@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0087: (2015-11-28 )
MNEELLNEIPLLEDKAVFEIESASSLQDLEKVRLSYLGRKGVIKAYFDDLRKVEDTEKKRDLGAIINVLRNKLDQLIMNKESILKAEEVNFKLQNEAIDITLPVRPEKIGRAHPLSKVMNEVKLIFAHMGFRAVNGPDIEDEFHVFDALNTPSHHPAREEQDTFYLKNKINDKRMMLRTHTSSMQIRAMKKAKTFPIKIVAAGRVYRNDFDATHTPMFHQMEGLYVNENVNMGQLKFTIHHFLNKFFGDKELKIRFRNSFFPFTEPSAEVDISYKESKWIEVLGCGIVHPNVFQNVGIDHTKYSGFAFGIGIERLAMLKYQISDLRNFYDNKISWLSHYGFHFSSLR
Atome Classification :
(29 SA)
.........10........20........30........40........50........60........70........80........90.----.......100.......110.......120.......130......-.140.......150.......160......---------------------------------.170--------.----------....-....180.......----190-.......200.....-..-210........220.......230.......240......-.250....----...260.......270.-----------..-.-.--..280.......290....-------...--300..---------.......310.......320.......330.......340.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
N
E
E
L
L
N
EIPLLED
K
A
V
F
E
IESA
S
S
L
Q
D
L
E
K
V
R
L
S
YLGRK
G
V
I
K
A
Y
F
D
D
L
R
K
V
E
D
T
E
K
K
R
D
L
G
A
I
I
N
V
L
R
N
K
L
D
Q
L
I
M
N
K
E
S
ILKAE
E
V
N
F
K
----
L
QN
E
A
I
D
I
T
LPV
R
P
E
KIGRAH
P
L
S
K
V
M
N
E
V
K
L
I
F
A
H
MGFRAVNGPD-IEDE
F
H
V
F
DALNTPSHHPAREEQ
D
T
F
Y
LKN---------------------------------KI----------N----------D
K
R
M
-
M
L
R
THTSS
M
Q
I
R
A
M----KKA-KT
F
P
I
K
I
V
AAG
R
V
YR-ND-F-DATHT
P
M
F
H
QME
G
L
Y
VNENVNM
G
Q
L
K
F
T
I
H
H
F
L
N
K
FFG-DK
E
L
K
I
R
F----RNSFFPFTEPSA
E
V
D
I
S-----------YK-E-S--
K
W
I
E
V
L
GCGIVH
P
N
V
F
Q
NV-------GID--H--TK---------YS
G
F
A
F
G
I
G
I
E
R
L
A
M
L
K
Y
Q
I
S
D
L
R
N
F
Y
D
N
K
I
S
W
L
S
HYGFHFSSLR
21
PsiBlast_CBE
93.37
48%
-91
- C4 -
3PCO
2
?
C:
[15-326]
-------------------
I
S
Q
A
S
D
V
A
A
L
D
N
V
R
V
E
Y
L
G
K
K
G
H
L
T
L
Q
M
T
T
L
R
E
L
P
-
P
E
E
R
P
A
A
G
A
V
I
N
E
A
K
E
Q
V
Q
Q
A
L
N
A
R
K
A
E
L
E
S
A
A
L
N
A
R
----
L
A
A
E
T
I
D
V
S
L
P
G
R
R
I
E
N
G
G
L
H
P
V
T
R
T
I
D
R
I
E
S
F
F
G
E
L
G
F
T
V
A
T
G
P
E
-
I
E
D
D
Y
H
N
F
D
A
L
N
I
P
G
H
H
P
A
R
A
D
H
D
T
F
W
F
----------------------------------------------------------
D
T
T
R
-
L
L
R
T
Q
T
S
G
V
Q
I
R
T
M
----
K
-
A
-
Q
Q
P
P
I
R
I
I
A
P
G
R
V
Y
R
-
N
D
-
Y
-
D
Q
T
H
T
P
M
F
H
Q
M
E
G
L
I
V
D
T
N
I
S
F
T
N
L
K
G
T
L
H
D
F
L
R
N
F
F
--
E
E
D
L
Q
I
R
F
----
R
P
S
Y
F
P
F
T
E
P
S
A
E
V
D
V
M
-----------
G
K
-
N
-
G
--
K
W
L
E
V
L
G
C
G
M
V
H
P
N
V
L
R
N
V
-------
G
I
D
--
P
--
E
V
---------
Y
S
G
F
A
F
G
M
G
M
E
R
L
T
M
L
R
Y
G
V
T
D
L
R
S
F
F
E
N
D
L
R
F
L
K
Q
F
K
-------
37
Fugue
93.08
39%
-82
- C4 -
1EIY
-
SYFA_THET8
A:
[6-350]
----------------
L
A
A
I
Q
N
A
R
D
L
E
E
L
K
A
L
K
A
R
Y
L
G
K
K
G
L
L
T
Q
E
M
K
G
L
S
A
L
-
P
L
E
E
R
R
K
R
G
Q
E
L
N
A
I
K
A
A
L
E
A
A
L
E
A
R
E
K
A
L
E
E
A
A
L
K
E
A
----
L
E
R
E
R
V
D
V
S
L
P
G
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
P
E
-
V
E
S
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
G
---------------------------------
E
G
----------
F
R
L
E
G
PLG
E
E
V
E
G
R
L
-
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
----
V
A
H
-
T
P
-
P
F
R
I
V
V
P
G
R
V
F
R
-
F
E
Q
T
-
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
G
E
G
I
A
M
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
--
P
D
S
K
V
R
F
----
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
-----------
W
P
-
E
G
G
--
K
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
-------
D
A
Y
--
R
--
E
R
L
GLPPAYRG
V
T
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
K
G
V
L
----
10
PsiBlast_PDB
92.53
37%
-84
- C4 -
1EIY
-
SYFA_THET8
A:
[6-346]
----------------
L
A
A
I
Q
N
A
R
D
L
E
E
L
K
A
L
K
A
R
Y
L
G
K
K
G
L
L
T
Q
E
M
K
G
L
S
A
L
-
P
L
E
E
R
R
K
R
G
Q
E
L
N
A
I
K
A
A
L
E
A
A
L
E
A
R
E
K
A
L
E
E
A
A
L
K
E
A
----
L
E
R
E
R
V
D
V
S
L
P
G
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
P
E
-
V
E
S
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
G
---------------------------------
E
G
F
R
L
E
G
PLG
E
E
V
----------
E
G
R
L
-
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
-----
V
A
-
H
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
-
T
-
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
G
E
G
I
A
M
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
-
P
D
S
-
K
V
R
F
----
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
-----------
W
P
-
E
G
G
--
K
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
PA
Y
--
R
G
---------
V
T
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
K
G
V
L
----
13
PsiBlast_PDB
91.96
37%
-85
- C4 -
2IY5
1
SYFA_THETH
A:
[15-346]
-------------------------
L
E
E
L
K
A
L
K
A
R
Y
L
G
K
K
G
L
L
T
Q
E
M
K
G
L
S
A
L
-
P
L
E
E
R
R
K
R
G
Q
E
L
N
A
I
K
A
A
L
E
A
A
L
E
A
R
E
K
A
L
E
E
A
A
L
K
E
A
----
L
E
R
E
R
V
D
V
S
L
P
G
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
P
E
-
V
E
S
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
G
---------------------------------
E
G
F
R
L
E
G
PLG
E
E
V
----------
E
G
R
L
-
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
-----
V
A
-
H
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
-
T
-
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
G
E
G
I
A
M
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
-
P
D
S
-
K
V
R
F
----
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
-----------
W
P
-
E
G
G
--
K
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
PA
Y
--
R
G
---------
V
T
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
K
G
V
L
----
29
PsiBlast_CBE
89.40
33%
-101
- C4 -
3L4G
1
SYFA_HUMAN
K:
[222-482]
-----------------------------------------------------------------------------------------------------------------
G
H
L
H
P
L
L
K
V
R
S
Q
F
R
Q
I
F
L
E
M
G
F
T
E
M
P
T
D
N
F
I
E
S
S
F
W
N
F
D
A
L
F
Q
P
Q
Q
H
P
A
R
D
Q
H
D
T
F
F
L
R
D
PAEALQLPMDYVQRVKRTHSQGGYGSQGYKYNW
K
L
----------
D
----------
E
A
R
K
N
L
L
R
T
H
T
T
S
A
S
A
R
A
L
YRLA
Q
K
K
-
P
F
T
P
V
K
Y
F
S
I
D
R
V
F
R
-
N
E
T
L
-
D
A
T
H
L
A
E
F
H
Q
I
E
G
V
V
A
D
H
G
L
T
L
G
H
L
M
G
V
L
R
E
F
F
T
K
-
L
G
-
I
T
Q
L
--
R
F
----
K
P
A
Y
N
P
Y
T
E
P
S
M
E
V
-
F
S
-----------
Y
H
-
Q
-
G
LK
K
W
V
E
V
G
N
S
G
V
F
R
P
E
M
L
L
P
M
-------
G
L
P
--
E
--
N
----------
V
S
V
I
A
W
G
L
S
L
E
R
P
T
M
I
K
Y
G
I
N
N
I
R
E
L
V
G
H
K
V
N
L
Q
M
V
Y
D
S
P
L
C
R
L
D
8
PsiBlast_PDB
89.25
45%
-109
- C4 -
2RHS
1
SYFA_STAHJ
A:
[30-286]
-----------------------------------------------------------------------------------------
N
Q
Q
----
L
A
E
E
T
I
D
V
T
L
P
S
R
Q
I
S
I
G
S
K
H
P
L
T
R
T
V
E
E
I
E
D
L
F
L
G
L
G
Y
E
I
V
D
G
Y
E
-
V
E
Q
D
Y
Y
N
F
E
A
L
N
L
P
K
S
H
P
A
R
D
M
Q
D
S
F
Y
I
T
D
---------------------------------
E
I
--------------------------
L
M
R
T
H
T
S
P
V
Q
A
R
T
M
E
---
K
R
N
-
G
Q
G
P
V
K
I
I
C
P
G
K
V
Y
R
-
R
D
-
S
D
D
A
T
H
S
H
Q
F
T
Q
I
E
G
L
V
V
D
K
N
I
K
M
S
D
L
K
G
T
L
E
L
V
A
K
K
L
F
G
A
D
R
E
--
I
R
L
----
R
P
S
Y
F
P
F
T
E
P
S
V
E
V
D
V
S
--------------------
W
I
E
I
L
G
A
G
M
V
H
P
N
V
L
E
M
A
-------
G
F
D
--
S
--
N
E
---------
Y
S
G
F
A
F
G
M
G
P
D
R
I
A
M
L
K
Y
G
I
E
D
I
R
Y
F
Y
T
N
D
V
R
F
L
E
Q
F
K
A
V
E
D
R
G
E
2
PsiBlast_PDB
89.20
43%
-111
- C4 -
4P71
-
SYFA_PSEAE
C:
[88-337]
-------------------------------------------------------------------------------------------------
A
A
E
R
I
D
V
T
L
P
G
R
G
Q
L
S
G
G
L
H
P
V
T
R
T
L
E
R
I
E
Q
C
F
S
R
I
G
Y
E
V
A
E
G
P
E
-
V
E
D
D
Y
H
N
F
E
A
L
N
I
P
G
H
H
P
A
R
A
M
H
D
T
F
Y
F
----------------------------------------------------------
N
A
N
M
-
L
L
R
T
H
T
S
P
V
Q
V
R
T
M
----
E
S
Q
-
Q
P
-
P
I
R
I
V
C
P
G
R
V
Y
R
-
C
D
-
S
-
D
L
T
H
S
P
M
F
H
Q
V
E
G
L
L
V
D
E
G
V
S
F
A
D
L
K
G
T
I
E
E
F
L
R
A
F
F
--
E
K
Q
L
E
V
R
F
----
R
P
S
F
F
P
F
T
E
P
S
A
E
V
D
I
Q
C-------------
Q
-
T
--
G
W
L
E
V
M
G
C
G
M
V
H
P
N
V
L
R
M
S
-------
N
I
D
--
P
--
E
K
---------
F
Q
G
F
A
F
G
M
G
A
E
R
L
A
M
L
R
Y
G
V
N
D
L
R
L
F
F
D
N
D
L
R
F
L
G
Q
F
R
-------
26
PsiBlast_CBE
88.85
45%
-107
- C4 -
2RHS
2
SYFA_STAHJ
C:
[27-286]
--------------------------------------------------------------------------------------
E
K
L
N
Q
Q
----
L
A
E
E
T
I
D
V
T
L
P
S
R
Q
I
S
I
G
S
K
H
P
L
T
R
T
V
E
E
I
E
D
L
F
L
G
L
G
Y
E
I
V
D
G
Y
E
-
V
E
Q
D
Y
Y
N
F
E
A
L
N
L
P
K
S
H
P
A
R
D
M
Q
D
S
F
Y
I
T
D
---------------------------------
E
I
--------------------------
L
M
R
T
H
T
S
P
V
Q
A
R
T
M
E
---
K
R
N
-
G
Q
G
P
V
K
I
I
C
P
G
K
V
Y
R
-
R
D
-
S
D
D
A
T
H
S
H
Q
F
T
Q
I
E
G
L
V
V
D
K
N
I
K
M
S
D
L
K
G
T
L
E
L
V
A
K
K
L
F
G
A
D
R
E
--
I
R
L
----
R
P
S
Y
F
P
F
T
E
P
S
V
E
V
D
V
S
CFKCKGKGCNV
C
K
-
H
-
T
--
G
W
I
E
I
L
G
A
G
M
V
H
P
N
V
L
E
M
A
-------
G
F
D
--
S
--
N
E
---------
Y
S
G
F
A
F
G
M
G
P
D
R
I
A
M
L
K
Y
G
I
E
D
I
R
Y
F
Y
T
N
D
V
R
F
L
E
Q
F
K
A
V
E
D
R
G
E
7
PsiBlast_PDB
88.45
45%
-106
- C4 -
2RHQ
2
SYFA_STAHJ
A:
[27-286]
--------------------------------------------------------------------------------------
E
K
L
N
Q
Q
----
L
A
E
E
T
I
D
V
T
L
P
S
R
Q
I
S
I
G
S
K
H
P
L
T
R
T
V
E
E
I
E
D
L
F
L
G
L
G
Y
E
I
V
D
G
Y
E
-
V
E
Q
D
Y
Y
N
F
E
A
L
N
L
P
K
S
H
P
A
R
D
M
Q
D
S
F
Y
I
T
D
---------------------------------
E
I
--------------------------
L
M
R
T
H
T
S
P
V
Q
A
R
T
M
E
---
K
R
N
-
G
Q
G
P
V
K
I
I
C
P
G
K
V
Y
R
-
R
D
-
S
D
D
A
T
H
S
H
Q
F
T
Q
I
E
G
L
V
V
D
K
N
I
K
M
S
D
L
K
G
T
L
E
L
V
A
K
K
L
F
G
A
D
R
E
--
I
R
L
----
R
P
S
Y
F
P
F
T
E
P
S
V
E
V
D
V
S
CFKCKGKGCNV
C
K
-
H
-
T
--
G
W
I
E
I
L
G
A
G
M
V
H
P
N
V
L
E
M
A
-------
G
F
D
--
S
--
N
E
---------
Y
S
G
F
A
F
G
M
G
P
D
R
I
A
M
L
K
Y
G
I
E
D
I
R
Y
F
Y
T
N
D
V
R
F
L
E
Q
F
K
A
V
E
D
R
G
E
4
PsiBlast_PDB
88.21
43%
-109
- C4 -
4P73
1
SYFA_PSEAE
C:
[88-337]
-------------------------------------------------------------------------------------------------
A
A
E
R
I
D
V
T
L
P
G
R
G
Q
L
S
G
G
L
H
P
V
T
R
T
L
E
R
I
E
Q
C
F
S
R
I
G
Y
E
V
A
E
G
P
E
-
V
E
D
D
Y
H
N
F
E
A
L
N
I
P
G
H
H
P
A
R
A
M
H
D
T
F
Y
F
----------------------------------------------------------
N
A
N
M
-
L
L
R
T
H
T
S
P
V
Q
V
R
T
M
----
E
S
Q
-
Q
P
-
P
I
R
I
V
C
P
G
R
V
Y
R
-
C
D
-
S
-
D
L
T
H
S
P
M
F
H
Q
V
E
G
L
L
V
D
E
G
V
S
F
A
D
L
K
G
T
I
E
E
F
L
R
A
F
F
--
E
K
Q
L
E
V
R
F
----
R
P
S
F
F
P
F
T
E
P
S
A
E
V
D
I
Q
C-------------
Q
-
T
--
G
W
L
E
V
M
G
C
G
M
V
H
P
N
V
L
R
M
S
-------
N
I
D
--
P
--
E
K
---------
F
Q
G
F
A
F
G
M
G
A
E
R
L
A
M
L
R
Y
G
V
N
D
L
R
L
F
F
D
N
D
L
R
F
L
G
Q
F
R
-------
24
PsiBlast_CBE
88.01
43%
-110
- C4 -
4P73
1
SYFA_PSEAE
D:
[87-337]
------------------------------------------------------------------------------------------------
L
A
A
E
R
I
D
V
T
L
P
G
R
G
Q
L
S
G
G
L
H
P
V
T
R
T
L
E
R
I
E
Q
C
F
S
R
I
G
Y
E
V
A
E
G
P
E
-
V
E
D
D
Y
H
N
F
E
A
L
N
I
P
G
H
H
P
A
R
A
M
H
D
T
F
Y
F
----------------------------------------------------------
N
A
N
M
-
L
L
R
T
H
T
S
P
V
Q
V
R
T
M
----
E
S
Q
-
Q
P
-
P
I
R
I
V
C
P
G
R
V
Y
R
-
C
D
-
S
-
D
L
T
H
S
P
M
F
H
Q
V
E
G
L
L
V
D
E
G
V
S
F
A
D
L
K
G
T
I
E
E
F
L
R
A
F
F
--
E
K
Q
L
E
V
R
F
----
R
P
S
F
F
P
F
T
E
P
S
A
E
V
D
I
Q
CVIC----------
Q
-
T
--
G
W
L
E
V
M
G
C
G
M
V
H
P
N
V
L
R
M
S
-------
N
I
D
--
P
--
E
K
---------
F
Q
G
F
A
F
G
M
G
A
E
R
L
A
M
L
R
Y
G
V
N
D
L
R
L
F
F
D
N
D
L
R
F
L
G
Q
F
R
-------
3
PsiBlast_PDB
87.55
43%
-108
- C4 -
4P72
1
SYFA_PSEAE
C:
[90-337]
---------------------------------------------------------------------------------------------------
E
R
I
D
V
T
L
P
G
R
G
Q
L
S
G
G
L
H
P
V
T
R
T
L
E
R
I
E
Q
C
F
S
R
I
G
Y
E
V
A
E
G
P
E
-
V
E
D
D
Y
H
N
F
E
A
L
N
I
P
G
H
H
P
A
R
A
M
H
D
T
F
Y
F
----------------------------------------------------------
N
A
N
M
-
L
L
R
T
H
T
S
P
V
Q
V
R
T
M
----
E
S
Q
-
Q
P
-
P
I
R
I
V
C
P
G
R
V
Y
R
-
C
D
-
S
-
D
L
T
H
S
P
M
F
H
Q
V
E
G
L
L
V
D
E
G
V
S
F
A
D
L
K
G
T
I
E
E
F
L
R
A
F
F
--
E
K
Q
L
E
V
R
F
----
R
P
S
F
F
P
F
T
E
P
S
A
E
V
D
I
Q
C------------------
G
W
L
E
V
M
G
C
G
M
V
H
P
N
V
L
R
M
S
-------
N
I
D
--
P
--
E
K
---------
F
Q
G
F
A
F
G
M
G
A
E
R
L
A
M
L
R
Y
G
V
N
D
L
R
L
F
F
D
N
D
L
R
F
L
G
Q
F
R
-------
6
PsiBlast_PDB
87.54
43%
-108
- C4 -
4P75
1
SYFA_PSEAE
C:
[90-337]
---------------------------------------------------------------------------------------------------
E
R
I
D
V
T
L
P
G
R
G
Q
L
S
G
G
L
H
P
V
T
R
T
L
E
R
I
E
Q
C
F
S
R
I
G
Y
E
V
A
E
G
P
E
-
V
E
D
D
Y
H
N
F
E
A
L
N
I
P
G
H
H
P
A
R
A
M
H
D
T
F
Y
F
----------------------------------------------------------
N
A
N
M
-
L
L
R
T
H
T
S
P
V
Q
V
R
T
M
----
E
S
Q
-
Q
P
-
P
I
R
I
V
C
P
G
R
V
Y
R
-
C
D
-
S
-
D
L
T
H
S
P
M
F
H
Q
V
E
G
L
L
V
D
E
G
V
S
F
A
D
L
K
G
T
I
E
E
F
L
R
A
F
F
--
E
K
Q
L
E
V
R
F
----
R
P
S
F
F
P
F
T
E
P
S
A
E
V
D
I
Q
C------------------
G
W
L
E
V
M
G
C
G
M
V
H
P
N
V
L
R
M
S
-------
N
I
D
--
P
--
E
K
---------
F
Q
G
F
A
F
G
M
G
A
E
R
L
A
M
L
R
Y
G
V
N
D
L
R
L
F
F
D
N
D
L
R
F
L
G
Q
F
R
-------
5
PsiBlast_PDB
87.49
43%
-108
- C4 -
4P74
1
SYFA_PSEAE
C:
[90-337]
---------------------------------------------------------------------------------------------------
E
R
I
D
V
T
L
P
G
R
G
Q
L
S
G
G
L
H
P
V
T
R
T
L
E
R
I
E
Q
C
F
S
R
I
G
Y
E
V
A
E
G
P
E
-
V
E
D
D
Y
H
N
F
E
A
L
N
I
P
G
H
H
P
A
R
A
M
H
D
T
F
Y
F
----------------------------------------------------------
N
A
N
M
-
L
L
R
T
H
T
S
P
V
Q
V
R
T
M
----
E
S
Q
-
Q
P
-
P
I
R
I
V
C
P
G
R
V
Y
R
-
C
D
-
S
-
D
L
T
H
S
P
M
F
H
Q
V
E
G
L
L
V
D
E
G
V
S
F
A
D
L
K
G
T
I
E
E
F
L
R
A
F
F
--
E
K
Q
L
E
V
R
F
----
R
P
S
F
F
P
F
T
E
P
S
A
E
V
D
I
Q
C------------------
G
W
L
E
V
M
G
C
G
M
V
H
P
N
V
L
R
M
S
-------
N
I
D
--
P
--
E
K
---------
F
Q
G
F
A
F
G
M
G
A
E
R
L
A
M
L
R
Y
G
V
N
D
L
R
L
F
F
D
N
D
L
R
F
L
G
Q
F
R
-------
23
PsiBlast_CBE
87.35
43%
-109
- C4 -
4P74
1
SYFA_PSEAE
D:
[87-337]
------------------------------------------------------------------------------------------------
L
A
A
E
R
I
D
V
T
L
P
G
R
G
Q
L
S
G
G
L
H
P
V
T
R
T
L
E
R
I
E
Q
C
F
S
R
I
G
Y
E
V
A
E
G
P
E
-
V
E
D
D
Y
H
N
F
E
A
L
N
I
P
G
H
H
P
A
R
A
M
H
D
T
F
Y
F
----------------------------------------------------------
N
A
N
M
-
L
L
R
T
H
T
S
P
V
Q
V
R
T
M
----
E
S
Q
-
Q
P
-
P
I
R
I
V
C
P
G
R
V
Y
R
-
C
D
-
S
-
D
L
T
H
S
P
M
F
H
Q
V
E
G
L
L
V
D
E
G
V
S
F
A
D
L
K
G
T
I
E
E
F
L
R
A
F
F
--
E
K
Q
L
E
V
R
F
----
R
P
S
F
F
P
F
T
E
P
S
A
E
V
D
I
Q
CVICSGN------------
G
W
L
E
V
M
G
C
G
M
V
H
P
N
V
L
R
M
S
-------
N
I
D
--
P
--
E
K
---------
F
Q
G
F
A
F
G
M
G
A
E
R
L
A
M
L
R
Y
G
V
N
D
L
R
L
F
F
D
N
D
L
R
F
L
G
Q
F
R
-------
25
PsiBlast_CBE
87.21
43%
-109
- C4 -
4P72
1
SYFA_PSEAE
D:
[87-337]
------------------------------------------------------------------------------------------------
L
A
A
E
R
I
D
V
T
L
P
G
R
G
Q
L
S
G
G
L
H
P
V
T
R
T
L
E
R
I
E
Q
C
F
S
R
I
G
Y
E
V
A
E
G
P
E
-
V
E
D
D
Y
H
N
F
E
A
L
N
I
P
G
H
H
P
A
R
A
M
H
D
T
F
Y
F
----------------------------------------------------------
N
A
N
M
-
L
L
R
T
H
T
S
P
V
Q
V
R
T
M
----
E
S
Q
-
Q
P
-
P
I
R
I
V
C
P
G
R
V
Y
R
-
C
D
-
S
-
D
L
T
H
S
P
M
F
H
Q
V
E
G
L
L
V
D
E
G
V
S
F
A
D
L
K
G
T
I
E
E
F
L
R
A
F
F
--
E
K
Q
L
E
V
R
F
----
R
P
S
F
F
P
F
T
E
P
S
A
E
V
D
I
Q
CVICSGN------------
G
W
L
E
V
M
G
C
G
M
V
H
P
N
V
L
R
M
S
-------
N
I
D
--
P
--
E
K
---------
F
Q
G
F
A
F
G
M
G
A
E
R
L
A
M
L
R
Y
G
V
N
D
L
R
L
F
F
D
N
D
L
R
F
L
G
Q
F
R
-------
1
PsiBlast_PDB
86.95
48%
-110
- C4 -
3PCO
2
?
A:
[86-326]
-------------------------------------------------------------------------------------------
R
----
L
A
A
E
T
I
D
V
S
L
P
G
R
R
I
E
N
G
G
L
H
P
V
T
R
T
I
D
R
I
E
S
F
F
G
E
L
G
F
T
V
A
T
G
P
E
-
I
E
D
D
Y
H
N
F
D
A
L
N
I
P
G
H
H
P
A
R
A
D
H
D
T
F
W
F
----------------------------------------------------------
D
T
T
R
-
L
L
R
T
Q
T
S
G
V
Q
I
R
T
M
----
K
-
A
-
Q
Q
P
P
I
R
I
I
A
P
G
R
V
Y
R
-
N
D
-
Y
-
D
Q
T
H
T
P
M
F
H
Q
M
E
G
L
I
V
D
T
N
I
S
F
T
N
L
K
G
T
L
H
D
F
L
R
N
F
F
--
E
E
D
L
Q
I
R
F
----
R
P
S
Y
F
P
F
T
E
P
S
A
E
V
D
V
M
-----------
G
K
-
N
-
G
--
K
W
L
E
V
L
G
C
G
M
V
H
P
N
V
L
R
N
V
-------
G
I
D
--
P
--
E
V
---------
Y
S
G
F
A
F
G
M
G
M
E
R
L
T
M
L
R
Y
G
V
T
D
L
R
S
F
F
E
N
D
L
R
F
L
K
Q
F
K
-------
22
PsiBlast_CBE
86.85
43%
-109
- C4 -
4P75
1
SYFA_PSEAE
D:
[87-337]
------------------------------------------------------------------------------------------------
L
A
A
E
R
I
D
V
T
L
P
G
R
G
Q
L
S
G
G
L
H
P
V
T
R
T
L
E
R
I
E
Q
C
F
S
R
I
G
Y
E
V
A
E
G
P
E
-
V
E
D
D
Y
H
N
F
E
A
L
N
I
P
G
H
H
P
A
R
A
M
H
D
T
F
Y
F
----------------------------------------------------------
N
A
N
M
-
L
L
R
T
H
T
S
P
V
Q
V
R
T
M
----
E
S
Q
-
Q
P
-
P
I
R
I
V
C
P
G
R
V
Y
R
-
C
D
-
S
-
D
L
T
H
S
P
M
F
H
Q
V
E
G
L
L
V
D
E
G
V
S
F
A
D
L
K
G
T
I
E
E
F
L
R
A
F
F
--
E
K
Q
L
E
V
R
F
----
R
P
S
F
F
P
F
T
E
P
S
A
E
V
D
I
Q
CVICSG-------------
G
W
L
E
V
M
G
C
G
M
V
H
P
N
V
L
R
M
S
-------
N
I
D
--
P
--
E
K
---------
F
Q
G
F
A
F
G
M
G
A
E
R
L
A
M
L
R
Y
G
V
N
D
L
R
L
F
F
D
N
D
L
R
F
L
G
Q
F
R
-------
17
PsiBlast_PDB
86.56
42%
-96
- C4 -
2AKW
2
SYFA_THETH
A:
[2-262]
-----------------------------------------------------------------------------------------------------
V
D
V
S
L
P
G
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
P
E
-
V
E
S
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
G
---------------------------------
E
G
F
R
L
E
G
PLG
E
E
V
----------
E
G
R
L
-
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
-----
V
A
-
H
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
-
T
-
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
G
E
G
I
A
M
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
-
P
D
S
-
K
V
R
F
----
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
-----------
W
P
-
E
G
G
--
K
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
PA
Y
--
R
G
---------
V
T
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
K
G
V
L
----
18
PsiBlast_PDB
86.28
42%
-91
- C4 -
2ALY
2
SYFA_THETH
A:
[2-262]
-----------------------------------------------------------------------------------------------------
V
D
V
S
L
P
G
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
P
E
-
V
E
S
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
G
---------------------------------
E
G
F
R
L
E
G
PLG
E
E
V
----------
E
G
R
L
-
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
-----
V
A
-
H
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
-
T
-
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
G
E
G
I
A
M
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
-
P
D
S
-
K
V
R
F
----
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
-----------
W
P
-
E
G
G
--
K
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
PA
Y
--
R
G
---------
V
T
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
K
G
V
L
----
19
PsiBlast_PDB
85.99
42%
-98
- C4 -
2AMC
2
SYFA_THETH
A:
[2-262]
-----------------------------------------------------------------------------------------------------
V
D
V
S
L
P
G
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
P
E
-
V
E
S
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
G
---------------------------------
E
G
F
R
L
E
G
PLG
E
E
V
----------
E
G
R
L
-
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
-----
V
A
-
H
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
-
T
-
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
G
E
G
I
A
M
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
-
P
D
S
-
K
V
R
F
----
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
-----------
W
P
-
E
G
G
--
K
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
PA
Y
--
R
G
---------
V
T
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
K
G
V
L
----
48
HHSearch
85.39
39%
-103
- C4 -
1B7Y
2
SYFA_THETH
A:
[86-349]
-----------------------------------------------------------------------------------------------------
V
D
V
S
L
P
G
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
P
E
-
V
E
S
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
G
---------------------------------
E
G
F
R
L
E
G
PLG
E
E
V
----------
E
G
R
L
-
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
----
V
A
H
--
T
P
P
F
R
I
V
V
P
G
R
V
F
R
-
F
E
Q
T
-
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
G
E
G
I
A
M
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
-
P
D
-
S
K
V
R
F
----
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
-----------
W
P
E
G
-
G
--
K
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
--
P
AY
R
G
---------
V
T
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
K
G
V
L
----
16
PsiBlast_PDB
85.11
37%
-97
- C4 -
4TVA
1
SYFA_THETH
A:
[85-346]
----------------------------------------------------------------------------------------------------
R
V
D
V
S
L
P
G
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
P
E
-
V
E
S
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
G
---------------------------------
E
G
F
R
L
E
G
PLG
E
E
V
----------
E
G
R
L
-
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
-----
V
A
-
H
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
-
T
-
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
G
E
G
I
A
M
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
-
P
D
S
-
K
V
R
F
----
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
-----------
W
P
-
E
G
G
--
K
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
PA
Y
--
R
G
---------
V
T
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
K
G
V
L
----
12
PsiBlast_PDB
85.07
37%
-95
- C4 -
1JJC
2
SYFA_THET8
A:
[85-346]
----------------------------------------------------------------------------------------------------
R
V
D
V
S
L
P
G
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
P
E
-
V
E
S
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
G
---------------------------------
E
G
F
R
L
E
G
PLGE
E
V
----------
E
G
R
L
-
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
-----
V
A
-
H
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
-
T
-
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
G
E
G
I
A
M
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
-
P
D
S
-
K
V
R
F
----
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
-----------
W
P
-
E
G
G
--
K
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
PA
Y
--
R
G
---------
V
T
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
K
G
V
L
----
9
PsiBlast_PDB
84.85
37%
-99
- C4 -
1B7Y
2
SYFA_THETH
A:
[86-346]
-----------------------------------------------------------------------------------------------------
V
D
V
S
L
P
G
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
P
E
-
V
E
S
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
G
---------------------------------
E
G
F
R
L
E
G
PLG
E
E
V
----------
E
G
R
L
-
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
-----
V
A
-
H
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
-
T
-
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
G
E
G
I
A
M
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
-
P
D
S
-
K
V
R
F
----
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
-----------
W
P
-
E
G
G
--
K
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
PA
Y
--
R
G
---------
V
T
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
K
G
V
L
----
49
HHSearch
84.81
41%
-99
- C4 -
2RHQ
2
SYFA_STAHJ
A:
[25-291]
----------------------------------------------------------------------------------------
L
M
E
K
L
N
Q
Q
L
A
E
E
T
I
D
V
T
L
P
S
R
Q
I
S
I
G
S
K
H
P
L
T
R
T
V
E
E
I
E
D
L
F
L
G
L
G
Y
E
I
V
D
G
Y
E
-
V
E
Q
D
Y
Y
N
F
E
A
L
N
L
P
K
S
H
P
----
A
R
D
M
Q
D
S
F
---------------------------------
Y
I
----------
T
-----------
D
E
I
-
L
M
R
T
H
T
S
P
V
Q
A
R
T
M
----
E
K
R
N
G
Q
G
P
V
K
I
I
C
P
G
K
V
Y
R
-
R
D
S
D
-
D
A
T
H
S
H
Q
F
T
Q
I
E
G
L
V
V
D
K
N
I
K
M
S
D
L
K
G
T
L
E
L
V
A
K
K
L
F
G
-
A
D
-
R
E
I
R
L
R
P
S
Y
F
P
F
T
E
P
S
V
--
E
V
D
V
S
C
F
KCKGKGCNV--
C
K
-
H
-
T
--
G
W
I
E
I
L
G
A
G
M
V
H
P
N
V
L
E
M
A
-------
G
F
D
--
S
--
N
E
---------
Y
S
G
F
A
F
G
M
G
P
D
R
I
A
M
L
K
Y
G
I
E
D
I
R
Y
F
Y
T
N
D
V
R
F
L
E
Q
F
K
A
V
E
D
R
G
E
11
PsiBlast_PDB
84.19
37%
-92
- C4 -
1B70
2
SYFA_THETH
A:
[86-346]
-----------------------------------------------------------------------------------------------------
V
D
V
S
L
P
G
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
P
E
-
V
E
S
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
G
---------------------------------
E
G
F
R
L
E
G
PLG
E
E
V
----------
E
G
R
L
-
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
-----
V
A
-
H
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
-
T
-
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
G
E
G
I
A
M
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
-
P
D
S
-
K
V
R
F
----
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
-----------
W
P
-
E
G
G
--
K
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
PA
Y
--
R
G
---------
V
T
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
K
G
V
L
----
14
PsiBlast_PDB
83.87
37%
-95
- C4 -
3HFZ
1
SYFA_THET8
A:
[85-346]
----------------------------------------------------------------------------------------------------
R
V
D
V
S
L
P
G
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
P
E
-
V
E
S
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
G
---------------------------------
E
G
F
R
L
E
G
PLG
E
E
V
----------
E
G
R
L
-
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
-----
V
A
-
H
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
-
T
-
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
G
E
G
I
A
M
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
-
P
D
S
-
K
V
R
F
----
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
-----------
W
P
-
E
G
G
--
K
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
PA
Y
--
R
G
---------
V
T
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
K
G
V
L
----
15
PsiBlast_PDB
83.78
37%
-97
- C4 -
3TEH
1
SYFA_THETH
A:
[85-346]
----------------------------------------------------------------------------------------------------
R
V
D
V
S
L
P
G
A
S
L
F
S
G
G
L
H
P
I
T
L
M
E
R
E
L
V
E
I
F
R
A
L
G
Y
Q
A
V
E
G
P
E
-
V
E
S
E
F
F
N
F
D
A
L
N
I
P
E
H
H
P
A
R
D
M
W
D
T
F
W
L
T
G
---------------------------------
E
G
FRLEGPLG
E
E
V
----------
E
G
R
L
-
L
L
R
T
H
T
S
P
M
Q
V
R
Y
M
-----
V
A
-
H
T
P
P
F
R
I
V
V
P
G
R
V
F
R
F
E
Q
-
T
-
D
A
T
H
E
A
V
F
H
Q
L
E
G
L
V
V
G
E
G
I
A
M
A
H
L
K
G
A
I
Y
E
L
A
Q
A
L
F
G
-
P
D
S
-
K
V
R
F
----
Q
P
V
Y
F
P
F
V
E
P
G
A
Q
F
A
V
W
-----------
W
P
-
E
G
G
--
K
W
L
E
L
G
G
A
G
M
V
H
P
K
V
F
Q
A
V
D
A
Y
R
E
R
L
G
L
P
PA
Y
--
R
G
---------
V
T
G
F
A
F
G
L
G
V
E
R
L
A
M
L
R
Y
G
I
P
D
I
R
Y
F
F
G
G
R
L
K
F
L
E
Q
F
K
G
V
L
----