@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0119: (2015-11-28 )
MTKRIINNVFAREILDSRGYPTVEVEIELCDGATGRASVPSGASTGKLEALELRDQDEKRYCGKGVLKAVKAVNGVIANAIIGMDAADQSTIDKALIELDGTRNKSKLGANATLGVSLASAKAAANSFKMPLYRYLGGEQANVMPFPLINIINGGVHADNKLDFQEFMILPIGAEAFSEAIRMSAEVFHNLRSILRKRGYSTNVGDEGGFAPNIESTEEALDLIVHAIESASYSTQNHFALGLDVASSTFYKNKIYKFANKELTSEELVEYYYNLVEKYPITSMEDAMSEDDYEGWKLLTAKLGSKVQLVGDDLFVTNCELIRKGIEEKMANAVLIKPNQIGTLTETFTAIGMTKSGGYKAVISHRSGETEDTTISHIAIASNCGQIKTGSLSRSDRLAKYNELIRIEGTLERNAKYYYGLAWTS
Atome Classification :
(58 SA)
.........10........20........30..----------......40........50........60........70........80.--.--......90........100.......110.......120.......130...---.----.---..-----140---.---.-----.......150.......160.......170.......180.......190--......-..--.--200........210.......220.......230.-......240.......250-.--..----..---------.--.-------.----------260----.---.------.--..-----....270.......280.......290.......300.......310.-......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420...----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
K
R
I
I
N
N
V
F
A
R
E
I
L
DSRGY
P
T
V
E
V
E
I
E
LCDGA----------TGRASVPSGASTG
K
L
E
A
L
ELRDQ
D
E
K
R
Y
C
G
K
G
V
L
K
A
V
K
A
V
N
G
V
I
A
N
A
I
I--G--MDAA
D
Q
S
T
I
D
K
A
L
I
ELDGTRNKSKLGAN
A
T
L
G
V
S
LA
S
A
K
AAANSFK
M
P
L
Y
R
Y---L----G---GE-----Q-----A---N-----VMP
F
P
L
I
N
IINGGVHADNKL
D
F
Q
E
F
M
I
L
PI
G
A
E
A
F
S
E
A
I
R
M
S
A
E
V
F
H
N
----
L
R
S
I
L
R
-KR--G--Y-STNVGDEGGFAPNI
E
S
T
E
E
A
L
D
L
I
V
H
A
I
E
SASY-STQN
H
F
A
L
G
L
DVASS
T
F
Y
--
K
--
N
K
----
I
Y
---------
K
--
F
-------A----------N------K---E------L--
T
S
-----
E
E
L
V
E
Y
Y
Y
N
L
V
E
KYPI
T
S
M
E
D
AMSEDDYE
G
W
K
L
L
T
A
KLG
S
K
V
Q
L
VGDD-
L
F
VT
N
C
E
L
I
R
K
G
I
E
E
KMA
N
A
V
L
IKPNQI
G
T
L
T
E
T
F
T
AIGMTKSG
G
Y
K
A
V
I
SHRSGETED
T
T
I
S
H
I
A
IASNCGQIKTGSLS
R
S
D
R
L
A
K
Y
N
E
L
I
R
I
E
G
T
LERN
A
K
Y
Y
Y
G
L
A
WTS----
33
PsiBlast_CBE
94.22
57%
-94
- C1 -
4YWS
1
ENO_CHLAA
B:
[4-418]
----
L
I
E
A
I
V
A
R
E
V
L
D
S
R
G
N
P
T
I
E
V
D
V
R
L
E
S
G
D
----------
V
G
R
A
I
V
P
S
G
----------
L
R
D
G
D
K
S
R
Y
N
G
K
G
V
L
K
A
V
Q
A
V
N
E
D
I
A
E
A
L
I
--
G
--
F
D
A
A
D
Q
I
A
L
D
Q
E
L
I
A
L
D
G
T
P
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
A
K
A
A
A
A
A
F
G
L
P
L
Y
R
Y
---
L
----
G
---
G
V
-----
Y
-----
A
---
H
-----
V
L
P
V
P
M
M
N
I
M
N
G
G
Q
H
A
T
---
D
F
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
G
L
R
W
G
A
E
I
Y
H
M
----
L
K
K
V
I
H
-
D
R
-------------
E
G
G
F
A
P
S
L
-
T
N
D
A
P
L
Q
L
I
M
E
A
I
E
K
A
G
Y
-
R
P
G
E
Q
I
V
I
A
L
D
P
A
T
T
E
I
F
------------
Y
HL-------
K
----------
E
----------
G
------
R
-------------
S
S
-----
A
E
M
V
D
Y
W
V
D
L
V
N
R
Y
P
I
I
S
L
E
D
G
L
A
E
D
D
W
E
G
W
A
L
L
-
A
K
L
G
D
R
V
Q
L
V
G
D
D
-
F
L
V
T
N
V
Q
R
L
Q
R
A
I
E
A
K
A
A
N
S
I
L
I
K
L
N
Q
I
G
S
L
T
E
T
L
S
A
I
Q
L
A
Q
R
S
G
W
T
A
V
V
S
H
R
S
G
-
S
E
D
V
T
I
A
D
L
V
V
A
T
N
A
G
Q
I
K
T
G
A
P
A
-
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
S
A
A
R
Y
A
G
R
S
A
F
K
V
----
5
PsiBlast_PDB
94.13
58%
-82
- C1 -
3ZLH
-
ENO_STRP6
A:
[23-444]
----
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
----
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
K
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
----
G
---
G
F
-----
N
-----
T
---
K
-----
V
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
M
P
V
G
A
P
T
F
K
E
G
L
R
W
G
A
E
V
F
H
A
----
L
K
K
I
L
K
-
E
R
--
G
--
L
-
V
T
A
V
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
G
V
E
T
I
L
K
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
DK
E
--
R
K
----
V
Y
---------
D
--
Y
-------
T
----------
K
------
F
---
E
GEG
A
A
V
R
--
T
S
-----
A
E
Q
V
D
Y
L
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
V
L
T
E
R
L
G
K
R
V
Q
L
V
G
D
D
-
F
F
V
T
N
T
E
Y
L
A
R
G
I
K
E
N
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
Q
Y
K
G
I
K
S
F
Y
N
----
115
HHSearch
93.93
58%
-76
- C1 -
1W6T
2
ENO_STRPN
A:
[11-440]
--
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
---
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
G
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
E
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
I
P
L
Y
S
Y
---
L
----
G
---
G
F
-----
N
-----
T
---
K
-----
V
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
L
P
V
G
A
P
T
F
K
E
A
L
R
Y
G
A
E
I
F
H
A
----
L
K
K
I
L
K
-
S
R
--
G
--
L
-
E
T
A
V
G
D
E
G
G
F
A
P
R
F
E
G
T
E
D
G
V
E
T
I
L
A
A
I
E
A
A
G
Y
-
V
P
G
K
D
V
F
L
G
F
D
C
A
S
S
E
F
Y
--
D
--
R
K
----
V
Y
---------
D
--
Y
-------
T
KFEGEG----
A
------
A
---
V
------
R
--
T
S
-----
A
E
Q
I
D
Y
L
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
A
L
T
E
R
L
G
K
K
V
Q
L
V
G
D
D
-
F
F
V
T
N
T
D
Y
L
A
R
G
I
Q
E
G
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
E
Y
R
G
L
K
S
F
Y
N
----
1
PsiBlast_PDB
93.84
61%
-81
- C1 -
1IYX
6
ENO_ENTHR
A:
[3-420]
----
I
I
T
D
V
Y
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
A
S
T
G
E
Y
E
A
V
E
L
R
D
G
D
K
A
R
Y
G
G
K
G
V
T
K
A
V
D
N
V
N
N
I
I
A
E
A
I
I
--
G
--
Y
D
V
R
D
Q
M
A
I
D
K
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
H
Y
---
L
----
G
---
G
F
-----
N
-----
T
---
K
-----
V
L
P
T
P
M
M
N
I
I
N
G
G
S
H
A
D
N
S
I
D
F
Q
E
F
M
I
M
P
V
G
A
P
T
F
K
E
A
L
R
M
G
A
E
V
F
H
A
----
L
A
A
I
L
K
-
S
R
--
G
--
L
-
A
T
S
V
G
D
E
G
G
F
A
P
N
L
G
S
N
E
E
G
F
E
V
I
I
E
A
I
E
K
A
G
Y
-
V
P
G
K
D
V
V
L
A
M
D
A
A
S
S
E
F
Y
--
D
--
K
E
KG--
V
Y
---------
V
--
L
-------
A
----------
D
------
S
GEG
E
------
K
--
T
T
-----
D
E
M
I
K
F
Y
E
E
L
V
S
K
Y
P
I
I
S
I
E
D
G
L
D
E
N
D
W
D
G
F
K
K
L
T
D
V
L
G
D
K
V
Q
L
V
G
D
D
-
L
F
V
T
N
T
Q
K
L
S
E
G
I
E
K
G
I
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
S
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
E
Y
K
G
L
K
S
F
Y
N
----
25
PsiBlast_CBE
93.80
58%
-77
- C1 -
3ZLF
2
ENO_STRP6
C:
[23-444]
----
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
A
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
K
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
----
G
---
G
F
-----
N
-----
T
---
K
-----
V
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
M
P
V
G
A
P
T
F
K
E
G
L
R
W
G
A
E
V
F
H
A
----
L
K
K
I
L
K
-
E
R
--
G
--
L
-
V
T
A
V
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
G
V
E
T
I
L
K
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
DK
E
--
R
K
----
V
Y
---------
D
--
Y
-------
T
----------
K
------
F
---
E
GEGAAV
R
--
T
S
-----
A
E
Q
V
D
Y
L
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
V
L
T
E
R
L
G
A
R
V
Q
L
V
G
D
D
-
F
F
V
T
N
T
E
Y
L
A
R
G
I
K
E
N
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
Q
Y
K
G
I
K
S
F
Y
N
----
3
PsiBlast_PDB
93.71
58%
-78
- C1 -
4A3R
-
ENO_BACSU
A:
[4-420]
-----
I
V
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
Y
T
E
T
G
A
----------
F
G
R
A
L
V
P
S
G
A
S
T
G
E
Y
E
A
V
E
L
R
D
G
D
K
D
R
Y
L
G
K
G
V
L
T
A
V
N
N
V
N
E
I
I
A
P
E
L
L
--
G
--
F
D
V
T
E
Q
N
A
I
D
Q
L
L
I
E
L
D
G
T
E
N
K
G
K
L
G
A
N
A
I
L
G
V
S
M
A
C
A
R
A
A
A
D
F
L
Q
I
P
L
Y
Q
Y
---
L
----
G
---
G
F
-----
N
-----
S
---
K
-----
T
L
P
V
P
M
M
N
I
V
N
G
G
E
H
A
D
N
N
V
D
I
Q
E
F
M
I
M
P
V
G
A
P
N
F
R
E
A
L
R
M
G
A
Q
I
F
H
S
----
L
K
S
V
L
S
-
A
K
--
G
--
L
-
N
T
A
V
G
D
E
G
G
F
A
P
N
L
G
S
N
E
E
A
L
Q
T
I
V
E
A
I
E
K
A
G
F
-
K
P
G
E
E
V
K
L
A
M
D
A
A
S
S
E
F
Y
NK
E
--
D
G
----
K
Y
---------
H
--
L
-------
S
----------
G
------
E
---
G
------
V
V
K
T
S
-----
A
E
M
V
D
W
Y
E
E
L
V
S
K
Y
P
I
I
S
I
E
D
G
L
D
E
N
D
W
E
G
H
K
L
L
T
E
R
L
G
K
K
V
Q
L
V
G
D
D
-
L
F
V
T
N
T
K
K
L
S
E
G
I
K
N
G
V
G
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
D
A
I
E
M
A
K
R
A
G
Y
T
A
V
I
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
A
P
S
R
T
D
R
V
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
A
E
T
A
Q
Y
H
G
I
N
S
F
Y
N
----
2
PsiBlast_PDB
93.65
59%
-79
- C1 -
4ROP
6
ENO_SYNP6
A:
[9-419]
-----
I
A
E
I
T
A
R
E
I
L
D
S
R
G
R
P
T
V
E
A
E
V
H
L
E
D
G
S
----------
V
G
L
A
Q
V
P
S
G
A
S
T
G
T
F
E
A
H
E
L
R
D
D
D
P
S
R
Y
G
G
K
G
V
Q
K
A
V
E
N
V
S
-
A
I
E
D
A
L
I
--
G
--
L
S
A
L
D
Q
E
G
L
D
K
A
M
I
A
L
D
G
T
P
N
K
K
N
L
G
A
N
A
I
L
A
V
S
L
A
T
A
H
A
A
A
T
S
L
N
L
P
L
Y
R
Y
---
L
----
G
---
G
P
-----
L
-----
A
---
N
-----
V
L
P
V
P
M
M
N
V
I
N
G
G
A
H
A
D
N
N
V
D
F
Q
E
F
M
I
M
P
V
G
A
P
S
F
K
E
A
L
R
W
G
A
E
V
F
H
A
----
L
A
K
V
L
K
-
D
K
--
G
--
L
-
A
T
G
V
G
D
E
G
G
F
A
P
N
L
G
S
N
K
E
A
L
E
L
L
L
T
A
I
E
A
A
G
Y
-
K
P
G
E
Q
V
A
L
A
M
D
V
A
S
S
E
F
Y
--
K
--
N
G
----
L
Y
---------
T
--
C
-------
D
----------
G
------
V
---
S
------
H
--
E
P
-----
A
G
M
I
G
I
L
A
D
L
V
S
Q
Y
P
I
V
S
I
E
D
G
L
Q
E
D
D
W
S
N
W
K
T
L
T
Q
Q
L
G
S
T
V
Q
L
V
G
D
D
-
L
F
V
T
N
P
D
R
L
Q
S
G
I
E
Q
G
V
G
N
A
V
L
I
K
L
N
Q
I
G
T
L
T
E
T
L
R
T
I
D
L
A
T
R
S
G
Y
R
S
V
I
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
T
R
A
G
Q
I
K
T
G
S
L
S
R
S
E
R
I
A
K
Y
N
R
L
L
R
I
E
A
A
L
G
E
N
A
L
Y
A
G
A
I
G
L
G
P
----
29
PsiBlast_CBE
93.62
58%
-76
- C1 -
3ZLG
2
ENO_STRP6
C:
[23-444]
----
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
A
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
K
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
----
G
---
G
F
-----
N
-----
T
---
K
-----
V
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
M
P
V
G
A
P
T
F
K
E
G
L
R
W
G
A
E
V
F
H
A
----
L
K
K
I
L
K
-
E
R
--
G
--
L
-
V
T
A
V
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
G
V
E
T
I
L
K
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
DK
E
--
R
K
----
V
Y
---------
D
--
Y
-------
T
----------
K
------
F
---
E
GEGAAV
R
--
T
S
-----
A
E
Q
V
D
Y
L
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
V
L
T
E
R
L
G
K
R
V
Q
L
V
G
D
D
-
F
F
V
T
N
T
E
Y
L
A
R
G
I
K
E
N
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
A
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
Q
Y
K
G
I
K
S
F
Y
N
----
118
HHSearch
93.50
55%
-80
- C1 -
3UJ2
5
?
A:
[24-448]
-
N
Y
L
E
I
E
K
V
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
Y
L
A
G
G
V
----------
T
G
R
G
T
A
P
S
G
---
G
E
F
E
A
L
E
L
R
D
G
D
K
G
R
F
G
G
K
G
V
T
K
A
V
Q
N
I
N
T
E
I
S
E
I
L
S
--
G
--
M
D
A
S
D
I
Y
A
V
D
R
A
M
I
D
A
D
G
T
K
D
K
S
K
F
G
A
N
A
V
L
A
V
S
I
A
C
A
K
A
A
A
A
A
L
G
V
P
L
Y
R
F
---
L
----
G
---
G
L
-----
N
-----
A
---
N
-----
R
L
P
V
P
M
M
N
I
L
N
G
G
A
H
A
A
N
T
V
D
V
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
A
L
R
Q
C
T
E
V
F
H
A
----
L
A
G
L
L
K
-
S
K
--
G
--
L
-
A
T
S
V
G
D
E
G
G
F
A
P
D
L
A
S
D
E
E
A
I
E
Y
I
L
E
A
V
K
L
A
G
Y
-
E
P
G
R
D
F
V
L
A
M
D
A
A
S
S
E
W
K
GE
K
--
K
G
----
E
Y
---------
I
--
L
-------
P
----------
K
CK----
R
---
K
------
F
--
A
S
-----
E
E
L
V
A
H
W
K
S
L
C
E
R
Y
P
I
V
S
I
E
D
G
L
D
E
E
D
W
E
G
W
Q
Y
M
T
R
E
L
G
D
K
I
Q
L
V
G
D
D
-
L
F
V
T
N
T
E
R
L
N
K
G
I
K
E
R
C
G
N
S
I
L
I
K
L
N
Q
I
G
T
V
S
E
T
L
E
A
I
K
M
A
H
K
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
L
N
T
G
Q
I
K
T
G
A
P
S
R
S
E
R
V
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
D
S
A
V
Y
P
G
F
T
T
F
------
7
PsiBlast_PDB
93.43
58%
-80
- C1 -
4EWJ
-
?
A:
[3-424]
----
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
---
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
V
I
A
D
A
I
I
--
G
--
F
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
----
G
---
G
F
-----
N
-----
T
---
K
-----
V
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
L
P
V
G
A
P
S
F
K
E
G
L
R
W
G
A
E
V
F
H
A
----
L
K
K
I
L
K
-
A
R
--
G
--
L
-
V
T
A
V
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
G
V
E
T
I
I
E
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
D----
R
K
----
V
Y
---------
D
--
Y
-------
T
----------
K
------
F
---
E
GEG
A
A
V
R
--
T
S
-----
A
E
Q
I
D
Y
L
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
A
L
T
E
R
L
G
K
R
V
Q
L
V
G
D
D
-
F
F
V
T
N
T
D
Y
L
A
R
G
I
K
E
G
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
V
Y
K
G
L
N
S
F
Y
N
----
28
PsiBlast_CBE
93.33
58%
-76
- C1 -
3ZLG
2
ENO_STRP6
D:
[23-444]
----
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
A
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
K
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
----
G
---
G
F
-----
N
-----
T
---
K
-----
V
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
M
P
V
G
A
P
T
F
K
E
G
L
R
W
G
A
E
V
F
H
A
----
L
K
K
I
L
K
-
E
R
--
G
--
L
-
V
T
A
V
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
G
V
E
T
I
L
K
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
DK
E
--
R
K
----
V
Y
---------
D
--
Y
-------
T
----------
K
------
F
---
E
GEGAAV
R
--
T
S
-----
A
E
Q
V
D
Y
L
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
V
L
T
E
R
L
G
K
R
V
Q
L
V
G
D
D
-
F
F
V
T
N
T
E
Y
L
A
R
G
I
K
E
N
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
A
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
Q
Y
K
G
I
K
S
F
Y
N
----
10
PsiBlast_PDB
93.30
55%
-81
- C1 -
3UJ2
5
?
A:
[28-443]
-----
I
E
K
V
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
Y
L
A
G
G
V
----------
T
G
R
G
T
A
P
S
G
---
G
E
F
E
A
L
E
L
R
D
G
D
K
G
R
F
G
G
K
G
V
T
K
A
V
Q
N
I
N
T
E
I
S
E
I
L
S
--
G
--
M
D
A
S
D
I
Y
A
V
D
R
A
M
I
D
A
D
G
T
K
D
K
S
K
F
G
A
N
A
V
L
A
V
S
I
A
C
A
K
A
A
A
A
A
L
G
V
P
L
Y
R
F
---
L
----
G
---
G
L
-----
N
-----
A
---
N
-----
R
L
P
V
P
M
M
N
I
L
N
G
G
A
H
A
A
N
T
V
D
V
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
A
L
R
Q
C
T
E
V
F
H
A
----
L
A
G
L
L
K
-
S
K
--
G
--
L
-
A
T
S
V
G
D
E
G
G
F
A
P
D
L
A
S
D
E
E
A
I
E
Y
I
L
E
A
V
K
L
A
G
Y
-
E
P
G
R
D
F
V
L
A
M
D
A
A
S
S
E
W
K
--
G
--
E
K
KG
E
Y
I
L
---------
P
--
K
-------
C
----------
K
------
R
---
K
------
F
--
A
S
-----
E
E
L
V
A
H
W
K
S
L
C
E
R
Y
P
I
V
S
I
E
D
G
L
D
E
E
D
W
E
G
W
Q
Y
M
T
R
E
L
G
D
K
I
Q
L
V
G
D
D
-
L
F
V
T
N
T
E
R
L
N
K
G
I
K
E
R
C
G
N
S
I
L
I
K
L
N
Q
I
G
T
V
S
E
T
L
E
A
I
K
M
A
H
K
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
L
N
T
G
Q
I
K
T
G
A
P
S
R
S
E
R
V
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
D
S
A
V
Y
P
G
F
T
T
F
------
30
PsiBlast_CBE
93.19
58%
-76
- C1 -
3ZLG
2
ENO_STRP6
B:
[23-444]
----
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
A
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
K
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
----
G
---
G
F
-----
N
-----
T
---
K
-----
V
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
M
P
V
G
A
P
T
F
K
E
G
L
R
W
G
A
E
V
F
H
A
----
L
K
K
I
L
K
-
E
R
--
G
--
L
-
V
T
A
V
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
G
V
E
T
I
L
K
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
DK
E
--
R
K
----
V
Y
---------
D
--
Y
-------
T
----------
K
------
F
---
E
GEGAAV
R
--
T
S
-----
A
E
Q
V
D
Y
L
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
V
L
T
E
R
L
G
K
R
V
Q
L
V
G
D
D
-
F
F
V
T
N
T
E
Y
L
A
R
G
I
K
E
N
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
A
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
Q
Y
K
G
I
K
S
F
Y
N
----
22
PsiBlast_CBE
93.06
58%
-79
- C1 -
4A3R
3
ENO_BACSU
D:
[4-420]
-----
I
V
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
Y
T
E
T
G
A
----------
F
G
R
A
L
V
P
S
G
A
S
T
G
E
Y
E
A
V
E
L
R
D
G
D
K
D
R
Y
L
G
K
G
V
L
T
A
V
N
N
V
N
E
I
I
A
P
E
L
L
--
G
--
F
D
V
T
E
Q
N
A
I
D
Q
L
L
I
E
L
D
G
T
E
N
K
G
K
L
G
A
N
A
I
L
G
V
S
M
A
C
A
R
A
A
A
D
F
L
Q
I
P
L
Y
Q
Y
---
L
----
G
---
G
F
-----
N
-----
S
---
K
-----
T
L
P
V
P
M
M
N
I
V
N
G
G
E
H
A
D
N
N
V
D
I
Q
E
F
M
I
M
P
V
G
A
P
N
F
R
E
A
L
R
M
G
A
Q
I
F
H
S
----
L
K
S
V
L
S
-
A
K
--
G
--
L
-
N
T
A
V
G
D
E
G
G
F
A
P
N
L
G
S
N
E
E
A
L
Q
T
I
V
E
A
I
E
K
A
G
F
-
K
P
G
E
E
V
K
L
A
M
D
A
A
S
S
E
F
Y
NK
E
--
D
G
----
K
Y
---------
H
--
L
-------
S
----------
G
------
E
---
G
------
V
VK
T
S
-----
A
E
M
V
D
W
Y
E
E
L
V
S
K
Y
P
I
I
S
I
E
D
G
L
D
E
N
D
W
E
G
H
K
L
L
T
E
R
L
G
K
K
V
Q
L
V
G
D
D
-
L
F
V
T
N
T
K
K
L
S
E
G
I
K
N
G
V
G
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
D
A
I
E
M
A
K
R
A
G
Y
T
A
V
I
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
A
P
S
R
T
D
R
V
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
A
E
T
A
Q
Y
H
G
I
N
S
F
Y
N
----
43
PsiBlast_CBE
92.98
56%
-78
- C1 -
2FYM
2
ENO_ECOLI
F:
[3-421]
-----
I
V
K
I
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
H
L
E
G
G
F
----------
V
G
M
A
A
A
P
S
G
A
S
T
G
S
R
E
A
L
E
L
R
D
G
D
K
S
R
F
L
G
K
G
V
T
K
A
V
A
A
V
N
G
P
I
A
Q
A
L
I
--
G
--
K
D
A
K
D
Q
A
G
I
D
K
I
M
I
D
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
A
V
S
L
A
N
A
K
A
A
A
A
A
K
G
M
P
L
Y
E
H
---
I
AELN
G
---
T
P
-----
G
-----
K
---
Y
-----
S
M
P
V
P
M
M
N
I
I
N
G
G
E
H
A
D
N
N
V
D
I
Q
E
F
M
I
Q
P
V
G
A
K
T
V
K
E
A
I
R
M
G
S
E
V
F
H
H
----
L
A
K
V
L
K
-
A
K
--
G
--
M
-
N
T
A
V
G
D
E
G
G
Y
A
P
N
L
G
S
N
A
E
A
L
A
V
I
A
E
A
V
K
A
A
G
Y
-
E
L
G
K
D
I
T
L
A
M
D
C
A
A
S
E
F
Y
--
K
--
D
G
----
K
Y
---------
V
--
L
-------
A
GEG-------
N
------
K
---
A
------
F
--
T
S
-----
E
E
F
T
H
F
L
E
E
L
T
K
Q
Y
P
I
V
S
I
E
D
G
L
D
E
S
D
W
D
G
F
A
Y
Q
T
K
V
L
G
D
K
I
Q
L
V
G
D
D
-
L
F
V
T
N
T
K
I
L
K
E
G
I
E
K
G
I
A
N
S
I
L
I
K
F
N
Q
I
G
S
L
T
E
T
L
A
A
I
K
M
A
K
D
A
G
Y
T
A
V
I
S
H
R
S
G
E
T
E
D
A
T
I
A
D
L
A
V
G
T
A
A
G
Q
I
K
T
G
S
M
S
R
S
D
R
V
A
K
Y
N
Q
L
I
R
I
E
E
A
L
G
E
K
A
P
Y
N
G
R
K
E
I
K
G
----
21
PsiBlast_CBE
92.72
61%
-77
- C1 -
1IYX
5
ENO_ENTHR
B:
[3-420]
----
I
I
T
D
V
Y
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
A
S
T
G
E
Y
E
A
V
E
L
R
D
G
D
K
A
R
Y
G
G
K
G
V
T
K
A
V
D
N
V
N
N
I
I
A
E
A
I
I
--
G
--
Y
D
V
R
D
Q
M
A
I
D
K
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
H
Y
---
L
----
G
---
G
F
-----
N
-----
T
---
K
-----
V
L
P
T
P
M
M
N
I
I
N
G
G
S
H
A
D
N
S
I
D
F
Q
E
F
M
I
M
P
V
G
A
P
T
F
K
E
A
L
R
M
G
A
E
V
F
H
A
----
L
A
A
I
L
K
-
S
R
--
G
--
L
-
A
T
S
V
G
D
E
G
G
F
A
P
N
L
G
S
N
E
E
G
F
E
V
I
I
E
A
I
E
K
A
G
Y
-
V
P
G
K
D
V
V
L
A
M
D
A
A
S
S
E
F
Y
--
D
--
K
E
KG--
V
Y
---------
V
--
L
-------
A
----------
D
------
S
GEG
E
------
K
--
T
T
-----
D
E
M
I
K
F
Y
E
E
L
V
S
K
Y
P
I
I
S
I
E
D
G
L
D
E
N
D
W
D
G
F
K
K
L
T
D
V
L
G
D
K
V
Q
L
V
G
D
D
-
L
F
V
T
N
T
Q
K
L
S
E
G
I
E
K
G
I
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
S
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
E
Y
K
G
L
K
S
F
Y
N
----
41
PsiBlast_CBE
92.70
56%
-78
- C1 -
3H8A
1
ENO_ECOLI
D:
[4-422]
-----
I
V
K
I
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
H
L
E
G
G
F
----------
V
G
M
A
A
A
P
S
G
A
S
T
G
S
R
E
A
L
E
L
R
D
G
D
K
S
R
F
L
G
K
G
V
T
K
A
V
A
A
V
N
G
P
I
A
Q
A
L
I
--
G
--
K
D
A
K
D
Q
A
G
I
D
K
I
M
I
D
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
A
V
S
L
A
N
A
K
A
A
A
A
A
K
G
M
P
L
Y
E
H
---
I
AELN
G
---
T
P
-----
G
-----
K
---
Y
-----
S
M
P
V
P
M
M
N
I
I
N
G
G
E
H
A
D
N
N
V
D
I
Q
E
F
M
I
Q
P
V
G
A
K
T
V
K
E
A
I
R
M
G
S
E
V
F
H
H
----
L
A
K
V
L
K
-
A
K
--
G
--
M
-
N
T
A
V
G
D
E
G
G
Y
A
P
N
L
G
S
N
A
E
A
L
A
V
I
A
E
A
V
K
A
A
G
Y
-
E
L
G
K
D
I
T
L
A
M
D
C
A
A
S
E
F
Y
--
K
--
D
G
----
K
Y
---------
V
--
L
-------
A
GEG-------
N
------
K
---
A
------
F
--
T
S
-----
E
E
F
T
H
F
L
E
E
L
T
K
Q
Y
P
I
V
S
I
E
D
G
L
D
E
S
D
W
D
G
F
A
Y
Q
T
K
V
L
G
D
K
I
Q
L
V
G
D
D
-
L
F
V
T
N
T
K
I
L
K
E
G
I
E
K
G
I
A
N
S
I
L
I
K
F
N
Q
I
G
S
L
T
E
T
L
A
A
I
K
M
A
K
D
A
G
Y
T
A
V
I
S
H
R
S
G
E
T
E
D
A
T
I
A
D
L
A
V
G
T
A
A
G
Q
I
K
T
G
S
M
S
R
S
D
R
V
A
K
Y
N
Q
L
I
R
I
E
E
A
L
G
E
K
A
P
Y
N
G
R
K
E
I
K
G
----
27
PsiBlast_CBE
92.69
58%
-76
- C1 -
1W6T
2
ENO_STRPN
B:
[13-433]
----
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
---
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
G
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
E
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
I
P
L
Y
S
Y
---
L
----
G
---
G
F
-----
N
-----
T
---
K
-----
V
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
L
P
V
G
A
P
T
F
K
E
A
L
R
Y
G
A
E
I
F
H
A
----
L
K
K
I
L
K
-
S
R
--
G
--
L
-
E
T
A
V
G
D
E
G
G
F
A
P
R
F
E
G
T
E
D
G
V
E
T
I
L
A
A
I
E
A
A
G
Y
-
V
P
G
K
D
V
F
L
G
F
D
C
A
S
S
E
F
Y
DK
E
--
R
K
----
V
Y
---------
D
--
Y
-------
T
----------
K
------
F
---
E
GEG
A
A
V
R
--
T
S
-----
A
E
Q
I
D
Y
L
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
A
L
T
E
R
L
G
K
K
V
Q
L
V
G
D
D
-
F
F
V
T
N
T
D
Y
L
A
R
G
I
Q
E
G
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
E
Y
R
G
L
K
S
F
Y
N
----
24
PsiBlast_CBE
92.59
58%
-74
- C1 -
3ZLF
2
ENO_STRP6
D:
[23-444]
----
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
A
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
K
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
----
G
---
G
F
-----
N
-----
T
---
K
-----
V
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
M
P
V
G
A
P
T
F
K
E
G
L
R
W
G
A
E
V
F
H
A
----
L
K
K
I
L
K
-
E
R
--
G
--
L
-
V
T
A
V
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
G
V
E
T
I
L
K
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
DK
E
--
R
K
----
V
Y
---------
D
--
Y
-------
T
----------
K
------
F
---
E
GEGAAV
R
--
T
S
-----
A
E
Q
V
D
Y
L
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
V
L
T
E
R
L
G
A
R
V
Q
L
V
G
D
D
-
F
F
V
T
N
T
E
Y
L
A
R
G
I
K
E
N
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
Q
Y
K
G
I
K
S
F
Y
N
----
38
PsiBlast_CBE
92.53
55%
-79
- C1 -
3UJ2
4
?
D:
[28-443]
-----
I
E
K
V
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
Y
L
A
G
G
V
----------
T
G
R
G
T
A
P
S
G
---
G
E
F
E
A
L
E
L
R
D
G
D
K
G
R
F
G
G
K
G
V
T
K
A
V
Q
N
I
N
T
E
I
S
E
I
L
S
--
G
--
M
D
A
S
D
I
Y
A
V
D
R
A
M
I
D
A
D
G
T
K
D
K
S
K
F
G
A
N
A
V
L
A
V
S
I
A
C
A
K
A
A
A
A
A
L
G
V
P
L
Y
R
F
---
L
----
G
---
G
L
-----
N
-----
A
---
N
-----
R
L
P
V
P
M
M
N
I
L
N
G
G
A
H
A
A
N
T
V
D
V
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
A
L
R
Q
C
T
E
V
F
H
A
----
L
A
G
L
L
K
-
S
K
--
G
--
L
-
A
T
S
V
G
D
E
G
G
F
A
P
D
L
A
S
D
E
E
A
I
E
Y
I
L
E
A
V
K
L
A
G
Y
-
E
P
G
R
D
F
V
L
A
M
D
A
A
S
S
E
W
K
--
G
--
E
K
KGEY
I
L
---------
P
--
K
-------
C
----------
K
------
R
---
K
------
F
--
A
S
-----
E
E
L
V
A
H
W
K
S
L
C
E
R
Y
P
I
V
S
I
E
D
G
L
D
E
E
D
W
E
G
W
Q
Y
M
T
R
E
L
G
D
K
I
Q
L
V
G
D
D
-
L
F
V
T
N
T
E
R
L
N
K
G
I
K
E
R
C
G
N
S
I
L
I
K
L
N
Q
I
G
T
V
S
E
T
L
E
A
I
K
M
A
H
K
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
L
N
T
G
Q
I
K
T
G
A
P
S
R
S
E
R
V
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
D
S
A
V
Y
P
G
F
T
T
F
------
8
PsiBlast_PDB
91.71
57%
-79
- C1 -
4Z17
3
ENO_CHLAA
A:
[4-418]
----
L
I
E
A
I
V
A
R
E
V
L
D
S
R
G
N
P
T
I
E
V
D
V
R
L
E
S
G
D
----------
V
G
R
A
I
V
P
S
G
A
S
T
G
A
H
E
A
L
E
L
R
D
G
D
K
S
R
Y
N
G
K
G
V
L
K
A
V
Q
A
V
N
E
D
I
A
E
A
L
I
--
G
--
F
D
A
A
D
Q
I
A
L
D
Q
E
L
I
A
L
D
G
T
P
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
A
K
A
A
A
A
A
F
G
L
P
L
Y
R
Y
---
L
----
G
---
G
V
-----
Y
-----
A
---
H
-----
V
L
P
V
P
M
M
N
I
M
N
G
G
Q
H
--
N
S
T
D
F
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
G
L
R
W
G
A
E
I
Y
H
M
----
L
K
K
V
I
H
-
D
R
--
G
--
F
-
S
T
T
V
G
D
E
G
G
F
A
P
S
L
P
T
N
D
A
P
L
Q
L
I
M
E
A
I
E
K
A
G
Y
-
R
P
G
E
Q
I
V
I
A
L
D
P
A
T
T
E
I
F
--
E
--
D
G
----
K
Y
HL-------
K
--
R
-------
E
----------
G
------
R
---
S
------
L
--
S
S
-----
A
E
M
V
D
Y
W
V
D
L
V
N
R
Y
P
I
I
S
L
E
D
G
L
A
E
D
D
W
E
G
W
A
L
L
R
A
K
L
G
D
R
V
Q
L
V
G
D
D
-
F
L
V
T
N
V
Q
R
L
Q
R
A
I
E
A
K
A
A
N
S
I
L
I
K
L
N
Q
I
G
S
L
T
E
T
L
S
A
I
Q
L
A
Q
R
S
G
W
T
A
V
V
S
H
R
S
G
E
S
E
D
V
T
I
A
D
L
V
V
A
T
N
A
G
Q
I
K
T
G
A
P
A
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
S
A
A
R
Y
A
G
R
S
A
F
K
V
----
32
PsiBlast_CBE
89.83
57%
-80
- C1 -
4Z17
3
ENO_CHLAA
B:
[4-418]
----
L
I
E
A
I
V
A
R
E
V
L
D
S
R
G
N
P
T
I
E
V
D
V
R
L
E
S
G
D
----------
V
G
R
A
I
V
P
S
G
A
S
T
G
A
H
E
A
L
E
L
R
D
G
D
K
S
R
Y
N
G
K
G
V
L
K
A
V
Q
A
V
N
E
D
I
A
E
A
L
I
--
G
--
F
D
A
A
D
Q
I
A
L
D
Q
E
L
I
A
L
D
G
T
P
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
A
K
A
A
A
A
A
F
G
L
P
L
Y
R
Y
---
L
----
G
---
G
V
-----
Y
-----
A
---
H
-----
V
L
P
V
P
M
M
N
I
M
N
G
G
Q
H
A
-----
F
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
G
L
R
W
G
A
E
I
Y
H
M
----
L
K
K
V
I
H
-
D
R
--
G
--
F
-
S
T
T
V
G
D
E
G
G
F
A
P
S
L
P
T
N
D
A
P
L
Q
L
I
M
E
A
I
E
K
A
G
Y
-
R
P
G
E
Q
I
V
I
A
L
D
P
A
T
T
E
I
F
--
E
--
D
G
----
K
Y
HL-------
K
--
R
-------
E
----------
G
------
R
---
S
------
L
--
S
S
-----
A
E
M
V
D
Y
W
V
D
L
V
N
R
Y
P
I
I
S
L
E
D
G
L
A
E
D
D
W
E
G
W
A
L
L
R
A
K
L
G
D
R
V
Q
L
V
G
D
D
-
F
L
V
T
N
V
Q
R
L
Q
R
A
I
E
A
K
A
A
N
S
I
L
I
K
L
N
Q
I
G
S
L
T
E
T
L
S
A
I
Q
L
A
Q
R
S
G
W
T
A
V
V
S
H
R
S
G
E
S
E
D
V
T
I
A
D
L
V
V
A
T
N
A
G
Q
I
K
T
G
A
P
A
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
S
A
A
R
Y
A
G
R
S
A
F
K
V
----
54
PsiBlast_CBE
89.61
49%
-75
- C1 -
3UJS
4
ENOG_HUMAN
A:
[2-422]
-----
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
----
A
---
G
N
-----
S
-----
D
---
L
-----
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
-
D
K
YG
K
--
D
-
A
T
N
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
-
T
E
K
--
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
G
----
K
Y
---------
D
--
L
DFKSPTD
P
----------
S
------
R
---
Y
------
I
--
T
G
-----
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
F
R
N
P
----
17
PsiBlast_PDB
89.26
49%
-75
- C1 -
3UCC
4
ENOG_HUMAN
A:
[2-422]
-----
I
Q
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
----
A
---
G
N
-----
S
-----
D
---
L
-----
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
-
D
K
YG
K
--
D
-
A
T
N
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
-
T
E
K
--
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
G
----
K
Y
---------
D
--
L
DFKSPTD
P
----------
S
------
R
---
Y
------
I
--
T
G
-----
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
F
R
N
P
----
117
HHSearch
89.25
50%
-71
- C1 -
2AKZ
6
ENOG_HUMAN
A:
[1-429]
----
S
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
---
I
----
A
---
Q
L
-----
A
GNS--
D
---
L
-----
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
-
D
K
--
Y
GK
D
-
A
T
N
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
-
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
G
----
K
Y
---------
D
--
L
-------
D
FKSPTDP---
S
------
R
---
Y
------
I
--
T
G
-----
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
T
V
-
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
F
R
N
P
----
60
PsiBlast_CBE
89.15
49%
-75
- C1 -
3UJE
4
ENOG_HUMAN
A:
[2-422]
-----
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
----
A
---
G
N
-----
S
-----
D
---
L
-----
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
-
D
K
YG
K
--
D
-
A
T
N
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
-
T
E
K
--
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
G
----
K
Y
---------
D
--
L
DFKSPTD
P
----------
S
------
R
---
Y
------
I
--
T
G
-----
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
F
R
N
P
----
56
PsiBlast_CBE
88.96
49%
-77
- C1 -
3UJR
4
ENOG_HUMAN
A:
[2-422]
-----
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
----
A
---
G
N
-----
S
-----
D
---
L
-----
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
-
D
K
YG
K
--
D
-
A
T
N
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
-
T
E
K
--
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
G
----
K
Y
---------
D
--
L
DFKSPTD
P
----------
S
------
R
---
Y
------
I
--
T
G
-----
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
F
R
N
P
----
51
PsiBlast_CBE
88.95
49%
-74
- C1 -
3UCD
3
ENOG_HUMAN
B:
[2-422]
-----
I
Q
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
IAQ
L
----
A
---
G
N
-----
S
-----
D
---
L
-----
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
-
D
K
YG
K
--
D
-
A
T
N
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
-
T
E
K
--
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
G
----
K
Y
---------
D
--
L
DFKSPTD
P
----------
S
------
R
---
Y
------
I
--
T
G
-----
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
F
R
N
P
----
96
PsiBlast_CBE
88.94
49%
-72
- C1 -
2AL2
5
ENO1_YEAST
B:
[2-425]
-----
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
D
--
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
D
V
P
L
Y
K
H
---
L
----
A
---
D
L
-----
S
-----
K
---
S
KTSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
-----
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
YG
A
--
S
-
A
G
N
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
G
K
--
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
G
----
K
Y
---------
D
LD
F
-------
K
----------
N
PNSDKS
K
---
W
------
L
--
T
G
-----
P
Q
L
A
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
H
G
----
58
PsiBlast_CBE
88.84
49%
-74
- C1 -
3UJF
3
ENOG_HUMAN
A:
[2-422]
-----
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
----
A
---
G
N
-----
S
-----
D
---
L
-----
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
-
D
K
YG
K
--
D
-
A
T
N
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
-
T
E
K
--
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
G
----
K
Y
---------
D
--
L
DFKSPTD
P
----------
S
------
R
---
Y
------
I
--
T
G
-----
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
F
R
N
P
----
85
PsiBlast_CBE
88.52
49%
-72
- C1 -
1ELS
3
ENO1_YEAST
A:
[2-425]
-----
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
S
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
----
A
---
D
L
-----
S
-----
K
---
S
KTSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
YG
A
--
S
-
A
G
N
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
G
K
--
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
G
----
K
Y
---------
D
LD
F
-------
K
----------
N
PNSDKS
K
---
W
------
L
--
T
G
-----
P
Q
L
A
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
H
G
----
52
PsiBlast_CBE
88.31
49%
-75
- C1 -
3UCC
3
ENOG_HUMAN
B:
[2-422]
-----
I
Q
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
IAQ
L
----
A
---
G
N
-----
S
-----
D
---
L
-----
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
-
D
K
YG
K
--
D
-
A
T
N
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
-
T
E
K
--
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
G
----
K
Y
---------
D
--
L
DFKSPTD
P
----------
S
------
R
---
Y
------
I
--
T
G
-----
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
F
R
N
P
----
55
PsiBlast_CBE
88.03
49%
-76
- C1 -
3UJR
3
ENOG_HUMAN
B:
[2-422]
-----
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
IAQ
L
----
A
---
G
N
-----
S
-----
D
---
L
-----
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
-
D
K
YG
K
--
D
-
A
T
N
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
-
T
E
K
--
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
G
----
K
Y
---------
D
--
L
DFKSPTD
P
----------
S
------
R
---
Y
------
I
--
T
G
-----
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
F
R
N
P
----
57
PsiBlast_CBE
87.89
49%
-74
- C1 -
3UJF
3
ENOG_HUMAN
B:
[2-422]
-----
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
IAQ
L
----
A
---
G
N
-----
S
-----
D
---
L
-----
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
-
D
K
YG
K
--
D
-
A
T
N
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
-
T
E
K
--
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
G
----
K
Y
---------
D
--
L
DFKSPTD
P
----------
S
------
R
---
Y
------
I
--
T
G
-----
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
F
R
N
P
----
91
PsiBlast_CBE
87.87
49%
-71
- C1 -
1ONE
3
ENO1_YEAST
A:
[2-425]
-----
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
----
A
---
D
L
-----
S
-----
K
---
S
KTSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
YG
A
--
S
-
A
G
N
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
G
K
--
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
G
----
K
Y
---------
D
LD
F
-------
K
----------
N
PNSDKS
K
---
W
------
L
--
T
G
-----
P
Q
L
A
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
H
G
----
18
PsiBlast_PDB
87.87
49%
-73
- C1 -
3UCD
3
ENOG_HUMAN
A:
[2-422]
-----
I
Q
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
----
A
---
G
N
-----
S
-----
D
---
L
-----
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
-
D
K
YG
K
--
D
-
A
T
N
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
-
T
E
K
--
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
G
----
K
Y
---------
D
--
L
DFKSPTD
P
----------
S
------
R
---
Y
------
I
--
T
G
-----
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
F
R
N
P
----
89
PsiBlast_CBE
87.83
49%
-69
- C1 -
2AL1
3
ENO1_YEAST
A:
[2-425]
-----
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
----
A
---
D
L
-----
S
-----
K
---
S
KTSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
YG
A
--
S
-
A
G
N
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
G
K
--
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
G
----
K
Y
---------
D
LD
F
-------
K
----------
N
PNSDKS
K
---
W
------
L
--
T
G
-----
P
Q
L
A
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
H
G
----
113
HHSearch
87.77
51%
-69
- C1 -
2AL1
3
ENO1_YEAST
A:
[1-432]
----
A
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
-----------
F
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
A
N
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
----
A
---
D
L
-----
S
KSKTS
P
---
Y
-----
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
--
Y
GA
S
-
A
G
N
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
---
D
G
K
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
G
----
K
Y
---------
D
--
L
-------
D
FKNPNSDK--
S
------
K
---
W
------
L
--
T
G
-----
P
Q
L
A
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
--
G
I
Q
I
V
A
D
D
-
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
H
G
----
59
PsiBlast_CBE
87.75
49%
-73
- C1 -
3UJE
3
ENOG_HUMAN
B:
[2-422]
-----
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
IAQ
L
----
A
---
G
N
-----
S
-----
D
---
L
-----
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
-
D
K
YG
K
--
D
-
A
T
N
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
-
T
E
K
--
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
G
----
K
Y
---------
D
--
L
DFKSPTD
P
----------
S
------
R
---
Y
------
I
--
T
G
-----
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
F
R
N
P
----
53
PsiBlast_CBE
87.67
49%
-75
- C1 -
3UJS
3
ENOG_HUMAN
B:
[2-422]
-----
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
IAQ
L
----
A
---
G
N
-----
S
-----
D
---
L
-----
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
-
D
K
YG
K
--
D
-
A
T
N
V
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
-
T
E
K
--
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
--
D
G
----
K
Y
---------
D
--
L
DFKSPTD
P
----------
S
------
R
---
Y
------
I
--
T
G
-----
D
Q
L
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
-
L
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
F
R
N
P
----
88
PsiBlast_CBE
87.29
49%
-72
- C1 -
2AL1
6
ENO1_YEAST
B:
[2-425]
-----
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
----
A
---
D
L
-----
S
-----
K
---
S
KTSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
-----
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
YG
A
--
S
-
A
G
N
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
G
K
--
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
G
----
K
Y
---------
D
LD
F
-------
K
----------
N
PNSDKS
K
---
W
------
L
--
T
G
-----
P
Q
L
A
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
H
G
----
98
PsiBlast_CBE
87.21
49%
-68
- C1 -
1P48
3
ENO1_YEAST
A:
[2-425]
-----
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
----
A
---
D
L
-----
S
-----
K
---
S
KTSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
YG
A
--
S
-
A
G
N
V
G
D
Q
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
G
K
--
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
G
----
K
Y
---------
D
LD
F
-------
K
----------
N
PNSDKS
K
---
W
------
L
--
T
G
-----
P
Q
L
A
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
H
G
----
81
PsiBlast_CBE
87.20
49%
-71
- C1 -
5ENL
2
ENO1_YEAST
A:
[2-425]
-----
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
S
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
----
A
---
D
L
-----
S
-----
K
---
S
KTSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
YG
A
--
S
-
A
G
N
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
G
K
--
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
G
----
K
Y
---------
D
LD
F
-------
K
----------
N
PNSDKS
K
---
W
------
L
--
T
G
-----
P
Q
L
A
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
H
G
----
99
PsiBlast_CBE
87.07
49%
-71
- C1 -
1P43
3
ENO1_YEAST
B:
[2-425]
-----
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
KA
N
--
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
----
A
---
D
L
-----
S
-----
K
---
S
KTSPY
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
Q
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
YG
A
--
S
-
A
G
N
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
G
K
--
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
G
----
K
Y
---------
D
LD
F
-------
K
----------
N
PNSDKS
K
---
W
------
L
--
T
G
-----
P
Q
L
A
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
H
G
----
100
PsiBlast_CBE
87.00
49%
-70
- C1 -
1P43
3
ENO1_YEAST
A:
[2-425]
-----
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
----
A
---
D
L
-----
S
-----
K
---
S
KTSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
Q
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
YG
A
--
S
-
A
G
N
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
G
K
--
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
G
----
K
Y
---------
D
LD
F
-------
K
----------
N
PNSDKS
K
---
W
------
L
--
T
G
-----
P
Q
L
A
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
H
G
----
97
PsiBlast_CBE
86.99
49%
-69
- C1 -
1P48
3
ENO1_YEAST
B:
[2-425]
-----
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
KA
N
--
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
----
A
---
D
L
-----
S
-----
K
---
S
KTSPY
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
YG
A
--
S
-
A
G
N
V
G
D
Q
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
G
K
--
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
G
----
K
Y
---------
D
LD
F
-------
K
----------
N
PNSDKS
K
---
W
------
L
--
T
G
-----
P
Q
L
A
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
H
G
----
87
PsiBlast_CBE
86.88
49%
-69
- C1 -
2ONE
3
ENO1_YEAST
A:
[2-425]
-----
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
----
A
---
D
L
-----
S
-----
K
---
S
KTSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
YG
A
--
S
-
A
G
N
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
G
K
--
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
G
----
K
Y
---------
D
LD
F
-------
K
----------
N
PNSDKS
K
---
W
------
L
--
T
G
-----
P
Q
L
A
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
H
G
----
95
PsiBlast_CBE
86.61
49%
-69
- C1 -
1EBG
3
ENO1_YEAST
A:
[2-425]
-----
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
----
A
---
D
L
-----
S
-----
K
---
S
KTSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
YG
A
--
S
-
A
G
N
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
G
K
--
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
G
----
K
Y
---------
D
LD
F
-------
K
----------
N
PNSDKS
K
---
W
------
L
--
T
G
-----
P
Q
L
A
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
H
G
----
94
PsiBlast_CBE
86.46
49%
-68
- C1 -
1EBG
3
ENO1_YEAST
B:
[2-425]
-----
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
KA
N
--
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
----
A
---
D
L
-----
S
-----
K
---
S
KTSPY
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
YG
A
--
S
-
A
G
N
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
G
K
--
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
G
----
K
Y
---------
D
LD
F
-------
K
----------
N
PNSDKS
K
---
W
------
L
--
T
G
-----
P
Q
L
A
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
H
G
----
90
PsiBlast_CBE
86.44
49%
-70
- C1 -
1ONE
3
ENO1_YEAST
B:
[2-425]
-----
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
KA
N
--
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
----
A
---
D
L
-----
S
-----
K
---
S
KTSPY
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
YG
A
--
S
-
A
G
N
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
G
K
--
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
G
----
K
Y
---------
D
LD
F
-------
K
----------
N
PNSDKS
K
---
W
------
L
--
T
G
-----
P
Q
L
A
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
H
G
----
79
PsiBlast_CBE
86.36
49%
-69
- C1 -
7ENL
2
ENO1_YEAST
A:
[2-425]
-----
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
S
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
----
A
---
D
L
-----
S
-----
K
---
S
KTSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
YG
A
--
S
-
A
G
N
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
G
K
--
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
G
----
K
Y
---------
D
LD
F
-------
K
----------
N
PNSDKS
K
---
W
------
L
--
T
G
-----
P
Q
L
A
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
H
G
----
86
PsiBlast_CBE
86.01
49%
-74
- C1 -
2ONE
2
ENO1_YEAST
B:
[2-425]
-----
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
KA
N
--
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
----
A
---
D
L
-----
S
-----
K
---
S
KTSPY
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
YG
A
--
S
-
A
G
N
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
G
K
--
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
G
----
K
Y
---------
D
LD
F
-------
K
----------
N
PNSDKS
K
---
W
------
L
--
T
G
-----
P
Q
L
A
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
H
G
----
80
PsiBlast_CBE
85.30
49%
-71
- C1 -
6ENL
2
ENO1_YEAST
A:
[2-425]
-----
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
S
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
----
A
---
D
L
-----
S
-----
K
---
S
KTSP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
YG
A
--
S
-
A
G
N
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
G
K
--
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
G
----
K
Y
---------
D
LD
F
-------
K
----------
N
PNSDKS
K
---
W
------
L
--
T
G
-----
P
Q
L
A
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
-
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
H
G
----
101
Fugue
85.16
50%
-70
- C1 -
1ONE
3
ENO1_YEAST
A:
[1-436]
----
A
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
-----------
V
F
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
A
N
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
----
A
---
D
L
S
KSKT
S
-----
P
---
Y
-----
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
-
K
R
YG
A
--
S
-
A
G
N
V
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
-
D
--
G
K
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
--
D
-----
G
K
Y
D
LDFKNPN
S
--
D
-------
K
----------
S
------
K
---
W
------
L
--
T
G
-----
P
Q
L
A
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
--
A
G
I
Q
I
V
A
D
D
-
L
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
-
G
E
N
F
H
H
GDKL
78
PsiBlast_CBE
84.68
49%
-69
- C1 -
3QTP
6
ENO1_ENTHI
A:
[8-426]
-----
I
Q
K
V
H
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
I
T
T
G
K
G
M
----------
F
-
R
S
C
V
P
S
G
A
S
T
G
V
H
E
A
V
E
L
R
D
G
D
K
K
R
Y
G
G
K
G
V
L
K
A
V
E
N
V
N
T
I
I
G
P
A
L
L
--
G
--
K
N
V
L
N
Q
A
E
L
D
E
M
M
I
K
L
D
G
T
N
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
S
I
C
R
A
A
A
A
E
K
G
L
P
L
Y
K
Y
---
L
----
A
E
L
T
G
H
-----
K
-----
E
---
M
-----
T
M
P
V
P
C
F
N
V
I
N
G
G
A
H
A
G
N
A
L
A
M
Q
E
F
M
I
C
P
T
G
A
T
N
F
H
E
A
L
R
M
A
A
E
T
Y
Q
C
----
L
K
V
V
I
K
A
K
Y
--
G
--
Q
D
A
T
N
V
G
D
E
G
G
F
A
P
N
V
S
G
A
R
E
A
L
D
L
L
V
E
A
I
A
K
A
G
Y
-
T
G
K
--
I
E
I
A
M
D
C
A
A
S
E
F
Y
--
N
--
E
E
----
T
K
---------
K
--
Y
DLGKKIP
A
----------
D
------
K
---
K
------
D
--
P
S
LVKD
V
D
G
L
I
A
E
Y
V
D
Y
G
K
H
Y
P
I
A
S
I
E
D
P
F
A
E
D
D
W
A
A
W
N
K
F
T
V
E
H
G
N
-
F
Q
I
V
G
D
D
-
L
L
V
T
N
P
A
R
V
Q
M
A
M
D
K
N
A
C
N
S
V
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
K
T
I
K
M
A
Q
E
K
G
W
G
V
M
A
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
N
C
K
Q
I
K
T
G
A
P
C
R
S
E
R
L
C
K
Y
N
Q
L
M
R
I
E
E
E
L
G
N
I
P
Y
A
G
K
N
W
R
N
S
T
----
120
HHSearch
84.64
48%
-71
- C1 -
3QTP
6
ENO1_ENTHI
A:
[4-439]
-
G
S
M
S
I
Q
K
V
H
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
I
T
T
G
K
G
M
F
R
S
C
V
P
S
GAS
T
G
V
H
E
A
V
E
L
-----------
R
D
G
D
K
K
R
Y
G
G
K
G
V
L
K
A
V
E
N
V
N
T
I
I
G
P
A
L
L
--
G
--
K
N
V
L
N
Q
A
E
L
D
E
M
M
I
K
L
D
G
T
N
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
S
I
C
R
A
A
A
A
E
K
G
L
P
L
Y
K
Y
---
L
----
A
---
E
L
-----
T
-----
G
HK
E
M
-----
T
M
P
V
P
C
F
N
V
I
N
G
G
A
H
A
G
N
A
L
A
M
Q
E
F
M
I
C
P
T
G
A
T
N
F
H
E
A
L
R
M
A
A
E
T
Y
Q
C
----
L
K
V
V
I
K
-
A
K
--
Y
GQ
D
-
A
T
N
V
G
D
E
G
G
F
A
P
N
V
S
G
A
R
E
A
L
D
L
L
V
E
A
I
A
K
A
G
Y
---
T
G
K
I
E
I
A
M
D
C
A
A
S
E
F
Y
--
N
EE
T
K
----
K
Y
---------
D
--
L
-------
G
KKIPADKKDP
S
------
L
---
V
------
K
--
D
V
-----
D
G
L
I
A
E
Y
V
D
Y
G
K
H
Y
P
I
A
S
I
E
D
P
F
A
E
D
D
W
A
A
W
N
K
F
T
V
E
H
G
-
N
F
Q
I
V
G
D
D
-
L
L
V
T
N
P
A
R
V
Q
M
A
M
D
K
N
A
C
N
S
V
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
K
T
I
K
M
A
Q
E
K
G
W
G
V
M
A
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
N
C
K
Q
I
K
T
G
A
P
C
R
S
E
R
L
C
K
Y
N
Q
L
M
R
I
E
E
E
L
G
N
-
I
P
Y
A
G
K
N
W
R
N
S
----
77
PsiBlast_CBE
83.81
49%
-71
- C1 -
3QTP
6
ENO1_ENTHI
B:
[8-426]
-----
I
Q
K
V
H
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
I
T
T
G
K
G
M
----------
F
-
R
S
C
V
P
S
G
A
S
T
G
V
H
E
A
V
E
L
R
D
G
D
K
K
R
Y
G
G
K
G
V
L
K
A
V
E
N
V
N
T
I
I
G
P
A
L
L
--
G
--
K
N
V
L
N
Q
A
E
L
D
E
M
M
I
K
L
D
G
T
N
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
S
I
C
R
A
A
A
A
E
K
G
L
P
L
Y
K
Y
---
L
----
A
E
L
T
G
H
-----
K
-----
E
---
M
-----
T
M
P
V
P
C
F
N
V
I
N
G
G
A
H
A
G
N
A
L
A
M
Q
E
F
M
I
C
P
T
G
A
T
N
F
H
E
A
L
R
M
A
A
E
T
Y
Q
C
----
L
K
V
V
I
K
A
K
Y
--
G
--
Q
D
A
T
N
V
G
D
E
G
G
F
A
P
N
V
S
G
A
R
E
A
L
D
L
L
V
E
A
I
A
K
A
G
Y
-
T
G
K
--
I
E
I
A
M
D
C
A
A
S
E
F
Y
--
N
--
E
E
----
T
K
---------
K
--
Y
DLGKKIP
A
----------
D
------
K
---
K
------
D
--
P
S
LVKD
V
D
G
L
I
A
E
Y
V
D
Y
G
K
H
Y
P
I
A
S
I
E
D
P
F
A
E
D
D
W
A
A
W
N
K
F
T
V
E
H
G
N
-
F
Q
I
V
G
D
D
-
L
L
V
T
N
P
A
R
V
Q
M
A
M
D
K
N
A
C
N
S
V
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
K
T
I
K
M
A
Q
E
K
G
W
G
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A
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H
R
S
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E
D
T
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L
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V
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L
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C
K
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A
P
C
R
S
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R
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M
R
I
E
E
E
L
G
N
I
P
Y
A
G
K
N
W
R
N
S
T
----
121
HHSearch
82.98
47%
-68
- C1 -
2PTZ
5
?
A:
[2-429]
-
S
H
M
T
I
Q
K
V
H
G
R
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L
D
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G
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AS
T
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Y
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A
C
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L
-----------
R
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K
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C
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N
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A
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--
G
--
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E
E
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D
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L
M
L
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T
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N
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A
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A
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G
C
S
M
A
I
S
K
A
A
A
A
A
K
G
V
P
L
Y
R
Y
---
L
----
A
---
S
L
-----
A
GTK--
E
---
L
-----
R
L
P
V
P
C
F
N
V
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N
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G
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G
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A
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I
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K
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Y
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-
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------
D
-
A
V
N
V
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D
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G
G
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A
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A
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---
H
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M
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C
A
A
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Y
--
D
EK
K
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----
Q
Y
---------
N
--
L
-------
T
FKSP
E
-----
P
------
T
---
W
------
V
--
T
A
-----
E
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L
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Y
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-
L
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L
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A
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W
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A
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L
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V
A
L
G
S
G
Q
I
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A
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C
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G
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R
T
A
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L
N
Q
L
L
R
I
E
E
E
L
G
A
H
A
K
F
G
F
P
G
W
S
------