@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0160: (2015-11-28 )
MSTIRTTQMQVDHKTSLIIDAVEKFGGEVRLVGGCVRDSILQRKVHDIDLATNLLPSQVIEALKFHNIKAIPTGLKHGTITAVLNQRSFEITTLRHDVKCDGRHAKVEFTDNWRADASRRDFTFNALYANKYGHIYDYFGGTQDLKARRLNFIGNAEDRIKEDYLRILRAFRFHAKICIGDMSDKILNVCKKHAHKIYNLSGERIRDEMFKLLEYDAPVPTLKSMQKSDVLQKIIPKEVKCEILSSAFLFGTDALVKLALLLRTTEKNDRLSLGEYVSKFLRLSNKQKKKLLFLLSNNIKTELTEKEQRKYISLLGKELYCDLVKVCGVESGANVDEYISLAQVLNIQKFPLSGDDLINIGYQPGKNLGRNLKLLRQHWEDSSYTLTKKELMLYAKSLL
Atome Classification :
(20 SA)
------.........10--........20....----....30........40....---....50........60.....-...70-..-....-------.--.80...-.----....90....-....100.-......110.----......120.......----130-.---------..-.....140.......150.......160.......170......--.--180.......190..--.--....200.......210..-----------..---..---.220.......230..-..-----..---------.240----..-------....----.--------250--------------------------.--......----------..260-----.......270------------.........280.......290......---.300----.----------........310.......320-......---.330--.--.----...---....340.-------......350........360........370.......380.......390.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------MST
I
R
T
T
Q
M
Q
V--DH
K
T
S
L
I
I
D
A
V
E
K
F----GG
E
V
R
L
V
G
G
C
V
R
D
S
I
L
Q
R
K
V
---
H
D
I
D
L
A
T
NL
L
P
S
Q
V
I
E
A
L
K
FH-NIKAI-PT-GLKH-------G--
T
I
T
A
V
L
-N----QR
S
F
E
I
T
T
L
R
-
H
DVKCDG
R
-
H
A
K
V
E
FTDNW----RADASRR
D
F
T
F
N
A
L
YA----N-K-Y---------G
H
-
I
Y
DYFGGT
Q
D
L
K
A
R
R
L
NFIGN
A
E
D
R
I
K
E
D
Y
L
R
I
L
R
A
F
R
F
H
A
K
I
C
--I--GD
M
S
D
K
I
L
N
V
C
K
K
H
A
--
H
--
K
IYNL
S
G
E
R
I
R
D
E
M
F
K
L
L
E-----------YD---AP---V
P
T
L
K
S
M
Q
K
S
D
V
L
Q
K
I-I
P
-----
K
E
---------
V
K
C
E
----
I
L
-------
S
S
A
F
----
L
--------
F
----------------------------
G
--
T
D
A
L
V
K
----------
L
A
L
L
L
-----RTTEKNDR--------------L
S
L
G
E
Y
V
S
K
F
L
R
LSNKQ
K
K
K
L
L
F
L
LSNN---IK------T----------EL
T
E
K
E
Q
R
K
Y
I
S
L
L
G
K
E
L
Y
C
D
-
L
V
K
VCG---VE----S--G----A
N
V
---
D
E
Y
I
S
L
A
Q
-------
V
LNIQKF-PLSGD
D
L
I
N
I-GYQPGKNL
G
R
N
L
K
L
L
R
Q
HWEDSS
Y
T
L
T
K
K
E
L
M
L
Y
A
K
S
LL
21
PsiBlast_CBE
94.55
35%
-83
- C5 -
4X4W
10
TRNT1_HUMAN
B:
[32-409]
---------------------------------------
E
L
R
I
A
G
G
A
V
R
D
L
L
N
G
V
K
P
---
Q
D
I
D
F
A
T
T
A
T
P
T
Q
M
K
E
M
F
Q
S
A
-
G
I
R
M
I
-
N
-------------
G
--
T
I
T
A
R
L
-
H
----
E
E
N
F
E
I
T
T
L
R
-
I
D
V
T
T
D
----
A
E
V
E
F
T
T
D
W
----
Q
K
D
A
E
R
R
D
L
T
I
N
S
M
F
L
----
G
-
F
-
D
---------
G
T
-
L
F
D
Y
F
N
G
Y
E
D
L
K
N
K
K
V
R
F
V
G
H
A
K
Q
R
I
Q
E
D
Y
L
R
I
L
R
Y
F
R
F
Y
G
R
I
V
DK
P
--
G
D
H
D
P
E
T
L
E
A
I
A
E
N
A
--
K
--
G
L
A
G
I
S
G
E
R
I
W
V
E
L
K
K
I
L
V
-----------
G
N
---
H
V
---
N
H
L
I
H
L
I
Y
D
L
D
V
A
P
Y
I
G
L
P
-----
A
N
---------
A
S
L
E
E
F
D
K
V
S
-------
K
N
V
D
----
G
--------
F
----------------------------
S
--
P
K
P
V
T
L
----------
L
A
S
L
F
-----
K
V
Q
D
D
V
T
K
--------------
L
D
L
R
------
L
K
I
A
K
E
E
K
N
L
G
L
F
I
V
K
N
R
KDL
I
K
------
A
----------
T
D
S
S
D
P
L
K
P
Y
Q
D
F
I
I
D
S
---
D
A
T
T
R
V
C
E
---
L
L
----
K
--
Y
----
Q
G
E
---
H
C
L
L
K
E
M
Q
-------
Q
W
S
I
P
P
F
-
P
V
S
G
H
D
I
R
K
V
-
G
I
S
S
G
K
E
I
G
A
L
L
Q
Q
L
R
E
Q
W
K
K
S
G
Y
Q
M
E
K
D
E
L
L
S
Y
I
K
K
T
L
31
HHSearch
85.84
25%
-79
- C5 -
1MIW
2
CCA_GEOSE
A:
[2-396]
--------------
K
P
P
--
F
Q
E
A
L
G
I
I
Q
Q
L
K
Q
H
----
G
Y
D
A
Y
F
V
G
G
A
V
R
D
L
L
L
G
R
P
I
---
G
D
V
D
I
A
T
S
A
L
P
E
D
V
M
A
I
F
P
-----
K
T
I
-
D
V
-
G
S
K
H
-------
G
--
T
V
V
V
V
H
-
K
----
G
K
A
Y
E
V
T
T
F
K
-
T
D
G
--------
S
V
T
F
V
R
S
L
----
E
E
D
L
K
R
R
D
F
T
M
N
A
I
A
M
----
D
-
E
-
Y
---------
G
T
-
I
I
D
P
F
G
G
R
E
A
I
R
R
R
I
I
R
T
V
G
E
A
E
K
R
F
R
E
D
A
L
R
M
M
R
A
V
R
F
V
S
E
L
G
--
F
--
A
-
L
A
P
D
T
E
Q
A
I
V
Q
N
A
--
P
--
L
L
A
H
I
S
V
E
R
M
T
M
E
M
E
K
L
L
G
-----------
G
P
---
F
A
---
A
R
A
L
P
L
L
A
E
T
G
L
N
A
-
Y
-
L
P
-----
G
L
---------
A
G
K
E
----
K
Q
L
R
L
----
A
A
A
Y
----
R
--------
W
----------------------------
P
WL
A
A
R
E
E
R
----------
W
A
L
L
C
-----
H
A
L
G
V
Q
------------------
E
S
R
P
F
L
R
A
W
K
L
P
N
K
V
V
D
E
A
G
A
I
L
T
A
L
---
A
D
I
PR---
P
E---------
A
W
T
N
E
Q
L
F
S
----
A
G
L
E
R
A
L
S
-
V
E
T
V
R
A
A
F
T
G
A
----
P
--
P
G
P
W
H
E
K
L
---
R
R
R
F
A
S
L
P
-------
I
K
T
K
G
E
L
-
A
V
N
G
K
D
V
I
E
W
V
G
K
P
A
G
P
W
V
K
E
A
L
D
A
I
W
R
A
V
V
N
G
E
V
E
N
E
K
E
R
I
Y
A
W
L
M
E
R
N
55
Fugue
81.59
30%
-75
- C5 -
1OU5
-
TRNT1_HUMAN
A:
[-1-354]
------
K
M
K
L
Q
S
P
E
F
Q
S
LF
T
E
G
L
K
S
L
T
E
L
F
V
K
E
----
N
H
E
L
R
I
A
G
G
A
V
R
D
L
L
N
G
V
K
P
---
Q
D
I
D
F
A
T
T
A
T
P
T
Q
M
K
E
M
F
Q
S
A
-
G
I
R
M
I
N
N
R
-
G
E
K
H
-------
G
--
T
I
T
A
R
L
-
H
----
E
E
N
F
E
I
T
T
L
R
--------------
I
F
T
T
D
W
----
Q
K
D
A
E
R
R
D
L
T
I
N
S
M
F
L
----
G
-
F
-
D
---------
G
T
-
L
F
D
Y
F
N
G
Y
E
D
L
K
N
K
K
V
R
F
V
G
H
A
K
Q
R
I
Q
E
D
Y
L
R
I
L
R
Y
F
R
F
Y
G
R
I
V
--
D
KP
G
D
H
D
P
E
T
L
E
A
I
A
E
N
A
--
K
--
G
L
A
G
I
S
G
E
R
I
W
V
E
L
K
K
I
L
V
-----------
G
N
---
H
V
---
N
H
L
I
H
L
I
Y
D
L
D
V
A
P
Y
I
-
G
L
PANAS
L
E
---------
E
F
D
K
----
V
S
-------
K
N
V
D
----
G
--------
F
----------------------------
S
--
P
K
P
V
T
L
----------
L
A
S
L
F
-----
K
V
Q
D
D
V
--------------------
T
K
L
D
L
R
L
K
I
A
K
E
E
K
N
L
G
L
F
I
V
K
N
R
---
K
D
------
L
----------
I
K
A
T
D
S
S
D
P
L
K
P
Y
Q
D
F
I
I
D
S
R
-------------------------
E
P
---
D
A
T
T
R
V
C
E
-------
L
L
K
Y
Q
G
-----------------
E
H
C
L
L
K
E
M
Q
----
Q
W
S
I
------------------
56
Fugue
78.95
24%
-69
- C5 -
3AQL
2
?
A:
[1-411]
QVTVIP
R
E
Q
H
A
I
S
R
K
D
I
--
S
E
N
A
L
K
V
M
Y
R
L
N
K
A
----
G
Y
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
P
---
K
D
F
D
V
T
T
N
A
T
P
E
Q
V
R
K
L
--
F
R
-
N
C
R
L
V
-
G
R
-
R
F
R
L
-------
A
--
H
V
M
--
F
-
G
----
P
E
I
I
E
V
A
T
F
R
-
G
N
I
F
------------
G
S
I
----
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
Y
----
S
V
A
-
D
---------
F
T
-
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
L
I
G
N
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
G
--
M
---
R
I
S
P
E
T
A
E
P
I
P
R
L
A
--
T
--
L
L
N
D
I
P
P
A
H
L
F
E
E
S
L
K
L
L
Q
-----------
A
G
---
Y
G
---
Y
E
T
Y
K
L
L
C
E
Y
H
L
F
Q
P
L
-
F
P
-----
T
I
T
R
Y
FTENGD
S
P
M
E
----
R
I
-------
I
E
Q
V
----
L
--------
K
----------------------------
N
--
T
D
T
R
I
H
N
DMRVN
P
A
F
L
F
A
A
M
F
------------
W
--------------
Y
P
L
L
E
T
A
Q
K
I
A
Q
E
S
G
L
T
Y
H
D
A
F
A
L
A
M
N
D
---
V
L
------
D
----------
E
A
C
R
S
L
A
I
P
------
K
R
L
T
T
L
-
T
R
D
I
W
Q
---
L
Q
----
L
--
R
----
M
S
R
---
R
Q
G
K
R
A
W
K
-------
L
L
E
H
P
K
F
-
R
-
A
A
Y
D
L
L
A
L
-
R
A
E
V
E
R
N
--
A
E
L
Q
R
L
V
K
W
W
G
E
F
Q
V
S
A
P
P
D
Q
K
G
M
L
-----
1
PsiBlast_PDB
76.15
34%
-69
- C5 -
1OU5
-
TRNT1_HUMAN
A:
[29-354]
---------------------------------------
E
L
R
I
A
G
G
A
V
R
D
L
L
N
G
V
K
P
---
Q
D
I
D
F
A
T
T
A
T
P
T
Q
M
K
E
M
F
Q
S
A
-
G
I
R
M
I
-
N
N
R
G
E
K
H
-------
G
--
T
I
T
A
R
L
-
H
----
E
E
N
F
E
I
T
T
L
R
-
I
-------------
F
T
T
D
W
----
Q
K
D
A
E
R
R
D
L
T
I
N
S
M
F
L
----
G
-
F
-
D
---------
G
T
-
L
F
D
Y
F
N
G
Y
E
D
L
K
N
K
K
V
R
F
V
G
H
A
K
Q
R
I
Q
E
D
Y
L
R
I
L
R
Y
F
R
F
Y
G
R
I
V
DK
P
--
G
D
H
D
P
E
T
L
E
A
I
A
E
N
A
--
K
--
G
L
A
G
I
S
G
E
R
I
W
V
E
L
K
K
I
L
V
GNH
V
N
H
L
I
H
L
I
Y
D
L
DV
A
P
YIG
L
P
A
N
A
S
L
E
E
F
D
K
V
S
K
N
-
V
D
-----
G
--------------------------------------------
F
----------------------------
S
--
P
K
P
V
T
L
----------
L
A
S
L
F
-----
K
V
Q
D
D
V
T
K
--------------
L
D
L
R
------
L
K
I
A
K
E
E
K
N
L
G
L
F
I
V
K
N
R
KDL
I
K
------
A
----------
T
D
S
S
D
P
L
K
P
Y
Q
D
F
I
I
D
S
R
E
P
D
A
T
T
R
V
C
E
---
L
L
----
K
--
Y
----
Q
G
E
---
H
C
L
L
K
E
M
Q
-------
Q
W
S
I
------------------------------------------------------
33
HHSearch
75.45
22%
-91
* C5 *
3WFO
4
?
A:
[24-448]
----------------------
F
D
D
V
A
K
V
L
-
P
R
----
E
H
Y
C
F
I
V
G
G
W
V
R
D
R
I
L
G
E
P
V
GY
N
I
D
V
D
F
L
T
T
A
D
P
V
E
L
A
K
N
F
A
K
R
I
G
G
H
F
F
-
V
F
-
E
-----------P
T
I
A
S
V
V
L
-
H
L
PP
Y
R
Y
R
F
D
F
S
P
L
K
-
G
K
D
-----------
L
E
K
A
L
----
I
E
D
L
K
E
R
D
F
T
A
N
A
I
A
V
----
N
-
L
-
D
D
V
L
SIGA
K
Q
T
I
-
V
Y
D
P
T
G
G
I
K
D
L
E
Q
G
L
L
R
P
V
--
S
I
E
N
L
K
R
D
P
V
R
V
L
R
G
F
R
I
A
I
E
K
N
--
L
--
Q
-
L
T
E
D
F
Y
E
F
V
K
E
D
P
--
R
--
I
V
L
K
S
A
V
E
R
I
T
H
E
L
F
K
I
M
K
-----------
E
K
---
T
A
---
H
K
V
I
R
E
L
Y
E
Y
G
V
L
E
A
I
-
I
P
-----
E
I
---------
G
R
L
R
----
E
V
KDP
L
D
--
E
H
T
L
K
T
L
E
Y
--------
L
E
Q
V
I
E
D
RAKYLS
A
E
L
L
E
N
FGKKRVLGEF
T
--
D
V
E
L
L
K
----------
W
G
A
L
F
-----
H
D
I
G
K
P
Q
T
FVTFYE
H
D
K
V
G
---
A
Q
I
V
R
E
I
G
E
R
L
R
W
G
D
E
A
T
E
F
V
A
K
L
V
R
H
H
---
L
R
------
P
F
F
L
R
E
A
F
K
K
G
E
L
K
R
R
G
M
A
N
F
W
R
E
C
G
D
-
I
A
P
H
-
L
F
L
L
S
I
---
A
D
A
M
A
S
G
DE
E
----
E
D
I
K
A
L
M
E
T
I
A
E
L
E
S
F
N
R
NEM
K
---------------------------------------------------------
32
HHSearch
73.40
22%
-58
- C5 -
3H38
-
?
A:
[10-423]
-----------
L
L
V
E
R
V
--
D
P
K
I
L
N
L
F
R
L
L
G
K
F
G
D
E
V
N
M
P
V
Y
V
V
G
G
F
V
R
D
L
L
L
G
I
K
N
---
L
D
I
D
I
V
V
E
G
N
A
L
E
F
A
E
Y
A
K
R
F
-
L
P
G
K
L
-
V
K
-
H
D
K
F
-------
M
--
T
A
S
L
F
L
K
G
----
G
L
R
I
D
I
A
T
A
R
-
L
E
Y
Y
E
S
P
A
K
L
P
D
V
E
M
S
-
T
I
----
K
K
D
L
Y
R
R
D
F
T
I
N
A
M
A
I
----
K
-
L
-
N
PKDF-----
G
L
-
L
I
D
F
F
G
G
Y
R
D
L
K
E
G
V
I
R
V
L
H
--
T
L
S
F
V
D
D
P
T
R
I
L
R
A
I
R
F
E
Q
R
F
D
--
F
--
R
-
I
E
E
T
T
E
R
L
L
K
Q
A
V
E
E
G
--
Y
L
E
R
T
T
G
P
R
L
R
Q
E
L
E
K
I
L
E
-----------
E
K
---
N
P
---
L
K
S
I
R
R
M
A
Q
F
D
V
I
K
H
L
-
F
P
-----
K
T
---------
Y
Y
T
P
----
S
M
D
E
K
M
---
E
N
L
F
----
R
N
I
P
W
V
E
--
E
----------------------------
N
--
F
G
E
V
D
R
----------
F
Y
A
V
L
-----
H
V
F
L
E
F
Y
D
--------------
D
E
S
W
K
E
V
R
D
R
Y
S
L
R
R
N
L
I
N
E
I
R
H
V
E
K
S
A
---
P
A
L
L
E
M
L
S
E
----------
R
V
P
A
S
F
V
Y
P
L
V
K
G
V
S
N
E
T
I
C
H
-
F
L
A
Y
L
-----
S
----
G
-------
E
K
E
---
G
L
F
K
S
Y
L
L
-------
K
I
K
N
T
K
L
E
K
I
N
G
E
Y
L
I
R
K
-
G
I
T
S
G
K
I
I
G
E
V
L
E
K
I
L
M
K
K
L
D
G
D
T
R
D
-
E
E
E
I
L
E
E
V
L
A
S
L
34
HHSearch
71.13
24%
-93
- C5 -
3AQL
2
?
A:
[13-351]
------------
S
R
K
D
I
--
S
E
N
A
L
K
V
M
Y
R
L
N
K
A
----
G
Y
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
P
---
K
D
F
D
V
T
T
N
A
T
P
E
Q
V
R
K
L
F
R
-----
N
C
R
-
L
V
-
G
R
R
F
-------
R
--
L
A
H
V
M
F
-
G
----
P
E
I
I
E
V
A
T
F
R
-
G
------------
N
I
F
G
S
I
----
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
Y
----
S
-
V
A
D
---------
F
T
-
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
L
I
G
N
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
G
--
M
--
R
-
I
S
P
E
T
A
E
P
I
P
R
L
A
--
T
--
L
L
N
D
I
P
P
A
H
L
F
E
E
S
L
K
L
L
Q
-----------
A
G
---
Y
G
---
Y
E
T
Y
K
L
L
C
E
Y
H
L
F
Q
P
L
-
F
P
-----
T
I
---------
T
R
Y
F
----
T
E
NGDS
P
M
E
R
I
I
E
Q
V
L
K
N
T
D
T
R
I
H
N
D
M
----------------------------
R
--
V
N
P
A
F
L
----------
F
A
A
M
F
W
Y
P
L
L
E
T
A
Q
K
I
A
Q
E
S
GLT
Y
H
D
A
F
A
L
A
M
N
D
V
L
D
E
A
C
R
S
L
A
I
P
K
R
L
T
T
L
T
R
D
I
W
Q
L
Q
---
L
R
------
M
----------
S
R
R
Q
G
K
R
A
W
K
L
L
E
H
P
K
F
R
A
A
Y
-
D
L
L
A
L
R
---
A
E
----
V
--
E
----
R
N
A
---
E
L
Q
R
L
V
K
W
-------
W
G
E
F
Q
V
S
-
A
P
P
D
Q
K
G
M
L
-----------------------------------------
7
PsiBlast_PDB
68.71
31%
-101
- C5 -
3AQN
2
?
A:
[28-250]
-----------------------------
L
N
K
A
----
G
Y
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
P
---
K
D
F
D
V
T
T
N
A
T
P
E
Q
V
R
K
L
--
F
R
-
N
C
R
L
V
----
G
R
R
F
-------
R
--
L
A
H
V
M
F
-
G
----
P
E
I
I
E
V
A
T
F
R
G-----------------
N
I
FGS
I
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
Y
----
S
-
V
-
A
---------
D
F
T
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
L
I
G
N
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
G
--
M
---
R
I
S
P
E
T
A
E
P
I
P
R
L
A
--
T
--
L
L
N
D
I
P
P
A
H
L
F
E
E
S
L
K
L
L
Q
-----------
A
G
---
Y
G
---
Y
E
T
Y
K
L
L
C
E
Y
H
L
F
Q
P
L
-
F
P
-----
T
I
---------
T
R
Y
F
----
T
E
-------
N
G
D
S
----
P
--------
M
----------------------------
E
--
R
I
I
E
Q
V
----------
L
K
N
T
D
-----
T
R
I
H
N
D
M
R
--------------
V
N
P
A
F
L
F
A
A
M
F
W
Y
P
L
L
E
T
A
Q
K
I
A
Q
E
S
G
L
---
T
Y
------
H
----------
D
A
F
A
L
A
M
N
D
V
L
D
E
A
C
R
S
L
A
I
P
-
K
R
L
T
T
L
---
T
R
----
D
--
I
----
W
Q
L
---
Q
L
R
M
S
R
R
Q
-------
G
K
R
A
W
K
L
-
L
E
H
P
K
F
R
A
A
Y
-
D
L
L
A
L
R
A
E
V
E
R
N
A
E
L
Q
R
L
V
K
W
W
G
E
F
Q
V
S
A
P
P
D
Q
K
G
M
L
--
5
PsiBlast_PDB
68.48
31%
-99
- C5 -
3AQM
1
?
A:
[28-250]
-----------------------------
L
N
K
A
----
G
Y
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
P
---
K
D
F
D
V
T
T
N
A
T
P
E
Q
V
R
K
L
--
F
R
-
N
C
R
L
V
----
G
R
R
F
-------
R
--
L
A
H
V
M
F
-
G
----
P
E
I
I
E
V
A
T
F
R
G-----------------
N
I
FGS
I
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
Y
----
S
-
V
-
A
---------
D
F
T
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
L
I
G
N
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
G
--
M
---
R
I
S
P
E
T
A
E
P
I
P
R
L
A
--
T
--
L
L
N
D
I
P
P
A
R
L
F
E
E
S
L
K
L
L
Q
-----------
A
G
---
Y
G
---
Y
E
T
Y
K
L
L
C
E
Y
H
L
F
Q
P
L
-
F
P
-----
T
I
---------
T
R
Y
F
----
T
E
-------
N
G
D
S
----
P
--------
M
----------------------------
E
--
R
I
I
E
Q
V
----------
L
K
N
T
D
-----
T
R
I
H
N
D
M
R
--------------
V
N
P
A
F
L
F
A
A
M
F
W
Y
P
L
L
E
T
A
Q
K
I
A
Q
E
S
G
L
---
T
Y
------
H
----------
D
A
F
A
L
A
M
N
D
V
L
D
E
A
C
R
S
L
A
I
P
-
K
R
L
T
T
L
---
T
R
----
D
--
I
----
W
Q
L
---
Q
L
R
M
S
R
R
Q
-------
G
K
R
A
W
K
L
-
L
E
H
P
K
F
R
A
A
Y
-
D
L
L
A
L
R
A
E
V
E
R
N
A
E
L
Q
R
L
V
K
W
W
G
E
F
Q
V
S
A
P
P
D
Q
K
G
M
L
--
24
PsiBlast_CBE
68.36
31%
-97
- C5 -
3AQN
1
?
B:
[28-250]
-----------------------------
L
N
K
A
----
G
Y
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
P
---
K
D
F
D
V
T
T
N
A
T
P
E
Q
V
R
K
L
--
F
R
-
N
C
R
L
V
----
G
R
R
F
-------
R
--
L
A
H
V
M
F
-
G
----
P
E
I
I
E
V
A
T
F
R
G-----------------
N
I
FGSI
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
Y
----
S
-
V
-
A
---------
D
F
T
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
L
I
G
N
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
G
--
M
---
R
I
S
P
E
T
A
E
P
I
P
R
L
A
--
T
--
L
L
N
D
I
P
P
A
H
L
F
E
E
S
L
K
L
L
Q
-----------
A
G
---
Y
G
---
Y
E
T
Y
K
L
L
C
E
Y
H
L
F
Q
P
L
-
F
P
-----
T
I
---------
T
R
Y
F
----
T
E
-------
N
G
D
S
----
P
--------
M
----------------------------
E
--
R
I
I
E
Q
V
----------
L
K
N
T
D
-----
T
R
I
H
N
D
M
R
--------------
V
N
P
A
F
L
F
A
A
M
F
W
Y
P
L
L
E
T
A
Q
K
I
A
Q
E
S
G
L
---
T
Y
------
H
----------
D
A
F
A
L
A
M
N
D
V
L
D
E
A
C
R
S
L
A
I
P
-
K
R
L
T
T
L
---
T
R
----
D
--
I
----
W
Q
L
---
Q
L
R
M
S
R
R
Q
-------
G
K
R
A
W
K
L
-
L
E
H
P
K
F
R
A
A
Y
-
D
L
L
A
L
R
A
E
V
E
R
N
A
E
L
Q
R
L
V
K
W
W
G
E
F
Q
V
S
A
P
P
D
Q
K
G
M
L
--
25
PsiBlast_CBE
68.26
31%
-95
- C5 -
3AQL
2
?
B:
[28-250]
-----------------------------
L
N
K
A
----
G
Y
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
P
---
K
D
F
D
V
T
T
N
A
T
P
E
Q
V
R
K
L
--
F
R
-
N
C
R
L
V
----
G
R
R
F
-------
R
--
L
A
H
V
M
F
-
G
----
P
E
I
I
E
V
A
T
F
R
G-----------------
N
I
FGSI
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
Y
----
S
-
V
-
A
---------
D
F
T
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
L
I
G
N
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
G
--
M
---
R
I
S
P
E
T
A
E
P
I
P
R
L
A
--
T
--
L
L
N
D
I
P
P
A
H
L
F
E
E
S
L
K
L
L
Q
-----------
A
G
---
Y
G
---
Y
E
T
Y
K
L
L
C
E
Y
H
L
F
Q
P
L
-
F
P
-----
T
I
---------
T
R
Y
F
----
T
E
-------
N
G
D
S
----
P
--------
M
----------------------------
E
--
R
I
I
E
Q
V
----------
L
K
N
T
D
-----
T
R
I
H
N
D
M
R
--------------
V
N
P
A
F
L
F
A
A
M
F
W
Y
P
L
L
E
T
A
Q
K
I
A
Q
E
S
G
L
---
T
Y
------
H
----------
D
A
F
A
L
A
M
N
D
V
L
D
E
A
C
R
S
L
A
I
P
-
K
R
L
T
T
L
---
T
R
----
D
--
I
----
W
Q
L
---
Q
L
R
M
S
R
R
Q
-------
G
K
R
A
W
K
L
-
L
E
H
P
K
F
R
A
A
Y
-
D
L
L
A
L
R
A
E
V
E
R
N
A
E
L
Q
R
L
V
K
W
W
G
E
F
Q
V
S
A
P
P
D
Q
K
G
M
L
--
35
HHSearch
67.56
21%
-86
- C5 -
3WFP
1
?
A:
[5-332]
----------------
Y
--
L
S
Y
F
D
D
V
A
K
V
L
-
P
R
----
E
H
Y
C
F
I
V
G
G
W
V
R
D
R
I
L
G
E
P
V
GY
N
I
D
V
D
F
L
T
T
A
D
P
V
E
L
A
K
N
F
A
K
R
I
G
G
H
F
F
-
V
F
-
E
-
K
R
G
FLIK
R
P
T
--
I
A
S
V
V
L
-
H
L
PP
Y
R
Y
R
F
D
F
S
P
L
K
-
G
K
-----------
D
L
E
K
A
L
----
I
E
D
L
K
E
R
D
F
T
A
N
A
I
A
V
----
N
-
L
-
D
D
V
L
SIGAKQ
T
I
-
V
Y
D
P
T
G
G
I
K
D
L
E
Q
G
L
L
R
P
V
S
--
I
E
N
L
K
R
D
P
V
R
V
L
R
G
F
R
I
A
I
E
K
N
--
L
--
Q
-
L
T
E
D
F
Y
E
F
V
K
E
D
P
--
R
--
I
V
L
K
S
A
V
E
R
I
T
H
E
L
F
K
I
M
K
-----------
E
K
---
T
A
---
H
K
V
I
R
E
L
Y
E
Y
G
V
L
E
A
I
-
I
P
-----
E
I
---------
G
R
L
R
----
E
V
KDP
L
D
--
E
H
T
L
K
T
L
E
Y
--------
L
E
Q
V
I
E
D
RAKYLS
A
E
L
L
E
N
FGKKRVLGEF
T
--
D
V
E
L
L
K
----------
W
G
A
L
F
-----
H
D
I
G
K
P
Q
T
FVTFYE
H
D
K
V
G
---
A
Q
I
V
R
E
I
G
E
R
L
R
W
G
D
E
A
T
E
F
V
A
K
L
V
R
H
H
---
L
R
------
P
F
F
L
R
E
A
F
K
K
G
E
L
K
R
R
G
M
A
N
F
W
R
E
C
G
-
D
I
A
P
H
-
L
F
L
L
S
I
---
A
D
----
A
--
M
----
A
S
G
---
D
E
E
E
D
I
K
A
-------
L
M
E
T
I
A
E
-
L
E
S
F
N
R
N
E
M
K
-
E
E
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
N
K
U
6
PsiBlast_PDB
67.52
31%
-101
- C5 -
3AQL
2
?
A:
[28-250]
-----------------------------
L
N
K
A
----
G
Y
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
P
---
K
D
F
D
V
T
T
N
A
T
P
E
Q
V
R
K
L
--
F
R
-
N
C
R
L
V
----
G
R
R
F
-------
R
--
L
A
H
V
M
F
-
G
----
P
E
I
I
E
V
A
T
F
R
G-----------------
N
I
FGS
I
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
Y
----
S
-
V
-
A
---------
D
F
T
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
L
I
G
N
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
G
--
M
---
R
I
S
P
E
T
A
E
P
I
P
R
L
A
--
T
--
L
L
N
D
I
P
P
A
H
L
F
E
E
S
L
K
L
L
Q
-----------
A
G
---
Y
G
---
Y
E
T
Y
K
L
L
C
E
Y
H
L
F
Q
P
L
-
F
P
-----
T
I
---------
T
R
Y
F
----
T
E
-------
N
G
D
S
----
P
--------
M
----------------------------
E
--
R
I
I
E
Q
V
----------
L
K
N
T
D
-----
T
R
I
H
N
D
M
R
--------------
V
N
P
A
F
L
F
A
A
M
F
W
Y
P
L
L
E
T
A
Q
K
I
A
Q
E
S
G
L
---
T
Y
------
H
----------
D
A
F
A
L
A
M
N
D
V
L
D
E
A
C
R
S
L
A
I
P
-
K
R
L
T
T
L
---
T
R
----
D
--
I
----
W
Q
L
---
Q
L
R
M
S
R
R
Q
-------
G
K
R
A
W
K
L
-
L
E
H
P
K
F
R
A
A
Y
-
D
L
L
A
L
R
A
E
V
E
R
N
A
E
L
Q
R
L
V
K
W
W
G
E
F
Q
V
S
A
P
P
D
Q
K
G
M
L
--
23
PsiBlast_CBE
67.32
31%
-101
- C5 -
3AQM
1
?
B:
[28-250]
-----------------------------
L
N
K
A
----
G
Y
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
P
---
K
D
F
D
V
T
T
N
A
T
P
E
Q
V
R
K
L
--
F
R
-
N
C
R
L
V
----
G
R
R
F
-------
R
--
L
A
H
V
M
F
-
G
----
P
E
I
I
E
V
A
T
F
R
G-----------------
N
I
FGSI
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
Y
----
S
-
V
-
A
---------
D
F
T
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
L
I
G
N
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
G
--
M
---
R
I
S
P
E
T
A
E
P
I
P
R
L
A
--
T
--
L
L
N
D
I
P
P
A
R
L
F
E
E
S
L
K
L
L
Q
-----------
A
G
---
Y
G
---
Y
E
T
Y
K
L
L
C
E
Y
H
L
F
Q
P
L
-
F
P
-----
T
I
---------
T
R
Y
F
----
T
E
-------
N
G
D
S
----
P
--------
M
----------------------------
E
--
R
I
I
E
Q
V
----------
L
K
N
T
D
-----
T
R
I
H
N
D
M
R
--------------
V
N
P
A
F
L
F
A
A
M
F
W
Y
P
L
L
E
T
A
Q
K
I
A
Q
E
S
G
L
---
T
Y
------
H
----------
D
A
F
A
L
A
M
N
D
V
L
D
E
A
C
R
S
L
A
I
P
-
K
R
L
T
T
L
---
T
R
----
D
--
I
----
W
Q
L
---
Q
L
R
M
S
R
R
Q
-------
G
K
R
A
W
K
L
-
L
E
H
P
K
F
R
A
A
Y
-
D
L
L
A
L
R
A
E
V
E
R
N
A
E
L
Q
R
L
V
K
W
W
G
E
F
Q
V
S
A
P
P
D
Q
K
G
M
L
--
8
PsiBlast_PDB
66.76
31%
-91
- C5 -
3AQK
-
?
A:
[44-266]
-----------------------------
L
N
K
A
----
G
Y
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
P
---
K
D
F
D
V
T
T
N
A
T
P
E
Q
V
R
K
L
--
F
R
-
N
C
R
L
V
----
G
R
R
F
-------
R
--
L
A
H
V
M
F
-
G
----
P
E
I
I
E
V
A
T
F
R
------------------
N
I
FGS
I
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
Y
----
S
-
V
-
A
---------
D
F
T
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
L
I
G
N
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
G
--
M
---
R
I
S
P
E
T
A
E
P
I
P
R
L
A
--
T
--
L
L
N
D
I
P
P
A
H
L
F
E
E
S
L
K
L
L
Q
-----------
A
G
---
Y
G
---
Y
E
T
Y
K
L
L
C
E
Y
H
L
F
Q
P
L
-
F
P
-----
T
I
---------
T
R
Y
F
----
T
E
-------
N
G
D
S
----
P
--------
M
----------------------------
E
--
R
I
I
E
Q
V
----------
L
K
N
T
D
-----
T
R
I
H
N
D
M
R
--------------
V
N
P
A
F
L
F
A
A
M
F
W
Y
P
L
L
E
T
A
Q
K
I
A
Q
E
S
G
L
---
T
Y
------
H
----------
D
A
F
A
L
A
M
N
D
V
L
D
E
A
C
R
S
L
A
I
P
-
K
R
L
T
T
L
---
T
R
----
D
--
I
----
W
Q
L
---
Q
L
R
M
S
R
R
Q
-------
G
K
R
A
W
K
L
-
L
E
H
P
K
F
R
A
A
Y
-
D
L
L
A
L
R
A
E
V
E
R
N
A
E
L
Q
R
L
V
K
W
W
G
E
F
Q
V
S
A
P
P
D
Q
K
G
M
L
N
E
3
PsiBlast_PDB
62.40
35%
-80
- C5 -
1MIV
1
CCA_GEOSE
A:
[11-203]
-------------------------
I
I
Q
Q
L
K
Q
H
----
G
Y
D
A
Y
F
V
G
G
A
V
R
D
L
L
L
G
R
P
I
---
G
D
V
D
I
A
T
S
A
L
P
E
D
V
M
A
I
F
P
-----
K
T
I
-
D
V
-
G
S
K
H
-------
G
--
T
V
V
V
V
H
-
K
----
G
K
A
Y
E
V
T
T
F
K
-
T
D
G
--------
S
V
T
F
V
R
S
L
----
E
E
D
L
K
R
R
D
F
T
M
N
A
I
A
M
----
D
-
E
-
Y
---------
G
T
-
I
I
D
P
F
G
G
R
E
A
I
R
R
R
I
I
R
T
V
G
E
A
E
K
R
F
R
E
D
A
L
R
M
M
R
A
V
R
F
V
S
E
L
G
--
F
--
A
L
A
P
D
T
E
Q
A
I
V
-
Q
N
A
--
P
--
L
L
A
H
I
S
V
E
R
M
T
M
E
M
E
K
L
L
G
-----------
G
P
---
F
A
---
A
R
A
L
P
L
L
A
E
T
G
L
N
A
Y
L
-
P
G
-----
L
A
---------
G
K
E
K
----
Q
L
-------
R
L
A
A
----
A
--------
Y
----------------------------
R
--
W
P
W
L
A
A
----------
R
E
E
R
W
-----
A
L
L
C
H
A
L
G
--------------
V
Q
E
S
R
P
F
L
R
A
W
K
L
P
N
K
V
V
D
E
A
G
A
I
L
T
A
L
---
A
D
------
I
----------
P
R
P
E
A
W
T
N
E
Q
L
F
S
A
G
L
E
R
A
L
S
-
V
E
T
V
R
A
---
A
F
----
T
--
G
----
A
P
P
---
G
P
W
H
E
K
L
R
-------
R
R
F
A
S
L
P
-
I
K
T
K
G
E
L
A
V
N
-
G
K
D
V
I
E
W
V
G
K
P
A
G
P
W
V
K
E
A
L
D
A
I
W
R
A
V
V
N
G
E
V
E
N
E
K
E
R
I
4
PsiBlast_PDB
62.23
35%
-79
- C5 -
1MIW
2
CCA_GEOSE
A:
[11-203]
-------------------------
I
I
Q
Q
L
K
Q
H
----
G
Y
D
A
Y
F
V
G
G
A
V
R
D
L
L
L
G
R
P
I
---
G
D
V
D
I
A
T
S
A
L
P
E
D
V
M
A
I
F
P
-----
K
T
I
-
D
V
-
G
S
K
H
-------
G
--
T
V
V
V
V
H
-
K
----
G
K
A
Y
E
V
T
T
F
K
-
T
D
G
--------
S
V
T
F
V
R
S
L
----
E
E
D
L
K
R
R
D
F
T
M
N
A
I
A
M
----
D
-
E
-
Y
---------
G
T
-
I
I
D
P
F
G
G
R
E
A
I
R
R
R
I
I
R
T
V
G
E
A
E
K
R
F
R
E
D
A
L
R
M
M
R
A
V
R
F
V
S
E
L
G
--
F
--
A
L
A
P
D
T
E
Q
A
I
V
-
Q
N
A
--
P
--
L
L
A
H
I
S
V
E
R
M
T
M
E
M
E
K
L
L
G
-----------
G
P
---
F
A
---
A
R
A
L
P
L
L
A
E
T
G
L
N
A
Y
L
-
P
G
-----
L
A
---------
G
K
E
K
----
Q
L
-------
R
L
A
A
----
A
--------
Y
----------------------------
R
--
W
P
W
L
A
A
----------
R
E
E
R
W
-----
A
L
L
C
H
A
L
G
--------------
V
Q
E
S
R
P
F
L
R
A
W
K
L
P
N
K
V
V
D
E
A
G
A
I
L
T
A
L
---
A
D
------
I
----------
P
R
P
E
A
W
T
N
E
Q
L
F
S
A
G
L
E
R
A
L
S
-
V
E
T
V
R
A
---
A
F
----
T
--
G
----
A
P
P
---
G
P
W
H
E
K
L
R
-------
R
R
F
A
S
L
P
-
I
K
T
K
G
E
L
A
V
N
-
G
K
D
V
I
E
W
V
G
K
P
A
G
P
W
V
K
E
A
L
D
A
I
W
R
A
V
V
N
G
E
V
E
N
E
K
E
R
I
53
Fugue
62.03
18%
-52
- C5 -
1VFG
1
?
A:
[1-351]
------------------------
M
V
G
Q
I
A
K
E
M
----
G
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
V
---
W
D
V
D
F
V
V
E
G
N
A
I
E
L
A
K
E
L
A
R
R
-
H
G
V
N
V
-
H
P
-
F
P
E
F
-------
G
--
T
A
H
L
K
I
-
G
----
K
L
K
L
E
F
A
T
A
R
-
R
E
T
V
E
P
A
----------
S
L
----
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
I
S
VNL
E
-
D
-
Y
---------
G
T
-
L
I
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
V
L
H
--
P
V
S
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
L
N
--
F
---
K
L
S
R
S
T
E
K
L
L
K
Q
A
V
--
N
L
G
L
L
K
E
A
P
R
G
R
L
I
N
E
I
K
L
A
L
R
-----------
E
D
---
R
F
---
L
E
I
L
E
L
Y
R
K
Y
R
V
L
E
E
I
-
I
E
-----
G
F
---------
Q
W
N
E
----
K
V
-------
L
Q
K
L
----
Y
--------
A
----------------------------
L
--
R
K
V
V
D
W
----------
H
A
L
E
F
-----
S
E
E
R
I
D
Y
G
--------------
W
L
Y
L
L
I
L
I
S
N
L
D
Y
E
R
G
K
H
F
L
E
E
M
S
A
P
S
W
---
V
R
------
E
----------
T
Y
K
F
M
K
F
K
L
G
S
L
K
E
E
L
K
--------------------------------------
K
A
K
E
-------
N
Y
E
V
Y
R
L
-
L
K
P
L
H
T
S
V
L
L
-
L
L
M
L
E
E
E
L
K
E
K
I
K
L
Y
L
E
K
L
R
K
V
K
L
P
--------------
22
PsiBlast_CBE
61.52
35%
-76
- C5 -
1MIY
3
CCA_GEOSE
B:
[11-203]
-------------------------
I
I
Q
Q
L
K
Q
H
----
G
Y
D
A
Y
F
V
G
G
A
V
R
D
L
L
L
G
R
P
I
---
G
D
V
D
I
A
T
S
A
L
P
E
D
V
M
A
I
F
P
-----
K
T
I
-
D
V
-
G
S
K
H
-------
G
--
T
V
V
V
V
H
-
K
----
G
K
A
Y
E
V
T
T
F
K
-
T
D
G
--------
S
V
T
F
V
R
S
L
----
E
E
D
L
K
R
R
D
F
T
M
N
A
I
A
M
----
D
-
E
-
Y
---------
G
T
-
I
I
D
P
F
G
G
R
E
A
I
R
R
R
I
I
R
T
V
G
E
A
E
K
R
F
R
E
D
A
L
R
M
M
R
A
V
R
F
V
S
E
L
G
--
F
--
A
L
A
P
D
T
E
Q
A
I
V
-
Q
N
A
--
P
--
L
L
A
H
I
S
V
E
R
M
T
M
E
M
E
K
L
L
G
-----------
G
P
---
F
A
---
A
R
A
L
P
L
L
A
E
T
G
L
N
A
Y
L
-
P
G
-----
L
A
---------
G
K
E
K
----
Q
L
-------
R
L
A
A
----
A
--------
Y
----------------------------
R
--
W
P
W
L
A
A
----------
R
E
E
R
W
-----
A
L
L
C
H
A
L
G
--------------
V
Q
E
S
R
P
F
L
R
A
W
K
L
P
N
K
V
V
D
E
A
G
A
I
L
T
A
L
---
A
D
------
I
----------
P
R
P
E
A
W
T
N
E
Q
L
F
S
A
G
L
E
R
A
L
S
-
V
E
T
V
R
A
---
A
F
----
T
--
G
----
A
P
P
---
G
P
W
H
E
K
L
R
-------
R
R
F
A
S
L
P
-
I
K
T
K
G
E
L
A
V
N
-
G
K
D
V
I
E
W
V
G
K
P
A
G
P
W
V
K
E
A
L
D
A
I
W
R
A
V
V
N
G
E
V
E
N
E
K
E
R
I