@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0050: (2015-11-28 )
MVIVLKLPEVTVNWSYPVLNFDLSFRIILISFLSVAFLIVLPAKNFSFSEMLSFFAYTISSLCAILSKQIISVIIFCELMAISASFIIAAGCKDNGPAIRYACVHFFVGIILTAGLAIQNPNLIIMGLLIICACFPFSFWVVDAYPAASLHGASYLSLFTTKISFLIALLHTYNLWQDHAEILAFLGTITAIYGIIFTSLEQNIRRFLAYNVVGQMGILIMTGSLLSHSKNAIPLLILNIIFSIVYQLLLTAVANSIILRTKAVNFNRVGKFMSAEGIYALIAILTMAAFPGTAGFISKSYIAVEIKMNGTNLELYKNLHKILNLSLYLSVGLKFLYYIFITKSRSKLLAEKGGGVAMIILASICVIAGNPYLPIYNKPSIFNLAYNTKNIWSQLNLLLCVTLLFIPLRKLFLPRINLKMDIDWIFRALIPYVVSLFNKLIFKMRKISAGALQNLTNSLTNLYFNNANKLKEALSYDSVSFISASSLFLMSILLVLLCLNH
Atome Classification :
(20 SA)
---------------------------------------------------------------........---.10--......-.--.20........30.......-.40......------..50-......-----..60....-....70........80.......---------.90-...------..-....100...---....110...---------....----120---------------------------..--------------.......130.----......140....----.-----...150......---..160...--.----..-.170..---...-..-----180.......190.......200--.........210.......220-----........230.......240----------........250.......260-.-.----...-....270-.........280--..--.....290---.-.-.......300-.......310.......320........330.....---..340.....--.----.350-..---..----....360...-----....370-...-.....-.380--...-....-.390.--......400.......410------------.------------.---..-....420.......430....--..-----.440-----.......450....------.----..460.......470......-.480-------.......490.......500------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------
M
V
I
V
L
KLP---
E
V
T
--
V
NWSY
P
-
V
--LNFDL
S
F
R
I
I
L
I
S
F
L
S
V
A
F
L
-
I
V
LPAKNF
S
------
F
S
E
M
-
L
S
F
F
A
Y
-----
T
I
S
S
L
C
A
I
-
L
S
K
Q
I
I
S
V
I
I
F
C
E
L
M
A
IS
A
S
F
I
I
---------
A
A--GCK------DN-GP
A
I
R
Y
A
C
V
H
---
F
F
V
G
I
I
L
TAG---------LAIQ----N-----------------------------P
N
--------------
L
I
I
M
G
L
L
I
I
C
A
----CFP
F
S
F
W
V
-VDAY----P-----AASL-HG
A
S
Y
L
S
---
L
F
T
T
K
I
S
F
--
L
----
I
A
-
L
L
H
T
Y
N
---
L
W
Q
-
D
H
-----
A
E
I
L
A
F
L
G
T
I
T
A
I
Y
G
I
I
F
T
S
L
----
E
Q
N
I
R
R
F
L
A
Y
N
V
V
GQM
G
I
L
I
M
------T
G
S
L
LSHSKNA
I
P
L
L
I
L
N
I
I
-----------
F
S
I
V
Y
Q
L
L
L
T
A
V
AN
S
I
I
L
R
---
T
-K----AV
N
-
F
N
R
V
G
---
K
F
MSA
E
G
I
Y
A
L
I
--
A
I
--
L
T
M
AAF-----P-G-TAGFISK
S
Y
I
-
A
V
E
I
K
MNGT
N
L
E
L
Y
K
N
L
H
K
-
I
L
N
L
S
L
Y
L
S
V
G
L
K
F
L
Y
---
Y
I
F
I
TKS
R
S
K
--
L
----
L
A
E--KG---G
G
----
V
A
M
I
I
L
A
S
I
C
-----
V
IAGN---P
Y
L
-PIYNK-P
S
I
---
F
N
L
-
A
YN
T
-
K
N
I
W
S
--
Q
L
N
L
L
L
C
V
T
L
L
F
I
P
L
R
K
-
L
------------F------------L---PR-I
N
L
K
M
D
I
D
W
I
F
R
A
L
I
P
Y
V
V
S
L
--
F
N
-----
K
L
I
F
-----
K
M
R
KIS
A
G
A
L
Q
N
L
T
------
N
----
S
L
T
N
LYFN
N
A
N
K
L
K
E
A
LSYDS-V
S
F
I
-------
S
A
S
S
L
F
L
M
S
I
L
L
V
L
L
CLNH-------
5
HHSearch
87.00
15%
-153
- C4 -
3RKO
4
?
L:
[74-596]
--------------------------------------------------------------------------------
N
I
G
F
N
----
L
V
L
D
G
L
S
L
T
M
L
S
V
V
T
G
V
G
F
L
I
H
M
Y
A
S
W
Y
M
R
GEEGY-
S
R
F
F
-
A
Y
T
N
L
F
-----
I
A
S
M
V
V
L
V
-
L
A
D
N
L
L
L
M
Y
L
G
W
E
G
V
G
L
C
S
Y
L
L
I
---------
G
F
--
Y
Y
T
DP----
K
N
G
A
A
A
M
K
A
F
V
V
T
---
R
V
G
D
V
F
L
A
F
A
---------
L
F
I
L
----
Y
NELGTLNFREMVELAPAHFADGNNMLMWA
T
L
--------------
M
L
L
G
G
A
V
G
K
S
A
----
Q
L
P
L
Q
T
W
L
-
A
D
A
M
----
A
-----
G
P
T
P
-
V
S
A
L
I
H
A
---
A
T
M
V
T
A
G
V
--
Y
----
L
I
-
A
R
T
H
G
L
---
F
L
M
T
P
E
V----
L
H
L
V
G
I
V
G
A
V
T
L
L
L
A
G
F
A
A
L
V
----
Q
T
D
I
K
R
V
L
A
Y
S
T
M
S
Q
I
G
Y
M
F
L
------
A
L
G
V
Q
A
-----
W
D
A
A
I
F
H
L
M
-----------
T
H
A
F
F
K
A
L
L
F
L
A
S
G
S
V
I
L
A
---
C
H
H
----
E
Q
N
-
I
F
K
M
G
GLR
K
S
I
P
L
V
Y
L
C
F
L
V
--
G
G
--
A
A
L
S
A
L
-----
P
-
L
V
T
A
G
F
F
S
K
D
E
I
-
L
A
G
A
M
A
N
G
H
I
N
L
M
V
--
A
G
L
-
V
G
A
F
M
T
-
S
L
Y
T
F
R
M
I
F
---
I
V
F
H
G
K
E
Q
I
H
A-
H
A---
V
K
G
--
V
T
---
H
S
----
L
P
L
I
V
L
L
I
L
S
-----
T
F
V
G
A
---
L
I
V
P
P
L
Q
G
V
L
P
Q
T
TE-
L
A
H
G
S
M
L
T
-
L
E
I
T
S
--
G
V
V
A
V
V
G
I
L
L
A
A
W
L
W
L
G
-
K
------------
R
TLVTSIANSAPG
R
LLS
T
W
-
W
Y
N
A
W
G
F
D
W
L
Y
D
K
V
F
V
K
P
F
L
G
--
I
A
-----
W
--------
L
L
K
R
D
P
L
N
S
M
M
N
I
P
------
A
----
V
L
S
R
F
A
G
K
---
G
L
L
L
S
E
N
G
Y
L
-
R
W
Y
V
-------
A
S
M
S
I
G
A
V
V
V
L
A
L
L
M
V
L
---------
7
HHSearch
83.01
16%
-152
- C4 -
3RKO
4
?
N:
[67-476]
-----------------------------------------------------------------------------------------
M
R
V
D
G
F
A
M
L
Y
T
G
L
V
L
L
A
S
L
A
T
C
T
F
A
Y
P
W
L
E
GYNDNK
D
E
F
Y
-
L
L
V
L
I
A
-----
A
L
G
G
I
L
L
A
-
N
A
N
H
L
A
S
L
F
L
G
I
E
L
I
S
L
P
L
F
G
L
V
---------
G
Y
--
A
F
R
QK----
R
S
L
E
A
S
I
K
Y
T
I
L
S
---
A
A
A
S
S
F
L
L
F
G
---------
M
A
L
V
----
Y
AQSGDLSFVALGKNEPLLLAG--------
F
G
--------------
L
M
I
V
G
L
G
F
K
L
S
----
L
V
P
F
H
L
W
T
-
P
D
V
Y
----
Q
-----
G
A
P
A
-
P
V
S
T
F
L
A
---
T
-
A
S
K
I
A
I
--
F
----
G
V
V
M
R
L
F
L
Y
---
A
P
V
-
G
D
SEAI-
R
V
V
L
A
I
I
A
F
A
S
I
I
F
G
N
L
M
A
L
S
----
Q
T
N
I
K
R
L
L
G
Y
S
S
I
S
H
L
G
Y
L
L
V
------
A
L
I
A
L
Q
T
G
E
M
S
M
E
A
V
G
V
Y
L
A
-----------
G
Y
L
F
S
S
L
G
A
F
G
V
V
S
L
M
S
S
P
YRG
P
-
D
----
A
D
S
-
L
F
S
Y
R
GLF
W
H
R
P
I
L
A
A
V
M
T
V
--
M
M
--
L
S
L
A
G
I
-----
P
-
M
-
T
L
G
F
I
G
K
F
Y
V
-
L
A
V
G
V
Q
A
H
L
W
W
L
V
G
--
A
V
V
-
V
G
S
A
I
G
-
L
Y
Y
Y
L
R
V
A
V
---
S
L
Y
L
H
A
P
E
Q
P
----------SN
W
Q
YSA
G
G
----
I
V
V
L
I
S
A
L
L
V
-----
L
V
L
G
V
---
W
P
Q
-
P
L
I
S
I
-
V
R
L
---
A
M
P
-
L
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
Fugue
80.70
15%
-158
- C4 -
3RKO
4
?
B:
[1-612]
MNMLALT
I
I
L
P
L
I
G
F
V
L
L
A
F
S
RGRWS
E
N
V
S
A
I
V
G
V
G
S
V
G
L
A
A
L
V
T
A
F
I
G
V
D
F
F
A
N
GE
Q
T
Y
S
Q
P
L
W
T
W
M
S
V
G
---
D
F
N
--
I
G
F
N
L
V
-
L
D
G
L
S
L
T
M
L
S
V
V
T
G
V
G
F
L
I
H
M
Y
A
-
S
W
Y
M
R
G
E
E
G
------
Y
S
R
F
-
F
A
Y
T
N
L
-----
F
I
A
S
M
V
V
L
V
L
A
D
N
L
L
L
M
Y
L
G
W
E
G
V
G
L
C
S
Y
L
L
I
G
FYYTD
P
K
N
G
A
--
A
A
M
------
K
A
-
F
V
V
T
R
V
G
D
V
F
---
L
A
F
A
L
F
I
L
Y
N
E
LGTLN
F
R
E
M
V
E
L
----
A
-----------------------------
P
A
HFADGNN
M
L
M
W
A
T
L
M
L
L
G
G
A
V
G
K
S
A
----
Q
L
P
L
Q
T
W
L
-
A
D
A
M
----
A
GP
T
P
V
S
A
L
I
-
H
A
A
T
------
M
V
T
A
G
V
Y
L
--
I
----
A
R
-
T
H
G
L
F
L
---
M
T
P
-
E
V
-----
L
H
L
V
G
I
V
G
A
V
T
L
L
L
A
G
F
A
A
L
V
----
Q
T
D
I
K
R
V
L
A
Y
S
T
M
S
Q
I
G
Y
M
F
L
------
A
L
G
V
-----
Q
A
W
D
A
A
I
F
H
L
M
-----------
T
H
A
F
F
K
A
L
L
F
L
A
S
G
S
V
I
L
A
---
C
-
H
HEQN
I
F
K
-
M
G
G
L
R
---
K
S
I
P
L
V
Y
L
C
F
L
V
--
G
G
--
A
A
L
S
A
L
-----
P
L
V
-
T
A
G
F
F
S
K
D
E
I
-
L
A
G
A
M
A
N
G
H
I
N
L
M
V
A
G
L
V
G
-
A
F
M
T
S
L
Y
---
T
F
R
M
I
F
---
I
V
F
H
G
K
E
Q
I
H
--
A
----
H
A
V
--
K
G
---
V
T
H
S
--
L
P
L
I
V
L
L
I
L
S
-----
T
F
V
G
A
LIV
P
P
L
-
Q
G
V
L
P
-
Q
T
T
---
E
L
A
-
H
G
S
M
-
L
T
L
E
I
--
T
S
G
V
V
A
V
V
G
I
L
L
A
A
W
L
W
-
L
------------
G
------------
K
---
R
T
-
L
V
T
S
I
A
N
S
A
P
G
R
L
L
S
T
W
W
Y
N
A
WG
F
D
-----
W
L
Y
D
-----
K
V
F
V
K
P
F
L
G
I
A
W
L
L
------
K
----
R
D
P
L
N
S
M
M
N
I
P
A
V
L
S
R
F
A
G
K
G
-
L
L
L
S
-------
E
N
G
Y
L
R
W
Y
V
A
S
M
S
I
G
A
V
V
V
L
A
L
L
M
V
L
6
HHSearch
77.44
17%
-154
- C4 -
3RKO
5
?
M:
[81-487]
-----------------------------------------------------------------------------------------
L
A
I
D
G
L
S
L
L
M
V
V
L
T
G
L
L
G
V
L
A
V
L
C
S
W
K
E
I
E
KYQ---
G
F
F
H
-
L
N
L
M
W
I
-----
L
G
G
V
I
G
V
F
-
L
A
I
D
M
F
L
F
F
F
F
W
E
M
M
L
V
P
M
Y
F
L
I
---------
A
L
--
W
G
H
KASDGK
T
R
I
T
A
A
T
K
F
F
I
Y
T
---
Q
A
S
G
L
V
M
L
I
A
---------
I
L
A
L
VFVH
Y
NATGVWTFNYEELLNTPMSSGVEYLL---
M
L
--------------
G
F
F
I
A
F
A
V
K
M
P
----
V
V
P
L
H
G
W
L
-
P
D
A
H
----
S
-----
Q
A
P
T
-
A
G
S
V
D
L
A
---
G
I
L
L
K
T
A
A
--
Y
----
G
L
-
L
R
F
S
L
P
----
L
F
-
P
N
ASAEF
A
P
I
A
M
W
L
G
V
I
G
I
F
Y
G
A
W
M
A
F
A
----
Q
T
D
I
K
R
L
I
A
Y
T
S
V
S
H
M
G
F
V
L
I
------
A
I
Y
T
G
S
--
Q
L
A
Y
Q
G
A
V
I
Q
M
I
-----------
A
H
G
L
S
A
A
G
L
F
I
L
C
G
Q
L
Y
E
R
---
I
-
H
----
T
R
D
-
M
R
M
M
G
GLW
S
K
M
K
W
L
P
A
L
S
L
F
--
F
A
--
V
A
T
L
G
M
-----
P
-
G
-
T
G
N
F
V
G
E
F
M
I
-
L
F
G
S
F
Q
V
V
P
V
-
I
T
V
--
I
S
T
-
F
G
L
V
F
A
-
S
V
Y
S
L
A
M
L
H
---
R
A
Y
F
G
K
A
K
S
Q
IA
S
QELP
G
M
S
--
L
R
---
E
L
----
F
M
I
L
L
L
V
V
L
L
-----
V
L
L
G
F
---
Y
P
Q
-
P
I
L
D
T
-
S
H
S
---
A
I
G
-
N
I
Q
Q
-
W
F
V
N
S
--
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
Fugue
75.89
19%
-138
- C1 -
4R4X
2
?
A:
[1-546]
-------------------------------------------------------------------
A
Q
T
Y
---
E
I
T
--
Y
Q
N
S
F
E
G
K
--
I
N
Q
N
---
H
I
I
S
I
T
N
S
D
K
T
L
L
-
F
N
E
K
I
K
N
K
K
------
A
D
F
P
-
F
E
V
N
E
I
NRKNN
E
V
S
Q
F
A
F
L
-
N
N
N
E
I
V
K
T
S
D
N
T
I
L
A
K
Q
E
F
K
P
T
S
---------
E
T
--
G
-
K
------
I
L
-
G
Y
N
V
K
K
A
V
T
S
V
NS
N
T
I
E
V
W
Y
T
N
D
---------
L
K
V
K
----
G
G----------------------------
P
S
--------------
I
L
G
Q
D
L
G
L
V
L
K
----
T
V
R
N
G
S
S
V
-
V
E
A
T
----
S
-----
V
K
K
I
-
K
A
L
D
D
Q
S
---
L
F
N
G
K
N
I
T
--
E
----
K
D
-
A
L
T
Y
K
D
M
--
I
W
K
-
S
R
-----
F
I
T
I
P
V
F
E
N
E
T
I
N
F
S
D
A
S
K
S
-----
D
Q
V
I
Q
R
F
------
G
N
G
T
I
I
L
K
------
K
V
K
I
P
E
I
K
Q
G
N
T
I
F
V
E
L
K
Q
K
S
NGDAYD
R
T
G
D
V
F
I
I
P
Q
E
R
A
I
S
Y
Y
T
G
L
T
Q
G
---
V
-
K
----
S
L
P
-
V
Y
Q
N
G
---
N
G
K
S
Y
Q
G
V
A
L
T
P
--
D
Y
--
L
P
F
I
E
L
M
R
F
F
T
P
-
F
-
G
I
G
H
F
N
E
K
------
I
Q
L
K
G
K
N
W
H
N
N
T
P
Y
R
Q
D
I
T
E
L
R
P
Q
L
S
-
G
K
E
I
L
I
---
G
A
F
I
G
N
Y
---------------
D
K
---
G
G
----
H
Q
I
S
L
E
L
S
I
H
PDQQK
I
V
N
N
N
---
F
V
L
-
P
V
F
N
T
-
T
N
V
MEM
A
G
Q
-
D
Y
P
T
M
F
N
S
D
K
G
V
E
V
D
F
I
L
T
K
D
L
K
N
A
Q
L
R
Y
-
I
T
T
G
H
G
GWGAGDE
F
------------
V
---
P
K
-
E
N
S
I
Y
L
D
G
K
L
A
H
A
F
T
P
W
R
T
D
C
--
G
S
-----
Y
R
L
F
NPASG
N
F
E
D
G
L
S
S
S
D
L
S
R
S
------
N
WCPG
T
I
T
N
P
V
Y
I
N
L
G
N
L
N
A
G
K
H
T
I
Q
-
V
K
I
P
Q
G
A
P
E
GS
S
Q
S
F
W
N
V
S
G
V
L
L
G
Q
E
H
H
H
H
H
H
HH---
21
Fugue
70.89
19%
-110
- C6 -
3WL8
2
OPH_PSESP
A:
[23-358]
-----------------------------------------------------------------
V
K
W
E
C
P
AG
Y
E
V
K
E
G
L
N
V
D
F
P
-
H
--
K
G
M
K
R
A
F
I
V
Y
P
A
K
N
V
S
G
P
A
P
-
V
W
V
P
M
T
G
-
S
------
V
E
S
T
-
N
D
N
L
T
V
-----
A
R
S
G
A
N
S
I
-
L
A
D
H
G
Y
T
V
I
A
P
V
R
A
C
A
N
Q
D
P
N
I
R
---------
G
E
--
R
C
N
------
G
P
-
G
S
N
---------------------------------------------------------------------------------------
G
-----------
W
N
W
N
P
W
F
---
E
G
----
R
-----
A
A
D
P
-
S
G
E
H
W
K
N
---
D
E
G
P
D
S
S
F
--
F
----
V
A
-
M
V
Q
C
V
G
---
T
K
Y
-
K
L
-----
D
A
R
R
L
F
L
G
G
I
A
--------
S
G
----
G
T
M
T
N
R
A
L
L
F
R
S
N
F
W
A
G
G
L
P
I
------
S
G
E
W
Y
V
T
S
D
D
G
T
P
L
S
------------------------
F
D
D
A
R
A
A
V
A
A
A
---
P
-
T
----
K
I
H
-
Q
G
R
V
G
---
P
Y
P
L
P
A
K
V
G
P
L
I
--
V
M
--
T
V
W
------------------------------
G
G
E
K
D
L
W
N
C
T
R
P
---
D
G
S
R
F
L
C
A
D
--------
Y
R
P
S
T
Q
A
G
S
N
--
F
----
F
S
A
--
Q
-------------------------------------------
P
D
V
---
V
H
V
-
A
C
S
S
-
T
H
---------------------
G
-
H
------------
M
------------
W
---
P
Q
-
L
N
T
Q
E
F
N
R
W
A
L
D
T
L
A
S
H
P
K
G
---
S
D
-----
P
R
S
F
-----
K
L
T
Q
P
P
E
G
-
Y
T
C
H
V
------
G
----
P
F
T
G
L
Y
A
S
A
W
S
------------------------------------------------
20
Fugue
66.93
18%
-125
* C6 *
4RU0
4
?
A:
[30-444]
---------------------------------------------------------------------------
G
P
--
D
Q
Q
F
F
P
-
L
--
A
T
Y
R
V
G
------
A
Y
A
S
S
G
V
Q
-
V
W
A
G
---------------
M
I
D
Y
L
N
Y
-----
I
N
Q
V
E
G
G
I
-
N
G
V
K
L
V
W
Q
E
C
E
T
E
W
T
A
E
K
G
I
E
C
Y
---------
E
R
F
K
N
G
L
------
D
G
-
A
P
V
A
V
Y
Q
P
N
G
---
A
P
A
A
Y
A
L
S
E
R
---------
A
E
V
D
----
K
-----------------------------
I
P
--------------
L
I
T
L
G
Y
G
R
T
E
A
TDGT
V
F
P
Y
N
F
P
V
M
L
T
F
Y
----
S
-----
E
A
S
T
-
L
-
V
N
Y
I
A
---
Q
R
E
G
G
F
D
R
--
L
KG
K
K
I
A
-
T
L
Y
H
D
S
---
A
Y
G
-
R
-------
E
T
L
G
P
L
K
L
L
A
E
K
Y
G
--
F
E
N
I
----
Q
I
P
V
A
D
---------------------
P
G
N
E
Q
S
A
Q
W
R
Q
I
R
Q
Q
N
P
D
W
V
-----------
F
L
R
T
W
G
-----
V
S
T
P
V
A
V
K
---
T
-
A
----
A
R
F
---------
G
F
P
V
D
H
I
I
G
D
I
W
--
A
S
--
S
S
E
D
V
L
-----
P
-
A
---
G
A
A
A
K
G
Y
L
-
A
L
T
P
Y
P
A
G
S
D
F
E
I
H
K
R
L
K
Q
-
Y
I
--------------------
L
D
T
G
K
S
D
--
L
----
K
D
L
--
K
N
---
F
G
S
V
Y
Y
N
S
G
L
V
N
A
A
V
A
-----
V
E
A
I
R
---
T
A
Q
-
G
K
F
G
K
-
R
P
L
---------
N
G
-
E
E
G
R
W
--
G
L
E
H
L
---
N
I
D
D
A
R
L
K
D
M
G
------------
Y
------------
L
---
G
L
M
Q
N
L
K
L
S
---------------------------------
C
R
D
H
E
G
G
G
A
A
R
V
Q
Q
W
DGA
N
W
T
----
L
I
S
E
W
I
A
A
D
R
A
L
L
R
P
L
I
D
E
K
A
-
A
A
F
A
-------
K
E
K
R
L
V
P
R
T
------
C
N
---------
19
Fugue
63.01
14%
-130
- C2 -
4D7E
1
?
A:
[1-413]
---------------------------------------------------------------------------------------------------------
M
E
T
L
-
L
V
V
G
A
G
------------
P
-
K
A
L
A
V
A
-----
A
K
S
H
V
L
R
Q
-
L
G
L
S
A
-
P
R
V
I
A
V
E
A
H
A
V
G
G
N
W
L
A
---------
S
G
--
G
W
T
------
D
G
-
R
H
R
L
G
T
S
-
P
E
---
K
D
I
G
F
P
Y
H
S
T
---------
W
A
R
G
----
H
-----------------------------
N
R
--------------
E
I
N
E
A
M
M
A
F
--------
S
W
T
S
F
L
-
V
E
H
G
----
T
-----
Y
A
E
W
-
I
D
R
G
R
P
S
---
P
Q
--------------------------
H
H
-
V
W
-----
A
K
Y
L
Q
W
V
A
R
K
--
I
D
L
E
L
V
L
G
K
----
V
R
T
I
R
Q
G
W
S
V
E
V
A
G
A
T
T
E
L
E
A
------
D
G
L
M
I
T
G
P
G
Q
S
T
K
A
L
A
A
H
P
R
-----------
V
L
S
I
A
E
F
W
D
L
A
G
K
R
K
L
P
I
S
---
S
-
R
----
A
A
V
-
I
G
--
G
---
G
E
T
A
G
S
A
L
D
E
L
V
R
H
E
M
--
L
T
I
S
V
I
-----
S
-
P
-
M
A
S
Y
F
E
N
S
L
F
-
S
D
P
T
K
W
N
A
L
S
I
Q
E
R
R
D
V
I
R
-
R
T
D
R
G
V
F
S
V
R
V
Q
E
S
L
L
GDN
R
V
H
H
L
Q
G
R
V
T
--
R
----
I
V
G
--
Q
G
---
D
G
----
V
A
V
T
L
R
N
E
M
-------------------
R
A
D
Q
-
V
H
N
---
F
D
L
-
V
V
D
A
-
T
G
------
G
Q
P
L
W
F
L
D
L
F
D
S
E
S
A
D
-
L
------------
L
------------
E
---
L
A
-
V
G
G
P
L
T
Q
Q
R
I
E
S
S
-
I
G
Y
D
L
A
V
-------------------------------
T
------
G
----
L
G
A
K
L
Y
L
P
N
M
A
A
L
A
Q
G
P
G
F
P
N
-
L
S
C
L
-------
G
E
L
S
D
R
V
L
R
-----------------
23
Fugue
60.66
18%
-104
- C3 -
3RFY
-
CYP38_ARATH
A:
[78-433]
--------------------------------------------------------------G
G
I
L
L
V
A
N
P
---
V
I
P
---------------------------
D
V
S
V
L
-
I
S
G
P
----
P
------
I
K
D
P
-
E
A
L
L
R
Y
-----
A
L
P
----
I
-
D
N
K
A
I
R
E
V
Q
K
P
L
E
D
I
T
D
S
L
K
I
A
G
---------
V
K
--
A
L
D
------
S
V
-
E
R
N
V
R
Q
A
S
R
T
---
L
Q
--------------------
Q
----
G
-----------------------------
K
S
--------------
I
I
V
A
G
F
---------------------
A
----
E
-----
S
K
K
D
-
H
G
N
E
M
I
E
---
K
L
E
A
G
M
Q
D
--
M
----
L
K
-
I
V
E
D
R
K
RDA
V
A
P
-
K
Q
-----
K
E
I
L
K
Y
V
G
G
I
E
E
D
M
V
D
G
F
P
Y
E
----
V
P
E
E
Y
R
--------
N
M
P
L
L
K
G
------
R
A
S
V
D
M
K
V
K
I
K
D
N
P
N
I
E
D
C
V
-----------
F
R
I
V
L
D
G
Y
N
A
P
V
T
A
G
N
F
V
D
---
L
-
V
----
E
R
H
-
F
Y
D
G
M
---
E
I
Q
R
S
D
G
F
V
V
Q
--------
T
G
D
P
E
-----
G
-
P
-
A
E
G
F
I
D
P
S
-----
T
E
K
T
R
T
V
P
L
E
I
M
V
T
G
E
K
------------------------
T
P
F
Y
G
S
--
T
----
L
E
E
--
L
G
---
L
Y
----
K
A
Q
V
V
I
P
-----------
F
N
---
A
F
G
-
T
M
A
M
A
-
R
E
E
---
F
E
N
-
D
S
G
S
-
S
Q
V
F
--------------
W
L
L
K
E
S
-
E
------------
L
------------
T
---
P
S
-------------------------
N
-----
S
N
I
L
-----
D
G
R
Y
A
V
F
G
Y
V
T
D
---------------------
N
E
D
F
L
A
D
L
K
V
G
D
V
-
I
E
S
I
-------
Q
V
V
S
G
L
E
N
-----
L
A
N
P
S
Y
-------
1
PsiBlast_PDB
56.94
26%
-135
- C4 -
3RKO
-
?
N:
[208-406]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--------------
L
M
I
V
G
L
G
F
K
L
S
----
L
V
P
F
H
L
W
T
-
P
D
V
Y
----
Q
-----
G
A
P
A
-
P
V
S
T
F
L
A
---
T
-
A
S
K
I
A
I
FG
V
----
V
M
-
R
L
F
L
Y
A
---
P
V
G
-
D
S
-----
E
A
I
R
V
V
L
-
A
I
I
A
F
A
S
I
I
F
G
N
L
MALS
Q
T
N
I
K
R
L
L
G
Y
S
S
I
S
H
L
G
Y
L
L
V
ALIALQ
T
G
E
M
---
S
M
E
A
V
G
V
Y
L
A
G
Y
L
-----------
F
S
S
L
G
A
F
G
V
V
S
L
M
S
S
P
Y
R
G
---
P
-
D
----
A
D
S
L
F
S
Y
R
G
---
L
F
W
H
R
P
I
L
A
A
V
M
--
T
V
MM
L
S
L
A
G
I
-----
P
-
M
-
T
L
G
F
I
G
K
F
Y
V
L
A
V
G
V
Q
A
H
L
W
W
L
V
G
A
V
V
V
G
S
-
A
I
G
L
Y
Y
Y
L
R
V
A
V
S
L
Y
L
---
H
A
P
E
Q
P
S
N
W
Q
--
Y
----
S
A
G
--
G
I
---
V
V
----
L
I
S
A
L
L
V
L
V
L
-----
G
V
W
P
Q
---
P
L
I
-
S
I
V
R
L
-
A
M
P
---
L
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
42.59
25%
-144
- C4 -
4HE8
-
NQO12_THET8
L:
[217-309]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
----
Q
I
P
L
M
V
W
L
-
P
D
A
M
AGPT
P
-----
V
S
A
L
I
H
A
A
T
M
V
T
AGV
Y
L
I
A
R
S
S
F
--
L
-----------
Y
S
---
V
L
P
-
D
V
-----
S
Y
A
I
A
V
V
G
L
L
T
A
A
Y
G
A
L
S
A
F
G
----
Q
T
D
I
K
K
I
V
A
Y
S
T
I
S
Q
L
G
Y
M
F
L
------
A
A
G
V
G
A
Y
W
V
A
L
F
H
V
F
T
H
A
F
F
-----------
K
A
L
L
F
L
A
S
G
S
V
I
H
A
L
G
G
E
Q
---
D
-
V
----
R
K
M
-
G
G
L
W
K
---
H
L
P
Q
T
R
W
H
A
L
I
G
--
A
L
--
A
L
G
G
L
P
-----
L
-
L
-
S
G
F
W
S
K
D
A
I
L
-
A
A
T
L
T
Y
P
F
G
G
V
G
F
Y
V
G
A
L
L
-
V
A
V
L
T
A
M
Y
A
M
R
W
F
V
L
V
---
F
L
G
E
E
R
G
H
H
H
--
P
----
H
E
A
--
P
P
---
V
M
----
L
W
P
N
H
L
L
A
L
G
-----
S
V
L
A
G
---
Y
L
A
-
L
P
H
P
L
-
P
N
V
---
L
E
P
-
F
L
K
P
-
A
L
A
E
V
--
E
A
H
H
L
S
L
G
A
E
W
G
L
I
A
L
S
-
A
------------
A
------------
V
---
A
L
-
L
G
L
W
A
G
F
V
F
F
Q
R
K
V
F
P
A
W
Y
L
A
--
F
E
-----
A
A
S
R
-----
E
A
F
Y
V
D
R
A
Y
N
A
L
I
V
------
N
----
P
L
K
A
L
A
E
A
L
F
Y
G
D
R
G
L
L
S
G
Y
F
-
G
L
G
G
-------
A
A
R
S
L
G
Q
G
L
A
R
L
Q
T
G
Y
L
R
V
-------
3
PsiBlast_PDB
39.20
25%
-139
- C4 -
4HEA
-
NQO12_THET8
L:
[217-309]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
----
Q
I
P
L
M
V
W
L
-
P
D
A
M
AGPT
P
-----
V
S
A
L
I
H
A
A
T
M
V
T
AGV
Y
L
I
A
R
S
S
F
--
L
-----------
Y
S
---
V
L
P
-
D
V
-----
S
Y
A
I
A
V
V
G
L
L
T
A
A
Y
G
A
L
S
A
F
G
----
Q
T
D
I
K
K
I
V
A
Y
S
T
I
S
Q
L
G
Y
M
F
L
------
A
A
G
V
G
A
Y
W
V
A
L
F
H
V
F
T
H
A
F
F
-----------
K
A
L
L
F
L
A
S
G
S
V
I
H
A
L
G
G
E
Q
---
D
-
V
----
R
K
M
-
G
G
L
W
K
---
H
L
P
Q
T
R
W
H
A
L
I
G
--
A
L
--
A
L
G
G
L
P
-----
L
-
L
-
S
G
F
W
S
K
D
A
I
L
-
A
A
T
L
T
Y
P
F
G
G
V
G
F
Y
V
G
A
L
L
-
V
A
V
L
T
A
M
Y
A
M
R
W
F
V
L
V
---
F
L
G
E
E
R
G
H
H
H
--
P
----
H
E
A
--
P
P
---
V
M
----
L
W
P
N
H
L
L
A
L
G
-----
S
V
L
A
G
---
Y
L
A
-
L
P
H
P
L
-
P
N
V
---
L
E
P
-
F
L
K
P
-
A
L
A
E
V
--
E
A
H
H
L
S
L
G
A
E
W
G
L
I
A
L
S
-
A
------------
A
------------
V
---
A
L
-
L
G
L
W
A
G
F
V
F
F
Q
R
K
V
F
P
A
W
Y
L
A
--
F
E
-----
A
A
S
R
-----
E
A
F
Y
V
D
R
A
Y
N
A
L
I
V
------
N
----
P
L
K
A
L
A
E
A
L
F
Y
G
D
R
G
L
L
S
G
Y
F
-
G
L
G
G
-------
A
A
R
S
L
G
Q
G
L
A
R
L
Q
T
G
Y
L
R
V
-------
4
PsiBlast_PDB
28.65
33%
43
- C4 -
4OO1
1
RRP6_YEAST
J:
[170-247]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
I
I
W
L
Q
R
D
L
G
L
Y
V
V
G
L
--
F
D
T
Y
H
A
S
K
A
I
G
-----
L
P
R
H
S
L
A
Y
L
L
E
N
F
A
------
N
----
F
K
T
S
K
K
Y
Q
L
A
D
W
R
I
R
P
L
S
K
P
M
-
T
A
Y
A
-------
R
A
D
T
H
F
L
L
N
I
Y
D
Q
L
R
N
K
L
I
-------
12
HHSearch
27.03
8%
26
- C4 -
3RKO
-
NUOK_ECOBD
K:
[11-48]
-----------------------------------------------------------------------------------------------------------------------------------
A
A
I
L
F
-----
V
L
G
L
T
G
L
V
-
I
R
R
N
L
L
F
M
L
I
G
L
E
I
M
I
N
A
S
A
L
A
F
---------
V
V
--
A
G
S
------
Y
W
-
G
Q
T
D
G
Q
V
M
Y
I
---
L
A
I
S
L
A
A
A
E
A
---------
S
I
G
L
----
A
-----------------------------
L
L
--------------
L
Q
L
H
R
R
R
Q
N
L
N
----
I
D
S
V
S
E
M
R
-
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
Fugue
23.29
31%
145
* C4 *
4H13
1
PETL_MASLA
E:
[1-32]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
L
G
A
V
-----------
F
Y
I
V
F
I
A
L
F
F
G
I
A
V
G
I
I
F
A
---
I
-
K
----
S
I
K
-
L
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
Fugue
22.65
31%
139
- C4 -
2E74
1
PETL_MASLA
E:
[1-32]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
L
G
A
V
-----------
F
Y
I
V
F
I
A
L
F
F
G
I
A
V
G
I
I
F
A
---
I
-
K
----
S
I
K
-
L
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
22.25
11%
332
- C4 -
1N7L
-
PPLA_RABIT
A:
[24-51]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
R
Q
N
L
Q
N
L
F
I
N
F
A
L
I
-------
L
I
F
L
L
L
I
A
I
I
V
M
L
L
------------
10
HHSearch
13.33
25%
445
- C5 -
3R3Q
1
STP22_YEAST
A:
[80-99]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
H
----
S
I
P
V
I
M
W
V
-
P
S
M
Y
----
P
-----
V
K
P
P
-
F
I
S
I
N
L
E
---
N
F
D
M
N
T
I
S
--
S
----
S
L
-
P
I
Q
E
Y
I
---
D
S
N
-
G
W
-----
I
A
L
P
I
L
H
A
W
D
P
A
A
M
N
L
I
M
V
V
Q
----
E
L
M
S
L
L
H
E
P
P
Q
D
Q
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
12.89
19%
275
* C5 *
3OBQ
1
TS101_HUMAN
A:
[68-93]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
----
N
I
P
I
C
L
W
L
-
L
D
T
Y
----
P
-----
Y
N
P
P
-
I
C
F
V
K
P
T
---
S
S
M
T
I
K
T
G
--
K
----
H
V
-
D
A
N
G
K
I
---
Y
L
P
-
Y
L
-----
H
E
W
K
H
P
Q
S
D
L
L
G
L
I
Q
V
M
I
V
V
F
----
G
D
E
P
P
V
F
S
R
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
6.41
27%
743
- C5 -
2P08
-
?
A:
[8-22]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
----
A
F
P
F
H
F
A
F
-
S
R
N
R
----
E
-----
I
V
Q
T
-
G
E
V
L
E
R
I
---
S
P
E
P
L
V
G
K
--
L
----
I
E
-
Q
H
F
Q
I
N
---
R
P
K
-
I
L
-----
I
D
F
D
A
I
S
K
Q
P
R
A
L
F
I
L
E
F
L
H
N
----
G
M
Q
L
K
G
Q
M
M
Y
Q
P
E
E
E
V
I
F
F
L
G
------
S
P
W
I
T
D
T
T
S
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------