@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0138: (2015-11-28 )
MMELKMHNVKGTENLKFDAEVGKVLNIVIHSLYTNKDIFLRELVSNASDACDKLRYESQLNPNLLDSSGELKITISSNKDENELYVTDNGIGMSRQDLIGNLGTIASSGTQKFLDAIKNSKDSSQAVELIGKFGVGFYSSFMVASEVIVESRKAGEEESWVWRSTGDGEYSISKLDNQIPCGTKITLVMRPEENEFLDKFRIENIVTTYSDHINFPVEFIDEEGKSEKLNSKAAIWTKLKNDVTQEEHNDFFRGVAHVGGEPWMILHNKNEGAIEYTNLLYVPSIKPFDLFHPDRRCSVKLYVNKVFITEDNVQIIPQYLRFLKGVVDSPDLPLNISRETLQNNRVVEQIRKSLTKRVISELGKKAKENLEEYTKFWTNFGAVLKEGLCEAMPTEEREALLSICRFHSTGDKKLVSIDDYISRMKPEQGYIYYLTGNSLDSVKNSPQLEGFISKGLEVLLFVDPVDDFWTSVIHEYKGQKFKSVTRADVDLEKFSPEEKDKENKSDEERAEGNTDSILQYFTKVLGNAVKSVKISKKLTDSPVCLAVDEGAMDLRMERFLREQNQLNYRTPKVLEVNTKHSVIKSIIKSYAENGENPTLEDMVHLLFYQACIVEGEEMDDASLFAKKLNNLLGKVII
Atome Classification :
(21 SA)
.........-10-.....-------...20........30........40........50........60........70--.........80........90........100.......110.......120.......130.......140.......150..-..--.--.-.160.......170--.-..--.--...180.......190.......200.......210.......220..-.--------..-------...230.......240.......250.......260.......270.......280.....-..290....--...300.......310.......320.......330.......340.......350.......360.......370.-......380.......390.......-400.......410-.-..-......420.......430.......440.......450.......460.......470.......480.......490.......500.......-510.......520-.-......530.......540.......-550.--......560..-------..---------...---------570-........580.......590..-.....600.......610.......620.......630.....-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
M
E
L
K
MHNV-KG-TEN
L
K
-------
F
D
A
E
V
G
K
V
L
N
I
V
I
H
S
LYTN
K
D
I
F
L
R
E
L
V
SN
A
S
D
A
C
D
K
L
R
Y
ESQLNPNLLDSSG
E
---
L
K
I
T
I
SSNKDE
N
E
L
Y
V
TDNGIGM
S
R
Q
D
L
I
GN
L
G
T
IASS
G
T
Q
K
F
L
D
A
I
KNSKD
S
S
Q
A
V
E
L
I
G
K
F
G
V
G
F
Y
S
S
F
M
V
A
S
E
V
I
V
E
S
RKA-GE--E--E-
S
W
V
W
R
STGDGEY
S
I
--
S
-
K
L--D--NQIPCG
T
K
I
T
L
V
MRPE
E
N
E
F
L
D
K
F
R
I
E
N
I
V
T
T
Y
SDHINF
P
V
E
F
I-DEE-G--------KS-------EKLNS
K
A
A
I
W
T
K
L
KNDV
T
Q
E
E
H
N
D
F
F
R
G
V
A
HVGGE
P
W
M
I
L
HNKNEG
A
I
E
Y
T
N
L
L
YVPSIK
P
-
F
DLFHPDR
R
--
C
S
V
K
L
Y
V
N
K
V
F
ITED
N
V
Q
I
I
P
Q
Y
L
R
F
L
K
G
VVDSPDLPLN
I
S
R
E
T
LQN
N
R
V
V
E
Q
I
R
K
S
L
T
K
R
V
I
S
E
L
G
K
K
A
K
E
N
L
E
E
Y
-
T
K
F
W
T
N
F
G
A
V
L
K
E
G
L
C
E
AMP
T
E
E
R
E
A
-
L
L
S
I
C
R
FHSTG---D-
K
K
-
L
V
S
I
D
D
Y
I
S
RMKPEQ
G
Y
I
Y
Y
LTGN
S
L
D
SVKN
S
P
Q
L
E
G
F
I
SKG
L
E
V
L
L
F
VD
P
V
D
D
F
W
T
S
V
I
H
E
YKG
Q
K
F
K
S
V
T
RADV
D
L
E
KFSPEEKDKENKS
D
E
E
R-AEG
N
T
D
S
I
L
Q
Y
F
T
-
K
-
V
L
G
N
A
V
K
S
V
K
ISKKLTDS
P
V
C
L
A
VDE-G
A
M
D
--
L
R
M
E
R
F
L
R
E
Q
N-------QL---------NYR---------T
P
--
K
V
L
E
VN
T
K
H
S
V
I
K
S
I
I
K
S
Y
A
ENG-ENP
T
L
E
D
M
V
H
L
L
F
Y
Q
A
C
IVEGEEMD
D
A
S
L
F
A
K
K
L
N
N
L
L
G
KVII-
21
PsiBlast_CBE
89.19
41%
-80
- C2 -
2IOP
1
HTPG_ECOLI
D:
[1-622]
--------
M
-
K
G
-
Q
E
T
R
G
-------
F
Q
S
E
V
K
Q
L
L
H
L
M
I
H
S
L
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
A
D
K
L
R
F
R
A
L
S
N
P
D
L
Y
E
G
D
G
E
---
L
R
V
R
V
S
F
D
K
D
K
R
T
L
T
I
S
D
N
G
V
G
M
T
R
D
E
V
I
D
H
L
G
T
I
A
K
S
G
T
K
S
F
L
E
S
L
--
G
S
D
Q
A
K
D
S
Q
L
I
G
Q
F
G
V
G
F
Y
S
A
F
I
V
A
D
K
V
T
V
R
T
R
A
A
-
G
E
KP
E
--
N
-
G
V
F
W
E
S
A
G
E
G
E
Y
T
V
--
A
-
D
I
--
T
--
K
E
-
D
R
G
T
E
I
T
L
H
L
R
E
G
E
D
E
F
L
D
D
W
R
V
R
S
I
I
S
K
Y
S
D
H
I
A
L
P
V
E
I
E
-
K
R
E
-
E
--------
K
D
T
V
I
S
W
--
E
K
I
N
K
A
Q
A
L
W
T
R
N
K
S
E
I
T
D
E
E
Y
K
E
F
Y
K
H
I
A
H
D
F
N
D
P
L
T
W
S
H
N
R
V
E
G
K
Q
E
Y
T
S
L
L
Y
I
P
S
Q
A
P
-
W
D
M
W
N
R
-
H
K
--
H
G
L
K
L
Y
V
Q
R
V
F
I
M
D
D
A
E
Q
F
M
P
N
Y
L
R
F
V
R
G
L
I
D
S
S
D
L
P
L
N
V
S
R
E
I
L
Q
D
S
T
V
T
R
N
L
R
N
A
L
T
K
R
V
L
Q
M
L
E
K
L
A
K
D
D
A
E
K
Y
-
Q
T
F
W
Q
Q
F
G
L
V
L
K
E
G
P
A
E
D
F
A
N
Q
E
A
I
A
K
L
L
R
F
A
S
T
H
T
D
S
---
S
-
A
Q
-
T
V
S
L
E
D
Y
V
S
R
M
K
E
G
Q
E
K
I
Y
Y
I
T
A
D
S
Y
A
A
A
K
S
S
P
H
L
E
L
L
R
K
K
G
I
E
V
L
L
L
S
D
R
I
D
E
W
M
M
N
Y
L
T
E
F
D
G
K
P
F
Q
S
V
S
K
V
D
E
S
L
E
K
L
-----------------------
F
I
D
R
V
K
-
A
-
L
L
G
E
R
V
K
D
V
R
L
T
H
R
L
T
D
T
P
A
I
V
S
T
D
A
-
D
E
M
S
--
T
Q
M
A
K
L
F
A
A
A
G
-------
Q
K
---------
V
P
E
---------
V
K
--
Y
I
F
E
L
N
P
D
H
----
V
L
V
K
R
A
A
D
T
E
-
D
E
A
K
F
S
E
W
V
E
L
L
L
D
Q
A
L
L
A
E
R
G
T
L
E
D
P
N
L
F
I
R
R
M
N
Q
L
L
V
S
----
23
PsiBlast_CBE
87.81
35%
-81
- C2 -
2O1V
3
ENPL_CANFA
B:
[36-655]
----------------------------------
K
L
I
I
N
S
L
Y
K
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
L
I
S
L
T
D
E
N
A
L
A
G
N
E
E
---
L
T
V
K
I
K
C
D
K
E
K
N
L
L
H
V
T
D
T
G
V
G
M
T
R
E
E
L
V
K
N
L
G
T
------------------------------
V
G
F
Y
S
A
F
L
V
A
D
K
V
I
V
T
S
K
H
N
-
N
D
--
T
--
Q
-
H
-
I
W
E
S
D
S
N
-
E
F
S
V
I
A
D
-
P
R
--
G
--
N
T
L
G
R
G
T
T
I
T
L
V
L
K
E
E
A
S
D
Y
L
E
L
D
T
I
K
N
L
V
K
K
Y
S
Q
F
I
N
F
P
I
Y
V
W
-
S
S
K
T-----------V
W
D
W
---
E
L
M
N
D
I
K
P
I
W
Q
R
P
S
K
E
V
E
D
D
E
Y
K
A
F
Y
K
S
F
S
K
E
S
D
D
P
M
A
Y
I
H
F
T
A
E
G
E
V
T
F
K
S
I
L
F
V
P
T
S
A
--------------
Y
I
K
L
Y
V
R
R
V
F
I
T
D
D
F
H
D
M
M
P
K
Y
L
N
F
V
K
G
V
V
D
S
D
D
L
P
L
N
V
S
R
E
T
L
Q
Q
H
K
L
L
K
V
I
R
K
K
L
V
R
K
T
L
D
M
I
K
K
I
A
D
E
K
Y
N
D
---
T
F
W
K
E
F
G
T
N
I
K
L
G
V
I
E
D
H
S
N
R
T
R
---
L
A
K
L
L
R
F
Q
S
S
H
---
H
-
P
S
D
I
T
S
L
D
Q
Y
V
E
R
M
K
E
K
Q
D
K
I
Y
F
M
A
G
S
S
R
K
E
A
E
S
S
P
F
V
E
R
L
L
K
K
G
Y
E
V
I
Y
L
T
E
P
V
D
E
Y
C
I
Q
A
L
P
E
F
D
G
K
R
F
Q
N
V
A
K
E
G
V
---
K
F
D
E
S
E
K
T
K
E
S
R
---
E
A
-
I
E
K
E
F
E
P
L
L
N
W
M
K
D
K
-
A
L
K
D
K
I
E
K
A
V
V
S
Q
R
L
T
E
S
P
C
A
L
V
A
S
Q
-
Y
G
W
S
--
G
N
M
E
R
I
M
K
A
Q
A
Y
Q
TGKDI
S
T
---------
N
Y
Y
---------
A
S
QK
K
T
F
E
I
N
P
R
H
P
L
I
K
D
M
L
R
R
V
K
E
D
E
-
D
D
K
T
V
S
D
L
A
V
V
L
F
E
T
A
T
L
R
S
G
Y
L
L
P
D
T
K
A
Y
G
D
R
I
E
R
M
L
R
L
S
L
N
-
103
HHSearch
87.60
42%
-80
- C2 -
2IOQ
-
HTPG_ECOLI
A:
[15-624]
-------------------------------
Q
L
L
H
L
M
I
H
S
L
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
A
D
K
L
R
F
R
A
L
S
N
P
D
L
Y
E
G
D
G
E
---
L
R
V
R
V
S
F
D
K
D
K
R
T
L
T
I
S
D
N
G
V
G
M
T
R
D
E
V
I
D
H
L
G
T
I
A
K
-----------------
K
D
S
Q
L
I
G
Q
F
G
V
G
F
Y
S
A
F
I
V
A
D
K
V
T
V
R
T
R
A
A
-
G
E
KP
E
--
N
-
G
V
F
W
E
S
A
G
E
G
E
Y
T
V
--
A
-
D
I
--
T
---
K
E
D
R
G
T
E
I
T
L
H
L
R
E
G
E
D
E
F
L
D
D
W
R
V
R
S
I
I
S
K
Y
S
D
H
I
A
L
P
V
E
I
E
-
K
R
E
-
E
K
DGET
V
I
-
S
W
-------
E
K
I
N
K
A
Q
A
L
W
T
R
N
K
S
E
I
T
D
E
E
Y
K
E
F
Y
K
H
I
A
H
D
F
N
D
P
L
T
W
S
H
N
R
V
E
G
K
Q
E
Y
T
S
L
L
Y
I
P
S
Q
A
P
-
W
D
M
W
N
R
D
H
K
--
H
G
L
K
L
Y
V
Q
R
V
F
I
M
D
D
A
E
Q
F
M
P
N
Y
L
R
F
V
R
G
L
I
D
S
S
D
L
P
L
N
V
S
R
E
I
L
Q
D
S
T
V
T
R
N
L
R
N
A
L
T
K
R
V
L
Q
M
L
E
K
L
A
K
D
D
A
E
K
Y
-
Q
T
F
W
Q
Q
F
G
L
V
L
K
E
G
P
A
E
D
-
F
-
A
N
Q
E
A
-
I
A
K
L
L
R
F
A
S
T
H
TDS
S
-
A
Q
-
T
V
S
L
E
D
Y
V
S
R
M
K
E
G
Q
E
K
I
Y
Y
I
T
A
D
S
Y
A
A
A
K
S
S
P
H
L
E
L
L
R
K
K
G
I
E
V
L
L
L
S
D
R
I
D
E
W
M
M
N
Y
L
T
E
F
D
G
K
P
F
Q
S
V
S
K
V
D
E
S
L
E
K
--
L
A
----------
K
E
-
A
E
K
A
L
T
P
F
I
D
R
V
K
-
A
-
L
L
G
E
R
V
K
D
V
R
L
T
H
R
L
T
D
T
P
A
I
V
S
T
D
A
-------------------------------------------------
K
--
Y
I
F
E
L
N
P
D
H
V
L
V
K
R
A
A
D
T
E
D
-----
E
A
K
F
S
E
W
V
E
L
L
L
D
Q
A
L
L
A
E
R
G
T
L
E
D
P
N
L
F
I
R
R
M
N
Q
L
L
V
S
----
1
PsiBlast_PDB
87.12
41%
-80
- C2 -
2IOQ
-
HTPG_ECOLI
A:
[15-622]
-------------------------------
Q
L
L
H
L
M
I
H
S
L
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
A
D
K
L
R
F
R
A
L
S
N
P
D
L
Y
E
G
D
G
E
---
L
R
V
R
V
S
F
D
K
D
K
R
T
L
T
I
S
D
N
G
V
G
M
T
R
D
E
V
I
D
H
L
G
T
I
A
K
-----------------
K
D
S
Q
L
I
G
Q
F
G
V
G
F
Y
S
A
F
I
V
A
D
K
V
T
V
R
T
R
A
A
-
G
E
KP
E
--
N
-
G
V
F
W
E
S
A
G
E
G
E
Y
T
V
--
A
-
D
I
--
T
--
K
E
-
D
R
G
T
E
I
T
L
H
L
R
E
G
E
D
E
F
L
D
D
W
R
V
R
S
I
I
S
K
Y
S
D
H
I
A
L
P
V
E
I
E
-
K
R
E
-
E
--------
K
D
GET
V
I
S
W
E
K
I
N
K
A
Q
A
L
W
T
R
N
K
S
E
I
T
D
E
E
Y
K
E
F
Y
K
H
I
A
H
D
F
N
D
P
L
T
W
S
H
N
R
V
E
G
K
Q
E
Y
T
S
L
L
Y
I
P
S
Q
A
P
-
W
D
M
W
N
R
D
H
K
--
H
G
L
K
L
Y
V
Q
R
V
F
I
M
D
D
A
E
Q
F
M
P
N
Y
L
R
F
V
R
G
L
I
D
S
S
D
L
P
L
N
V
S
R
E
I
L
Q
D
S
T
V
T
R
N
L
R
N
A
L
T
K
R
V
L
Q
M
L
E
K
L
A
K
D
D
A
E
K
Y
-
Q
T
F
W
Q
Q
F
G
L
V
L
K
E
G
P
A
E
D
F
A
N
Q
E
A
I
A
K
L
L
R
F
A
S
T
H
T
D
S
---
S
-
A
Q
-
T
V
S
L
E
D
Y
V
S
R
M
K
E
G
Q
E
K
I
Y
Y
I
T
A
D
S
Y
A
A
A
K
S
S
P
H
L
E
L
L
R
K
K
G
I
E
V
L
L
L
S
D
R
I
D
E
W
M
M
N
Y
L
T
E
F
D
G
K
P
F
Q
S
V
S
K
V
D
E
S
L
E
K
L
A
-----------
K
E
--
A
E
K
A
L
T
P
F
I
D
R
V
K
-
A
-
L
L
G
E
R
V
K
D
V
R
L
T
H
R
L
T
D
T
P
A
I
V
S
T
D
A
-------------------------------------------------
K
--
Y
I
F
E
L
N
P
D
H
----
V
L
V
K
R
A
A
D
T
E
-
D
E
A
K
F
S
E
W
V
E
L
L
L
D
Q
A
L
L
A
E
R
G
T
L
E
D
P
N
L
F
I
R
R
M
N
Q
L
L
V
S
----
24
PsiBlast_CBE
86.61
35%
-80
- C2 -
2O1U
3
?
B:
[36-655]
----------------------------------
K
L
I
I
N
S
L
Y
K
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
L
I
S
L
T
D
E
N
A
L
A
G
N
E
E
---
L
T
V
K
I
K
C
D
K
E
K
N
L
L
H
V
T
D
T
G
V
G
M
T
R
E
E
L
V
K
N
L
G
T
------------------------------
V
G
F
Y
S
A
F
L
V
A
D
K
V
I
V
T
S
K
H
N
-
N
D
--
T
--
Q
-
H
-
I
W
E
S
D
S
N
-
E
F
S
V
I
A
D
-
P
R
--
G
--
N
T
L
G
R
G
T
T
I
T
L
V
L
K
E
E
A
S
D
Y
L
E
L
D
T
I
K
N
L
V
K
K
Y
S
Q
F
I
N
F
P
I
Y
V
W
-
S
S
K
T-----------V
W
D
W
---
E
L
M
N
D
I
K
P
I
W
Q
R
P
S
K
E
V
E
D
D
E
Y
K
A
F
Y
K
S
F
S
K
E
S
D
D
P
M
A
Y
I
H
F
T
A
E
G
E
V
T
F
K
S
I
L
F
V
P
T
S
A
--------------
Y
I
K
L
Y
V
R
R
V
F
I
T
D
D
F
H
D
M
M
P
K
Y
L
N
F
V
K
G
V
V
D
S
D
D
L
P
L
N
V
S
R
E
T
L
Q
Q
H
K
L
L
K
V
I
R
K
K
L
V
R
K
T
L
D
M
I
K
K
I
A
D
E
K
Y
N
D
---
T
F
W
K
E
F
G
T
N
I
K
L
G
V
I
E
D
H
S
N
R
T
R
---
L
A
K
L
L
R
F
Q
S
S
H
---
H
-
P
S
D
I
T
S
L
D
Q
Y
V
E
R
M
K
E
K
Q
D
K
I
Y
F
M
A
G
S
S
R
K
E
A
E
S
S
P
F
V
E
R
L
L
K
K
G
Y
E
V
I
Y
L
T
E
P
V
D
E
Y
C
I
Q
A
L
P
E
F
D
G
K
R
F
Q
N
V
A
K
E
G
V
---
K
F
D
E
S
E
K
T
K
E
S
R
---
E
A
-
I
E
K
E
F
E
P
L
L
N
W
M
K
D
K
-
A
L
K
D
K
I
E
K
A
V
V
S
Q
R
L
T
E
S
P
C
A
L
V
A
S
Q
-
Y
G
W
S
--
G
N
M
E
R
I
M
K
A
Q
A
Y
Q
TGKDI
S
T
---------
N
Y
Y
---------
A
S
Q
K
K
T
F
E
I
N
P
R
H
P
L
I
K
D
M
L
R
R
V
K
E
D
E
-
D
D
K
T
V
S
D
L
A
V
V
L
F
E
T
A
T
L
R
S
G
Y
L
L
P
D
T
K
A
Y
G
D
R
I
E
R
M
L
R
L
S
L
N
-
5
PsiBlast_PDB
85.91
35%
-77
- C2 -
2O1V
3
ENPL_CANFA
A:
[34-655]
--------------------------------
M
M
K
L
I
I
N
S
L
Y
K
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
L
I
S
L
T
D
E
N
A
L
A
G
N
E
E
---
L
T
V
K
I
K
C
D
K
E
K
N
L
L
H
V
T
D
T
G
V
G
M
T
R
E
E
L
V
K
N
L
G
T
------------------------------
V
G
F
Y
S
A
F
L
V
A
D
K
V
I
V
T
S
K
H
N
-
N
D
--
T
--
Q
-
H
-
I
W
E
S
D
S
N
-
E
F
S
V
I
A
D
-
P
R
--
G
--
N
T
L
G
R
G
T
T
I
T
L
V
L
K
E
E
A
S
D
Y
L
E
L
D
T
I
K
N
L
V
K
K
Y
S
Q
F
I
N
F
P
I
Y
V
W
-
S
S
K
------------V
W
D
W
---
E
L
M
N
D
I
K
P
I
W
Q
R
P
S
K
E
V
E
D
D
E
Y
K
A
F
Y
K
S
F
S
K
E
S
D
D
P
M
A
Y
I
H
F
T
A
E
G
E
V
T
F
K
S
I
L
F
V
P
T
S
A
P
R------------
Y
I
K
L
Y
V
R
R
V
F
I
T
D
D
F
H
D
M
M
P
K
Y
L
N
F
V
K
G
V
V
D
S
D
D
L
P
L
N
V
S
R
E
T
L
Q
Q
H
K
L
L
K
V
I
R
K
K
L
V
R
K
T
L
D
M
I
K
K
I
A
D
E
K
Y
N
D
---
T
F
W
K
E
F
G
T
N
I
K
L
G
V
I
E
D
H
S
N
R
T
R
---
L
A
K
L
L
R
F
Q
S
S
H
---
H
-
P
S
D
I
T
S
L
D
Q
Y
V
E
R
M
K
E
K
Q
D
K
I
Y
F
M
A
G
S
S
R
K
E
A
E
S
S
P
F
V
E
R
L
L
K
K
G
Y
E
V
I
Y
L
T
E
P
V
D
E
Y
C
I
Q
A
L
P
E
F
D
G
K
R
F
Q
N
V
A
K
E
G
V
---
K
F
D
E
S
E
K
T
K
E
S
R
---
E
A
-
I
E
K
E
F
E
P
L
L
N
W
M
K
D
K
-
A
L
K
D
K
I
E
K
A
V
V
S
Q
R
L
T
E
S
P
C
A
L
V
A
S
Q
-
Y
G
W
S
--
G
N
M
E
R
I
M
K
A
Q
A
Y
Q
TGKDI
S
T
---------
N
Y
Y
---------
A
S
Q
K
K
T
F
E
I
N
P
R
H
P
L
I
K
D
M
L
R
R
V
K
E
D
E
-
D
D
K
T
V
S
D
L
A
V
V
L
F
E
T
A
T
L
R
S
G
Y
L
L
P
D
T
K
A
Y
G
D
R
I
E
R
M
L
R
L
S
L
N
-
101
HHSearch
85.51
35%
-79
- C2 -
2O1U
3
?
A:
[34-659]
--------------------------------
M
M
K
L
I
I
N
S
L
Y
K
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
L
I
S
L
T
D
E
N
A
L
A
G
N
E
E
---
L
T
V
K
I
K
C
D
K
E
K
N
L
L
H
V
T
D
T
G
V
G
M
T
R
E
E
L
V
K
N
L
G
T
------------------------------
V
G
F
Y
S
A
F
L
V
A
D
K
V
I
V
T
S
K
H
N
-
N
D
-----
T
-
Q
H
I
W
E
S
D
S
-
N
E
F
S
V
--
I
-
A
D
PR
G
--
N
T
L
G
R
G
T
T
I
T
L
V
L
K
E
E
A
S
D
Y
L
E
L
D
T
I
K
N
L
V
K
K
Y
S
Q
F
I
N
F
P
I
Y
V
W
-
S
S
K
--V
W
------
D
W
-------
E
L
M
N
D
I
K
P
I
W
Q
R
P
S
K
E
V
E
D
D
E
Y
K
A
F
Y
K
S
F
S
K
E
S
D
D
P
M
A
Y
I
H
F
T
A
E
G
E
V
T
F
K
S
I
L
F
V
P
T
S
A
P
-
R
-----------
Y
I
K
L
Y
V
R
R
V
F
I
T
D
D
F
H
D
M
M
P
K
Y
L
N
F
V
K
G
V
V
D
S
D
D
L
P
L
N
V
S
R
E
T
L
Q
Q
H
K
L
L
K
V
I
R
K
K
L
V
R
K
T
L
D
M
I
K
K
I
A
D
---
E
K
Y
N
D
T
F
W
K
E
F
G
T
N
I
K
L
G
V
I
E
D
H
--
S
N
R
T
R
-
L
A
K
L
L
R
F
Q
S
S
H
---
H
P
S
D
-
I
T
S
L
D
Q
Y
V
E
R
M
K
E
K
Q
D
K
I
Y
F
M
A
G
S
S
R
K
E
A
E
S
S
P
F
V
E
R
L
L
K
K
G
Y
E
V
I
Y
L
T
E
P
V
D
E
Y
C
I
Q
A
L
P
E
F
D
G
K
R
F
Q
N
V
A
K
E
G
V
K
F
D
E
--
S
E
K
T
---
K
-
E
S
R
E
A
-
I
E
K
E
F
E
P
L
L
N
W
M
K
-
D
K
A
L
K
D
K
I
E
K
A
V
V
S
Q
R
L
T
E
S
P
C
A
L
V
A
S
Q
-
Y
G
W
S
--
G
N
M
E
R
I
M
K
A
Q
A
-------
Y
Q
TGKDISTNY
Y
A
S
---------
Q
K
--
K
T
F
E
I
N
P
R
H
P
L
I
K
D
M
L
R
R
V
K
E
D
E
-
D
D
K
T
V
S
D
L
A
V
V
L
F
E
T
A
T
L
R
S
G
Y
L
L
P
D
T
K
A
Y
G
D
R
I
E
R
M
L
R
L
S
L
N
-
122
Fugue
84.98
34%
-75
- C2 -
2O1U
3
?
A:
[34-661]
--------------------------------
M
M
K
L
I
I
N
S
L
Y
K
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
L
I
S
L
T
D
E
N
A
L
A
G
N
E
E
---
L
T
V
K
I
K
C
D
K
E
K
N
L
L
H
V
T
D
T
G
V
G
M
T
R
E
E
L
V
K
N
L
G
T
------------------------------
V
G
F
Y
S
A
F
L
V
A
D
K
V
I
V
T
S
K
H
N
-
N
D
--
T
--
Q
--
H
I
W
E
S
D
S
N
E
F
S
V
I
--
A
D
P
R
--
G
--
N
T
L
G
R
G
T
T
I
T
L
V
L
K
E
E
A
S
D
Y
L
E
L
D
T
I
K
N
L
V
K
K
Y
S
Q
F
I
N
F
P
I
Y
V
W
S
S
K
V
-
W
--------
D
W
-------
E
L
M
N
D
I
K
P
I
W
Q
R
P
S
K
E
V
E
D
D
E
Y
K
A
F
Y
K
S
F
S
K
E
S
D
D
P
M
A
Y
I
H
F
T
A
E
G
E
V
T
F
K
S
I
L
F
V
P
T
S
A
P
-
R
Y
-----------
I
K
L
Y
V
R
R
V
F
I
T
D
D
F
H
D
M
M
P
K
Y
L
N
F
V
K
G
V
V
D
S
D
D
L
P
L
N
V
S
R
E
T
L
Q
Q
H
K
L
L
K
V
I
R
K
K
L
V
R
K
T
L
D
M
I
K
K
I
A
D
E
K
Y
N
D
---
T
F
W
K
E
F
G
T
N
I
K
L
G
V
I
E
--
D
H
S
N
R
T
R
-
L
A
K
L
L
R
F
Q
S
S
H
---
H
P
S
D
-
I
T
S
L
D
Q
Y
V
E
R
M
K
E
K
Q
D
K
I
Y
F
M
A
G
S
S
R
K
E
A
E
S
S
P
F
V
E
R
L
L
K
K
G
Y
E
V
I
Y
L
T
E
P
V
D
E
Y
C
I
Q
A
L
P
E
F
D
G
K
R
F
Q
N
V
A
K
E
G
V
K
F
D
E
------
S
E
K
T
K
E
S
R
E
A
-
I
E
K
E
F
E
P
L
L
N
W
M
K
D
K
-
A
L
K
D
K
I
E
K
A
V
V
S
Q
R
L
T
E
S
P
C
A
L
V
A
S
Q
-
Y
G
W
S
--
G
N
M
E
R
I
M
K
A
Q
A
-------
Y
Q
---------
T
G
K
DISTNYYAS
Q
K
--
K
T
F
E
I
N
P
R
H
P
L
I
K
D
M
L
R
R
V
K
E
D
E
-
D
D
K
T
V
S
D
L
A
V
V
L
F
E
T
A
T
L
R
S
G
Y
L
L
P
D
T
K
A
Y
G
D
R
I
E
R
M
L
R
L
S
L
N
I
4
PsiBlast_PDB
84.83
35%
-77
- C2 -
2O1U
3
?
A:
[34-655]
--------------------------------
M
M
K
L
I
I
N
S
L
Y
K
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
L
I
S
L
T
D
E
N
A
L
A
G
N
E
E
---
L
T
V
K
I
K
C
D
K
E
K
N
L
L
H
V
T
D
T
G
V
G
M
T
R
E
E
L
V
K
N
L
G
T
------------------------------
V
G
F
Y
S
A
F
L
V
A
D
K
V
I
V
T
S
K
H
N
-
N
D
--
T
--
Q
-
H
-
I
W
E
S
D
S
N
-
E
F
S
V
I
A
D
-
P
R
--
G
--
N
T
L
G
R
G
T
T
I
T
L
V
L
K
E
E
A
S
D
Y
L
E
L
D
T
I
K
N
L
V
K
K
Y
S
Q
F
I
N
F
P
I
Y
V
W
-
S
S
K
------------V
W
D
W
---
E
L
M
N
D
I
K
P
I
W
Q
R
P
S
K
E
V
E
D
D
E
Y
K
A
F
Y
K
S
F
S
K
E
S
D
D
P
M
A
Y
I
H
F
T
A
E
G
E
V
T
F
K
S
I
L
F
V
P
T
S
A
P
R------------
Y
I
K
L
Y
V
R
R
V
F
I
T
D
D
F
H
D
M
M
P
K
Y
L
N
F
V
K
G
V
V
D
S
D
D
L
P
L
N
V
S
R
E
T
L
Q
Q
H
K
L
L
K
V
I
R
K
K
L
V
R
K
T
L
D
M
I
K
K
I
A
D
E
K
Y
N
D
---
T
F
W
K
E
F
G
T
N
I
K
L
G
V
I
E
D
H
S
N
R
T
R
---
L
A
K
L
L
R
F
Q
S
S
H
---
H
-
P
S
D
I
T
S
L
D
Q
Y
V
E
R
M
K
E
K
Q
D
K
I
Y
F
M
A
G
S
S
R
K
E
A
E
S
S
P
F
V
E
R
L
L
K
K
G
Y
E
V
I
Y
L
T
E
P
V
D
E
Y
C
I
Q
A
L
P
E
F
D
G
K
R
F
Q
N
V
A
K
E
G
V
---
K
F
D
E
S
E
K
T
K
E
S
R
---
E
A
-
I
E
K
E
F
E
P
L
L
N
W
M
K
D
K
-
A
L
K
D
K
I
E
K
A
V
V
S
Q
R
L
T
E
S
P
C
A
L
V
A
S
Q
-
Y
G
W
S
--
G
N
M
E
R
I
M
K
A
Q
A
Y
Q
TGKDI
S
T
---------
N
Y
Y
---------
A
S
QK
K
T
F
E
I
N
P
R
H
P
L
I
K
D
M
L
R
R
V
K
E
D
E
-
D
D
K
T
V
S
D
L
A
V
V
L
F
E
T
A
T
L
R
S
G
Y
L
L
P
D
T
K
A
Y
G
D
R
I
E
R
M
L
R
L
S
L
N
-
7
PsiBlast_PDB
84.72
31%
-83
- C4 -
4J0B
5
?
A:
[14-644]
-----
L
H
N
I
I
T
D
-
T
E
N
V
Q
G
S
F
S
K
H
E
F
Q
A
E
T
K
K
L
L
D
I
V
A
R
S
L
Y
S
E
K
E
V
F
I
R
E
L
I
S
N
G
S
D
A
L
E
K
L
R
H
------
R
M
I
T
A
G
G
D
T
A
P
M
E
I
H
L
Q
T
D
S
V
K
G
T
F
T
I
Q
D
T
G
V
G
M
N
K
E
D
L
V
S
N
L
G
T
I
A
R
S
G
S
K
A
F
L
D
A
L
Q
N
Q
A
E
A
S
S
S
I
--
I
G
Q
F
G
V
G
F
Y
S
A
F
M
V
A
D
K
V
E
V
Y
S
Q
S
A
E
A
D
--
A
--
P
-
G
Y
K
W
S
S
D
G
S
G
V
F
E
V
--
A
-
E
A
--
S
--
G
-
V
R
Q
G
T
K
I
V
L
H
L
K
D
D
C
K
E
F
S
S
E
D
R
V
K
E
V
V
T
K
Y
S
N
F
V
S
F
P
I
-
F
L
-
N
-------------
G
-------
R
R
L
N
T
L
Q
A
L
W
M
M
E
P
K
D
I
S
E
W
Q
H
E
E
F
Y
R
Y
V
A
Q
A
Y
D
K
P
R
Y
T
L
H
Y
R
A
D
A
P
L
N
I
R
S
I
F
Y
V
P
E
M
K
P
----------MG
S
S
V
A
L
Y
S
R
K
I
L
I
Q
T
K
A
T
D
I
L
P
K
W
L
R
F
L
R
G
V
V
D
S
E
D
I
P
L
N
L
S
R
E
L
L
Q
E
S
A
L
I
R
K
L
R
D
V
L
Q
Q
R
V
I
R
F
L
L
D
Q
S
K
K
D
P
E
K
Y
-
A
R
F
F
E
D
Y
G
L
F
M
R
E
G
I
V
T
T
G
E
Q
S
V
K
E
D
-
I
A
K
L
L
R
F
E
S
S
A
LP-
A
-
G
Q
-
Q
T
S
L
M
E
Y
S
S
R
M
K
A
G
T
R
N
I
Y
Y
L
C
A
P
N
R
H
L
A
E
H
S
P
Y
F
E
A
M
K
--
D
M
E
V
L
F
C
F
E
Q
F
D
E
L
T
L
L
H
L
R
E
F
D
R
K
K
L
I
S
A
-
E
T
---------------------
R
L
S
S
E
Q
A
E
D
L
L
A
W
M
R
-
N
-
A
L
V
Q
R
V
T
N
I
K
V
T
P
R
L
D
T
H
P
A
M
I
T
V
L
E
M
G
A
A
R
H
F
L
R
T
Q
--------------------------
Q
I
---------
L
Q
--
P
T
L
E
I
N
T
G
H
D
L
I
K
---
K
L
H
A
L
K
D
-
S
N
P
E
L
A
Q
L
L
L
E
Q
I
Y
D
N
A
M
I
A
A
G
L
N
E
D
P
R
P
M
I
S
R
L
N
Q
L
L
T
R
A
L
E
-
102
HHSearch
83.15
35%
-70
- C2 -
2CG9
1
HSP82_YEAST
A:
[2-676]
-----------
A
-
S
E
T
F
E
-------
F
Q
A
E
I
T
Q
L
M
S
L
I
I
N
T
V
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
K
S
L
S
D
P
K
Q
L
E
T
E
P
D
---
L
F
I
R
I
T
P
K
P
E
Q
K
V
L
E
I
R
D
S
G
I
G
M
T
K
A
E
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
S
A
G
----
A
D
V
S
M
I
G
Q
F
G
V
G
F
Y
S
L
F
L
V
A
D
R
V
Q
V
I
S
K
S
N
-
D
D
-----
E
-
Q
Y
I
W
E
S
N
A
G
G
S
F
T
V
--
T
-
L
D
--
E
VN
E
R
I
G
R
G
T
I
L
R
L
F
L
K
D
D
Q
L
E
Y
L
E
E
K
R
I
K
E
V
I
K
R
H
S
E
F
V
A
Y
P
I
Q
L
V
-
V
T
K
-
E
V
E
KEEEVQ
E
I
-------
E
E
L
N
K
T
K
P
L
W
T
R
N
P
S
D
I
T
Q
E
E
Y
N
A
F
Y
K
S
I
S
N
D
W
E
D
P
L
Y
V
K
H
F
S
V
E
G
Q
L
E
F
R
A
I
L
F
I
P
K
R
A
P
-
F
----------
N
N
I
K
L
Y
V
R
R
V
F
I
T
D
E
A
E
D
L
I
P
E
W
L
S
F
V
K
G
V
V
D
S
E
D
L
P
L
N
L
S
R
E
M
L
Q
Q
N
K
I
M
K
V
I
R
K
N
I
V
K
K
L
I
E
A
F
N
E
I
A
E
-
D
S
E
Q
F
-
E
K
F
Y
S
A
F
S
K
N
I
K
L
G
V
H
E
D
-
T
-
Q
N
R
A
A
-
L
A
K
L
L
R
Y
N
S
T
K
---
S
V
D
E
-
L
T
S
L
T
D
Y
V
T
R
M
P
E
H
Q
K
N
I
Y
Y
I
T
G
E
S
L
K
A
V
E
K
S
P
F
L
D
A
L
K
A
K
N
F
E
V
L
F
L
T
D
P
I
D
E
Y
A
F
T
Q
L
K
E
F
E
G
K
T
L
V
D
I
T
K
D
-
F
E
L
E
E
--
T
D
E
E
---
K
-
A
E
R
E
K
-
E
I
K
E
Y
E
P
L
T
K
A
L
K
-
E
-
I
L
G
D
Q
V
E
K
V
V
V
S
Y
K
L
L
D
A
P
A
A
I
R
T
G
Q
-
F
G
W
S
--
A
N
M
E
R
I
M
K
A
Q
A
----------------------------------
K
T
F
E
I
S
P
K
S
P
I
I
K
E
L
K
K
R
V
D
E
G
G
A
Q
D
K
T
V
K
D
L
T
K
L
L
Y
E
T
A
L
L
T
S
G
F
S
L
D
E
P
T
S
F
A
S
R
I
N
R
L
I
S
L
G
L
N
-
25
PsiBlast_CBE
81.33
31%
-74
- C4 -
4J0B
5
?
B:
[14-644]
-----
L
H
N
I
I
T
D
-
T
E
N
V
Q
G
S
F
S
K
H
E
F
Q
A
E
T
K
K
L
L
D
I
V
A
R
S
L
Y
S
E
K
E
V
F
I
R
E
L
I
S
N
G
S
D
A
L
E
K
L
R
H
------
R
M
I
T
A
G
--AP-
M
E
I
H
L
Q
T
D
S
V
K
G
T
F
T
I
Q
D
T
G
V
G
M
N
K
E
D
L
V
S
N
L
G
T
I
A
R
S
G
S
K
A
F
L
D
A
L
Q
-----
S
S
S
I
--
I
G
Q
F
G
V
G
F
Y
S
A
F
M
V
A
D
K
V
E
V
Y
S
Q
S
A
E
A
D
--
A
--
P
-
G
Y
K
W
S
S
D
G
S
G
V
F
E
V
--
A
-
E
A
--
S
--
G
-
V
R
Q
G
T
K
I
V
L
H
L
K
D
D
C
K
E
F
S
S
E
D
R
V
K
E
V
V
T
K
Y
S
N
F
V
S
F
P
I
-
F
L
-
N
-------------
G
-------
R
R
L
N
T
L
Q
A
L
W
M
M
E
P
K
D
I
S
E
W
Q
H
E
E
F
Y
R
Y
V
A
Q
A
Y
D
K
P
R
Y
T
L
H
Y
R
A
D
A
P
L
N
I
R
S
I
F
Y
V
P
E
M
K
P
--
S
M
F
D
V
S
R
E
M--
S
V
A
L
Y
S
R
K
I
L
I
Q
T
K
--
D
I
L
P
K
W
L
R
F
L
R
G
V
V
D
S
E
D
I
P
L
N
L
S
R
E
L
L
Q
E
S
A
L
I
R
K
L
R
D
V
L
Q
Q
R
V
I
R
F
L
L
D
Q
S
K
K
D
P
E
K
Y
-
A
R
F
F
E
D
Y
G
L
F
M
R
E
G
I
V
T
T
G
E
Q
S
V
K
E
D
-
I
A
K
L
L
R
F
E
S
S
A
LP-
A
-
G
Q
-
Q
T
S
L
M
E
Y
S
S
R
M
K
A
G
T
R
N
I
Y
Y
L
C
A
P
N
R
H
L
A
E
H
S
P
Y
F
E
A
M
K
Q
K
D
M
E
V
L
F
C
F
E
Q
F
D
E
L
T
L
L
H
L
R
E
F
D
R
K
K
L
I
S
A
-
E
T
D
I
V
V
D
H
Y
K
-
E
E
K
F
Q
D
S
K
P
A
S
E
R
L
S
S
E
Q
A
E
D
L
L
A
W
M
R
-
N
-
A
L
V
Q
R
V
T
N
I
K
V
T
P
R
L
D
T
H
P
A
M
I
T
V
L
E
M
G
A
A
R
H
F
L
R
T
----------------------------
I
---------
L
Q
--
P
T
L
E
I
N
T
G
H
D
L
I
K
---
K
L
H
A
L
K
D
-
S
N
P
E
L
A
Q
L
L
L
E
Q
I
Y
D
N
A
M
I
A
A
G
L
N
E
D
P
R
P
M
I
S
R
L
N
Q
L
L
T
R
A
L
E
-
8
PsiBlast_PDB
77.10
36%
-89
- C4 -
4Z1F
1
TRAP1_HUMAN
A:
[21-491]
-------
S
V
-
Q
G
S
T
S
K
H
E
-------
F
Q
A
E
T
K
K
L
L
D
I
V
A
R
S
L
Y
S
E
K
E
V
F
I
R
E
L
I
S
N
A
S
D
A
L
E
K
L
R
H
K
L
V
S
D
G
Q
A
L
P
---
E
---
M
E
I
H
L
Q
T
N
A
E
K
G
T
I
T
I
Q
D
T
G
I
G
M
T
Q
E
E
L
V
S
N
--------------------------------
G
V
G
F
Y
S
A
F
M
V
A
D
R
V
E
V
Y
S
R
S
A
-
A
P
--
G
--
S
L
G
Y
Q
W
L
S
D
G
S
G
V
F
E
I
--
A
-
E
A
--
S
--
G
-
V
R
T
G
T
K
I
I
I
H
L
K
S
D
C
K
E
F
S
S
E
A
R
V
R
D
V
V
T
K
Y
S
N
F
V
S
F
P
L
Y
L
---------------
N
G
-------
R
R
M
N
T
L
Q
A
I
W
M
M
D
P
K
D
V
R
E
W
Q
H
E
E
F
Y
R
Y
V
A
Q
A
H
D
K
P
R
Y
T
L
H
Y
K
T
D
A
P
L
N
I
R
S
I
F
Y
V
P
D
M
K
P
-------------
S
V
A
L
Y
S
R
K
V
L
I
Q
T
K
A
T
D
I
L
P
K
W
L
R
F
I
R
G
V
V
D
S
E
D
I
P
----------
S
A
L
I
R
K
L
R
D
V
L
Q
Q
R
L
I
K
F
F
I
D
Q
S
K
K
D
A
E
K
Y
-
A
K
F
F
E
D
Y
G
L
F
M
R
E
G
I
V
T
A
T
E
Q
E
V
K
E
D
-
I
A
K
L
L
R
Y
E
S
S
A
LP-
S
-
G
Q
-
L
T
S
L
S
E
Y
A
S
R
M
R
A
G
-
R
N
I
Y
Y
L
C
A
P
N
R
H
L
A
E
H
S
P
Y
Y
E
A
M
K
K
K
D
T
E
V
L
F
C
F
E
Q
F
D
E
L
T
L
L
H
L
R
E
F
D
K
K
K
L
I
S
V
E
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
76.69
36%
-84
- C4 -
4Z1H
1
TRAP1_HUMAN
A:
[21-491]
-------
S
V
-
Q
G
S
T
S
K
H
E
-------
F
Q
A
E
T
K
K
L
L
D
I
V
A
R
S
L
Y
S
E
K
E
V
F
I
R
E
L
I
S
N
A
S
D
A
L
E
K
L
R
H
K
L
V
S
D
G
Q
A
L
P
---
E
---
M
E
I
H
L
Q
T
N
A
E
K
G
T
I
T
I
Q
D
T
G
I
G
M
T
Q
E
E
L
V
S
N
-------------------------------
F
G
V
G
F
Y
S
A
F
M
V
A
D
R
V
E
V
Y
S
R
S
A
-
A
P
--
G
--
S
L
G
Y
Q
W
L
S
D
G
S
G
V
F
E
I
--
A
-
E
A
--
S
--
G
-
V
R
T
G
T
K
I
I
I
H
L
K
S
D
C
K
E
F
S
S
E
A
R
V
R
D
V
V
T
K
Y
S
N
F
V
S
F
P
L
Y
L
---------------
N
G
-------
R
R
M
N
T
L
Q
A
I
W
M
M
D
P
K
D
V
R
E
W
Q
H
E
E
F
Y
R
Y
V
A
Q
A
H
D
K
P
R
Y
T
L
H
Y
K
T
D
A
P
L
N
I
R
S
I
F
Y
V
P
D
M
K
P
-------------
S
V
A
L
Y
S
R
K
V
L
I
Q
T
K
A
T
D
I
L
P
K
W
L
R
F
I
R
G
V
V
D
S
E
D
I
P
----------
S
A
L
I
R
K
L
R
D
V
L
Q
Q
R
L
I
K
F
F
I
D
Q
S
K
K
D
A
E
K
Y
-
A
K
F
F
E
D
Y
G
L
F
M
R
E
G
I
V
T
A
T
E
Q
E
V
K
E
D
-
I
A
K
L
L
R
Y
E
S
S
A
LP-
S
-
G
Q
-
L
T
S
L
S
E
Y
A
S
R
M
R
A
G
-
R
N
I
Y
Y
L
C
A
P
N
R
H
L
A
E
H
S
P
Y
Y
E
A
M
K
K
K
D
T
E
V
L
F
C
F
E
Q
F
D
E
L
T
L
L
H
L
R
E
F
D
K
K
K
L
I
S
V
E
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
76.61
43%
-77
- C2 -
1Y4U
-
HTPG_ECOLI
A:
[1-489]
--------
M
-
K
G
-
Q
E
T
R
G
-------
F
Q
S
E
V
K
Q
L
L
H
L
M
I
H
S
L
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
A
D
K
L
R
F
R
A
L
S
N
P
D
L
Y
E
G
D
G
E
---
L
R
V
R
V
S
F
D
K
D
K
R
T
L
T
I
S
D
N
G
V
G
M
T
R
D
E
V
I
D
H
L
G
T
I
A
K
S
G
T
-------------------
I
G
Q
F
G
V
G
F
Y
S
A
F
I
V
A
D
K
V
T
V
R
T
R
A
A
-
G
E
KP
E
--
N
-
G
V
F
W
E
S
A
G
E
G
E
Y
T
V
--
A
-
D
I
--
T
--
K
E
-
D
R
G
T
E
I
T
L
H
L
R
E
G
E
D
E
F
L
D
D
W
R
V
R
S
I
I
S
K
Y
S
D
H
I
A
L
P
V
E
I
E
-
K
R
E
-
E
--------
K
D
G
E
T
V
I
S
W
E
K
I
N
K
A
Q
A
L
W
T
R
N
K
S
E
I
T
D
E
E
Y
K
E
F
Y
K
H
I
A
H
D
F
N
D
P
L
T
W
S
H
N
R
V
E
G
K
Q
E
Y
T
S
L
L
Y
I
P
S
Q
A
P
-
W
D
M
W
N
R
D
H
K
--
H
G
L
K
L
Y
V
Q
R
V
F
I
M
D
D
A
E
Q
F
M
P
N
Y
L
R
F
V
R
G
L
I
D
S
S
D
L
P
L
N
V
S
R
E
I
L
Q
D
S
T
V
T
R
N
L
R
N
A
L
T
K
R
V
L
Q
M
L
E
K
L
A
K
D
D
A
E
K
Y
-
Q
T
F
W
Q
Q
F
G
L
V
L
K
E
G
P
A
E
D
F
A
N
Q
E
A
I
A
K
L
L
R
F
A
S
T
H
T
D
S
---
S
-
A
Q
-
T
V
S
L
E
D
Y
V
S
R
M
K
E
G
Q
E
K
I
Y
Y
I
T
A
D
S
Y
A
A
A
K
S
S
P
H
L
E
L
L
R
K
K
G
I
E
V
L
L
L
S
D
R
I
D
E
W
M
M
N
Y
L
T
E
F
D
G
K
P
F
Q
S
V
S
K
V
D
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
76.38
36%
-85
- C4 -
4Z1I
2
TRAP1_HUMAN
B:
[21-491]
-------
S
V
-
Q
G
S
T
S
K
H
E
-------
F
Q
A
E
T
K
K
L
L
D
I
V
A
R
S
L
Y
S
E
K
E
V
F
I
R
E
L
I
S
N
A
S
D
A
L
E
K
L
R
H
K
L
V
S
D
G
Q
A
L
P
---
E
---
M
E
I
H
L
Q
T
N
A
E
K
G
T
I
T
I
Q
D
T
G
I
G
M
T
Q
E
E
L
V
S
N
L
G
T
I
A
R
S
G
S
K
A
F
L
D
A
----
A
E
A
S
S
--
K
I
I
G
Q
F
G
V
G
F
Y
S
A
F
M
V
A
D
R
V
E
V
Y
S
R
S
A
-
A
P
--
G
--
S
L
G
Y
Q
W
L
S
D
G
S
G
V
F
E
I
--
A
-
E
A
--
S
--
G
-
V
R
T
G
T
K
I
I
I
H
L
K
S
D
C
K
E
F
S
S
E
A
R
V
R
D
V
V
T
K
Y
S
N
F
V
S
F
P
L
Y
L
---------------
N
G
-------
R
R
M
N
T
L
Q
A
I
W
M
M
D
P
K
D
V
R
E
W
Q
H
E
E
F
Y
R
Y
V
A
Q
A
H
D
K
P
R
Y
T
L
H
Y
K
T
D
A
P
L
N
I
R
S
I
F
Y
V
P
D
M
K
P
--
S
M
F
--------
S
V
A
L
Y
S
R
K
V
L
I
Q
T
K
A
T
D
I
L
P
K
W
L
R
F
I
R
G
V
V
D
S
E
D
I
P
L
N
L
S
R
E
L
L
Q
E
S
A
L
I
R
K
L
R
D
V
L
Q
Q
R
L
I
K
F
F
I
D
Q
S
K
K
D
A
E
K
Y
-
A
K
F
F
E
D
Y
G
L
F
M
R
E
G
I
V
T
A
T
E
Q
E
V
K
E
D
-
I
A
K
L
L
R
Y
E
S
S
A
LP-
S
-
G
Q
-
L
T
S
L
S
E
Y
A
S
R
M
R
A
G
T
R
N
I
Y
Y
L
C
A
P
N
R
H
L
A
E
H
S
P
Y
Y
E
A
M
K
K
K
D
T
E
V
L
F
C
F
E
Q
F
D
E
L
T
L
L
H
L
R
E
F
D
K
K
K
L
I
S
V
E
T
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
76.07
36%
-87
- C4 -
4Z1G
1
TRAP1_HUMAN
A:
[21-491]
-------
S
V
-
Q
G
S
T
S
K
H
E
-------
F
Q
A
E
T
K
K
L
L
D
I
V
A
R
S
L
Y
S
E
K
E
V
F
I
R
E
L
I
S
N
A
S
D
A
L
E
K
L
R
H
K
L
V
S
D
G
Q
A
L
P
---
E
---
M
E
I
H
L
Q
T
N
A
E
K
G
T
I
T
I
Q
D
T
G
I
G
M
T
Q
E
E
L
V
S
---------------------------------
G
V
G
F
Y
S
A
F
M
V
A
D
R
V
E
V
Y
S
R
S
A
-
A
P
--
G
--
S
L
G
Y
Q
W
L
S
D
G
S
G
V
F
E
I
--
A
-
E
A
--
S
--
G
-
V
R
T
G
T
K
I
I
I
H
L
K
S
D
C
K
E
F
S
S
E
A
R
V
R
D
V
V
T
K
Y
S
N
F
V
S
F
P
L
Y
L
---------------
N
G
-------
R
R
M
N
T
L
Q
A
I
W
M
M
D
P
K
D
V
R
E
W
Q
H
E
E
F
Y
R
Y
V
A
Q
A
H
D
K
P
R
Y
T
L
H
Y
K
T
D
A
P
L
N
I
R
S
I
F
Y
V
P
D
M
K
P
-------------
S
V
A
L
Y
S
R
K
V
L
I
Q
T
K
A
T
D
I
L
P
K
W
L
R
F
I
R
G
V
V
D
S
E
D
I
P
----------
S
A
L
I
R
K
L
R
D
V
L
Q
Q
R
L
I
K
F
F
I
D
Q
S
K
K
D
A
E
K
Y
-
A
K
F
F
E
D
Y
G
L
F
M
R
E
G
I
V
T
A
T
E
Q
E
V
K
E
D
-
I
A
K
L
L
R
Y
E
S
S
A
LP-
S
-
G
Q
-
L
T
S
L
S
E
Y
A
S
R
M
R
A
--
R
N
I
Y
Y
L
C
A
P
N
R
H
L
A
E
H
S
P
Y
Y
E
A
M
K
K
K
D
T
E
V
L
F
C
F
E
Q
F
D
E
L
T
L
L
H
L
R
E
F
D
K
K
K
L
I
S
V
E
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
75.96
43%
-80
- C2 -
1Y4S
2
HTPG_ECOLI
B:
[1-483]
--------
M
-
K
G
-
Q
E
T
R
G
-------
F
Q
S
E
V
K
Q
L
L
H
L
M
I
H
S
L
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
A
D
K
L
R
F
R
A
L
S
N
P
D
L
Y
E
G
D
G
E
---
L
R
V
R
V
S
F
D
K
D
K
R
T
L
T
I
S
D
N
G
V
G
M
T
R
D
E
V
I
D
H
L
G
T
I
A
K
S
G
T
K
S
F
L
E
S
----------
S
Q
L
I
G
Q
F
G
V
G
F
Y
S
A
F
I
V
A
D
K
V
T
V
R
T
R
A
A
-
G
E
KP
E
--
N
-
G
V
F
W
E
S
A
G
E
G
E
Y
T
V
--
A
-
D
I
--
T
--
K
E
-
D
R
G
T
E
I
T
L
H
L
R
E
G
E
D
E
F
L
D
D
W
R
V
R
S
I
I
S
K
Y
S
D
H
I
A
L
P
V
E
I
E
-
K
R
E
-
E
--------
K
D
GETVISW
E
K
I
N
K
A
Q
A
L
W
T
R
N
K
S
E
I
T
D
E
E
Y
K
E
F
Y
K
H
I
A
H
D
F
N
D
P
L
T
W
S
H
N
R
V
E
G
K
Q
E
Y
T
S
L
L
Y
I
P
S
Q
A
P
-
W
D
M
W
N
R
D
H
K
--
H
G
L
K
L
Y
V
Q
R
V
F
I
M
D
D
A
E
Q
F
M
P
N
Y
L
R
F
V
R
G
L
I
D
S
S
D
L
P
L
N
V
S
R
E
I
L
Q
D
S
T
V
T
R
N
L
R
N
A
L
T
K
R
V
L
Q
M
L
E
K
L
A
K
D
D
A
E
K
Y
-
Q
T
F
W
Q
Q
F
G
L
V
L
K
E
G
P
A
E
D
F
A
N
Q
E
A
I
A
K
L
L
R
F
A
S
T
H
T
D
S
---
S
-
A
Q
-
T
V
S
L
E
D
Y
V
S
R
M
K
E
G
Q
E
K
I
Y
Y
I
T
A
D
S
Y
A
A
A
K
S
S
P
H
L
E
L
L
R
K
K
G
I
E
V
L
L
L
S
D
R
I
D
E
W
M
M
N
Y
L
T
E
F
D
G
K
P
F
Q
S
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
75.50
38%
-77
- C2 -
2O1W
-
?
A:
[95-593]
------------------------------------------
K
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
L
I
S
L
T
D
E
N
A
L
A
G
N
E
E
---
L
T
V
K
I
K
C
D
K
E
K
N
L
L
H
V
T
D
T
G
V
G
M
T
R
E
E
L
V
K
N
L
G
T
------------------------------
V
G
F
Y
S
A
F
L
V
A
D
K
V
I
V
T
S
K
H
N
-
N
D
--
T
--
Q
-
H
-
I
W
E
S
D
S
N
-
E
F
S
V
I
A
D
-
P
R
--
G
--
N
T
L
G
R
G
T
T
I
T
L
V
L
K
E
E
A
S
D
Y
L
E
L
D
T
I
K
N
L
V
K
K
Y
S
Q
F
I
N
F
P
I
Y
V
W
-
S
S
K
T---------
K
T
V
W
D
W
---
E
L
M
N
D
I
K
P
I
W
Q
R
P
S
K
E
V
E
D
D
E
Y
K
A
F
Y
K
S
F
S
K
E
S
D
D
P
M
A
Y
I
H
F
T
A
E
G
E
V
T
F
K
S
I
L
F
V
P
T
S
A
P
R------------
Y
I
K
L
Y
V
R
R
V
F
I
T
D
D
F
H
D
M
M
P
K
Y
L
N
F
V
K
G
V
V
D
S
D
D
L
P
L
N
V
S
R
E
T
L
Q
Q
H
K
L
L
K
V
I
R
K
K
L
V
R
K
T
L
D
M
I
K
K
I
A
D
E
K
Y
N
D
---
T
F
W
K
E
F
G
T
N
I
K
L
G
V
I
E
D
H
S
N
R
T
R
---
L
A
K
L
L
R
F
Q
S
S
H
---
H
-
P
S
D
I
T
S
L
D
Q
Y
V
E
R
M
K
E
K
Q
D
K
I
Y
F
M
A
G
S
S
R
K
E
A
E
S
S
P
F
V
E
R
L
L
K
K
G
Y
E
V
I
Y
L
T
E
P
V
D
E
Y
C
I
Q
A
L
P
E
F
D
G
K
R
F
Q
N
V
A
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
HHSearch
74.09
44%
-77
- C2 -
1Y4S
2
HTPG_ECOLI
A:
[3-483]
-----------
G
-
Q
E
T
R
G
-------
F
Q
S
E
V
K
Q
L
L
H
L
M
I
H
S
L
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
A
D
K
L
R
F
R
A
L
S
N
P
D
L
Y
E
G
D
G
E
---
L
R
V
R
V
S
F
D
K
D
K
R
T
L
T
I
S
D
N
G
V
G
M
T
R
D
E
V
I
D
H
L
G
T
I
A
K
S
G
T
K
S
F
L
E
S
----------
S
Q
L
I
G
Q
F
G
V
G
F
Y
S
A
F
I
V
A
D
K
V
T
V
R
T
R
A
A
-
G
E
--
K
PE
N
-
G
V
F
W
E
S
A
G
E
G
E
Y
T
V
--
A
-
D
I
--
T
---
K
E
D
R
G
T
E
I
T
L
H
L
R
E
G
E
D
E
F
L
D
D
W
R
V
R
S
I
I
S
K
Y
S
D
H
I
A
L
P
V
E
I
E
-
K
R
E
-
E
KDG
E
T
V
I
-
S
W
-------
E
K
I
N
K
A
Q
A
L
W
T
R
N
K
S
E
I
T
D
E
E
Y
K
E
F
Y
K
H
I
A
H
D
F
N
D
P
L
T
W
S
H
N
R
V
E
G
K
Q
E
Y
T
S
L
L
Y
I
P
S
Q
A
P
-
W
D
M
W
N
R
D
H
K
--
H
G
L
K
L
Y
V
Q
R
V
F
I
M
D
D
A
E
Q
F
M
P
N
Y
L
R
F
V
R
G
L
I
D
S
S
D
L
P
L
N
V
S
R
E
I
L
Q
D
S
T
V
T
R
N
L
R
N
A
L
T
K
R
V
L
Q
M
L
E
K
L
A
K
D
D
A
E
K
Y
-
Q
T
F
W
Q
Q
F
G
L
V
L
K
E
G
P
A
E
D
F
--
A
N
Q
E
A
-
I
A
K
L
L
R
F
A
S
T
H
TDS
S
-
A
Q
-
T
V
S
L
E
D
Y
V
S
R
M
K
E
G
Q
E
K
I
Y
Y
I
T
A
D
S
Y
A
A
A
K
S
S
P
H
L
E
L
L
R
K
K
G
I
E
V
L
L
L
S
D
R
I
D
E
W
M
M
N
Y
L
T
E
F
D
G
K
P
F
Q
S
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
73.94
43%
-77
- C2 -
1Y4S
2
HTPG_ECOLI
A:
[1-483]
--------
M
-
K
G
-
Q
E
T
R
G
-------
F
Q
S
E
V
K
Q
L
L
H
L
M
I
H
S
L
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
A
D
K
L
R
F
R
A
L
S
N
P
D
L
Y
E
G
D
G
E
---
L
R
V
R
V
S
F
D
K
D
K
R
T
L
T
I
S
D
N
G
V
G
M
T
R
D
E
V
I
D
H
L
G
T
I
A
K
S
G
T
K
S
F
L
E
S
----------
S
Q
L
I
G
Q
F
G
V
G
F
Y
S
A
F
I
V
A
D
K
V
T
V
R
T
R
A
A
-
G
E
KP
E
--
N
-
G
V
F
W
E
S
A
G
E
G
E
Y
T
V
--
A
-
D
I
--
T
--
K
E
-
D
R
G
T
E
I
T
L
H
L
R
E
G
E
D
E
F
L
D
D
W
R
V
R
S
I
I
S
K
Y
S
D
H
I
A
L
P
V
E
I
E
-
K
R
E
-
E
--------
K
D
G
E
T
V
I
S
W
E
K
I
N
K
A
Q
A
L
W
T
R
N
K
S
E
I
T
D
E
E
Y
K
E
F
Y
K
H
I
A
H
D
F
N
D
P
L
T
W
S
H
N
R
V
E
G
K
Q
E
Y
T
S
L
L
Y
I
P
S
Q
A
P
-
W
D
M
W
N
R
D
H
K
--
H
G
L
K
L
Y
V
Q
R
V
F
I
M
D
D
A
E
Q
F
M
P
N
Y
L
R
F
V
R
G
L
I
D
S
S
D
L
P
L
N
V
S
R
E
I
L
Q
D
S
T
V
T
R
N
L
R
N
A
L
T
K
R
V
L
Q
M
L
E
K
L
A
K
D
D
A
E
K
Y
-
Q
T
F
W
Q
Q
F
G
L
V
L
K
E
G
P
A
E
D
F
A
N
Q
E
A
I
A
K
L
L
R
F
A
S
T
H
T
D
S
---
S
-
A
Q
-
T
V
S
L
E
D
Y
V
S
R
M
K
E
G
Q
E
K
I
Y
Y
I
T
A
D
S
Y
A
A
A
K
S
S
P
H
L
E
L
L
R
K
K
G
I
E
V
L
L
L
S
D
R
I
D
E
W
M
M
N
Y
L
T
E
F
D
G
K
P
F
Q
S
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------