@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0061: (2015-11-28 )
MNEFKSIRNIAIIAHVDHGKTTLLDNMLKQSGTFRENQEVQERVMDSGNQERERGITILAKCTSIMWGDEKINIIDTPGHADFGGEVERVLCMVDGVLLLVDAAEGPMPQTKFVLSKALKADLKSIVIINKVDRPDSRIDEVLNEIYELFFNLDATNEQLDFPVLYASGRNGWCIKELSDKRKDLSPLFSTVIDYIKPANYDRNAPFAMLVTLLESDKFLGRILTGKIYQGIAKVNSDLKVLDLDGKVIKRGRLTKLLSFSGLKRIPVEQAVAGDIIAIAGLEKASVSATIVAPEVTTAISSTPVDPPTMAITLSVNDSPFAGQEGTKLTSAIIKDRLYAEAEINVAITVTPTPNDEAFEVGGRGELQLGVLIENMRREGFELSVSRPRVLFKEEGGKKLEPIEEVVIDVDDEYSGIIMKKLSFRKGEVTDMRPSGSGRTRLIFLVPSRGLIGYQGEFLTDSRGTGIINRLFHSYAPYKGPISRRRNGVLISTDKGEAVAYAIFNLQDRGIMFIKPQDRVYCGMVVGQHSRDNDLEINVLKGKQLTNVRAAGSDEAIKLTPPKTMTLEDMIAYIDDDELVEVTPKSIRLRKKFLDPNERRRAEKAKNKE
Atome Classification :
(20 SA)
.........10........20........30.......------.----40........50........60......-----------------------.-----------------------.70........80........90........100....--...110.......120-.-......130......----.-------140.......150--------------------------------------------.---------------------------------------------------------------------------.--------------------------------------------------------.---------------.----------------------------------------------.--------------------------------------------.---------------------------------.-----------------------..160.......170.......------------------180-----------------------------..-------------------------------------------------------------------------------...-....190...------------------....-----200--------------------------.---------.......210....---.--.----.---220.--------.......230.......240....-----.------.---------.250.......260-........270.......----280-.----.--.--.-.....290...---..--..300...-.....310.......320.......330.......340.......350.......360.......370.......--380...-----....390-.-...-.-------------------------------------------------------------------------------------------------------------------------------------------------------------.-----------------------------------------------------------------------------------------------------------...400---------------.........410.........420.....---..430....-...440.......450-.......460.......470.......-480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
N
E
F
K
S
IR
N
I
A
I
I
A
H
VDHG
K
T
T
L
L
D
N
M
L
K
QSGTFRE
N
Q
------
E
----
V
Q
E
R
V
M
DSGN
Q
E
R
E
R
G
I
T
I
L
A
K
C
T
S
IMW-----------------------G-----------------------D
E
K
I
N
I
I
DTPGHADFG
G
E
V
E
R
V
L
C
M
VD
G
V
L
L
L
V
DAAEG--PMP
Q
T
K
F
V
L
S
K
A
L
K
A
D
-
L
-
K
S
I
V
I
I
NKVDRP
D
S
R
----
I
-------
D
E
V
L
N
E
I
Y
E
L
F
----------------------------------------------F---------------------------------------------------------------------------N--------------------------------------------------------L---------------D----------------------------------------------A--------------------------------------------T---------------------------------N-----------------------EQLD
F
P
V
L
Y
ASGRNGW
C
I
K
E
L
S
------------------
D
-------------------------------KR-------------------------------------------------------------------------------K
D
L
-
S
P
L
F
S
T
V
I
D
Y
------------------IKPA-----NY---------------------------D---------RNA
P
F
A
M
L
V
T
L
L
ES---
D
--
K
----
F
---
L
-
G
R
--------
I
L
T
G
K
I
Y
Q
G
I
A
K
VNSD
L
K
V
L
DLDG-----
K
------
V
---------IKRG
R
L
T
K
L
L
S
FS--GLKRI
P
V
E
Q
AVAG
D
I
I
A
I
----A---G----L--E--K-AS
V
S
A
T
I
VAP
E
---
V
T
--TAI-SSTP-VDPP
T
M
A
I
T
L
SVNDSPFAGQEG
T
K
L
T
S
A
I
I
K
D
RLYA
E
A
E
I
N
V
A
I
T
V
TPTPNDE
A
F
EVGGRG
E
L
Q
L
G
V
L
I
E
N
M
R
RE--G
F
E
L
SV-----SR
P
R
V
---
L
-
F
KE-E-------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------------------------------------------------------------------------------------------------------GKKL-----------------E
P
I
E
E
V
V
I
DV--DDEYS
G
I
I
M
K
K
LSFRKG---EV
T
D
MRPSG-SG
R
T
R
L
I
F
L
VPSRGLI-GYQ
G
E
F
LTDSRG
T
G
I
I
N
R
L
F
H
SYAPYK-GPISRRRN
G
V
L
I
STDKG
E
A
V
A
Y
A
I
F
NLQDR
G
I
M
F
IKPQD
R
V
Y
C
G
M
V
VGQHSRDN
D
L
E
I
N
V
LKGKQL
T
N
V
RAAGSD
E
A
I
KLTPPKTM
T
L
E
D
M
I
A
YIDDDE
L
V
EVT
P
K
S
I
R
L
R
K
K
FL
D
P
N
E
R
R
R
A
E
KAKNKE
23
PsiBlast_CBE
94.70
52%
-97
- C1 -
4ZCI
2
?
B:
[37-634]
----
E
K
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
Q
Q
S
G
----------------------------------
T
I
L
A
K
N
T
A
I
K
W
-----------------------
N
-----------------------
D
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
--
P
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
-
L
-
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
----
P
-------
D
W
V
V
D
Q
V
F
D
L
F
----------------------------------------------
V
---------------------------------------------------------------------------
N
--------------------------------------------------------
L
---------------
D
----------------------------------------------
A
--------------------------------------------
T
---------------------------------
D
-----------------------
E
Q
L
D
F
P
I
V
Y
A
S
A
L
N
G
I
A
G
L
D
H
E
------------------
D
-------------------------------
M
A
-------------------------------------------------------------------------------
E
D
M
-
T
P
L
Y
Q
A
I
V
D
H
------------------
V
P
A
P
-----
D
V
---------------------------
D
---------
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
---
N
--
S
----
Y
---
V
-
G
V
--------
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
-----
K
------
T
----------
R
N
A
K
V
G
K
V
L
G
H
L
--
G
L
E
R
I
E
T
D
L
A
E
A
G
D
I
V
A
I
----
T
---
G
----
L
--
G
--
E
-
L
N
I
S
D
T
V
C
D
T
Q
---
N
V
--
E
A
L
-
P
A
L
S
-
V
D
E
P
T
V
S
M
F
F
C
V
N
T
S
P
F
C
G
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
E
T
E
D
A
D
A
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
F
E
L
A
V
-----
S
R
P
K
V
---
I
-
F
R
E
-
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----------------------------------------------------------------------------------------------------------
G
R
K
Q
-----------------
E
P
Y
E
N
V
T
L
D
V
--
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
---
D
L
K
N
M
N
P
D
G
-
K
G
R
V
R
L
D
Y
V
I
P
S
R
G
L
I
-
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
N
G
Q
G
K
A
V
A
F
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
I
H
S
R
S
N
D
L
T
V
N
C
L
T
----------------
V
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
A
N
------
4
PsiBlast_PDB
94.61
52%
-94
- C1 -
4ZCI
2
?
A:
[37-634]
----
E
K
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
Q
Q
S
G
----------------------------------
T
I
L
A
K
N
T
A
I
K
W
-----------------------
N
-----------------------
D
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
--
P
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
-
L
-
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
----
P
-------
D
W
V
V
D
Q
V
F
D
L
F
----------------------------------------------
V
---------------------------------------------------------------------------
N
--------------------------------------------------------
L
---------------
D
----------------------------------------------
A
--------------------------------------------
T
---------------------------------
D
-----------------------
E
Q
L
D
F
P
I
V
Y
A
S
A
L
N
G
I
A
G
L
D
H
E
------------------
D
-------------------------------
M
A
-------------------------------------------------------------------------------
E
D
M
-
T
P
L
Y
Q
A
I
V
D
H
------------------
V
P
A
P
-----
D
V
---------------------------
D
---------
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
---
N
--
S
----
Y
---
V
-
G
V
--------
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
-----
K
------
T
----------
R
N
A
K
V
G
K
V
L
G
H
L
--
G
L
E
R
I
E
T
D
L
A
E
A
G
D
I
V
A
I
----
T
---
G
----
L
--
G
--
E
-
L
N
I
S
D
T
V
C
D
T
Q
---
N
V
--
E
A
L
-
P
A
L
S
-
V
D
E
P
T
V
S
M
F
F
C
V
N
T
S
P
F
C
G
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
E
T
E
D
A
D
A
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
F
E
L
A
V
-----
S
R
P
K
V
---
I
-
F
R
E
-
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----------------------------------------------------------------------------------------------------------
G
R
K
Q
-----------------
E
P
Y
E
N
V
T
L
D
V
--
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
---
D
L
K
N
M
N
P
D
G
-
K
G
R
V
R
L
D
Y
V
I
P
S
R
G
L
I
-
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
N
G
Q
G
K
A
V
A
F
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
I
H
S
R
S
N
D
L
T
V
N
C
L
T
----------------
V
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
A
N
------
21
PsiBlast_CBE
92.27
52%
-93
- C1 -
4ZCM
4
?
B:
[36-635]
---
I
E
K
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
Q
Q
S
G
----------------------------------
T
I
L
A
K
N
T
A
I
K
W
-----------------------
N
-----------------------
D
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
--
P
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
-
L
-
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
----
P
-------
D
W
V
V
D
Q
V
F
D
L
F
----------------------------------------------
V
---------------------------------------------------------------------------
N
--------------------------------------------------------
L
---------------
D
----------------------------------------------
A
--------------------------------------------
T
---------------------------------
D
-----------------------
E
Q
L
D
F
P
I
V
Y
A
S
A
L
N
G
I
A
G
L
D
H
E
------------------
D
-------------------------------
M
A
-------------------------------------------------------------------------------
E
D
M
-
T
P
L
Y
Q
A
I
V
D
H
------------------
V
P
A
P
-----
D
V
---------------------------
D
---------
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
---
N
--
S
----
Y
---
V
-
G
V
--------
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
-----
K
------
T
----------
R
N
A
K
V
G
K
V
L
G
H
L
--
G
L
E
R
I
E
T
D
L
A
E
A
G
D
I
V
A
I
----
T
---
G
----
L
--
G
--
E
-
L
N
I
S
D
T
V
C
D
T
Q
---
N
V
--
E
A
L
-
P
A
L
S
-
V
D
E
P
T
V
S
M
F
F
C
V
N
T
S
P
F
C
G
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
E
T
E
D
A
D
A
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
F
E
L
A
V
-----
S
R
P
K
V
---
I
-
F
R
E
-
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----------------------------------------------------------------------------------------------------------
G
R
K
Q
-----------------
E
P
Y
E
N
V
T
L
D
V
--
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
---
D
L
K
N
M
N
P
D
G
-
K
G
R
V
R
L
D
Y
V
I
P
S
R
G
L
I
-
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
N
G
Q
G
K
A
V
A
F
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
I
H
S
R
S
N
D
L
T
V
N
C
L
T
----------------
V
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
A
N
------
5
PsiBlast_PDB
91.84
52%
-96
- C1 -
4ZCL
3
?
A:
[37-634]
----
E
K
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
Q
Q
S
G
----------------------------------
T
I
L
A
K
N
T
A
I
K
W
-----------------------
N
-----------------------
D
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
--
P
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
-
L
-
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
----
P
-------
D
W
V
V
D
Q
V
F
D
L
F
----------------------------------------------
V
---------------------------------------------------------------------------
N
--------------------------------------------------------
L
---------------
D
----------------------------------------------
A
--------------------------------------------
T
---------------------------------
D
-----------------------
E
Q
L
D
F
P
I
V
Y
A
S
A
L
N
G
I
A
G
L
D
H
E
------------------
D
-------------------------------
M
A
-------------------------------------------------------------------------------
E
D
M
-
T
P
L
Y
Q
A
I
V
D
H
------------------
V
P
A
P
-----
D
V
---------------------------
D
---------
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
---
N
--
S
----
Y
---
V
-
G
V
--------
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
-----
K
------
T
----------
R
N
A
K
V
G
K
V
L
G
H
L
--
G
L
E
R
I
E
T
D
L
A
E
A
G
D
I
V
A
I
----
T
---
G
----
L
--
G
--
E
-
L
N
I
S
D
T
V
C
D
T
Q
---
N
V
--
E
A
L
-
P
A
L
S
-
V
D
E
P
T
V
S
M
F
F
C
V
N
T
S
P
F
C
G
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
E
T
E
D
A
D
A
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
F
E
L
A
V
-----
S
R
P
K
V
---
I
-
F
R
E
-
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----------------------------------------------------------------------------------------------------------
G
R
K
Q
-----------------
E
P
Y
E
N
V
T
L
D
V
--
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
---
D
L
K
N
M
N
P
D
G
-
K
G
R
V
R
L
D
Y
V
I
P
S
R
G
L
I
-
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
N
G
Q
G
K
A
V
A
F
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
I
H
S
R
S
N
D
L
T
V
N
C
L
T
----------------
V
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
A
N
------
22
PsiBlast_CBE
91.57
52%
-93
- C1 -
4ZCL
3
?
B:
[37-634]
----
E
K
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
Q
Q
S
G
----------------------------------
T
I
L
A
K
N
T
A
I
K
W
-----------------------
N
-----------------------
D
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
--
P
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
-
L
-
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
----
P
-------
D
W
V
V
D
Q
V
F
D
L
F
----------------------------------------------
V
---------------------------------------------------------------------------
N
--------------------------------------------------------
L
---------------
D
----------------------------------------------
A
--------------------------------------------
T
---------------------------------
D
-----------------------
E
Q
L
D
F
P
I
V
Y
A
S
A
L
N
G
I
A
G
L
D
H
E
------------------
D
-------------------------------
M
A
-------------------------------------------------------------------------------
E
D
M
-
T
P
L
Y
Q
A
I
V
D
H
------------------
V
P
A
P
-----
D
V
---------------------------
D
---------
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
---
N
--
S
----
Y
---
V
-
G
V
--------
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
-----
K
------
T
----------
R
N
A
K
V
G
K
V
L
G
H
L
--
G
L
E
R
I
E
T
D
L
A
E
A
G
D
I
V
A
I
----
T
---
G
----
L
--
G
--
E
-
L
N
I
S
D
T
V
C
D
T
Q
---
N
V
--
E
A
L
-
P
A
L
S
-
V
D
E
P
T
V
S
M
F
F
C
V
N
T
S
P
F
C
G
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
E
T
E
D
A
D
A
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
F
E
L
A
V
-----
S
R
P
K
V
---
I
-
F
R
E
-
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----------------------------------------------------------------------------------------------------------
G
R
K
Q
-----------------
E
P
Y
E
N
V
T
L
D
V
--
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
---
D
L
K
N
M
N
P
D
G
-
K
G
R
V
R
L
D
Y
V
I
P
S
R
G
L
I
-
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
N
G
Q
G
K
A
V
A
F
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
I
H
S
R
S
N
D
L
T
V
N
C
L
T
----------------
V
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
A
N
------
1
PsiBlast_PDB
91.19
52%
-93
- C1 -
4ZCM
4
?
A:
[36-635]
---
I
E
K
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
Q
Q
S
G
----------------------------------
T
I
L
A
K
N
T
A
I
K
W
-----------------------
N
-----------------------
D
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
--
P
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
-
L
-
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
----
P
-------
D
W
V
V
D
Q
V
F
D
L
F
----------------------------------------------
V
---------------------------------------------------------------------------
N
--------------------------------------------------------
L
---------------
D
----------------------------------------------
A
--------------------------------------------
T
---------------------------------
D
-----------------------
E
Q
L
D
F
P
I
V
Y
A
S
A
L
N
G
I
A
G
L
D
H
E
------------------
D
-------------------------------
M
A
-------------------------------------------------------------------------------
E
D
M
-
T
P
L
Y
Q
A
I
V
D
H
------------------
V
P
A
P
-----
D
V
---------------------------
D
---------
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
---
N
--
S
----
Y
---
V
-
G
V
--------
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
-----
K
------
T
----------
R
N
A
K
V
G
K
V
L
G
H
L
--
G
L
E
R
I
E
T
D
L
A
E
A
G
D
I
V
A
I
----
T
---
G
----
L
--
G
--
E
-
L
N
I
S
D
T
V
C
D
T
Q
---
N
V
--
E
A
L
-
P
A
L
S
-
V
D
E
P
T
V
S
M
F
F
C
V
N
T
S
P
F
C
G
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
E
T
E
D
A
D
A
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
F
E
L
A
V
-----
S
R
P
K
V
---
I
-
F
R
E
-
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----------------------------------------------------------------------------------------------------------
G
R
K
Q
-----------------
E
P
Y
E
N
V
T
L
D
V
--
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
---
D
L
K
N
M
N
P
D
G
-
K
G
R
V
R
L
D
Y
V
I
P
S
R
G
L
I
-
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
N
G
Q
G
K
A
V
A
F
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
I
H
S
R
S
N
D
L
T
V
N
C
L
T
----------------
V
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
A
N
------
3
PsiBlast_PDB
85.22
52%
-80
- C1 -
5A9X
1
?
A:
[3-602]
----
E
K
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
Q
Q
S
G
-----------------------------
K
E
R
G
I
T
I
L
A
K
N
T
A
--------------------------------------------------
D
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
--
P
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
-
L
-
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
----
P
-------
D
W
V
V
D
Q
V
F
D
L
F
----------------------------------------------
V
---------------------------------------------------------------------------
N
--------------------------------------------------------
L
---------------
D
----------------------------------------------
A
--------------------------------------------
T
---------------------------------
D
-----------------------
E
Q
L
D
F
P
I
V
Y
A
S
A
L
N
---
G
L
D
H
E
------------------
D
-------------------------------
M
A
-------------------------------------------------------------------------------
E
D
M
-
T
P
L
Y
Q
A
I
V
D
H
------------------
V
P
A
P
-----
D
V
---------------------------
D
---------
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
---
N
--
S
----
Y
---
V
-
G
V
--------
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
-----
K
------
T
----------
R
N
A
K
V
G
K
V
L
G
H
L
--
G
L
E
R
I
E
T
D
L
A
E
A
G
D
I
V
A
I
----
T
--------------
E
-
L
N
I
S
D
T
V
C
D
T
Q
---
N
V
--
E
A
L
-
P
A
L
S
-
V
D
E
P
T
V
S
M
F
F
C
V
N
T
S
P
F
C
G
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
E
T
E
D
A
D
A
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
F
E
L
A
V
-----
S
R
P
K
V
---
I
-
F
R
E
-
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----------------------------------------------------------------------------------------------------------
G
R
K
Q
-----------------
E
P
Y
E
N
V
T
L
D
V
--
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
---
D
L
K
N
M
N
P
D
G
-
K
G
R
V
R
L
D
Y
V
I
P
S
R
G
L
I
-
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
N
G
Q
G
K
A
V
A
F
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
I
H
S
R
S
N
D
L
T
V
N
C
L
T
-----------------
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
A
N
R
-----
2
PsiBlast_PDB
82.82
52%
-81
- C1 -
5A9W
1
?
A:
[3-603]
----
E
K
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
Q
Q
S
G
T
--------------------------
L
E
K
E
R
G
I
T
I
L
A
K
N
T
A
--------------------------
N
-----------------------
D
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
--
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
--
P
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
-
L
-
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
----
P
-------
D
W
V
V
D
Q
V
F
D
L
F
----------------------------------------------
V
---------------------------------------------------------------------------
N
--------------------------------------------------------
L
---------------
D
----------------------------------------------
A
--------------------------------------------
T
---------------------------------
D
-----------------------
E
Q
L
D
F
P
I
V
Y
A
S
A
L
N
---
G
L
D
H
E
------------------
D
-------------------------------
M
A
-------------------------------------------------------------------------------
E
D
M
-
T
P
L
Y
Q
A
I
V
D
H
------------------
V
P
A
P
-----
D
V
---------------------------
D
---------
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
---
N
--
S
----
Y
---
V
-
G
V
--------
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
-----
K
------
T
----------
R
N
A
K
V
G
K
V
L
G
H
L
--
G
L
E
R
I
E
T
D
L
A
E
A
G
D
I
V
A
I
----
T
--------------
E
-
L
N
I
S
D
T
V
C
D
T
Q
---
N
V
--
E
A
L
-
P
A
L
S
-
V
D
E
P
T
V
S
M
F
F
C
V
N
T
S
P
F
C
G
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
E
T
E
D
A
D
A
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
F
E
L
A
V
-----
S
R
P
K
V
---
I
-
F
R
E
-
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----------------------------------------------------------------------------------------------------------
G
R
K
Q
-----------------
E
P
Y
E
N
V
T
L
D
V
--
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
---
D
L
K
N
M
N
P
D
G
-
K
G
R
V
R
L
D
Y
V
I
P
S
R
G
L
I
-
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
N
G
Q
G
K
A
V
A
F
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
I
H
S
R
S
N
D
L
T
V
N
C
L
T
G
K
K
L
T
N
----------
V
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
A
N
R
A
P
---
53
HHSearch
69.39
28%
-82
* C1 *
2XEX
2
EFG_STAAU
A:
[6-684]
--
S
L
E
K
T
R
N
I
G
I
M
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
H
---------------------------------
T
S
A
A
T
T
A
A
W
-----------------------
E
-----------------------
G
H
R
V
N
I
I
D
T
P
G
H
V
D
F
T
V
E
V
E
R
S
L
R
V
L
D
G
A
V
T
V
L
D
A
Q
S
G
--
V
E
P
Q
T
E
T
V
W
R
Q
A
T
T
Y
G
-
V
-
P
R
I
V
F
V
N
K
M
D
K
L
G
A
N
----
F
-------
E
Y
S
V
S
T
L
H
D
R
L
----------------------------------------------
Q
ANAAPI
Q
L
P
I
G
AEDEFEAIIDLVEM
K
C
F
K
Y
TNDLGTE
I
E
E
I
E
IPEDH
L
D
R
A
E
E
A
R
A
S
L
I
E
A
V
A
E
T
S
D
E
L
M
E
K
Y
L
G
D
--------------------------------------------------------
E
---------------
E
----------------------------------------------
I
--------------------------------------------
S
V
S
E
L
K
E
A
I
R
Q
A
T
---------------------
T
-----------------------
N
V
E
F
Y
P
V
L
C
G
T
A
F
K
N
------------------------------------------------------------------------------------------------------------------------------------------
K
G
V
-
Q
L
M
L
D
A
V
I
D
Y
------------------
L
P
S
P
-----
L
D
V
K
P
I
I
G
H
R
ASNPE
E
E
V
I
A
K
A-------
D
---------
D
S
A
E
F
A
A
L
A
F
K
V
M
T
---
D
--
P
----
Y
---
V
-
G
K
--------
L
T
F
F
R
V
Y
S
G
T
M
T
S
G
S
Y
V
K
N
S
T
K
G
-----------------------
K
R
E
R
-
V
G
R
L
L
Q
M
H
--
A
N
S
R
Q
E
I
D
T
V
Y
S
G
D
I
A
A
A
----
V
---
G
----
L
--
K
--
D
-
T
G
T
G
D
T
L
C
G
E
K
---
N
D
--
I
I
L
-
E
S
M
E
-
F
P
E
P
V
I
H
L
S
V
E
P
K
S
---------
K
A
D
Q
D
K
M
T
Q
A
L
V
K
L
Q
E
E
D
P
T
F
H
A
H
T
---
T
G
Q
V
I
I
G
G
M
G
E
L
H
L
D
I
L
V
D
R
M
K
K
E
F-
N
V
E
C
N
V
-----
G
A
P
M
V
---
S
-
Y
R
E
T
F
K
S
S
A
Q
V
Q
G
K
F
S
R
QSGG
R
G
Q
Y
G
D
V
H
I
E
F
T
P
N
E
TGA
G
F
E
F
E
N
AIVGGVVPREY
I
P
S
V
E
A
G
L
K
D
A
M
E
N
GVLAG
Y
P
L
I
D
V
K
A
K
L
Y
D
G
S
Y
H
DVDSS
E
M
A
F
K
I
A
A
S
L
A
L
K
E
A
A
K
K
C-----------------------------------------------
D
-----------------------------------------------------------------------------------------------------------
P
V
I
L
-----------------
E
P
M
M
K
V
T
I
E
M
--
P
E
E
Y
M
G
D
I
M
G
D
V
T
S
R
R
G
---
R
V
D
G
M
E
P
R
G
--
N
A
Q
V
V
N
A
Y
V
P
L
S
E
M
F
-
G
Y
A
T
S
L
R
S
N
T
Q
G
R
G
T
Y
T
M
Y
F
D
H
Y
A
E
V
P
-
K
S
I
A
E
D
I
I
K
K
N
K
G
E
--------------------------------------------------------------------------------------------------------------------
56
HHSearch
66.12
22%
-73
- C1 -
2DY1
2
?
A:
[6-653]
---
G
A
M
I
R
T
V
A
L
V
G
H
A
G
S
G
K
T
T
L
T
E
A
L
L
Y
K
T
G
A
K
E
R
R
G
R
V----
E
----
E
G
T
T
T
T
D
Y
T
P
E
A
K
L
H
R
T
T
V
R
T
G
V
A
P
L
L
F
-----------------------
R
-----------------------
G
H
R
V
F
L
L
D
A
P
G
Y
G
D
F
V
G
E
I
R
G
A
L
E
A
A
D
A
A
L
V
A
V
S
A
E
A
G
--
V
Q
V
G
T
E
R
A
W
T
V
A
E
R
L
G
-
L
-
P
R
M
V
V
V
T
K
L
D
K
G
G
D
-----
Y
-------
Y
A
L
L
E
D
L
R
S
T
L
----------------------------------------------
G
---------------------------------------------------------------------------
P
ILPI
D
L
P
L
Y
E
GGKWVGLIDVFHG
K
A
Y
R
Y
E
NG
E
E
R
E
A
E
VPPEE
R
E
R
V
Q
R
F
R
Q
E
V
L
E
A
I
V
E
T
D
E
G
L
L
E
K
Y
L
E
G
E
E
----------------------------------------------
V
--------------------------------------------
T
---------------------------------
G
E
A
L
E
K
A
F
H
E
A
V
R
-----------
R
G
L
L
Y
P
V
A
L
A
S
G
E
R
E
------------------------------------------------------------------------------------------------------------------------------------------
I
G
V
-
L
P
L
L
E
L
I
L
E
A
------------------
L
P
S
P
-----
T
E
R--------------------------
F
---------
G
D
G
P
P
L
A
K
V
F
K
V
Q
V
---
D
--
P
----
F
---
M
-
G
Q
--------
V
A
Y
L
R
L
Y
R
G
R
L
K
P
G
D
S
L
Q
S
E
A
G
-------------------------
Q
V
R
-
L
P
H
L
Y
V
P
M
--
G
K
D
L
L
E
V
E
E
A
E
A
G
F
V
L
G
V
----
P
---
K
----
A
--
E
--
G
-
L
H
R
G
M
V
L
W
Q
G
E
---
K
P
ES
E
E
V
-
P
F
A
R
-
L
P
D
P
N
V
P
V
A
L
H
P
K
---------
G
R
T
D
E
A
R
L
G
E
A
L
R
K
L
L
E
E
D
P
S
L
K
L
E
R
Q
E
E
T
G
E
L
L
L
W
G
H
G
E
L
H
L
A
T
A
K
E
R
L
Q
D
Y
--
G
V
E
V
E
F
-----
S
V
P
K
V
---
P
-
Y
R
E
T
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
V
A
E
G
Q
G
K
Y
K
K
Q
T
GG
H
G
Q
Y
G
D
V
W
L
R
L
E
P
A
S
E
Y
G
F
E
W
RITGGVIPSKY
Q
E
A
I
E
E
G
I
K
E
A
A
KKGVLAGFPVMG
F
K
A
I
VY
N
G
S
Y
H
EVDSS
D
L
A
F
Q
I
A
A
S
L
A
F
K
K
V
M
A
E
AH
P
V
L
L
-----------------
E
P
I
Y
R
L
K
V
L
A
--
P
Q
E
R
V
G
D
V
L
S
D
L
Q
A
R
R
G
---
R
I
L
G
M
E
Q
E
G
--
A
L
S
V
V
H
A
E
V
P
L
A
E
V
L
-
E
Y
Y
K
A
L
P
G
L
T
G
G
A
G
A
Y
T
L
E
F
S
H
Y
A
E
V
P
-
P
H
L
A
Q
R
I
V
Q
E
R
A
Q
E
G
-------------------------------------------------------------------------------------------------------------------
58
HHSearch
61.80
23%
-74
- C1 -
3JB9
-
?
B:
[137-925]
--
G
T
D
D
V
R
S
F
I
V
A
G
H
L
H
H
G
K
S
A
L
L
D
L
L
V
Y
Y
T
H
P
D
T
K
P
P
K-----
R
----
R
S
L
R
Y
T
D
T
H
Y
L
E
R
E
R
V
M
S
I
K
S
T
P
L
T
L
A
V
-----------------------
S
D
MK
G
K
------------------
T
F
A
F
Q
C
I
D
T
P
G
H
V
D
F
V
D
E
V
A
A
P
M
A
I
S
D
G
V
V
L
V
V
D
V
I
E
G
--
V
M
I
N
T
T
R
I
I
K
H
A
I
L
H
D
-
M
-
P
I
V
L
V
L
N
K
V
D
R
L
I
L
E
LRLP
P
N
D
A
Y
H
K
L
R
H
V
I
D
E
V
N
D
N
I
----------------------------------------------
C
---------------------------------------------------------------------------
Q
--------------------------------------------------------
I
---------------
S
----------------------------------------------
K
--------------------------------------------
D
---------------------------------
L
K
Y
R
V
-------------------
S
P
E
L
G
N
V
C
F
A
S
C
D
L
G
Y
C
F
T
L
S
S
F
A
K
L
Y
I
D
R
H
GGID
V
D
L
F
S
K
R
------------------------------
L
W
GD
I
Y
F
D
SKTRKFAKQSLDGSGVR
S
F
V
H
F
I
L
E
P
L
Y
K
L
H
T
L
T
I
S
DE
A
E
K
L
K
K
H
L
S
S
F
QIYLK
P
K
D
Y
L
LDP
K
P
L
L
Q
L
I
C
A
S
F
F
G
F
P
V
G
F
V
N
A
V
T
R
H
------------------
I
P
S
P
-----
R
E
N
A
A
R
K
A
S
Q
S
YIGPINS
S
I
G
K
A
I
L
E
MSR
E
---------
E
S
A
P
L
V
M
H
V
T
K
L
Y
N
---
T
--
V
----
D
---
A
N
N
F
--------
Y
A
F
A
R
V
Y
S
G
Q
V
K
K
G
Q
K
V
K
V
L
G
E
N
Y
-----
S
LEDEED
M
---------
V
V
A
H
-
I
A
E
I
C
V
P
C
--
A
R
Y
R
L
H
V
D
G
A
V
A
G
M
L
V
L
L
----
G
---
G
----
V
--
D
--
N
S
I
S
K
T
A
T
I
V
S
D
N
LK
D
D
P
--
Y
I
F
-
R
P
I
A
H
M
S
E
S
V
F
K
V
A
V
E
P
H
N
---------
P
S
E
L
P
K
L
L
D
G
L
R
K
T
N
K
S
Y
P
L
S
I
T
K
-
V
E
E
S
G
E
H
T
I
F
G
T
G
E
M
Y
M
D
C
L
L
Y
D
L
R
T
L
YS
E
I
E
I
R
V
-----
S
D
P
V
A
---
R
-
F
C
E
T
A
V
D
TSS
I
K
C
F
S
D
T
PNKK
N
R
I
T
M
V
V
E
P
L
E
K
G
I
S
N
D
I
E
N
GKVNINWP
Q
K
R
I
S
E
F
F
Q
K
NYDWD
L
L
A
S
R
S
IWAFGPDDRGT
N
I
L
R
D
D
T
L
S
T
D
V
D
K
N
V
L
N
S
V
K
E
Y
I
K
Q
G
F
Q
W
G
T
REGPLCD
E
T
I
R
N
V
N
F
R
L
M
D
V
V
L
A
P
E
QIYRGGGQI
I
P
T
A
R
R
V
C
Y
S
S
F
L
T
A
S
-----------------------------------------------------------------------------------------------------------
P
R
L
M
-----------------
E
P
V
Y
M
V
E
V
H
A
--
P
A
D
S
L
P
I
I
Y
D
L
L
T
R
R
R
G
---
H
V
L
Q
D
I
P
R
P
G
S
P
L
Y
L
V
R
A
L
I
P
V
I
D
S
C
-
G
F
E
T
D
L
R
V
H
T
Q
G
Q
A
M
C
Q
M
V
F
D
H
W
Q
V
V
P
-
G
D
P
L
D
K
S
I
K
P
K
P
L
E
P
A
R
G
S
D
L
A
R
D
F
L
I
K
T
R
R
R
K
G
L
V
E
D
V
S
T
T
R
Y
F
D
Q
E
M
---------------------------------------------------------------------------------
6
PsiBlast_PDB
57.20
53%
-63
- C1 -
4ZCK
2
?
A:
[35-332]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
S
M
F
F
C
V
N
T
S
P
F
C
G
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
E
T
E
D
A
D
A
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
F
E
L
A
V
-----
S
R
P
K
V
---
I
-
F
R
E
-
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----------------------------------------------------------------------------------------------------------
G
R
K
Q
-----------------
E
P
Y
E
N
V
T
L
D
V
--
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
---
D
L
K
N
M
N
P
D
G
-
K
G
R
V
R
L
D
Y
V
I
P
S
R
G
L
I
-
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
N
G
Q
G
K
A
V
A
F
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
I
H
S
R
S
N
D
L
T
V
N
C
L
T
G
K
K
L
T
N
M
R
A
S
-
T
D
E
A
V
V
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
A
N
R
A
----
60
HHSearch
56.94
22%
-87
- C1 -
2H5E
1
RF3_ECOLI
A:
[9-472]
--
E
V
A
K
R
R
T
F
A
I
I
S
H
P
D
A
G
K
T
T
I
T
E
K
V
L
L
F
G
Q
-----------------------------------
I
T
T
S
V
M
Q
F
P
Y
-----------------------
H
-----------------------
D
C
L
V
N
L
L
D
T
P
G
H
E
D
F
S
E
D
T
Y
R
T
L
T
A
V
D
C
C
L
M
V
I
D
A
A
K
G
--
V
E
D
R
T
R
K
L
M
E
V
T
R
L
R
D
-
T
-
P
I
L
T
F
M
N
K
L
D
R
D
I
R
D
----
P
-------
M
E
L
L
D
E
V
E
N
E
L
----------------------------------------------
K
---------------------------------------------------------------------------
I
G
-------------------------------------------------------
C
A
P
I
T
W
P
I
--------
G
CGKLFK
G
V
Y
H
LYKD
E
T
Y
L
----------------------------
Y
Q
S
GKGHTIQE
V
R
I
V
K
G
LNN
P
D
L
D
A
A
VG
E
D
L
A
Q
Q
L
R
D
E
L
E
L
V
K
G
A
S
NEFD-----------------------------
K
E
L
F
L
-------------------
A
G
E
I
T
P
V
F
F
G
T
A
L
G
N
------------------------------------------------------------------------------------------------------------------------------------------
F
G
V
-
D
H
M
L
D
G
L
V
E
W
------------------
A
P
A
P
-----
M
P
R
Q
T
DT
R
T
V
E
------------------
A
---------
S
E
D
K
F
T
G
F
V
F
K
I
Q
A
N
MD
P
--
K
----
H
---
R
-
D
R
--------
V
A
F
M
R
V
V
S
G
K
Y
E
K
G
M
K
L
R
Q
V
R
T
A
-----------------------
K
D
V
V
-
I
S
D
A
L
T
F
M
--
A
-----
V
E
E
A
Y
P
G
D
I
L
G
L
----
H
---
N
----
H
--
G
--
T
-
I
Q
I
G
D
T
F
T
Q
G
E
----
M
--
M
K
F
-
T
G
I
P
-
N
F
A
P
E
L
F
R
R
I
R
L
K
---------
D
P
---
K
Q
L
L
K
G
L
V
Q
L
S
E
E
G
A
-
V
Q
V
F
R
P
I
S
N
N
D
L
I
V
G
A
V
G
V
L
Q
F
D
V
V
V
A
R
L
K
S
E
Y-
N
V
E
A
V
Y
-----
E
S
V
N
V
---
A
-
T
A
R
-
W
-------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-----------------------------------------------------------------------------------------------------------
E
C
A
D
-----------------
A
K
K
F
E
E
F
K
R
K
--
N
E
S
Q
L
A
L
D
G
G
D
N
L
A
Y
I
A
---
T
S
M
V
N
L
R
L
A
-
Q
E
R
Y
P
D
V
Q
F
H
Q
T
R
E
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------
81
Fugue
56.92
22%
-69
- C1 -
3CB4
-
LEPA_ECOLI
A:
[1-555]
---
M
K
N
I
R
N
F
S
I
I
A
H
I
S
----
T
L
S
D
R
I
I
Q
I
C
G
--------------------------------
G
Q
S
V
T
L
D
Y
K
A
S
D
G
-----------------------
E
-----------------------
T
Y
Q
L
N
F
I
D
T
P
G
H
V
D
F
S
Y
E
V
S
R
S
L
A
A
C
E
G
A
L
L
V
V
D
A
G
Q
G
--
V
E
A
Q
T
L
A
N
C
Y
T
A
M
E
M
D
-
L
-
E
V
V
P
V
L
N
K
I
D
L
P
A
A
D
----
P
-------
E
R
V
A
E
E
I
E
D
I
V
--------------------------------------------------------------------------------------------------------------------------
G
--------------------------------------------------------
I
---------------
D
----------------------------------------------
A
--------------------------------------------
T
---------------------------------
D
-----------------------------
A
V
R
C
S
A
K
T
G
------------------------------------------------------------------------------------------------------------------------------------------
V
G
V
-
Q
D
V
L
E
R
L
V
R
D
------------------
I
P
P
P
-----
E
G
---------------------------
D
---------
P
E
G
P
L
Q
A
L
I
I
D
S
W
F
---
D
--
N
----
Y
---
L
-
G
V
--------
V
S
L
I
R
I
K
N
G
T
L
R
K
G
D
K
V
K
V
M
S
-
T
G
-----
Q
------
T
---------
Y
N
A
D
R
L
G
I
F
T
P
------
K
Q
V
D
R
T
E
L
K
C
G
E
V
G
W
L
V
C
AI
K
---
D
----
I
--
H
--
G
-
A
P
V
G
D
T
L
T
L
A
R
---
N
P
--
A
E
K
-
A
L
P
G
-
F
K
K
V
K
P
Q
V
Y
A
G
L
--
F
P
V
S
S
D
D
Y
E
A
F
R
D
A
L
G
K
L
S
L
-
N
D
A
S
L
F
Y
E
P
E
S
S
S
A
L
G
-
F
G
F
R
C
G
F
L
G
L
L
H
M
E
I
I
Q
E
R
L
E
R
E
Y-
D
L
D
L
I
T
-----
T
A
P
T
V
V
Y
E
V
-
E
T
T
-
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----------------------------------------------------------------------------------------------------------
E
V
I
Y
V
DSPSKLPAVNNIY
E
L
R
E
P
I
A
E
C
H
M
L
L
--
P
Q
A
Y
L
G
N
V
I
T
L
C
V
E
K
R
G
---
V
Q
T
N
M
V
Y
H
G
-
N
-
Q
V
A
L
T
Y
E
I
P
M
A
E
V
V
L
D
F
F
D
R
L
K
S
T
S
R
G
Y
A
S
L
D
Y
N
F
K
R
F
Q
A
S
D
-----
M
V
R
V
D
V
L
I
N
G
E
R
V
D
A
L
A
--------------------------------------
L
I
T
H
R
D
N
S
Q
N
R
G
R
E
L
V
E
K
M
K
D
L
I
P
R
Q
Q
F
----------
D
I
A
I
Q
A
A
I
G
T
H
I
I
A
R
S
T
V
K
Q
L
R
K
N
V
L
A
K
C
Y
G
--
59
HHSearch
55.88
23%
-62
- C1 -
3TR5
2
RF3_COXBU
A:
[8-514]
-
K
Q
T
A
M
R
R
T
F
A
I
I
S
H
P
D
A
G
K
T
T
L
T
E
K
L
L
L
F
G
G
A
I
Q
L
A
G
------
T
I
K
S
R--
H
A
T
S
D
W
M
E
L
E
K
Q
R
G
I
S
V
T
T
S
V
M
Q
F
P
Y
-----------------------
K
-----------------------
D
Y
L
I
N
L
L
D
T
P
G
H
A
D
F
T
E
D
T
Y
R
T
L
T
A
V
D
S
A
L
M
V
I
D
A
A
K
G
--
V
E
P
R
T
I
K
L
M
E
V
C
R
L
R
H
-
T
-
P
I
M
T
F
I
N
K
M
D
R
D
T
R
P
----
S
-------
I
E
L
L
D
E
I
E
S
I
L
----------------------------------------------
R
---------------------------------------------------------------------------
I
--------------------------------------------------------
H
---------------
C
----------------------------------------------
A
P
V
T
W
P
I
G
MGKYFK
G
I
Y
H
LIED
A
I
Y
L
Y
Q
P
GKHERVGE
S
E
R
I
E
G
IN
N
P
E
L
D
K
K
L
G
D
L
A
S
E
L
R
N
E
I
E
L
V
K
G
ASHPFE
R
E
G
Y
L
-----------------------
K
G
E
L
T
P
I
F
F
G
S
A
I
N
N
------------------------------------------------------------------------------------------------------------------------------------------
F
G
V
-
G
E
L
L
D
A
F
V
K
E
------------------
A
P
P
P
-----
Q
G
---------------------------
R
E
T
N
S
R
L
V
K
P
E
E
E
K
F
S
G
F
V
F
K
I
Q
A
---
N
MD
G
----
H
---
R
-
D
R
--------
I
A
F
L
R
I
A
S
G
Q
Y
Q
K
G
M
K
A
Y
H
V
R
L
K
-----------------------
K
E
I
Q
-
I
N
N
A
L
T
F
M
--
A
G
K
R
E
N
A
E
E
A
W
P
G
D
I
I
G
L
----
H
---
N
----
H
--
G
--
T
-
I
Q
I
G
D
T
F
T
Q
G
E
----
R
--
F
K
F
-
T
G
I
P
-
N
F
A
S
E
L
F
R
L
V
R
L
K
D
P
---------
L
K
Q
K
A
L
L
K
G
L
T
Q
L
S
E
E
G
A
T
Q
L
F
R
P
-
L
D
S
N
E
L
I
L
G
A
V
G
L
L
Q
F
D
V
V
A
Y
R
L
E
N
E
Y-
N
V
K
C
V
Y
-----
E
S
V
N
V
---
V
T
A
R
W
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
C
D
--
D
----
K
A
V
L
E
R
F
N
Q
E
-----
Q
S
R
N
L
A
Y
D
---
G
G
G
H
L
T
Y
L
A
P
S
R
V
N
L
-
E
I
T
M
E
K
W
P
E
I
Q
F
S
E
T
R
E
H
--------------------------------------------------------------------------------------------------------------------------------------------
83
Fugue
54.20
25%
-44
- C1 -
4M1K
2
?
A:
[6-688]
E
Y
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
-----------------------------------
I
A
A
V
T
T
C
F
W
-----------------------
K
-----------------------
D
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
--
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
-
V
-
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
----
L
-------
W
L
V
I
R
T
M
Q
E
R
L
GARPVVM
Q
L
P
I
G
REDTFS
G
I
I
D
VLRM
K
A
Y
T
Y
GNDLGTDIREIPIPE
E
---------------------------------------------------------------------------
Y
--------------------------------------------------------
L
---------------
D
----------------------------------------------
Q
--------------------------------------------
A
---------------------------------
R
-----------------------
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
------------------
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
K
G
T
I
D
LK
I
T
P
V
F
L
G
S
AL
K
N
-------------------------------------------------------------------------------
K
G
V
-
Q
L
L
L
D
A
V
V
D
Y
LPSPLD
I
P
P
I
K
G
T
T
PEG
E
V
V
E
I
-----
H
P
---------------------------
D
---------
P
N
G
P
L
A
A
L
A
F
K
I
M
A
---
D
--
P
----
Y
---
V
-
G
R
--------
L
T
F
I
R
V
Y
S
G
--
T
L
T
S
G
S
Y
V
Y
N
T
T
K
-----
G
-----------------
R
K
E
R
V
A
R
L
L
R
M
H
--
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
----
V
---
G
----
L
--
K
--
E
-
T
I
T
G
D
T
L
V
G
E
D
---
A
P
--
R
V
I
L
E
S
I
E
-
V
P
E
P
V
I
D
V
A
I
E
---------
P
K
T
K
A
D
Q
E
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
E
T
G
Q
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F-
K
V
D
A
N
V
-----
G
K
P
Q
V
---
A
-
Y
R
E
-
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-----------------------------------------------------------------------------------------------------------
T
K
P
V
-----------------
D
V
E
G
K
F
I
R
L
T
GG
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
P
R
G
S
G
F
E
F
V
N
A
I
V
G
G
-
V
I
P
K
E
Y
I
P
A
V
Q
K
G
I
E
E
-
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
-------
G
S
Y
H
E
V
D
S
S
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
--
V
I
L
E
P
I
M
R
V
E
V
T
T
P
-
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
-
Q
I
L
G
M
E
P
R
G
N
A
Q
V
I
R
A
F
V
P
----
L
A
E
M
F
G
Y
--
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
K
Q
V
Q
E
K
L
I
-
78
HHSearch
54.19
25%
-108
- C1 -
1S0U
1
IF2G_METJA
A:
[5-314]
---
S
Q
A
E
V
N
I
G
M
V
G
H
V
D
H
G
K
T
S
L
T
K
A
L
T
G
V
W
T
-----------------------
D
-------
R
G
I
S
I
R
L
G
Y
A
D
C
E
I
R
K
C
PQCGTYTTKPRCPNCL
A
E
T
E
F
-----------------------
L
R
R
V
S
F
V
D
S
P
G
H
E
T
L
M
A
T
M
L
S
G
A
S
L
M
D
G
A
I
L
V
I
A
A
N
E
P
C-
P
Q
P
Q
T
K
E
H
L
M
A
L
E
I
L
G
-
I
D
K
I
I
I
V
Q
N
K
I
D
L
V
D
E
K
Q
---
A
-------
E
E
N
Y
E
Q
I
K
E
F
V
----------------------------------------------
K
---------------------------------------------------------------------------
G
--------------------------------------------------------
T
---------------
I
----------------------------------------------
A
--------------------------------------------------------------------------------------------------------
E
N
A
P
I
I
P
I
------------------------------------------------------------------------------------------------------------------------------------------------
N
I
-
D
V
L
L
K
A
I
Q
D
F
------------------
I
P
T
P
-----
K
R
---------------------------
D
---------
P
D
A
T
P
R
M
Y
V
A
R
S
F
D
---
I
--
N
----
K
---
P
-
G
T
EIKDLKGG
V
L
G
G
A
I
I
Q
G
V
F
K
V
G
D
E
I
E
I
R
P
G
I
K
-----
V
------
T
E
GNKT
F
W
K
P
L
T
T
K
-
I
V
S
L
A
A
G
------
N
T
I
L
R
K
A
H
P
G
G
L
I
G
V
G
T
--
T
LDP
Y
----
L
TK
S
--
D
-
A
L
T
G
S
V
V
G
L
P
G
---
T
L
--
P
P
I
-
R
E
K
I
-
T
I
R
A
N
L
L
D
R
V
V
G
T
K
E
E
L
K
I
E
P
L
R
T
G
E
V
L
M
L
N
I
G
T
A
T
T
A
G
V
I
T
S
A
R
G
D
I
A
D
I
K
L
K
L
P
I
C
A
E
I
G
D
R
V
A
I
S
R
R
V
G
S
R
W
--
R
L
I
G
Y
G
-----
T
I
E
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
HHSearch
54.06
23%
-79
- C1 -
3VQT
1
RF3_DESVM
A:
[27-495]
--
E
A
A
R
R
R
T
F
A
I
I
S
H
P
D
A
G
K
T
T
L
T
E
K
L
L
L
F
G
G
A
I
Q
M
A
G
------
S
V
K
A
R------------------
V
T
T
S
V
M
Q
F
P
Y
-----------------------
R
-----------------------
D
R
V
V
N
L
L
D
T
P
G
H
Q
D
F
S
E
D
T
Y
R
V
L
T
A
V
D
S
A
L
V
V
I
D
A
A
K
G
--
V
E
A
Q
T
R
K
L
M
D
V
C
R
M
R
A
-
T
-
P
V
M
T
F
V
N
K
M
D
R
E
A
L
H
----
P
-------
L
D
V
M
A
D
I
E
Q
H
L
----------------------------------------------
Q
---------------------------------------------------------------------------
I
--------------------------------------------------------
E
C
--------------
A
P
M
T
W
P
I
G
MGSSFK
G
T
Y
D
LLHK
Q
L
H
L
F
SQ
S
G
I
V
I
H
G
ADDP
Q
L
D
E
Y
LG
D
--------------------------------------------
Q
---------------------------------
A
E
Q
L
R
M
D
L
A
L
L
E
E
A
G
T
P
FD
E
E
R
Y
L
K
G
E
L
T
P
V
F
F
G
S
A
I
N
N
------------------------------------------------------------------------------------------------------------------------------------------
F
G
V
-
R
E
M
L
D
M
F
V
E
F
------------------
A
P
G
P
-----
Q
P
R
P
A
AT
R
V
V
E
------------------
P
---------
G
E
E
A
F
T
G
V
V
F
K
I
Q
A
---
N
--------------
R
--------
M
A
F
L
R
I
C
S
G
T
F
T
R
G
M
R
L
K
H
H
R
T
G
-----------------------
K
D
V
T
-
V
A
N
A
T
I
F
M
--
A
Q
D
R
T
G
V
E
E
A
F
P
G
D
I
I
G
I
----
P
---
N
----
H
--
G
--
T
-
I
K
I
G
D
T
F
T
E
S
K
---
E
V
--
L
K
F
-
V
G
I
P
-
N
F
A
P
E
H
F
R
R
V
R
L
K
N
---------
P
L
K
A
K
Q
L
Q
K
G
L
E
Q
L
A
E
E
G
A
V
Q
-
L
F
R
P
L
V
N
N
D
Y
I
L
G
A
V
G
V
L
Q
F
D
V
I
V
A
R
L
A
D
E
Y-
G
V
D
A
V
Y
E
G
V
ST
H
T
A
R
W
---
V
-
Y
C
E
-
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----------------------------------------------------------------------------------------------------------
K
I
F
A
-----------------
D
F
Q
D
Y
H
R
G
E
L
--
A
V
D
A
E
G
A
L
A
Y
L
A
P
N
P
W
R
---
L
E
S
A
M
E
R
Y
P
-
K
V
E
F
R
T
T
R
E
I
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
HHSearch
52.03
26%
-84
- C1 -
1KK1
3
IF2G_PYRAB
A:
[7-316]
---
R
Q
A
E
V
N
I
G
M
V
G
H
V
D
H
G
K
T
T
L
T
K
A
L
T
G
V
-----------------------
W
T
D
--
S
E
E
L
R
R
G
I
T
I
K
I
G
F
A
D
A
E
I
-----------------------
R
R
C
PNCGRYSTSPVCPYCG
H
E
T
E
F
V
R
R
V
S
F
I
D
A
P
G
H
E
A
L
M
T
T
M
L
A
G
A
S
L
M
D
G
A
I
L
V
I
A
A
N
E
P
C-
P
R
P
Q
T
R
E
H
L
M
A
L
Q
I
I
G
Q
K
-
N
I
I
I
A
Q
N
K
I
E
L
V
D
K
E
K
---
A
-------
L
E
N
Y
R
Q
I
K
E
F
I
----------------------------------------------
E
---------------------------------------------------------------------------
G
--------------------------------------------------------
T
---------------
V
------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
N
A
P
I
I
P
I
S
A
L
H
G
------------------------------------------------------------------------------------------------------------------------------------------
A
N
I
-
D
V
L
V
K
A
I
E
D
F
------------------
I
P
T
P
-----
K
R
---------------------------
D
---------
P
N
K
P
P
K
M
L
V
L
R
S
F
D
---
V
--
N
KPGK
L
---
V
-
G
G
--------
V
L
D
G
S
I
V
Q
G
K
L
K
V
G
D
E
I
E
I
R
P
G
V
P
Y
E
E
HG
R
------
I
K
Y
E
P
-----
I
T
T
E
-
I
V
S
L
Q
A
G
------
G
Q
F
V
E
E
A
Y
P
G
G
L
V
G
V
G
---
T
---
K
LDPY
L
--
T
KG
D
-
L
M
A
G
N
V
V
G
K
P
G
---
K
L
--
P
P
V
-
W
D
S
L
-
R
L
E
V
H
L
L
E
R
V
V
E
Q
E
L
K
V
E
P
I
K
R
K
E
V
L
L
L
N
V
G
T
A
R
T
M
G
L
V
T
G
L
G
K
D
E
I
E
V
K
L
Q
I
P
V
C
A
E
P
G
D
R
V
A
I
S
R
Q
I
G
S
R
W
R
L
--
I
G
Y
G
I
I
-----
K
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
HHSearch
50.07
20%
-110
- C1 -
3P26
-
HBS1_YEAST
A:
[164-496]
---
A
L
P
H
L
S
F
V
V
L
G
H
V
D
A
G
K
S
T
L
M
G
R
L
L
Y
D
L
N
I
V
N
Q
S
Q
L
R
K
L
QR-------------------
R
G
V
T
V
S
I
C
T
S
H
F
S
T
-----------------------
H
-----------------------
R
A
N
F
T
I
V
D
A
P
G
H
R
D
F
V
P
N
A
I
M
G
I
S
Q
A
D
M
A
I
L
C
V
D
C
S
T
-FD
L
D
G
Q
T
K
E
H
M
L
L
A
S
S
L
G
-
I
H
N
L
I
I
A
M
N
K
M
D
N
V
D
W
S
Q
Q
R
-
F
-------
E
E
I
K
S
K
L
L
P
Y
L
----------------------------------------------
V
---------------------------------------------------------------------------
D
--------------------------------------------------------
I
---------------
G
----------------------------------------------
F
--------------------------------------------
F
---------------------------------
E
-------------------------
D
N
I
N
W
V
P
I
S
G
F
S
G
E
G
V
Y
K
I
E
Y
T
D
E
V
-------------
R
-------------------------------
Q
W
-------------------------------------------------------------------------------
Y
N
G
-
P
N
L
M
S
T
L
E
N
A
------------------
A
F
K
I
S
K
E
N
E
G
I
---------------------------
N
---------
K
D
D
P
F
L
F
S
V
L
E
I
I
P
------------TSN
D
-
L
A
--------
L
V
S
G
K
L
E
S
G
S
I
Q
P
G
E
S
L
T
I
Y
P
S
E
-----------------------
Q
S
C
I
-
V
D
K
I
Q
V
G
S
QQ---
H
E
E
T
D
V
A
I
K
G
D
F
V
T
L
KL--
R
---
K
----
A
--
Y
PE
D
-
I
Q
N
G
D
L
A
A
S
V
D
---
Y
S
--
S
I
H
-
S
A
Q
C
-
F
V
L
E
L
T
T
F
D
M
N
R
P
L
L
P
G
T
P
F
I
L
F
I
G
V
K
E
Q
P
A
R
I
K
R
L
I
S
F
I
D
K
G
N
T
A
S
K
K
K
I
R
H
L
G
S
K
Q
R
A
F
V
E
I
E
L
I
E
V
K
R
W
I
P
L
--
L
T
A
H
E
N
-----
D
R
L
G
R
---
V
-
V
L
R
-
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----------------------------------------------------------------------------------------------------------
G
R
T
I
-----------------
A
A
G
K
I
S
E
I
T
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------