-
N
I
A
-
I
T
E
I
G
-
I
------
V
A
F
F
---
T
-
A
L
N
F
F
G
S
K
--
A
V
G
R
A
E
F
F
I
------------------------
V
L
V
A
L
L
-------
I
L
G
L
F
I
F
A
GLITI
H
P
S
Y
-------
V
---
I
--
P
D
---
L
A
P
-
S
A
--
V
S
G
M
I
---
F
A
S
A
-
I
F
--
F
L
-----
S
-----
Y
M
G
F
G
--
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
---
V
Y
---
V
GVAISA
I
G
N
L
P
I
D
---
E
L
I
K
--
A
SE
N
---------------
A
L
A
-
V
A
A
K
P
F
L
--------
G
-----
N
------
L
G
F
L
-
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
--
N
V
A
Y
S
L
A
K
D
G
-----
E
L
P
E
F
F
E
R
K
V
W
F
K
S
T
--
E
G
L
Y
I
T
--
S
A
L
G
V
L
F
A
L
L
F
N
M
E
--------------
G
V
A
S
I
T
S
A
V
F
M
----------------------------
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
---
V
G
G
--
R
K
----
E
I
V
----
I
F
S
--
F
----
I
V
-----------
V
L
G
V
F
L
L
L
L
------
Y
Y
Q
W
I
T
N
R
F
-------------
V
F
---
Y
G
I
I
A
--
T
F
I
G
V
L
-
I
F
E
I
---
I
Y
R
K
V
T
K
R
T
F
S
N
--------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
57.91
26%
-134
- C5 -
3GIA
5
Y609_METJA
A:
[44-315]
------------------------------------------------------------------
T
F
I
-
L
S
G
I
Y
A
L
L
V
A
Y
S
Y
-
T
K
L
G
A
K
I
V
S
N
A
G
P
I
A
F
I
H
K
A
I
G
D
N
I
I
T
---
G
-
A
L
S
I
--
L
L
W
-----
M
S
-
Y
V
-
I
S
-----
I
A
L
F
A
K
G
F
A
G
Y
F
L
---
P
L
I
--------
N
-
A
P
--
I
-
N
T
------
F
-
N
I
A
-
I
T
E
I
G
-
I
------
V
A
F
F
---
T
-
A
L
N
F
F
G
S
K
--
A
V
G
R
A
E
F
F
I
V
--------
L
V
K
L
----------
L
I
L
-------------
G
L
F
I
F
A
G
L
I
T
I
H
P
S
Y
-------
V
---
I
--
P
D
---
L
A
P
-
S
A
--
V
S
G
M
I
---
F
A
S
A
-
I
F
--
F
L
-----
S
-----
Y
M
G
F
G
--
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
---
V
Y
---
V
G
V
A
I
S
A
I
G
N
L
P
I
D
---
E
L
I
K
--
A
SE
N
---------------
A
L
A
-
V
A
A
K
P
F
L
--------
G
-----
N
------
L
G
F
L
-
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
--
N
V
A
Y
S
L
A
K
D
G
-----
E
L
P
E
F
F
E
R
K
V
W
F
K
S
T
--
E
G
L
Y
I
T
--
S
A
L
G
V
L
F
A
L
L
F
N
M
E
--------------
G
V
A
S
I
T
S
A
V
F
M
----------------------------
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
---
V
G
G
--
R
K
----
E
I
V
----
I
F
S
--
F
----
I
V
-----------
V
L
G
V
F
L
L
L
L
------
Y
Y
Q
W
I
T
N
R
F
-------------
V
F
---
Y
G
I
I
A
--
T
F
I
G
V
L
-
I
F
E
I
---
I
Y
R
K
V
T
K
R
T
F
S
N
--------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
57.84
26%
-136
- C5 -
3GI9
-
Y609_METJA
C:
[44-315]
------------------------------------------------------------------
T
F
I
-
L
S
G
I
Y
A
L
L
V
A
Y
S
Y
-
T
K
L
G
A
K
I
V
S
N
A
G
P
I
A
F
I
H
K
A
I
G
D
N
I
I
T
---
G
-
A
L
S
I
--
L
L
W
-----
M
S
-
Y
V
-
I
S
-----
I
A
L
F
A
K
G
F
A
G
Y
F
L
---
P
L
I
----------
A
P
--
I
-
N
T
------
F
-
N
I
A
-
I
T
E
I
G
-
I
------
V
A
F
F
---
T
-
A
L
N
F
F
G
S
K
--
A
V
G
R
A
E
F
F
I
V
--------
L
V
K
L
----------
L
I
L
-------------
G
L
F
I
F
A
G
L
I
T
I
H
P
S
Y
-------
V
---
I
--
P
D
---
L
A
P
-
S
A
--
V
S
G
M
I
---
F
A
S
A
-
I
F
--
F
L
-----
S
-----
Y
M
G
F
G
--
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
---
V
Y
---
V
G
V
A
I
S
A
I
G
N
L
P
I
D
---
E
L
I
K
--
A
SE
N
---------------
A
L
A
-
V
A
A
K
P
F
L
--------
G
-----
N
------
L
G
F
L
-
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
--
N
V
A
Y
S
L
A
K
D
G
-----
E
L
P
E
F
F
E
R
K
V
W
F
K
S
T
--
E
G
L
Y
I
T
--
S
A
L
G
V
L
F
A
L
L
F
N
M
E
--------------
G
V
A
S
I
T
S
A
V
F
M
----------------------------
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
---
V
G
G
--
R
K
----
E
I
V
----
I
F
S
--
F
----
I
V
-----------
V
L
G
V
F
L
L
L
L
------
Y
Y
Q
W
I
T
N
R
F
-------------
V
F
---
Y
G
I
I
A
--
T
F
I
G
V
L
-
I
F
E
I
---
I
Y
R
K
V
T
K
R
T
F
S
N
--------------------------------------------------------------------------------------------------------------------
24
Fugue
46.54
14%
-140
- C3 -
3J16
4
RLI1_YEAST
B:
[1-608]
----------
M
S
D
K
N
S
R
I
A
I
V
S
ADKCKPKKCR
Q
E
C
K
R
S
C
P
V
V
K
T
G
K
L
-
C
I
E
V
T
-
P
T
S
-
K
---
I
A
F
I
S
E
I
L
C
I
G
C
G
I
C
V
K
K
C
P
F
D
A
I
Q
I
I
N
L
P
T
N
L
E
A
H
V
T
H
R
--
Y
S
A
---
N
---
S
-
F
K
L
H
R
L
P
T
P
R
P
G
Q
V
L
G
-
L
V
-
G
T
N
GIG
K
S
T
A
L
K
I
L
-
A
G
K
Q
K
---
P
N
L
GRFDDPPE
W
-
Q
E
--
I
-
I
K
Y
F
RGSE
L
-
Q
N
Y
-
F
-
T
K
M
-
L
E
DD
I
K
A
I
I
K
P
---
Q
-
Y
V
D
N
I
P
R
A
--
I
K
G
P
V
Q
K
V
G
E
--------
L
L
K
L
R
MEKS
P
E
D
V
K
R
Y
I
K
I
L
Q
-------
L
E
N
V
L
K
R
D
-----
I
E
K
L
-------
S
----
G
-
G
E
---
L
Q
R
-
F
A
--
I
G
M
S
C
---
V
Q
E
A
-
D
V
--
Y
M
F
D
EPS
S
-----
Y
L
D
V
K
--
Q
R
L
N
A
A
Q
I
I
R
S
L
L
A
P
T
K
Y
V
I
C
V
E
H
D
L
S
V
L
---
D
Y
---
L
------
S
D
F
V
C
I
I
Y
--
G
V
P
S
--
V
--
Y
---------------
G
V
V
-
T
L
P
A
S
V
R
E
G
I
N
I
F
L
D
G
-----------------
H
I
P
A
E
N
L
R
F
R
T
E
A
L
Q
F
R
I
A
D
A
T
--
E
D
L
Q
N
D
S
A
S
R
-----
A
F
S
Y
P
S
L
K
K
T
Q
G
D
F
V
--
L
N
V
E
E
G
--
E
F
S
D
S
E
I
L
V
M
M
G
E
N
--------------
G
T
G
K
T
T
L
I
K
L
L
A
GALKPD
E
G
Q
D
I
P
K
L
N
V
S
M
K
P
Q
K
I
A
P
KF
P
G
T
V
R
Q
L
F
F
K
K
I
R
G
Q
F
LN
P
Q
F
Q
--
T
D
----
V
V
K
----
P
L
R
--
I
----
D
D
-----------
I
I
D
Q
E
V
-
Q
H
------
L
S
G
G
E
L
Q
R
V
-------------
A
I
---
V
L
A
L
G
IP
A
D
I
Y
L
I
-
D
E
P
S
---
A
Y
L
D
S
E
Q
R
I
I
C
S
K
V
I
R
R
F
I
L
H
N
K
K
T
A
F
I
V
E
HD
F
I
M
A
T
Y
L
AD
K
V
I
V
F
E
G
I
PS
K
N
A
H
A
R
A
P
ES
L
L
T
G
C
N
R
F
L
K
N
L
NVTFRRDPNSF
R
P
R
I
N
K
L
DS
Q
M
D
K
E
Q
K
S
S
GNYFFLDNTGI---------------
23
Fugue
38.90
11%
-98
* C6 *
3THR
3
GNMT_RAT
A:
[4-293]
------------------------------------------------------------------------------
V
D
S
V
Y
-
R
T
R
S
L
G
V
A
A
E
G
I
P
D
Q
Y
A
D
G
E
A
A
R
---
V
---
W
-
Q
L
Y
I
--------------------------------------------------
G
-
D
T
--
R
-
S
R
------
T
-
A
E
Y
-
K
-
A
W
L
-
L
------
G
L
L
R
---
Q
-
H
G
C
H
R
V
L
D
--
V
A
C
G
T
G
--------------
V
D
----------
S
I
M
L
V
E
E
-------
G
F
S
V
T
S
V
D
--------------------
A
S
-
D
K
---
M
L
K
-
Y
A
--
L
K
E
R
W
---
N
R
R
K
-
E
P
--
A
F
D
----
K
-----
W
V
I
E
E
--
A
----------
N
W
L
T
L
D
K
D
V
P
A
G
D
G
F
D
A
V
---
I
C
---
L
------
G
N
S
F
A
H
L
---
P
D
S
K
--
G
--
D
---------------
Q
----------
S
E
H
R
L
A
L
K
N
-----
I
------
A
-
S
M
-
V
R
P
G
G
L
L
V
I
D
H
R
N
Y
D
Y
-
I
L
S
T
G
--
C
A
P
P
G
-------------
K
N
I
Y
Y
K
S
D
L
T
K
D
--
I
T
T
S
V
L
--
T
V
N
N
----------------------------
K
A
H
M
V
T
L
----------------------------
D
Y
T
V
Q
V
P
A
P
G
F
S
K
F
R
L
---
S
Y
Y
--
P
H
----
C
L
A
----
S
F
T
--
E
----
L
V
-----------
Q
E
A
F
G
G
R
C
Q
------
H
S
V
L
G
D
F
K
P
-------------
Y
R
---
P
G
---------
Q
A
-
Y
V
P
C
---
Y
F
I
H
V
L
K
K
T
G
----------------------------------------------------------------------------------------------------------------------
12
HHSearch
37.79
12%
-108
- C5 -
3DH4
3
?
A:
[53-349]
-----------
G
K
S
L
P
W
W
A
V
G
-----------
A
S
L
I
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
-
S
I
G
-
L
---
A
I
A
S
Y
E
W
-
M
S
A
I
T
L
I
I
V
G
K
Y
F
-
L
P
I
F
I
E
K
-
G
I
Y
T
I
P
E
F
V
E
K
R
F
N
K
---
K
---
L
-
K
T
I
L
A
V
F
W
I
----
S
L
Y
I
F
V
-
N
L
-----
T
S
V
L
Y
L
G
-
G
L
A
L
E
---
T
I
L
--------
G
-----
I
--
P
------
L
-
M
Y
S
-
I
-
L
G
L
-
A
------
L
F
A
L
---
V
-
Y
S
I
--------
V
V
W
T
D
V
I
Q
V
--------
F
F
L
V
----------
L
G
G
F
M
T
T
-------
Y
M
A
V
S
F
I
G
G----
T
D
G
W
F
A
G
V
S
K
M
V
D
A
A
P
G
H
F
E
MIL
D
Q
S
N
P
Q
YM
N
L
P
G
I
AVL
I
G
G
L
W
V
A
--
N
L
Y
----
Y
-----
W
G
F
N
Q
--
Y
I
I
Q
R
T
L
A
A
K
S
V
S
-
E
A
Q
K
G
I
V
F
A
A
F
L
K
L
I
---
V
P
---
F
------
L
V
V
L
P
G
I
A
A
Y
V
I
T
S
--
D
--
P
Q
L
M
A
S
L
GDIAATNLP
S
A
A
-
N
A
D
K
A
Y
P
W
L
T
-
Q
F
L
P
V
-----
G
------
V
-
K
G
-
V
V
F
A
A
L
A
A
A
I
V
S
S
L
A
S
M
L
N
S
T
A
--
T
I
F
T
M
D
I
Y
K
E
-----
Y
I
S
P
D
S
G
D
H
K
L
V
N
V
G
--
R
T
A
A
V
V
--
A
L
I
I
A
C
L
I
A
P
M
L
G
G
--------------
I
G
Q
A
F
Q
Y
I
Q
E
Y
----------------------------
T
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
---
F
W
K
--
K
T
----
T
S
K
----
G
A
I
--
I
----
G
V
-----------
V
A
S
I
P
F
A
L
F
------
L
K
F
M
P
L
S
M
P
-------------
F
M
---
D
Q
M
L
Y
--
T
L
L
F
T
M
-
V
V
I
A
---
F
T
S
L
S
T
S
I
N
D
D
D
--------------------------------------------------------------------------------------------------------------------
14
HHSearch
32.46
14%
-127
- C5 -
2JLN
2
?
A:
[24-187]
-----------
E
R
S
V
G
P
F
S
L
A
-----------
A
I
W
F
A
M
A
I
Q
V
A
I
F
I
A
-
A
G
Q
M
T
--
S
S
-
F
Q
V
W
Q
V
I
V
A
I
A
-
A
G
C
T
I
A
V
I
L
L
F
F
T
-
Q
S
A
A
I
R
W
G
-
I
-
N
F
T
V
A
A
R
M
P
F
G
I
---
R
---
G
-
S
L
I
P
I
T
L
K
A
----
L
L
S
-
L
F
-
W
F
-----
G
F
Q
T
W
L
G
-
A
L
A
L
D
---
E
I
T
--------
R
L
L
T
--
G
F
T
N
------
L
-
P
L
W
-
I
--
V
I
-
F
------
G
A
I
Q
---
V
-
V
T
T
F
Y
G
I
T
--
F
I
R
W
M
N
V
F
A
S
--------
P
V
L
L
----------
A
M
G
V
Y
M
V
-------
Y
L
M
L
D
G
A
D
-----
V
S
L
G
-------
E
---
V
M
-
S
M
---
G
G
E
-
N
P
--
G
M
P
F
S
---
T
A
I
M
-
I
F
--
V
G
G
----
W
-----
I
A
V
V
V
--
S
I
H
D
I
V
K
E
C
K
V
D
P
N
A
S
R
E
G
Q
T
K
A
D
A
R
Y
A
T
---
A
Q
---
W
------
L
G
M
V
P
A
S
---
I
I
F
G
--
F
--
I
---------------
G
A
A
-
S
M
V
L
V
G
E
W
N
P
V
I
A
I
T
E
-----
V
------
V
-
G
G
-
V
S
I
P
M
A
I
L
F
Q
V
F
V
L
L
A
T
W
S
T
N
P
--
A
A
N
L
L
S
P
A
Y
T
-----
L
C
S
T
F
P
R
V
F
T
F
K
T
G
V
--
I
V
S
A
V
V
--
G
L
L
M
M
P
W
Q
F
A
G
V
L
N
--------------
T
F
L
N
L
L
A
S
A
L
G
----------------------------
P
L
A
G
I
M
I
S
D
Y
F
L
V
R
R
R
---
R
I
S
--
L
H
----
D
L
Y
----
R
T
K
--
G
----
I
Y
-----------
T
Y
W
R
G
V
N
W
V
------
A
L
A
V
Y
A
V
A
L
-------------
A
V
---
S
F
L
T
P
--
D
L
M
F
V
T
-
G
L
I
A
---
A
L
L
L
H
I
P
A
M
R
W
V
--------------------------------------------------------------------------------------------------------------------
22
Fugue
31.96
16%
249
- C5 -
1IQ5
-
?
B:
[4-27]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
R
L
D
T
L
-----
I
L
V
K
A
M
G
H
R
K
R
F
G
N
P
--
F
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------