@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0073: (2015-11-28 )
MTIIIDGKKIASGLCEKLSQRIDVLKREHSIFPCLKVIFVGNNPASQVYVRNKQKKAESIGISSETIVLPDNILENELIEKINELNNDRFVNGILVQLPLPNHINASKVINTVSVEKDVDAFHRENVGKLVKGEKNCLVPCTPKGALHLIKLVETNLSGKNAVVIGRSNIVGKPMFHLLLQENCTVTILHSQSKDLAEYCSKADVVVTAVGKPNFVQEGWIKEGAIVIDVGINSVSIEGKTKLIGDVDFDRVKEKTKAITPVPGGVGPMTIAFLMINTVIAACLQKKVDASDFVS
Atome Classification :
(28 SA)
-.........10........20......-.-.-30..-.......40........50........60........70........80........90........100.--.--.......110.......120.......130...-..-...140.......150.......160.-......170.......180.......190-...--.....200.......210.......220.......230...---....240-.---........250.......260.......270.......280.......290...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-
M
T
I
I
ID
G
K
K
I
A
S
G
L
C
E
K
L
S
Q
R
I
D
V
L
K
R-E-H-
S
-
I
F
-
P
C
L
K
V
I
F
VGNNPA
S
Q
V
Y
V
RNKQK
K
A
E
SIGISS
E
T
I
VLP
D
N
I
L
E
N
E
L
I
E
K
I
N
ELNNDRF
V
N
G
I
L
V
QLPL--P--N--HI
N
A
S
K
V
I
N
T
V
SVE
K
D
V
D
A
F
H
R
E
N
V
G
K
L
-VKGE-KN-
C
L
V
PCTPK
G
A
L
H
L
I
K
L
V
ETNLSGK
N
A
V
-
V
I
GRSNIV
G
K
P
M
F
H
L
L
L
QEN
C
T
V
T
I
L
HS--QS
K
--
D
L
A
E
Y
CSKA
D
V
V
V
T
AVGKPN
F
V
Q
EGWIKE
G
A
I
V
I
D
VGI
N
S
V
---
S
IEGK---
T
---
K
L
IGDV
D
F
D
R
V
K
E
K
TKAITPVPGGV
G
P
M
T
I
A
F
L
M
I
N
T
V
I
A
A
C
L
Q
KKVDASDFVS
21
PsiBlast_CBE
96.73
49%
-117
- C7 -
3L07
4
FOLD_FRATT
B:
[5-282]
---
I
L
I
D
G
K
S
L
S
K
D
L
K
E
R
L
A
T
Q
V
Q
E
Y
K
H
-
H
-
T
-
A
-
I
T
-
P
K
L
V
A
I
I
V
G
N
D
P
A
S
K
T
Y
V
A
S
K
E
K
A
C
A
Q
V
G
I
D
S
Q
V
I
T
L
P
E
H
T
T
E
S
E
L
L
E
L
I
D
Q
L
N
N
D
S
S
V
H
A
I
L
V
Q
L
P
L
--
P
--
A
--
H
I
N
K
N
N
V
I
Y
S
I
K
P
E
K
D
V
D
G
F
H
P
T
N
V
G
R
L
-
Q
L
R
D
-
K
K
-
C
L
E
S
C
T
P
K
G
I
M
T
M
L
R
E
Y
G
I
K
T
E
G
A
Y
A
V
-
V
V
G
A
S
N
V
V
G
K
P
V
S
Q
L
L
L
N
A
K
A
T
V
T
T
C
H
R
--
F
T
T
--
D
L
K
S
H
T
T
K
A
D
I
L
I
V
A
V
G
K
P
N
F
I
T
A
D
M
V
K
E
G
A
V
V
I
D
V
G
I
N
H
V
---
D
-------
G
---
K
I
V
G
D
V
D
F
A
A
V
K
D
K
V
A
A
I
T
P
V
P
G
G
V
G
P
M
T
I
T
E
L
L
Y
N
T
F
--
Q
C
A
Q
E
L
N
R
------
1
PsiBlast_PDB
96.37
49%
-118
- C7 -
3L07
4
FOLD_FRATT
A:
[5-282]
---
I
L
I
D
G
K
S
L
S
K
D
L
K
E
R
L
A
T
Q
V
Q
E
Y
K
H
-
H
-
T
-
A
-
I
T
-
P
K
L
V
A
I
I
V
G
N
D
P
A
S
K
T
Y
V
A
S
K
E
K
A
C
A
Q
V
G
I
D
S
Q
V
I
T
L
P
E
H
T
T
E
S
E
L
L
E
L
I
D
Q
L
N
N
D
S
S
V
H
A
I
L
V
Q
L
P
L
--
P
--
A
--
H
I
N
K
N
N
V
I
Y
S
I
K
P
E
K
D
V
D
G
F
H
P
T
N
V
G
R
L
-
Q
L
R
D
-
K
K
-
C
L
E
S
C
T
P
K
G
I
M
T
M
L
R
E
Y
G
I
K
T
E
G
A
Y
A
V
-
V
V
G
A
S
N
V
V
G
K
P
V
S
Q
L
L
L
N
A
K
A
T
V
T
T
C
H
R
--
F
T
T
--
D
L
K
S
H
T
T
K
A
D
I
L
I
V
A
V
G
K
P
N
F
I
T
A
D
M
V
K
E
G
A
V
V
I
D
V
G
I
N
H
V
---
D
-------
G
---
K
I
V
G
D
V
D
F
A
A
V
K
D
K
V
A
A
I
T
P
V
P
G
G
V
G
P
M
T
I
T
E
L
L
Y
N
T
F
--
Q
C
A
Q
E
L
N
-------
5
PsiBlast_PDB
95.74
47%
-116
- C7 -
1DIA
2
C1TC_HUMAN
A:
[6-291]
----
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
E
-
Q
-
V
-
P
-
G
F
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
DS
E
--
N
--
S
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
-
A
R
G
D
-
L
N
D
C
F
I
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
A
V
-
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
W
N
N
A
T
V
T
T
C
H
S
--
K
T
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
N
Y
----------------
K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
E
S
A
K
R
F
L
E
--------
35
HHSearch
95.47
50%
-114
- C7 -
3L07
4
FOLD_FRATT
A:
[4-284]
--
M
I
L
I
D
G
K
S
L
S
K
D
L
K
E
R
L
A
T
Q
V
Q
E
Y
K
H
-
H
-
T
-
A
-
I
T
-
P
K
L
V
A
I
I
V
G
N
D
P
A
S
K
T
Y
V
A
S
K
E
K
A
C
A
Q
V
G
I
D
S
Q
V
I
T
L
P
E
H
T
T
E
S
E
L
L
E
L
I
D
Q
L
N
N
D
S
S
V
H
A
I
L
V
Q
L
P
L
--
P
--
A
--
H
I
N
K
N
N
V
I
Y
S
I
K
P
E
K
D
V
D
G
F
H
P
T
N
V
G
R
L
-
Q
L
R
D
-
K
K
-
C
L
E
S
C
T
P
K
G
I
M
T
M
L
R
E
Y
G
I
K
T
E
G
A
Y
A
V
-
V
V
G
A
S
N
V
V
G
K
P
V
S
Q
L
L
L
N
A
K
A
T
V
T
T
C
H
R
--
F
T
T
--
D
L
K
S
H
T
T
K
A
D
I
L
I
V
A
V
G
K
P
N
F
I
T
A
D
M
V
K
E
G
A
V
V
I
D
V
G
I
N
H
V
---
D
G
----------
K
I
V
G
D
V
D
F
A
A
V
K
D
K
V
A
A
I
T
P
V
P
G
G
V
G
P
M
T
I
T
E
L
L
Y
N
T
F
Q
C
A
Q
E
L
N
---------
7
PsiBlast_PDB
95.21
47%
-114
- C7 -
1DIG
2
C1TC_HUMAN
A:
[6-291]
----
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
E
-
Q
-
V
-
P
-
G
F
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
DS
E
--
N
--
S
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
-
A
R
G
D
-
L
N
D
C
F
I
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
A
V
-
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
W
N
N
A
T
V
T
T
C
H
S
--
K
T
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
N
Y
----------------
K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
E
S
A
K
R
F
L
E
--------
23
PsiBlast_CBE
94.51
47%
-112
- C7 -
1DIB
1
C1TC_HUMAN
B:
[6-291]
----
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
E
-
Q
-
V
-
P
-
G
F
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
DS
E
--
N
--
S
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
-
A
R
G
D
-
L
N
D
C
F
I
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
A
V
-
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
W
N
N
A
T
V
T
T
C
H
S
--
K
T
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
N
Y
V
---
P
D
D
K
K
PNG
R
---
K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
E
S
A
K
R
F
L
E
--------
22
PsiBlast_CBE
94.51
47%
-114
- C7 -
1DIG
2
C1TC_HUMAN
B:
[6-291]
----
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
E
-
Q
-
V
-
P
-
G
F
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
DS
E
--
N
--
S
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
-
A
R
G
D
-
L
N
D
C
F
I
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
A
V
-
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
W
N
N
A
T
V
T
T
C
H
S
--
K
T
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
N
Y
V
---
P
D
D
K
K
PNG
R
---
K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
E
S
A
K
R
F
L
E
--------
6
PsiBlast_PDB
94.48
47%
-113
- C7 -
1DIB
2
C1TC_HUMAN
A:
[6-291]
----
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
E
-
Q
-
V
-
P
-
G
F
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
DS
E
--
N
--
S
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
-
A
R
G
D
-
L
N
D
C
F
I
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
A
V
-
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
W
N
N
A
T
V
T
T
C
H
S
--
K
T
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
N
Y
----------------
K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
E
S
A
K
R
F
L
E
--------
55
Fugue
94.41
47%
-110
* C7 *
1A4I
1
C1TC_HUMAN
A:
[2-296]
A
P
A
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
E
-
Q
V
P
-
G
-
F
T
-
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
--
D
SE
N
--
S
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
-
A
R
G
D
-
L
N
D
C
F
I
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
A
V
-
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
W
N
N
A
T
V
T
T
C
H
S
--
K
T
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
N
Y
----------------
K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
E
S
A
K
R
F
L
E
--------
24
PsiBlast_CBE
94.17
47%
-112
- C7 -
1DIA
1
C1TC_HUMAN
B:
[6-291]
----
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
E
-
Q
-
V
-
P
-
G
F
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
DS
E
--
N
--
S
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
-
A
R
G
D
-
L
N
D
C
F
I
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
A
V
-
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
W
N
N
A
T
V
T
T
C
H
S
--
K
T
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
N
Y
V
---
P
D
D
K
K
PNG
R
---
K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
E
S
A
K
R
F
L
E
--------
25
PsiBlast_CBE
94.16
47%
-110
- C7 -
1A4I
1
C1TC_HUMAN
B:
[6-291]
----
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
E
-
Q
-
V
-
P
-
G
F
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
DS
E
--
N
--
S
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
-
A
R
G
D
-
L
N
D
C
F
I
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
A
V
-
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
W
N
N
A
T
V
T
T
C
H
S
--
K
T
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
N
Y
V
---
P
D
D
K
K
PNG
R
---
K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
E
S
A
K
R
F
L
E
--------
37
HHSearch
94.06
48%
-115
- C7 -
3P2O
2
FOLD_CAMJE
A:
[4-284]
--
M
T
L
L
D
G
K
A
L
S
A
K
I
K
E
E
L
K
E
K
N
Q
F
L
K
S
---
K
-
G
-
I
E
-
S
C
L
A
V
I
L
V
G
D
N
P
A
S
Q
T
Y
V
K
S
K
A
K
A
C
E
E
C
G
I
K
S
L
V
Y
H
L
N
E
N
I
T
Q
N
E
L
L
A
L
I
N
T
L
N
H
D
D
S
V
H
G
I
L
V
Q
L
P
L
--
P
--
D
--
H
I
C
K
D
L
I
L
E
S
I
I
S
S
K
D
V
D
G
F
H
P
I
N
V
G
Y
L
-
N
L
G
L
-
E
S
-
G
F
L
P
C
T
P
L
G
V
M
K
L
L
K
A
Y
E
I
D
L
E
G
K
D
A
V
-
I
I
G
A
S
N
I
V
G
R
P
M
A
T
M
L
L
N
A
G
A
T
V
S
V
C
H
I
--
K
T
K
--
D
L
S
L
Y
T
R
Q
A
D
L
I
I
V
A
A
G
C
V
N
L
L
R
S
D
M
V
K
E
G
V
I
V
V
D
V
G
I
N
R
L
---
E
S
G
---------
K
I
V
G
D
V
D
F
E
E
V
S
K
K
S
S
Y
I
T
P
V
P
G
G
V
G
P
M
T
I
A
M
L
L
E
N
T
V
K
S
A
K
N
R
L
---------
8
PsiBlast_PDB
93.83
47%
-112
- C7 -
1A4I
1
C1TC_HUMAN
A:
[6-291]
----
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
E
-
Q
-
V
-
P
-
G
F
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
DS
E
--
N
--
S
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
-
A
R
G
D
-
L
N
D
C
F
I
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
A
V
-
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
W
N
N
A
T
V
T
T
C
H
S
--
K
T
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
N
Y
----------------
K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
E
S
A
K
R
F
L
E
--------
36
HHSearch
92.81
45%
-110
- C7 -
1A4I
1
C1TC_HUMAN
A:
[3-296]
-
P
A
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
E
Q
V
-
P
-
G
-
F
T
-
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
--
D
--
S
EN
S
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
-
A
R
G
D
L
N
D
-
C
F
I
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
A
V
-
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
W
N
N
A
T
V
T
T
C
H
S
--
K
T
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
N
Y
----------------
K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
E
S
A
K
R
F
L
E
--------
3
PsiBlast_PDB
92.63
47%
-115
- C7 -
3P2O
2
FOLD_CAMJE
A:
[6-280]
----
L
L
D
G
K
A
L
S
A
K
I
K
E
E
L
K
E
K
N
Q
F
L
K
S
-
K
---
G
-
I
E
-
S
C
L
A
V
I
L
V
G
D
N
P
A
S
Q
T
Y
V
K
S
K
A
K
A
C
E
E
C
G
I
K
S
L
V
Y
H
L
N
E
N
I
T
Q
N
E
L
L
A
L
I
N
T
L
N
H
D
D
S
V
H
G
I
L
V
Q
L
P
L
--
P
--
D
--
H
I
C
K
D
L
I
L
E
S
I
I
S
S
K
D
V
D
G
F
H
P
I
N
V
G
Y
L
-
N
L
G
L
-
E
S
-
G
F
L
P
C
T
P
L
G
V
M
K
L
L
K
A
Y
E
I
D
L
E
G
K
D
A
V
-
I
I
G
A
S
N
I
V
G
R
P
M
A
T
M
L
L
N
A
G
A
T
V
S
V
C
H
I
--
K
T
K
--
D
L
S
L
Y
T
R
Q
A
D
L
I
I
V
A
A
G
C
V
N
L
L
R
S
D
M
V
K
E
G
V
I
V
V
D
V
G
I
N
R
L
---
E
---
S
---
G
---
K
I
V
G
D
V
D
F
E
E
V
S
K
K
S
S
Y
I
T
P
V
P
G
G
V
G
P
M
T
I
A
M
L
L
E
N
T
V
K
S
A
K
N
R
L
---------
4
PsiBlast_PDB
92.18
46%
-111
- C7 -
1B0A
-
FOLD_ECOLI
A:
[5-281]
----
I
I
D
G
K
T
I
A
Q
Q
V
R
S
E
V
A
Q
K
V
Q
A
R
I
A
-
A
-
G
-
L
-
R
A
-
P
G
L
A
V
V
L
V
G
S
N
P
A
S
Q
I
Y
V
A
S
K
R
K
A
C
E
E
V
G
F
V
S
R
S
Y
D
L
P
E
T
T
S
E
A
E
L
L
E
L
I
D
T
L
N
A
D
N
T
I
D
G
I
L
V
Q
L
P
L
--
P
--
A
--
G
I
D
N
V
K
V
L
E
R
I
H
P
D
K
D
V
D
G
F
H
P
Y
N
V
G
R
L
-
C
Q
R
A
-
P
R
--
L
R
P
C
T
P
R
G
I
V
T
L
L
E
R
Y
N
I
D
T
F
G
L
N
A
V
-
V
I
G
A
S
N
I
V
G
R
P
M
S
M
E
L
L
L
A
G
C
T
T
T
V
T
H
R
--
F
T
K
--
N
L
R
H
H
V
E
N
A
D
L
L
I
V
A
V
G
K
P
G
F
I
P
G
D
W
I
K
E
G
A
I
V
I
D
V
G
I
N
R
L
---
E
---
N
---
G
---
K
V
V
G
D
V
V
F
E
D
A
A
K
R
A
S
Y
I
T
P
V
P
G
G
V
G
P
M
T
V
A
T
L
I
E
N
T
-
L
Q
A
C
V
E
Y
H
D
P
Q
D
E
---
26
PsiBlast_CBE
90.79
43%
-115
- C7 -
4A26
1
?
B:
[8-292]
----
I
I
D
G
K
A
I
A
A
A
I
R
S
E
L
K
D
K
V
A
A
L
R
E
-
L
-
Y
-
G
G
R
V
-
P
G
L
A
S
I
I
V
G
Q
R
M
D
S
K
K
Y
V
Q
L
K
H
K
A
A
A
E
V
G
M
A
S
F
N
V
E
L
P
E
D
I
S
Q
E
V
L
E
V
N
V
E
K
L
N
N
D
P
N
C
H
G
I
I
V
Q
L
P
L
--
P
--
K
--
H
L
N
E
N
R
A
I
E
K
I
H
P
H
K
D
A
D
A
L
L
P
V
N
V
G
L
L
H
Y
K
G
R
-
E
P
-
P
F
T
P
C
T
A
K
G
V
I
V
L
L
K
R
C
G
I
E
M
A
G
K
R
A
V
-
V
L
G
R
S
N
I
V
G
A
P
V
A
A
L
L
M
K
E
N
A
T
V
T
I
V
H
S
GT
S
T
E
--
D
M
I
D
Y
L
R
T
A
D
I
V
I
A
A
M
G
Q
P
G
Y
V
K
G
E
W
I
K
E
G
A
A
V
V
D
V
G
T
T
P
V
PDP
S
---
G
---
Y
---
R
L
V
G
D
V
C
F
E
E
A
A
A
R
A
A
W
I
S
P
V
P
G
G
V
G
P
M
T
I
A
M
L
L
E
N
T
L
E
A
F
K
A
A
L
G
--------
39
HHSearch
90.74
46%
-110
- C7 -
1B0A
-
FOLD_ECOLI
A:
[2-283]
-
A
A
K
I
I
D
G
K
T
I
A
Q
Q
V
R
S
E
V
A
Q
K
V
Q
A
R
I
A
-
A
-
G
-
L
-
R
A
-
P
G
L
A
V
V
L
V
G
S
N
P
A
S
Q
I
Y
V
A
S
K
R
K
A
C
E
E
V
G
F
V
S
R
S
Y
D
L
P
E
T
T
S
E
A
E
L
L
E
L
I
D
T
L
N
A
D
N
T
I
D
G
I
L
V
Q
L
P
L
--
P
--
A
--
G
I
D
N
V
K
V
L
E
R
I
H
P
D
K
D
V
D
G
F
H
P
Y
N
V
G
R
L
-
C
Q
R
A
--
P
-
R
L
R
P
C
T
P
R
G
I
V
T
L
L
E
R
Y
N
I
D
T
F
G
L
N
A
V
-
V
I
G
A
S
N
I
V
G
R
P
M
S
M
E
L
L
L
A
G
C
T
T
T
V
T
H
R
--
F
T
K
--
N
L
R
H
H
V
E
N
A
D
L
L
I
V
A
V
G
K
P
G
F
I
P
G
D
W
I
K
E
G
A
I
V
I
D
V
G
I
N
R
L
---
E
N
G
---------
K
V
V
G
D
V
V
F
E
D
A
A
K
R
A
S
Y
I
T
P
V
P
G
G
V
G
P
M
T
V
A
T
L
I
E
N
T
L
Q
A
C
V
E
Y
H
D
P
Q
D
E
----
29
PsiBlast_CBE
90.31
39%
-117
- C7 -
4B4U
7
?
B:
[22-298]
-
M
A
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
K
A
-
K
-
T
-
G
-
R
T
-
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
--
P
--
A
--
Q
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
-
A
M
G
E
-
A
--
A
Y
G
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
K
H
A
V
-
V
V
G
R
S
A
I
L
G
K
P
M
A
M
M
L
L
Q
A
N
A
T
V
T
I
C
H
S
--
R
T
Q
--
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
F
H
P
R
---
D
G
G
G
----------
V
G
D
I
Q
L
Q
G
I
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
V
E
A
A
E
K
A
L
G
--------
30
PsiBlast_CBE
90.04
37%
-114
- C7 -
4CJX
2
?
B:
[25-309]
--
A
V
V
I
D
G
R
A
V
A
K
A
I
Q
K
E
L
T
E
E
V
A
L
L
E
R
-
R
-
Y
K
G
-
R
R
-
P
G
L
S
T
I
I
C
G
K
R
K
D
S
Q
T
Y
V
R
L
K
R
K
A
A
A
A
C
G
F
R
N
F
S
V
E
L
P
A
N
V
T
Q
E
A
L
E
R
E
V
I
R
L
N
E
E
E
A
C
H
S
I
V
V
Q
L
P
L
--
P
--
P
--
H
I
D
K
V
A
A
L
S
K
I
K
P
E
K
D
A
D
C
L
L
P
V
N
V
G
Q
L
-
H
I
R
E
-
R
N
P
A
I
V
P
C
T
A
S
A
V
M
E
L
L
R
C
S
G
V
E
I
C
G
K
R
V
V
-
V
L
G
R
G
D
I
A
G
L
P
V
A
T
L
L
A
N
E
D
A
T
V
T
V
V
H
S
--
A
T
P
LC
D
I
A
D
I
V
R
A
S
D
I
V
V
S
A
A
G
Q
P
G
L
V
R
G
E
W
I
K
L
G
A
A
V
I
D
V
G
T
T
P
V
---
A
D
P
S
K
---
V
PGY
R
L
V
G
D
V
C
F
D
V
A
R
K
R
A
A
Y
I
T
P
V
P
G
G
V
G
P
V
T
V
S
M
L
L
K
N
T
L
T
M
F
K
R
S
V
R
A
-------
27
PsiBlast_CBE
89.96
39%
-116
- C7 -
4B4W
3
?
B:
[22-298]
-
M
A
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
K
A
-
K
-
T
-
G
-
R
T
-
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
--
P
--
A
--
Q
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
-
A
M
G
E
-
A
--
A
Y
G
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
K
H
A
V
-
V
V
G
R
S
A
I
L
G
K
P
M
A
M
M
L
L
Q
A
N
A
T
V
T
I
C
H
S
--
R
T
Q
--
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
F
H
P
R
---
D
G
G
G
----------
V
G
D
I
Q
L
Q
G
I
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
V
E
A
A
E
K
A
L
G
--------
28
PsiBlast_CBE
89.92
39%
-117
- C7 -
4B4V
3
?
B:
[22-298]
-
M
A
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
K
A
-
K
-
T
-
G
-
R
T
-
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
--
P
--
A
--
Q
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
-
A
M
G
E
-
A
--
A
Y
G
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
K
H
A
V
-
V
V
G
R
S
A
I
L
G
K
P
M
A
M
M
L
L
Q
A
N
A
T
V
T
I
C
H
S
--
R
T
Q
--
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
F
H
P
R
---
D
G
G
G
----------
V
G
D
I
Q
L
Q
G
I
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
V
E
A
A
E
K
A
L
G
--------
11
PsiBlast_PDB
89.73
39%
-119
- C7 -
4B4V
4
?
A:
[22-298]
-
M
A
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
K
A
-
K
-
T
-
G
-
R
T
-
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
--
P
--
A
--
Q
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
-
A
M
G
E
-
A
--
A
Y
G
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
K
H
A
V
-
V
V
G
R
S
A
I
L
G
K
P
M
A
M
M
L
L
Q
A
N
A
T
V
T
I
C
H
S
--
R
T
Q
--
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
F
H
P
R
---
D
G
G
G
----------
V
G
D
I
Q
L
Q
G
I
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
V
E
A
A
E
K
A
L
G
--------
12
PsiBlast_PDB
89.28
39%
-115
- C7 -
4B4W
4
?
A:
[22-298]
-
M
A
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
K
A
-
K
-
T
-
G
-
R
T
-
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
--
P
--
A
--
Q
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
-
A
M
G
E
-
A
--
A
Y
G
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
K
H
A
V
-
V
V
G
R
S
A
I
L
G
K
P
M
A
M
M
L
L
Q
A
N
A
T
V
T
I
C
H
S
--
R
T
Q
--
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
F
H
P
R
---
D
G
G
G
----------
V
G
D
I
Q
L
Q
G
I
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
V
E
A
A
E
K
A
L
G
--------
13
PsiBlast_PDB
89.08
37%
-113
- C7 -
4CJX
4
?
A:
[25-309]
--
A
V
V
I
D
G
R
A
V
A
K
A
I
Q
K
E
L
T
E
E
V
A
L
L
E
R
-
R
-
Y
K
G
-
R
R
-
P
G
L
S
T
I
I
C
G
K
R
K
D
S
Q
T
Y
V
R
L
K
R
K
A
A
A
A
C
G
F
R
N
F
S
V
E
L
P
A
N
V
T
Q
E
A
L
E
R
E
V
I
R
L
N
E
E
E
A
C
H
S
I
V
V
Q
L
P
L
--
P
--
P
--
H
I
D
K
V
A
A
L
S
K
I
K
P
E
K
D
A
D
C
L
L
P
V
N
V
G
Q
L
-
H
I
R
E
-
R
N
P
A
I
V
P
C
T
A
S
A
V
M
E
L
L
R
C
S
G
V
E
I
C
G
K
R
V
V
-
V
L
G
R
G
D
I
A
G
L
P
V
A
T
L
L
A
N
E
D
A
T
V
T
V
V
H
S
--
A
T
P
L
C
D
I
A
D
I
V
R
A
S
D
I
V
V
S
A
A
G
Q
P
G
L
V
R
G
E
W
I
K
L
G
A
A
V
I
D
V
G
T
T
P
V
---
A
D
P
S
K
---
V
PG
Y
R
L
V
G
D
V
C
F
D
V
A
R
K
R
A
A
Y
I
T
P
V
P
G
G
V
G
P
V
T
V
S
M
L
L
K
N
T
L
T
M
F
K
R
S
V
R
A
-------
10
PsiBlast_PDB
88.79
39%
-114
- C7 -
4B4U
9
?
A:
[22-298]
-
M
A
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
K
A
-
K
-
T
-
G
-
R
T
-
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
--
P
--
A
--
Q
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
-
A
M
G
E
-
A
--
A
Y
G
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
K
H
A
V
-
V
V
G
R
S
A
I
L
G
K
P
M
A
M
M
L
L
Q
A
N
A
T
V
T
I
C
H
S
--
R
T
Q
--
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
F
H
P
R
---
D
G
G
G
----------
V
G
D
I
Q
L
Q
G
I
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
V
E
A
A
E
K
A
L
G
--------
16
PsiBlast_PDB
82.47
35%
-120
- C7 -
3NGL
1
FOLD_THEAC
A:
[3-273]
----
I
L
R
G
E
E
I
A
E
K
K
A
E
N
L
H
G
I
I
E
-----
R
-
S
-
G
-
L
E
-
P
S
L
K
L
I
Q
I
G
D
N
E
A
A
S
I
Y
A
R
A
K
I
R
R
G
K
K
I
G
I
A
V
D
-
L
E
K
Y
D
D
I
S
M
K
D
L
L
K
R
I
D
D
L
A
K
D
P
Q
I
N
G
I
M
I
E
N
P
L
--
P
--
K
--
G
F
D
Y
Y
E
I
V
R
N
I
P
Y
Y
K
D
V
D
A
L
S
P
Y
N
Q
G
-
L
-
I
A
L
N
-
R
E
-
F
L
V
P
A
T
P
R
A
V
I
D
I
M
D
Y
Y
G
Y
H
---
E
N
T
V
T
I
V
N
R
S
P
V
V
G
R
P
L
S
M
M
L
L
N
R
N
Y
T
V
S
V
C
H
S
--
K
T
K
--
D
I
G
S
M
T
R
S
S
K
I
V
V
V
A
V
G
R
P
G
F
L
N
R
E
M
V
T
P
G
S
V
V
I
D
V
G
I
N
Y
V
---
N
-------
D
---
K
V
V
G
D
A
N
F
E
D
L
S
E
Y
V
E
A
I
T
P
V
P
G
G
V
G
P
I
T
A
T
N
I
L
E
N
V
V
K
A
A
E
F
Q
K
N
N
L
------
31
PsiBlast_CBE
81.86
35%
-119
- C7 -
3NGL
1
FOLD_THEAC
C:
[3-273]
----
I
L
R
G
E
E
I
A
E
K
K
A
E
N
L
H
G
I
I
E
-----
R
-
S
-
G
-
L
E
-
P
S
L
K
L
I
Q
I
G
D
N
E
A
A
S
I
Y
A
R
A
K
I
R
R
G
K
K
I
G
I
A
V
D
-
L
E
K
Y
D
D
I
S
M
K
D
L
L
K
R
I
D
D
L
A
K
D
P
Q
I
N
G
I
M
I
E
N
P
L
--
P
--
K
--
G
F
D
Y
Y
E
I
V
R
N
I
P
Y
Y
K
D
V
D
A
L
S
P
Y
N
Q
G
-
L
-
I
A
L
N
-
R
E
-
F
L
V
P
A
T
P
R
A
V
I
D
I
M
D
Y
Y
G
Y
H
---
E
N
T
V
T
I
V
N
R
S
P
V
V
G
R
P
L
S
M
M
L
L
N
R
N
Y
T
V
S
V
C
H
S
--
K
T
K
--
D
I
G
S
M
T
R
S
S
K
I
V
V
V
A
V
G
R
P
G
F
L
N
R
E
M
V
T
P
G
S
V
V
I
D
V
G
I
N
Y
V
---
N
-------
D
---
K
V
V
G
D
A
N
F
E
D
L
S
E
Y
V
E
A
I
T
P
V
P
G
G
V
G
P
I
T
A
T
N
I
L
E
N
V
V
K
A
A
E
F
Q
K
N
N
-------