@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0172: (2015-11-29 )
MKPDIINPNFSVWVNASAGTGKTKILIDRVLRLLLENKRNIFCLTFTNAAANEMESRIHNILSKWAVCSDNELIASLEQLDLSLLLLQHHYPPSHPFLSSQCLTLRSRWPQTKNSEVFNHYLIQARRLFSELENLDLTIQTVHAFCYKLISSFPAEAGIVPNCTLSECKELHSIVFDKLLHNEAVQDSIKFIAAEVDENKLRDLLYTLCIKRSVSANNLEYVKGKLSAPDEIHGLQSEATEQIERLAEILSKGSKRDRNYSKMLDLTSSSFIQVADTRIQKLDSSATRWNDISIENLVKVFLKSESCEKKSISSIITKSTLEKFPGAEQVIENIQNAVFTHVRDINSYQIFKRTSSFLDIFKVYIDLYNSEKSKNALLDYNDIIDLATNLLSNPDYKNWVLFNLDQKIDHILVDEAQDNSISQWKIIANLCDEFFIRNDEKRTLFVVGDVKQSIYRFQGANPHLFNCMQQYFHTKSGGKDWISCQLEKSFRSTPETLTLVDRLFNNFREEISFVDSEIKHIPYRENDQGYVEIWPLLPRCKEEEQQALQIHLMHRKDYIITDRLLAQAIAHKIHNWLNEGRILVAKNRHIEPRDIMILVRQRNMLVDYVISELKKANIPVVGRDYFRIMDYIAVQDLIALTEFLLLPTNDLALANALKSPLFNFTEDDLFNIAYDRKEQSLWERLQNYSEDIYSKLNDLINLSHIESPLTLFTHILRTGKKKFAARLGLECFEVLDEFMNLVLQFENPSLQAFVQWIKENNPEIKNDMQSERNAVRIMTIHKSKGLQAPIVFLVDTNTVPKNSESIVLDAMGAPFLCGKNNNAYCDQVKREKKLEDYNEYLRLLYVALTRAEDELYILGKEPVQKGSWYDIITKYGEPYEKKYMELHQIFKEKVEVLCVNANYPYIYKKRDYFNIPAVLPPPNLSILFQHSPSPSQYPLLSPQCFDTGIHSFSPLDSSVTHWDDKKRNTWMTDGYTRGLIIHSILQYMPKIEKDRRKNWIGKYLDNINIRKNKDEIYRKILAFNEKYDYLFDLDGKSEITLSGTINGKPVLVRLDKLCITQDKAIIIDYKSHRNVSVSSLNEIKKQMLIYKTLVQEICPNKQVECMVIWVEDLTIQSDF
Atome Classification :
(20 SA)
--------.........----10........20........30..---...-..-----------.40........50........60........70-----.......----------------.80........90........100.......110.......120.......130.......140.......150.......160...---....170.......180.......190.....--..200.......210....-...220.......230.......240........250.......260..-.....270.......280.......290.......300.......310.......320.......330.......340---.........350.......360.......370..---.....380.......390.-...--..------.400.......410-.......420.......430.......440.......450.......460........470.......480.......490.......500.......510--.......520..----.....530.......540.......550......---.560--.......570.......580------..------...---.--..590.---......600.......610.......--620--.---.......630.......640....--...650.---......660-.........--------------670.-...------------.--..680----..----...----------.------.------------690-----------.........700------..-......710....-.--.-.-720.....----.--.-.-730--........740.....-------.----.------750-------------....---....--.-------760------...-..-------...770------.......780.......790..----..-----.---..---------800..---.....---810-.....---....-820-....----..----...830.......840.-......850....---.--------.------------.860.---------.-------------------------...--------..870.....-..880--------.........890.---....--..900...-....910...--------....-----920---------....---...930....-...940.......950.......960...------------.-----.--...970.......980.......990.......1000.....-.1010------..----.......1020--------.....---.---1030.......1040..-------------.------------------------------...1050.----------------------.....1060.------------------------------.....1070-----.-----....-----------..1080-...------....1090......1100.---------.....1110......----------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------MKPDIINPN----
F
S
V
W
V
NASAGTG
K
T
K
I
L
I
D
R
V
L
R
L
---
L
L
E-NK-----------R
N
I
F
C
L
T
FT
N
A
A
A
N
E
M
E
S
R
I
H
N
I
L
S
K
WAVCS
D
N
-----
E
L
I
A
S
L
E
----------------
Q
L
D
L
S
L
L
L
L
Q
HHYPPSHPF
L
S
S
Q
C
L
T
L
R
S
RWPQTK
N
S
E
V
F
N
H
Y
L
I
Q
A
R
R
L
F
S
E
L
ENLD
L
T
I
Q
T
V
H
A
F
C
Y
K
L
I
SSFPAEAGIVPNC
T
L
---
S
E
C
K
E
L
H
S
I
V
F
D
K
L
L
H
N
E
A
V
Q
D
S
I
K
F
I
A
A
EV
D
--
E
N
K
L
R
D
L
L
Y
T
L
C
I
KRSVSA-NN
L
E
Y
V
KGKLSA
P
D
E
IHG
L
Q
S
E
A
T
-
E
Q
I
E
R
L
A
E
I
L
SKGSKRDR
N
Y
S
K
M
L
-DLTSS
S
F
I
Q
V
A
D
T
R
I
Q
K
LDSSATRWNDI
S
I
E
N
L
V
K
V
F
L
KSESC
E
K
K
S
I
S
S
I
I
T
K
S
T
L
E
KFP
G
A
E
Q
V
I
E
N
I
Q
N
A
V
F
T
-----
H
V
RDI
N
S
Y
Q
I
F
K
R
T
S
S
F
L
D
I
F
K
V
Y
I
D
L
YNSEKSK---
N
A
LL
D
Y
N
D
I
I
D
L
A
T
N
L
LSN-PDY--K
N
------
W
V
L
F
NLDQK
I
D
H
IL-VDEAQDNSI
S
Q
W
K
I
I
A
N
L
C
D
E
F
F
IRNDEK
R
T
L
F
V
VG
D
V
K
Q
S
I
Y
RFQGAN-
P
H
L
F
N
C
M
Q
Q
Y
FHTKSGGKD
W
I
S
C
Q
L
E
K
S
FRSTP
E
T
L
T
L
V
D
R
L
F
N
N
F
R
E
E
I
S
--
F
V
D
S
E
I
KHIPYR----ENDQ
G
Y
V
E
I
WPLLPRC
K
E
E
E
Q
Q
A
L
Q
I
H
L
M
HRKD
Y
---
I
I
T
D
--
R
L
L
A
Q
A
I
A
H
K
I
H
N
W
L
NEG-
R
------
I
L
------
V
AK---N--RHIEPR---
D
I
M
I
L
V
RQR
N
M
L
V
D
Y
V
I
S
E
L
K
KANIP--VV---
G
---
R
D
Y
F
R
I
M
D
Y
I
A
V
Q
D
L
I
A
L
T
E
F
LLL--PT
N
D
L
A
L
---
A
N
A
L
K
S
P---LFNFTE
D
D
L
--------------
F
N
I
A
-YD
R
------------
K
--
E
Q
S
L
W
----
E
R
----
L
Q
N
----------
Y
------
S
------------
E
-------------
D
I
Y
S
K
L
N
D
L
I
N
-------
L
S
-
H
IE
S
P
L
T
L
F
T
H
I
L
-
R
--T-
G
-
K
-
K
K
F
A
A
R
----L--
G
-
L
-
E
C
---
F
E
V
L
D
E
F
M
N
L
V
L
QFEN-------P----
S
------
L
---------------
Q
A
F
V
---
Q
W
I
K--E-------NN-------PE
I
-
K
N
-------
D
M
Q
SER------
N
A
V
R
I
M
T
I
HKSKGLQA
P
I
V
F
L
V
----DT-----N---TV---------PKNSE---
S
I
V
L
D---A---MGA
P
F
---
L
CGK-N---N
N
A
Y
----
C
D
----
Q
V
K
R
E
K
K
L
E
D
Y
N
E
Y
L
R
L
-
L
Y
V
A
L
TRAE
D
E
L
Y
---
I
--------L------------GKEPV---------Q-------------------------KG
S
--------
W
Y
D
I
I
T
KYGE-
P
Y
E
----------
K
K
Y
M
E
L
H
Q
I
F
K
EK---V
E
V
L
--
C
VNANY
P
Y
-
I
Y
K
KRDYFNI--------PAVL-----PPP---------
N
L
S
I
---
L
F
QHSPSPSQ-YPLL
S
P
Q
C
F
D
TGIHSFSPLDSSVT-HWDD------------K-----K--RNTWMTDGYT
R
G
L
I
I
H
S
I
L
Q
Y
M
P
K
I
E
K
D
R
R
K
N
W
I
G
K
Y
L
DNIN-IR---------K
N
----
K
D
E
I
Y
R
K
I
L
A
F--------NEKY
D
---
Y
---
L
F
-DLDGK
S
E
I
T
L
S
G
TI-------------N------------------------------G
K
P
V
L
V
R
L
----------------------
D
K
LCITQD
K
A
------------------------------
I
I
I
D
YKSH------R-----NV
S
V
-----------
S
S
L
-
N
E
-
I
K
K
------
Q
M
L
I
Y
K
T
L
V
Q
E
ICPNKQ
V
E
---------
C
M
V
I
W
V
E
D
L
T
IQSDF----------------------
23
HHSearch
88.53
22%
-76
- C4 -
3U4Q
-
ADDA_BACSU
A:
[345-1230]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
Q
L
V
I
S
Y
G
K
R
F
E
A
A
K
Q
E
---
K
S
I
I
D
F
S
D
L
E
H
Y
C
L
A
I
L
T
A
-
E
N
D
RE
P
S
------
E
A
A
R
F
Y
Q
E
Q
F
H
E
V
L
-
V
D
E
Y
Q
D
T
N
L
V
Q
E
S
I
L
Q
L
V
T
S
G
P
E
----
E
T
G
N
L
F
M
V
G
D
V
K
Q
S
I
Y
R
F
R
L
A
E
-
P
L
L
F
L
S
K
Y
K
R
F
T
E
S
G
-
E
G
T
G
R
K
I
D
L
N
K
N
F
R
S
R
A
D
I
L
D
S
T
N
F
L
F
K
Q
L
M
G
G
K
I
GE
V
D
Y
D
E
Q
A
E
L
K
L
G
AAYP
D
N
D
E
T
E
T
E
------------
L
L
L
I
D
------------
L
E
T
V
--
Q
F
E
A
K
A
I
A
K
E
I
R
K
L
I
S
S
P
-
F
------
K
V
Y-----
K
K
T
---
H
--
R
N
I
Q
Y
R
---
D
I
V
I
L
L
R
S
M
P
W
A
-
P
Q
I
M
E
E
L
R
A
Q
G
I
P
--
V
Y
---
A
---
N
L
T
S
G
Y
F
E
A
V
E
V
A
V
A
L
S
V
L
K
V
I
D
N
--
P
Y
Q
D
I
P
L
---
A
S
V
L
R
S
P
---
I
V
G
A
D
E
N
E
L
--------------
S
L
I
R
-
L
E
N
------------
K
--
K
A
P
Y
Y
----
E
A
----
M
K
D
Y
L
A
A
GDRSD
E
L
Y
Q
----
K
------------
L
N
------------
T
F
Y
G
H
L
Q
K
W
R
A
-------
F
S
-
K
N
H
S
V
S
E
L
I
W
E
V
Y
-
R
D
T
K
-
Y
-
M
-
D
Y
V
G
G
M
----
P
--
G
-
G
K
Q
R
---
Q
A
N
L
R
V
L
Y
D
R
A
R
Q
Y
E
S
-------
T
AFR-
G
------
L
---------------
F
R
F
L
---
R
F
I
E
--
R
-------
M
Q
-------
E
R
G
D-------------
Q
E
------
D
V
V
R
L
M
T
I
H
S
S
K
G
L
E
F
P
V
V
F
V
A
----
G
L
-----
G
---
R
N
---------
F
N
M
M
D
LNK
S
Y
L
L
D
---
K
---
E
L
G
F
G
T
K
Y
I
H
P
Q
L
R
I
S
Y
P
T
L
P
----
L
I
----
A
M
K
K
K
M
R
R
E
L
L
S
E
E
L
R
V
-
L
Y
V
A
L
T
R
A
K
E
K
L
F
---
L
--------
I
------------
G
S
C
K
D
---------
H
Q
K
Q
L
A
K
W
Q
A
S
A
SQTDWLLP
E
F
D
R
Y
Q
A
R
T
--------
Y
L
D
F
I
G
P
A
L
A
-
R
H
R
--------------------
H
A
D
I
--
S
G
H
P
--
A
R
F
A
V
Q
M
I
H
S
Y
D
------
S
E
R
L
E
A
I
R
R
G
E
P
V
--------FAF
D
E
K
A
R
E
Q
L
S
W
---
T
Y
-
P
H
Q
E
V
T
Q
I
R
T
K
Q
S
V
S
-----------
D
E
Y
S
G
R
------------------YRRPA
F
--
M
M
K
K
G
L
T
A
A
E
K
G
T
A
M
H
T
V
M
Q
H
I
P
L
S
H
V
P
S
-
I
E
E
A
E
Q
T
V
H
R
L
Y
-
E
K
ELLT
E
E
Q
K
D
A
I
D---
I
E
E
I
-
V
Q
F
F
H
---------
T
E
I
G
G
---
Q
---
L
I
G
A
K
W
K
D
R
E
I
P
F
S
L
A
L
PAKEIYPDAHEAD
E
------------------------------
P
L
L
V
Q
G
I
I
----------------------
D
C
L
Y
E
T
E
D
G
L
------------------------------
Y
L
L
A
Y
K
S
D
------
R
-----
I
E
G
-GF
E
G
A
A
-----
P
I
L
K
K
R
-
Y
E
T
------
Q
I
Q
L
Y
T
K
A
V
E
Q
I
A
K
T
K
V
K
G
---------
C
A
L
Y
F
F
D
G
G
H
I
L
T
L
-----------------------
43
Fugue
81.16
18%
-70
- C4 -
3U4Q
-
ADDA_BACSU
A:
[10-1232]
---TWT
D
D
Q
W
N
A
I
V
S
T
G
----
Q
D
I
L
V
A
A
A
A
G
S
G
K
T
A
V
L
V
E
R
M
I
R
K
---
I
T
A
-
E
E
N
P
I
D
V------
D
R
L
L
V
V
T
F
T
N
A
S
A
A
E
M
K
H
R
I
A
E
A
L
E
K
E
L
V
Q
R
P
G
--------------------------------------------------------------------
S
L
H
I
R
R
Q
L
S
L
L
N
R
A
-----
S
I
S
T
L
H
S
F
C
L
Q
V
L
K
K
Y
Y
Y
L
I
D
L
D
P
G
F
R
I
A
D
Q
T
E
G
E
L
I
G
D
E
V
L
D
E
L
F
E
D
E
Y
A
K
G
E
K
A
F
F
E
L
V
D
R
YT
T
D
R
H
D
L
D
L
Q
F
L
V
K
Q
V
Y
E
Y
S
-
R
S
H
P
N
P
E
A
W
L
E
S
F
V
H
L
Y
D
V
S
E
K
S
A
-
I
E
E
L
P
F
Y
Q
Y
V
K
E
D
I
A
M
V
L
N
G
A
K
E
K
-
L
L
R
A
L
E
L
T
D
N
F
L
D
D
L
A
Q
I
D
E
L
I
Q
H
Q
D
--
D
F
S
E
L
Y
K
R
V
P
A
V
S
D
P
A
L
L
D
E
A
T
D
L
R
N
G
A
K
K
L
L
E
K
L
K
T
D
Y
--
F
T
R
S
P
E
Q
-----
H
L
K
S
L
A
--
E
M
K
P
V
I
E
T
L
V
Q
L
V
I
S
Y
G
K
R
F
E
A
A
K
Q
E
---
K
S
I
I
D
F
S
D
L
E
H
Y
C
L
A
I
L
T
A
-
E
N
D
--
R
E
PS----
E
A
A
R
F
Y
Q
E
Q
F
H
E
V
L
-
V
D
E
Y
Q
D
T
N
L
V
Q
E
S
I
L
Q
L
V
T
S
----
G
P
E
E
T
G
N
L
F
M
V
G
D
V
K
Q
S
I
Y
R
F
R
L
A
E
-
P
L
L
F
L
S
K
Y
K
R
F
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S
G
E
G
T
G
-
R
K
I
D
L
N
K
N
F
R
S
R
A
D
I
L
D
S
T
N
F
L
F
K
------
Q
--
L
M
G
G
K
I
G
E
V
D
Y
D
----
E
Q
A
E
L
K
L
G
-----
A
A
Y
P
D
N
D
E
T
E
T
E
L
L
L
I
D
L
E
T
V
---
Q
F
E
A
--
K
A
I
A
K
E
I
R
K
L
I
S
S
---
P
F
-
K
------
V
Y
------
K
K
T
---
H
--
R
N
I
Q
Y
R
---
D
I
V
I
L
L
R
S
M
P
-
W
A
P
Q
I
M
E
E
L
R
A
Q
G
I
P
--
V
Y
---
A
---
N
L
T
S
G
Y
F
E
A
V
E
V
A
V
A
L
S
V
L
K
V
I
D
N
--
P
Y
Q
D
I
P
L
---
A
S
V
L
R
S
P
---
I
V
G
A
D
E
N
E
L
--------------
S
L
I
R
-
L
E
N
------------
K
--
K
A
P
Y
Y
----
E
A
----
M
K
D
----------
Y
------
L
------------
A
A
GDRSD
E
L
Y
Q
K
L
N
T
F
Y
G
H
L
Q
K
W
R
A
-------
F
S
-
K
N
H
S
V
S
E
L
I
W
E
V
Y
-
R
--
D
T
K
-
Y
-
M
D
Y
V
G
G
----
M
PG
G
-
K
-
Q
R
---
Q
A
N
L
R
V
L
Y
D
R
A
R
Q
Y
E
S
-------
T
----
A
------
F
---------------
R
G
L
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---
R
F
L
R
--
F
-------
I
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-------
R
M
Q
-
E
R
-------
G
--
D
Q
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------
D
V
V
R
L
M
T
I
H
S
S
K
G
L
E
F
P
V
V
F
V
A
----
G
L
-----
G
RNF
N
M
---------
M
D
L
N
K
---
S
Y
L
L
D
---
K
EL
G
F
G
T
K
Y
---
I
H
P
Q
-
L
---
R
I
S
Y
P
T
L
P
L
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----
A
M
K
K
K
M
R
R
E
L
L
S
E
E
L
R
V
-
L
Y
V
A
L
T
R
A
K
E
K
L
F
---
L
--------
I
------------
G
S
C
K
D
---------
H
-------------------------
Q
K
Q
--------
L
A
K
W
Q
A
S
A
S
Q
-
T
D
W
LLP
E
F
D
R
Y
Q
A
R
T
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L
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F
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A
L
A
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H
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A
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S
--
G
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A
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A
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-
Q
M
I
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S
Y
D
S
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R
--------
L
E
A
I
R
RGEP
V
F
A
---------
F
D
E
K
---
A
R
E
Q
L
S
W
T
Y
P
-
H
Q
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V
T
Q
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T
K
Q
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V
S
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Y
S
G
R
Y
R
R
P
-
A
F
M
M
------------
K
-----
K
--
G
L
T
----
A
A
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K
G
T
A
M
H
T
V
M
Q
H
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-
L
S
H
V
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A
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Q
T
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H
R
L
Y
-
E
K
---------
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L
----
L
T
E
E
Q
K
D
A
I
D
I
--------
E
E
I
V
Q
---
F
---
F
H
-
T
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G
G
Q
L
I
G
A
K
W
K
D
-------------
R
------------------------------
E
I
P
F
S
L
A
L
PAKEIYPDAHEAD
E
P
L
L
V
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G
I
I
D
C
L
Y
E
T
E
D
G
L
------------------------------
Y
L
L
A
Y
K
S
D
------
R
IEGGF
E
G
A
A
-----------
P
I
L
-
K
K
R
Y
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T
------
Q
I
Q
L
Y
T
K
A
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I
A
-
K
T
K
V
K
---------
G
C
A
L
Y
F
F
D
G
G
H
I
L
T
L
----------------------
25
HHSearch
79.32
24%
-83
- C4 -
1PJR
-
PCRA_GEOSE
A:
[20-643]
------------
V
R
T
T
E
----
G
P
L
L
I
M
A
G
A
G
S
G
K
T
R
V
L
T
H
R
I
A
Y
L
---
M
A
E
K
H
V
AP---------
W
N
I
L
A
I
T
F
T
N
K
A
A
R
E
M
R
E
R
V
Q
S
L
L
G
G
A
----------------------------------------------------------------------------------------
A
E
-
D
V
W
I
S
T
F
H
S
M
C
V
R
I
L
R
R
D
I
D
R
I
G
I
N
R
N
F
S
I
---
L
D
P
T
D
Q
L
-
S
V
M
K
T
I
L
K
E
K
---------
N
I
-------
D
P
K
K
F
-----
E
-------------------------------------
P
R
T
------
I
L
G
T
-----
I
-
S
A
A
K
N
-----------------------------------
E
L
-
L
---------------
P
P
E
Q
---
F
A
----------------
K
R
----------
Y
Y
E
K
V
V
S
D
V
Y
Q
E
Y
Q
Q
R
L
L
R
---
N
H
S
L
D
F
D
D
L
I
M
T
T
I
Q
L
F
D
R
-
V
P
-----------
D
V
L
H
Y
Y
Q
Y
K
F
Q
Y
I
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-
I
D
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Y
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D
T
N
R
A
Q
Y
T
L
V
K
K
L
A
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R
-------
F
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N
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A
V
G
D
A
D
Q
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R
W
R
G
A
D
-
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Q
N
I
L
S
F
E
R
D
Y
P
N
------
A
K
V
I
L
L
E
Q
N
Y
R
S
T
K
R
I
L
Q
A
A
N
E
V
I
E
H
N
V
N
R
K
P
---
K
---------------------
R
I
W
T
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N
P
E
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K
P
--
I
L
Y
Y
---------
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---
A
M
N
E
--
A
D
E
A
Q
F
V
A
G
R
I
R
E
A
V
E
R
G
--------------------------
E
R
R
Y
R
---
D
F
A
V
L
Y
R
T
N
A
Q
S
-
R
V
M
E
E
M
L
L
K
A
N
I
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--
Y
Q
---
I
---
V
G
G
L
K
F
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D
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K
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K
D
I
L
A
Y
L
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A
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--
P
D
D
D
L
S
L
---
L
R
I
I
N
V
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---
K
R
G
I
G
A
S
T
I
--------------
D
-------------------------
L
F
----
E
A
----
L
G
E
LEMIGLG
A
--
K
A
A
G
---
A
------------
L
A
------------
A
F
R
S
Q
L
E
Q
W
T
Q
-------
L
Q
-
E
Y
V
S
V
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L
V
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V
L
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D
K
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-
Y
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-
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M
L
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I
--
E
-
A
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---
L
E
N
L
D
E
F
L
S
V
T
K
H
F
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N
-------
V
SDDK
S
------
L
---------------
I
A
F
L
---
T
D
L
A
--
L
-------
I
S
-------------------------
G
------
D
A
V
M
L
M
T
L
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A
A
K
G
L
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F
P
V
V
F
L
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----
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-----
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---
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G
---------
I
F
P
H
N
---
R
S
---------------------------------------------
L
E
D
D
D
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M
E
E
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R
R
L
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A
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V
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A
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E
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L
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---
L
--------
T
------------
S
A
Q
M
R
---------
T
L
FGNIQMDP----------------
P
S
R
--------
F
L
N
E
I
P
A
H
L
L
-
E
T
A
----------
S
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
74.29
16%
-65
- C4 -
1W36
1
RECB_ECOLI
B:
[1-1174]
-MSDVAET
L
D
P
L
R
L
P
L
Q
----
G
E
R
L
I
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A
S
A
G
T
G
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A
A
L
Y
L
R
L
---
L
L
G
-
L
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GSAAFPRPLTV
E
E
L
L
V
V
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A
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L
R
I
A
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L
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-----
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------------------------------------------
T
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N
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L
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L
L
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A
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M
D
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A
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A
V
F
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F
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R
M
L
N
L
N
A
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L
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L
L
R
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A
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V
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T
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L
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A
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P
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D
D
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---
L
A
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A
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Q
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V
A
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Q
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W
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I
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A
W
A
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----------------------------
E
E
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Q
L
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L
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P
R
H
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L
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-----
A
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L
L
A
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D
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---
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---
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R
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-----
H
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A
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A
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M
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A
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V
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A
--------
H
Y
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L
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W
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A
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M
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N
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V
N
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L
F
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A
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F
M
F
R
E
I
P
F
I
P
V
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----
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A
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L
R
F
V
F
K
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A
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M
W
L
M
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G
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C
G
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---
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D
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Q
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M
A
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C
A
A
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I
R
D
W
L
Q
A
G
-
Q
RGEALL
M
N
------
G
D
D
---
A
--
R
P
V
R
A
S
---
D
I
S
V
L
V
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R
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A
A
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A
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L
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L
---
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W
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P
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A
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A
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M
M
G
L
N
A
L
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T
L
N
N
D
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------------
A
--
W
D
V
V
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----
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----
F
D
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----------
Y
------
R
------------
Q
-------------
I
W
R
K
R
-----
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-------
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M
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P
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A
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L
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G
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-------------------------
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L
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A
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D
D
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---
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A
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A
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D
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-----
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T
L
---------
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R
L
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W
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S
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L
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-
Q
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A
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V
-
V
E
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-----
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P
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F
P
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A
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P
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L
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L
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F
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D
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L
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---------
Q
W
----
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P
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W
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G
V
S
L
S
---
Q
---
L
S
-
A
R
N
K
Q
V
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M
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F
Y
L
P
I
-------------
S
------------------------------
E
P
L
I
A
S
Q
L
----------------------
D
T
L
I
R
Q
F
D
P
L
SAGCPPLEFMQVRGMLKGFIDLVFRHEGRY
Y
L
L
D
Y
K
S
N
WLGEDS
S
-----
A
Y
T
Q
-----------
Q
A
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-
A
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A
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V
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QGIYTTRPNAGLIALMDEMFAG
2
PsiBlast_PDB
72.59
25%
-91
- C4 -
3U4Q
-
ADDA_BACSU
A:
[311-882]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
K
K
L
L
E
K
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K
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D
Y
F
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RS
P
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Q
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T
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L
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Q
L
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K
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---
K
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L
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Y
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L
A
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L
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A
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N
D
----REPS
E
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L
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L
L
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A
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K
L
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Q
--------
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E
----
A
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Q
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R
L
Y
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--------
E
L
L
T
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---
E
---
Q
K
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A
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Q
F
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------------------------------
I
G
G
Q
L
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G
A
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K
W
K
D
R
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P
F
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------------------------------
L
A
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P
A
K
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-----
P
D
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A
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---------
K
S
D
R
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G
F
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G
A
A
P
I
----------------------
1
PsiBlast_PDB
72.48
25%
-92
- C4 -
3U44
-
ADDA_BACSU
A:
[311-882]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
K
K
L
L
E
K
L
K
T
D
Y
F
T
RS
P
E
Q
H
L
K
S
L
A
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M
K
P
V
I
E
T
--
L
V
Q
L
V
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S
Y
G
K
R
F
E
A
A
K
Q
E
---
K
S
I
I
D
F
S
D
L
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H
Y
C
L
A
I
L
T
A
-
E
N
D
----REPS
E
-
A
A
R
F
Y
Q
E
Q
-
F
H
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V
L
-
V
D
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N
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S
I
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----
G
P
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F
L
F
K
Q
--------
L
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G
G
K
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D
Y
------
D
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A
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L
K
L
G
A
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P
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----------
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R
---
D
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L
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M
P
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Y
---
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S
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K
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G
L
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F
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----
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L
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---
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---
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Q
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G
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L
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D
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------------------------------
L
A
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D
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D
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G
F
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G
A
A
P
I
----------------------
4
PsiBlast_PDB
70.16
25%
-88
- C4 -
4CEJ
1
ADDA_BACSU
A:
[311-882]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
K
K
L
L
E
K
L
K
T
D
Y
F
T
RS
P
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Q
H
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L
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A
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Q
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V
Q
G
I
I
D
C
L
---------
Y
E
T
E
D
G
L
Y
L
L
A
Y
K
S
D
----------------------
24
HHSearch
69.78
17%
-69
* C4 *
1W36
1
RECB_ECOLI
B:
[330-1123]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
L
A
E
I
R
E
T
V
A
R
E
K
R
R
---
R
G
E
L
G
F
D
D
M
L
S
R
L
D
S
A
L
R
S
-
E
S
---
G
E
------
V
L
A
A
A
I
R
T
R
F
P
V
A
M
-
I
D
E
F
Q
D
T
D
P
Q
Q
Y
R
I
F
R
R
I
W
H
H
Q
-----
P
E
T
A
L
L
L
I
G
D
P
K
Q
A
I
Y
A
F
R
G
A
D
-
I
F
T
Y
M
K
A
R
S
E
V
H
--------
A
H
Y
T
L
D
T
N
W
R
S
A
P
G
M
V
N
S
V
N
K
L
F
S
Q
T
D
D
A
F
M
---
F
R
-
E
I
P
F
I
P
V
K
S---
A
G
K
N
Q
A
L
R
F
V
F
K
G
E
T
Q
P
A
--
M
K
M
W
L
M
E
G
E
S
-
C
G
V
---
G
D
Y
Q
--
S
T
M
A
Q
V
C
A
A
Q
I
R
D
W
L
Q
A
G
-
Q
------
R
G
EALLMN
G
D
D
---
A
--
R
P
V
R
A
S
---
D
I
S
V
L
V
R
S
R
Q
E
A
-
A
Q
V
R
D
A
L
T
L
L
E
I
P
--
S
V
---
Y
L--
S
N
R
D
S
V
F
E
T
L
E
A
Q
E
M
L
W
L
L
Q
A
V
M
T
--
P
E
R
E
N
T
L
---
R
S
A
L
A
T
S
---
M
M
G
L
N
A
L
D
I
--------------
E
T
L
N
-
N
D
-----------------
E
H
A
W
----
D
V
----
V
------------------------------------------------
V
E
E
F
D
G
Y
R
Q
-------
I
W
-
R
K
R
G
V
M
P
M
L
R
A
L
M
-
S
AR
N
-
I
-
A
-
E
N
L
L
A
T
----
A
--
G
-
G
E
R
R
---
L
T
D
I
L
H
I
S
E
L
L
Q
E
A
G
T
-------
Q
LE--
S
------
E
---------------
H
A
L
V
---
R
W
L
S
--
Q
-------
H
I
-------
L
E
P
-
D
S
NASSQQM
R
L
E
S
D
K
------
H
L
V
Q
I
V
T
I
H
K
S
K
G
L
E
Y
P
L
V
W
L
P
----
F
I
TNFRV
Q
---
E
Q
---------
A
F
Y
H
D
---
R
H
----------
S
F
E
A
V
---
L
D
L
N
-
A
------
A
-----
P
----
E
S
V
D
L
A
E
A
E
R
L
A
E
D
L
R
L
-
L
Y
V
A
L
T
R
S
V
W
H
C
S
---
L
--------
G
------------
V
A
P
L
V
---------
R
RRGDKKGDTDVH-------------
Q
S
A
--------
L
G
R
L
L
Q
K
G
E
P
-
Q
D
--------------------
A
A
G
L
---
R
T
C
I
EA
L
C
D
D
D
I
A
W
-
Q
T
A
Q
T
G
D
-
N
Q
--------
P
W
Q
V
-----
N
D
V
---------
S
T
A
E
---
L
-
N
A
K
T
L
Q
R
L
P
G
D
N
W
R
V
T
S
Y
S
G
L
Q
Q
--
R
G
H
G
I
A
Q
D
L
M
P
R
L
DVDAAGVASVVE
E
-----
P
TL
T
P
H
Q
F
P
R
G
A
S
P
G
T
F
L
H
S
L
F
E
D
L
D
F
T
Q
P
V
D
-
P
N
W
V
R
E
K
L
E
L
G
G
F
E
S
---------
Q
W
EPVL
T
E
W
I
-
T
A
V
L
Q
---------
A
P
L
N
E
TGV
S
LSQ
L
S
-
A
R
N
K
Q
V
E
M
E
F
Y
L
P
I
-------------
S
EPLIASQLDTLIRQFDPLSAGCPPLEFMQV
R
G
M
L
K
G
F
I
----------------------
D
L
V
F
R
H
E
G
R
Y
------------------------------
Y
L
L
D
Y
K
S
N
------
W
-----
L
G
E
D
SSAYTQQAMAA
A
M
Q
A
H
R
-
Y
D
L
------
Q
Y
Q
L
Y
T
L
A
L
H
R
Y
L
R
H
R
I
A
D
---------
Y
D
Y
E
H
H
F
G
G
V
I
Y
L
F
L
----------------------
3
PsiBlast_PDB
69.55
25%
-87
- C4 -
4CEI
2
ADDA_BACSU
A:
[311-882]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
K
K
L
L
E
K
L
K
T
D
Y
F
T
RS
P
E
Q
H
L
K
S
L
A
E
M
K
P
V
I
E
T
--
L
V
Q
L
V
I
S
Y
G
K
R
F
E
A
A
K
Q
E
---
K
S
I
I
D
F
S
D
L
E
H
Y
C
L
A
I
L
T
A
-
E
N
D
--
K
G
E
R
E
P
S
E
A
A
R
F
Y
Q
E
Q
-
F
H
E
V
L
-
V
D
E
Y
Q
D
T
N
L
V
Q
E
S
I
L
Q
L
V
T
S
----
G
P
E
E
T
G
N
L
F
M
V
G
D
V
K
Q
S
I
Y
R
F
R
L
A
E
-
P
L
L
F
L
S
K
Y
K
R
F
-
T
E
S
G
E
G
T
G
R
K
I
D
L
N
K
N
F
R
S
R
A
D
I
L
D
S
T
N
F
L
F
K
Q
--------
L
M
G
G
K
I
G
E
V
D
Y
------
D
E
Q
A
E
L
K
L
G
A
A
Y
P
D
N
D
E
T
E
T
E
L
L
L
I
D
N
------AEE
L
E
T
V
--
Q
F
E
A
K
A
I
A
K
E
I
R
K
L
I
S
S
P
F
K
------
V
Y
------
D
G
K
K
K
T
H
--
R
N
I
Q
Y
R
---
D
I
V
I
L
L
R
S
M
P
W
-
A
P
Q
I
M
E
E
L
R
A
Q
G
I
P
--
V
Y
---
A
NLT
S
G
Y
F
E
-----
A
V
E
V
A
V
A
L
S
V
L
K
V
I
D
N
P
Y
Q
D
I
P
L
---
A
S
V
L
R
S
P
---
I
V
G
A
D
E
N
E
L
--------------
S
L
I
R
-
L
E
N
------------
K
--
K
A
P
Y
Y
----
E
A
----
M
K
D
----------
Y
L
A
A
GDR
S
------------
D
-------------
E
L
Y
Q
K
L
N
T
F
Y
G
H
L
Q
K
W
R
A
F
S
-
K
N
H
S
V
S
E
L
I
W
E
V
Y
-
R
--
D
-
T
-
K
Y
M
D
Y
V
G
G
----
M
PG
G
-
K
-
Q
R
---
Q
A
N
L
R
V
L
Y
D
R
A
R
Q
Y
E
S
-------
T
----
A
------
F
---------------
R
G
L
F
---
R
F
L
R
F
I
E
-------
R
M
-------
Q
E
R
-
G
D
-------
D
L
G
T
A
R
GLSEQE
D
V
V
R
L
M
T
I
H
S
S
K
G
L
E
F
P
V
V
F
V
A
GLGR
N
F
-----
N
---
M
M
---------
D
L
N
-
K
---
S
Y
L
L
D
KEL
G
---
F
G
T
K
Y
---
I
H
P
Q
-
L
---
R
I
S
Y
----
P
T
L
P
L
I
A
M
K
K
K
M
R
R
E
L
L
S
E
E
L
R
V
-
L
Y
V
A
L
T
R
A
K
E
K
L
F
---
L
--------
I
------------
G
S
C
K
D
---------
H
-------------------------
Q
K
Q
--------
L
A
K
W
Q
A
S
A
S
Q
-
T
D
W
----------
L
L
P
E
F
D
R
Y
Q
A
R
T
Y
---
L
D
F
I
--
G
P
A
L
A
R
H
R
-
D
L
H
A
D
I
S
G
H
P
--------
A
R
F
A
-----
V
Q
M
---------
I
H
S
Y
---
D
L
L
E
K
S
E
R
L
E
-
A
I
R
R
G
E
P
V
P
G
S
F
A
F
D
E
K
A
R
E
Q
L
S
W
-
T
Y
P
H
------------
Q
-----
E
--
V
T
Q
I
R
T
K
Q
S
V
S
E
I
L
Y
R
R
P
A
F
M
M
K
K
G
L
T
A
A
E
K
G
T
A
M
H
T
V
M
Q
H
I
-
P
L
---------
S
H
----
V
P
S
I
E
E
A
E
Q
T
V
--------
H
R
L
Y
E
---
K
---
E
L
-
L
T
E
E
Q
K
D
A
I
D
I
E
E
I
-------------
V
------------------------------
Q
F
F
H
T
E
I
G
----------------------
G
Q
L
I
G
A
K
W
K
D
------------------------------
R
E
I
P
F
S
L
A
------
L
-----
P
A
K
E
-----------
I
Y
P
-
D
A
-
H
E
A
------
D
E
P
L
L
V
Q
G
I
I
D
C
L
Y
E
T
E
D
G
---------
L
Y
L
L
A
Y
K
S
D
R
I
E
A
A
P
----------------------
49
Fugue
66.93
19%
-31
- C3 -
4WD9
-
NISB_LACLL
A:
[5-1006]
S
F
K
A
Q
P
F
L
V
R
N
T
I
L
C
P
N
D
K
R
S
F
T
E
Y
T
Q
V
I
E
T
V
S
K
N
K
V
F
L
E
Q
L
L
L
A
N
P
K
L
Y
D
-
V
M
-----------
Q
K
Y
N
A
G
L
L
K
K
K
R
V
K
K
L
F
E
S
I
Y
K
Y
Y
K
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S
Y
L
R
S
T
P
FGLF
S
E
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S
I
G
V
F
S
K
S
S
Q
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G
K
T
T
K
GI
R
L
D
T
Q
W
L
I
R
L
V
H
K
--
M
E
V
D
F
S
K
K
L
S
F
T
R
N
N
A
N
Y
K
F
G
D
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F
Q
V
Y
T
I
N
S
S
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L
E
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N
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Y
T
N
V
Y
Q
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F
C
E
N
D
Y
Q
K
Y
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D
I
C
E
T
V
T
L
C
Y
G
---
D
E
Y
R
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L
S
E
Q
Y
L
G
S
L
I
V
N
-------
H
Y
L
I
S
N
L
Q
--
K
D
L
L
S
D
F
S
W
N
T
F
L
T
K
V
E
A
I
D
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D
K
K
Y
I
I
P
L
K
K
V
Q
K
F
I
Q
E
Y
S
E
I
E
I
G
E
G
I
E
K
L
K
E
I
Y
Q
E
M
S
Q
I
L
E
N
D
N
Y
I
Q
I
D
L
I
S
D
S
E
I
N
F
------------
D
V
K
Q
K
Q
Q
L
E
H
L
A
E
F
L
G
N
T
T
K
S
V
R
R
T
Y
L
D
D
Y
K
D
K
F
I
E
K
Y
-
G
V
D
Q
E
V
Q
--
I
T
E
L
F
D
-----
S
T
F
G
I
G
A
P
Y
N
Y
N
H
P
R
N
---------
D
F
Y
E
S
E
P
S
T
------
L
Y
Y
S
E
E
E
R
E
K
Y
L
S
M
Y
V
-
E
A
V
--
K
N
------
H
N
V
I
N
L
D
D
L
E
S
H
Y
Q
K
M
D
L
E
K
K
S
E
L
Q
G
L
E
L
F
L
N
L
A
K
E
Y
------
E
K
D
I
F
I
L
G
D
I
V
G
N
-
N
N
L
G
G
A
----------------
S
G
R
F
S
A
L
S
P
E
L
T
S
Y
H
R
T
I
V
D
S
V
E
R
E
N
E
N
K
E
I
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S
C
E
I
V
--
F
L
P
E
N
I
R
H
A
N
V
M
----
H
T
S
I
M
R
R
K
V
L
P
F
F
T
S
T
S
H
N
E
V
L
-----------------------------------
L
T
N
I
-
Y
------
I
G
------
I
D
E
---
K
--
E
K
F
Y
A
R
---
D
I
----
S
T
Q
E
V
L
K
F
Y
I
T
S
M
Y
N
K
T
-------------------------------------
L
--
F
S
N
E
L
R
F
---
L
Y
E
I
----------
S
L
D
D
K
--------------
F
G
----------------------
N
L
P
W
----
E
L
----
I
Y
R
----------
D
------
F
------------
D
-------------
Y
I
P
R
L
V
F
D
E
I
V
-------
I
S
-
P
A
K
W
K
I
W
-----
G
-
R
--
D
-
V
-
N
-
S
K
M
T
I
R
----
E
--
L
-
I
-
Q
S
---
K
E
I
P
K
E
F
Y
I
V
-----
N
-------
G
----
D
------
N
---------------
K
V
Y
L
---
S
Q
-------------------------
K
N
-------
P
L
D
M
E
I
------
L
E
S
A
I
K
K
S
S
K
R
K
D
F
I
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L
Q
E
Y
F
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----
D
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-----
N
---
I
I
---------
N
K
G
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---
G
R
V
A
D
---
V
---
V
-
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P
F
---
I
R
A
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---
R
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----
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----
V
E
R
R
E
K
L
--
P
F
N
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W
L
Y
L
K
L
Y
I
S
I
N
R
Q
N
E
F
L
L
SY
L
P
--------
D
------------
I
Q
K
I
V
---------
A
-------------------------
N
L
G
--------
G
N
L
F
F
L
R
Y
T
D
-
P
------------
K
P
H
I
R
L
R
I
K
C
S
D
------
L
F
--
L
A
Y
G
S
I
L
E
-
I
L
K
R
S
R
K
N
R
I
-----------
M
-----
S
T
F
---------
D
I
S
I
---
Y
D
Q
E
V
E
R
Y
G
G
-
F
D
T
L
--
E
L
S
E
A
I
F
C
A
D
S
K
I
I
P
N
L
L
-
T
L
I
K
------------
D
-----
T
--
N
N
D
W
K
V
D
D
V
S
I
-
L
V
N
Y
L
Y
L
K
C
F
F
Q
N
D
N
K
K
I
L
N
F
L
N
L
V
G
D
Q
I
F
-
Y
D
---------
K
N
----
F
K
E
L
K
H
A
I
K
N
L
--------
F
L
K
M
I
---
A
-----------------
Q
D
F
-------------
E
------------------------------
L
Q
K
V
Y
S
I
I
----------------------
D
S
I
I
H
V
H
N
N
R
------------------------------
L
I
-----------------------------------
G
-
I
E
-
R
D
K
------
E
K
L
I
Y
Y
T
L
Q
R
L
F
V
S
E
E
T
K
D
-------------
F
N
L
D
L
V
S
V
S
K
-----------------------
26
HHSearch
66.06
19%
-75
- C4 -
3LFU
2
UVRD_ECOLI
A:
[170-638]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
Q
K
V
Y
Q
A
Y
Q
E
A
C
D
R
---
A
G
L
V
D
F
A
E
L
L
L
R
A
H
E
L
W
L
N
-
K
P
-----------
H
I
L
Q
H
Y
R
E
R
F
T
N
I
L
-
V
D
E
F
Q
D
T
N
N
I
Q
Y
A
W
I
R
L
L
A
G
D
-------
T
G
K
V
M
I
V
G
D
D
D
Q
S
I
Y
G
W
R
G
A
Q
-
V
E
N
I
Q
R
F
L
N
D
F
P
G
------
A
E
T
I
R
L
E
Q
N
Y
R
S
T
S
N
I
L
S
A
A
N
A
L
I
E
N
N
N
G
R
L
G
---
K
---------------------
K
L
W
T
D
G
A
D
G
E
P
--
I
S
L
Y
---------
C
---
A
F
N
E
--
L
D
E
A
R
F
V
V
N
R
I
K
T
W
Q
D
N
---------------------------
G
G
A
L
A
---
E
C
A
I
L
Y
R
S
N
A
Q
S
-
R
V
L
E
E
A
L
L
Q
A
S
M
P
--
Y
R
---
I
---
Y
G
G
M
R
F
F
E
R
Q
E
I
K
D
A
L
S
Y
L
R
L
I
A
N
--
R
N
D
D
A
A
F
---
E
R
V
V
N
T
P
---
T
R
G
I
G
D
R
T
L
--------------
D
V
V
R
-
Q
T
S
------------
R
D
R
Q
L
T
L
W
----
Q
A
----
C
R
E
----------
L
L
Q
E
K--
A
LA
G
R
A
A
S
A
----
L
Q
------------
R
F
M
E
L
I
D
A
L
A
Q
-------
E
T
-
A
D
M
P
L
H
V
Q
T
D
R
V
I
-
K
D
S
G
-
L
-
R
-
T
M
Y
E
Q
E
----
K
G-
E
K
G
Q
T
R
---
I
E
N
L
E
E
L
V
T
A
T
R
Q
F
S
--------
E
----
D
------
L
---------------
M
P
L
Q
---
A
F
L
S
--
H
-------
A
A
-------
L
E
--
G
E
G------
Q
A
D
T
W
Q
------
D
A
V
Q
L
M
T
L
H
S
A
K
G
L
E
F
P
Q
V
F
I
V
----
G
M
-----
E
---
E
G
---------
M
F
P
S
Q
---
M
S
---------------------------------------------
L
--
G
G
R
L
E
E
E
R
R
L
-
A
Y
V
G
V
T
R
A
M
Q
K
L
T
---
L
--------
T
------------
Y
A
E
T
R
R
L
YG
K
E
V
Y
H
R
-------------------------
P
S
R
--------
F
I
G
E
L
P
E
E
C
V
-
E
E
V
----------
R
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
65.66
24%
-86
- C4 -
1W36
-
RECB_ECOLI
B:
[342-809]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
R
R
---
R
G
E
L
G
F
D
D
M
L
S
R
L
D
S
A
L
R
S
--
E
S
--
G
E
------
V
L
A
A
A
I
R
T
R
F
P
V
A
M
-
I
D
E
F
Q
D
T
D
P
Q
Q
Y
R
I
F
R
R
I
W
-----
H
H
Q
P
E
T
A
L
L
L
I
G
D
P
K
Q
A
I
Y
A
F
R
G
A
D
-
I
F
T
Y
M
K
A
R
S
E
V
H
A
H
--------
Y
T
L
D
T
N
W
R
S
A
P
G
M
V
N
S
V
N
K
L
F
S
Q
T
D
D
--
A
--
F
M
F
R
E
I
P
F
I
P
V
K
----
S
A
G
K
N
Q
A
----
L
R
F
V
F
K
G
E
T
Q
P
A
M
K
M
W
L
M
E
G
E
S
C
---
G
V
G
D
YQ
S
T
M
A
Q
V
C
A
A
Q
I
R
D
W
L
Q
A
G
-
Q
RGEA--
L
L
------
M
N
G
---
D
DA
R
P
V
R
A
S
---
D
I
S
V
L
V
R
S
R
Q
E
A
A
Q
-
V
R
D
A
L
T
L
L
E
I
P
--
S
V
YLS
N
---
R
D
--
S
V
F
E
T
L
E
A
Q
E
M
L
W
L
L
Q
A
V
M
T
--
P
E
R
E
N
T
L
---
R
S
A
L
A
T
S
---
M
M
G
L
N
A
L
D
I
--------------
E
T
L
N
-
N
D
-----------------
E
H
A
W
DVVV
E
E
----
F
D
G
----------
Y
------
R
------------
Q
--------------
I
W
R
K
R
G
V
M
P
M
-------
L
R
-
A
L
M
S
A
R
N
I
A
E
N
L
L
-
A
--
T
-
A
-
G
-
G
E
R
R
L
T
----
D
--
I
-
L
-
H
I
---
S
E
L
L
Q
E
A
G
T
---
Q
L
E
-------------
S
------
E
---------------
H
A
L
V
---
R
W
L
S
--
Q
HILEPDS
N
A
-------
S
S
Q
-
Q
M
-------
R
L
E
S
D
K
------
H
L
V
Q
I
V
T
I
H
K
S
K
G
L
E
Y
P
L
V
W
L
P
----
F
I
-----
T
---
N
F
RVQEQAFYH
D
R
H
S
F
---
E
A
V
L
D
---
L
---
N
A
A
P
---------------
E
S
----
V
D
----
L
A
E
A
E
R
L
A
E
D
----
L
R
L
-
L
Y
V
A
L
T
R
S
V
W
H
C
S
---
L
--------
G
------------
V
A
P
L
V
---------
R
-------------------------
R
R
G
--------
D
K
K
G
D
T
D
V
H
Q
-
S
A
L
----------
G
R
L
L
Q
K
G
E
P
Q
D
A
A
---
G
L
R
T
--
C
I
E
A
L
C
D
D
-
D
I
A
W
Q
T
A
Q
T
G
--------
D
N
Q
P
-----
W
Q
V
---------
N
D
V
S
---
T
A
E
L
N
A
K
T
L
Q
-
R
L
P
G
D
N
W
R
V
T
S
Y
S
G
L
Q
Q
R
G
H
G
I
A
Q
-
D
L
M
P
------------
R
-----
L
--
D
V
D
A
A
G
V
A
S
V
V
E
E
P
T
L
T
P
H
Q
F
P
R
G
A
S
P
G
T
F
L
H
S
L
F
E
D
L
D
F
T
Q
-
P
V
---------
D
P
----
N
W
V
R
E
K
L
E
L
G
G
--------
F
E
S
Q
W
---
E
---
P
V
-
L
T
E
W
I
T
A
V
L
Q
A
P
L
N
-------------
E
------------------------------
T
G
V
S
L
S
Q
L
----------------------
S
A
R
N
K
Q
V
E
M
E
------------------------------
F
Y
L
P
I
S
E
P
------
L
-----
I
A
S
Q
-----------
L
D
T
-
L
I
-
R
Q
F
------
D
P
L
S
A
G
C
P
P
L
E
F
M
Q
V
R
G
M
L
---------
K
G
F
I
D
L
V
F
R
H
E
G
R
Y
Y
----------------------
6
PsiBlast_PDB
64.73
24%
-88
- C4 -
3K70
-
RECB_ECOLI
B:
[342-809]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
R
R
---
R
G
E
L
G
F
D
D
M
L
S
R
L
D
S
A
L
R
S
--
E
S
--
G
E
------
V
L
A
A
A
I
R
T
R
F
P
V
A
M
-
I
D
E
F
Q
D
T
D
P
Q
Q
Y
R
I
F
R
R
I
W
-----
H
H
Q
P
E
T
A
L
L
L
I
G
D
P
K
Q
A
I
Y
A
F
R
G
A
D
-
I
F
T
Y
M
K
A
R
S
E
V
H
A
H
--------
Y
T
L
D
T
N
W
R
S
A
P
G
M
V
N
S
V
N
K
L
F
S
Q
T
D
D
--
A
--
F
M
F
R
E
I
P
F
I
P
V
K
----
S
A
G
K
N
Q
A
----
L
R
F
V
F
K
G
E
T
Q
P
A
M
K
M
W
L
M
E
G
E
S
C
---
G
V
G
D
YQ
S
T
M
A
Q
V
C
A
A
Q
I
R
D
W
L
Q
A
G
-
Q
RGEA--
L
L
------
M
N
G
---
D
DA
R
P
V
R
A
S
---
D
I
S
V
L
V
R
S
R
Q
E
A
A
Q
-
V
R
D
A
L
T
L
L
E
I
P
--
S
V
YLS
N
---
R
D
--
S
V
F
E
T
L
E
A
Q
E
M
L
W
L
L
Q
A
V
M
T
--
P
E
R
E
N
T
L
---
R
S
A
L
A
T
S
---
M
M
G
L
N
A
L
D
I
--------------
E
T
L
N
-
N
D
-----------------
E
H
A
W
DVVV
E
E
----
F
D
G
----------
Y
------
R
------------
Q
--------------
I
W
R
K
R
G
V
M
P
M
-------
L
R
-
A
L
M
S
A
R
N
I
A
E
N
L
L
-
A
--
T
-
A
-
G
-
G
E
R
R
L
T
----
D
--
I
-
L
-
H
I
---
S
E
L
L
Q
E
A
G
T
---
Q
L
E
-------------
S
------
E
---------------
H
A
L
V
---
R
W
L
S
--
Q
HILEPDS
N
A
-------
S
S
Q
-
Q
M
-------
R
L
E
S
D
K
------
H
L
V
Q
I
V
T
I
H
K
S
K
G
L
E
Y
P
L
V
W
L
P
----
F
I
-----
T
---
N
F
RVQEQAFYH
D
R
H
S
F
---
E
A
V
L
D
---
L
---
N
A
A
P
---------------
E
S
----
V
D
----
L
A
E
A
E
R
L
A
E
D
----
L
R
L
-
L
Y
V
A
L
T
R
S
V
W
H
C
S
---
L
--------
G
------------
V
A
P
L
V
---------
R
-------------------------
R
R
G
--------
D
K
K
G
D
T
D
V
H
Q
-
S
A
L
----------
G
R
L
L
Q
K
G
E
P
Q
D
A
A
---
G
L
R
T
--
C
I
E
A
L
C
D
D
-
D
I
A
W
Q
T
A
Q
T
G
--------
D
N
Q
P
-----
W
Q
V
---------
N
D
V
S
---
T
A
E
L
N
A
K
T
L
Q
-
R
L
P
G
D
N
W
R
V
T
S
Y
S
G
L
Q
Q
R
G
H
G
I
A
Q
-
D
L
M
P
------------
R
-----
L
--
D
V
D
A
A
G
V
A
S
V
V
E
E
P
T
L
T
P
H
Q
F
P
R
G
A
S
P
G
T
F
L
H
S
L
F
E
D
L
D
F
T
Q
-
P
V
---------
D
P
----
N
W
V
R
E
K
L
E
L
G
G
--------
F
E
S
Q
W
---
E
---
P
V
-
L
T
E
W
I
T
A
V
L
Q
A
P
L
N
-------------
E
------------------------------
T
G
V
S
L
S
Q
L
----------------------
S
A
R
N
K
Q
V
E
M
E
------------------------------
F
Y
L
P
I
S
E
P
------
L
-----
I
A
S
Q
-----------
L
D
T
-
L
I
-
R
Q
F
------
D
P
L
S
A
G
C
P
P
L
E
F
M
Q
V
R
G
M
L
---------
K
G
F
I
D
L
V
F
R
H
E
G
R
Y
Y
----------------------
7
PsiBlast_PDB
64.50
25%
-79
- C4 -
3PJR
2
?
A:
[160-617]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
A
K
R
A
S
T
Y
Y
E
--
K
V
V
S
D
V
Y
Q
E
Y
Q
Q
R
L
L
R
N
H
S
L
D
F
D
D
L
I
M
T
T
I
Q
L
F
D
R
V
P
D
------------
V
L
H
Y
Y
Q
Y
K
F
Q
Y
I
H
-
I
D
E
Y
Q
D
T
N
R
A
Q
Y
T
L
V
K
K
L
A
E
R
F
-------
Q
N
I
C
A
V
G
D
A
D
Q
S
I
Y
R
W
R
G
A
D
I
Q
N
I
L
S
F
E
R
D
Y
P
N
A
K
V
-------
I
L
L
E
Q
N
Y
R
S
T
K
R
I
L
Q
A
A
N
E
V
------------
I
E
H
N
V
N
R
K
P
K
R
------------
I
W
T
E
N
P
----
E
G
K
P
I
L
Y
Y
E
A
M
N
E
A
D
E
------------
A
Q
F
V
A
G
R
I
R
E
A
V
E
R
G
------------------
E
---
R
--
R
Y
---
R
---
D
F
A
V
L
Y
R
T
-
N
A
Q
S
R
V
M
E
E
M
L
L
K
A
N
I
P
Y
Q
I
V
---
G
---
G
--
L
K
F
Y
D
R
K
E
I
K
D
I
L
A
Y
L
R
V
I
A
N
--
P
D
D
D
L
S
L
L
R
I
I
N
V
P
K
R
G
---
I
G
A
S
T
I
D
K
L
--------------
V
R
Y
A
-
A
D
H
---------------
E
L
S
L
F
----
E
A
----
L
G
E
----------
L
------
E
M
I
G
L
G
A
K
A
A
G
A
L
A
-------------
A
F
R
S
Q
L
E
Q
W
T
Q
-------
L
Q
-
E
Y
V
S
V
T
E
L
V
E
E
V
L
D
K
--
S
-
G
Y
R
-
E
M
L
K
A
E
----
R
--
T
-
I
-
E
A
Q
S
R
L
E
N
L
D
E
F
L
S
V
T
K
H
F
E
N
VSDD---
K
----
S
------
L
---------------
I
A
F
L
T
D
L
A
L
I
S
--
D
-------
L
D
-------
E
----
T
-------
E
Q
A
A
E
G
------
D
A
V
M
L
M
T
L
H
A
A
K
G
L
E
F
P
V
V
F
L
I
GM--
E
E
-----
G
---
I
F
---------
P
H
N
--------------------------------------------------
R
S
L
E
D
D
D
E
M
E
E
E
R
R
L
-
A
Y
V
G
I
T
R
A
E
E
E
L
V
---
L
--------
T
------------
S
A
Q
M
R
---------
T
-------------------------
L
F
G
--------
N
I
Q
M
D
P
P
S
R
F
-
L
N
E
----------
I
P
A
H
L
L
E
T
A
S
R
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
63.49
21%
-73
- C4 -
2IS2
1
UVRD_ECOLI
A:
[172-612]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
Y
-
Q
A
Y
Q
E
A
C
D
R
---
A
G
L
V
D
F
A
E
L
L
L
R
A
H
E
L
W
L
N
------
K
P
------
H
I
L
Q
H
Y
R
E
R
F
T
N
I
L
-
V
D
E
F
Q
D
T
N
N
I
Q
Y
A
W
I
R
L
L
A
G
D
-------
T
G
K
V
M
I
V
G
D
D
D
Q
S
I
Y
G
W
R
G
A
Q
----
V
E
N
I
Q
R
F
L
N
D
F
P
G
A
E
---
T
I
R
L
E
Q
N
Y
R
S
T
S
N
I
L
S
A
A
N
A
L
I
E
N
N
N
G
R
L
G
--------
K
K
L
W
T
D
----
G
A
D
G
E
P
I
S
L
Y
C
A
F
N
E
L
D
E
----------------------------
A
R
F
V
V
N
R
I
K
T
W
Q
D
N
G
-
G
------
A
L
------
A
-----------------
E
C
A
I
L
Y
R
S
-
N
A
Q
S
R
V
L
E
E
A
L
L
Q
A
S
M
P
--
Y
R
---
I
---
Y
G
G
M
R
F
F
E
R
Q
E
I
K
D
A
L
S
Y
L
R
L
I
V
N
--
R
N
D
D
A
A
F
---
E
R
V
V
N
T
P
TRG
I
G
D
R
T
L
D
V
V
--------------
R
Q
T
S
-
R
D
R
QLT
L
W
Q
A
C
R
E
L
L
Q
--
E
K
A
L
A
----
G
R
A
A
S
A
L
Q
R
----------
F
------
M
------------
E
-------------
L
I
D
A
L
A
Q
E
T
A
D
-------
M
P
L
H
V
Q
T
D
R
V
I
K
D
S
G
L
-
R
--
T
-
M
-
Y
-
E
Q
E
K
G
E
----
K
--
G
-
Q
-
T
R
---
I
E
N
L
E
E
L
V
T
A
T
R
Q
F
S
Y
-------------DEDLM
P
L
---------------
Q
A
F
L
---
S
H
A
A
--
L
-------
E
A
-------
G
E
G
-
Q
A
-------
D
--
T
W
Q
------
D
A
V
Q
L
M
T
L
H
S
A
K
G
L
E
F
P
Q
V
F
I
V
----
G
M
-----
E
---
E
G
---------
M
F
P
S
Q
----
M
S
L
D
---
E
---
G
G
-----------------------------------
R
L
E
---
E
E
R
R
L
-
A
Y
V
G
V
T
R
A
M
Q
K
L
T
---
L
--------
T
------------
Y
A
E
T
R
---------
R
-------------------------
L
Y
G
--------
K
E
V
Y
H
R
P
S
R
F
-
I
G
E
----------
L
P
E
E
C
V
E
E
V
R
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
63.46
21%
-80
- C4 -
1UAA
1
REP_ECOLI
A:
[162-635]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
F
A
H
C
Y
G
L
Y
D
A
H
L
K
A
---
C
N
V
L
D
F
D
D
L
I
L
L
P
T
L
L
L
Q
A
-
N
E
-----------
E
V
R
K
R
W
Q
N
K
I
R
Y
L
L
-
V
D
E
Y
Q
D
T
N
T
S
Q
Y
E
L
V
K
L
L
V
G
S
-------
R
A
R
F
T
V
V
G
D
D
D
Q
S
I
Y
S
W
R
G
A
R
-
P
Q
N
L
V
L
L
S
Q
D
F
P
A
------
L
K
V
I
K
L
E
Q
N
Y
R
S
S
G
R
I
L
K
A
A
N
I
L
I
A
N
N
P
H
V
F
E
---
K
---------------------
R
L
F
S
E
L
G
Y
G
A
E
--
L
K
V
L
---------
S
---
A
N
N
E
--
E
H
E
A
E
R
V
T
G
E
L
I
A
H
H
F
V
--------------------------
N
K
T
Q
Y
K
---
D
Y
A
I
L
Y
R
G
N
H
Q
S
-
R
V
F
E
K
F
L
M
Q
N
R
I
P
--
Y
K
---
I
---
S
G
G
T
S
F
F
S
R
P
E
I
K
D
L
L
A
Y
L
R
V
L
T
N
--
P
D
D
D
S
A
F
---
L
R
I
V
N
T
P
---
K
R
E
I
G
P
A
T
L
--------------
K
K
L
G
-
E
W
A
------------
M
T
R
N
K
S
M
F
----
T
A
----
S
F
D
MGLSQTLSG-
R
G
Y
----
E
A
-----------
L
T
------------
R
F
T
H
W
L
A
E
I
Q
R
-------
L
A
--
E
R
E
P
I
A
A
V
R
D
L
I
-
H
G
M
D
-
Y
-
E
-
S
W
L
Y
E
T
SPS
P
K
--
A
-
A
E
M
R
---
M
K
N
V
N
Q
L
F
S
W
M
T
E
M
L
E
GSELDEP
M
----
T
------
L
---------------
T
Q
V
V
---
T
R
F
T
--
L
-------
R
D
-------
M
M
E
-
R
----------
E
E
E
L
------
D
Q
V
Q
L
M
T
L
H
A
S
K
G
L
E
F
P
Y
V
Y
M
V
----
G
M
-----
E
---
E
G
---------
F
L
P
H
Q
---
S
----------------------------------------------
S
I
D
E
D
N
I
D
E
E
R
R
L
-
A
Y
V
G
I
T
R
A
Q
K
E
L
T
---
F
--------
T
------------
L
C
K
E
R
RQYGELV--
R
PE-----------------------
P
S
R
--------
F
L
L
E
L
P
Q
D
D
L
-
I
W
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
63.45
21%
-70
- C4 -
2IS1
8
UVRD_ECOLI
A:
[172-612]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
Y
-
Q
A
Y
Q
E
A
C
D
R
---
A
G
L
V
D
F
A
E
L
L
L
R
A
H
E
L
W
L
N
------
K
P
------
H
I
L
Q
H
Y
R
E
R
F
T
N
I
L
-
V
D
E
F
Q
D
T
N
N
I
Q
Y
A
W
I
R
L
L
A
G
D
-------
T
G
K
V
M
I
V
G
D
D
D
Q
S
I
Y
G
W
R
G
A
Q
----
V
E
N
I
Q
R
F
L
N
D
F
P
G
A
E
---
T
I
R
L
E
Q
N
Y
R
S
T
S
N
I
L
S
A
A
N
A
L
I
E
N
N
N
G
R
L
G
--------
K
K
L
W
T
D
----
G
A
D
G
E
P
I
S
L
Y
C
A
F
N
E
L
D
E
----------------------------
A
R
F
V
V
N
R
I
K
T
W
Q
D
N
G
-
G
------
A
L
------
A
-----------------
E
C
A
I
L
Y
R
S
-
N
A
Q
S
R
V
L
E
E
A
L
L
Q
A
S
M
P
--
Y
R
---
I
---
Y
G
G
M
R
F
F
E
R
Q
E
I
K
D
A
L
S
Y
L
R
L
I
V
N
--
R
N
D
D
A
A
F
---
E
R
V
V
N
T
P
TRG
I
G
D
R
T
L
D
V
V
--------------
R
Q
T
S
-
R
D
R
QLT
L
W
Q
A
C
R
E
L
L
Q
--
E
K
A
L
A
----
G
R
A
A
S
A
L
Q
R
----------
F
------
M
------------
E
-------------
L
I
D
A
L
A
Q
E
T
A
D
-------
M
P
L
H
V
Q
T
D
R
V
I
K
D
S
G
L
-
R
--
T
-
M
-
Y
-
E
Q
E
K
G
E
----
K
--
G
-
Q
-
T
R
---
I
E
N
L
E
E
L
V
T
A
T
R
Q
F
S
Y
-------
N
-----EDLM
P
-
L
---------------
Q
A
F
L
---
S
H
A
A
--
L
-------
E
A
-------
G
E
G
-
Q
A
-------
D
--
T
W
Q
------
D
A
V
Q
L
M
T
L
H
S
A
K
G
L
E
F
P
Q
V
F
I
V
----
G
M
-----
E
---
E
G
---------
M
F
P
S
Q
----
M
S
L
D
---
E
---
G
G
-----------------------------------
R
L
E
---
E
E
R
R
L
-
A
Y
V
G
V
T
R
A
M
Q
K
L
T
---
L
--------
T
------------
Y
A
E
T
R
---------
R
-------------------------
L
Y
G
--------
K
E
V
Y
H
R
P
S
R
F
-
I
G
E
----------
L
P
E
E
C
V
E
E
V
R
L
R
A
---
T
V
S
R
--
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
63.29
21%
-72
- C4 -
3LFU
2
UVRD_ECOLI
A:
[172-612]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
Y
-
Q
A
Y
Q
E
A
C
D
R
---
A
G
L
V
D
F
A
E
L
L
L
R
A
H
E
L
W
L
N
-
K
P
H
-----------
I
L
Q
H
Y
R
E
R
F
T
N
I
L
-
V
D
E
F
Q
D
T
N
N
I
Q
Y
A
W
I
R
L
L
A
G
D
-------
T
G
K
V
M
I
V
G
D
D
D
Q
S
I
Y
G
W
R
G
A
Q
----
V
E
N
I
Q
R
F
L
N
D
F
P
G
A
E
---
T
I
R
L
E
Q
N
Y
R
S
T
S
N
I
L
S
A
A
N
A
L
I
E
N
N
N
G
R
L
G
--------
K
K
L
W
T
D
----
G
A
D
G
E
P
I
S
L
Y
C
A
F
N
E
L
D
E
----------------------------
A
R
F
V
V
N
R
I
K
T
W
Q
D
N
G
-
G
------
A
L
------
A
-----------------
E
C
A
I
L
Y
R
S
-
N
A
Q
S
R
V
L
E
E
A
L
L
Q
A
S
M
P
--
Y
R
---
I
---
Y
G
G
M
R
F
F
E
R
Q
E
I
K
D
A
L
S
Y
L
R
L
I
A
N
--
R
N
D
D
A
A
F
---
E
R
V
V
N
T
P
TRG
I
G
D
R
T
L
D
V
V
--------------
R
Q
T
S
-
R
D
R
QLT
L
W
Q
A
C
R
E
L
L
Q
--
E
K
A
L
A
----
G
R
A
A
S
A
L
Q
R
----------
F
------
M
------------
E
-------------
L
I
D
A
L
A
Q
E
T
A
D
-------
M
P
L
H
V
Q
T
D
R
V
I
K
D
S
G
L
-
R
--
T
-
M
-
Y
-
E
Q
E
K
G
E
----
K
--
G
-
Q
-
T
R
---
I
E
N
L
E
E
L
V
T
A
T
R
Q
F
S
--------------EDLM
P
-
L
---------------
Q
A
F
L
---
S
H
A
A
--
L
-------
E
--------
G
E
G
-
Q
A
-------
D
--
T
W
Q
------
D
A
V
Q
L
M
T
L
H
S
A
K
G
L
E
F
P
Q
V
F
I
V
----
G
M
-----
E
---
E
G
---------
M
F
P
S
Q
----
M
S
L
--------
G
G
-----------------------------------
R
L
E
---
E
E
R
R
L
-
A
Y
V
G
V
T
R
A
M
Q
K
L
T
---
L
--------
T
------------
Y
A
E
T
R
---------
R
-------------------------
L
Y
G
--------
K
E
V
Y
H
R
P
S
R
F
-
I
G
E
----------
L
P
E
E
C
V
E
E
V
R
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
63.22
21%
-68
- C4 -
2IS6
6
UVRD_ECOLI
A:
[172-612]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
Y
-
Q
A
Y
Q
E
A
C
D
R
---
A
G
L
V
D
F
A
E
L
L
L
R
A
H
E
L
W
L
N
------
K
P
------
H
I
L
Q
H
Y
R
E
R
F
T
N
I
L
-
V
D
E
F
Q
D
T
N
N
I
Q
Y
A
W
I
R
L
L
A
G
D
-------
T
G
K
V
M
I
V
G
D
D
D
Q
S
I
Y
G
W
R
G
A
Q
----
V
E
N
I
Q
R
F
L
N
D
F
P
G
A
E
---
T
I
R
L
E
Q
N
Y
R
S
T
S
N
I
L
S
A
A
N
A
L
I
E
N
N
N
G
R
L
G
--------
K
K
L
W
T
D
----
G
A
D
G
E
P
I
S
L
Y
C
A
F
N
E
L
D
E
----------------------------
A
R
F
V
V
N
R
I
K
T
W
Q
D
N
G
-
G
------
A
L
------
A
-----------------
E
C
A
I
L
Y
R
S
-
N
A
Q
S
R
V
L
E
E
A
L
L
Q
A
S
M
P
--
Y
R
---
I
---
Y
G
G
M
R
F
F
E
R
Q
E
I
K
D
A
L
S
Y
L
R
L
I
V
N
--
R
N
D
D
A
A
F
---
E
R
V
V
N
T
P
TRG
I
G
D
R
T
L
D
V
V
--------------
R
Q
T
S
-
R
D
R
QLT
L
W
Q
A
C
R
E
L
L
Q
--
E
K
A
L
A
----
G
R
A
A
S
A
L
Q
R
----------
F
------
M
------------
E
-------------
L
I
D
A
L
A
Q
E
T
A
D
-------
M
P
L
H
V
Q
T
D
R
V
I
K
D
S
G
L
-
R
--
T
-
M
-
Y
-
E
Q
E
K
G
E
----
K
--
G
-
Q
-
T
R
---
I
E
N
L
E
E
L
V
T
A
T
R
Q
F
S
Y
-------
N
----
E
EDLM
P
-
L
---------------
Q
A
F
L
---
S
H
A
A
--
L
-------
E
A
-------
G
E
G
-
Q
A
-------
D
--
T
W
Q
------
D
A
V
Q
L
M
T
L
H
S
A
K
G
L
E
F
P
Q
V
F
I
V
----
G
M
-----
E
---
E
G
---------
M
F
P
S
Q
----
M
S
L
D
---
E
---
G
G
-----------------------------------
R
L
E
---
E
E
R
R
L
-
A
Y
V
G
V
T
R
A
M
Q
K
L
T
---
L
--------
T
------------
Y
A
E
T
R
---------
R
-------------------------
L
Y
G
--------
K
E
V
Y
H
R
P
S
R
F
-
I
G
E
----------
L
P
E
E
C
V
E
E
V
R
L
R
A
---
T
V
S
R
--
P
V
S
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
62.44
22%
-57
- C4 -
4C2U
6
?
A:
[188-663]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
G
Q
---
N
A
I
-
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
------
V
P
------
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
-
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
-------
D
R
N
L
L
V
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
-------
P
D
A
K
V
Y
M
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
N
T
E
R
L
-----
D
K
T
L
K
P
V
---------------------------
K
E
A
G
Q
P
V
T
F
H
R
A
-------
T
D
--
H
---
R
A
E
G
D
Y
V
A
D
W
L
T
------------------------
R
--
L
H
G
E
G
R
AWS
E
M
A
I
L
Y
R
T
-
N
A
Q
S
R
V
I
E
E
S
L
R
R
V
Q
I
P
A
R
I
V
---
G
---
G
V
G
F
--
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
--
P
A
D
D
V
A
L
---
R
R
I
I
G
R
P
---
R
R
G
I
G
D
T
A
L
Q
K
L
M
E
W
A
R
T
H
HTS
V
L
T
A
C
-
A
N
A
------------
A
--
E
Q
N
I
L
----
D
R
----
G
A
H
----------
K
------
A
------------
T
-------------
E
F
A
G
L
M
E
A
M
S
E
-------
A
A
-
D
N
Y
E
P
A
A
F
L
R
F
V
M
-
E
--
T
S
G
-
Y
-
L
D
L
L
R
Q
----
E
--
G
-
Q
-
E
G
---
Q
V
R
L
E
N
L
E
E
L
V
S
A
A
E
E
-------
W
----
S
------
Q
DEANVGGS
I
A
D
F
L
D
D
A
A
L
L
---
S
S
V
D
--
D
-------
M
R
-------
T
K
A
-
E
N
-------
K
G
A
P
E
-------
D
A
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
V
F
I
V
----
G
V
------------------------
E
---
Q
G
L
L
P
---
S
---
K
G
A
-
I
---
A
E
G
P
-
S
---
G
--------------
I
E
E
E
R
---------
R
L
-
F
Y
V
G
I
T
R
A
M
E
R
L
L
---
M
T
A
A
Q
N
R
M
Q
F
------------
G
K
T
N
A
---------
A
-------------------------
E
D
S
A
F
L
E
D
I
EG
L
F
D
T
V
D
P
Y
G
Q
-
P
I
E
----------
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------