@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0051: (2015-11-28 )
MLLNFNASFSNLYTRNGLIKLDEAFLDYIKSCDEDLFCSLIEAREETTPSSASFQYWTSESRKKEPVSSKNTASSSVSFQCATLESRKHPMSASQMTDSQLIIDLAYLLDGFIAKLFNVEKEIEELKKKHNDFAVIYKCKRLFVQRYALKKYADTENIDIDYVTSELNCFLTLPTTEKIFAEQVMHWFEDRENHKDEIELAAQYAAWRVKNKRSILFNIHRKIDHENLISFSKKEVDKVEVLYSNKIKRRYGFDLTSEKVSLDKALDNAHYCIFCHKQNKDSCSKGLLETSLSFQHMTLKSKKKEEWIPVSSTGMTGKCTQMSEGCIKSLLNNYNTFKRSPLKVELHGCPLEQKISEMNLVKSEGYNIASLAIAMIDNPLCAATGYKICNDCMNSCIYQKQEPVNVPMVETRILDDVLSLPYGFEIYSLLSRWNPLNFQQPLPKENTGKNVLVVGLGPAGFNLAHHLLNDGHNVIAIDGLKIEPLNDDLQPIKDFKHEKLSERIADGFGGVAEYGITSRWDKNYLKIIRLLLERRENFAIYGGIRFCGTVTVDDAFNLGFNHIALALGSGKPRMIKIKNILARGVRMASDFLMSLQLTGALKLDSLANLQVRMPIVIIGAGLTAIDTATEALAYYPIQAEKFLLRYEVLVDKYGKDYVEKDWTEEEREIADEFISHAQLICKEKELAKKENREAKILELMQSLGGVKVVYRKELKDSPSYRLNSEEVQNALSEGIYFIENSEPVEIMTDKYSHIESIKLIDTKSHEIKYIKARSILIAAGTEPNTVIATEDKKHFKLSNGYFTHLNSLGEEIDPILSPKMQNKDRILVYKQGGRTISFFGDLHPSYSGSVVKAMASAKNGYPIISQLLSGANTATVIPISSPITSVLNTGISASHTQLYECYNIRVTFITKDVISVPRHTAIQTLWLKSNLHQKGYHSSSSFLSPQCVTLGFSKIGYKQTQYATFSAKLTKNWTPVLRTGMTLSHRTNEEFFNRIKEQFTAKVVKVQYLTDKVVEVVIKAPLAAKNFQPGQFFRLQNFETNSRKINNTTFAMEGIAVTGTEVNKKKGLISTIVLETGGSTNLCRYLREGEQIILMGPTGRPTEVY
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180---...------.....190.......200.......210...------...-.220.......230.......240.......250....-...260.......270.-----......280.......290.......300.......310......---.320.......330.......340.......350.......360...-.-...370.......380---....----...390-.---........--400-...-......410.......420.......430.......440-.........--450.......460.......470-.--.--....---..480-...--..--..490....-...500...-....510..-----.--.-.-----..520.------.....-.----..-----------530.----.---.....540...-.---.-----------.-.-.550-----.......560.......570..--------.-....580.--.---.....---..590.......600..-..-.---..-.610.......620-........630...-------------------.-...640.-------......650.......660.......670.......-680.......690.......700...------....710-..-.-.--..-..720.....----------..-----.-730--.-.......740...-....750------..-----.......760.---------------......770.......780.---..-.--...--790.......800.......810........820.......830...----....840...---.---------.---------..850.......860.......870.----......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
L
L
NFNA
S
F
S
NLYTRNG
L
I
K
L
D
E
A
F
L
D
Y
I
K
SC
D
E
D
L
F
C
S
L
I
E
A
R
EETTPSSA
S
F
Q
Y
WTSESRKKEPVSSKNTASSS
V
S
F
Q
C
A
TLESRKHPMSASQMTD
S
Q
L
I
I
D
L
A
Y
L
L
D
G
F
I
A
K
L
F
N
V
E
K
E
I
E
E
L
K
K
KHND
F
A
V
I
Y
K
C
K
R
L
F
V
Q
R
Y
A
L
K
KYADTEN
I
D
I
D
Y
V
TSE
L
N
C
F
L
TLP
T
T
E
K
I
F
A
----
E
Q
V
------
M
H
W
F
E
DREN
H
K
D
E
I
E
L
A
A
Q
Y
A
A
W
R
VKNK
R
S
I
------
L
F
N
-
I
H
R
KI
D
H
E
N
L
I
S
F
S
K
KE
V
D
K
V
E
V
L
Y
SN
K
I
K
R
RYGFDLT-SEK
V
S
L
D
K
ALDNA
H
Y
C
I
-----
F
C
HKQNK
D
S
C
S
K
G
L
L
E
TSLS
F
Q
H
M
TLKSKKKEE
W
I
PVSSTGMTGK---
C
T
Q
M
S
E
G
C
I
K
S
L
L
NNY
N
T
FKRS
P
L
K
V
E
LHGC
P
L
E
Q
K
I
S
E
MNLVKSEG-Y-
N
I
A
S
L
A
I
A
MIDNPLCA---AT
G
Y
----
K
I
C
N
---
D
---
C
M
N
S
C
I
YQ--K---QEP-VNV
P
M
V
E
T
R
I
L
D
D
V
LSLPY
G
F
E
I
Y
S
L
L
S
RWNPLNFQQ---PLPKENTG
K
--
N
V
L
V
V
GLGP
A
G
F
N
L
A
H
H
L
L
NDG--H--
N
--
V
I
A
I---D
G
L
K
I-EPL--ND--
D
L
Q
P
I
K
D
F
K
-
H
E
K
L
S
E
R
I
A
-
D
GFG
G
V
A
EY-----G--I-T-----SRW--
D
------
K
N
Y
L
K
-
I
----
I
R
-----------
L
L
L
E
----R---RE
N
F
A
I
Y
-GG
I
-
R
---
F
-----------
C
-
G
-
T
V
T
V-----D
D
A
F
NLG
F
N
H
I
A
L
ALGSGK
P
R
M
--------
I
-
K
I
K
N
I
--
L
--
A
---
R
G
V
R
M
---
A
S
D
F
L
M
S
L
Q
L
TG
A
-
L
KL-DS-L---AN-
L
Q
V
R
M
P
I
V
I
IGAG--
L
T
A
I
D
T
A
T
E
A
L
A
YY-------------------P-I
Q
A
E
K
F
L
-------
L
R
Y
E
V
L
V
D
KY
G
K
D
Y
V
EKDW
T
E
E
E
R
E
I
A
D
E
F
I
S
H
A
Q
L
-
I
C
K
E
K
E
L
A
K
KENR
E
A
K
I
L
E
L
M
Q
SLG
G
------
V
K
V
V
Y
R
--
K
E-L-K--DS-PSY-RL
N
S
E
E
----------
V
Q
-----
N
-
A
-
L
--S-E
G
I
Y
F
IENSE
P
V
E
-
I
MTDK--------YS-----HI
E
S
I
K
L
I
DTK---------------SH
E
I
K
Y
I
K
A
R
S
I
L
I
A
AGTEP---
N
T
-
V
--
I
AT--EDK
K
H
F
K
LSN
G
Y
F
T
H
L
N
S
L
G
E
E
-
I
D
P
ILSPKMQNK
D
R
I
L
V
Y
KQGG
R
T
----
I
S
F
FGDLHPS---Y---------S---------
G
S
V
V
K
A
M
A
SAKN
G
Y
P
I
I
S
Q
L
LSGAN
T
----
A
T
V
I
PIS
S
P
I
T
S
V
L
NTGISA
S
H
T
Q
L
Y
E
C
Y
N
I
R
V
T
F
I
T
K
D
V
ISVPR
H
T
A
I
Q
T
L
W
LKSNLHQKGYHSSSSFLSPQ
C
V
T
LG
F
S
KIGYKQ
T
Q
Y
A
T
F
S
A
KLTKNW
T
P
V
LRTGMTLSHRT
N
E
E
F
F
N
R
I
K
E
Q
F
T
A
K
V
V
K
V
Q
Y
L
T
D
K
V
V
E
V
V
I
KAPLAAKNFQPG
Q
F
F
R
L
QNFETNS
R
K
INN
T
T
F
A
M
E
G
I
A
V
TGTEVNKKKG
L
I
S
T
I
V
L
ETGG
S
T
N
L
C
R
Y
L
REG
E
Q
I
I
L
MGPTGRPTEVY
21
HHSearch
88.32
22%
-58
- C1 -
2VDC
-
GLTD_AZOBR
G:
[29-448]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
C
Q
V
H
C
P
V
S
N
N
I
P
D
W
L
K
L
T
S
E
G
-
R
-
L
E
E
A
Y
E
V
S
Q
A
T
N
N
F
P
E
---
I
C
G
-----
R
I
C
P
QDR
L
---
C
E
G
N
C
V
I
E
QS
T
---
H
G
A
-
V
T
I
G
S
V
E
K
Y
I
N
D
T
A
W
D
Q
G
-----------
W
V
K
P
-------
R
T
P
S
R
E
L
G
L
--
S
V
G
V
I
G
A
G
P
A
G
L
A
A
A
E
E
L
R
A
K
G
--
Y
--
E
--
V
H
V
Y
---
D
R
Y
D
--------------------------------
R
M
G
G
L
L
V
Y
-----
G
--
I
-
P
G----
F
K
L
--
E
------
K
S
V
V
E
-
R
R---
V
K
-----------
L
L
A
D
---------
A
G
V
I
Y
H
-
P
N
F
-
E
---
V
-----------
G
-
R
-
D
A
S
L
-----
P
E
-
L
R
R
K
H
V
A
V
L
V
A
T
G
V
Y
K
A
R
D
--------
I
-
K
A
P
G
S
--
G
--
L
---
G
N
I
V
A
---
A
L
D
Y
L
T
T
S
N
K
V
S
L
-
G
D
T
V
E
A
-
Y
ENG
S
L
-
N
A
A
G
K
H
V
V
V
L
G
G
G
--
D
T
A
M
D
C
V
R
T
A
I
R
----------------------------------------------
Q
G
A
-------------------------------------------------
T
S
------
V
K
C
L
Y
R
--
R
D
-
R
-
K
--
N
M
-
P
G
S
----
Q
R
E
----------
V
A
-----
H
-
A
-
E
--
E
-
E
G
V
E
F
I
W
Q
A
A
P
E
G
-
F
T
G
D
----------
T
-----
V
V
T
G
V
R
A
V
R
I
H
LGVADATGRQTPQVI
E
G
S
E
F
T
V
Q
A
D
L
V
I
K
A
L
G
F
E
P
---
E
D
-
L
PN
A
F
D
--
E
P
E
--
L
K
V
--------
T
R
W
G
T
L
L
V
D
H
------------
R
T
K
M
T
N
M
D
G
----
V
F
A
A
G
D
I
V
R
----
G
---------
A
---------
S
L
V
V
W
A
I
R
D
G
R
D
A
A
E
G
I
H
A
Y
A
K
A
K
A
E
----
A
P
V
A
V
A
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
74.03
20%
-75
- C1 -
1GTE
3
DPYD_PIG
A:
[86-528]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
C
Q
K
S
C
P
T
H
L
D
I
K
S
F
I
T
S
I
S
N
K
-
N
-
Y
Y
G
A
A
K
M
I
F
S
D
N
P
L
G
L
---
T
C
G
-----
M
V
C
P
---
T
SDL
C
V
G
G
C
N
L
Y
AT
E
---
E
G
S
-
I
N
I
G
G
L
Q
Q
F
A
S
E
V
F
K
A
M
N
I
P
Q
-------
I
R
N
P
C
L
P
S
Q
---
E
K
M
P
E
A
Y
S
A
--
K
I
A
L
L
G
A
G
P
A
S
I
S
C
A
S
F
L
A
R
L
G
--
Y
S-
D
--
I
T
I
F
---
E
K
Q
E
--------------------------------
Y
V
G
G
L
S
T
S
-----
E
--
I
-
P
Q----
F
R
L
--
P
------
Y
D
V
V
N
-
F
E
---
I
E
-----------
L
M
K
---------
D
L
G
V
K
I
I
-
C
G
K
-
S
---
L
-----------
S
-
E
N
E
I
T
L
-----
N
T
L
K
E
E
G
Y
K
A
A
F
I
G
I
G
L
P
E
P
K
T
--------
D
-
D
I
F
Q
G
LT
Q
--
D
---
Q
G
F
Y
T
---
S
K
D
F
L
P
L
V
A
K
S
S
K
-
A
G
M
-
C
A
C
H
---
S
P
L
P
S
I
R
G
A
V
I
V
L
G
A
G
--
D
T
A
F
D
C
A
T
S
A
L
R
----------------------------------------------
C
G
A
-------------------------------------------------
R
R
------
V
F
L
V
F
R
--
K
G
-
F
-
V
--
N
I
-
R
A
V
----
P
E
E
----------
V
E
-----
L
-
A
-
K
--
E
-
E
K
C
E
F
L
P
F
L
S
P
R
K
-
V
I
V
K
---------
G
G
-----
R
I
V
A
V
Q
F
V
R
T
E
Q
D
ETG
K
W
N
E
D
-----
E
D
Q
I
V
H
L
K
A
D
V
V
I
S
A
F
G
S
V
L
---
R
D
-
P
--
K
V
K
--
E
A
L
S
P
I
K
F
N
--------
R
W
D
L
P
E
V
D
P
------------
E
T
M
Q
T
S
E
P
W
----
V
F
A
G
G
D
I
V
G
----
M
---------
A
---------
N
T
T
V
E
S
V
N
D
G
K
Q
A
S
W
Y
I
H
K
Y
I
Q
A
Q
Y
G
ASVS
A
K
P
E
L
P
L
F
Y
T
P
V
D
L
V
D
I
S
V
E
M
A
G
L
K
F
I
N
P
F
G
L
A
S
A
A
P
T
T
S
S
S
M
I
R
R
A
F
E
A
G
W
G
F
A
L
T
K
T
F
S
L
D
K
D
I
V
T
N
V
S
P
R
I
V
R
G
T
T
S
G
P
M
Y
G
P
G
Q
S
S
F
L
N
I
E
L
I
S
E
K
T
A
A
Y
W
C
Q
S
V
T
E
L
K
A
D
F
P
D
N
I
V
I
A
S
I
M
C
S
Y
N
K
N
D
W
M
E
L
S
R
K
A
E
A
S
G
A
D
A
L
E
L
N
L
S
C
P
H
G
M
G
L
A
C
G
Q
D
P
E
L
V
R
N
I
C
R
W
V
R
Q
A
V
Q
I
P
F
F
A
K
L
T
P
N
V
T
D
I
V
S
I
A
R
A
A
K
E
G
G
A
D
G
V
T
A
T
N
T
V
S
G
L
M
G
L
K
A
D
G
T
P
W
P
A
28
HHSearch
73.52
17%
-57
- C1 -
3K30
3
?
A:
[306-678]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
A
M
V
R
Q
I
K
A
G
I
L
-
D
L
I
G
A
A
R
P
S
I
A
D
P
F
L
P
N
K
I
R
D
G
R
LNLI
R
E
C
I
---
G
---
C
N
-
I
C
V
S
G
D
-
L
T
--
M
S
P
-
I
----------
R
C
T
Q
N
P
S
M
G
E
E
W
R
---
R
G
W
H
P
E
-------
R
I
R
A
K
E
S
D
A
--
R
V
L
V
V
G
A
G
P
S
G
L
E
A
A
R
A
L
G
V
R
G
--
Y
--
D
--
V
V
L
A
---
E
A
G
R
D
--------------------------------
L
G
G
R
V
T
Q
-----
E
S
A
L
-
P
G----
L
S
A
--
W
------
G
R
V
K
E
-
Y
----
R
E
-----------
A
V
L
A
----
E
---
L
P
N
V
E
I
Y
-
R
E
--------------------
S
-
P
M
T
G
-----
D
D
I
V
E
F
G
F
E
H
V
I
T
A
T
G
A
-
T
W
R
T
--------
D
-
G
V
A
R
F
--
H
--
T
TAL
P
I
-
A
E
---
G
M
Q
V
L
G
P
D
D
L
----
F
A
---------
G
R
-
L
P
D
G
K
K
V
V
V
Y
D
D
D
HY
Y
L
G
G
V
V
A
E
L
L
A
Q
K
--------------------
G
-
Y
E
---------------------------------------------------------------------------------
V
S
I
V
T
P
--
G
A
-
Q
-
V
SS
W
T
N
N
T
F
---
E
V
N
R
----------
I
Q
-----
R
-
R
L
I
--
E
-
N
G
V
A
R
V
T
D
H
A
V
V
A
-
V
G
A
G
-------------------
G
V
T
V
R
D
T
Y
---------------
A
S
I
E
R
E
L
E
C
D
A
V
V
M
V
T
A
R
L
P
---
R
E
-
E
--
L
Y
L
--
D
L
V
--
A
R
---------
R
D
-----------------------
A
G
E
I
A
S
----
V
R
G
I
G
D
A
W
A
--------------
P
---------
G
T
I
A
A
A
V
W
S
G
R
R
A
A
E
E
F
D
A
V
L
P
S
N
D
E
----
V
P
F
R
R
E
V
T
Q
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
72.94
19%
-57
- C1 -
1CJC
1
ADRO_BOVIN
A:
[6-399]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
--
Q
I
C
V
V
G
S
G
P
A
G
F
Y
T
A
Q
H
L
L
K
H
H
SR
A
--
H
--
V
D
I
Y
---
E
K
Q
L
V
--------------------------------
P
F
G
L
V
R
F
-----
G
--
V
-
A
-----
P
D
H
PE
V
------
K
N
V
I
N
-
T
----
F
T
-----------
Q
T
A
R
--------
S
D
R
C
A
F
Y
-
G
N
V
-
E
---
V
-----------
G
-
R
-
D
V
T
V
-----
Q
E
L
-
Q
D
A
Y
H
A
V
V
L
S
Y
G
A
E
D
H
Q
A
--------
L
-
D
I
P
G
E
--
E
--
L
---
P
G
V
F
S
---
A
R
A
F
V
G
W
Y
N
G
L
P
E
-
N
---
R
E
-
L
---
A
P
-
D
L
S
C
D
T
A
V
I
L
G
Q
G
--
N
V
A
L
D
V
A
R
I
L
L
T
P
P
DHLEKTDIT
E
A
A
L
G
A
L
R
Q
S
R
V
K
T
V
W
---------------
I
V
G
R
R
G
P
--
L
Q
V
A
F
T
I
K
E
L
R
---
E
M
I
Q
L
P
G
T
R
P
M
L
D
---------
P
A
D
F
-
L
G
L
Q
--
D
R
------
I
K
E
A
A
R
P
R
K
R
L
M
-
E
--
L
L
-
L
R
T
-
A
T
E
K
P
G
----------
V
E
E
A
A
R
R
A
-
S
-
A
--
S
-
R
A
W
G
L
R
F
F
R
S
P
Q
Q
-
V
L
P
S
P
--------
D
G
R----
R
A
A
G
I
R
L
A
V
T
R
L
E
G
IGEA
T
R
A
V
P
---
T
G
D
V
E
D
L
P
C
G
L
V
L
S
S
I
G
Y
K
S
---
R
P
-
I
--
D
P
-----
S
--
V
P
F
D
--------
P
K
L
G
V
V
P
N
M
------------
E
G
R
V
V
D
V
P
G
----
L
Y
C
S
G
W
V
K
R
G
---
P
---------
T
---------
G
V
I
T
T
T
M
T
D
S
F
L
T
G
Q
I
L
L
Q
D
L
K
A
G
H
L
----
P
S
G
P
R
P
G
S
A
F
I
K
A
L
L
D
S
R
G
V
W
P
V
S
F
S
D
W
E
K
L
D
A
E
E
V
S
R
G
Q
A
S
G
K
P
R
E
K
L
L
D
P
Q
E
M
L
R
L
L
G
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
71.93
13%
-17
- C1 -
1PS9
8
FADH_ECOLI
A:
[1-671]
--------------------------------------------------------------
S
Y
P
S
L
F
A
P
L
D
L
G
F
T
T
L
K
N
R
V
L
M
G
S
M
H
T
G
L
E
E
Y
P
D
G
A
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R
L
A
A
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A
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G
G
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A
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G
G
A
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A
V
H
Q
E
G
G
----
K
I
A
L
Q
I
L
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R
Y
S
Y
Q
P
H
L
V
A
PSAL
Q
A
P
------
I
N
R
F
V
P
H
E
L
S
H
E
E
I
L
Q
L
I
D
N
F
A
R
C
A
Q
L
A
R
E
A
------
G
Y
D
G
V
E
V
M
G
S
E
G
Y
L
I
N
E
F
L
T
L
-------
R
T
N
Q
R
S
D
Q
W
G
G
D
Y
R
-
N
R
M
R
F
A
V
E
V
V
R
A
V
R
E
R
V
GND
F
I
I
I
Y
R
L
S
M
L
D
L
V
E
D
G
G
T
F
A
E
T
V
E
L
A
Q
A
I
E
A
A
G
A
T
I
I
N
T
G
I
G
W
H
E
A
R
---
I
P
T
I
A
T
P
V
P
R
G
A
F
S
W
V
T
R
K
L
K
G
H
V
S
L
P
L
V
T
T
N
R
I
N
D
P
Q
V
A
D
D
I
L
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R
G
-
D
A
D
M
V
S
M
A
R
P
F
L
A
D
A
E
L
L
---
S
K
A
Q
----
S
G
R
A
---
D
---
E
I
N
T
C
I
G
C
--
N
---
Q
-
A
-
C
L
D
Q
I
F
V
G
K
V
T
S
C
L
V
N
P
R
A
C
H
E
------------
T
K
M
---
P
I
L
P
A
V
Q
K
K
--
N
L
A
V
V
G
A
G
P
A
G
L
A
F
A
I
N
A
A
A
R
G
--
H
--
Q
--
V
T
L
F
---
D
A
-------------------------------
H
-
S
E
I
G
G
Q
F
N
I
-----
A
--
K
-
Q
-----
I
P
G
--
K
------
E
E
F
Y
E
-
T
----
L
R
-----------
Y
Y
R
R
----
M
---
I
E
V
T
-----
G
V
-
T
---
L
-----------
K
-
L
-
N
H
T
V
-----
T
A
D
Q
L
Q
A
F
D
E
T
I
L
A
S
G
-
I
V
P
R
T
--------
P
-
P
I
D
G
I
--
D
--
H
---
P
K
V
L
S
---
Y
L
D
V
L
R
D
-------------------
K
-
A
P
V
G
N
K
V
A
I
I
G
C
G
--
G
I
G
F
D
T
A
M
Y
L
S
Q
------------------------
P
G
E
S
T
S
-------
Q
N
I
A
G
F
C
N
E
W
G
---------------
I
D
S
S
L
Q
Q
A
G
G
-
L
S
P
Q
G
M
Q
I
P
R
S
P
R
Q
I
V
M
L
Q
R
K
A
S
K
P
G
QGLGKT
T
G
W
I
H
R
--
T
T
-
L
-
L
--
S
R
-
G
V
K
-
M
I
P
G
V
S
----------
Y
Q
-----
K
-
I
-
D
--
D
-
D
G
L
H
V
V
I
N
G
E
T
Q
V
-
L
A
V
D
N
--------
V
V
-----
I
C
A
G
Q
E
P
N
R
A
L
---------------
A
Q
P
L
I
D
S
G
K
T
V
H
L
I
G
G
C
D
V
A
MEL
D
A
-
R
--
R
A
I
--
A
Q
G
T
R
L
A
L
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
68.95
19%
-65
- C1 -
3EF6
9
TODA_PSEP1
A:
[3-336]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
H
V
A
I
I
G
N
G
V
G
G
F
T
T
A
Q
A
L
R
A
E
G
--
F
E
G
R
--
I
S
L
I
---
G
D
E
P
H
-
L
P
Y
--
D
R
-------------
P
S
L
S
K
A
V
----
L
D
G
S
L
E
R
-----
P
-----------------------
P
I
L
A
-
E
----
A
D
-----------
W
Y
G
E
---------
A
R
I
D
M
L
-
T
G
P
-
E
---
V
TALDVQ-----
T
-
R
-
T
I
S
L
-----
D
D
G
T
T
L
S
A
D
A
I
V
I
A
T
G
S
-
R
A
R
T
--------
M
-
A
L
P
G
S
--
Q
--
L
---
P
G
V
V
T
---
L
R
T
Y
G
D
V
Q
V
L
-----
R
---------
D
S
-
W
T
S
A
T
R
L
L
I
V
G
G
G
--
L
I
G
C
E
V
A
T
T
A
R
K
L
--------------------
G
-
L
S
V
T
-
I
L
-------
E
A
G
D
E
L
L
V
R
V
----------------------------------------------------------------------------
L
-
G
R
R
---
I
G
A
W
----------
L
R
-----
G
-
L
L
T
--
E
-
L
G
V
Q
V
E
L
G
T
G
V
V
G
-
F
S
G
E
----------
G
-----
Q
L
E
Q
V
M
A
S
D
------------------
G
--
R
S
F
V
A
D
S
A
L
I
C
V
G
A
E
P
---
A
D
-
Q
--
L
A
R
--
Q
A
G
--
L
A
C
D
---------
R
G
V
I
-
V
D
H
-------------
C
G
A
T
L
A
K
G
----
V
F
A
V
G
D
V
A
S
W
---
P
LRA
G
G
R
R
S-
L
---------
E
T
Y
M
N
A
Q
R
Q
A
A
A
V
A
A
A
I
L
G
K
N
V
--------
S
A
P
Q
L
P
V
S
W
T
E
I
A
G
H
R
M
Q
M
A
G
D
I
E
G
P
G
D
F
V
S
R
G
M
P
G
S
G
A
A
L
L
F
R
L
Q
E
R
R
I
Q
A
V
V
A
V
D
A
P
R
D
F
A
L
A
T
R
L
V
E
A
R
A
A
I
E
P
A
R
L
A
D
L
S
N
S
M
R
D
F
V
---------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
68.21
17%
-74
- C1 -
1FL2
5
AHPF_ECOLI
A:
[2-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
--
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
I
Y
S
A
R
K
G
--
I
--
R
--
T
G
L
M
---
G
E
R
-
F
-
G
G
Q
--
I
L
--
D
T
V
D
I
E
N
Y
I
-
S
--------------------------
V
-
P
-----
K
T
E
--
G
------
Q
K
L
A
G
-
A
----
L
K
-----------
V
H
V
D
--------
E
Y
D
V
D
V
I
-
D
S
Q
-
S
AS
K
L
I
P
AAVEG
G
---
L
-
H
-
Q
I
E
T
-----
A
S
G
A
V
L
K
A
R
S
I
I
V
A
T
G
A
-
K
W
R
N
--------
M
-
N
V
P
G
E
--
D
--
Q
YRT
K
G
V
T
Y
---
C
P
H
C
----
D
----------------
G
P
-
L
F
K
G
K
R
V
A
V
I
G
G
G
--
N
S
G
V
E
A
A
I
D
L
A
G
I
--------------------
V
-
E
---------------------------------------------------------------------------
H
------
V
T
L
L
E
F
--
A
P
-
E
-----
M
-
K
A
-----
D
Q
V
----------
L
Q
-----
D
-
K
-
L
R
S
L
-
K
N
V
D
I
I
L
N
A
Q
T
T
E
-
V
K
G
D
G
---------
S
-----
K
V
V
G
L
E
Y
R
D
R
V
---------------
S
G
D
I
H
N
I
E
L
A
G
I
F
V
Q
I
G
L
L
P
---
N
T
-
N
--
W
L
E
--
G
A
---
V
E
R
N
--------
R
M
G
E
I
I
I
D
A
-------------
K
C
E
T
N
V
K
G
----
V
F
A
A
G
D
C
T
T
V
---
P
---------
Y
---------
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
T
K
T
----
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
67.48
17%
-69
- C1 -
1HYU
4
AHPF_SALTY
A:
[207-519]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
K
R
D
A
Y
--
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
V
Y
S
A
R
K
G
--
I
--
R
--
T
G
L
M
---
G
E
R
F
--
G
G
Q
--
V
L
--
D
T
V
D
I
E
N
Y
I
-------------------------
S
--
V
-
P
-----
K
T
E
--
G
------
Q
K
L
A
G
-
A
----
L
K
-----------
A
H
V
S
--------
D
Y
D
V
D
V
I
-
D
S
Q
-
S
---
A
S
K
L
V
P
AATEG
G
L
-
H
-
Q
I
E
T
-----
A
S
G
A
V
L
K
A
R
S
I
I
I
A
T
G
A
-
K
W
R
N
--------
M
-
N
V
P
G
E
--
D
--
Q
YRT
K
G
V
T
Y
---
C
P
H
C
----
D
----------------
G
P
-
L
F
K
G
K
R
V
A
V
I
G
G
G
--
N
S
G
V
E
A
A
I
D
L
A
G
I
--------------------
V
-
E
---------------------------------------------------------------------------
H
------
V
T
L
L
E
F
--
A
P
-
E
-
M
---
K
-
A
------
D
Q
V
----------
L
Q
-----
D
K
V
-
R
--
S
L
K
N
V
D
I
I
L
N
A
Q
T
T
E
-
V
K
G
D
G
---------
S
-----
K
V
V
G
L
E
Y
R
D
R
V
---------------
S
G
D
I
H
S
V
A
L
A
G
I
F
V
Q
I
G
L
L
P
---
N
T
-
H
--
W
L
E
--
G
A
---
L
E
R
N
--------
R
M
G
E
I
I
I
D
A
-------------
K
C
E
T
S
V
K
G
----
V
F
A
A
G
D
C
T
T
V
---
P
---------
Y
---------
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
T
K
I
----
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
67.38
12%
-54
- C1 -
1HYU
4
AHPF_SALTY
A:
[1-521]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
D
T
N
M
K
T
Q
L
R
A
Y
L
E
K
-
L
T
K
P
V
E
L
I
A
T
L
D
D
S
A
K
S
A
E
I
K
E
L
L
A
E
I
A
-----
E
L
S
D
K
V
T
F
K
E
D
N
T
---
L
P
V
R
K
P
S
F
L
I
T
N
P
G
S
Q
Q
G
P
R
F
A
--
G
S
P
L
G
-----
H
E
F
T
S
L
V
L
A
L
L
W
T
G
G
H
P
S
K
E
A
Q
S
L
L
E
Q
I
R
D
I
D
G
D
F
E
F
E
T
Y
Y
S
L
S
C
-
H
-
N
C
P
D
V
V
Q
A
L
N
---
L
M
A
---
V
L
N
P
----
R
I
K
H
---
T
---
A
I
D
G
G
T
F
Q
--
N
---
E
I
T
E
R
N
V
M
G
V
P
A
V
F
V
N
G
K
E
F
G
Q
G
R
M
T
L
T
E
I
V
A
K
V
D
T
G
A
E
K
R
---
A
A
E
A
L
N
K
R
D
AY
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
V
Y
S
A
R
K
G
--
I
--
R
--
T
G
L
M
G
ER
F
G
G
Q
V
-
L
D
---
T
V
--
D
I
E
N
Y
I
S
V
P
-
K
T
E
G
Q
K
L
A
G
-
A
L
K
A
H
V
S
D
Y
-----
D
--
V
-
D
-----
V
I
D
--
S
------
Q
S
A
S
K
-
L
----
V
P
-----------
A
A
T
E
----
G
---
G
L
----------------------------
H
-
Q
I
E
T
-----
A
S
G
A
V
L
K
A
R
S
I
I
I
A
T
G
A
K
W
R
N
M
NV------
P
-
G
E
D
Q
Y
--
R
--
T
---
K
G
V
T
Y
---
C
P
H
C
D
--------------------
G
P
-
L
F
K
G
K
R
V
A
V
I
G
G
G
--
N
S
G
V
E
A
A
I
D
L
A
G
I
------------------------------------------------------------------
V
E
H
V
T
L
-
L
E
F
A
P
E
M
K
A
D
Q
V
L
Q
D
K
V
R
S
------------------------------------------------------------------
L
-
K
N
V
D
I
I
L
N
A
Q
T
T
E
-
V
K
G
D
G
---------
S
-----
K
V
V
G
L
E
Y
R
D
R
V
---------------
S
G
D
I
H
S
V
A
L
A
G
I
F
V
Q
I
G
L
L
P
---
N
T
-
H
--
W
L
E
--
G
A
L
E
----------------------------
R
N
R
M
G
E
I
I
I
D
A
K
C
E
T
SVKG
V
F
A
A
G
D
C
T
T
V
---
P
---------
Y
---------
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
T
K
I
----
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
65.06
24%
-56
- C1 -
4YRY
3
?
B:
[48-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
G
C
P
V
E
I
D
I
P
G
F
I
R
K
L
R
D
G
-
K
-
L
E
E
S
Y
R
I
L
K
S
Y
N
N
L
P
A
---
V
C
G
-----
R
V
C
P
---
Q
EVQ
C
E
S
R
C
V
V
G
--
K
MKD
S
E
P
-
V
A
I
G
R
L
E
R
F
V
A
D
-----------------
W
A
A
E
N
L
E
E
D
V
K
P
L
A
G
S
K
K
E
K
---
V
A
V
V
G
S
G
P
A
G
L
T
A
A
A
D
L
A
K
M
G
--
Y
--
H
--
V
D
I
F
---
E
A
F
----------------------
H
K
P
----------
G
G
V
L
V
Y
-----
G
--
I
-
P
-----
E
--------------
F
R
-
L
----
P
K
-----------
R
I
V
E
----
R
---
E
V
S
Y
I
R
K
-
L
G
V
-
N
---
F
HLNTVV-----
G
-
K
-
T
V
K
V
-----
K
E
L
L
S
E
-
Y
D
A
V
F
I
G
T
G
A
G
T
P
K
F
--------
M
-
G
I
P
G
T
--
N
--
L
---
N
G
V
Y
S
---
A
N
E
F
L
T
R
V
N
L
M
K
A
Y
L
F
P
-
E
Y
-
D
---
T
P
-
I
R
V
G
K
K
V
A
V
I
G
A
G
--
N
T
A
M
D
A
A
R
S
A
L
R
-----------------------
L
G
A
E
K
V
Y
-------
I
V
Y
R
R
T
E
R
E
M
P
A
R
R
E
E
Y
H
H
A
L
E
E
G
I
E
F
L
W
L
T
L
P
I
R
Y
-
I
G
D
A
N
G
N
V
E
A
M
E
C
V
R
M
E
L
K
E
A
D
G
S
G
R
------
P
R
P
V
P
I
--
E
G
-
S
-
N
--
F
V
-
L
E
V
-
D
M
V
I
E
A
----------
I
G
-----
Q
-
G
-
P
--
N
-
R
V
L
L
S
E
F
P
G
L
E
L
N
-
E
R
G
Y
I
--------
K
A
-----
D
E
D
T
G
A
T
S
V
K
G
---------------
V
F
A
G
G
D
I
V
T
G
A
A
T
V
I
K
A
M
G
A
---
G
K
-
K
--
A
A
Q
--
F
I
H
S
Y
L
T
G
E
W
N
P
W
Q
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
64.96
16%
-61
* C1 *
3R9U
2
?
A:
[3-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
L
--
D
V
A
I
I
G
G
G
P
A
G
L
S
A
G
L
Y
A
T
R
G
G
--
L
--
K
N
-
V
V
M
F
---
E
K
G
M
P
-
G
G
Q
--
I
T
--
S
S
S
E
I
E
N
Y
P
-
G
--
V
A
Q
-
V
----
M
D
G
I
--------
S
--
F
-
M
-----
A
P
W
--
S
------
E
Q
C
M
R
-
F
-----
G
------------
L
K
H
----
E
---
M
V
G
V
E
Q
I
-
L
K
N
-
S
---
D
G----------
S
-
F
-
T
I
K
L
-----
E
G
G
K
T
E
L
A
K
A
V
I
V
C
T
G
S
-
A
P
K
K
--------
A
-
G
F
K
G
E
--
D
--
E
FFG
K
G
V
S
T
---
C
A
T
C
D
-
G
-------------------
F
-
F
Y
K
N
K
E
V
A
V
L
G
G
G
--
D
T
A
L
E
E
A
L
Y
L
A
N
I
--------------------
C
-
S
---------------------------------------------------------------------------
K
------
I
Y
L
I
H
R
--
R
D
-
E
F
R
--
A
A
-
P
-------
S
T
----------
V
E
-----
K
-
V
K
K
--
N
-
E
K
I
E
L
I
T
S
A
S
V
D
E
-
V
Y
G
D
K
---------
M
-----
G
V
A
G
V
K
V
K
L
-
K
---------------
D
G
S
I
R
D
L
N
V
P
G
I
F
T
F
V
G
L
N
V
---
R
N
-
E
--
I
L
K
--
Q
D
D
S
K
F
L
C
N
------
M
E
E
G
G
Q
V
S
V
D
L
-------------
K
M
Q
T
S
V
A
G
----
L
F
A
A
G
D
L
R
K
D
---
A
---------
P
---------
K
Q
V
I
C
A
A
G
D
G
A
V
A
A
L
S
A
M
A
Y
I
E
S
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
64.73
24%
-52
- C1 -
4YLF
4
?
B:
[48-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
G
C
P
V
E
I
D
I
P
G
F
I
R
K
L
R
D
G
-
K
-
L
E
E
S
Y
R
I
L
K
S
Y
N
N
L
P
A
---
V
C
G
-----
R
V
C
P
---
Q
EVQ
C
E
S
R
C
V
V
G
--
K
MKD
S
E
P
-
V
A
I
G
R
L
E
R
F
V
A
D
-----------------
W
A
A
E
N
L
E
E
DVK
P
L
A
G
S
K
K
E
K
---
V
A
V
V
G
S
G
P
A
G
L
T
A
A
A
D
L
A
K
M
G
--
Y
--
H
--
V
D
I
F
---
E
A
F
----------------------
H
K
P
----------
G
G
V
L
V
Y
-----
G
--
I
-
P
-----
E
--------------
F
R
-
L
----
P
K
-----------
R
I
V
E
----
R
---
E
V
S
Y
I
R
K
-
L
G
V
-
N
---
F
HLN
T
V
V
-----
G
-
K
-
T
V
K
V
-----
K
E
L
L
S
E
-
Y
D
A
V
F
I
G
T
G
A
G
T
P
K
F
--------
M
-
G
I
P
G
T
--
N
--
L
---
N
G
V
Y
S
---
A
N
E
F
L
T
R
V
N
L
M
K
A
Y
L
F
P
-
E
Y
-
D
---
T
P
-
I
R
V
G
K
K
V
A
V
I
G
A
G
--
N
T
A
M
D
A
A
R
S
A
L
R
-----------------------
L
G
A
E
K
V
Y
-------
I
V
Y
R
R
T
E
R
E
M
P
A
R
R
E
E
Y
H
H
A
L
E
E
G
I
E
F
L
W
L
T
L
P
I
R
Y
-
I
G
D
A
N
G
N
V
E
A
M
E
C
V
R
M
E
L
K
E
A
D
G
S
G
R
------
P
R
P
V
P
I
--
E
G
-
S
-
N
--
F
V
-
L
E
V
-
D
M
V
I
E
A
----------
I
G
-----
Q
-
G
-
P
--
N
-
R
V
L
L
S
E
F
P
G
L
E
L
N
-
E
R
G
Y
I
--------
K
A
-----
D
E
D
T
G
A
T
S
V
K
G
---------------
V
F
A
G
G
D
I
V
T
G
A
A
T
V
I
K
A
M
G
A
---
G
K
-
K
--
A
A
Q
--
F
I
H
S
Y
L
T
G
E
W
N
P
W
Q
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
64.70
17%
-66
- C1 -
1O94
3
DHTM_METME
A:
[303-701]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
K
M
I
E
I
V
T
K
G
Y
A
-
D
I
I
G
C
A
R
P
S
I
A
D
P
F
L
P
Q
K
V
E
Q
G
R
YDDI
R
V
C
I
---
G
---
C
N
V
C
I
S
R
W
E
-
I
---
G
G
P
-
P
M
I
---------
C
T
Q
N
A
T
A
G
E
E
Y
R
---
R
G
W
H
P
E
-------
K
F
R
Q
T
K
N
K
D
--
S
V
L
I
V
G
A
G
P
S
G
S
E
A
A
R
V
L
M
E
S
G
--
Y
--
T
--
V
H
L
T
---
D
T
A
E
K
--------------------------------
I
G
G
H
L
N
Q
V
A
A
LP
G
--
L
-
G
E----
W
S
Y
--
H
------
R
D
Y
R
E
T
Q
----
I
T
-----------
K
L
L
K
----
K
-----
N
K
E
---
S
Q
L
-
A
---
L
-----------
G
Q
K
-
P
M
T
A
-----
D
D
V
L
Q
Y
G
A
D
K
V
I
I
A
T
G
A
-
R
W
N
T
DGTNCLTH
D
-
P
I
P
G
A
--
D
AS
L
---
P
D
Q
L
T
---
P
E
Q
V
M
D
G
-------------------
K
-
K
K
I
G
K
R
V
V
I
L
N
A
D
TY
F
M
A
P
S
L
A
E
K
L
A
T
A
--------------------
G
-
H
E
V
T
---------------------------------------------------------------------------------
I
V
S
G
--
V
H
-
L
-
A
N
-
Y
M
-
H
F
T
--
L
E
Y
P
N
----------
M
M
-----
R
-
R
L
H
--
E
-
L
H
V
E
E
L
G
D
H
F
C
S
R
-
I
E
P
G
R
M
E
I
Y
N
IWG
D
G
SKRTY
R
G
P
G
V
S
P
R
D
-
A
---------------
N
T
S
H
R
W
I
E
F
D
S
L
V
L
V
T
G
R
H
S
---
E
C
-
T
--
L
W
N
--
E
----
L
K
A
R
--------------
E
S
-------------
E
W
A
E
N
D
I
K
G
----
I
Y
L
I
G
D
A
E
A
--------------
P
---------
R
L
I
A
D
A
T
F
T
G
H
R
V
A
R
E
I
E
E
A
N
P
Q
I
A
I
----
P
Y
K
R
E
T
I
A
W
G
T
P
H
M
P
G
G
N
F
K
I
E
Y
K
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
62.69
17%
-64
- C1 -
1MO9
2
XECC_XANP2
A:
[38-379]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
D
P
R
E
Y
--
D
A
I
F
I
G
G
G
A
A
G
R
F
G
S
A
Y
L
R
A
M
G
--
G
--
R
--
Q
L
I
V
---
D
R
W
P
F
L
G
G
S
CP
H
N
--
A
C
V
P
H
H
L
F
S
--
D
C
A
A
E
L
M
L
A
R
T
F
S
G
Q
--
Y
-----
W
--
F
-
P
------
D
M
--
T
EKVVG
I
K
E
V
V
D
-
L
----
F
R
A
G
R
N
G
P
H
G
I
M
N
F
Q
S
K
----
E
---
Q
L
N
L
E
Y
I
-
L
N
C
-
P
A
K
V
I
-----------
D
N
H
-
T
V
E
A
------
A
G
K
V
F
K
A
K
N
L
I
L
A
V
G
A
-
G
P
G
T
--------
L
-
D
V
P
G
V
--
N
--
A
---
K
G
V
F
D
---
H
A
T
L
V
E
E
L
D
-------------------
Y
E
P
G
S
T
V
V
V
V
G
G
S
--
K
T
A
V
E
Y
G
C
F
F
N
A
T
G
---------------------
R
R
T
V
M
L
V
-------
R
T
-
E
P
L
K
L
I
---------------------------------------------------
K
D
--------------------
N
--
E
T
--------
R
A
Y
----------
V
L
-----
D
-
R
M
K
--
E
-
Q
G
M
E
I
I
S
G
S
N
V
T
R
-
I
E
E
D
A
--------
N
G
-----
R
V
Q
A
V
V
A
M
T
-
P
----------------
N
G
E
M
R
I
E
T
D
F
V
F
L
G
L
G
E
Q
P
---
R
S
A
E
--
L
A
K
--
I
L
G
--
L
D
L
G
--------
P
K
G
E
V
L
V
N
E
-------------
Y
L
Q
T
S
V
P
N
----
V
Y
A
V
G
D
L
I
G
----
G
---------
P
---------
M
E
M
F
K
A
R
K
S
G
C
Y
A
A
R
N
V
M
G
E
K
I
S
Y
T
P
----
K
N
Y
P
D
F
L
H
T
H
Y
E
V
S
F
L
G
M
G
E
E
E
A
R
A
A
G
H
E
I
V
T
I
K
M
P
P
D
T
E
N
G
L
N
V
A
L
P
A
S
D
R
T
M
L
Y
A
F
G
K
G
T
A
H
M
S
G
F
Q
K
I
V
I
D
A
K
T
R
K
V
L
G
A
H
H
V
G
Y
G
A
K
D
A
F
Q
Y
L
N
V
L
I
K
Q
G
L
T
V
D
E
L
G
D
M
D
E
L
F
L
N
P
T
H
F
I
Q
L
S
R
L
R
A
G
S
K
N
L
V
S
L
---------------------------------------------------------------------------------------------
33
HHSearch
62.16
18%
-64
- C1 -
3KLJ
1
NROR_CLOAB
A:
[8-322]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
T
--
K
I
L
I
L
G
A
G
P
A
G
F
S
A
A
K
A
A
L
G
K
C
--
D
--
D
--
I
T
M
I
---
N
S
E
K
Y
-
L
P
Y
--
Y
R
--
P
-----------
R
L
N
E
-----
I
I
A
K
N
K
S
I
----------------------------
D
D
I
L
I
K
K
----
N
D
-----------
W
Y
E
---------
K
N
N
I
K
V
I
-
T
S
E
-
F
ATS
I
DPN--------
N
-
K
-
L
V
T
L
-----
K
S
G
E
K
I
K
Y
E
K
L
I
I
A
S
G
S
-
I
A
N
K
--------
I
-
K
V
P
H
A
--
D
-------
E
I
F
S
L
YS
Y
D
D
A
L
K
-
I
K
----------------
D
E
-
C
K
N
K
G
K
A
F
I
I
G
G
G
--
I
L
G
I
E
L
A
Q
A
I
I
D
S
--------------------
G
-
T
P
A
S
-
I
G
-------
I
I
L
E
Y
P
L
E
R
Q
--------------------------------------------------
L
D
--------------------
R
--
D
G
--------
G
L
F
----------
L
K
-----
D
-
K
L
D
--
R
-
L
G
I
K
I
Y
T
N
S
N
F
E
E
-
M
----------------------------------------------
G
--
D
L
I
R
S
S
C
V
I
T
A
V
G
V
K
P
---
N
L
-
D
--
F
I
K
--
D
T
E
--
I
A
S
----------
K
R
G
I
L
V
N
D
-------------
H
M
E
T
S
I
K
D
----
I
Y
A
C
G
D
V
A
E
F
YGK
N
---------
P
---------
G
L
I
N
I
A
N
K
Q
G
E
V
A
G
L
N
A
C
G
E
D
---
A
S
----
Y
S
E
I
I
P
S
P
I
L
K
V
S
G
I
S
I
I
S
C
G
D
I
E
N
N
K
P
S
K
V
F
R
S
T
Q
E
D
K
Y
I
V
C
M
L
K
E
N
K
I
D
A
A
A
V
I
G
D
V
S
L
G
T
K
L
K
K
A
I
D
S
S
K
S
F
D
N
I
S
S
L
D
A
I
L
N
N
L
------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
61.89
12%
-15
- C1 -
3K30
3
?
A:
[7-690]
-----------------------------------------------------
V
A
A
P
Y
D
V
L
F
E
P
V
Q
I
G
P
F
T
T
K
N
R
F
Y
Q
V
P
H
C
N
G
M
G
Y
R
D
P
S
A
Q
A
S
M
R
K
I
K
A
E
G
G
W
S
A
V
C
T
E
Q
V
E
I
------
H
A
T
S
D
I
A
P
F
I
E
L
R
I
W
D
D
Q
D
L
P
A
L
K
R
I
A
D
A
I
H
E
G
G
G
L
A
G
I
E
L
A
H
N
G
M
N
A
P
N
Q
L
S
R
E
T
P
L
G
P
----
G
H
L
PVAPDT
I
A
P
I
Q
A
R
A
M
T
K
Q
D
I
D
D
L
R
R
W
H
R
N
A
V
R
R
S
I
E
A
GYD
I
V
Y
V
Y
G
-
A
H
G
Y
S
G
V
H
H
F
L
S
---
K
R
Y
N
Q
R
T
D
E
Y
G
G
S
L
E
N
R
--
M
R
L
L
-
R
E
L
L
E
D
T
L
D
E
C
A
G
R
A
A
V
-----
A
C
R
I
T
V
E
E
E
I
D
G
G
I
--
T
R
E
D
I
E
G
V
L
R
E
L
G
E
L
P
D
L
W
D
F
A
M
G
S
W
E
G
D
SVT
S
R
F
A
P
E
G
R
Q
E
E
F
V
A
G
L
K
K
L
T
T
K
P
V
-
V
G
V
G
R
F
T
S
P
D
A
M
V
R
Q
--
I
K
A
G
I
-
L
-
D
L
I
G
A
A
R
P
S
I
A
D
P
F
L
P
---
N
K
I
R
----
D
G
R
L
---
N
---
L
I
R
E
C
I
G
C
--
N
-------
I
C
V
S
G
D
L
T
M
S
P
I
R
C
T
Q
N
P
S
M
G
E
E
W
R
R
--
G
W
H
P
----
E
---
R
I
R
A
K
E
S
D
A
--
R
V
L
V
V
G
A
G
P
S
G
L
E
A
A
R
A
L
G
V
R
G
--
Y
--
D
--
V
V
L
A
---
E
A
G
R
---
D
L
--
G
G
--
R
V
T
Q
E
S
A
L
P
---------------
G
L
S
A
W
-----
G
--
R
-
V
-----
K
E
Y
--
R
------
E
A
V
L
A
-
E
----
L
P
-----------
N
V
E
I
----
Y
---
R
E
S
-----------------------------
P
M
T
G
-----
D
D
I
V
E
F
G
F
E
H
V
I
T
A
T
G
-----
A
--------
T
-
W
R
T
D
G
--
V
--
A
---
R
F
H
T
T
---
A
L
P
I
A
E
G
M
Q
V
L
G
P
-
D
D
L
-
F
A
-
G
---
R
L
-
P
D
G
K
K
V
V
V
Y
D
D
D
H
--
Y
Y
L
G
G
V
V
A
E
L
L
A
Q
K
-------------------
G
-
Y
E
V
S
I
V
T
PGAQVSS
W
T
N
N
T
F
E
V
N
R
I
Q
R
R
L
I
E
N
G
V
A
R
V
T
D
H
A
V
V
A
V
G
A
G
G
V
-
T
V
R
D
T
Y
A
S
I
E
R
E
L
E
C
D
A
V
V
M
V
T
A
R
L
P
------
R
E
E
L
Y
L
--
D
L
-
V
-
A
--
R
R
-
D
A
G
-
E
I
A
S
V
R
G
I
G
DAWAPGT
I
A
-----
A
-
A
-
V
--
W
-
S
G
R
R
A
A
E
E
F
D
A
V
L
-
P
S
N
D
E
--------
V
P
-----
F
R
R
E
V
T
Q
L
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
61.69
15%
-63
- C1 -
2GQW
7
?
A:
[6-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
A
--
P
V
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
Q
A
G
--
Y
--
Q
G
L
I
T
V
V
---
G
D
E
A
E
-
R
P
Y
--
D
-------------
R
P
P
L
S
K
D
F
----
M
A
H
G
-----------
D
-
A
-----------------
E
K
I
R
L
-------
D
-----------
C
-
K
-----
R
---
A
P
E
V
E
W
L
-
L
G
V
-
T
---
A
QSFDPQ-----
A
-
H
-
T
V
A
L
-----
S
D
G
R
T
L
P
Y
G
T
L
V
L
A
T
G
A
-
A
P
R
A
--------
L
P
T
L
Q
G
A
--
T
------
M
P
V
H
T
---
L
R
T
L
E
D
A
R
R
I
Q
--------------
A
G
-
L
R
P
Q
S
R
L
L
I
V
G
G
G
--
V
I
G
L
E
L
A
A
T
A
R
T
A
--------------------
G
-
V
H
V
S
-
L
V
-------
E
T
Q
P
R
L
M
S
R
A
----------------------------------------------------------------------------
A
-
P
A
T
---
L
A
D
F
----------
V
A
-----
R
-
Y
H
A
--
A
-
Q
G
V
D
L
R
F
E
R
S
V
T
G
-
S
V
D
G
-------------------
V
V
L
L
D
D
------------------
G
--
T
R
I
A
A
D
M
V
V
V
G
I
G
V
L
A
---
N
D
-
A
--
L
A
R
--
A
A
G
--
L
A
C
D
---------
D
G
I
F
-
V
D
A
-------------
Y
G
R
T
T
C
P
D
----
V
Y
A
L
G
D
V
T
R
Q
---
R
---------
N
PLSGRFERI
E
T
W
S
N
A
Q
N
Q
G
I
A
V
A
R
H
L
V
D
P
T
---
A
P
----
G
Y
A
E
L
P
W
Y
W
S
D
Q
G
A
L
R
I
Q
V
A
G
L
A
S
G
D
E
E
I
V
R
G
E
V
S
L
D
A
P
K
F
T
L
I
E
L
Q
K
G
R
I
V
G
A
T
C
V
N
N
A
R
D
F
A
P
L
R
R
L
L
A
V
G
A
K
P
D
R
A
A
L
A
D
P
A
T
D
L
R
K
L
A
A
A
V
-----------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
60.01
14%
-66
- C1 -
3CGB
2
?
A:
[37-353]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
N
Y
V
I
I
G
G
D
A
A
G
M
S
A
A
M
Q
I
V
R
N
D
EN
A
--
N
--
V
V
T
L
---
E
K
G
E
I
-
Y
S
Y
--
A
Q
--
C
G
--
L
P
Y
V
--------------
I
S
G
A
I
A
------------------
S
T
--
E
------
K
L
I
A
R
-
N
----
V
K
-----------
T
F
R
D
--------
K
Y
G
I
D
A
K
-
V
R
H
-
E
---
V
TKVDTE-----
K
-
K
-
I
V
Y
A
E
HTKT
K
D
V
F
E
F
S
Y
D
R
L
L
I
A
T
G
V
-
R
P
V
M
--------
P
-
E
W
E
G
R
--
D
--
L
---
Q
G
V
H
L
---
L
K
T
I
P
D
A
E
R
I
L
K
-------
T
-
L
----
E
-
T
N
K
V
E
D
V
T
I
I
G
G
G
--
A
I
G
L
E
M
A
E
T
F
V
E
L
--------------------
G
-
K
K
V
R
-
M
I
-------
E
R
N
D
H
I
G
T
I
Y
D
-----------------------------------------------------------------------
G
--
D
M
--------
A
E
Y
----------
I
Y
-----
K
-
E
A
D
--
K
-
H
H
I
E
I
L
T
N
E
N
V
K
A
-
F
K
G
N
----------
E
-----
R
V
E
A
V
E
-
T
--------------------
D
K
G
T
Y
K
A
D
L
V
L
V
S
V
G
V
K
P
---
N
T
-
D
--
F
L
E
--
G
T
N
--
I
R
T
N
--------
H
K
G
A
I
E
V
N
A
-------------
Y
M
Q
T
N
V
Q
D
----
V
Y
A
A
G
D
C
A
T
H
---
Y
H
VIKE
I
H
D
H
I
---------
P
I
G
T
T
A
N
K
Q
G
R
L
A
G
L
N
M
L
D
K
R
R
A
F
K
G
----
T
L
G
T
G
I
I
K
F
M
N
L
T
L
A
R
T
G
L
N
E
K
E
A
K
G
L
H
I
P
Y
K
T
V
K
V
D
S
T
N
M
A
G
Y
Y
P
N
A
K
P
L
Y
L
K
L
L
Y
R
S
D
T
K
Q
L
L
G
G
Q
V
I
G
E
E
G
V
D
K
R
I
D
V
I
A
M
A
L
F
N
K
M
S
I
H
D
L
E
D
V
D
L
S
Y
A
P
P
Y
N
S
V
W
D
P
I
Q
Q
A
A
R
R
A
E
---------------------------------------------------------------------------------------------------------------
40
HHSearch
58.72
16%
-54
- C1 -
3IC9
2
?
A:
[5-338]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
N
V
--
D
V
A
I
I
G
T
G
T
A
G
M
G
A
Y
R
A
A
K
K
H
T
--
D
--
K
--
V
V
L
I
---
E
G
G
A
Y
-
G
T
T
--
C
A
RV
G
C
M
P
S
K
L
L
I
-
A
A
A
D
A
S
Y
H
----
A
S
Q
T
D
L
F
-----
G
--
I
-
Q
VD
R
I
S
V
N
G
--
K
------
A
-
V
M
K
-
R
I
Q
T
E
R
D
-----------
R
F
V
G
F
V
V
E
S
V
E
S
F
D
E
Q
D
K
I
R
G
F
A
-
K
---
F
LD---------
E
-
H
-
T
L
Q
V
-----
D
D
H
S
Q
V
I
A
K
R
I
V
I
A
T
G
S
-
R
P
N
Y
--------
P
-
E
F
L
A
A
--
A
--
G
---
S
R
L
L
T
---
N
D
N
L
F
E
L
---------------------
N
D
L
P
K
S
V
A
V
F
G
P
G
--
V
I
G
L
E
L
G
Q
A
L
S
R
L
--------------------
G
-
V
I
V
K
---------------------------------------------------------------------------------
V
F
G
R
--
S
G
-
S
-
V
---
A
-
N
L
Q
D
E
E
M
K
R
Y
----------
A
E
-----
K
-
T
-
F
--
N
-
E
E
F
Y
F
D
A
K
A
R
V
I
S
T
I
E
K
E
----------
D
-----
A
V
E
V
I
Y
F
D
--
K
---------------
S
G
Q
K
T
T
E
S
F
Q
Y
V
L
A
A
T
G
R
K
A
---
N
V
-
D
--
K
L
G
LE
N
T
S
--
I
E
L
D
--------
K
K
N
S
P
L
F
D
E
------------
L
T
L
Q
T
S
V
D
H
----
I
F
V
A
G
D
A
N
N
----
T
---------
L
---------
T
L
L
H
E
A
A
D
D
G
K
V
A
G
T
N
A
G
A
Y
P
V
I
A
Q
G
----
Q
R
R
A
P
L
S
V
V
F
T
E
P
Q
V
A
S
V
G
L
S
L
R
Q
I
E
D
L
Y
A
D
Q
D
A
A
N
Y
V
V
G
Q
V
S
F
E
G
Q
G
R
S
R
V
M
G
K
N
K
G
L
L
N
V
Y
A
D
R
T
S
G
E
F
L
G
A
E
M
F
G
P
A
A
E
H
I
G
H
L
L
A
W
A
R
Q
Q
Q
M
T
V
Q
A
M
L
T
M
P
F
Y
H
P
V
I
E
E
G
L
R
T
A
L
R
D
A
Q
Q
K
L
A
I
E
K
H
D
M
N
E
F
I
M
T
H
--------------------------------------------------------------------------------------------
39
HHSearch
58.35
16%
-64
- C1 -
1GES
1
GSHR_ECOLI
A:
[3-329]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
Y
--
D
Y
I
A
I
G
G
G
S
G
G
I
A
S
I
N
R
A
A
M
Y
G
--
Q
--
K
--
C
A
L
I
---
E
A
K
E
L
-
G
G
T
--
C
V
NV
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
-
A
I
-
H
M
Y
G
P
D
Y
G
F
-----
D
TT
I
N
K
-----
F
N
W
--
E
T
L
I
A
S
R
T
A
Y
I
D
-
R
I
H
T
S
Y
E
-----------
N
V
L
G
--------
K
N
N
V
D
V
I
-
K
G
F
A
R
F
--
V
-----------
D
A
K
-
T
L
E
V
------
N
G
E
T
I
T
A
D
H
I
L
I
A
T
G
G
-
R
P
S
H
--------
P
-
D
I
P
G
V
--
E
-------
Y
G
I
D
---
S
D
G
F
F
A
--------------------
L
-
P
A
L
P
E
R
V
A
V
V
G
A
G
--
Y
I
G
V
E
L
G
G
V
I
N
G
L
--------------------
G
-
A
K
T
H
-
L
F
-------
E
M
F
D
A
P
L
P
S
F
D
-----------------------------------------------------------------------
P
--
M
I
--------
S
E
T
----------
L
V
-----
E
-
V
M
N
--
A
-
E
G
P
Q
L
H
T
N
A
I
P
K
A
-
V
V
K
N
T
--------
D
G
-----
S
L
-
T
L
E
L
E
D
------------------
G
--
R
S
E
T
V
D
C
L
I
W
A
I
G
R
E
P
---
A
N
-
D
--
N
I
N
--
L
E
A
A
G
V
K
T
N
--------
E
K
G
Y
I
V
V
D
K
-------------
Y
Q
N
T
N
I
E
G
----
I
Y
A
V
G
D
N
T
G
----
A
---------
V
---------
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
F
N
N
K
P
D
E
H
L
----
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
Q
V
K
V
Y
K
S
S
F
T
A
M
Y
T
A
V
T
T
H
R
Q
P
C
R
M
K
L
V
C
V
G
S
E
E
K
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
T
A
A
E
E
F
V
T
M
R
--------------------------------------------------------------------------------------------------------------------