@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0150: (2015-11-28 )
MKKFLEGLLIWLVIIVLISVAYIQFSGNIGKSKTTIPFSEFLTKLEDNDIENIVIKNQSIEGKFRDGSNFNSSGIIYSDLIKGLHDKKVKFSFSTGDSAMSIIGRLLIQWIPTFIFIGLLLFLLKQTQTGGNRTISFGKSKARLMTSGKKVTFDDVAGIDEAKEELVEIVDFLKQRQKFQVLGGKIPKGCLLIGSPGTGKTLLARAIAGEANVPFFSISGSDFVEMFVGVGASRVRDMFDQGKKNAPCIIFIDEIDAVGRHRGIGLGGGNDEREQTLNQLLVEMDGFESNEGVIIVAATNRPDVLDPALLRPGRFDRQITISLPDINGRERILNTHIKKISIAPDVNVKTVARGTPGFSGADLANLVNESALIAARRNKKIVTMDDFEYARDKVMMGVERRSLMMTEEEKKLTAYHEAGHAIVAVNMSASDPIHKATIIPRGRALGLVMRLPETDRVSHTREKMIADITVAMGGRVAEELIFGYDKITSGASSDIKQASDLSRAMVTKWGMSDKIGPVYHNREQNVHSSDIISEDTLKLIDEEVKRVVSSCYEKAKDILTKRCKDLELIAENLLEFETLTGDEIKDILSGKKIVRNDNESKEKVRKSSL
Atome Classification :
(39 SA)
---------------------.........10.......-----.20........30........40...-.....50......-------..60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170-..-.....180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......-290.......300.......310.......320.......330......--.340.--......350.......360.......370.....-----------------..380.......390.......400.......410.......420.......430.......440-.......450.......460.......470.......480.......490.......500.......510......-.520.....----..530-.-----.......540.......550.......560.......570.......580.......590.......600.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------
M
K
K
F
L
E
G
L
L
I
W
L
V
I
I
V
L
I
-----
S
V
A
Y
I
Q
F
SGNIGKSKTTI
P
F
S
E
F
L
T
K
-LEDNDI
E
N
I
V
I
KN-------QSI
E
G
K
FRDGSNFNSSGI
I
Y
S
D
L
I
K
G
LHDK
K
V
K
F
S
FSTG
D
S
A
M
S
I
I
G
R
L
L
I
Q
W
I
P
T
F
I
F
I
G
L
L
L
F
L
L
K
QTQTGGN
R
T
I
SFGKSK
A
R
L
MTSG
K
K
V
T
F
D
DVAG
I
D
E
A
K
E
E
L
V
E
I
V
D
F
-
L
K
-
Q
R
Q
K
F
Q
V
LGGKIPK
G
C
L
L
IGSPGT
G
K
T
L
L
A
R
A
IAGEANV
P
F
F
SIS
G
S
D
F
V
E
M
F
V
GV
G
A
S
R
V
R
D
M
F
DQGKKNA
P
C
I
I
F
I
DEIDAVGRHRGIGLGGG
N
D
E
R
E
Q
T
L
N
Q
L
L
V
EMDGFES-NE
G
V
I
I
V
A
ATNRPDVL
D
P
A
LLRPGRFD
R
Q
I
T
I
SLPDIN
G
R
E
R
I
L
N
T
H
I
K
--
K
I
SIA--PDV
N
V
K
T
V
ARGTPGFS
G
A
D
L
A
N
L
V
N
E
S
A
L
I
A
ARR-----------------N
K
K
I
V
T
M
D
D
F
E
Y
A
R
D
K
V
M
M
G
V
E
R
R
S
L
MM
T
E
E
E
K
K
L
T
A
Y
HEAG
H
A
I
V
A
V
NMSASDPI
H
K
A
T
IIPRG-
R
A
L
G
L
V
M
RLPETD
R
V
S
H
T
R
E
K
M
I
A
D
I
T
VAM
G
G
R
V
A
E
E
L
I
F
G
Y
D
KITSGAS
S
D
I
K
Q
A
S
D
L
S
R
A
M
V
T
KWGMSDKIGPV-YHNREQNVH----SSDI--I-----
S
E
D
T
L
K
L
I
D
E
E
V
K
R
V
V
S
S
C
Y
E
K
A
K
D
I
L
T
K
R
C
K
D
L
E
L
I
A
E
N
L
L
E
FETL
T
G
D
E
I
K
D
I
LSG
K
K
IVRNDN
E
S
K
E
K
V
RKSSL
24
PsiBlast_CBE
95.11
56%
-95
- C1 -
2CE7
11
FTSH_THEMA
F:
[8-457]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
N
K
R
V
T
F
K
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
-
L
K
-
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
I
L
L
V
G
P
P
G
T
G
K
T
L
L
A
R
A
V
A
G
E
A
N
V
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
----------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
S
-
K
E
G
I
I
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
--
N
K
P
L
A
--
E
D
V
N
L
E
I
I
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
-----------------
G
R
D
K
I
T
M
K
D
F
E
E
A
I
D
R
V
I
---------
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
I
P
R
G
Y
K
A
L
G
----------
Y
L
V
S
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
F
G
--
D
V
T
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
C
Q
L
G
M
S
E
E
L
G
P
L
A
W
G
------------------RNY--
S
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
L
S
E
E
F
-----------------
22
PsiBlast_CBE
93.96
56%
-97
- C1 -
2CEA
1
FTSH_THEMA
D:
[8-457]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
N
K
R
V
T
F
K
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
-
L
K
-
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
I
L
L
V
G
P
P
G
T
G
K
T
L
L
A
R
A
V
A
G
E
A
N
V
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
------------
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
S
-
K
E
G
I
I
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
--
N
K
P
L
A
--
E
D
V
N
L
E
I
I
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
-----------------
G
R
D
K
I
T
M
K
D
F
E
E
A
I
D
R
V
I
A
----
K
S
L
L
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
I
P
R
G
Y--------------
Y
L
V
S
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
F
G
--
D
V
T
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
C
Q
L
G
M
S
E
E
L
G
P
L
A
W
G
------------------LRNY-
S
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
L
S
E
E
F
E
----------------
25
PsiBlast_CBE
93.95
56%
-97
- C1 -
2CE7
1
FTSH_THEMA
D:
[8-457]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
N
K
R
V
T
F
K
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
-
L
K
-
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
I
L
L
V
G
P
P
G
T
G
K
T
L
L
A
R
A
V
A
G
E
A
N
V
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
------------
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
S
-
K
E
G
I
I
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
--
N
K
P
L
A
--
E
D
V
N
L
E
I
I
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
-----------------
G
R
D
K
I
T
M
K
D
F
E
E
A
I
D
R
V
I
A
----
K
S
L
L
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
I
P
R
G
Y--------------
Y
L
V
S
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
F
G
--
D
V
T
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
C
Q
L
G
M
S
E
E
L
G
P
L
A
W
G
------------------LRNY-
S
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
L
S
E
E
F
E
----------------
23
PsiBlast_CBE
93.82
56%
-97
- C1 -
2CEA
2
FTSH_THEMA
C:
[8-457]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
N
K
R
V
T
F
K
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
-
L
K
-
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
I
L
L
V
G
P
P
G
T
G
K
T
L
L
A
R
A
V
A
G
E
A
N
V
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
-------------
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
S
-
K
E
G
I
I
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
--
N
K
P
L
A
--
E
D
V
N
L
E
I
I
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
-----------------
G
R
D
K
I
T
M
K
D
F
E
E
A
I
D
R
V
I
--------
L
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
I
P
R
G
Y
K
A
L
G
Y
T
L
H
L
P
E
E
D
K
Y
L
V
S
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
F
G
--
D
V
T
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
C
Q
L
G
M
S
E
E
L
G
P
L
A
W
G
------------------RNY--
S
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
L
S
E
E
F
E
----------------
26
PsiBlast_CBE
93.74
56%
-96
- C1 -
2CE7
2
FTSH_THEMA
C:
[8-457]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
N
K
R
V
T
F
K
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
-
L
K
-
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
I
L
L
V
G
P
P
G
T
G
K
T
L
L
A
R
A
V
A
G
E
A
N
V
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
-------------
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
S
-
K
E
G
I
I
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
--
N
K
P
L
A
--
E
D
V
N
L
E
I
I
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
-----------------
G
R
D
K
I
T
M
K
D
F
E
E
A
I
D
R
V
I
--------
L
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
I
P
R
G
Y
K
A
L
G
Y
T
L
H
L
P
E
E
D
K
Y
L
V
S
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
F
G
--
D
V
T
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
C
Q
L
G
M
S
E
E
L
G
P
L
A
W
G
------------------RNY--
S
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
L
S
E
E
F
E
----------------
21
PsiBlast_CBE
93.51
56%
-96
- C1 -
2CEA
11
FTSH_THEMA
F:
[8-457]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
N
K
R
V
T
F
K
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
-
L
K
-
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
I
L
L
V
G
P
P
G
T
G
K
T
L
L
A
R
A
V
A
G
E
A
N
V
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
----------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
S
-
K
E
G
I
I
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
--
N
K
P
L
A
--
E
D
V
N
L
E
I
I
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
-----------------
G
R
D
K
I
T
M
K
D
F
E
E
A
I
D
R
V
I
---------
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
I
P
R
G
Y
K
A
L
G
----------
Y
L
V
S
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
F
G
--
D
V
T
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
C
Q
L
G
M
S
E
E
L
G
P
L
A
W
G
------------------RNY--
S
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
L
S
E
E
F
-----------------
126
Fugue
93.32
57%
-90
- C1 -
2CE7
1
FTSH_THEMA
A:
[5-457]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
P
S
G
N
K
R
V
T
F
K
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
-
L
K
-
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
I
L
L
V
G
P
P
G
T
G
K
T
L
L
A
R
A
V
A
G
E
A
N
V
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
H
---------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
S
-
K
E
G
I
I
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
--
N
K
P
L
A
--
E
D
V
N
L
E
I
I
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
-----------------
G
R
D
K
I
T
M
K
D
F
E
E
A
I
D
R
V
I
L
--------
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
I
K
Y
L
-----------------
V
S
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
F
G
--
D
V
T
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
C
Q
L
G
M
S
E
E
L
G
P
L
-
A
W
G
K
L
R
N
------------
Y
-----
S
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
L
S
E
-------------------
1
PsiBlast_PDB
93.21
56%
-92
- C1 -
3KDS
2
FTSH_THEMA
E:
[11-457]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
V
T
F
K
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
-
L
K
-
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
I
L
L
V
G
P
P
G
T
G
A
T
L
L
A
R
A
V
A
G
E
A
N
V
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
H
---------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
S
-
K
E
G
I
I
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
--
N
K
P
L
A
--
E
D
V
N
L
E
I
I
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
-----------------
G
R
D
K
I
T
M
K
D
F
E
E
A
I
D
R
V
I
A
G
P
A
R
K
S
L
L
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
I
P
R
G
Y
K
A
L
G
Y
T
L
H
L
P
E
E
D
K
Y
L
V
S
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
F
G
--
D
V
T
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
C
Q
L
G
M
S
E
E
L
G
P
L
A
W
G
K
-----------------RLRNY
S
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
L
S
E
-------------------
37
PsiBlast_CBE
90.22
54%
-89
- C1 -
4Z8X
3
FTSH_AQUAE
C:
[14-469]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
F
K
D
V
A
G
I
E
E
V
K
E
E
V
K
E
I
I
E
Y
-
L
K
-
D
P
V
K
F
Q
K
L
G
G
R
P
P
K
G
V
L
L
Y
G
E
P
G
V
G
K
T
L
L
A
K
A
I
A
G
E
A
H
V
P
F
I
S
V
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
K
H
A
P
C
M
I
F
I
D
E
I
D
A
V
G
R
----------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
T
-
S
D
G
I
I
V
I
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
F
I
P
K
P
D
V
R
G
R
Y
E
I
L
K
V
H
A
R
--
N
K
K
L
A
--
K
D
V
D
L
E
F
V
A
R
A
T
P
G
L
T
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
K
-----------------
G
K
E
E
I
T
M
E
E
I
E
E
A
L
D
R
I
T
M
-------
T
I
S
P
K
E
K
E
K
I
A
I
H
E
A
G
H
A
L
M
G
L
V
S
D
D
D
D
K
V
H
K
I
S
I
I
P
------------
P
I
E
D
K
H
I
Y
D
K
K
D
L
Y
N
K
I
L
V
L
L
G
G
R
A
A
E
E
V
F
F
G
K
D
G
I
T
T
G
A
E
N
D
L
Q
R
A
T
D
L
A
Y
R
M
V
S
M
W
G
M
S
D
K
V
G
P
I
-
A
I
R
R
------------
D
--
T
-----
S
P
D
L
L
R
E
I
D
E
E
V
R
R
I
I
T
E
Q
Y
E
K
A
K
A
I
V
E
E
Y
K
E
P
L
K
A
V
V
K
K
L
L
E
K
E
T
I
T
C
E
E
F
V
E
V
F
K
L
Y
G
I
E
L
K
D
K
C
----------
4
PsiBlast_PDB
90.06
54%
-89
- C1 -
4WW0
2
FTSH_AQUAE
A:
[14-471]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
F
K
D
V
A
G
I
E
E
V
K
E
E
V
K
E
I
I
E
Y
-
L
K
-
D
P
V
K
F
Q
K
L
G
G
R
P
P
K
G
V
L
L
Y
G
E
P
G
V
G
K
T
L
L
A
K
A
I
A
G
E
A
H
V
P
F
I
S
V
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
K
H
A
P
C
M
I
F
I
D
E
I
D
A
V
G
R
-----------
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
T
-
S
D
G
I
I
V
I
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
F
I
P
K
P
D
V
R
G
R
Y
E
I
L
K
V
H
A
R
--
N
K
K
L
A
--
K
D
V
D
L
E
F
V
A
R
A
T
P
G
L
T
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
K
-----------------
G
K
E
E
I
T
M
E
E
I
E
E
A
L
D
R
I
T
M
-------
T
I
S
P
K
E
K
E
K
I
A
I
H
E
A
G
H
A
L
M
G
L
V
S
D
D
D
D
K
V
H
K
I
S
I
I
P
-----------------
H
I
Y
D
K
K
D
L
Y
N
K
I
L
V
L
L
G
G
R
A
A
E
E
V
F
F
G
K
D
G
I
T
T
G
A
E
N
D
L
Q
R
A
T
D
L
A
Y
R
M
V
S
M
W
G
M
S
D
K
V
G
P
I
-
A
I
R
R
------------
D
--
T
-----
S
P
D
L
L
R
E
I
D
E
E
V
R
R
I
I
T
E
Q
Y
E
K
A
K
A
I
V
E
E
Y
K
E
P
L
K
A
V
V
K
K
L
L
E
K
E
T
I
T
C
E
E
F
V
E
V
F
K
L
Y
G
I
E
L
K
D
K
C
K
K
--------
39
PsiBlast_CBE
89.56
54%
-90
- C1 -
4WW0
3
FTSH_AQUAE
C:
[14-470]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
F
K
D
V
A
G
I
E
E
V
K
E
E
V
K
E
I
I
E
Y
-
L
K
-
D
P
V
K
F
Q
K
L
G
G
R
P
P
K
G
V
L
L
Y
G
E
P
G
V
G
K
T
L
L
A
K
A
I
A
G
E
A
H
V
P
F
I
S
V
S
G
S
D
----
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
K
H
A
P
C
M
I
F
I
D
E
I
D
A
V
G
R
----------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
T
-
S
D
G
I
I
V
I
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
F
I
P
K
P
D
V
R
G
R
Y
E
I
L
K
V
H
A
R
--
N
K
K
L
A
--
K
D
V
D
L
E
F
V
A
R
A
T
P
G
L
T
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
K
-----------------
G
K
E
E
I
T
M
E
E
I
E
E
A
L
D
R
---------
M
T
I
S
P
K
E
K
E
K
I
A
I
H
E
A
G
H
A
L
M
G
L
V
S
D
D
D
D
K
V
H
K
I
S
I
I
P
---------------
D
K
H
I
Y
D
K
K
D
L
Y
N
K
I
L
V
L
L
G
G
R
A
A
E
E
V
F
F
G
K
D
G
I
T
T
G
A
E
N
D
L
Q
R
A
T
D
L
A
Y
R
M
V
S
M
W
G
M
S
D
K
V
G
P
I
-
A
I
R
-----------
A
V
D
--
T
-----
S
P
D
L
L
R
E
I
D
E
E
V
R
R
I
I
T
E
Q
Y
E
K
A
K
A
I
V
E
E
Y
K
E
P
L
K
A
V
V
K
K
L
L
E
K
E
T
I
T
C
E
E
F
V
E
V
F
K
L
Y
G
I
E
L
K
D
K
C
K
---------
5
PsiBlast_PDB
88.79
54%
-87
- C1 -
4Z8X
3
FTSH_AQUAE
A:
[14-471]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
F
K
D
V
A
G
I
E
E
V
K
E
E
V
K
E
I
I
E
Y
-
L
K
-
D
P
V
K
F
Q
K
L
G
G
R
P
P
K
G
V
L
L
Y
G
E
P
G
V
G
K
T
L
L
A
K
A
I
A
G
E
A
H
V
P
F
I
S
V
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
K
H
A
P
C
M
I
F
I
D
E
I
D
A
V
G
R
----------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
T
-
S
D
G
I
I
V
I
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
F
I
P
K
P
D
V
R
G
R
Y
E
I
L
K
V
H
A
R
--
N
K
K
L
A
--
K
D
V
D
L
E
F
V
A
R
A
T
P
G
L
T
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
K
-----------------
G
K
E
E
I
T
M
E
E
I
E
E
A
L
D
R
I
T
M
-------
T
I
S
P
K
E
K
E
K
I
A
I
H
E
A
G
H
A
L
M
G
L
V
S
D
D
D
D
K
V
H
K
I
S
I
I
P
------------
P
I
E
D
K
H
I
Y
D
K
K
D
L
Y
N
K
I
L
V
L
L
G
G
R
A
A
E
E
V
F
F
G
K
D
G
I
T
T
G
A
E
N
D
L
Q
R
A
T
D
L
A
Y
R
M
V
S
M
W
G
M
S
D
K
V
G
P
I
-
A
I
R
R
------------
D
--
T
-----
S
P
D
L
L
R
E
I
D
E
E
V
R
R
I
I
T
E
Q
Y
E
K
A
K
A
I
V
E
E
Y
K
E
P
L
K
A
V
V
K
K
L
L
E
K
E
T
I
T
C
E
E
F
V
E
V
F
K
L
Y
G
I
E
L
K
D
K
C
K
K
--------
40
PsiBlast_CBE
88.67
54%
-86
- C1 -
4WW0
2
FTSH_AQUAE
B:
[14-470]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
F
K
D
V
A
G
I
E
E
V
K
E
E
V
K
E
I
I
E
Y
-
L
K
-
D
P
V
K
F
Q
K
L
G
G
R
P
P
K
G
V
L
L
Y
G
E
P
G
V
G
K
T
L
L
A
K
A
I
A
G
E
A
H
V
P
F
I
S
V
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
K
H
A
P
C
M
I
F
I
D
E
I
D
A
V
G
R
----------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
T
-
S
D
G
I
I
V
I
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
F
I
P
K
P
D
V
R
G
R
Y
E
I
L
K
V
H
A
R
--
N
K
K
L
A
--
K
D
V
D
L
E
F
V
A
R
A
T
P
G
L
T
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
K
-----------------
G
K
E
E
I
T
M
E
E
I
E
E
A
L
D
R
I
--------
M
T
I
S
P
K
E
K
E
K
I
A
I
H
E
A
G
H
A
L
M
G
L
V
S
D
D
D
D
K
V
H
K
I
S
I
I
P
R
G
-
M
A
L
--------
E
D
K
H
I
Y
D
K
K
D
L
Y
N
K
I
L
V
L
L
G
G
R
A
A
E
E
V
F
F
G
K
D
G
I
T
T
G
A
E
N
D
L
Q
R
A
T
D
L
A
Y
R
M
V
S
M
W
G
M
S
D
K
V
G
P
I
-
A
I
R
-------------
D
--
T
-----
S
P
D
L
L
R
E
I
D
E
E
V
R
R
I
I
T
E
Q
Y
E
K
A
K
A
I
V
E
E
Y
K
E
P
L
K
A
V
V
K
K
L
L
E
K
E
T
I
T
C
E
E
F
V
E
V
F
K
L
Y
G
I
E
L
K
D
K
C
K
---------
38
PsiBlast_CBE
88.00
54%
-87
- C1 -
4Z8X
2
FTSH_AQUAE
B:
[14-471]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
F
K
D
V
A
G
I
E
E
V
K
E
E
V
K
E
I
I
E
Y
-
L
K
-
D
P
V
K
F
Q
K
L
G
G
R
P
P
K
G
V
L
L
Y
G
E
P
G
V
G
K
T
L
L
A
K
A
I
A
G
E
A
H
V
P
F
I
S
V
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
K
H
A
P
C
M
I
F
I
D
E
I
D
A
V
G
R
----------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
T
-
S
D
G
I
I
V
I
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
F
I
P
K
P
D
V
R
G
R
Y
E
I
L
K
V
H
A
R
--
N
K
K
L
A
--
K
D
V
D
L
E
F
V
A
R
A
T
P
G
L
T
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
K
-----------------
G
K
E
E
I
T
M
E
E
I
E
E
A
L
D
R
I
T
M
-------
T
I
S
P
K
E
K
E
K
I
A
I
H
E
A
G
H
A
L
M
G
L
V
S
D
D
D
D
K
V
H
K
I
S
I
I
P
------------
P
I
E
D
K
H
I
Y
D
K
K
D
L
Y
N
K
I
L
V
L
L
G
G
R
A
A
E
E
V
F
F
G
K
D
G
I
T
T
G
A
E
N
D
L
Q
R
A
T
D
L
A
Y
R
M
V
S
M
W
G
M
S
D
K
V
G
P
I
-
A
I
R
R
------------
D
--
T
-----
S
P
D
L
L
R
E
I
D
E
E
V
R
R
I
I
T
E
Q
Y
E
K
A
K
A
I
V
E
E
Y
K
E
P
L
K
A
V
V
K
K
L
L
E
K
E
T
I
T
C
E
E
F
V
E
V
F
K
L
Y
G
I
E
L
K
D
K
C
K
K
--------
104
HHSearch
85.39
54%
-86
- C1 -
2DHR
1
FTSH_THET8
A:
[18-475]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
V
L
T
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
-
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
G
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
--
G
K
P
L
A
--
E
D
V
D
L
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
-----------------
G
R
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
-
R
A
L
G
F
M
M
P
R
R
E
-
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
--
V
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
-
A
Y
A
V
R
E
D
T
Y
L
G
G
Y
D
V
R
Q
--
Y
-----
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
G
L
P
L
E
A
P
E
------------
2
PsiBlast_PDB
84.91
54%
-85
- C1 -
2DHR
1
FTSH_THET8
A:
[18-468]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
V
L
T
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
-
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
G
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
--
G
K
P
L
A
--
E
D
V
D
L
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
-----------------
G
R
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
-
R
A
L
G
F
M
M
P
R
R
E
-
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
--
D
D
V
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
-
A
Y
A
V
R
E
D
T
Y
L
G
--
G
Y
D
V
R
Q
Y
-----
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
G
L
P
L
E
A
P
E
------------
28
PsiBlast_CBE
84.33
54%
-88
- C1 -
2DHR
1
FTSH_THET8
E:
[18-468]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
V
L
T
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
-
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
G
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
--
G
K
P
L
A
--
E
D
V
D
L
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
-----------------
G
R
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
-
R
A
L
G
F
M
M
P
R
R
E
-
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
--
D
D
V
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
-
A
Y
A
V
R
E
D
T
Y
LG--
G
Y
D
V
RQ
Y
-----
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
G
L
P
L
E
A
P
E
------------
27
PsiBlast_CBE
84.19
54%
-83
- C1 -
2DHR
1
FTSH_THET8
F:
[18-468]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
V
L
T
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
-
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
--------
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
--
G
K
P
L
A
--
E
D
V
D
L
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
-----------------
G
R
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
-
R
A
L
G
F
M
M
P
R
R
E
-
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
--
D
D
V
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
-
A
Y
A
V
R
E
D
T
Y
LG--
G
Y
D
V
RQ
Y
-----
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
G
L
P
L
E
A
P
E
------------
31
PsiBlast_CBE
84.18
54%
-83
- C1 -
2DHR
1
FTSH_THET8
B:
[22-468]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
-
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
--------
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
--
G
K
P
L
A
--
E
D
V
D
L
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
-----------------
G
R
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
-
R
A
L
G
F
M
M
P
R
R
E
-
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
--
D
D
V
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
-
A
Y
A
V
R
E
D
T
Y
L
G
--
G
Y
D
V
R
Q
Y
-----
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
G
L
P
L
E
A
P
E
------------
33
PsiBlast_CBE
84.16
54%
-83
- C1 -
4EIW
1
FTSH_THET8
E:
[27-477]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
V
L
T
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
-
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
G
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
--
G
K
P
L
A
--
E
D
V
D
L
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
-----------------
G
R
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
-
R
A
L
G
F
M
M
P
R
R
E
-
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
--
D
D
V
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
-
A
Y
A
V
R
E
D
T
Y
LG--
G
Y
D
V
RQ
Y
-----
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
G
L
P
L
E
A
P
E
------------
12
PsiBlast_PDB
70.11
65%
-98
- C1 -
1IY1
1
FTSH_THET8
A:
[12-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
-
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
---------
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
--
G
K
P
L
A
--
E
D
V
D
L
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
-----------------
G
R
R
K
I
T
M
K
D
L
E
E
A
A
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
69.67
65%
-95
- C1 -
1IY0
1
FTSH_THET8
A:
[8-252]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
-
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
-------
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
--
G
K
P
L
A
--
E
D
V
D
L
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
-----------------
G
R
R
K
I
T
M
K
D
L
E
E
A
A
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
67.88
61%
-110
- C1 -
2R65
1
FTSH_HELPY
D:
[8-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
F
K
D
M
A
G
N
E
E
A
K
E
E
V
V
E
I
V
D
F
-
L
K
-
Y
P
E
R
Y
A
N
L
G
A
K
I
P
K
G
V
L
L
V
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
G
E
A
H
V
P
F
F
S
M
G
G
S
S
F
I
E
M
F
V
G
L
G
A
S
R
V
R
D
L
F
E
T
A
K
K
Q
A
P
S
I
I
F
I
D
E
I
D
A
I
G
K
---------
N
D
E
R
E
Q
T
L
N
Q
L
L
A
E
M
D
G
F
G
S
E
N
A
P
V
I
V
L
A
A
T
N
R
P
E
I
L
D
P
A
L
M
R
P
G
R
F
D
R
Q
V
L
V
D
K
P
D
F
N
G
R
V
E
I
L
K
V
H
I
K
--
G
V
K
L
A
--
N
D
V
N
L
Q
E
V
A
K
L
T
A
G
L
A
G
A
D
L
A
N
I
I
N
E
A
A
L
L
A
G
R
N
-----------------
N
Q
K
E
V
R
Q
Q
H
L
K
E
A
V
E
R
G
I
A
G
L
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
66.78
61%
-98
- C1 -
2R65
1
FTSH_HELPY
E:
[8-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
F
K
D
M
A
G
N
E
E
A
K
E
E
V
V
E
I
V
D
F
-
L
K
-
Y
P
E
R
Y
A
N
L
G
A
K
I
P
K
G
V
L
L
V
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
G
E
A
H
V
P
F
F
S
M
G
G
S
S
F
I
E
M
F
V
G
L
G
A
S
R
V
R
D
L
F
E
T
A
K
K
Q
A
P
S
I
I
F
I
D
E
I
D
A
I
G
K
---------
N
D
E
R
E
Q
T
L
N
Q
L
L
A
E
M
D
G
F
G
S
E
N
A
P
V
I
V
L
A
A
T
N
R
P
E
I
L
D
P
A
L
M
R
P
G
R
F
D
R
Q
V
L
V
D
K
P
D
F
N
G
R
V
E
I
L
K
V
H
I
K
--
G
V
K
L
A
--
N
D
V
N
L
Q
E
V
A
K
L
T
A
G
L
A
G
A
D
L
A
N
I
I
N
E
A
A
L
L
A
G
R
N
-----------------
N
Q
K
E
V
R
Q
Q
H
L
K
E
A
V
E
R
G
I
A
G
L
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
66.20
61%
-98
- C1 -
2R65
1
FTSH_HELPY
C:
[8-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
F
K
D
M
A
G
N
E
E
A
K
E
E
V
V
E
I
V
D
F
-
L
K
-
Y
P
E
R
Y
A
N
L
G
A
K
I
P
K
G
V
L
L
V
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
G
E
A
H
V
P
F
F
S
M
G
G
S
S
F
I
E
M
F
V
G
L
G
A
S
R
V
R
D
L
F
E
T
A
K
K
Q
A
P
S
I
I
F
I
D
E
I
D
A
I
G
K
---------
N
D
E
R
E
Q
T
L
N
Q
L
L
A
E
M
D
G
F
G
S
E
N
A
P
V
I
V
L
A
A
T
N
R
P
E
I
L
D
P
A
L
M
R
P
G
R
F
D
R
Q
V
L
V
D
K
P
D
F
N
G
R
V
E
I
L
K
V
H
I
K
--
G
V
K
L
A
--
N
D
V
N
L
Q
E
V
A
K
L
T
A
G
L
A
G
A
D
L
A
N
I
I
N
E
A
A
L
L
A
G
R
N
-----------------
N
Q
K
E
V
R
Q
Q
H
L
K
E
A
V
E
R
G
I
A
G
L
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
66.01
61%
-101
- C1 -
2R65
1
FTSH_HELPY
B:
[8-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
F
K
D
M
A
G
N
E
E
A
K
E
E
V
V
E
I
V
D
F
-
L
K
-
Y
P
E
R
Y
A
N
L
G
A
K
I
P
K
G
V
L
L
V
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
G
E
A
H
V
P
F
F
S
M
G
G
S
S
F
I
E
M
F
V
G
L
G
A
S
R
V
R
D
L
F
E
T
A
K
K
Q
A
P
S
I
I
F
I
D
E
I
D
A
I
G
K
---------
N
D
E
R
E
Q
T
L
N
Q
L
L
A
E
M
D
G
F
G
S
E
N
A
P
V
I
V
L
A
A
T
N
R
P
E
I
L
D
P
A
L
M
R
P
G
R
F
D
R
Q
V
L
V
D
K
P
D
F
N
G
R
V
E
I
L
K
V
H
I
K
--
G
V
K
L
A
--
N
D
V
N
L
Q
E
V
A
K
L
T
A
G
L
A
G
A
D
L
A
N
I
I
N
E
A
A
L
L
A
G
R
N
-----------------
N
Q
K
E
V
R
Q
Q
H
L
K
E
A
V
E
R
G
I
A
G
L
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
64.27
41%
-99
- C1 -
3HU3
2
TERA_HUMAN
A:
[197-455]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
N
E
V
G
Y
D
D
I
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
-
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
T
H
G
---
E
V
E
R
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
Q
-
R
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
--
N
M
K
L
A
--
D
D
V
D
L
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
K
M
DLIDLEDETID
A
E
V
M
N
S
L
A
V
T
M
D
D
F
R
W
A
L
S
Q
S
N
P
S
A
L
R
E
T
V
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
63.96
61%
-100
- C1 -
2R65
1
FTSH_HELPY
A:
[8-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
F
K
D
M
A
G
N
E
E
A
K
E
E
V
V
E
I
V
D
F
-
L
K
-
Y
P
E
R
Y
A
N
L
G
A
K
I
P
K
G
V
L
L
V
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
G
E
A
H
V
P
F
F
S
M
G
G
S
S
F
I
E
M
F
V
G
L
G
A
S
R
V
R
D
L
F
E
T
A
K
K
Q
A
P
S
I
I
F
I
D
E
I
D
A
I
G
K
---------
N
D
E
R
E
Q
T
L
N
Q
L
L
A
E
M
D
G
F
G
S
E
N
A
P
V
I
V
L
A
A
T
N
R
P
E
I
L
D
P
A
L
M
R
P
G
R
F
D
R
Q
V
L
V
D
K
P
D
F
N
G
R
V
E
I
L
K
V
H
I
K
--
G
V
K
L
A
--
N
D
V
N
L
Q
E
V
A
K
L
T
A
G
L
A
G
A
D
L
A
N
I
I
N
E
A
A
L
L
A
G
R
N
-----------------
N
Q
K
E
V
R
Q
Q
H
L
K
E
A
V
E
R
G
I
A
G
L
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
63.85
41%
-98
- C1 -
3HU3
3
TERA_HUMAN
B:
[197-455]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
N
E
V
G
Y
D
D
I
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
-
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
T
H
G
---
E
V
E
R
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
Q
-
R
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
--
N
M
K
L
A
--
D
D
V
D
L
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
KMDLIDLEDETIDAEVM
N
S
L
A
V
T
M
D
D
F
R
W
A
L
S
Q
S
N
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
63.75
46%
-90
- C1 -
3H4M
1
PAN_METJA
B:
[5-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
E
V
D
E
R
P
N
V
R
Y
E
D
I
G
G
L
E
K
Q
M
Q
E
I
R
E
V
V
E
L
P
L
K
-
H
P
E
L
F
E
K
V
G
I
E
P
P
K
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
T
E
T
N
A
T
F
I
R
V
V
G
S
E
L
V
K
K
F
I
G
E
G
A
S
L
V
K
D
I
F
K
L
A
K
E
K
A
P
S
I
I
F
I
D
E
I
D
A
I
A
A
K
R
T
D
A
L
T
G
G
D
R
E
V
Q
R
T
L
M
Q
L
L
A
E
M
D
G
F
D
A
-
R
G
D
V
K
I
I
G
A
T
N
R
P
D
I
L
D
P
A
I
L
R
P
G
R
F
D
R
I
I
E
V
P
A
P
D
E
K
G
R
L
E
I
L
K
I
H
T
R
--
K
M
N
L
A
--
E
D
V
N
L
E
E
I
A
K
M
T
E
G
C
V
G
A
E
L
K
A
I
C
T
E
A
G
M
N
A
I
R
E
-----------------
L
R
D
Y
V
T
M
D
D
F
R
K
A
V
E
K
I
M
E
K
K
K
V
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
63.55
41%
-96
- C1 -
1E32
1
TERA_MOUSE
A:
[197-455]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
N
E
V
G
Y
D
D
V
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
-
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
T
H
G
---
E
V
E
R
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
Q
-
R
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
--
N
M
K
L
A
--
D
D
V
D
L
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
KMDLIDLEDETID
A
E
V
M
N
S
L
A
V
T
M
D
D
F
R
W
A
L
S
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
63.54
41%
-97
- C1 -
4KO8
3
TERA_HUMAN
B:
[197-455]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
N
E
V
G
Y
D
D
I
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
-
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
T
H
G
---
E
V
E
R
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
Q
-
R
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
--
N
M
K
L
A
--
D
D
V
D
L
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
K
M
DLIDLEDETID
A
E
V
M
N
S
L
A
V
T
M
D
D
F
R
W
A
L
S
Q
S
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
63.53
41%
-98
- C1 -
4KO8
2
TERA_HUMAN
A:
[197-455]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
N
E
V
G
Y
D
D
I
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
-
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
T
H
G
---
E
V
E
R
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
Q
-
R
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
--
N
M
K
L
A
--
D
D
V
D
L
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
K
M
DLIDLEDETID
A
E
V
M
N
S
L
A
V
T
M
D
D
F
R
W
A
L
S
Q
S
N
P
S
A
L
R
E
T
V
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
HHSearch
63.32
51%
-102
- C1 -
2QZ4
1
A:
[2-255]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
F
K
D
V
A
G
M
H
E
A
K
L
E
V
R
E
F
V
D
Y
-
L
K
-
S
P
E
------
A
K
V
P
K
G
A
L
L
L
G
P
P
G
C
G
K
T
L
L
A
K
A
V
A
T
E
A
Q
V
P
F
L
A
M
A
G
A
E
F
V
E
V
I
G
G
L
G
A
A
R
V
R
S
L
F
K
E
A
R
A
R
A
P
C
I
V
Y
I
D
E
I
------------------
E
Q
T
L
N
Q
L
L
V
E
M
D
G
M
G
T
-
T
D
H
V
I
V
L
A
S
T
N
R
A
D
I
L
D
G
A
L
M
R
P
G
R
L
D
R
H
V
F
I
D
L
P
T
L
Q
E
R
R
E
I
F
E
Q
H
L
K
--
S
L
K
L
T
QS
S
T
F
Y
S
Q
R
L
A
E
L
T
P
G
F
S
G
A
D
I
A
N
I
C
N
E
A
A
L
H
-------------------------
V
H
T
L
N
F
E
Y
A
V
E
R
V
L
A
G
T
A
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
62.32
46%
-92
- C1 -
3H4M
1
PAN_METJA
C:
[5-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
E
V
D
E
R
P
N
V
R
Y
E
D
I
G
G
L
E
K
Q
M
Q
E
I
R
E
V
V
E
L
P
L
K
-
H
P
E
L
F
E
K
V
G
I
E
P
P
K
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
T
E
T
N
A
T
F
I
R
V
V
G
S
E
L
V
K
K
F
I
G
E
G
A
S
L
V
K
D
I
F
K
L
A
K
E
K
A
P
S
I
I
F
I
D
E
I
D
A
I
A
A
K
R
T
D
A
L
T
G
G
D
R
E
V
Q
R
T
L
M
Q
L
L
A
E
M
D
G
F
D
A
-
R
G
D
V
K
I
I
G
A
T
N
R
P
D
I
L
D
P
A
I
L
R
P
G
R
F
D
R
I
I
E
V
P
A
P
D
E
K
G
R
L
E
I
L
K
I
H
T
R
--
K
M
N
L
A
--
E
D
V
N
L
E
E
I
A
K
M
T
E
G
C
V
G
A
E
L
K
A
I
C
T
E
A
G
M
N
A
I
R
E
-----------------
L
R
D
Y
V
T
M
D
D
F
R
K
A
V
E
K
I
M
E
K
K
K
V
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
61.92
50%
-104
- C1 -
2QZ4
1
A:
[3-256]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
F
K
D
V
A
G
M
H
E
A
K
L
E
V
R
E
F
V
D
Y
-
L
K
-
S
P
E
------
A
K
V
P
K
G
A
L
L
L
G
P
P
G
C
G
K
T
L
L
A
K
A
V
A
T
E
A
Q
V
P
F
L
A
M
A
G
A
E
F
V
E
V
I
G
G
L
G
A
A
R
V
R
S
L
F
K
E
A
R
A
R
A
P
C
I
V
Y
I
D
E
I
------------------
E
Q
T
L
N
Q
L
L
V
E
M
D
G
M
G
T
-
T
D
H
V
I
V
L
A
S
T
N
R
A
D
I
L
D
G
A
L
M
R
P
G
R
L
D
R
H
V
F
I
D
L
P
T
L
Q
E
R
R
E
I
F
E
Q
H
L
K
S
L
K
L
T
Q
S
--
S
T
F
Y
S
Q
R
L
A
E
L
T
P
G
F
S
G
A
D
I
A
N
I
C
N
E
A
A
L
H
-------------------------
V
H
T
L
N
F
E
Y
A
V
E
R
V
L
A
G
T
A
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
61.44
46%
-89
- C1 -
3H4M
1
PAN_METJA
A:
[5-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
E
V
D
E
R
P
N
V
R
Y
E
D
I
G
G
L
E
K
Q
M
Q
E
I
R
E
V
V
E
L
P
L
K
-
H
P
E
L
F
E
K
V
G
I
E
P
P
K
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
T
E
T
N
A
T
F
I
R
V
V
G
S
E
L
V
K
K
F
I
G
E
G
A
S
L
V
K
D
I
F
K
L
A
K
E
K
A
P
S
I
I
F
I
D
E
I
D
A
I
A
A
K
R
T
D
A
L
T
G
G
D
R
E
V
Q
R
T
L
M
Q
L
L
A
E
M
D
G
F
D
A
-
R
G
D
V
K
I
I
G
A
T
N
R
P
D
I
L
D
P
A
I
L
R
P
G
R
F
D
R
I
I
E
V
P
A
P
D
E
K
G
R
L
E
I
L
K
I
H
T
R
--
K
M
N
L
A
--
E
D
V
N
L
E
E
I
A
K
M
T
E
G
C
V
G
A
E
L
K
A
I
C
T
E
A
G
M
N
A
I
R
E
-----------------
L
R
D
Y
V
T
M
D
D
F
R
K
A
V
E
K
I
M
E
K
K
K
V
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
Fugue
59.89
30%
-77
- C1 -
1E32
1
TERA_MOUSE
A:
[21-458]
NRPN
R
L
I
VDEAINEDNS
V
V
S
L
S
Q
P
K
M
D
E
L
Q
L
F
R
G
D
T
V
L
L
K
G
K
KR
R
E
A
V
C
I
V
L
S
D
D
T
C
S
D
E
K
I
R
M
N
R
V
V
R
N
N
L
R
V
R
L
G
D
V
I
S
I
Q
P
C
PD
V
K
Y
G
K
R
I
H
V
L
P
I
D
D
T
V
E
G
I
T
G
N
L
F
E
V
Y
L
K
P
Y
F
L
E
A
-
Y
R
P
I
R
K
G
D
I
F
L
V
R
G
G
M
R
A
V
E
F
K
V
V
E
T
D
P
S
P
Y
C
I
V
A
P
D
T
V
I
H
C
E
G
E
---
P
I
K
R
E
D
E
E
E
S
L
N
E
V
G
Y
D
D
V
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
-
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
T
---
H
G
E
V
E
R
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
Q
-
R
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
--
N
M
K
L
A
--
D
D
V
D
L
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
-----------------
K
M
D
L
I
D
L
E
D
E
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
A
E
V
M
N
S
L
A
V
T
M
D
D
F
R
W
A
L
S
Q
-------------------
120
HHSearch
58.79
44%
-84
- C1 -
3H4M
1
PAN_METJA
A:
[11-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
N
V
R
Y
E
D
I
G
G
L
E
K
Q
M
Q
E
I
R
E
V
V
E
L
-
P
L
K
H
P
E
L
F
E
K
V
G
I
E
P
P
K
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
T
E
T
N
A
T
F
I
R
V
V
G
S
E
L
V
K
K
F
I
G
E
G
A
S
L
V
K
D
I
F
K
L
A
K
E
K
A
P
S
I
I
F
I
D
E
I
D
A
I
A
A
K
R
T
D
A
L
T
G
G
D
R
E
V
Q
R
T
L
M
Q
L
L
A
E
M
D
G
F
D
A
-
R
G
D
V
K
I
I
G
A
T
N
R
P
D
I
L
D
P
A
I
L
R
P
G
R
F
D
R
I
I
E
V
P
A
P
D
E
K
G
R
L
E
I
L
K
I
H
T
R
--
K
M
N
L
A
--
E
D
V
N
L
E
E
I
A
K
M
T
E
G
C
V
G
A
E
L
K
A
I
C
T
E
A
G
M
N
A
I
R
E
-----------------
L
R
D
Y
V
T
M
D
D
F
R
K
A
V
E
K
I
M
E
K
K
K
V
--
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------