@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0098: (2015-11-28 )
MILRNLLFLLPPEIAHSLAIMMLKRISYRKPIELPESLSVNCFNNKFRSPVGLAAGFDKNAEVIRSMLSFGFGFIEAGTVTKHPQYGNAKPRIFRLIEDQGVINRLGFNNKGIDYFLKQISETKLDDCILGINIGKNSASKDQVSDYIDLIKMVYGKSSYIVLNISSPNTPNLRNLHNRQELSELLKSITLTRKSIDNSESVPIMLKISPDIDQQTKEDIAGLALEYKIDGLTISNTTVSRDNLHSHHNESGGLSGRPLFKLSTELLSDIYKLTQGKILLIGCGGISSGADAYKKIKAGASLVQLYTALIYHGPRAVNKINLELAELVRKDGLSNIGEAVGCDCRF
Atome Classification :
(53 SA)
-----------.........10........20-----........30..---......40.....---...50......-..60........70-........80--........90........100.......110..-------..-----...120..--------.--..--------..130.......140.......150......-.160.......170.......180.......190.....-----..200.-..-----------------....210.......220.......230.......240------.-.--....-..250.......260.......270.......280.......290.......300.......310.......320.......330.......340....-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------
M
I
L
R
N
L
L
F
LL
P
P
E
I
A
H
S
L
A
I
M
-----
M
L
K
R
ISYRKPIE---LPESL
S
V
N
CFNNK---FRSPVGLAAGF-DK
N
A
E
V
I
R
S
M
L
S
F
G
-
F
G
FIEAGTVT--KHPQYGNAK
P
R
I
F
R
L
IEDQ
G
V
I
N
RLGFNNK
G
I
D
-------
Y
F
-----
L
K
Q
I
S
ETK--------L--D
D
--------
C
I
L
G
I
NIGKNSA
S
K
D
Q
V
S
D
Y
I
D
L
I
K
M
V
YGKS-
S
Y
I
V
L
N
ISSPNTP
N
L
R
N
LH
N
R
Q
E
L
S
E
L
L
K
S
I
T
L
T
RKSID-----NSES
V
P
-
I
M
-----------------
L
K
ISPDI
D
Q
Q
T
K
E
D
I
AG
L
A
L
E
Y
K
ID
G
L
T
ISNTTVSR-------D-
N
--
L
HSH-HNESGGLSGR
P
L
F
K
L
S
T
E
L
L
S
D
I
Y
K
LTQG
K
I
L
L
I
GCGGISS
G
A
D
A
Y
K
K
I
K
A
G
A
S
L
V
Q
L
Y
T
A
L
I
YHGPRA
V
N
K
I
N
L
E
L
A
E
L
V
R
KDG
L
S
N
I
G
E
AVGCDCRF-
2
PsiBlast_PDB
94.47
44%
-91
- C3 -
1UUO
4
PYRD_RAT
A:
[18-371]
------------
L
M
P
G
L
Q
R
L
L
D
P
E
S
A
H
R
L
A
V
R
V
T
S
L
G
L
L
P
----
Q
D
S
-------
D
M
L
E
V
K
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
N
G
E
A
V
D
G
L
Y
K
L
G
-
F
G
F
V
E
V
G
S
V
T
--
P
Q
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
Q
--------
L
T
A
D
G
--------
L
P
L
G
I
N
L
G
K
N
K
T
S
E
D
A
A
A
D
Y
A
E
G
V
R
T
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
--------
Q
G
K
T
E
L
R
H
L
L
S
K
V
L
Q
E
R
D
A
L
K
-----
G
T
R
K
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
A
Q
D
K
E
D
I
A
S
V
A
R
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
V
G
--
L
Q
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
I
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
Q
A
G
A
S
L
V
Q
L
Y
T
A
L
I
F
L
G
P
P
V
V
V
R
V
K
R
E
L
E
A
L
L
K
E
R
G
F
T
T
V
T
D
A
I
G
A
D
H
R
R
-
21
PsiBlast_CBE
94.44
44%
-91
- C3 -
1UUM
4
PYRD_RAT
B:
[18-371]
------------
L
M
P
G
L
Q
R
L
L
D
P
E
S
A
H
R
L
A
V
R
VTSLG
L
L
P
R
A
T
F
Q
D
S
-------
D
M
L
E
V
K
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
N
G
E
A
V
D
G
L
Y
K
L
G
-
F
G
F
V
E
V
G
S
V
T
--
P
Q
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
EHRLR
A
R
Q
Q
K
Q
A
Q
--------
L
TA
D
G
--------
L
P
L
G
I
N
L
G
K
N
K
T
S
E
D
A
A
A
D
Y
A
E
G
V
R
T
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
---------
Q
G
K
T
E
L
R
H
L
L
S
K
V
L
Q
E
R
D
A
L
K
-----
G
T
R
K
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
A
Q
D
K
E
D
I
A
S
V
A
R
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
V
G
--
L
Q
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
I
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
Q
A
G
A
S
L
V
Q
L
Y
T
A
L
I
F
L
G
P
P
V
V
V
R
V
K
R
E
L
E
A
L
L
K
E
R
G
F
T
T
V
T
D
A
I
G
A
D
H
R
R
-
1
PsiBlast_PDB
93.96
44%
-91
- C3 -
1UUM
4
PYRD_RAT
A:
[18-371]
------------
L
M
P
G
L
Q
R
L
L
D
P
E
S
A
H
R
L
A
V
R
V
T
S
L
G
L
L
P
R
A
T
F
Q
D
S
-------
D
M
L
E
V
K
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
N
G
E
A
V
D
G
L
Y
K
L
G
-
F
G
F
V
E
V
G
S
V
T
--
P
Q
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
Q
--------
L
T
A
D
G
--------
L
P
L
G
I
N
L
G
K
N
K
T
S
E
D
A
A
A
D
Y
A
E
G
V
R
T
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
---------
Q
G
K
T
E
L
R
H
L
L
S
K
V
L
Q
E
R
D
A
L
K
-----
G
T
R
K
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
A
Q
D
K
E
D
I
A
S
V
A
R
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
V
G
--
L
Q
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
I
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
Q
A
G
A
S
L
V
Q
L
Y
T
A
L
I
F
L
G
P
P
V
V
V
R
V
K
R
E
L
E
A
L
L
K
E
R
G
F
T
T
V
T
D
A
I
G
A
D
H
R
R
-
3
PsiBlast_PDB
93.37
44%
-86
- C3 -
4ORI
3
PYRD_RAT
A:
[10-363]
------------
L
M
P
G
L
Q
R
L
L
D
P
E
S
A
H
R
L
A
V
R
V
T
S
L
G
L
L
P
R
A
T
F
Q
D
S
-------
D
M
L
E
V
K
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
N
G
E
A
V
D
G
L
Y
K
L
G
-
F
G
F
V
E
V
G
S
V
T
--
P
Q
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
Q
--------
L
T
A
D
G
--------
L
P
L
G
I
N
L
G
K
N
K
T
S
E
D
A
A
A
D
Y
A
E
G
V
R
T
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
------
Q
G
K
T
E
L
R
H
L
L
S
K
V
L
Q
E
R
D
A
L
K
-----
G
T
R
K
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
A
Q
D
K
E
D
I
A
S
V
A
R
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
V
G
--
L
Q
G
A
L
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
I
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
Q
A
G
A
S
L
V
Q
L
Y
T
A
L
I
F
L
G
P
P
V
V
V
R
V
K
R
E
L
E
A
L
L
K
E
R
G
F
T
T
V
T
D
A
I
G
A
D
H
R
R
-
25
PsiBlast_CBE
93.26
43%
-84
- C3 -
3G0U
3
PYRD_HUMAN
A:
[13-366]
------------
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
---
F
Q
D
S
-------
D
M
L
E
V
R
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
K
--------
L
T
E
D
G
--------
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
-----
R
V
H
R
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
-
A
GL
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
-
31
PsiBlast_CBE
92.90
43%
-91
- C3 -
2PRH
4
PYRD_HUMAN
A:
[13-366]
------------
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
Q
D
S
-------
D
M
L
E
V
R
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
K
--------
L
T
E
D
G
--------
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
---------
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
-----
R
V
H
R
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
-
A
GL
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
-
13
PsiBlast_PDB
92.55
43%
-84
- C3 -
4JTS
11
PYRD_HUMAN
A:
[36-389]
------------
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
Q
D
S
-------
D
M
L
E
V
R
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
K
--------
L
T
E
D
G
--------
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
-----
R
V
H
R
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
-
A
GL
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
-
5
PsiBlast_PDB
92.51
43%
-85
- C3 -
3U2O
7
PYRD_HUMAN
A:
[41-394]
------------
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
Q
D
S
-------
D
M
L
E
V
R
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
K
--------
L
T
E
D
G
--------
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
-----
R
V
H
R
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
-
A
GL
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
--
15
PsiBlast_PDB
92.44
43%
-86
- C3 -
4JTU
7
PYRD_HUMAN
A:
[36-389]
------------
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
Q
D
S
-------
D
M
L
E
V
R
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
K
--------
L
T
E
D
G
--------
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
-----
R
V
H
R
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
-
A
GL
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
-
24
PsiBlast_CBE
92.33
43%
-84
- C3 -
3G0X
4
PYRD_HUMAN
A:
[13-366]
------------
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
---
F
Q
D
S
-------
D
M
L
E
V
R
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
K
--------
L
T
E
D
G
--------
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
-----
R
V
H
R
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
-
A
GL
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
-
4
PsiBlast_PDB
92.23
43%
-94
- C3 -
4OQV
9
PYRD_HUMAN
A:
[10-363]
------------
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
Q
D
S
-------
D
M
L
E
V
R
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
K
--------
L
T
E
D
G
--------
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
---------
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
-----
R
V
H
R
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
-
A
GL
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
--
16
PsiBlast_PDB
92.21
43%
-85
- C3 -
4LS0
13
PYRD_HUMAN
A:
[36-389]
------------
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
Q
D
S
-------
D
M
L
E
V
R
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
K
--------
L
T
E
D
G
--------
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
-----
R
V
H
R
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
-
A
GL
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
-
10
PsiBlast_PDB
92.21
43%
-86
- C3 -
4JGD
12
PYRD_HUMAN
A:
[36-389]
------------
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
Q
D
S
-------
D
M
L
E
V
R
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
K
--------
L
T
E
D
G
--------
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
-----
R
V
H
R
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
-
A
GL
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
-
38
PsiBlast_CBE
92.12
43%
-83
- C3 -
2FPT
8
PYRD_HUMAN
A:
[41-394]
------------
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
---
F
Q
D
S
-------
D
M
L
E
V
R
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
K
--------
L
T
E
D
G
--------
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
-----
R
V
H
R
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
-
A
GL
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
-
27
PsiBlast_CBE
92.12
43%
-83
- C3 -
3FJ6
6
PYRD_HUMAN
A:
[13-366]
------------
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
---
F
Q
D
S
-------
D
M
L
E
V
R
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
K
--------
L
T
E
D
G
--------
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
-----
R
V
H
R
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
-
A
GL
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
-
14
PsiBlast_PDB
92.12
43%
-84
- C3 -
4JTT
11
PYRD_HUMAN
A:
[36-389]
------------
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
Q
D
S
-------
D
M
L
E
V
R
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
K
--------
L
T
E
D
G
--------
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
-----
R
V
H
R
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
-
A
GL
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
-
6
PsiBlast_PDB
92.08
43%
-87
- C3 -
3KVJ
6
PYRD_HUMAN
A:
[36-389]
------------
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
Q
D
S
-------
D
M
L
E
V
R
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
K
--------
L
T
E
D
G
--------
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
-----
R
V
H
R
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
-
A
GL
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
-
33
PsiBlast_CBE
92.00
43%
-83
- C3 -
1D3H
5
PYRD_HUMAN
A:
[13-366]
------------
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
---
F
Q
D
S
-------
D
M
L
E
V
R
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
K
--------
L
T
E
D
G
--------
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
-----
R
V
H
R
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
-
A
GL
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
-
17
PsiBlast_PDB
91.94
43%
-83
- C3 -
4LS1
8
PYRD_HUMAN
A:
[36-389]
------------
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
Q
D
S
-------
D
M
L
E
V
R
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
K
--------
L
T
E
D
G
--------
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
-----
R
V
H
R
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
-
A
GL
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
-
35
PsiBlast_CBE
91.89
43%
-85
- C3 -
2FQI
8
PYRD_HUMAN
A:
[41-394]
------------
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
-
F
Q
D
S
-------
D
M
L
E
V
R
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
K
--------
L
T
E
D
G
--------
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
-----
R
V
H
R
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
-
A
GL
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
-
8
PsiBlast_PDB
91.89
43%
-83
- C3 -
3KVL
6
PYRD_HUMAN
A:
[36-389]
------------
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
Q
D
S
-------
D
M
L
E
V
R
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
K
--------
L
T
E
D
G
--------
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
-----
R
V
H
R
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
-
A
GL
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
--
75
Fugue
91.84
43%
-91
- C3 -
1D3G
6
PYRD_HUMAN
A:
[1-367]
MATGD
E
R
F
Y
A
E
H
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
-----
F
T
S
--
L
G
L
L
P
F
Q
---
D
S
D
M
L
E
V
R
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
-F
D
K
H
G
E
A
V
D
G
L
Y
K
M
-G
F
G
F
V
E
I
G
S
V
T
PK--
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
-----
E
-
H
R
L
R
A
R
--------
Q
--
Q
K
Q
A
K
L
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
-A
D
Y
L
V
V
N
V
S
S
P
N
T
A
----
G
L
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
-----
R
V
H
R
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
-
S
RPAGLQG
A
-------
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
-R
7
PsiBlast_PDB
91.77
43%
-85
- C3 -
3KVK
5
PYRD_HUMAN
A:
[36-389]
------------
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
Q
D
S
-------
D
M
L
E
V
R
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
K
--------
L
T
E
D
G
--------
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
-----
R
V
H
R
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
-
A
GL
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
-
9
PsiBlast_PDB
91.68
43%
-83
- C3 -
3KVM
6
PYRD_HUMAN
A:
[36-389]
------------
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
Q
D
S
-------
D
M
L
E
V
R
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
K
--------
L
T
E
D
G
--------
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
-----
R
V
H
R
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
-
A
GL
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
-
18
PsiBlast_PDB
91.62
43%
-81
- C3 -
4LS2
8
PYRD_HUMAN
A:
[36-389]
------------
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
Q
D
S
-------
D
M
L
E
V
R
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
K
--------
L
T
E
D
G
--------
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
-----
R
V
H
R
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
-
A
GL
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
-
26
PsiBlast_CBE
91.58
43%
-83
- C3 -
3FJL
6
PYRD_HUMAN
A:
[13-366]
------------
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
---
F
Q
D
S
-------
D
M
L
E
V
R
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
K
--------
L
T
E
D
G
--------
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
-----
R
V
H
R
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
-
A
GL
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
-
11
PsiBlast_PDB
91.58
43%
-81
- C3 -
3W7R
28
PYRD_HUMAN
A:
[36-389]
------------
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
Q
D
S
-------
D
M
L
E
V
R
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
K
--------
L
T
E
D
G
--------
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
-----
R
V
H
R
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
-
A
GL
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
-
22
PsiBlast_CBE
91.53
43%
-84
- C3 -
3ZWT
8
PYRD_HUMAN
A:
[13-366]
------------
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
---
R
F
Q
D
S
-------
D
M
L
E
V
R
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
K
--------
L
T
E
D
G
--------
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
-----
R
V
H
R
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
-
A
GL
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
-
19
PsiBlast_PDB
91.53
43%
-81
- C3 -
2B0M
3
PYRD_HUMAN
A:
[39-392]
------------
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
---
F
Q
D
S
-------
D
M
L
E
V
R
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
K
--------
L
T
E
D
G
--------
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
-----
R
V
H
R
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
-
A
GL
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
-
37
PsiBlast_CBE
91.41
43%
-83
- C3 -
2FPV
9
PYRD_HUMAN
A:
[41-394]
------------
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
Q
D
S
-------
D
M
L
E
V
R
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
K
--------
L
T
E
D
G
--------
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
-----
R
V
H
R
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
-
A
GL
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
-
28
PsiBlast_CBE
91.39
43%
-81
- C3 -
3F1Q
6
PYRD_HUMAN
A:
[13-366]
------------
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
---
F
Q
D
S
-------
D
M
L
E
V
R
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
K
--------
L
T
E
D
G
--------
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
-----
R
V
H
R
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
-
A
GL
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
-
12
PsiBlast_PDB
91.39
43%
-84
- C3 -
4JS3
14
PYRD_HUMAN
A:
[36-389]
------------
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
Q
D
S
-------
D
M
L
E
V
R
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
K
--------
L
T
E
D
G
--------
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
-----
R
V
H
R
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
-
A
GL
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
-
29
PsiBlast_CBE
91.37
43%
-81
- C3 -
2PRM
2
PYRD_HUMAN
A:
[13-366]
------------
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
Q
D
S
-------
D
M
L
E
V
R
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
K
--------
L
T
E
D
G
--------
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
-----
R
V
H
R
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
-
A
GL
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
-
30
PsiBlast_CBE
91.33
43%
-83
- C3 -
2PRL
7
PYRD_HUMAN
A:
[13-366]
------------
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
Q
D
S
-------
D
M
L
E
V
R
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
K
--------
L
T
E
D
G
--------
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
-----
R
V
H
R
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
-
A
GL
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
-
36
PsiBlast_CBE
91.06
43%
-84
- C3 -
2FPY
9
PYRD_HUMAN
A:
[41-394]
------------
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
Q
D
S
-------
D
M
L
E
V
R
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
K
--------
L
T
E
D
G
--------
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
-----
R
V
H
R
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
-
A
GL
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
-
20
PsiBlast_PDB
91.02
43%
-84
- C3 -
1D3G
6
PYRD_HUMAN
A:
[13-366]
------------
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
---
F
Q
D
S
-------
D
M
L
E
V
R
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
K
--------
L
T
E
D
G
--------
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
----
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
-----
R
V
H
R
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
-
A
GL
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
-
32
PsiBlast_CBE
90.77
43%
-83
- C3 -
2BXV
5
PYRD_HUMAN
A:
[13-366]
------------
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
---
F
Q
D
S
-------
D
M
L
E
V
R
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
K
--------
L
T
E
D
G
--------
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
----
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
-----
R
V
H
R
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
-
A
GL
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
-
23
PsiBlast_CBE
90.56
43%
-85
- C3 -
3ZWS
8
PYRD_HUMAN
A:
[13-366]
------------
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
--
A
R
F
Q
D
S
-------
D
M
L
E
V
R
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
K
--------
L
T
E
D
G
--------
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
-----
R
V
H
R
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
-
A
GL
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
-
34
PsiBlast_CBE
90.19
43%
-80
- C3 -
2WV8
6
PYRD_HUMAN
A:
[11-364]
------------
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
Q
D
S
-------
D
M
L
E
V
R
V
L
G
H
K
---
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
--
P
K
P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
-------
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
K
--------
L
T
E
D
G
--------
L
P
L
G
V
N
L
G
K
N
K
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
-----
R
V
H
R
P
A
-
V
L
-----------------
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
-------
P
-
A
GL
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
-
51
PsiBlast_CBE
90.00
38%
-88
- C3 -
3I65
4
PYRD_PLAF7
A:
[46-409]
-----------
I
F
L
K
F
C
L
K
Y
I
D
G
E
I
C
H
D
L
F
L
L
-----
L
G
K
Y
N
I
L
--
P
Y
D
---
T
S
N
D
S
I
Y
A
C
T
N
I
K
HLD
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
--
P
R
G
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
E
N
L
I
L
F
-----
R
K
R
Q
E
E
D
K
--------
L
L-
S
K
--------
H
I
V
G
V
S
I
G
K
N
K
D
T
V
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
-
D
Y
I
A
I
N
V
S
S
P
N
-----------
E
A
G
K
L
K
N
I
I
L
S
V
K
E
E
I
D
-----
N
L
E
K
N
N
-
I
M
N
D
E
F
L
W
FNTTKKK
P
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
-------
N
-
D
--
I
K
S
F
-
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
H
S
--
39
PsiBlast_CBE
89.46
38%
-87
- C3 -
3SFK
3
PYRD_PLAF7
A:
[31-394]
-----------
I
F
L
K
F
C
L
K
Y
I
D
G
E
I
C
H
D
L
F
L
L
-----
L
G
K
Y
N
I
L
--
P
Y
D
---
T
S
N
D
S
I
Y
A
C
T
N
I
K
HLD
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
--
P
R
G
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
E
N
L
I
L
F
-----
R
K
R
Q
E
E
D
K
--------
L
L-
S
K
--------
H
I
V
G
V
S
I
G
K
N
K
D
T
V
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
-
D
Y
I
A
I
N
V
S
S
P
----------
N
Q
E
A
G
K
L
K
N
I
I
L
S
V
K
E
E
I
D
-----
N
L
E
K
N
N
-
I
M
N
D
E
F
L
W
FNTTKK
K
P
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
-------
N
-
D
--
I
K
S
F
-
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
----
44
PsiBlast_CBE
88.87
38%
-78
- C3 -
4CQ9
3
PYRD_PLAF7
A:
[32-395]
-----------
I
F
L
K
F
C
L
K
Y
I
D
G
E
I
C
H
D
L
F
L
L
-----
L
G
K
Y
N
I
L
--
P
Y
D
---
T
S
N
D
S
I
Y
A
C
T
N
I
K
HLD
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
--
P
R
G
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
E
N
L
I
L
F
-----
R
K
R
Q
E
E
D
K
--------
L
L-
S
K
--------
H
I
V
G
V
S
I
G
K
N
K
D
T
V
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
-
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
---
N
Q
E
A
G
K
L
K
N
I
I
L
S
V
K
E
E
I
D
-----
N
L
E
K
N
N
---FLWFNTTKK
K
P
L
V
F
---
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
-------
N
-
D
--
I
K
S
F
-
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
H
S
--
43
PsiBlast_CBE
88.31
38%
-78
- C3 -
4CQ9
3
PYRD_PLAF7
B:
[32-395]
-----------
I
F
L
K
F
C
L
K
Y
I
D
G
E
I
C
H
D
L
F
L
L
-----
L
G
K
Y
N
I
L
--
P
Y
D
---
T
S
N
D
S
I
Y
A
C
T
N
I
K
HLD
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
--
P
R
G
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
S
I
I
N
S
C
G
F
N
N
M
G
C
D
KVTENLI
L
F
-----
R
K
R
Q
E
E
D
K
--------
L
L-
S
K
--------
H
I
V
G
V
S
I
G
K
N
K
D
T
V
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
-
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
---
N
Q
E
A
G
K
L
K
N
I
I
L
S
V
K
E
E
I
D
-----
N
L
E
K
N
N
---FLWFNTTKKKPLVF---
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
-------
N
-
D
--
I
K
S
F
-
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
H
S
--
53
HHSearch
88.17
38%
-79
* C3 *
1TV5
6
PYRD_PLAF7
A:
[45-440]
------------
F
L
K
F
C
L
K
Y
I
D
G
E
I
C
H
D
L
F
L
L
-----
L
G
K
Y
N
--
I
L
P
Y
D
TSN
D
S
I
Y
A
C
T
N
I
K
H
L
D
---
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
--
P
R
G
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
S
I
I
N
S
C
G
F
N
N
M
G
C
D
-------
K
V
-----
T
E
N
L
I
L
F
R
K
R
Q
E
E
D
KL
L
--
S
K
--------
H
I
V
G
V
S
I
G
K
N
K
D
T
V
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
-
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
N
Q
E
A
G
K
L
K
N
I
I
L
S
V
K
E
E
I
D
N
L
E
FLWFN
T
T
K
K
K
P
L
V
F
-----------------
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
-------
N
-
D
--
I
K
S
F
-
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
H
---
46
PsiBlast_CBE
88.13
38%
-78
- C3 -
4CQ8
3
PYRD_PLAF7
A:
[32-395]
-----------
I
F
L
K
F
C
L
K
Y
I
D
G
E
I
C
H
D
L
F
L
L
-----
L
G
K
Y
N
I
L
--
P
Y
D
---
T
S
N
D
S
I
Y
A
C
T
N
I
K
HLD
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
--
P
R
G
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
E
N
L
I
L
F
-----
R
K
R
Q
E
E
D
K
--------
L
L-
S
K
--------
H
I
V
G
V
S
I
G
K
N
K
D
T
V
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
-
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
---
N
Q
E
A
G
K
L
K
N
I
I
L
S
V
K
E
E
I
D
-----
N
L
E
K
N
N
---FLWFNTTKKK
P
L
V
F
---
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
-------
N
-
D
--
I
K
S
F
-
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
H
S
--
42
PsiBlast_CBE
87.80
38%
-80
- C3 -
4CQA
3
PYRD_PLAF7
A:
[32-395]
-----------
I
F
L
K
F
C
L
K
Y
I
D
G
E
I
C
H
D
L
F
L
L
-----
L
G
K
Y
N
I
L
--
P
Y
D
---
T
S
N
D
S
I
Y
A
C
T
N
I
K
HLD
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
--
P
R
G
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
E
N
L
I
L
F
-----
R
K
R
Q
E
E
D
K
--------
L
L-
S
K
--------
H
I
V
G
V
S
I
G
K
N
K
D
T
V
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
-
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
---
N
Q
E
A
G
K
L
K
N
I
I
L
S
V
K
E
E
I
D
-----
N
L
E
K
N
N
-
I
M
NFLWFNTTKK
K
P
L
V
F
--
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
-------
N
-
D
--
I
K
S
F
-
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
H
S
--
48
PsiBlast_CBE
87.69
38%
-78
- C3 -
3O8A
4
PYRD_PLAF7
A:
[46-409]
-----------
I
F
L
K
F
C
L
K
Y
I
D
G
E
I
C
H
D
L
F
L
L
-----
L
G
K
Y
N
I
L
--
P
Y
D
---
T
S
N
D
S
I
Y
A
C
T
N
I
K
HLD
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
--
P
R
G
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
E
N
L
I
L
F
-----
R
K
R
Q
E
E
D
K
--------
L
L-
S
K
--------
H
I
V
G
V
S
I
G
K
N
K
D
T
V
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
-
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
---
N
Q
E
A
G
K
L
K
N
I
I
L
S
V
K
E
E
I
D
-----
N
L
E
K
N
N
-
I
M
N
D
E
F
L
W
FNTTKKK
P
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
-------
N
-
D
--
I
K
S
F
-
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
----
45
PsiBlast_CBE
87.60
38%
-77
- C3 -
4CQ8
3
PYRD_PLAF7
B:
[32-395]
-----------
I
F
L
K
F
C
L
K
Y
I
D
G
E
I
C
H
D
L
F
L
L
-----
L
G
K
Y
N
I
L
--
P
Y
D
---
T
S
N
D
S
I
Y
A
C
T
N
I
K
HLD
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
--
P
R
G
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
S
I
I
N
S
C
G
F
N
N
M
G
C
D
KVTENLI
L
F
-----
R
K
R
Q
E
E
D
K
--------
L
L-
S
K
--------
H
I
V
G
V
S
I
G
K
N
K
D
T
V
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
-
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
---
N
Q
E
A
G
K
L
K
N
I
I
L
S
V
K
E
E
I
D
-----
N
L
E
K
N
N
---FLWFNTTKKKPLVF---
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
-------
N
-
D
--
I
K
S
F
-
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
H
S
--
41
PsiBlast_CBE
87.48
38%
-80
- C3 -
4CQA
3
PYRD_PLAF7
B:
[32-395]
-----------
I
F
L
K
F
C
L
K
Y
I
D
G
E
I
C
H
D
L
F
L
L
-----
L
G
K
Y
N
I
L
--
P
Y
D
---
T
S
N
D
S
I
Y
A
C
T
N
I
K
HLD
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
--
P
R
G
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
E
N
L
I
L
F
-----
R
K
R
Q
E
E
D
K
--------
L
L-
S
K
--------
H
I
V
G
V
S
I
G
K
N
K
D
T
V
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
-
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
---
N
Q
E
A
G
K
L
K
N
I
I
L
S
V
K
E
E
I
D
-----
N
L
E
K
N
N
---FLWFNTTKK
K
P
L
V
F
---
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
-------
N
-
D
--
I
K
S
F
-
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
H
S
--
40
PsiBlast_CBE
86.87
38%
-80
- C3 -
4ORM
5
PYRD_PLAF7
A:
[32-395]
-----------
I
F
L
K
F
C
L
K
Y
I
D
G
E
I
C
H
D
L
F
L
L
-----
L
G
K
Y
N
I
L
--
P
Y
D
---
T
S
N
D
S
I
Y
A
C
T
N
I
K
HLD
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
--
P
R
G
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
E
N
L
I
L
F
-----
R
K
R
Q
E
E
D
K
--------
L
L-
S
K
--------
H
I
V
G
V
S
I
G
K
N
K
D
T
V
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
-
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
---
N
Q
E
A
G
K
L
K
N
I
I
L
S
V
K
E
E
I
D
-----
N
L
E
K
N
N
-
I
M
N
D
E
F
L
W
FNTTKKK
P
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
-------
N
-
D
--
I
K
S
F
-
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
----
49
PsiBlast_CBE
86.06
38%
-80
- C3 -
3I6R
3
PYRD_PLAF7
A:
[46-409]
-----------
I
F
L
K
F
C
L
K
Y
I
D
G
E
I
C
H
D
L
F
L
L
-----
L
G
K
Y
N
I
L
--
P
Y
D
---
T
S
N
D
S
I
Y
A
C
T
N
I
K
HLD
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
--
P
R
G
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
E
N
L
I
L
F
-----
R
K
R
Q
E
E
D
K
--------
L
L-
S
K
--------
H
I
V
G
V
S
I
G
K
N
K
D
T
V
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
-
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
---
N
Q
E
A
G
K
L
K
N
I
I
L
S
V
K
E
E
I
D
-----
N
L
E
K
N
N
-
I
M
N
D
E
F
L
W
FNTTKK
K
P
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
-------
N
-
D
--
I
K
S
F
-
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
H
---
52
PsiBlast_CBE
85.76
35%
-76
- C3 -
1TV5
6
PYRD_PLAF7
A:
[44-437]
-----------
I
F
L
K
F
C
L
K
Y
I
D
G
E
I
C
H
D
L
F
L
L
-----
L
G
K
Y
N
I
L
--
P
Y
D
---
T
S
N
D
S
I
Y
A
C
T
N
I
K
HLD
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
--
P
R
G
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
E
N
L
I
L
F
-----
R
K
R
Q
E
E
D
K
L-------
L
--
S
K
--------
H
I
V
G
V
S
I
G
K
N
K
D
T
V
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
-
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
---
D
N
Q
E
A
G
K
L
K
N
I
I
L
S
V
K
E
E
I
D
-----
N
L
E
------FLWFNTTKKK
P
L
V
F
---
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
-------
N
-
D
--
I
K
S
F
-
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
H
---
50
PsiBlast_CBE
85.58
38%
-79
- C3 -
3I68
3
PYRD_PLAF7
A:
[46-409]
-----------
I
F
L
K
F
C
L
K
Y
I
D
G
E
I
C
H
D
L
F
L
L
-----
L
G
K
Y
N
I
L
--
P
Y
D
---
T
S
N
D
S
I
Y
A
C
T
N
I
K
HLD
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
--
P
R
G
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
E
N
L
I
L
F
-----
R
K
R
Q
E
E
D
K
--------
L
L-
S
K
--------
H
I
V
G
V
S
I
G
K
N
K
D
T
V
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
-
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
---
N
Q
E
A
G
K
L
K
N
I
I
L
S
V
K
E
E
I
D
-----
N
L
E
K
N
N
-
I
M
N
D
E
F
L
W
FNTTKK
K
P
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
-------
N
-
D
--
I
K
S
F
-
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
H
---