@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0179: (2015-11-29 )
MKKISVLGSTGSIGKKTVDLLLKRKEEYQVEALSTCSNFALLACQAKLLNARYVAISNKRFYKDLKESLLGTGIKVEVGTEGLMNVASLPVDLSVVAVVGIAGLEPVMHVIESGTKVIALANKESIVCGGKLLLKKTEEKNVQIVPIDSEHNAIFQVLQNGNKCVEKIILTASGGSFLNYSLEQLRNVTVGQALSHPTWNMGKKISVDSATMMNKALEIIEAHNLFNISPNRIEAIVHPESIIHGIVIYKDGFNFAVLAEADMAIPISYALSWPERSALSYKLDLTKQKLTFQEPDHKRFPALKLSMEVLNSSSPHTNSIVLNAANEVAVDKFLKSRIDFLEIIKVVKLTVENFDSYTDINSLSDIINIDLESRAIAKEIIKNKVLAYS
Atome Classification :
(75 SA)
.........10........20.---.......30.....-...40........50........60........70--....-----...--.80...-..-...-90.........100.......110.......120.......130......-.140.......150......--------------.160---.-----------.-.-..----------...170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270....-.-..280-...-.-.-..290.......300......--.310.......320.......330.......340.......350......-.360.......370.....-..380.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
K
I
S
V
LGSTGSI
G
K
K
T
V
D
L
L
L
---KR
K
E
E
Y
Q
V
E
A
L
S
T
C
-
S
N
F
A
L
L
A
C
Q
A
K
LLN
A
R
Y
V
A
IS
N
K
R
F
Y
K
D
L
K
E
S
L
LG--T
G
I
K
-----
V
E
V--GTEG
L
M
-
N
V
-ASL-P-V
D
L
S
V
V
A
V
VGIA
G
L
E
P
V
M
H
V
I
ESG
T
K
V
I
A
LANK
E
S
I
VCG
G
K
L
L
L
K
KTE-EK
N
V
Q
I
V
P
IDSE
H
N
A
I
F
Q
V
L
--------------QN
G
----
N
-----------
K
-
C
-
V
E
----------
K
I
I
L
TASGG
S
F
L
N
Y
S
L
E
Q
L
RNVTVGQALSHPTWNMG
K
K
ISV
D
S
A
T
M
M
N
K
A
L
E
I
I
E
AHNLFNISPN
R
I
E
A
I
V
H
P
E
S
I
I
H
G
I
V
I
Y
KDGF
N
F
A
V
L
AEA
D
M
A
I
P
I
S
Y
ALSWPER-S-
A
L
S
Y
K
-
L
DL-T-K-QKLTFQEPDHKRF
P
A
L
K
L
S
M
E
--
V
LNSSSPHT
N
S
I
V
L
NA
A
N
E
V
A
V
D
K
F
L
K
S
R
I
D
F
L
E
I
I
K
V
V
K
L
T
V
ENFDSYT-D
I
N
S
L
S
D
I
INID
L
E
S
R
A
I
A
-
K
E
I
I
KNKVLAYS
103
HHSearch
96.12
43%
-105
- C4 -
1R0K
1
DXR_ZYMMO
A:
[4-386]
P
R
T
V
T
V
L
G
A
T
G
S
I
G
H
S
T
L
D
L
I
E
---
R
N
L
D
R
Y
Q
V
I
A
L
T
A
N
-
R
N
V
K
D
L
A
D
A
A
K
R
T
N
A
K
R
A
V
I
A
D
P
S
L
Y
N
D
L
K
E
A
L
A
G
--
S
S
V
E
-----
A
A
A
--
G
A
D
A
L
V
E
A
--
A
M
M
-
G
-
A
D
W
T
M
A
A
I
I
G
C
A
G
L
K
A
T
L
A
A
I
R
K
G
K
-
T
V
A
L
A
N
K
E
S
L
V
S
A
G
G
L
M
I
D
A
V
R
-
E
H
G
T
T
L
L
P
V
D
S
E
H
N
A
I
F
Q
C
F
--------------
P
H
H
----
N
R----------
D
-
Y
-
V
R
----------
R
I
I
I
T
A
S
G
G
P
F
R
T
T
S
L
A
E
M
A
T
V
T
P
E
R
A
V
Q
------
G
A
K
I
S
I
D
S
A
T
M
M
N
K
G
L
E
L
I
E
A
F
H
L
F
Q
I
P
L
E
K
F
E
I
L
V
H
P
Q
S
V
I
H
S
M
V
E
Y
L
D
G
S
I
L
A
Q
I
G
S
P
D
M
R
T
P
I
G
H
T
L
A
W
P
K
R
-
M
E
T
P
A
E
S
-
L
D
F
-
T
K
L
-
R
Q
M
D
F
E
A
P
D
Y
E
R
F
P
A
L
T
L
A
M
E
--
S
I
K
S
G
G
--
A
R
P
A
V
M
N
A
A
N
E
I
A
V
A
A
F
L
D
K
K
I
G
F
L
D
I
A
K
I
V
E
K
T
L
D
H
Y
T
P
A
T
--
P
S
S
L
E
D
V
F
A
I
D
N
E
A
R
I
Q
A
-
A
A
L
M
E
S
L
P
----
38
PsiBlast_CBE
95.39
40%
-105
- C4 -
1T1R
2
DXR_ECOLI
B:
[2-395]
-
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
---
H
N
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
--
Q
G
S
R
-----
T
E
V
LS
G
Q
Q
A
A
C
-
D
M
-
A
A
L
-
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
-
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
PQPIQHNLGYADLE
Q
N
G
--------------------
V
V
----------
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
-
V
-
N
S
G
V
K
P
L
D
F
-
C
-
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
--
A
F
E
Q
G
--
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
-
M
R
-
E
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S
----
37
PsiBlast_CBE
94.85
40%
-104
- C4 -
1T1S
2
DXR_ECOLI
B:
[2-395]
-
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
---
H
N
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
--
Q
G
S
R
-----
T
E
V
LS
G
Q
Q
A
A
C
-
D
M
-
A
A
L
-
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
-
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
PQPIQHNLGYADLE
Q
N
G
--------------------
V
V
----------
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
-
V
-
N
S
G
V
K
P
L
D
F
-
C
-
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
--
A
F
E
Q
G
--
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
-
M
R
-
E
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S
----
35
PsiBlast_CBE
94.85
40%
-103
- C4 -
3ANL
2
DXR_ECOLI
B:
[12-405]
-
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
---
H
N
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
--
Q
G
S
R
-----
T
E
V
LS
G
Q
Q
A
A
C
-
D
M
-
A
A
L
-
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
-
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
PQPIQHNLGYADLE
Q
N
G
--------------------
V
V
----------
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
-
V
-
N
S
G
V
K
P
L
D
F
-
C
-
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
--
A
F
E
Q
G
--
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
-
M
R
-
E
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S
----
26
PsiBlast_CBE
94.74
42%
-104
- C4 -
1R0K
1
DXR_ZYMMO
B:
[5-385]
-
R
T
V
T
V
L
G
A
T
G
S
I
G
H
S
T
L
D
L
I
E
---
R
N
L
D
R
Y
Q
V
I
A
L
T
A
N
-
R
N
V
K
D
L
A
D
A
A
K
R
T
N
A
K
R
A
V
I
A
D
P
S
L
Y
N
D
L
K
E
A
L
A
G
--
S
S
V
E
-----
A
A
A
--
G
A
D
A
L
V
-
E
A
-
A
M
M
-
G
-
A
D
W
T
M
A
A
I
I
G
C
A
G
L
K
A
T
L
A
A
I
R
K
G
-
K
T
V
A
L
A
N
K
E
S
L
V
S
A
G
G
L
M
I
D
A
V
R
-
E
H
G
T
T
L
L
P
V
D
S
E
H
N
A
I
F
Q
C
F
--------------
P
H
H
----
N
-----------
R
D
Y
-
V
R
----------
R
I
I
I
T
A
S
G
G
P
F
R
T
T
S
L
A
E
M
A
T
V
T
P
E
R
A
V
Q
H
P
--
S
M
G
A
K
I
S
I
D
S
A
T
M
M
N
K
G
L
E
L
I
E
A
F
H
L
F
Q
I
P
L
E
K
F
E
I
L
V
H
P
Q
S
V
I
H
S
M
V
E
Y
L
D
G
S
I
L
A
Q
I
G
S
P
D
M
R
T
P
I
G
H
T
L
A
W
P
K
R
M
E
-
T
P
A
E
S
-
L
D
F
-
T
-
K
L
R
Q
M
D
F
E
A
P
D
Y
E
R
F
P
A
L
T
L
A
M
E
--
S
I
K
S
G
G
--
A
R
P
A
V
M
N
A
A
N
E
I
A
V
A
A
F
L
D
K
K
I
G
F
L
D
I
A
K
I
V
E
K
T
L
D
H
Y
T
P
A
T
-
P
-
S
S
L
E
D
V
F
A
I
D
N
E
A
R
I
Q
A
-
A
A
L
M
E
S
L
-----
1
PsiBlast_PDB
94.68
42%
-104
- C4 -
1R0K
1
DXR_ZYMMO
A:
[5-385]
-
R
T
V
T
V
L
G
A
T
G
S
I
G
H
S
T
L
D
L
I
E
---
R
N
L
D
R
Y
Q
V
I
A
L
T
A
N
-
R
N
V
K
D
L
A
D
A
A
K
R
T
N
A
K
R
A
V
I
A
D
P
S
L
Y
N
D
L
K
E
A
L
A
G
--
S
S
V
E
-----
A
A
A
--
G
A
D
A
L
V
-
E
A
-
A
M
M
-
G
-
A
D
W
T
M
A
A
I
I
G
C
A
G
L
K
A
T
L
A
A
I
R
K
G
-
K
T
V
A
L
A
N
K
E
S
L
V
S
A
G
G
L
M
I
D
A
V
R
-
E
H
G
T
T
L
L
P
V
D
S
E
H
N
A
I
F
Q
C
F
--------------
P
H
H
----
N
-----------
R
D
Y
-
V
R
----------
R
I
I
I
T
A
S
G
G
P
F
R
T
T
S
L
A
E
M
A
T
V
T
P
E
R
A
V
Q
------
G
A
K
I
S
I
D
S
A
T
M
M
N
K
G
L
E
L
I
E
A
F
H
L
F
Q
I
P
L
E
K
F
E
I
L
V
H
P
Q
S
V
I
H
S
M
V
E
Y
L
D
G
S
I
L
A
Q
I
G
S
P
D
M
R
T
P
I
G
H
T
L
A
W
P
K
R
M
E
-
T
P
A
E
S
-
L
D
F
-
T
-
K
L
R
Q
M
D
F
E
A
P
D
Y
E
R
F
P
A
L
T
L
A
M
E
--
S
I
K
S
G
G
--
A
R
P
A
V
M
N
A
A
N
E
I
A
V
A
A
F
L
D
K
K
I
G
F
L
D
I
A
K
I
V
E
K
T
L
D
H
Y
T
P
A
T
-
P
-
S
S
L
E
D
V
F
A
I
D
N
E
A
R
I
Q
A
-
A
A
L
M
E
S
L
P
----
11
PsiBlast_PDB
94.61
40%
-108
- C4 -
3IIE
2
DXR_YERPY
A:
[4-396]
M
K
Q
L
T
I
L
G
S
T
G
S
I
G
N
S
T
L
S
V
V
R
---
A
N
P
E
L
F
K
V
T
A
L
V
A
G
-
R
N
V
R
E
M
A
Q
Q
C
L
E
F
S
P
R
Y
A
A
M
S
D
E
H
S
A
K
S
L
R
L
L
L
A
E
--
Q
G
S
D
-----
T
E
V
Y
S
G
E
T
A
A
C
-
E
L
-
A
A
L
-
D
D
V
D
Q
V
M
A
A
I
V
G
I
A
G
L
P
S
T
L
A
A
I
R
A
G
K
Q
V
L
-
L
A
N
K
E
S
L
I
T
C
G
K
L
F
M
D
E
V
K
-
R
S
R
A
Q
L
L
P
I
D
S
E
H
N
A
I
F
Q
S
L
P
E
R
I
Q
R
Q
LGYSSLN
E
N
G
--------------------
V
S
----------
R
I
I
L
T
G
S
G
G
P
F
R
E
T
P
L
S
Q
F
S
D
V
T
P
D
Q
A
---------
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
E
Q
I
E
V
V
L
H
P
Q
S
V
I
H
S
M
V
R
Y
H
D
G
S
I
L
A
Q
M
G
T
P
D
M
R
T
P
I
A
H
A
M
A
Y
P
M
R
V
S
-
S
G
V
A
P
-
L
D
F
-
C
-
K
V
G
A
L
T
F
T
T
P
D
Y
Q
R
Y
P
C
L
K
L
A
I
D
--
A
C
N
A
G
--
Q
A
A
T
T
A
L
N
A
A
N
E
I
S
V
M
A
F
L
D
S
K
I
R
F
T
D
I
E
V
I
N
R
T
V
V
E
G
L
-
L
L
S
-
E
P
T
S
V
E
E
V
L
V
I
D
R
K
A
R
D
V
A
-
A
Q
V
I
A
K
------
2
PsiBlast_PDB
94.59
42%
-103
- C4 -
1R0L
1
DXR_ZYMMO
A:
[5-385]
-
R
T
V
T
V
L
G
A
T
G
S
I
G
H
S
T
L
D
L
I
E
---
R
N
L
D
R
Y
Q
V
I
A
L
T
A
N
-
R
N
V
K
D
L
A
D
A
A
K
R
T
N
A
K
R
A
V
I
A
D
P
S
L
Y
N
D
L
K
E
A
L
A
G
--
S
S
V
E
-----
A
A
A
--
G
A
D
A
L
V
-
E
A
-
A
M
M
-
G
-
A
D
W
T
M
A
A
I
I
G
C
A
G
L
K
A
T
L
A
A
I
R
K
G
-
K
T
V
A
L
A
N
K
E
S
L
V
S
A
G
G
L
M
I
D
A
V
R
-
E
H
G
T
T
L
L
P
V
D
S
E
H
N
A
I
F
Q
C
F
--------------
P
H
H
----
N
-----------
R
D
Y
-
V
R
----------
R
I
I
I
T
A
S
G
G
P
F
R
T
T
S
L
A
E
M
A
T
V
T
P
E
R
A
V
Q
------
G
A
K
I
S
I
D
S
A
T
M
M
N
K
G
L
E
L
I
E
A
F
H
L
F
Q
I
P
L
E
K
F
E
I
L
V
H
P
Q
S
V
I
H
S
M
V
E
Y
L
D
G
S
I
L
A
Q
I
G
S
P
D
M
R
T
P
I
G
H
T
L
A
W
P
K
R
M
E
-
T
P
A
E
S
-
L
D
F
-
T
-
K
L
R
Q
M
D
F
E
A
P
D
Y
E
R
F
P
A
L
T
L
A
M
E
--
S
I
K
S
G
G
--
A
R
P
A
V
M
N
A
A
N
E
I
A
V
A
A
F
L
D
K
K
I
G
F
L
D
I
A
K
I
V
E
K
T
L
D
H
Y
T
P
A
T
-
P
-
S
S
L
E
D
V
F
A
I
D
N
E
A
R
I
Q
A
-
A
A
L
M
E
S
L
-----
13
PsiBlast_PDB
94.53
40%
-104
- C4 -
3ANM
2
DXR_ECOLI
A:
[12-405]
-
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
---
H
N
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
--
Q
G
S
R
-----
T
E
V
L
S
G
Q
Q
A
A
C
-
D
M
-
A
A
L
-
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
-
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
N
LGYADLE
Q
N
G
--------------------
V
V
----------
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
-
V
-
N
S
G
V
K
P
L
D
F
-
C
-
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
--
A
F
E
Q
G
--
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
-
M
R
-
E
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S
S
A
--
34
PsiBlast_CBE
94.38
40%
-105
- C4 -
3ANM
2
DXR_ECOLI
B:
[12-405]
-
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
---
H
N
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
--
Q
G
S
R
-----
T
E
V
LS
G
Q
Q
A
A
C
-
D
M
-
A
A
L
-
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
-
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
PQPIQHNLGYADLE
Q
N
G
--------------------
V
V
----------
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
-
V
-
N
S
G
V
K
P
L
D
F
-
C
-
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
--
A
F
E
Q
G
--
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
-
M
R
-
E
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S
----
14
PsiBlast_PDB
94.34
40%
-106
- C4 -
3ANN
2
DXR_ECOLI
A:
[12-405]
-
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
---
H
N
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
--
Q
G
S
R
-----
T
E
V
L
S
G
Q
Q
A
A
C
-
D
M
-
A
A
L
-
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
-
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
N
LGYADLE
Q
N
G
--------------------
V
V
----------
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
-
V
-
N
S
G
V
K
P
L
D
F
-
C
-
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
--
A
F
E
Q
G
--
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
-
M
R
-
E
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S
S
A
--
28
PsiBlast_CBE
94.31
40%
-111
- C4 -
3R0I
2
DXR_ECOLI
B:
[13-407]
M
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
---
H
N
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
--
Q
G
S
R
-----
T
E
V
LS
G
Q
Q
A
A
C
-
D
M
-
A
A
L
-
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
-
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
PQPIQHNLGYADLE
Q
N
G
--------------------
V
V
----------
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
-----
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
-
V
-
N
S
G
V
K
P
L
D
F
-
C
-
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
--
A
F
E
Q
G
--
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
-
M
R
-
E
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S
----
4
PsiBlast_PDB
94.18
40%
-111
- C4 -
3R0I
2
DXR_ECOLI
A:
[13-407]
M
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
---
H
N
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
--
Q
G
S
R
-----
T
E
V
L
S
G
Q
Q
A
A
C
-
D
M
-
A
A
L
-
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
-
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
N
LGYADLE
Q
N
G
--------------------
V
V
----------
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
-----
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
-
V
-
N
S
G
V
K
P
L
D
F
-
C
-
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
--
A
F
E
Q
G
--
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
-
M
R
-
E
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S
----
12
PsiBlast_PDB
94.16
40%
-106
- C4 -
3ANL
2
DXR_ECOLI
A:
[12-405]
-
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
---
H
N
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
--
Q
G
S
R
-----
T
E
V
L
S
G
Q
Q
A
A
C
-
D
M
-
A
A
L
-
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
-
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
N
LGYADLE
Q
N
G
--------------------
V
V
----------
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
-
V
-
N
S
G
V
K
P
L
D
F
-
C
-
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
--
A
F
E
Q
G
--
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
-
M
R
-
E
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S
S
A
--
15
PsiBlast_PDB
94.12
40%
-103
- C4 -
2EGH
3
DXR_ECOLI
A:
[12-405]
-
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
---
H
N
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
--
Q
G
S
R
-----
T
E
V
L
S
G
Q
Q
A
A
C
-
D
M
-
A
A
L
-
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
-
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
N
LGYADLE
Q
N
G
--------------------
V
V
----------
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
-
V
-
N
S
G
V
K
P
L
D
F
-
C
-
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
--
A
F
E
Q
G
--
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
-
M
R
-
E
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S
S
A
--
33
PsiBlast_CBE
93.93
40%
-104
- C4 -
3ANN
2
DXR_ECOLI
B:
[12-405]
-
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
---
H
N
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
--
Q
G
S
R
-----
T
E
V
LS
G
Q
Q
A
A
C
-
D
M
-
A
A
L
-
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
-
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
PQPIQHNLGYADLE
Q
N
G
--------------------
V
V
----------
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
-
V
-
N
S
G
V
K
P
L
D
F
-
C
-
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
--
A
F
E
Q
G
--
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
-
M
R
-
E
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S
----
36
PsiBlast_CBE
93.83
40%
-102
- C4 -
2EGH
3
DXR_ECOLI
B:
[12-405]
-
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
---
H
N
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
--
Q
G
S
R
-----
T
E
V
LS
G
Q
Q
A
A
C
-
D
M
-
A
A
L
-
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
-
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
PQPIQHNLGYADLE
Q
N
G
--------------------
V
V
----------
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
-
V
-
N
S
G
V
K
P
L
D
F
-
C
-
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
--
A
F
E
Q
G
--
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
-
M
R
-
E
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S
----
24
PsiBlast_CBE
93.67
42%
-105
- C4 -
1R0K
1
DXR_ZYMMO
D:
[5-385]
-
R
T
V
T
V
L
G
A
T
G
S
I
G
H
S
T
L
D
L
I
E
---
R
N
L
D
R
Y
Q
V
I
A
L
T
A
N
-
R
N
V
K
D
L
A
D
A
A
K
R
T
N
A
K
R
A
V
I
A
D
P
S
L
Y
N
D
L
K
E
A
L
A
G
--
S
S
V
E
-----
A
A
A
--
G
A
D
A
L
V
-
E
A
-
A
M
M
-
G
-
A
D
W
T
M
A
A
I
I
G
C
A
G
L
K
A
T
L
A
A
I
R
K
G
-
K
T
V
A
L
A
N
K
E
S
L
V
S
A
G
G
L
M
I
D
A
V
R
-
E
H
G
T
T
L
L
P
V
D
S
E
H
N
A
I
F
Q
C
F
--------------
P
H
H
----
N
-----------
R
D
Y
-
V
R
----------
R
I
I
I
T
A
S
G
G
P
F
R
T
T
S
L
A
E
M
A
T
V
T
P
E
R
A
V
Q
H
P
---
M
G
A
K
I
S
I
D
S
A
T
M
M
N
K
G
L
E
L
I
E
A
F
H
L
F
Q
I
P
L
E
K
F
E
I
L
V
H
P
Q
S
V
I
H
S
M
V
E
Y
L
D
G
S
I
L
A
Q
I
G
S
P
D
M
R
T
P
I
G
H
T
L
A
W
P
K
R
M
E
-
T
P
A
E
S
-
L
D
F
-
T
-
K
L
R
Q
M
D
F
E
A
P
D
Y
E
R
F
P
A
L
T
L
A
M
E
--
S
I
K
S
G
G
--
A
R
P
A
V
M
N
A
A
N
E
I
A
V
A
A
F
L
D
K
K
I
G
F
L
D
I
A
K
I
V
E
K
T
L
D
H
Y
T
P
A
T
-
P
-
S
S
L
E
D
V
F
A
I
D
N
E
A
R
I
Q
A
-
A
A
L
M
E
S
------
16
PsiBlast_PDB
93.60
40%
-103
- C4 -
1T1R
2
DXR_ECOLI
A:
[2-395]
-
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
---
H
N
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
--
Q
G
S
R
-----
T
E
V
L
S
G
Q
Q
A
A
C
-
D
M
-
A
A
L
-
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
-
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
N
LGYADLE
Q
N
G
--------------------
V
V
----------
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
-
V
-
N
S
G
V
K
P
L
D
F
-
C
-
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
--
A
F
E
Q
G
--
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
-
M
R
-
E
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S
----
29
PsiBlast_CBE
92.96
40%
-101
- C4 -
1Q0Q
2
DXR_ECOLI
B:
[9-403]
M
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
---
H
N
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
--
Q
G
S
R
-----
T
E
V
LS
G
Q
Q
A
A
C
-
D
M
-
A
A
L
-
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
-
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
PQPIQHNLGYADLE
Q
N
G
--------------------
V
V
----------
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
-
V
-
N
S
G
V
K
P
L
D
F
-
C
-
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
--
A
F
E
Q
G
--
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
-
M
R
-
E
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S
----
6
PsiBlast_PDB
92.64
40%
-100
- C4 -
1Q0Q
2
DXR_ECOLI
A:
[9-403]
M
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
---
H
N
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
--
Q
G
S
R
-----
T
E
V
L
S
G
Q
Q
A
A
C
-
D
M
-
A
A
L
-
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
-
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
N
LGYADLE
Q
N
G
--------------------
V
V
----------
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
-
V
-
N
S
G
V
K
P
L
D
F
-
C
-
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
--
A
F
E
Q
G
--
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
-
M
R
-
E
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S
----
17
PsiBlast_PDB
92.50
40%
-104
- C4 -
1T1S
3
DXR_ECOLI
A:
[2-395]
-
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
---
H
N
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
--
Q
G
S
R
-----
T
E
V
L
S
G
Q
Q
A
A
C
-
D
M
-
A
A
L
-
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
-
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
N
LGYADLE
Q
N
G
--------------------
V
V
----------
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
-
V
-
N
S
G
V
K
P
L
D
F
-
C
-
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
--
A
F
E
Q
G
--
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
-
M
R
-
E
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S
----
10
PsiBlast_PDB
92.45
40%
-104
- C4 -
1ONP
2
DXR_ECOLI
A:
[1-395]
M
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
---
H
N
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
--
Q
G
S
R
-----
T
E
V
L
S
G
Q
Q
A
A
C
-
D
M
-
A
A
L
-
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
-
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
N
LGYADLE
Q
N
G
--------------------
V
V
----------
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
-
V
-
N
S
G
V
K
P
L
D
F
-
C
-
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
--
A
F
E
Q
G
--
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
-
M
R
-
E
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
-----
30
PsiBlast_CBE
92.30
40%
-102
- C4 -
1ONP
2
DXR_ECOLI
B:
[1-395]
M
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
---
H
N
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
--
Q
G
S
R
-----
T
E
V
LS
G
Q
Q
A
A
C
-
D
M
-
A
A
L
-
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
-
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
PQPIQHNLGYADLE
Q
N
G
--------------------
V
V
----------
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
-
V
-
N
S
G
V
K
P
L
D
F
-
C
-
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
--
A
F
E
Q
G
--
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
-
M
R
-
E
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
-----
5
PsiBlast_PDB
91.79
40%
-98
- C4 -
1Q0L
2
DXR_ECOLI
A:
[9-403]
M
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
---
H
N
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
--
Q
G
S
R
-----
T
E
V
L
S
G
Q
Q
A
A
C
-
D
M
-
A
A
L
-
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
-
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
N
LGYADLE
Q
N
G
--------------------
V
V
----------
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
-
V
-
N
S
G
V
K
P
L
D
F
-
C
-
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
--
A
F
E
Q
G
--
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
-
M
R
-
E
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S
----
101
HHSearch
91.42
40%
-94
- C4 -
1Q0Q
2
DXR_ECOLI
A:
[9-404]
M
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
---
H
N
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
Q
G
S
R
T
E
-----
V
L
S
--
G
Q
Q
A
A
C
D
M
A
-
A
L
E
-
D
-
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
K
-
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
--------------
P
Q
P
----
I
Q
H
N
LGYADLEQ
N
-
G
-
V
V
----------
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
-
V
N
S
G
V
K
P
-
L
D
F
-
C
K
L
-
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
--
A
F
E
Q
G
Q
--
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
--
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
-
R
K
E
V
M
R
L
A
S
---
20
PsiBlast_PDB
91.36
38%
-102
- C4 -
1Q0H
3
DXR_ECOLI
A:
[10-399]
-
K
Q
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
---
H
N
P
E
H
F
R
V
V
A
L
V
A
G
-
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
--
Q
G
S
R
-----
T
E
V
L
S
G
Q
Q
A
A
C
-
D
M
-
A
A
L
-
E
D
V
D
Q
V
M
A
A
I
V
G
A
A
G
L
L
P
T
L
A
A
I
R
A
G
-
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
R
L
F
M
D
A
V
K
-
Q
S
K
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
L
P
Q
P
I
Q
H
N
LGYADLE
Q
N
G
--------------------
V
V
----------
S
I
L
L
T
G
S
G
G
P
F
R
E
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
A
W
P
N
R
-
V
-
N
S
G
V
K
P
L
D
F
-
C
-
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
P
C
L
K
L
A
M
E
--
A
F
E
Q
G
--
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
--
E
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
-
R
K
E
V
M
R
L
A
S
---
42
PsiBlast_CBE
89.84
37%
-105
- C4 -
4Y6S
2
DXR_PLAF7
A:
[14-410]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
--
L
V
--
K
N
I
K
DYKPI
I
L
C
--
G
D
E
G
M
K
-
E
I
-
C
S
S
N
S
-
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
-
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------------
D
N
N
K
V
L
K
T
-----------
K
-
C
-
L
Q
DN
F
S
K
I
N
NIN
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
-
I
-
K
T
N
L
K
P
L
D
L
-
A
-
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
----
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
-
V
S
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
-
K
D
K
A
T
D
I
Y
N
K
H
N
67
PsiBlast_CBE
89.62
33%
-101
- C4 -
4A03
3
DXR_MYCTU
B:
[23-397]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
---
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
D
--------
I
P
-----
Y
H
G
--
S
D
A
A
T
R
-
L
V
-
E
Q
T
-
E
-
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
-
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
--
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------------
R
G
G
----
T
-----------
P
-
D
E
V
A
----------
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
-
G
A
A
A
A
-
C
D
F
H
T
-
A
-
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
--
A
G
V
A
G
G
C
M
T
--
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
-
Q
R
A
V
S
G
------
54
PsiBlast_CBE
89.55
37%
-100
- C4 -
3AUA
5
DXR_PLAFX
B:
[80-476]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
ECN
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
--
L
V
--
K
N
I
K
DYKPI
I
L
C
--
G
D
E
G
M
K
-
E
I
-
C
S
S
N
S
-
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
-
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------------
D
N
N
KVLK
T
-----------
K
-
C
-
L
Q
DNFSKINNIN
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
-
I
-
K
T
N
L
K
P
L
D
L
-
A
-
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
--
A
G
I
K
G
N
F
Y
--
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
-
V
S
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
-
K
D
K
A
T
D
I
Y
N
K
H
N
68
PsiBlast_CBE
88.73
33%
-102
- C4 -
4A03
4
DXR_MYCTU
A:
[23-397]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
---
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
D
--------
I
P
-----
Y
H
G
--
S
D
A
A
T
R
-
L
V
-
E
Q
T
-
E
-
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
-
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
--
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------------
R
G
G
----
T
-----------
P
-
D
E
V
A
----------
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
-
G
A
A
A
A
-
C
D
F
H
T
-
A
-
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
--
A
G
V
A
G
G
C
M
T
--
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
-
Q
R
A
V
S
G
------
65
PsiBlast_CBE
88.67
33%
-102
- C4 -
4AIC
3
DXR_MYCTU
B:
[23-397]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
---
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
D
--------
I
P
-----
Y
H
G
--
S
D
A
A
T
R
-
L
V
-
E
Q
T
-
E
-
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
-
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
--
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------------
R
G
G
----
T
-----------
P
-
D
E
V
A
----------
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
-
G
A
A
A
A
-
C
D
F
H
T
-
A
-
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
--
A
G
V
A
G
G
C
M
T
--
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
-
Q
R
A
V
S
G
M
-----
52
PsiBlast_CBE
88.63
37%
-101
- C4 -
3WQQ
5
DXR_PLAFX
B:
[80-476]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
ECN
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
--
L
V
--
K
N
I
K
DYKPI
I
L
C
--
G
D
E
G
M
K
-
E
I
-
C
S
S
N
S
-
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
-
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------------
D
N
N
KVLK
T
-----------
K
-
C
-
L
Q
DNFSKINNIN
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
-
I
-
K
T
N
L
K
P
L
D
L
-
A
-
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
--
A
G
I
K
G
N
F
Y
--
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
-
V
S
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
-
K
D
K
A
T
D
I
Y
N
K
H
N
100
PsiBlast_CBE
88.48
33%
-103
- C4 -
2JCX
2
DXR_MYCTU
B:
[23-397]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
---
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
D
--------
I
P
-----
Y
H
G
--
S
D
A
A
T
R
-
L
V
-
E
Q
T
-
E
-
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
-
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
--
Q
I
V
P
V
N
S
E
H
S
A
L
A
Q
C
L
--------------
R
G
G
----
T
-----------
P
-
D
E
V
A
----------
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
Q
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
-
G
A
A
A
A
-
C
D
F
H
T
-
A
-
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
--
A
G
V
A
G
G
C
M
T
--
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
-
Q
R
A
V
S
G
M
-----
57
PsiBlast_CBE
88.48
37%
-100
- C4 -
3AU9
4
DXR_PLAFX
A:
[80-476]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
--
L
V
--
K
N
I
K
DYKPI
I
L
C
--
G
D
E
G
M
K
-
E
I
-
C
S
S
N
S
-
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
-
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------------
D
N
N
K
V
L
K
T
-----------
K
-
C
-
L
Q
DN
F
S
K
I
N
NIN
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
-
I
-
K
T
N
L
K
P
L
D
L
-
A
-
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
--
A
G
I
K
G
N
F
Y
--
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
-
V
S
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
-
K
D
K
A
T
D
I
Y
N
K
H
N
43
PsiBlast_CBE
88.48
37%
-104
- C4 -
4Y6R
3
DXR_PLAF7
B:
[14-410]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
ECN
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
--
L
V
--
K
N
I
K
DYKPI
I
L
C
--
G
D
E
G
M
K
-
E
I
-
C
S
S
N
S
-
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
-
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------------
D
N
N
KVLK
T
-----------
K
-
C
-
L
Q
DNFSKINNIN
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
-
I
-
K
T
N
L
K
P
L
D
L
-
A
-
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
AG
I
K
G
N
F
Y
P
----
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
-
V
S
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
-
K
D
K
A
T
D
I
Y
N
K
H
N
51
PsiBlast_CBE
88.44
37%
-102
- C4 -
3WQR
4
DXR_PLAFX
A:
[80-476]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
--
L
V
--
K
N
I
K
DYKPI
I
L
C
--
G
D
E
G
M
K
-
E
I
-
C
S
S
N
S
-
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
-
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------------
D
N
N
K
V
L
K
T
-----------
K
-
C
-
L
Q
DN
F
S
K
I
N
NIN
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
-
I
-
K
T
N
L
K
P
L
D
L
-
A
-
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
--
A
G
I
K
G
N
F
Y
--
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
-
V
S
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
-
K
D
K
A
T
D
I
Y
N
K
H
N
53
PsiBlast_CBE
88.43
37%
-102
- C4 -
3WQQ
4
DXR_PLAFX
A:
[80-476]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
--
L
V
--
K
N
I
K
DYKPI
I
L
C
--
G
D
E
G
M
K
-
E
I
-
C
S
S
N
S
-
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
-
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------------
D
N
N
K
V
L
K
T
-----------
K
-
C
-
L
Q
DN
F
S
K
I
N
NIN
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
-
I
-
K
T
N
L
K
P
L
D
L
-
A
-
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
--
A
G
I
K
G
N
F
Y
--
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
-
V
S
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
-
K
D
K
A
T
D
I
Y
N
K
H
N
44
PsiBlast_CBE
88.40
37%
-102
- C4 -
4Y6R
3
DXR_PLAF7
A:
[14-410]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
--
L
V
--
K
N
I
K
DYKPI
I
L
C
--
G
D
E
G
M
K
-
E
I
-
C
S
S
N
S
-
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
-
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------------
D
N
N
K
V
L
K
T
-----------
K
-
C
-
L
Q
DN
F
S
K
I
N
NIN
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
-
I
-
K
T
N
L
K
P
L
D
L
-
A
-
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
----
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
-
V
S
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
-
K
D
K
A
T
D
I
Y
N
K
H
N
60
PsiBlast_CBE
88.39
37%
-102
- C4 -
4GAE
7
DXR_PLAFX
A:
[18-414]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
--
L
V
--
K
N
I
K
DYKPI
I
L
C
--
G
D
E
G
M
K
-
E
I
-
C
S
S
N
S
-
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
-
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------------
D
N
N
K
V
I
K
T
-----------
K
-
C
-
L
Q
DN
F
S
K
I
N
NIN
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
-
I
-
K
T
N
L
K
P
L
D
L
-
A
-
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
----
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
-
V
S
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
-
K
D
K
A
T
D
I
Y
N
K
H
N
55
PsiBlast_CBE
88.39
37%
-100
- C4 -
3AUA
4
DXR_PLAFX
A:
[80-476]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
--
L
V
--
K
N
I
K
DYKPI
I
L
C
--
G
D
E
G
M
K
-
E
I
-
C
S
S
N
S
-
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
-
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------------
D
N
N
K
V
L
K
T
-----------
K
-
C
-
L
Q
DN
F
S
K
I
N
NIN
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
-
I
-
K
T
N
L
K
P
L
D
L
-
A
-
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
--
A
G
I
K
G
N
F
Y
--
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
-
V
S
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
-
K
D
K
A
T
D
I
Y
N
K
H
N
88
PsiBlast_CBE
88.38
33%
-107
- C4 -
3ZI0
1
DXR_MYCTU
A:
[22-395]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
---
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
-------------------
I
P
-----
Y
H
G
--
S
D
A
A
T
R
-
L
V
-
E
Q
T
-
E
-
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
-
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
--
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------------
R
G
G
----
T
-----------
P
-
D
E
V
A
----------
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
--------
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
-
G
A
A
A
A
-
C
D
F
H
T
-
A
-
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
--
A
G
V
A
G
G
C
M
T
--
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
-
Q
R
A
V
S
-------
49
PsiBlast_CBE
88.33
37%
-100
- C4 -
3WQS
3
DXR_PLAFX
B:
[80-476]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
ECN
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
--
L
V
--
K
N
I
K
DYKPI
I
L
C
--
G
D
E
G
M
K
-
E
I
-
C
S
S
N
S
-
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
-
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------------
D
N
N
KVLK
T
-----------
K
-
C
-
L
Q
DNFSKINNIN
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
-
I
-
K
T
N
L
K
P
L
D
L
-
A
-
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
--
A
G
I
K
G
N
F
Y
--
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
-
V
S
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
-
K
D
K
A
T
D
I
Y
N
K
H
N
56
PsiBlast_CBE
88.21
37%
-100
- C4 -
3AU9
5
DXR_PLAFX
B:
[80-476]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
ECN
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
--
L
V
--
K
N
I
K
DYKPI
I
L
C
--
G
D
E
G
M
K
-
E
I
-
C
S
S
N
S
-
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
-
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------------
D
N
N
KVLK
T
-----------
K
-
C
-
L
Q
DNFSKINNIN
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
-
I
-
K
T
N
L
K
P
L
D
L
-
A
-
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
--
A
G
I
K
G
N
F
Y
--
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
-
V
S
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
-
K
D
K
A
T
D
I
Y
N
K
H
N
46
PsiBlast_CBE
88.17
37%
-102
- C4 -
4Y6P
3
DXR_PLAF7
A:
[14-410]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
--
L
V
--
K
N
I
K
DYKPI
I
L
C
--
G
D
E
G
M
K
-
E
I
-
C
S
S
N
S
-
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
-
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------------
D
N
N
K
V
L
K
T
-----------
K
-
C
-
L
Q
DN
F
S
K
I
N
NIN
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
-
I
-
K
T
N
L
K
P
L
D
L
-
A
-
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
----
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
-
V
S
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
-
K
D
K
A
T
D
I
Y
N
K
H
N
85
PsiBlast_CBE
88.13
33%
-102
- C4 -
2JCV
2
DXR_MYCTU
B:
[23-397]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
---
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
D
--------
I
P
-----
Y
H
G
--
S
D
A
A
T
R
-
L
V
-
E
Q
T
-
E
-
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
-
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
--
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------------
R
G
G
----
T
-----------
P
-
D
E
V
A
----------
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
-
G
A
A
A
A
-
C
D
F
H
T
-
A
-
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
--
A
G
V
A
G
G
C
M
T
--
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
-
Q
R
A
V
S
G
M
-----
47
PsiBlast_CBE
88.07
37%
-102
- C4 -
4Y67
2
DXR_PLAF7
B:
[14-410]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
ECN
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
--
L
V
--
K
N
I
K
DYKPI
I
L
C
--
G
D
E
G
M
K
-
E
I
-
C
S
S
N
S
-
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
-
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------------
D
N
N
KVLK
T
-----------
K
-
C
-
L
Q
DNFSKINNIN
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
-
I
-
K
T
N
L
K
P
L
D
L
-
A
-
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
AG
I
K
G
N
F
Y
P
----
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
-
V
S
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
-
K
D
K
A
T
D
I
Y
N
K
H
N
41
PsiBlast_CBE
88.05
37%
-100
- C4 -
4Y6S
2
DXR_PLAF7
B:
[14-410]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
ECN
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
--
L
V
--
K
N
I
K
DYKPI
I
L
C
--
G
D
E
G
M
K
-
E
I
-
C
S
S
N
S
-
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
-
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------------
D
N
N
KVLK
T
-----------
K
-
C
-
L
Q
DNFSKINNIN
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
-
I
-
K
T
N
L
K
P
L
D
L
-
A
-
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
AG
I
K
G
N
F
Y
P
----
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
-
V
S
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
-
K
D
K
A
T
D
I
Y
N
K
H
N
95
PsiBlast_CBE
88.04
33%
-101
- C4 -
4RCV
4
?
A:
[29-403]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
---
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
D
--------
I
P
-----
Y
H
G
--
S
D
A
A
T
R
-
L
V
-
E
Q
T
-
E
-
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
-
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
--
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------------
R
G
G
----
T
-----------
P
-
D
E
V
A
----------
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
--------
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
-
G
A
A
A
A
-
C
D
F
H
T
-
A
-
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
--
A
G
V
A
G
G
C
M
T
--
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
-
Q
R
A
V
S
G
M
-----
62
PsiBlast_CBE
87.99
37%
-103
- C4 -
4KP7
3
DXR_PLAFX
A:
[19-415]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
--
L
V
--
K
N
I
K
DYKPI
I
L
C
--
G
D
E
G
M
K
-
E
I
-
C
S
S
N
S
-
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
-
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------------
D
N
N
K
V
L
K
T
-----------
K
-
C
-
L
Q
DN
F
S
K
I
N
NIN
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
-
I
-
K
T
N
L
K
P
L
D
L
-
A
-
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
----
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
-
V
S
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
-
K
D
K
A
T
D
I
Y
N
K
H
-
73
PsiBlast_CBE
87.96
33%
-102
- C4 -
2Y1F
3
DXR_MYCTU
B:
[23-397]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
---
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
D
--------
I
P
-----
Y
H
G
--
S
D
A
A
T
R
-
L
V
-
E
Q
T
-
E
-
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
-
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
--
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------------
R
G
G
----
T
-----------
P
-
D
E
V
A
----------
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
-
G
A
A
A
A
-
C
D
F
H
T
-
A
-
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
--
A
G
V
A
G
G
C
M
T
--
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
-
Q
R
A
V
S
G
M
-----
59
PsiBlast_CBE
87.95
37%
-101
- C4 -
4GAE
9
DXR_PLAFX
B:
[18-414]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
--
L
V
--
K
N
I
K
D
Y
K
P
I
I
L
C
--
G
D
E
G
M
K
-
E
I
-
C
S
S
N
S
-
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
-
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------------
D
N
N
K
V
I
K
T
-----------
K
-
C
-
L
Q
DN
F
S
K
I
N
NIN
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
-
I
-
K
T
N
L
K
P
L
D
L
-
A
-
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
----
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
-
V
S
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
-
K
D
K
A
T
D
I
Y
N
K
H
N
48
PsiBlast_CBE
87.84
37%
-104
- C4 -
4Y67
2
DXR_PLAF7
A:
[14-410]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
--
L
V
--
K
N
I
K
DYKPI
I
L
C
--
G
D
E
G
M
K
-
E
I
-
C
S
S
N
S
-
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
-
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------------
D
N
N
K
V
L
K
T
-----------
K
-
C
-
L
Q
DN
F
S
K
I
N
NIN
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
-
I
-
K
T
N
L
K
P
L
D
L
-
A
-
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
----
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
-
V
S
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
-
K
D
K
A
T
D
I
Y
N
K
H
N
50
PsiBlast_CBE
87.72
37%
-101
- C4 -
3WQR
5
DXR_PLAFX
B:
[80-476]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
ECN
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
--
L
V
--
K
N
I
K
DYKPI
I
L
C
--
G
D
E
G
M
K
-
E
I
-
C
S
S
N
S
-
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
-
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------------
D
N
N
KVLK
T
-----------
K
-
C
-
L
Q
DNFSKINNIN
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
-
I
-
K
T
N
L
K
P
L
D
L
-
A
-
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
--
A
G
I
K
G
N
F
Y
--
P
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
-
V
S
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
-
K
D
K
A
T
D
I
Y
N
K
H
N
70
PsiBlast_CBE
87.68
33%
-100
- C4 -
3RAS
4
DXR_MYCTU
A:
[23-397]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
---
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
D
--------
I
P
-----
Y
H
G
--
S
D
A
A
T
R
-
L
V
-
E
Q
T
-
E
-
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
-
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
--
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------------
R
G
G
----
T
-----------
P
-
D
E
V
A
----------
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
-
G
A
A
A
A
-
C
D
F
H
T
-
A
-
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
--
A
G
V
A
G
G
C
M
T
--
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
-
Q
R
A
V
S
G
M
-----
84
PsiBlast_CBE
87.65
33%
-98
- C4 -
2JD1
4
DXR_MYCTU
A:
[23-397]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
---
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
D
--------
I
P
-----
Y
H
G
--
S
D
A
A
T
R
-
L
V
-
E
Q
T
-
E
-
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
-
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
--
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------------
R
G
G
----
T
-----------
P
-
D
E
V
A
----------
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
-
G
A
A
A
A
-
C
D
F
H
T
-
A
-
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
--
A
G
V
A
G
G
C
M
T
--
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
-
Q
R
A
V
S
G
M
-----
74
PsiBlast_CBE
87.48
33%
-102
- C4 -
2Y1F
4
DXR_MYCTU
A:
[23-397]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
---
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
D
--------
I
P
-----
Y
H
G
--
S
D
A
A
T
R
-
L
V
-
E
Q
T
-
E
-
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
-
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
--
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------------
R
G
G
----
T
-----------
P
-
D
E
V
A
----------
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
------
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
-
G
A
A
A
A
-
C
D
F
H
T
-
A
-
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
--
A
G
V
A
G
G
C
M
T
--
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
-
Q
R
A
V
S
G
M
-----
86
PsiBlast_CBE
87.37
33%
-98
- C4 -
2JCV
3
DXR_MYCTU
A:
[23-397]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
---
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
D
--------
I
P
-----
Y
H
G
--
S
D
A
A
T
R
-
L
V
-
E
Q
T
-
E
-
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
-
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
--
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------------
R
G
G
----
T
-----------
P
-
D
E
V
A
----------
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
-
G
A
A
A
A
-
C
D
F
H
T
-
A
-
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
--
A
G
V
A
G
G
C
M
T
--
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
-
Q
R
A
V
S
G
M
-----
45
PsiBlast_CBE
87.37
37%
-100
- C4 -
4Y6P
4
DXR_PLAF7
B:
[14-410]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
ECN
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
--
L
V
--
K
N
I
K
DYKPI
I
L
C
--
G
D
E
G
M
K
-
E
I
-
C
S
S
N
S
-
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
-
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------------
D
N
N
KVLK
T
-----------
K
-
C
-
L
Q
DNFSKINNIN
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
-
I
-
K
T
N
L
K
P
L
D
L
-
A
-
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
AG
I
K
G
N
F
Y
P
----
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
-
V
S
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
-
K
D
K
A
T
D
I
Y
N
K
H
N
97
PsiBlast_CBE
87.33
33%
-99
- C4 -
2JD0
3
DXR_MYCTU
A:
[23-397]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
---
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
D
--------
I
P
-----
Y
H
G
--
S
D
A
A
T
R
-
L
V
-
E
Q
T
-
E
-
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
-
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
--
Q
I
V
P
V
N
S
E
H
S
A
L
A
Q
C
L
--------------
R
G
G
----
T
-----------
P
-
D
E
V
A
----------
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
Q
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
-
G
A
A
A
A
-
C
D
F
H
T
-
A
-
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
--
A
G
V
A
G
G
C
M
T
--
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
-
Q
R
A
V
S
G
M
-----
61
PsiBlast_CBE
87.30
37%
-104
- C4 -
4KP7
2
DXR_PLAFX
B:
[19-415]
---
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
C
N
K
I
E
N
V
F
N
V
K
A
L
Y
V
N
-
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
K
E
--
L
V
--
K
N
I
K
DYKPI
I
L
C
--
G
D
E
G
M
K
-
E
I
-
C
S
S
N
S
-
I
D
K
I
V
I
G
I
D
S
F
Q
G
L
Y
S
T
M
Y
A
I
-
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
N
I
H
K
N
A
K
I
I
P
V
D
S
E
H
S
A
I
F
Q
C
L
--------------
D
N
N
K
V
L
K
T
-----------
K
-
C
-
L
Q
DN
F
S
K
I
N
NIN
K
I
F
L
C
S
S
G
G
P
F
Q
N
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
------
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
T
W
P
D
R
-
I
-
K
T
N
L
K
P
L
D
L
-
A
-
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
P
C
I
K
L
A
Y
Q
A
G
I
K
G
N
F
Y
P
----
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
-
V
S
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
-
K
D
K
A
T
D
I
Y
N
K
--
72
PsiBlast_CBE
87.04
33%
-99
- C4 -
2Y1G
4
DXR_MYCTU
A:
[23-397]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
---
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
D
--------
I
P
-----
Y
H
G
--
S
D
A
A
T
R
-
L
V
-
E
Q
T
-
E
-
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
-
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
--
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------------
R
G
G
----
T
-----------
P
-
D
E
V
A
----------
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
-----
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
-
G
A
A
A
A
-
C
D
F
H
T
-
A
-
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
--
A
G
V
A
G
G
C
M
T
--
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
-
Q
R
A
V
S
G
M
-----
91
PsiBlast_CBE
87.00
33%
-100
- C4 -
3ZHY
3
DXR_MYCTU
A:
[22-396]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
---
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
D
--------
I
P
-----
Y
H
G
--
S
D
A
A
T
R
-
L
V
-
E
Q
T
-
E
-
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
-
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
--
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------------
R
G
G
----
T
-----------
P
-
D
E
V
A
----------
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
-----
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
-
G
A
A
A
A
-
C
D
F
H
T
-
A
-
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
--
A
G
V
A
G
G
C
M
T
--
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
-
Q
R
A
V
S
G
------
93
PsiBlast_CBE
86.99
33%
-98
- C4 -
3ZHX
2
DXR_MYCTU
A:
[22-396]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
---
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
D
--------
I
P
-----
Y
H
G
--
S
D
A
A
T
R
-
L
V
-
E
Q
T
-
E
-
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
-
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
--
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------------
R
G
G
----
T
-----------
P
-
D
E
V
A
----------
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
-------
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
-
G
A
A
A
A
-
C
D
F
H
T
-
A
-
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
--
A
G
V
A
G
G
C
M
T
--
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
-
Q
R
A
V
S
G
M
-----
94
PsiBlast_CBE
86.93
33%
-100
- C4 -
4RCV
3
?
B:
[29-403]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
---
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
D
--------
I
P
-----
Y
H
G
--
S
D
A
A
T
R
-
L
V
-
E
Q
T
-
E
-
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
-
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
--
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------------
R
G
G
----
T
-----------
P
-
D
E
V
A
----------
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
--
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
-
G
A
A
A
A
-
C
D
F
H
T
-
A
-
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
--
A
G
V
A
G
G
C
M
T
--
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
-
Q
R
A
V
S
G
M
-----
69
PsiBlast_CBE
86.89
33%
-100
- C4 -
3RAS
5
DXR_MYCTU
B:
[23-397]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
---
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
D
--------
I
P
-----
Y
H
G
--
S
D
A
A
T
R
-
L
V
-
E
Q
T
-
E
-
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
-
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
--
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------------
R
G
G
----
T
-----------
P
-
D
E
V
A
----------
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
-
G
A
A
A
A
-
C
D
F
H
T
-
A
-
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
--
A
G
V
A
G
G
C
M
T
--
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
-
Q
R
A
V
S
G
M
-----
66
PsiBlast_CBE
86.82
33%
-98
- C4 -
4AIC
4
DXR_MYCTU
A:
[23-397]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
---
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
D
--------
I
P
-----
Y
H
G
--
S
D
A
A
T
R
-
L
V
-
E
Q
T
-
E
-
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
-
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
--
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------------
R
G
G
----
T
-----------
P
-
D
E
V
A
----------
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
-
G
A
A
A
A
-
C
D
F
H
T
-
A
-
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
--
A
G
V
A
G
G
C
M
T
--
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
-
Q
R
A
V
S
G
M
-----
90
PsiBlast_CBE
86.47
33%
-101
- C4 -
3ZHY
3
DXR_MYCTU
B:
[22-396]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
---
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
Q
R
V
G
D
--------
I
P
-----
Y
H
G
--
S
D
A
A
T
R
-
L
V
-
E
Q
T
-
E
-
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
-
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
--
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------------
R
G
G
----
T
-----------
P
-
D
E
V
A
----------
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
--------
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
-
G
A
A
A
A
-
C
D
F
H
T
-
A
-
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
--
A
G
V
A
G
G
C
M
T
--
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
-
Q
R
A
V
S
G
------
104
HHSearch
86.27
40%
-97
- C4 -
3A06
4
DXR_THEMA
A:
[3-370]
E
R
T
L
V
I
L
G
A
T
G
S
I
G
T
Q
T
L
D
V
L
K
---
K
V
K
-
G
I
R
L
I
G
I
S
F
H
-
S
N
L
E
L
A
F
K
I
V
K
E
F
N
V
K
N
V
A
I
T
G
D
V
E
F
E
D
S
---------
S
I
N
-----
V
W
K
--
G
S
H
S
I
E
E
M
L
-
E
A
L
-
K
-
P
D
I
T
M
V
A
V
S
G
F
S
G
L
R
A
V
L
A
S
L
E
H
S
K
-
R
V
C
L
A
N
K
E
S
L
V
C
G
G
F
L
V
K
K
K
L
K
-
E
K
G
T
E
L
I
P
V
D
S
E
H
S
A
I
F
Q
V
M
--------------
E
P
-------------------
E
-
V
E
----------
K
V
V
L
T
A
S
G
G
A
L
R
D
W
K
I
S
K
I
D
R
A
R
P
E
D
V
L
K
H
P
V
W
N
M
G
A
R
I
T
V
D
S
A
T
M
V
N
K
A
F
E
V
L
E
A
M
E
L
F
E
L
P
F
E
K
I
E
V
K
I
H
R
E
G
L
V
H
G
A
V
V
L
P
D
G
N
V
K
M
V
V
S
P
P
D
M
R
I
P
I
S
Y
A
L
F
Y
P
R
R
-
V
-
A
-
L
E
P
--
F
F
-
L
R
T
-
I
S
L
S
F
E
D
P
D
P
E
K
Y
P
A
F
F
L
L
K
E
--
I
K
D
-
S
Y
--
A
L
R
T
A
F
N
A
A
D
E
V
A
V
E
A
F
L
K
G
R
I
R
F
G
G
I
H
R
V
I
E
K
T
L
E
E
F
Q
G
Y
P
-
Q
P
R
T
L
D
D
V
E
R
I
H
F
E
A
I
K
K
A
-
E
R
V
T
E
W
L
S
----
19
PsiBlast_PDB
85.54
39%
-102
- C4 -
3A14
4
DXR_THEMA
A:
[4-360]
-
R
T
L
V
I
L
G
A
T
G
S
I
G
T
Q
T
L
D
V
L
----
K
K
V
K
G
I
R
L
I
G
I
S
F
H
-
S
N
L
E
L
A
F
K
I
V
K
E
F
N
V
K
N
V
A
I
T
G
D
V
E
F
E
D
---------
S
S
I
N
-----
V
W
K
--
G
S
H
S
I
E
-
E
M
L
E
A
L
-
K
-
P
D
I
T
M
V
A
V
S
G
F
S
G
L
R
A
V
L
A
S
L
E
H
-
S
K
R
V
C
L
A
N
K
E
S
L
V
C
G
G
F
L
V
K
K
K
L
K
-
E
K
G
T
E
L
I
P
V
D
S
E
H
S
A
I
F
Q
V
M
--------------
E
P
E
--------------------
V
E
----------
K
V
V
L
T
A
S
G
G
A
L
R
D
W
K
I
S
K
I
D
R
A
R
P
E
D
V
L
--------
A
R
I
T
V
D
S
A
T
M
V
N
K
A
F
E
V
L
E
A
M
E
L
F
E
L
P
F
E
K
I
E
V
K
I
H
R
E
G
L
V
H
G
A
V
V
L
P
D
G
N
V
K
M
V
V
S
P
P
D
M
R
I
P
I
S
Y
A
L
F
Y
P
R
R
-
V
-
A
L
E
-
P
-
F
F
L
-
R
-
T
-
I
S
L
S
F
E
D
P
D
P
E
K
Y
P
A
F
F
L
L
K
E
--
I
K
D
S
Y
A
L
R
T
---
A
F
N
A
A
D
E
V
A
V
E
A
F
L
K
G
R
I
R
F
G
G
I
H
R
V
I
E
K
T
L
E
E
F
Q
G
Y
P
-
Q
P
R
T
L
D
D
V
E
R
I
H
F
E
A
I
K
K
A
-
E
R
V
T
E
W
L
S
----
89
PsiBlast_CBE
85.25
33%
-99
- C4 -
3ZHZ
1
DXR_MYCTU
A:
[22-396]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
---
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
-------
D
--------
I
P
-----
Y
H
G
--
S
D
A
A
T
R
-
L
V
-
E
Q
T
-
E
-
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
-
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
--
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------------
R
G
G
----
T
-----------
P
-
D
E
V
A
----------
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
A
H
P
-------
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
-
G
A
A
A
A
-
C
D
F
H
T
-
A
-
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
--
A
G
V
A
G
G
C
M
T
--
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
-
Q
R
A
V
S
G
M
-----
78
PsiBlast_CBE
85.06
33%
-104
- C4 -
2Y1D
2
DXR_MYCTU
A:
[23-397]
--
R
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
---
D
N
P
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
----------
D
--------
I
P
-----
Y
H
G
--
S
D
A
A
T
R
-
L
V
-
E
Q
T
-
E
-
A
D
V
V
L
N
A
L
V
G
A
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
-
L
A
L
A
N
K
E
S
L
V
A
G
G
S
L
V
L
R
A
A
R
-
P
G
--
Q
I
V
P
V
D
S
E
H
S
A
L
A
Q
C
L
--------------
R
G
G
----
T
-----------
P
-
D
E
V
A
----------
K
L
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
A
G
----------
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
G
W
P
R
R
V
S
-
G
A
A
A
A
-
C
D
F
H
T
-
A
-
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
A
R
Q
--
A
G
V
A
G
G
C
M
T
--
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
-
Q
R
A
V
S
G
M
-----
18
PsiBlast_PDB
84.81
39%
-101
- C4 -
3A06
4
DXR_THEMA
A:
[4-360]
-
R
T
L
V
I
L
G
A
T
G
S
I
G
T
Q
T
L
D
V
L
----
K
K
V
K
G
I
R
L
I
G
I
S
F
H
-
S
N
L
E
L
A
F
K
I
V
K
E
F
N
V
K
N
V
A
I
T
G
D
V
E
F
E
D
---------
S
S
I
N
-----
V
W
K
--
G
S
H
S
I
E
-
E
M
L
E
A
L
-
K
-
P
D
I
T
M
V
A
V
S
G
F
S
G
L
R
A
V
L
A
S
L
E
H
-
S
K
R
V
C
L
A
N
K
E
S
L
V
C
G
G
F
L
V
K
K
K
L
K
-
E
K
G
T
E
L
I
P
V
D
S
E
H
S
A
I
F
Q
V
M
--------------
E
P
E
--------------------
V
E
----------
K
V
V
L
T
A
S
G
G
A
L
R
D
W
K
I
S
K
I
D
R
A
R
P
E
D
V
L
K
H
P
V
W
N
M
G
A
R
I
T
V
D
S
A
T
M
V
N
K
A
F
E
V
L
E
A
M
E
L
F
E
L
P
F
E
K
I
E
V
K
I
H
R
E
G
L
V
H
G
A
V
V
L
P
D
G
N
V
K
M
V
V
S
P
P
D
M
R
I
P
I
S
Y
A
L
F
Y
P
R
R
-
V
-
A
L
E
-
P
-
F
F
L
-
R
-
T
-
I
S
L
S
F
E
D
P
D
P
E
K
Y
P
A
F
F
L
L
K
E
--
I
K
D
S
Y
A
L
R
T
---
A
F
N
A
A
D
E
V
A
V
E
A
F
L
K
G
R
I
R
F
G
G
I
H
R
V
I
E
K
T
L
E
E
F
Q
G
Y
P
-
Q
P
R
T
L
D
D
V
E
R
I
H
F
E
A
I
K
K
A
-
E
R
V
T
E
W
L
S
----
40
PsiBlast_CBE
83.81
39%
-102
- C4 -
3A06
3
DXR_THEMA
B:
[4-360]
-
R
T
L
V
I
L
G
A
T
G
S
I
G
T
Q
T
L
D
V
L
----
K
K
V
K
G
I
R
L
I
G
I
S
F
H
-
S
N
L
E
L
A
F
K
I
V
K
E
F
N
V
K
N
V
A
I
T
G
D
V
E
F
E
D
---------
S
S
I
N
-----
V
W
K
--
G
S
H
S
I
E
-
E
M
L
E
A
L
-
K
-
P
D
I
T
M
V
A
V
S
G
F
S
G
L
R
A
V
L
A
S
L
E
H
-
S
K
R
V
C
L
A
N
K
E
S
L
V
C
G
G
F
L
V
K
K
K
L
K
-
E
K
G
T
E
L
I
P
V
D
S
E
H
S
A
I
F
Q
V
M
--------------
E
P
E
--------------------
V
E
----------
K
V
V
L
T
A
S
G
G
A
L
R
D
W
K
I
S
K
I
D
R
A
R
P
E
D
V
L
K
H
P
V
W
N
M
G
A
R
I
T
V
D
S
A
T
M
V
N
K
A
F
E
V
L
E
A
M
E
L
F
E
L
P
F
E
K
I
E
V
K
I
H
R
E
G
L
V
H
G
A
V
V
L
P
D
G
N
V
K
M
V
V
S
P
P
D
M
R
I
P
I
S
Y
A
L
F
Y
P
R
R
-
V
-
A
L
E
-
P
-
F
F
L
-
R
-
T
-
I
S
L
S
F
E
D
P
D
P
E
K
Y
P
A
F
F
L
L
K
E
--
I
K
D
S
Y
A
L
R
T
---
A
F
N
A
A
D
E
V
A
V
E
A
F
L
K
G
R
I
R
F
G
G
I
H
R
V
I
E
K
T
L
E
E
F
Q
G
Y
P
-
Q
P
R
T
L
D
D
V
E
R
I
H
F
E
A
I
K
K
A
-
E
R
V
T
E
W
L
S
S
T
--
39
PsiBlast_CBE
82.68
39%
-103
- C4 -
3A14
3
DXR_THEMA
B:
[4-360]
-
R
T
L
V
I
L
G
A
T
G
S
I
G
T
Q
T
L
D
V
L
----
K
K
V
K
G
I
R
L
I
G
I
S
F
H
-
S
N
L
E
L
A
F
K
I
V
K
E
F
N
V
K
N
V
A
I
T
G
D
V
E
F
E
D
---------
S
S
I
N
-----
V
W
K
--
G
S
H
S
I
E
-
E
M
L
E
A
L
-
K
-
P
D
I
T
M
V
A
V
S
G
F
S
G
L
R
A
V
L
A
S
L
E
H
-
S
K
R
V
C
L
A
N
K
E
S
L
V
C
G
G
F
L
V
K
K
K
L
K
-
E
K
G
T
E
L
I
P
V
D
S
E
H
S
A
I
F
Q
V
M
--------------
E
P
E
--------------------
V
E
----------
K
V
V
L
T
A
S
G
G
A
L
R
D
W
K
I
S
K
I
D
R
A
R
P
E
D
V
L
K
-----
M
G
A
R
I
T
V
D
S
A
T
M
V
N
K
A
F
E
V
L
E
A
M
E
L
F
E
L
P
F
E
K
I
E
V
K
I
H
R
E
G
L
V
H
G
A
V
V
L
P
D
G
N
V
K
M
V
V
S
P
P
D
M
R
I
P
I
S
Y
A
L
F
Y
P
R
R
-
V
-
A
L
E
-
P
-
F
F
L
-
R
-
T
-
I
S
L
S
F
E
D
P
D
P
E
K
Y
P
A
F
F
L
L
K
E
--
I
K
D
S
Y
A
L
R
T
---
A
F
N
A
A
D
E
V
A
V
E
A
F
L
K
G
R
I
R
F
G
G
I
H
R
V
I
E
K
T
L
E
E
F
Q
G
Y
P
-
Q
P
R
T
L
D
D
V
E
R
I
H
F
E
A
I
K
K
A
-
E
R
V
T
E
W
L
S
S
T
--