@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0114: (2015-11-28 )
MPKLSIVVAPDERLTTRASEVTGINDKIKELVNDMFETMYNAEGLGLAAVQIGVLKRIFVMDIQLEDIKGEPVGYESTGKFCMINPEITELSDEQVILKEGCLSIPEQSHEIRRPKYLTVKYKDLNNKEQTLKASGWLARCIQHELDHLNGILYIRHLSKLKYDMAMKKAEKFKRHYER
Atome Classification :
(76 SA)
.........10........20..---.-----.....30........40..-......50........60..------......70-.....-...80........90..-----......100.......110.......120.......130.......140.......150...-....160--.......170.......-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MP
K
L
S
I
V
VAPDERLTTRASEVTG---
I
-----
N
D
K
I
K
E
L
V
N
D
M
F
E
T
M
YNAE-GL
G
L
A
A
V
Q
I
G
V
L
K
R
I
F
V
M
D
I
------
Q
L
EDIKGE-PVGYE-STG
K
F
C
M
INPEITELSD-----E
Q
V
I
L
K
E
G
C
LSIPEQSHEIRRP
K
Y
L
T
V
K
Y
KDLNN
K
E
Q
T
L
K
A
S
G
W
L
A
R
C
I
Q
H
E
L
D
HL
N
G
I
L
Y
I
-
R
H
L
S
K
L
K
--
Y
D
M
A
M
K
K
A
E
K
F
K
R
H
YER-
21
PsiBlast_CBE
97.23
48%
-100
- C7 -
3OCA
2
?
B:
[23-205]
-
S
V
L
S
I
V
T
V
P
D
K
R
L
S
L
C
S
E
E
V
E
K
---
V
-----
D
Q
S
I
R
K
L
V
D
D
M
F
E
T
M
H
A
N
Q
-
G
L
G
L
A
A
V
Q
V
G
V
H
K
R
I
L
V
M
N
V
PEEFED------
D
K
-
I
E
G
Y
E
L
Y
G
G
P
Y
C
I
I
N
P
K
I
V
D
I
S
Q
-----
E
K
V
K
L
K
E
G
C
L
S
V
P
G
Y
F
D
Y
I
V
R
P
Q
R
I
A
V
Q
Y
L
D
Y
N
G
N
E
C
I
I
K
A
Q
G
W
L
A
R
C
L
Q
H
E
I
D
H
L
N
G
T
V
F
L
-
K
Y
L
S
K
F
K
--
R
D
F
A
I
E
K
V
K
K
K
E
R
T
D
L
I
-
1
PsiBlast_PDB
96.99
48%
-107
- C7 -
3U04
4
?
A:
[3-186]
M
S
V
L
S
I
V
T
V
P
D
K
R
L
S
L
C
S
E
E
V
E
K
---
V
-----
D
Q
S
I
R
K
L
V
D
D
M
F
E
T
M
H
A
N
Q
-
G
L
G
L
A
A
V
Q
V
G
V
H
K
R
I
L
V
M
N
V
P
EE------------
I
E
G
Y
E
L
Y
G
G
P
Y
C
I
I
N
P
K
I
V
D
I
S
Q
-----
E
K
V
K
L
K
E
G
C
L
S
V
P
G
Y
F
D
Y
I
V
R
P
Q
R
I
A
V
Q
Y
L
D
Y
N
G
N
E
C
I
I
K
A
Q
G
W
L
A
R
C
L
Q
H
E
I
D
H
L
N
G
T
V
F
L
-
K
Y
L
S
K
F
K
--
R
D
F
A
I
E
K
V
K
K
K
E
R
T
----
101
HHSearch
96.12
49%
-107
- C7 -
3U04
4
?
A:
[3-187]
M
S
V
L
S
I
V
T
V
P
D
K
R
L
S
L
C
S
E
E
V
E
K
---
V
-----
D
Q
S
I
R
K
L
V
D
D
M
F
E
T
M
H
A
N
Q
-
G
L
G
L
A
A
V
Q
V
G
V
H
K
R
I
L
V
M
N
V
------
P
E
E
-----I
E
G
Y
E
L
-
Y
G
G
P
Y
C
I
I
N
P
K
I
V
D
I
S
Q
-----
E
K
V
K
L
K
E
G
C
L
S
V
P
G
Y
F
D
Y
I
V
R
P
Q
R
I
A
V
Q
Y
L
D
Y
N
G
N
E
C
I
I
K
A
Q
G
W
L
A
R
C
L
Q
H
E
I
D
H
L
N
G
T
V
F
L
-
K
Y
L
S
K
F
K
--
R
D
F
A
I
E
K
V
K
K
K
E
R
T
----
2
PsiBlast_PDB
95.30
48%
-98
- C7 -
3OCA
2
?
A:
[23-205]
-
S
V
L
S
I
V
T
V
P
D
K
R
L
S
L
C
S
E
E
V
E
K
---
V
-----
D
Q
S
I
R
K
L
V
D
D
M
F
E
T
M
H
A
N
Q
-
G
L
G
L
A
A
V
Q
V
G
V
H
K
R
I
L
V
M
N
V
P
EE------
N
V
E
D
K
-
I
E
G
Y
E
L
Y
G
G
P
Y
C
I
I
N
P
K
I
V
D
I
S
Q
-----
E
K
V
K
L
K
E
G
C
L
S
V
P
G
Y
F
D
Y
I
V
R
P
Q
R
I
A
V
Q
Y
L
D
Y
N
G
N
E
C
I
I
K
A
Q
G
W
L
A
R
C
L
Q
H
E
I
D
H
L
N
G
T
V
F
L
-
K
Y
L
S
K
F
K
--
R
D
F
A
I
E
K
V
K
K
K
E
R
T
D
L
I
-
23
PsiBlast_CBE
88.40
44%
-93
- C7 -
1N5N
2
DEF_PSEAE
B:
[14-177]
-
A
I
L
N
I
L
E
F
P
D
P
R
L
R
T
I
A
K
P
V
E
V
---
V
-----
D
D
A
V
R
Q
L
I
D
D
M
F
E
T
M
Y
E
A
P
-
G
I
G
L
A
A
T
Q
V
N
V
H
K
R
I
V
V
M
D
--------
L
S
E
D
K
S
E
-
P
R
V
F
---------
I
N
P
E
F
E
P
L
T
E
-----
E
M
D
Q
Y
Q
E
G
C
L
S
V
P
G
F
Y
E
N
V
D
R
P
Q
K
V
R
I
K
A
L
D
R
D
G
N
P
F
E
E
V
A
E
G
L
L
A
V
C
I
Q
H
E
C
D
H
L
N
G
K
L
F
V
-
D
Y
L
S
T
L
K
--
R
D
R
I
R
K
K
L
E
K
Q
H
R
-----
125
Fugue
87.95
43%
-94
- C7 -
1BS4
2
DEF_ECOLI
A:
[1-168]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
------
S
-----------
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
-
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
R
A
22
PsiBlast_CBE
87.31
44%
-93
- C7 -
1S17
2
DEF_PSEAE
B:
[14-177]
-
A
I
L
N
I
L
E
F
P
D
P
R
L
R
T
I
A
K
P
V
E
V
---
V
-----
D
D
A
V
R
Q
L
I
D
D
M
F
E
T
M
Y
E
A
P
-
G
I
G
L
A
A
T
Q
V
N
V
H
K
R
I
V
V
M
D
--------
L
S
E
D
K
S
E
-
P
R
V
F
---------
I
N
P
E
F
E
P
L
T
E
-----
E
M
D
Q
Y
Q
E
G
C
L
S
V
P
G
F
Y
E
N
V
D
R
P
Q
K
V
R
I
K
A
L
D
R
D
G
N
P
F
E
E
V
A
E
G
L
L
A
V
C
I
Q
H
E
C
D
H
L
N
G
K
L
F
V
-
D
Y
L
S
T
L
K
--
R
D
R
I
R
K
K
L
E
K
Q
H
R
-----
5
PsiBlast_PDB
86.96
44%
-92
- C7 -
1IX1
4
DEF_PSEAE
A:
[2-165]
-
A
I
L
N
I
L
E
F
P
D
P
R
L
R
T
I
A
K
P
V
E
V
---
V
-----
D
D
A
V
R
Q
L
I
D
D
M
F
E
T
M
Y
E
A
P
-
G
I
G
L
A
A
T
Q
V
N
V
H
K
R
I
V
V
M
D
--------
L
S
E
D
K
S
E
-
P
R
V
F
---------
I
N
P
E
F
E
P
L
T
E
-----
D
M
D
Q
Y
Q
E
G
C
L
S
V
P
G
F
Y
E
N
V
D
R
P
Q
K
V
R
I
K
A
L
D
R
D
G
N
P
F
E
E
V
A
E
G
L
L
A
V
C
I
Q
H
E
C
D
H
L
N
G
K
L
F
V
-
D
Y
L
S
T
L
K
--
R
D
R
I
R
K
K
L
E
K
Q
H
R
Q
Q
A
H
-
57
PsiBlast_CBE
86.70
42%
-102
- C7 -
1BS8
4
DEF_ECOLI
B:
[3-163]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
R
-
3
PsiBlast_PDB
86.68
44%
-92
- C7 -
1N5N
3
DEF_PSEAE
A:
[13-178]
M
A
I
L
N
I
L
E
F
P
D
P
R
L
R
T
I
A
K
P
V
E
V
---
V
-----
D
D
A
V
R
Q
L
I
D
D
M
F
E
T
M
Y
E
A
P
-
G
I
G
L
A
A
T
Q
V
N
V
H
K
R
I
V
V
M
D
--------
L
S
E
D
K
S
E
-
P
R
V
F
---------
I
N
P
E
F
E
P
L
T
E
-----
E
M
D
Q
Y
Q
E
G
C
L
S
V
P
G
F
Y
E
N
V
D
R
P
Q
K
V
R
I
K
A
L
D
R
D
G
N
P
F
E
E
V
A
E
G
L
L
A
V
C
I
Q
H
E
C
D
H
L
N
G
K
L
F
V
-
D
Y
L
S
T
L
K
--
R
D
R
I
R
K
K
L
E
K
Q
H
R
Q
Q
---
67
PsiBlast_CBE
86.65
35%
-98
- C7 -
3QU1
7
DEF2_VIBCH
A:
[4-171]
M
A
V
L
E
I
L
T
A
P
D
P
R
L
R
V
Q
S
K
Q
V
T
D
---
V
-----
A
-
S
V
Q
T
L
I
D
D
L
L
D
T
L
Y
A
T
D
N
G
I
G
L
A
A
P
Q
V
G
R
E
E
A
I
V
V
I
D
--------
L
S
D
N
R
D
Q
-
P
---------
L
V
L
I
N
P
K
V
V
S
G
S
N
-----
K
E
-
M
G
Q
E
G
C
L
S
V
P
D
Y
Y
A
D
V
E
R
Y
T
S
V
V
V
E
A
L
D
R
E
G
K
P
L
R
I
E
T
S
D
F
L
A
I
V
M
Q
H
E
I
D
H
L
S
G
N
L
F
I
-
D
Y
L
S
P
L
K
--
Q
Q
M
A
M
K
K
V
K
K
H
V
K
N
R
A
R
-
103
HHSearch
86.48
45%
-100
- C7 -
1N5N
3
DEF_PSEAE
A:
[13-177]
M
A
I
L
N
I
L
E
F
P
D
P
R
L
R
T
I
A
K
P
V
E
V
---
V
-----
D
D
A
V
R
Q
L
I
D
D
M
F
E
T
M
Y
E
A
P
-
G
I
G
L
A
A
T
Q
V
N
V
H
K
R
I
V
V
M
D
L
------
S
E
D
K
------------
S
E
P
R
V
F
I
N
P
E
F
E
P
L
T
E
-----
E
M
D
Q
Y
Q
E
G
C
L
S
V
P
G
F
Y
E
N
V
D
R
P
Q
K
V
R
I
K
A
L
D
R
D
G
N
P
F
E
E
V
A
E
G
L
L
A
V
C
I
Q
H
E
C
D
H
L
N
G
K
L
F
V
-
D
Y
L
S
T
L
K
--
R
D
R
I
R
K
K
L
E
K
Q
H
R
Q
Q
---
4
PsiBlast_PDB
86.48
44%
-90
- C7 -
1S17
3
DEF_PSEAE
A:
[14-178]
-
A
I
L
N
I
L
E
F
P
D
P
R
L
R
T
I
A
K
P
V
E
V
---
V
-----
D
D
A
V
R
Q
L
I
D
D
M
F
E
T
M
Y
E
A
P
-
G
I
G
L
A
A
T
Q
V
N
V
H
K
R
I
V
V
M
D
--------
L
S
E
D
K
S
E
-
P
R
V
F
---------
I
N
P
E
F
E
P
L
T
E
-----
E
M
D
Q
Y
Q
E
G
C
L
S
V
P
G
F
Y
E
N
V
D
R
P
Q
K
V
R
I
K
A
L
D
R
D
G
N
P
F
E
E
V
A
E
G
L
L
A
V
C
I
Q
H
E
C
D
H
L
N
G
K
L
F
V
-
D
Y
L
S
T
L
K
--
R
D
R
I
R
K
K
L
E
K
Q
H
R
Q
Q
---
66
PsiBlast_CBE
86.33
35%
-98
- C7 -
3QU1
9
DEF2_VIBCH
B:
[5-171]
-
A
V
L
E
I
L
T
A
P
D
P
R
L
R
V
Q
S
K
Q
V
T
D
---
V
-----
A
-
S
V
Q
T
L
I
D
D
L
L
D
T
L
Y
A
T
D
N
G
I
G
L
A
A
P
Q
V
G
R
E
E
A
I
V
V
I
D
--------
L
S
D
N
R
D
Q
-
P
---------
L
V
L
I
N
P
K
V
V
S
G
S
N
-----
K
E
-
M
G
Q
E
G
C
L
S
V
P
D
Y
Y
A
D
V
E
R
Y
T
S
V
V
V
E
A
L
D
R
E
G
K
P
L
R
I
E
T
S
D
F
L
A
I
V
M
Q
H
E
I
D
H
L
S
G
N
L
F
I
-
D
Y
L
S
P
L
K
--
Q
Q
M
A
M
K
K
V
K
K
H
V
K
N
R
A
R
-
45
PsiBlast_CBE
86.28
42%
-102
- C7 -
1ICJ
4
DEF_ECOLI
B:
[3-163]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
R
-
15
PsiBlast_PDB
86.10
42%
-104
- C7 -
1BS5
1
DEF_ECOLI
A:
[3-163]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
R
-
61
PsiBlast_CBE
86.06
42%
-102
- C7 -
1BS6
4
DEF_ECOLI
B:
[3-163]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
R
-
9
PsiBlast_PDB
86.06
42%
-101
- C7 -
3K6L
2
DEF_ECOLI
A:
[2-164]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
----
102
HHSearch
85.99
43%
-98
- C7 -
1XEO
2
DEF_ECOLI
A:
[1-165]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
------
S
E
N
R
------------
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
-
T
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
---
63
PsiBlast_CBE
85.96
42%
-104
- C7 -
1BS5
3
DEF_ECOLI
B:
[3-163]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
R
-
29
PsiBlast_CBE
85.96
39%
-111
- C7 -
4DR8
2
?
C:
[17-177]
-
P
P
L
D
L
H
Y
L
G
D
R
V
L
R
Q
P
A
K
R
V
S
R
---
I
-----
D
D
E
L
R
Q
T
I
R
Q
M
L
Q
T
M
Y
S
A
D
-
G
I
G
L
A
A
P
Q
V
G
I
N
K
Q
L
I
V
I
D
L
------
E
L
E
D
E
Q
A
P
-
P
---------
L
V
L
I
N
P
K
I
E
R
T
A
G
-----
D
L
E
Q
C
Q
E
G
C
L
S
I
P
G
V
Y
L
D
V
E
R
P
E
I
V
E
V
S
Y
K
D
E
N
G
R
P
Q
R
L
V
A
D
G
L
L
A
R
C
I
Q
H
E
M
D
H
L
N
G
V
L
F
V
D
R
V
E
N
R
L
E
--
L
N
E
A
L
D
K
K
G
F
A
V
Q
A
V
R
P
-
33
PsiBlast_CBE
85.84
42%
-113
- C7 -
4AL2
2
DEF_ECOLI
C:
[3-162]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
------
13
PsiBlast_PDB
85.80
42%
-100
- C7 -
1ICJ
2
DEF_ECOLI
A:
[3-163]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
R
-
54
PsiBlast_CBE
85.71
42%
-102
- C7 -
1BSZ
4
DEF_ECOLI
B:
[3-163]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
R
-
14
PsiBlast_PDB
85.63
42%
-99
- C7 -
1BS4
2
DEF_ECOLI
A:
[3-163]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
R
-
18
PsiBlast_PDB
85.59
42%
-105
- C7 -
1BS8
2
DEF_ECOLI
A:
[3-163]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
R
-
19
PsiBlast_PDB
85.58
42%
-100
- C7 -
1BSZ
2
DEF_ECOLI
A:
[3-163]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
R
-
44
PsiBlast_CBE
85.52
42%
-101
- C7 -
1ICJ
4
DEF_ECOLI
C:
[3-163]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
R
-
12
PsiBlast_PDB
85.50
42%
-102
- C7 -
2W3U
2
DEF_ECOLI
A:
[3-163]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
---
24
PsiBlast_CBE
85.45
44%
-94
- C7 -
1IX1
4
DEF_PSEAE
B:
[2-165]
-
A
I
L
N
I
L
E
F
P
D
P
R
L
R
T
I
A
K
P
V
E
V
---
V
-----
D
D
A
V
R
Q
L
I
D
D
M
F
E
T
M
Y
E
A
P
-
G
I
G
L
A
A
T
Q
V
N
V
H
K
R
I
V
V
M
D
--------
L
S
E
D
K
S
E
-
P
R
V
F
---------
I
N
P
E
F
E
P
L
T
E
-----
D
M
D
Q
Y
Q
E
G
C
L
S
V
P
G
F
Y
E
N
V
D
R
P
Q
K
V
R
I
K
A
L
D
R
D
G
N
P
F
E
E
V
A
E
G
L
L
A
V
C
I
Q
H
E
C
D
H
L
N
G
K
L
F
V
-
D
Y
L
S
T
L
K
--
R
D
R
I
R
K
K
L
E
K
Q
H
R
Q
Q
A
H
-
16
PsiBlast_PDB
85.45
42%
-107
- C7 -
1BS6
2
DEF_ECOLI
A:
[3-163]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
R
-
34
PsiBlast_CBE
85.39
42%
-109
- C7 -
4AL2
2
DEF_ECOLI
B:
[3-163]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
R
-
107
HHSearch
85.36
44%
-97
- C7 -
2W3T
3
DEF_ECOLI
A:
[1-163]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
------
S
E
N
R
------------
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
-
T
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
R
-
64
PsiBlast_CBE
85.35
42%
-102
- C7 -
1BS4
4
DEF_ECOLI
C:
[3-163]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
R
-
32
PsiBlast_CBE
85.33
42%
-99
- C7 -
3K6L
2
DEF_ECOLI
B:
[2-164]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
----
39
PsiBlast_CBE
85.25
42%
-101
- C7 -
1XEN
7
DEF_ECOLI
A:
[3-163]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
---
60
PsiBlast_CBE
85.20
42%
-103
- C7 -
1BS6
4
DEF_ECOLI
C:
[3-163]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
R
-
55
PsiBlast_CBE
85.12
42%
-104
- C7 -
1BSK
3
DEF_ECOLI
A:
[3-163]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
--
40
PsiBlast_CBE
85.08
42%
-101
- C7 -
1XEM
11
DEF_ECOLI
A:
[3-163]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
----
10
PsiBlast_PDB
85.02
42%
-106
- C7 -
4AL2
2
DEF_ECOLI
A:
[3-162]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
------
6
PsiBlast_PDB
85.02
43%
-96
- C7 -
1LRY
2
DEF_PSEAE
A:
[3-165]
---
L
N
I
L
E
F
P
D
P
R
L
R
T
I
A
K
P
V
E
V
---
V
-----
D
D
A
V
R
Q
L
I
D
D
M
F
E
T
M
Y
E
A
P
-
G
I
G
L
A
A
T
Q
V
N
V
H
K
R
I
V
V
M
D
--------
L
S
E
D
K
S
E
-
P
R
V
F
---------
I
N
P
E
F
E
P
L
T
E
-----
D
M
D
Q
Y
Q
E
G
C
L
S
V
P
G
F
Y
E
N
V
D
R
P
Q
K
V
R
I
K
A
L
D
R
D
G
N
P
F
E
E
V
A
E
G
L
L
A
V
C
I
Q
H
E
C
D
H
L
N
G
K
L
F
V
-
D
Y
L
S
T
L
K
--
R
D
R
I
R
K
K
L
E
K
Q
H
R
Q
----
126
Fugue
84.90
43%
-98
- C7 -
1G2A
2
DEF_ECOLI
A:
[1-164]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
------
S
-----------
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
-
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
----
37
PsiBlast_CBE
84.87
42%
-101
- C7 -
2AI8
2
DEF_ECOLI
A:
[3-163]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
--
28
PsiBlast_CBE
84.86
39%
-106
- C7 -
4DR8
2
?
D:
[17-177]
-
P
P
L
D
L
H
Y
L
G
D
R
V
L
R
Q
P
A
K
R
V
S
R
---
I
-----
D
D
E
L
R
Q
T
I
R
Q
M
L
Q
T
M
Y
S
A
D
-
G
I
G
L
A
A
P
Q
V
G
I
N
K
Q
L
I
V
I
D
L
------
E
L
E
D
E
Q
A
P
-
P
---------
L
V
L
I
N
P
K
I
E
R
T
A
G
-----
D
L
E
Q
C
Q
E
G
C
L
S
I
P
G
V
Y
L
D
V
E
R
P
E
I
V
E
V
S
Y
K
D
E
N
G
R
P
Q
R
L
V
A
D
G
L
L
A
R
C
I
Q
H
E
M
D
H
L
N
G
V
L
F
V
D
R
V
E
N
R
L
E
--
L
N
E
A
L
D
K
K
G
F
A
V
Q
A
V
R
P
-
51
PsiBlast_CBE
84.81
42%
-102
- C7 -
1G27
2
DEF_ECOLI
A:
[3-163]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
----
26
PsiBlast_CBE
84.66
39%
-113
- C7 -
4DR9
3
?
C:
[17-177]
-
P
P
L
D
L
H
Y
L
G
D
R
V
L
R
Q
P
A
K
R
V
S
R
---
I
-----
D
D
E
L
R
Q
T
I
R
Q
M
L
Q
T
M
Y
S
A
D
-
G
I
G
L
A
A
P
Q
V
G
I
N
K
Q
L
I
V
I
D
L
------
E
L
E
D
E
Q
A
P
-
P
---------
L
V
L
I
N
P
K
I
E
R
T
A
G
-----
D
L
E
Q
C
Q
E
G
C
L
S
I
P
G
V
Y
L
D
V
E
R
P
E
I
V
E
V
S
Y
K
D
E
N
G
R
P
Q
R
L
V
A
D
G
L
L
A
R
C
I
Q
H
E
M
D
H
L
N
G
V
L
F
V
D
R
V
E
N
R
L
E
--
L
N
E
A
L
D
K
K
G
F
A
V
Q
A
V
R
P
-
48
PsiBlast_CBE
84.62
42%
-103
- C7 -
1G2A
2
DEF_ECOLI
A:
[3-163]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
----
20
PsiBlast_PDB
84.59
42%
-103
- C7 -
1BSJ
3
DEF_ECOLI
A:
[3-163]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
--
35
PsiBlast_CBE
84.56
42%
-101
- C7 -
2AI8
2
DEF_ECOLI
C:
[3-163]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
--
65
PsiBlast_CBE
84.50
42%
-100
- C7 -
1BS4
4
DEF_ECOLI
B:
[3-163]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
R
-
8
PsiBlast_PDB
84.44
39%
-110
- C7 -
4DR8
3
?
A:
[17-177]
-
P
P
L
D
L
H
Y
L
G
D
R
V
L
R
Q
P
A
K
R
V
S
R
---
I
-----
D
D
E
L
R
Q
T
I
R
Q
M
L
Q
T
M
Y
S
A
D
-
G
I
G
L
A
A
P
Q
V
G
I
N
K
Q
L
I
V
I
D
L
------
E
L
E
D
E
Q
A
P
-
P
---------
L
V
L
I
N
P
K
I
E
R
T
A
G
-----
D
L
E
Q
C
Q
E
G
C
L
S
I
P
G
V
Y
L
D
V
E
R
P
E
I
V
E
V
S
Y
K
D
E
N
G
R
P
Q
R
L
V
A
D
G
L
L
A
R
C
I
Q
H
E
M
D
H
L
N
G
V
L
F
V
D
R
V
E
N
R
L
E
--
L
N
E
A
L
D
K
K
G
F
A
V
Q
A
V
R
P
-
47
PsiBlast_CBE
84.29
42%
-101
- C7 -
1G2A
2
DEF_ECOLI
B:
[3-163]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
----
38
PsiBlast_CBE
84.17
42%
-101
- C7 -
1XEO
2
DEF_ECOLI
A:
[3-163]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
---
42
PsiBlast_CBE
84.08
42%
-99
- C7 -
1LRU
4
DEF_ECOLI
B:
[3-163]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
----
53
PsiBlast_CBE
83.75
42%
-102
- C7 -
1BSZ
4
DEF_ECOLI
C:
[3-163]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
R
-
43
PsiBlast_CBE
83.65
42%
-103
- C7 -
1LRU
2
DEF_ECOLI
A:
[3-163]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
----
11
PsiBlast_PDB
83.64
42%
-101
- C7 -
2W3T
3
DEF_ECOLI
A:
[3-163]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
R
-
124
Fugue
83.63
42%
-104
* C7 *
1G2A
2
DEF_ECOLI
A:
[1-164]
-
S
V
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
V
------
S
-
E
N
R
D
---
E
--------
R
L
V
L
I
N
P
E
L
L
E
K
S
------
G
E
T
G
I
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
--
P
L
K
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
----
30
PsiBlast_CBE
83.58
39%
-111
- C7 -
4DR8
4
?
B:
[17-177]
-
P
P
L
D
L
H
Y
L
G
D
R
V
L
R
Q
P
A
K
R
V
S
R
---
I
-----
D
D
E
L
R
Q
T
I
R
Q
M
L
Q
T
M
Y
S
A
D
-
G
I
G
L
A
A
P
Q
V
G
I
N
K
Q
L
I
V
I
D
L
------
E
L
E
D
E
Q
A
P
-
P
---------
L
V
L
I
N
P
K
I
E
R
T
A
G
-----
D
L
E
Q
C
Q
E
G
C
L
S
I
P
G
V
Y
L
D
V
E
R
P
E
I
V
E
V
S
Y
K
D
E
N
G
R
P
Q
R
L
V
A
D
G
L
L
A
R
C
I
Q
H
E
M
D
H
L
N
G
V
L
F
V
D
R
V
E
N
R
L
E
--
L
N
E
A
L
D
K
K
G
F
A
V
Q
A
V
R
P
-
46
PsiBlast_CBE
83.57
42%
-102
- C7 -
1G2A
2
DEF_ECOLI
C:
[3-163]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
----
25
PsiBlast_CBE
83.50
39%
-109
- C7 -
4DR9
2
?
D:
[17-177]
-
P
P
L
D
L
H
Y
L
G
D
R
V
L
R
Q
P
A
K
R
V
S
R
---
I
-----
D
D
E
L
R
Q
T
I
R
Q
M
L
Q
T
M
Y
S
A
D
-
G
I
G
L
A
A
P
Q
V
G
I
N
K
Q
L
I
V
I
D
L
------
E
L
E
D
E
Q
A
P
-
P
---------
L
V
L
I
N
P
K
I
E
R
T
A
G
-----
D
L
E
Q
C
Q
E
G
C
L
S
I
P
G
V
Y
L
D
V
E
R
P
E
I
V
E
V
S
Y
K
D
E
N
G
R
P
Q
R
L
V
A
D
G
L
L
A
R
C
I
Q
H
E
M
D
H
L
N
G
V
L
F
V
D
R
V
E
N
R
L
E
--
L
N
E
A
L
D
K
K
G
F
A
V
Q
A
V
R
P
-
56
PsiBlast_CBE
83.42
42%
-104
- C7 -
1BS8
4
DEF_ECOLI
C:
[3-163]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
K
A
R
-
27
PsiBlast_CBE
83.37
39%
-111
- C7 -
4DR9
3
?
B:
[17-177]
-
P
P
L
D
L
H
Y
L
G
D
R
V
L
R
Q
P
A
K
R
V
S
R
---
I
-----
D
D
E
L
R
Q
T
I
R
Q
M
L
Q
T
M
Y
S
A
D
-
G
I
G
L
A
A
P
Q
V
G
I
N
K
Q
L
I
V
I
D
L
------
E
L
E
D
E
Q
A
P
-
P
---------
L
V
L
I
N
P
K
I
E
R
T
A
G
-----
D
L
E
Q
C
Q
E
G
C
L
S
I
P
G
V
Y
L
D
V
E
R
P
E
I
V
E
V
S
Y
K
D
E
N
G
R
P
Q
R
L
V
A
D
G
L
L
A
R
C
I
Q
H
E
M
D
H
L
N
G
V
L
F
V
D
R
V
E
N
R
L
E
--
L
N
E
A
L
D
K
K
G
F
A
V
Q
A
V
R
P
-
36
PsiBlast_CBE
83.34
42%
-104
- C7 -
2AI8
2
DEF_ECOLI
B:
[3-163]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
----
49
PsiBlast_CBE
83.31
42%
-101
- C7 -
1G27
2
DEF_ECOLI
C:
[3-163]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
----
68
PsiBlast_CBE
83.06
34%
-101
- C7 -
1RL4
3
?
B:
[10-176]
----
K
I
V
K
Y
P
D
P
I
L
R
R
R
S
E
E
V
T
N
---
F
-----
D
D
N
L
K
R
V
V
R
K
M
F
D
I
M
Y
E
S
K
-
G
I
G
L
S
A
P
Q
V
N
I
S
K
R
I
I
V
W
N
--------------------------
R
I
F
I
N
P
S
I
V
E
Q
S
L
-----
V
K
L
K
L
I
E
G
C
L
S
F
P
G
I
E
G
K
V
E
R
P
S
I
V
S
I
S
Y
Y
D
I
N
G
Y
K
H
L
K
I
L
K
G
I
H
S
R
I
F
Q
H
E
F
D
H
L
N
G
T
L
F
I
-
D
K
M
T
Q
V
D
--
K
K
K
V
R
P
K
L
N
E
L
I
R
D
Y
K
--
110
HHSearch
82.90
35%
-103
- C7 -
1RL4
3
?
A:
[10-174]
----
K
I
V
K
Y
P
D
P
I
L
R
R
R
S
E
E
V
T
N
---
F
-----
D
D
N
L
K
R
V
V
R
K
M
F
D
I
M
Y
E
S
K
-
G
I
G
L
S
A
P
Q
V
N
I
S
K
R
I
I
V
W
N
--------------------------
R
I
F
I
N
P
S
I
V
E
Q
S
L
-----
V
K
L
K
L
I
E
G
C
L
S
F
P
G
I
E
G
K
V
E
R
P
S
I
V
S
I
S
Y
Y
D
I
N
G
Y
K
H
L
K
I
L
K
G
I
H
S
R
I
F
Q
H
E
F
D
H
L
N
G
T
L
F
I
-
D
K
M
T
Q
V
D
--
K
K
K
V
R
P
K
L
N
E
L
I
R
D
----
50
PsiBlast_CBE
82.53
42%
-100
- C7 -
1G27
2
DEF_ECOLI
B:
[3-163]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
D
R
L
----
69
PsiBlast_CBE
82.50
34%
-103
- C7 -
1RL4
3
?
A:
[10-174]
----
K
I
V
K
Y
P
D
P
I
L
R
R
R
S
E
E
V
T
N
---
F
-----
D
D
N
L
K
R
V
V
R
K
M
F
D
I
M
Y
E
S
K
-
G
I
G
L
S
A
P
Q
V
N
I
S
K
R
I
I
V
W
N
--------------------------
R
I
F
I
N
P
S
I
V
E
Q
S
L
-----
V
K
L
K
L
I
E
G
C
L
S
F
P
G
I
E
G
K
V
E
R
P
S
I
V
S
I
S
Y
Y
D
I
N
G
Y
K
H
L
K
I
L
K
G
I
H
S
R
I
F
Q
H
E
F
D
H
L
N
G
T
L
F
I
-
D
K
M
T
Q
V
D
--
K
K
K
V
R
P
K
L
N
E
L
I
R
D
----
41
PsiBlast_CBE
81.73
42%
-104
- C7 -
1LRU
2
DEF_ECOLI
C:
[3-161]
---
L
Q
V
L
H
I
P
D
E
R
L
R
K
V
A
K
P
V
E
E
---
V
-----
N
A
E
I
Q
R
I
V
D
D
M
F
E
T
M
Y
A
E
E
-
G
I
G
L
A
A
T
Q
V
D
I
H
Q
R
I
I
V
I
D
-----------------
V
S
E
N
-
R
D
E
R
L
V
L
I
N
P
E
L
L
E
K
S
G
-----
E
T
G
I
-
E
E
G
C
L
S
I
P
E
Q
R
A
L
V
P
R
A
E
K
V
K
I
R
A
L
D
R
D
G
K
P
F
E
L
E
A
D
G
L
L
A
I
C
I
Q
H
E
M
D
H
L
V
G
K
L
F
M
-
D
Y
L
S
P
L
K
--
Q
Q
R
I
R
Q
K
V
E
K
L
-------
76
PsiBlast_CBE
80.04
39%
-99
- C7 -
1WS1
2
DEF1_BACCR
A:
[1-148]
M
A
V
L
E
I
I
K
H
P
N
E
V
L
E
T
P
C
E
R
V
I
N
---
F
-----
D
K
K
L
V
K
L
L
K
D
M
H
E
T
M
L
I
A
D
-
G
V
G
L
A
A
P
Q
V
G
V
S
L
Q
V
A
V
V
D
V
------
D
------------
D
-
D
T
G
K
I
E
L
I
N
P
S
I
L
E
K
R
G
-----
E
Q
V
-
G
P
E
G
C
L
S
F
P
G
L
Y
G
E
V
E
R
A
D
Y
I
K
V
R
A
Q
N
R
R
G
K
V
F
L
L
E
A
E
G
F
L
A
R
A
I
Q
H
E
I
D
H
L
H
G
V
L
F
T
-
S
K
V
T
R
Y
Y
--
E
-----------------
114
HHSearch
78.50
30%
-82
- C7 -
3E3U
4
DEF_MYCTU
A:
[2-179]
-
A
V
V
P
I
R
I
V
G
D
P
V
L
H
T
A
T
T
P
V
T
V
---
A
ADGSL
P
A
D
L
A
Q
L
I
A
T
M
Y
D
T
M
D
A
A
N
-
G
V
G
L
A
A
N
Q
I
G
C
S
L
R
L
F
V
Y
D
C
------
A
A
D
R
A
-------
M
T
-
A
R
R
R
G
V
V
I
N
P
V
L
E
T
S
E
I
PETMP
D
P
D
T
D
D
E
G
C
L
S
V
P
G
E
S
F
P
T
G
R
A
K
W
A
R
V
T
G
L
D
A
D
G
S
P
V
S
I
E
G
T
G
L
F
A
R
M
L
Q
H
E
T
G
H
L
D
G
F
L
Y
L
-
D
R
L
I
G
R
Y
--
A
R
N
A
K
R
A
V
K
S
H
G
W
G
V
P
G
-
109
HHSearch
75.98
38%
-101
- C7 -
3UWB
4
?
A:
[3-150]
---
L
K
I
K
T
I
G
D
R
C
L
R
Q
K
S
E
E
V
E
F
---
D
-----
K
K
E
M
S
E
L
Y
D
Q
M
C
E
A
M
W
A
S
D
-
G
I
G
L
A
A
P
Q
V
G
I
N
K
R
V
I
V
V
D
E
------
T
T
E
E
H
----------
G
K
Y
A
H
L
M
V
N
P
K
I
T
W
K
S
E
-----
E
K
V
L
F
D
E
G
C
L
S
V
P
D
Q
N
G
E
V
L
R
P
K
S
I
K
V
T
F
Q
N
K
D
G
K
Y
K
K
W
K
L
D
G
L
A
A
R
V
V
Q
H
E
I
D
H
L
E
G
I
L
F
V
-
D
Y
F
N
-----------------------
112
HHSearch
75.64
32%
-87
- C7 -
1Y6H
5
DEF_LEPIN
A:
[1-173]
-
S
V
R
K
I
L
R
M
G
D
P
I
L
R
K
I
S
E
P
V
T
E
DEI
Q
-----
T
K
E
F
K
K
L
I
R
D
M
F
D
T
M
R
H
A
E
-
G
V
G
L
A
A
P
Q
I
G
I
L
K
Q
I
V
V
V
G
S
------
E
D
N
E
R
Y
----
P
G
T
P
-
D
V
P
E
R
I
I
L
N
P
V
I
T
P
L
T
K
-----
D
T
S
G
F
W
E
G
C
L
S
V
P
G
M
R
G
Y
V
E
R
P
N
Q
I
R
M
Q
W
M
D
E
K
G
N
Q
F
D
E
T
I
D
G
Y
K
A
I
V
Y
Q
H
E
C
D
H
L
Q
G
I
L
Y
V
-
D
R
L
K
D
T
K
--
L
F
G
F
N
E
T
L
D
S
S
H
N
V
L
D
--
80
PsiBlast_CBE
69.87
38%
-104
- C7 -
1VEZ
8
DEF_LEPIN
B:
[29-161]
----------------------------------
E
F
K
K
L
I
R
D
M
F
D
T
M
R
H
A
E
-
G
V
G
L
A
A
P
Q
I
G
I
L
K
Q
I
V
V
--
V
------
G
S
E
D
N
E
R
Y
-
P
-
G
T
P
-
D
V
P
E
R
I
I
L
N
P
V
I
T
P
L
T
K
-----
D
T
S
G
F
W
E
G
C
L
S
V
P
G
M
R
G
Y
V
E
R
P
N
Q
I
R
M
Q
W
M
D
E
K
G
N
Q
F
D
E
T
I
D
G
Y
K
A
I
V
Y
Q
H
E
C
D
H
L
Q
G
I
L
Y
V
-
D
R
L
K
D
T
K
--
L
F
G
F
N
E
T
L
D
S
--------
84
PsiBlast_CBE
69.29
38%
-103
- C7 -
1VEV
3
DEF_LEPIN
B:
[29-161]
----------------------------------
E
F
K
K
L
I
R
D
M
F
D
T
M
R
H
A
E
-
G
V
G
L
A
A
P
Q
I
G
I
L
K
Q
I
V
V
--
V
------
G
S
E
D
N
E
R
Y
-
P
-
G
T
P
-
D
V
P
E
R
I
I
L
N
P
V
I
T
P
L
T
K
-----
D
T
S
G
F
W
E
G
C
L
S
V
P
G
M
R
G
Y
V
E
R
P
N
Q
I
R
M
Q
W
M
D
E
K
G
N
Q
F
D
E
T
I
D
G
Y
K
A
I
V
Y
Q
H
E
C
D
H
L
Q
G
I
L
Y
V
-
D
R
L
K
D
T
K
--
L
F
G
F
N
E
T
L
D
S
--------