@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0169: (2015-11-29 )
MKEAKFIFVTGGVVSSLGKGLVASSVGALLQAHGFKVRIRKLDPYLNIDPGTMSPTQHGEVFVTEDGAETDLDLGHYERFTGIKATKDDNITTGKMYHELLKKERRGDYLGKTVQVIPHVTDLIKSFIFNGTEGLDFVICEIGGTVGDIESQPFLEAIRQISYKLGKQRVILIHLTLVPYLAVAQELKTKPTQHSVRELNFVGLQPDIILCRSEKEISDNQRGKIANLCNVSLSNVISAPDVSHIYELPVLYNQCGLGTQVLEHFHLSKPKPSLVGWNQIVHSMRHPMQEVTVSIVGKYTEFPDTYKSLVEALSHSAISNRIEVKINWVNSREKSGKPINEKFMGDKLKNSHAILVPGGFGDDGIEGKMLAISYARTNNIPFFGICLGMQLAVIEFARNVIKFKDVHSEEFYTCKHPIIKLAGDKNVDLGGTMRLGAYKCNISPNSKMAGAYSDTIISERHRHRYIINLDYKDDLEKNGLICSGMSEDGTYIEAVELENHPWFIGVQFHPEFQSKPFSPHPLFVSFIKAVVNKVKKTEG
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130------..--.--.------.....140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280...--.--...290.......300.......310.......320.......330.-----......---340.........350.......360.......370.......380.......390.......400.......410.-.-..-....420..----------.--..-..430.......-440-.......450..-.-....460.......470.......480.......490.....--..500.......510.......520.......530.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKEA
K
F
I
F
VT
G
G
V
V
S
S
L
G
K
G
L
V
A
S
S
V
G
A
L
L
Q
AHG
F
K
V
R
I
R
KLD
P
Y
L
NIDPGTMSPTQHG
E
V
F
V
TEDGAETDLDLG
H
Y
E
R
FTGIKATKDDNIT
T
G
K
M
Y
H
E
L
L
K
K
ERRGDYLG
K
T
V
Q
V
I
P
H
V
T
D
L
I
K
S
F
IFN--------GT--E--G------
L
D
F
V
I
C
EIGGTVGDIES
Q
P
F
L
E
A
I
R
Q
I
S
Y
KLGK
Q
R
V
I
L
I
H
L
T
L
V
P
Y
L
A
V
A
Q
E
LKTKPTQHS
V
R
E
L
N
F
VGLQP
D
I
I
L
CRSEKEISDNQRGK
I
A
N
L
CN
V
S
L
S
NVISAP
D
V
S
H
I
Y
EL
P
V
L
Y
NQCG
L
G
T
Q
V
L
E
H
FHLSKPKPSLV
G
W
N
Q
I
V
H
S
M
R--H--
P
M
Q
E
V
T
V
S
I
V
GKYTEF
P
D
T
Y
K
S
L
V
E
A
L
S
H
S
A
IS
N
R
I
E
V
K
I
N
W
VNSRE-----KSGKPI---
N
--
E
K
F
M
GDKLKNS
H
A
I
L
V
PGGFGDDGIEG
K
M
L
A
I
S
Y
ARTNNIP
F
F
G
I
C
L
G
M
Q
L
A
V
I
E
F
A
R
N
V
I
K
F
KDVHSEEF-Y-T-CK-H
P
I
I
K
LAGD----------K--NV-DLGG
T
M
R
L
G
A
Y
K
-
C
NI-SPNSKMAGAY
S
D
-
T
-
I
I
S
ERHR
H
R
Y
I
I
NLDYKDDLEKN
G
L
I
CSGMSEDG
T
Y
I
E
A
V
EL--ENH
P
W
F
I
G
V
Q
FHPEFQSKPFSP
H
P
L
F
V
S
F
I
K
A
V
V
N
K
V
KKTEG
64
Fugue
92.62
51%
-85
- C5 -
1S1M
14
PYRG_ECOLI
A:
[1-544]
-
M
T
T
N
Y
I
F
V
T
G
G
V
V
S
S
L
G
K
G
I
A
A
A
S
L
A
A
I
L
E
A
R
G
L
N
V
T
I
M
K
L
D
P
Y
I
N
V
D
P
G
T
M
S
P
I
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
L
G
H
Y
E
R
F
I
R
T
K
M
S
R
R
N
N
F
T
T
G
R
I
Y
S
D
V
L
R
K
E
R
R
G
D
Y
L
G
A
T
V
Q
V
I
P
H
I
T
N
A
I
K
E
R
V
L
E
--------
G
G
--
E
--
G
------
H
D
V
V
L
V
E
I
G
G
T
V
G
D
I
E
S
L
P
F
L
E
A
I
R
Q
M
A
V
E
I
G
R
E
H
T
L
F
M
H
L
T
L
V
P
Y
M
A
A
S
G
E
V
K
T
K
P
T
Q
H
S
V
K
E
L
L
S
I
G
I
Q
P
D
I
L
I
C
R
S
D
R
A
V
P
A
N
E
R
A
K
I
A
L
F
C
N
V
P
E
K
A
V
I
S
L
K
D
V
D
S
I
Y
K
I
P
G
L
L
K
S
Q
G
L
D
D
Y
I
C
K
R
F
S
L
N
C
P
E
A
N
L
S
E
W
E
Q
V
I
F
E
E
A
--
N
--
P
V
S
E
V
T
I
G
M
V
G
K
Y
I
E
L
P
D
A
Y
K
S
V
I
E
A
L
K
H
G
G
L
K
N
R
V
S
V
N
I
K
L
I
D
S
Q
D
-----
V
E
T
R
G
V
---
E
--------
I
L
K
G
L
D
A
I
L
V
P
G
G
F
G
Y
R
G
V
E
G
M
I
T
T
A
R
F
A
R
E
N
N
I
P
Y
L
G
I
C
L
G
M
Q
V
A
L
I
D
Y
A
R
H
V
A
N
M
E
N
A
N
S
T
E
F
-
V
-
P
D
C
K
-
Y
P
V
V
A
L
I
T
E
----------
W
RD
E
N
-
G
N
V
E
T
M
R
L
G
A
Q
Q
-
C
Q
L
-
V
D
D
S
L
V
R
Q
L
Y
N
A
-
P
-
T
I
V
E
R
H
R
H
R
Y
E
V
N
N
M
L
L
K
Q
I
E
D
A
G
L
R
V
A
G
R
S
G
D
D
Q
L
V
E
I
I
E
V
--
P
N
H
P
W
F
V
A
C
Q
F
H
P
E
F
T
S
T
P
R
D
G
H
P
L
F
A
G
F
V
K
A
A
S
E
F
Q
K
R
Q
A
-
21
PsiBlast_CBE
92.15
51%
-96
- C5 -
2AD5
5
PYRG_ECOLI
B:
[5-535]
-----
Y
I
F
V
T
G
G
V
V
S
S
L
G
K
G
I
A
A
A
S
L
A
A
I
L
E
A
R
G
L
N
V
T
I
M
K
L
D
P
Y
I
N
V
D
P
G
T
M
S
P
I
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
L
G
H
Y
E
R
F
I
R
T
K
M
S
R
R
N
N
F
T
T
G
R
I
Y
S
D
V
L
R
K
E
R
R
G
D
Y
L
G
A
T
V
Q
V
I
P
H
I
T
N
A
I
K
E
R
V
L
E
--------
G
G
--
E
--
G
------
H
D
V
V
L
V
E
I
G
G
T
V
G
D
I
E
S
L
P
F
L
E
A
I
R
Q
M
A
V
E
I
G
R
E
H
T
L
F
M
H
L
T
L
V
P
Y
M
A
A
S
G
E
V
K
T
K
P
T
Q
H
S
V
K
E
L
L
S
I
G
I
Q
P
D
I
L
I
C
R
S
D
R
A
V
P
A
N
E
R
A
K
I
A
L
F
C
N
V
P
E
K
A
V
I
S
L
K
D
V
D
S
I
Y
K
I
P
G
L
L
K
S
Q
G
L
D
D
Y
I
C
K
R
F
S
L
N
C
P
E
A
N
L
S
E
W
E
Q
V
I
F
E
E
A
--
N
--
P
V
S
E
V
T
I
G
M
V
G
K
Y
I
E
L
P
D
A
Y
K
S
V
I
E
A
L
K
H
G
G
L
K
N
R
V
S
V
N
I
K
L
I
D
S
Q
D
-----
V
E
T
R
G
V
-----------
E
I
L
K
G
L
D
A
I
L
V
P
G
G
F
G
Y
R
G
V
E
G
M
I
T
T
A
R
F
A
R
E
N
N
I
P
Y
L
G
I
C
L
G
M
Q
V
A
L
I
D
Y
A
R
H
V
A
N
M
E
N
A
N
S
T
E
F
-
V
P
D
-
C
K
-
Y
P
V
V
A
L
I
T
E
WRDENGNVEV----------
T
M
R
L
G
A
Q
Q
-
C
Q
L
-
V
D
D
S
L
V
R
Q
L
Y
N
A
-
P
-
T
I
V
E
R
H
R
H
R
Y
E
V
N
N
M
L
L
K
Q
I
E
D
A
G
L
R
V
A
G
R
S
G
D
D
Q
L
V
E
I
I
E
V
--
P
N
H
P
W
F
V
A
C
Q
F
H
P
E
F
T
S
T
P
R
D
G
H
P
L
F
A
G
F
V
K
A
A
S
E
F
Q
K
R
Q
A
K
22
PsiBlast_CBE
91.79
51%
-92
- C5 -
1S1M
16
PYRG_ECOLI
B:
[5-535]
-----
Y
I
F
V
T
G
G
V
V
S
S
L
G
K
G
I
A
A
A
S
L
A
A
I
L
E
A
R
G
L
N
V
T
I
M
K
L
D
P
Y
I
N
V
D
P
G
T
M
S
P
I
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
L
G
H
Y
E
R
F
I
R
T
K
M
S
R
R
N
N
F
T
T
G
R
I
Y
S
D
V
L
R
K
E
R
R
G
D
Y
L
G
A
T
V
Q
V
I
P
H
I
T
N
A
I
K
E
R
V
L
E
--------
G
G
--
E
--
G
------
H
D
V
V
L
V
E
I
G
G
T
V
G
D
I
E
S
L
P
F
L
E
A
I
R
Q
M
A
V
E
I
G
R
E
H
T
L
F
M
H
L
T
L
V
P
Y
M
A
A
S
G
E
V
K
T
K
P
T
Q
H
S
V
K
E
L
L
S
I
G
I
Q
P
D
I
L
I
C
R
S
D
R
A
V
P
A
N
E
R
A
K
I
A
L
F
C
N
V
P
E
K
A
V
I
S
L
K
D
V
D
S
I
Y
K
I
P
G
L
L
K
S
Q
G
L
D
D
Y
I
C
K
R
F
S
L
N
C
P
E
A
N
L
S
E
W
E
Q
V
I
F
E
E
A
--
N
--
P
V
S
E
V
T
I
G
M
V
G
K
Y
I
E
L
P
D
A
Y
K
S
V
I
E
A
L
K
H
G
G
L
K
N
R
V
S
V
N
I
K
L
I
D
S
Q
D
-----
V
E
T
R
G
V
-----------
E
I
L
K
G
L
D
A
I
L
V
P
G
G
F
G
Y
R
G
V
E
G
M
I
T
T
A
R
F
A
R
E
N
N
I
P
Y
L
G
I
C
L
G
M
Q
V
A
L
I
D
Y
A
R
H
V
A
N
M
E
N
A
N
S
T
E
F
-
V
P
D
-
C
K
-
Y
P
V
V
A
L
I
T
E
WRDENGNVEV----------
T
M
R
L
G
A
Q
Q
-
C
Q
L
-
V
D
D
S
L
V
R
Q
L
Y
N
A
-
P
-
T
I
V
E
R
H
R
H
R
Y
E
V
N
N
M
L
L
K
Q
I
E
D
A
G
L
R
V
A
G
R
S
G
D
D
Q
L
V
E
I
I
E
V
--
P
N
H
P
W
F
V
A
C
Q
F
H
P
E
F
T
S
T
P
R
D
G
H
P
L
F
A
G
F
V
K
A
A
S
E
F
Q
K
R
Q
A
K
4
PsiBlast_PDB
90.70
45%
-94
- C5 -
3NVA
-
PYRG_SULSO
A:
[4-534]
----
K
Y
I
V
V
T
G
G
V
L
S
S
V
G
K
G
T
L
V
A
S
I
G
M
L
L
K
R
R
G
Y
N
V
T
A
V
K
I
D
P
Y
I
N
V
D
A
G
T
M
N
P
Y
M
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
L
G
H
Y
E
R
F
M
D
V
N
M
T
K
Y
N
N
I
T
A
G
K
V
Y
F
E
V
I
K
K
E
R
E
G
K
Y
L
G
Q
T
V
Q
I
I
P
H
V
T
D
Q
I
K
D
M
I
R
Y
--------
A
S
--
K
I
N
N
------
A
E
I
T
L
V
E
I
G
G
T
V
G
D
I
E
S
L
P
F
L
E
A
V
R
Q
L
K
L
E
E
G
E
D
N
V
I
F
V
H
I
A
L
V
E
Y
L
S
V
T
G
E
L
K
T
K
P
L
Q
H
S
V
Q
E
L
R
R
I
G
I
Q
P
D
F
I
V
G
R
A
T
L
P
L
D
D
E
T
R
R
K
I
A
L
F
T
N
V
K
V
D
H
I
V
S
S
Y
D
V
E
T
S
Y
E
V
P
I
I
L
E
S
Q
K
L
V
S
K
I
L
S
R
L
K
L
E
D
R
Q
V
D
L
T
D
W
I
S
F
V
N
N
I
K
GI
N
--
S
K
K
T
I
N
I
A
L
V
G
K
Y
T
K
L
K
D
S
Y
I
S
I
K
E
A
I
Y
H
A
S
A
Y
I
G
V
R
P
K
L
I
W
I
E
S
T
D
-----
L
E
S
------
D
--
T
K
N
L
N
E
I
L
G
N
V
N
G
I
I
V
L
P
G
F
G
S
R
G
A
E
G
K
I
K
A
I
K
Y
A
R
E
H
N
I
P
F
L
G
I
C
F
G
F
Q
L
S
I
V
E
F
A
R
D
V
L
G
L
S
E
A
N
S
T
E
I
-
N
P
N
-
T
K
-
D
P
V
I
T
L
L
D
E
Q---------
K
--
N
V
T
Q
L
G
G
T
M
R
L
G
A
Q
K
-
I
I
L
-
K
E
G
T
I
A
Y
Q
L
Y
G
K
-
K
-
V
V
Y
E
R
H
R
H
R
Y
E
V
N
P
K
Y
V
D
I
L
E
D
A
G
L
V
V
S
G
I
S
E
N
G
-
L
V
E
I
I
E
L
--
P
S
N
K
F
F
V
A
T
Q
A
H
P
E
F
K
S
R
P
T
N
P
S
P
I
Y
L
G
F
I
R
A
V
A
S
-------
33
HHSearch
90.55
46%
-92
- C5 -
3NVA
-
PYRG_SULSO
A:
[2-534]
--
P
N
K
Y
I
V
V
T
G
G
V
L
S
S
V
G
K
G
T
L
V
A
S
I
G
M
L
L
K
R
R
G
Y
N
V
T
A
V
K
I
D
P
Y
I
N
V
D
A
G
T
M
N
P
Y
M
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
L
G
H
Y
E
R
F
M
D
V
N
M
T
K
Y
N
N
I
T
A
G
K
V
Y
F
E
V
I
K
K
E
R
E
G
K
Y
L
G
Q
T
V
Q
I
I
P
H
V
T
D
Q
I
K
D
M
I
R
Y
--------
A
S
K
I
N
--
N
------
A
E
I
T
L
V
E
I
G
G
T
V
G
D
I
E
S
L
P
F
L
E
A
V
R
Q
L
K
L
E
E
G
E
D
N
V
I
F
V
H
I
A
L
V
E
Y
L
S
V
T
G
E
L
K
T
K
P
L
Q
H
S
V
Q
E
L
R
R
I
G
I
Q
P
D
F
I
V
G
R
A
T
L
P
L
D
D
E
T
R
R
K
I
A
L
F
T
N
V
K
V
D
H
I
V
S
S
Y
D
V
E
T
S
Y
E
V
P
I
I
L
E
S
Q
K
L
V
S
K
I
L
S
R
L
K
L
E
D
R
Q
V
D
L
T
D
W
I
S
F
V
N
N
I
K
--
G
IN
S
K
K
T
I
N
I
A
L
V
G
K
Y
T
K
L
K
D
S
Y
I
S
I
K
E
A
I
Y
H
A
S
A
Y
I
G
V
R
P
K
L
I
W
I
E
S
T
D
-----
L
E
S
D
T
--------
K
N
L
N
E
I
L
G
N
V
N
G
I
I
V
L
P
G
F
G
S
R
G
A
E
G
K
I
K
A
I
K
Y
A
R
E
H
N
I
P
F
L
G
I
C
F
G
F
Q
L
S
I
V
E
F
A
R
D
V
L
G
L
S
E
A
N
S
T
E
I
-
N
-
P
-
N
T
K
D
P
V
I
T
L
L
D
E
----------
Q
KN
V
T
-
Q
L
G
G
T
M
R
L
G
A
Q
K
-
I
I
L
-
K
E
G
T
I
A
Y
Q
L
Y
G
K
-
K
-
V
V
Y
E
R
H
R
H
R
Y
E
V
N
P
K
Y
V
D
I
L
E
D
A
G
L
V
V
S
G
I
S
E
N
-
G
L
V
E
I
I
E
L
--
P
S
N
K
F
F
V
A
T
Q
A
H
P
E
F
K
S
R
P
T
N
P
S
P
I
Y
L
G
F
I
R
A
V
A
S
-------
24
PsiBlast_CBE
89.38
47%
-91
- C5 -
4ZDI
1
PYRG_MYCTU
G:
[11-548]
----
K
H
L
F
V
S
G
---
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
--------
M
A
--
Q
--
P
DADGNR
P
D
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
R
D
V
D
W
T
E
W
D
D
L
L
R
R
V
H
--
E
--
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
A
S
D
G
-----
C
E
T
T
S
G
---
A
--
A
A
A
L
G
D
----
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
-
D
-
T
P
-
D
P
V
I
A
T
M
----------------------
T
M
R
L
G
S
Y
P
-
A
V
L
-
E
P
D
S
V
V
A
Q
A
Y
Q
T
-
T
-
Q
V
S
E
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
T
S
P
D
G
H
L
V
E
F
V
E
Y
PP
D
R
H
P
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
D
Y
K
A
G
---
25
PsiBlast_CBE
89.32
47%
-93
- C5 -
4ZDI
1
PYRG_MYCTU
F:
[11-548]
----
K
H
L
F
V
S
G
-----
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
--------
M
A
--
Q
--
P
DADGNR
P
D
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
R
D
V
D
W
T
E
W
D
D
L
L
R
R
V
H
--
E
--
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
A
S
D
G
-----
C
E
T
T
S
G
---
A
--
A
A
A
L
G
D
----
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
-
D
-
T
P
-
D
P
V
I
A
T
M
----------------------
T
M
R
L
G
S
Y
P
-
A
V
L
-
E
P
D
S
V
V
A
Q
A
Y
Q
T
-
T
-
Q
V
S
E
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
T
S
P
D
G
H
L
V
E
F
V
E
Y
PP
D
R
H
P
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
D
Y
K
A
G
---
23
PsiBlast_CBE
88.83
47%
-92
- C5 -
4ZDI
1
PYRG_MYCTU
H:
[11-548]
----
K
H
L
F
V
S
G
G
-----
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
--------
M
A
--
Q
--
P
DADGNR
P
D
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
R
D
V
D
W
T
E
W
D
D
L
L
R
R
V
H
--
E
--
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
A
S
D
G
-----
C
E
T
T
S
G
---
A
--
A
A
A
L
G
D
----
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
-
D
-
T
P
-
D
P
V
I
A
T
M
----------------------
T
M
R
L
G
S
Y
P
-
A
V
L
-
E
P
D
S
V
V
A
Q
A
Y
Q
T
-
T
-
Q
V
S
E
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
T
S
P
D
G
H
L
V
E
F
V
E
Y
PP
D
R
H
P
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
D
Y
K
A
G
---
2
PsiBlast_PDB
88.64
47%
-92
- C5 -
4ZDJ
4
PYRG_MYCTU
A:
[11-548]
----
K
H
L
F
V
S
G
G
V
A
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
--------
M
A
--
Q
--
P
DADGNR
P
D
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
R
D
V
D
W
T
E
W
D
D
L
L
R
R
V
H
--
E
--
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
A
S
D
G
-----
C
E
T
T
S
G
---
A
--
A
A
A
L
G
D
----
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
-
D
-
T
P
-
D
P
V
I
A
T
M
--------------------
G
G
T
M
R
L
G
S
Y
P
-
A
V
L
-
E
P
D
S
V
V
A
Q
A
Y
Q
T
-
T
-
Q
V
S
E
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
T
S
P
D
G
H
L
V
E
F
V
E
Y
PP
D
R
H
P
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
D
Y
K
A
G
E
--
27
PsiBlast_CBE
88.51
47%
-92
- C5 -
4ZDI
1
PYRG_MYCTU
D:
[11-548]
----
K
H
L
F
V
S
G
G
V
A
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
--------
M
A
--
Q
--
P
DADGNR
P
D
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
R
D
V
D
W
T
E
W
D
D
L
L
R
R
V
H
--
E
--
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
A
S
D
G
-----
C
E
T
T
S
G
---
A
--
A
A
A
L
G
D
----
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
-
D
-
T
P
-
D
P
V
I
A
T
M
----------------------
T
M
R
L
G
S
Y
P
-
A
V
L
-
E
P
D
S
V
V
A
Q
A
Y
Q
T
-
T
-
Q
V
S
E
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
T
S
P
D
G
H
L
V
E
F
V
E
Y
PP
D
R
H
P
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
D
Y
K
A
G
E
--
29
PsiBlast_CBE
88.46
47%
-92
- C5 -
4ZDI
1
PYRG_MYCTU
B:
[11-548]
----
K
H
L
F
V
S
G
G
V
A
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
--------
M
A
--
Q
--
P
DADGNR
P
D
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
R
D
V
D
W
T
E
W
D
D
L
L
R
R
V
H
--
E
--
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
A
S
D
G
-----
C
E
T
T
S
G
---
A
--
A
A
A
L
G
D
----
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
-
D
-
T
P
-
D
P
V
I
A
T
M
--------------------
G
G
T
M
R
L
G
S
Y
P
-
A
V
L
-
E
P
D
S
V
V
A
Q
A
Y
Q
T
-
T
-
Q
V
S
E
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
T
S
P
D
G
H
L
V
E
F
V
E
Y
P
P
D
R
H
P
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
D
Y
K
A
G
E
L
-
26
PsiBlast_CBE
88.45
47%
-91
- C5 -
4ZDI
1
PYRG_MYCTU
E:
[11-548]
----
K
H
L
F
V
S
G
G
V
A
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
--------
M
A
--
Q
--
P
DADGNR
P
D
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
R
D
V
D
W
T
E
W
D
D
L
L
R
R
V
H
--
E
--
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
A
S
D
G
-----
C
E
T
T
S
G
---
A
--
A
A
A
L
G
D
----
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
-
D
-
T
P
-
D
P
V
I
A
T
M
----------------------
T
M
R
L
G
S
Y
P
-
A
V
L
-
E
P
D
S
V
V
A
Q
A
Y
Q
T
-
T
-
Q
V
S
E
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
T
S
P
D
G
H
L
V
E
F
V
E
Y
PP
D
R
H
P
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
D
Y
K
A
G
---
3
PsiBlast_PDB
88.36
47%
-92
- C5 -
4ZDK
4
PYRG_MYCTU
A:
[10-547]
----
K
H
L
F
V
S
G
G
V
A
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
--------
M
A
--
Q
--
P
DADGNR
P
D
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
R
D
V
D
W
T
E
W
D
D
L
L
R
R
V
H
--
E
--
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
A
S
D
G
-----
C
E
T
T
S
G
---
A
--
A
A
A
L
G
D
----
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
-
D
-
T
P
-
D
P
V
I
A
T
M
--------------------
G
G
T
M
R
L
G
S
Y
P
-
A
V
L
-
E
P
D
S
V
V
A
Q
A
Y
Q
T
-
T
-
Q
V
S
E
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
T
S
P
D
G
H
L
V
E
F
V
E
Y
PP
D
R
H
P
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
D
Y
K
A
G
E
L
-
1
PsiBlast_PDB
88.19
47%
-92
- C5 -
4ZDI
1
PYRG_MYCTU
A:
[11-548]
----
K
H
L
F
V
S
G
G
V
A
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
--------
M
A
--
Q
--
P
DADGNR
P
D
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
R
D
V
D
W
T
E
W
D
D
L
L
R
R
V
H
--
E
--
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
A
S
D
G
-----
C
E
T
T
S
G
---
A
--
A
A
A
L
G
D
----
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
-
D
-
T
P
-
D
P
V
I
A
T
M
---------------------
G
T
M
R
L
G
S
Y
P
-
A
V
L
-
E
P
D
S
V
V
A
Q
A
Y
Q
T
-
T
-
Q
V
S
E
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
T
S
P
D
G
H
L
V
E
F
V
E
Y
P
P
D
R
H
P
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
D
Y
K
A
G
---
28
PsiBlast_CBE
88.18
47%
-91
- C5 -
4ZDI
1
PYRG_MYCTU
C:
[11-548]
----
K
H
L
F
V
S
G
G
V
A
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
--------
M
A
--
Q
--
P
DADGNR
P
D
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
R
D
V
D
W
T
E
W
D
D
L
L
R
R
V
H
--
E
--
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
A
S
D
G
-----
C
E
T
T
S
G
---
A
--
A
A
A
L
G
D
----
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
-
D
-
T
P
-
D
P
V
I
A
T
M
---------------------
G
T
M
R
L
G
S
Y
P
-
A
V
L
-
E
P
D
S
V
V
A
Q
A
Y
Q
T
-
T
-
Q
V
S
E
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
T
S
P
D
G
H
L
V
E
F
V
E
Y
PP
D
R
H
P
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
D
Y
K
A
G
E
L
-
30
PsiBlast_CBE
87.94
47%
-93
- C5 -
4ZDK
4
PYRG_MYCTU
B:
[10-547]
----
K
H
L
F
V
S
G
G
V
A
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
--------
M
A
--
Q
--
P
DADGNR
P
D
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
R
D
V
D
W
T
E
W
D
D
L
L
R
R
V
H
--
E
--
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
A
S
D
G
-----
C
E
T
T
S
G
---
A
--
A
A
A
L
G
D
----
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
-
D
-
T
P
-
D
P
V
I
A
T
M
--------------------
G
G
T
M
R
L
G
S
Y
P
-
A
V
L
-
E
P
D
S
V
V
A
Q
A
Y
Q
T
-
T
-
Q
V
S
E
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
T
S
P
D
G
H
L
V
E
F
V
E
Y
PP
D
R
H
P
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
D
Y
K
A
G
E
L
-
5
PsiBlast_PDB
64.50
41%
-103
- C5 -
2VKT
-
PYRG2_HUMAN
A:
[296-551]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
I
C
S
I
A
L
V
G
K
Y
-
K
L
R
D
C
Y
A
S
V
F
K
A
L
E
H
S
A
L
A
I
N
H
K
L
N
L
M
Y
I
D
S
I
D
LE
K
I
T
E
T
E
D
P
V
---
K
--
F
H
E
A
W
Q
K
L
C
K
A
D
G
I
L
V
P
G
G
F
G
I
R
G
T
L
G
K
L
Q
A
I
S
W
A
R
T
K
K
I
P
F
L
G
V
C
L
G
M
Q
L
A
V
I
E
F
A
R
N
C
L
N
L
K
D
A
D
S
T
E
F
-
R
P
N
-
A
P
-
V
P
L
V
I
D
M
P
E
----------
H
---------
T
M
R
L
G
I
R
R
-
T
V
F
K
T
E
N
S
I
L
R
K
L
Y
G
D
-
V
P
F
I
E
E
R
H
R
H
R
F
E
V
N
P
N
L
I
K
Q
F
E
Q
N
D
L
S
F
V
G
Q
D
V
D
G
D
R
M
E
I
I
E
L
--
A
N
H
P
Y
F
V
G
V
Q
F
H
P
E
F
S
S
R
P
M
K
P
S
P
P
Y
L
G
L
L
L
A
A
T
G
N
L
-----
6
PsiBlast_PDB
63.09
41%
-93
- C5 -
2V4U
-
PYRG2_HUMAN
A:
[296-551]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
I
C
S
I
A
L
V
G
K
Y
T
K
L
R
D
C
Y
A
S
V
F
K
A
L
E
H
S
A
L
A
I
N
H
K
L
N
L
M
Y
I
D
S
I
D
LE
K
I
T
E
T
E
D
P
V
---
K
--
F
H
E
A
W
Q
K
L
C
K
A
D
G
I
L
V
P
G
G
F
G
I
R
G
T
L
G
K
L
Q
A
I
S
W
A
R
T
K
K
I
P
F
L
G
V
-
L
G
M
Q
L
A
V
I
E
F
A
R
N
C
L
N
L
K
D
A
D
S
T
E
F
-
R
P
N
-
A
P
-
V
P
L
V
I
D
M
P
E
----------
H
--
N
P
G
N
L
G
G
T
M
R
L
G
I
R
R
-
T
V
F
K
T
E
N
S
I
L
R
K
L
Y
G
D
-
V
P
F
I
E
E
R
H
R
H
R
F
E
V
N
P
N
L
I
K
Q
F
E
Q
N
D
L
S
F
V
G
Q
D
V
D
G
D
R
M
E
I
I
E
L
--
A
N
H
P
Y
F
V
G
V
Q
F
H
P
E
F
S
S
R
P
M
K
P
S
P
P
Y
L
G
L
L
L
A
A
T
G
N
L
-----
38
HHSearch
60.45
41%
-81
- C5 -
2V4U
-
PYRG2_HUMAN
A:
[296-554]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
I
C
S
I
A
L
V
G
K
Y
T
K
L
R
D
C
Y
A
S
V
F
K
A
L
E
H
S
A
L
A
I
N
H
K
L
N
L
M
Y
I
D
S
I
D
-----
L
E
K
I
T
E
T
E
D
P
V
K
F
H
E
A
W
Q
K
L
C
K
A
D
G
I
L
V
P
G
G
F
G
I
R
G
T
L
G
K
L
Q
A
I
S
W
A
R
T
K
K
I
P
F
L
G
V
-
L
G
M
Q
L
A
V
I
E
F
A
R
N
C
L
N
L
K
D
A
D
S
T
E
F
-
R
-
P
-
N
A
P
V
P
L
V
I
D
M
P
E
H
---------
N
--
P
G
-
N
L
G
G
T
M
R
L
G
I
R
R
T
V
F
K
-
T
E
N
S
I
L
R
K
L
Y
G
D
V
P
-
F
I
E
E
R
H
R
H
R
F
E
V
N
P
N
L
I
K
Q
F
E
Q
N
D
L
S
F
V
G
Q
D
V
D
G
D
R
M
E
I
I
E
L
--
A
N
H
P
Y
F
V
G
V
Q
F
H
P
E
F
S
S
R
P
M
K
P
S
P
P
Y
L
G
L
L
L
A
A
T
G
N
L
N
A
Y
--
31
PsiBlast_CBE
59.13
49%
-118
- C5 -
3IHL
2
PYRG2_HUMAN
B:
[2-272]
----
K
Y
I
L
V
T
G
G
V
I
S
G
I
G
K
G
I
I
A
S
S
I
G
T
I
L
K
S
C
G
L
R
V
T
A
I
K
I
D
P
Y
I
N
I
D
A
G
T
F
S
P
Y
E
H
G
E
V
F
V
L
N
D
G
G
E
--------------------------------------------
V
Q
V
V
P
H
I
T
D
A
V
Q
E
W
V
M
N
Q
A
K
VPVDG
N
K
--
E
--
E
------
P
Q
I
C
V
I
E
L
G
G
T
I
G
D
I
E
G
M
P
F
V
E
A
F
R
Q
F
Q
F
K
A
K
R
E
N
F
C
N
I
H
V
S
L
V
P
Q
L
S
A
T
G
E
Q
K
T
K
P
T
Q
N
S
V
R
A
L
R
G
L
G
L
S
P
D
L
I
V
C
R
S
S
T
P
I
E
M
A
V
K
E
K
I
S
M
F
C
H
V
N
P
E
Q
V
I
C
I
H
D
V
S
S
T
Y
R
V
P
V
L
L
E
E
Q
S
I
V
K
Y
F
K
E
R
L
H
L
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------