@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0193: (2015-11-29 )
MNIENIQQEFFPLFDKIKKEGDPIYNARVGFNIVKSLIERGTGWNKDEIYEVLQKELNKMERAQQELEKEAERVLSRYIIDDDVKGAVKGVSIYGNHASIKLEDNKKEFKISEFLNSDFCQKNGISGFSTLHRDEKSGMHGFVAEEGEGKDKRKVRHYVVTDGSYEMTLNWYDKEGKKCTIRININANSIKLIGGNITEEQLKDLSKANWDVKIGGLFLHEIEFRKTRENEINMSFETAIKIFGRSIQTTDMNREIGSQNAMTSTTNSHAPTKENPPLPPHRVSSLKKGVEQRKTKSLDHQSNGQKVEFNKYIQSNTLDLHELNSMNVPKLLELLKKEQNTTQINLGWNSIDNKNAEKLFRQRGLVIMANCREEENPGDQGYNLQSLFEVPTPSPLRTSSLKKNVSDEQGENISFKPISQSQDNRQKDERYDNLTFVMFRYTTSGRKKTVTEEDLQVKSAVFALPTQDVTLKKVEGTFKSEDAKKSDNMRDKQTSQDGVASILARRAEIEFLYSESERGDGLSDPEDDRSGNKDEYLTLLNPQSDDKNAKRGEKYENCDCNDNLEHIYENTDWLCDDKQDNRQRDKRYDNHTFAMFVYTLPGSKRPDDLHRNEQKLDNQQQPEIQQQGQSHSRPQSDSKGNLDVKGIQPSALSEDGDRPISTSTDKRNTKQLEYGKNSKDHNSETCMVPSKPAGKESKSIQFTNPSNQMVGKLEKVLKKLDRESEKTVQQVAEGSVSINKPLSSVSTDGNMDAEQNSHTQSEETNLSTPEKTNVNSSTSFKELEQRLSQKNYELKKISSKVRYISPQTKEYLMEAELLKDSSTDIRKAIERKNAHTSPTTDKNSELYKLLEKDKTQLKVRVIEKVVEGASAKHTDNYDRNRITLGNKNRKLLWTKHVKQQQEKGKGISI
Atome Classification :
(20 SA)
--.........10........20........30....-....40........50........60.....--...70......-..80........90.......-.100..-.....110.......120..-.....130.......140.......150.......160.......170.......180....-...190.......200-.......210.......---220.......230.......240....--------------...250.......260.......270.......280.......290.......300.......310.......320.......330......-----------.340.......350.....---..360.......370........380.......390-.......400-.......410....-...420.......430.......440.......450.......460.......470........480......--------.490.......500.......510.-......520.......530.....-..540......-.550......---.560.......570.......580.......590....-.-..600..----------------------.....610.......620.......630.......640.......650.....-..660--........670....-...---------680.......690.......700.......710.......720.----......730.......740.......750.......760.......770......-.780.......790.......800........810.......820.......830.......840.......850..---.....860.......870.......880--........890.......900.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--M
N
I
E
N
I
Q
Q
E
F
F
P
L
F
D
K
I
KKEGDP
I
Y
NAR
V
G
F
N
I
V
K
-
S
L
I
ERGTGW
N
K
D
E
I
Y
E
V
L
Q
K
E
L
N
K
M
E
R
A
Q
Q
E
--
L
E
K
E
A
E
R
V
L
S
R
-
Y
IIDDDVKGAVK
G
V
S
I
YGN
H
A
-
S
I
K
LED-NK
K
E
F
K
I
S
E
F
L
N
S
D
F
C
QKNG-ISG
F
S
T
LHRDEKSGMHGFVAEEGEGKDK
R
K
V
R
H
Y
V
VTDG
S
Y
E
M
T
L
N
W
YDKEG
K
K
C
T
I
R
I
N
IN-A
N
S
I
K
L
IGGNI
T
E
E
Q
L
-
K
D
L
S
KAN
W
D
V
K
I
G
G
L
F
L
---
H
E
I
E
F
RKTRENEIN
M
S
F
E
T
A
I
K
I
FGRS--------------IQTTDM
N
R
EIGSQNAMTSTTNSHAPTKENPPLP
P
H
R
V
S
S
L
K
K
G
V
E
Q
R
K
T
KSLDHQSNG
Q
K
V
E
F
N
K
Y
I
QSNTLD
L
H
ELNSM
N
V
P
K
L
L
E
L
L
K
KE-----------QNT
T
Q
I
N
LGWNSIDNK
N
A
E
---
K
L
F
R
QR
G
L
V
I
M
ANC-REEENPGDQGY
N
L
Q
S
L
FEVPT-PSPL
R
T
S
S
L
K-KNVSDEQGEN
I
S
F
K-PISQSQDN
R
Q
K
D
E
RYDN
L
T
F
V
M
F
R
Y
TTSGRKKTV
T
E
E
D
L
Q
V
K
S
A
V
F
ALPTQD
V
T
L
-
K
KVEGTFKSEDAKKSDN--------MRDKQTS
Q
D
G
V
A
S
I
L
A
RR
A
E
I
E
F
L
Y-SESERGDGLSDPEDDRSGNKD
E
Y
L
-
T
L
LNPQSDDKN-AKRGEKYENC---DCND
N
L
E
H
I
YENT
D
W
LCDDKQD
N
R
Q
R
D
KRYDN
H
T
F
A
M
F
-
V
-
Y
TLPGSK----------------------RP
D
D
L
H
R
N
E
Q
KLDNQQQ
P
E
I
Q
Q
QGQSHSRPQSDSKGNL
D
V
KGIQPSALSEDGD-RPIS---TSTDKRNT
K
Q
LEYGK-NSK---------DHNSETCMVPSKPAGKES
K
S
I
Q
FTNP
S
N
Q
M
V
G
K
L
E
K
V
L
K
K
LD
R
E
----
S
E
K
T
V
Q
Q
V
AEGS
V
S
INKPLSSVSTDGNMDAEQNSHTQSEETNLSTPEKTNVNSST-
S
F
K
E
L
E
Q
R
L
S
QKNY
E
L
K
K
I
S
S
K-
V
R
YISP
Q
T
K
E
Y
L
M
E
A
E
L
LKDS
S
T
D
I
R
K
A
I
E
RKNAHTSPTTDK
N
S
E
L
Y
K
L
L
E
KD
K
---
T
Q
L
K
V
R
V
I
E
K
V
V
EGASAKHTDNYDRN
R
---
I
T
LGNKN
R
K
L
L
W
T
K
H
V
K
Q
Q
Q
EKGKGISI
22
PsiBlast_CBE
70.34
33%
87
- C8 -
3PRX
1
?
D:
[1400-1468]
-----------------------------------------------------------------------
L
S
K
G
V
D
R
Y
I
S
R
-
Y
E
V
D
N
N
M
A
Q
K
V
-
A
V
I
I
Y
L
N
K
V
-
S
-
H
S
E
D
-
E
C
L
H
F
K
I
L
K
H
F
E
V
G
F
I
Q
P
G
S
-
V
K
V
Y
S
Y
Y
N
L
D
E
K
C
T
K
F
Y
H
P
D
K
G
T
G
L
L
N
K
I
C
I
G
N
V
C
R
C
A
G
E
T
C
S
S
L
N
H
Q
E
R
I
D
V
P
L
Q
I
E
K
A
C
E
-
T
N
V
D
Y
V
Y
K
T
K
L
L
R
I
E
E
-
Q
D
G
N
D
I
Y
V
M
D
V
L
E
V
I
K
Q
---
G
T
D
E
N
P
R
A
K
T
H
Q
Y
I
S
Q
R
K
C
Q
E
A
L
N
L
K
V
--------------
N
D
D
Y
L
I
W
G
S
R
S
D
L
L
P
T
K
D
K
I
S
Y
I
I
T
K
N
T
W
I
E
R
W
P
H
E
D
E
C
Q
E
E
E
F
Q
K
L
C
D
D
F
A
Q
F
S
Y
T
L
T
E
F
G
C
P
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
70.32
33%
87
- C8 -
3PRX
1
?
B:
[1400-1468]
-----------------------------------------------------------------------
L
S
K
G
V
D
R
Y
I
S
R
-
Y
E
V
D
N
N
M
A
Q
K
V
-
A
V
I
I
Y
L
N
K
V
-
S
-
H
S
E
D
-
E
C
L
H
F
K
I
L
K
H
F
E
V
G
F
I
Q
P
G
S
-
V
K
V
Y
S
Y
Y
N
L
D
E
K
C
T
K
F
Y
H
P
D
K
G
T
G
L
L
N
K
I
C
I
G
N
V
C
R
C
A
G
E
T
C
S
S
L
N
H
Q
E
R
I
D
V
P
L
Q
I
E
K
A
C
E
-
T
N
V
D
Y
V
Y
K
T
K
L
L
R
I
E
E
-
Q
D
G
N
D
I
Y
V
M
D
V
L
E
V
I
K
Q
---
G
T
D
E
N
P
R
A
K
T
H
Q
Y
I
S
Q
R
K
C
Q
E
A
L
N
L
K
V
--------------
N
D
D
Y
L
I
W
G
S
R
S
D
L
L
P
T
K
D
K
I
S
Y
I
I
T
K
N
T
W
I
E
R
W
P
H
E
D
E
C
Q
E
E
E
F
Q
K
L
C
D
D
F
A
Q
F
S
Y
T
L
T
E
F
G
C
P
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
69.81
33%
88
- C8 -
3PVM
1
?
B:
[1400-1468]
-----------------------------------------------------------------------
L
S
K
G
V
D
R
Y
I
S
R
-
Y
E
V
D
N
N
M
A
Q
K
V
-
A
V
I
I
Y
L
N
K
V
-
S
-
H
S
E
D
-
E
C
L
H
F
K
I
L
K
H
F
E
V
G
F
I
Q
P
G
S
-
V
K
V
Y
S
Y
Y
N
L
D
E
K
C
T
K
F
Y
H
P
D
K
G
T
G
L
L
N
K
I
C
I
G
N
V
C
R
C
A
G
E
T
C
S
S
L
N
H
Q
E
R
I
D
V
P
L
Q
I
E
K
A
C
E
-
T
N
V
D
Y
V
Y
K
T
K
L
L
R
I
E
E
-
Q
D
G
N
D
I
Y
V
M
D
V
L
E
V
I
K
Q
---
G
T
D
E
N
P
R
A
K
T
H
Q
Y
I
S
Q
R
K
C
Q
E
A
L
N
L
K
V
--------------
N
D
D
Y
L
I
W
G
S
R
S
D
L
L
P
T
K
D
K
I
S
Y
I
I
T
K
N
T
W
I
E
R
W
P
H
E
D
E
C
Q
E
E
E
F
Q
K
L
C
D
D
F
A
Q
F
S
Y
T
L
T
E
F
G
C
P
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
69.76
33%
88
* C8 *
3PVM
1
?
D:
[1400-1468]
-----------------------------------------------------------------------
L
S
K
G
V
D
R
Y
I
S
R
-
Y
E
V
D
N
N
M
A
Q
K
V
-
A
V
I
I
Y
L
N
K
V
-
S
-
H
S
E
D
-
E
C
L
H
F
K
I
L
K
H
F
E
V
G
F
I
Q
P
G
S
-
V
K
V
Y
S
Y
Y
N
L
D
E
K
C
T
K
F
Y
H
P
D
K
G
T
G
L
L
N
K
I
C
I
G
N
V
C
R
C
A
G
E
T
C
S
S
L
N
H
Q
E
R
I
D
V
P
L
Q
I
E
K
A
C
E
-
T
N
V
D
Y
V
Y
K
T
K
L
L
R
I
E
E
-
Q
D
G
N
D
I
Y
V
M
D
V
L
E
V
I
K
Q
---
G
T
D
E
N
P
R
A
K
T
H
Q
Y
I
S
Q
R
K
C
Q
E
A
L
N
L
K
V
--------------
N
D
D
Y
L
I
W
G
S
R
S
D
L
L
P
T
K
D
K
I
S
Y
I
I
T
K
N
T
W
I
E
R
W
P
H
E
D
E
C
Q
E
E
E
F
Q
K
L
C
D
D
F
A
Q
F
S
Y
T
L
T
E
F
G
C
P
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Fugue
61.22
13%
43
- C4 -
2HG4
2
ERYA3_SACER
A:
[9-901]
EE
K
L
R
R
Y
L
K
R
T
V
T
E
L
D
S
V
T
A
R
L
R
E
V
E
H
R
A
G
E
P
I
A
I
V
G
M
A
C
R
F
P
G
D
V
D
S
P
E
S
F
W
E
F
V
S
G
G
G
D
A
I
A
E
A
P
A
D
RG
W
E
P
D
P
D
A
R
L
G
G
M
L
A
A
A
G
D
F
D
A
G
F
F
G
I
S
P
R
E
A
L
A
M
D
P
Q
Q
R
I
M
L
E
I
S
W
E
A
L
E
R
A
G
H
D
P
V
S
L
R
G
S
A
T
G
V
F
T
G
V
G
T
V
D
Y
G
P
R
P
D
E
A
P
D
E
V
L
G
Y
V
G
T
G
T
A
S
S
V
A
S
G
R
V
A
Y
C
L
G
L
---
E
G
P
A
--------
M
T
V
D
T
A
C
S
S
G
L
T
A
L
H
L
A
M
E
S
L
R
R
D
E
C
G
L
A
L
A
G
G
V
T
V
MS
S
P
G
A
F
T
E
F
R
S
Q
G
-
G
L
A
A
D
G
R
C
K
P
F
S
K
A
AD
G
F
G
L
A
E
G
A
G
V
L
V
L
Q
R
L
S
A
A
R
R
E
G
R
P
V
L
A
V
L
R
G
S
A
V
N
Q
D
G
A
S
N
G
L
T
A
P
S
G
P
A
Q
Q
R
V
I
R
R
A
L
E
N
A
------
G
V
R
A
G
D
V
D
Y
V
E
A
H
G
T
G
T
R
L
G
D
P
I
E
V
H
A
L
L
S
T
Y
G
A
E
-----------
R
D
P
D
D
-
P
L
W
I
G
S
V
----
K
S
---
N
I
G
H
T
Q
A
A
A
G
V
A
G
V
M
K
-----------
A
V
L
A
L
R
H
G
E
M
P
R
T
L
H
F
---------
D
E
P
S
P
Q
I
E
W
A
V
S
V
V
S
Q
A
R
S
W
P
A
G
E
R
P
R
R
A
G
V
S
S
F
G
I
S
G
T
N
A
H
V
I
V
E
E
A
P
E
A
D
G
P
V
P
L
V
L
S
G
R
D
E
Q
A
M
R
A
Q
A
G
R
L
A
D
H
L
A
R
E
P
R
N
S
L
R
D
T
G
F
T
L
A
T
R
R
S
A
W
E
H
R
A
V
V
V
G
D
R
D
E
A
L
A
G
L
-
R
A
V
A
D
G
R
I
A
D
R
T
A
T
G
Q
A
R
T
R
R
G
V
A
M
V
F
P
G
Q
G
A
Q
W
Q
G
M
A
R
D
L
L
R
E
S
Q
V
F
A
D
S
I
R
D
C
E
R
A
L
A
P
H
V
D
W
S
L
T
D
L
L
S
G
A
R
P
L
D
R
V
D
V
V
Q
P
A
L
F
A
V
M
V
S
L
A
A
L
W
----------------------
R
S
H
G
V
E
P
A
--
A
V
V
G
H
S
Q
G
E
I
A
A
A
H
V
A
G
A
L
T
L
E
D
A
A
K
L
V
A
V
R
S
R
V
L
R
R
L
G
G
Q
G
G
M
A
S
F
G
---
L
G
T
E
Q
A
A
E
R
I
G
R
F
A
G
-
A
--------------------
L
S
I
A
S
V
N
G
P
R
S
V
V
V
A
G
E
S
----
G
P
L
D
E
L
I
A
E
C
E
A
E
----
A
H
K
-
A
R
R
I
P
V
D
Y
A
S
H
S
P
Q
V
E
S
L
R
E
E
L
L
T
E
L
A
G
I
S
P
V
S
A
D
V
A
L
Y
S
T
T
T
G
Q
P
I
D
T
A
T
M
D
T
A
Y
W
Y
A
N
L
R
E
Q
V
----
R
F
Q
D
A
-
T
R
Q
L
A
E
A
G
F
D
A
F
V
E
V
S
P
H
P
V
L
T
V
G
I
E
A
T
L
D
S
A
-----
L
P
A
D
A
G
A
C
V
V
G
T
L
R
R
D
R
GG
L
A
D
F
H
T
A
L
G
E
A
Y
A
Q
G
V
E
V
D
W
S
P
A
F
A
D
A
R
P
V
E
L
P
V
Y
P
F
Q
R
Q
R
Y
W
L
P
I
-------------
40
Fugue
56.92
13%
79
- C3 -
5CWW
-
?
B:
[3-593]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
K
S
F
A
-
P
A
W
L
N
E
P
A
P
G
H
K
L
F
A
----
P
K
-
P
G
P
R
R
T
I
A
R
R
G
T
E
I
F
V
A
C
G
K
Q
I
R
W
G
-
D
L
A
Q
L
K
E
S
W
E
S
R
P
S
D
D
G
A
A
T
A
G
Y
R
I
I
K
T
P
V
A
D
D
I
R
Q
L
V
M
S
P
N
Q
D
F
L
A
V
L
T
S
H
T
V
H
-
I
C
I
L
P
D
S
S
H
L
H
I
Q
D
T
T
P
--------
F
K
P
K
F
W
T
L
G
P
T
T
H
V
T
S
R
S
A
V
V
S
A
V
W
H
P
L
G
V
N
G
H
A
L
V
T
V
T
E
D
-------
A
I
-
V
R
V
W
E
L
S
T
A
D
R
-
W
T
F
D
A
P
T
L
A
I
---
D
L
K
K
L
A
D
A
T
Y
L
D
Q
D
F
G
V
S
T
S
A
T
N
K
G
F
S
P
D
A
F
D
M
E
V
A
A
A
-
C
-
F
P
T
R
D
S
G
GWAPM
T
L
W
L
A
M
TSG
D
V
Y
A
L
C
PL
L
P
Q
R
W
T
P
P
P
T
L
I
P
S
L
S
A
S
I
V
A
K
V
A
A
A
E
D
N
P
E
S
T
P
E
E
R
L
V
A
Q
Q
Q
L
E
W
M
S
E
I
D
N
Q
-
E
P
K
L
---
V
E
E
A
T
G
E
A
T
I
E
V
Y
T
R
-
P
S
R
PGLVPKLQG
P
F
D
F
D
L
N
P
E
D
E
Q
D
D
E
V
E
L
K
D
I
Y
V
I
G
E
K
P
R
N
G
L
S
L
N
I
I
C
L
L
S
T
S
G
----
Q
V
K
I
C
L
D
I
D
G
V
E
A
Q
W
L
P
P
R
S
K
N
K
R
L
F
A
P
P
P
E
P
P
S
L
L
T
F
Q
T
F
D
T
L
K
P
A
E
V
T
P
D
G
W
P
-
M
F
S
E
D
----
A
T
S
P
Y
S
F
Y
V
T
H
P
A
G
I
T
Y
I
S
L
T
P
W
V
F
R
L
E
S
E
L
Q
S
D
S
E
A
G
T
E
F
R
I
D
L
L
A
K
------
G
Q
G
S
E
R
D
R
I
F
T
Q
T
R
---
T
Q
S
P
L
---------
A
A
A
T
S
I
D
D
P
D
L
G
Y
---
F
I
L
S
A
T
Q
T
D
P
I
A
L
F
F
E
T
P
----------
14
PsiBlast_PDB
47.87
27%
118
- C5 -
2OYB
-
OSPA_BORBU
O:
[102-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
S
D
G
S
-
T
L
V
S
KYV
T
S
K
D
K
S
S
T
----
Y
E
K
F
N
E
K
---------
G
E
V
S
E
K
Y
I
T
R
A
-----
D
G
T
R
L
E
Y
T
G
I
K
S
D
G
S
G
K
A
K
E
V
L
K
G
Y
V
L
E
GTLT
A
E
K
T
T
L
V
V
K
E
G
T
V
T
L
S
K
---
N
I
S
K
S
G
E
V
S
V
E
L
N
----
D
T
D
S
S
A
A
T
K
K
T
A
A
W
N
S
G
T
-
S
T
L
T
I
T
V
N
-
S
K
K
T
K
D
L
V
F
T
S
S
N
-----
T
I
T
V
Q
Q
Y
D
S
N
G
T
S
L
E
G
S
A
V
E
I
T
K
L
D
E
I
K
N
A
L
K
-------------------------------------------------------------------------------
11
PsiBlast_PDB
47.47
24%
117
- C5 -
2I5V
1
OSPA_BORBU
O:
[80-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
S
D
G
S
-
T
L
V
S
---
K
K
V
T
S
K
D
K
I
I
I
I
I
K
F
-
N
E
K
---------
G
E
V
S
E
K
I
I
T
R
A
-----
D
G
T
R
L
E
Y
T
G
I
K
S
D
G
S
G
K
A
K
E
V
L
K
G
Y
V
L
E
GTLT
A
E
K
T
T
L
V
V
K
E
G
T
V
T
L
S
K
---
N
I
S
K
S
G
E
V
S
V
E
L
N
----
D
T
D
S
S
A
A
T
K
K
T
A
A
W
N
S
G
T
-
S
T
L
T
I
T
V
N
-
S
K
K
T
K
D
L
V
F
T
S
S
N
-----
T
I
T
V
Q
Q
Y
D
S
N
G
T
S
L
E
G
S
A
V
E
I
T
K
L
D
E
I
K
N
A
L
K
-------------------------------------------------------------------------------
8
PsiBlast_PDB
47.39
24%
122
- C5 -
2G8C
3
OSPA_BORBU
O:
[80-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
S
D
G
S
-
T
L
V
S
---
K
K
V
T
S
K
D
K
S
S
T
E
E
K
F
-
N
E
K
---------
G
E
V
S
E
K
I
I
T
R
A
-----
D
G
T
R
L
E
Y
T
G
I
K
S
D
G
S
G
K
A
K
E
V
L
K
G
Y
V
L
E
GTLT
A
E
K
T
T
L
V
V
K
E
G
T
V
T
L
S
K
---
N
I
S
K
S
G
A
V
S
V
E
L
N
----
D
T
D
S
S
A
A
T
K
K
T
A
A
W
N
S
G
T
-
S
T
L
T
I
T
V
N
-
S
K
K
T
K
D
L
V
F
T
S
S
N
-----
T
I
T
V
Q
Q
Y
D
S
N
G
T
S
L
E
G
S
A
V
E
I
T
K
L
D
E
I
K
N
A
L
K
-------------------------------------------------------------------------------
9
PsiBlast_PDB
47.28
25%
96
- C5 -
1OSP
-
OSPA_BORBU
O:
[102-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
E
D
G
K
-
T
L
V
S
---
K
K
V
T
S
K
D
K
S
S
T
E
E
K
F
-
N
E
K
---------
G
E
V
S
E
K
I
I
T
R
A
-----
D
G
T
R
L
E
Y
T
G
I
K
S
D
G
S
G
K
A
K
E
V
L
K
G
Y
V
L
E
GTLT
A
E
K
T
T
L
V
V
K
E
G
T
V
T
L
S
K
---
N
I
S
K
S
G
E
V
S
V
E
L
N
----
D
T
D
S
S
A
A
T
K
K
T
A
A
W
N
S
G
T
-
S
T
L
T
I
T
V
N
-
S
K
K
T
K
D
L
--
V
F
T
K
-
E
N
T
I
T
V
Q
--
Q
Y
D
S
N
G
T
K
L
E
G
S
A
V
E
I
T
K
L
D
E
I
K
N
A
L
K
-------------------------------------------------------------------------------
6
PsiBlast_PDB
46.99
24%
114
- C5 -
2I5Z
1
OSPA_BORBU
O:
[80-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
S
D
G
S
-
T
L
V
S
---
K
K
V
T
S
K
D
K
S
S
T
E
E
K
A
-
N
E
K
---------
G
E
V
S
E
K
I
I
T
R
A
-----
D
G
T
R
L
E
Y
T
G
I
K
S
D
G
S
G
K
A
K
E
V
L
K
G
Y
V
L
E
GTLT
A
E
K
T
T
L
V
V
K
E
G
T
V
T
L
S
K
---
N
I
S
K
S
G
E
V
S
V
E
L
N
----
D
T
D
S
S
A
A
T
K
K
T
A
A
W
N
S
G
T
-
S
T
L
T
I
T
V
N
-
S
K
K
T
K
D
L
V
F
T
S
S
N
-----
T
I
T
V
Q
Q
Y
D
S
N
G
T
S
L
E
G
S
A
V
E
I
T
K
L
D
E
I
K
N
A
L
K
-------------------------------------------------------------------------------
10
PsiBlast_PDB
46.06
25%
101
- C5 -
1FJ1
-
OSPA_BORBU
E:
[102-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
E
D
G
K
-
T
L
V
S
---
K
K
V
T
S
K
D
K
S
S
T
E
E
K
F
-
N
E
K
---------
G
E
V
S
E
K
I
I
T
R
A
-----
D
G
T
R
L
E
Y
T
G
I
K
S
D
G
S
G
K
A
K
E
V
L
K
G
Y
V
L
E
GTLT
A
E
K
T
T
L
V
V
K
E
G
T
V
T
L
S
K
---
N
I
S
K
S
G
E
V
S
V
E
L
N
----
D
T
D
S
S
A
A
T
K
K
T
A
A
W
N
S
G
T
-
S
T
L
T
I
T
V
N
-
S
K
K
T
K
D
L
--
V
F
T
K
-
E
N
T
I
T
V
Q
--
Q
Y
D
S
N
G
T
K
L
E
G
S
A
V
E
I
T
K
L
D
E
I
K
N
A
L
K
-------------------------------------------------------------------------------
7
PsiBlast_PDB
44.26
25%
136
- C5 -
3CKF
-
?
A:
[107-248]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
L
V
S
K
K
V
T
R
A
D
G
T
R
L
E
Y
T
G
I
K
S
D
G
S
G
K
A
K
E
V
L
K
G
Y
V
L
E
G
T
L
T
A
E
K
T
T
L
V
V
K
E
G
T
V
T
L
S
K
---
N
I
S
K
S
G
E
V
S
V
E
L
N
----
D
T
D
S
S
A
A
T
K
K
T
A
A
W
N
S
G
T
-
S
T
L
T
I
T
V
N
-
S
K
K
T
K
D
L
V
F
T
S
S
N
-----
T
I
T
V
Q
Q
Y
D
S
N
G
T
S
L
E
G
S
A
V
E
I
T
K
L
D
E
I
K
N
A
L
K
-------------------------------------------------------------------------------
12
PsiBlast_PDB
43.75
27%
128
- C5 -
3AUM
-
OSPA_BORBU
O:
[145-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Y
T
G
I
K
S
D
G
S
G
K
A
K
E
V
L
K
G
Y
V
L
E
GTLT
A
E
K
T
T
L
V
V
K
E
G
T
V
T
L
S
K
---
N
I
S
K
S
G
E
V
S
V
E
L
N
----
D
T
D
S
S
A
A
T
K
K
T
A
A
W
N
S
G
T
-
S
T
L
T
I
T
V
N
-
S
K
K
T
K
D
L
V
F
T
S
S
N
-
T
I
T
V
----
Q
Q
Y
D
S
N
G
T
S
L
E
G
S
A
V
E
I
T
K
L
D
E
I
K
N
A
L
K
-------------------------------------------------------------------------------
13
PsiBlast_PDB
43.19
27%
138
- C5 -
2OY5
-
OSPA_BORBU
O:
[145-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Y
T
G
I
K
S
D
G
S
G
K
A
K
E
V
L
K
G
Y
V
L
E
GTLT
A
E
K
T
T
L
V
V
K
E
G
T
V
T
L
S
K
---
N
I
S
K
S
G
E
V
S
V
E
L
N
----
D
T
D
S
S
A
A
T
K
K
T
A
A
W
N
S
G
T
-
S
T
L
T
I
T
V
N
-
S
K
K
T
K
D
L
V
F
T
S
S
N
-----
T
I
T
V
Q
Q
Y
D
S
N
G
T
S
L
E
G
S
A
V
E
I
T
K
L
D
E
I
K
N
A
L
K
-------------------------------------------------------------------------------
28
HHSearch
38.80
20%
109
- C6 -
2CP9
-
EFTS_HUMAN
A:
[7-51]
-----------------------------
G
S
S
K
E
L
L
M
-
K
L
R
R
K
-
T
G
Y
S
F
V
N
C
K
K
A
L
E
T
C
G
G
D
L
K
Q
A
E
I
W
--
L
H
K
E
A
Q
K
E
G
W
S
-
K
A
A
S
G
P
S
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
38.40
33%
74
- C8 -
3HS0
1
?
C:
[137-205]
-----------------------------------------------------------------------
L
S
K
G
V
D
R
Y
I
S
R
-
Y
E
V
D
N
N
M
A
Q
K
V
-
A
V
I
I
Y
L
N
K
V
-
S
-
H
S
E
D
-
E
C
L
H
F
K
I
L
K
H
F
E
V
G
F
I
Q
P
G
S
-
V
K
V
Y
S
Y
Y
N
L
D
E
K
C
T
K
F
Y
H
P
D
K
G
T
G
L
L
N
K
I
C
I
G
N
V
C
R
C
A
G
E
T
C
S
S
L
N
H
Q
E
R
I
D
V
P
L
Q
I
E
K
A
C
E
-
T
N
V
D
Y
V
Y
K
T
K
L
L
R
I
E
E
-
Q
D
G
N
D
I
Y
V
M
D
V
L
E
V
I
K
Q
---
G
T
D
E
N
P
R
A
K
T
H
Q
Y
I
S
Q
R
K
C
Q
E
A
L
N
L
K
V
--------------
N
D
D
Y
L
I
W
G
S
R
S
D
L
L
P
T
K
D
K
I
S
Y
I
I
T
K
N
T
W
I
E
R
W
P
H
E
D
E
C
Q
E
E
E
F
Q
K
L
C
D
D
F
A
Q
F
S
Y
T
L
T
E
F
G
C
P
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
38.36
33%
79
- C8 -
3HRZ
2
?
C:
[137-205]
-----------------------------------------------------------------------
L
S
K
G
V
D
R
Y
I
S
R
-
Y
E
V
D
N
N
M
A
Q
K
V
-
A
V
I
I
Y
L
N
K
V
-
S
-
H
S
E
D
-
E
C
L
H
F
K
I
L
K
H
F
E
V
G
F
I
Q
P
G
S
-
V
K
V
Y
S
Y
Y
N
L
D
E
K
C
T
K
F
Y
H
P
D
K
G
T
G
L
L
N
K
I
C
I
G
N
V
C
R
C
A
G
E
T
C
S
S
L
N
H
Q
E
R
I
D
V
P
L
Q
I
E
K
A
C
E
-
T
N
V
D
Y
V
Y
K
T
K
L
L
R
I
E
E
-
Q
D
G
N
D
I
Y
V
M
D
V
L
E
V
I
K
Q
---
G
T
D
E
N
P
R
A
K
T
H
Q
Y
I
S
Q
R
K
C
Q
E
A
L
N
L
K
V
--------------
N
D
D
Y
L
I
W
G
S
R
S
D
L
L
P
T
K
D
K
I
S
Y
I
I
T
K
N
T
W
I
E
R
W
P
H
E
D
E
C
Q
E
E
E
F
Q
K
L
C
D
D
F
A
Q
F
S
Y
T
L
T
E
F
G
C
P
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
38.02
33%
83
- C8 -
3FRP
-
?
B:
[137-205]
-----------------------------------------------------------------------
L
S
K
G
V
D
R
Y
I
S
R
-
Y
E
V
D
N
N
M
A
Q
K
V
-
A
V
I
I
Y
L
N
K
V
-
S
-
H
S
E
D
-
E
C
L
H
F
K
I
L
K
H
F
E
V
G
F
I
Q
P
G
S
-
V
K
V
Y
S
Y
Y
N
L
D
E
K
C
T
K
F
Y
H
P
D
K
G
T
G
L
L
N
K
I
C
I
G
N
V
C
R
C
A
G
E
T
C
S
S
L
N
H
Q
E
R
I
D
V
P
L
Q
I
E
K
A
C
E
-
T
N
V
D
Y
V
Y
K
T
K
L
L
R
I
E
E
-
Q
D
G
N
D
I
Y
V
M
D
V
L
E
V
I
K
Q
---
G
T
D
E
N
P
R
A
K
T
H
Q
Y
I
S
Q
R
K
C
Q
E
A
L
N
L
K
V
--------------
N
D
D
Y
L
I
W
G
S
R
S
D
L
L
P
T
K
D
K
I
S
Y
I
I
T
K
N
T
W
I
E
R
W
P
H
E
D
E
C
Q
E
E
E
F
Q
K
L
C
D
D
F
A
Q
F
S
Y
T
L
T
E
F
G
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
35.33
26%
66
- C9 -
4R07
1
TLR8_HUMAN
A:
[62-159]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
L
Q
N
L
T
K
I
N
L
N
H
N
P
N
V
-----------
N
G
L
N
I
T
D
G
A
F
L
N
L
K
N
L
R
E
L
L
L
E
D
NQLPQIPSGLP
E
S
L
T
E
L
S
L
I
Q
N
N
I
Y
N
I
T
K
E
GIS
R
L
I
N
L
K
N
L
Y
L
A
W
N
C
-
Y
F
N
K
V
C
E
K
T
N
I
E
D
G
V
F
E
T
L
T
N
-
L
E
L
L
S
L
S
F
N
S
-
L
S
H
V
P
P
K
L
P
S
S
L
R
K
-
L
F
L
S
N
T
Q
I
K
Y
I
S
E
E
D
F
K
G
L
I
N
L
T
L
L
D
L
S
G
N
C
P
R
C
F
N
A
P
F
P
C
V
P
C
D
G
G
A
S
I
N
I
D
R
F
-
A
F
Q
N
L
T
Q
L
R
Y
L
N
L
S
S
T
S
--------
L
R
K
I
N
A
A
W
F
K
N
M
P
H
L
K
V
L
D
L
E
F
N
Y
L
-
V
G
E
I
A
S
G
A
F
L
T
M
L
P
R
L
E
I
L
D
L
S
F
N
-
Y
I
K
G
S
Y
P
Q
H
I
N
-
I
S
R
N
F
S
K
L
L
S
---
L
R
A
L
H
L
R
G
Y
V
F
Q
E
L
R
E
D
D
F
Q
P
L
M
Q
L
P
N
L
S
T
I
N
L
G
I
N
F
I
-
K
-
Q
I
D
F
K
L
F
----------------------
Q
N
F
S
N
L
E
I
I
Y
L
S
E
N
R
I
S
P
T
D
F
E
F
D
P
H
S
N
F
Y
H
F
T
R
P
L
I
K
P
Q
C
A
A
Y
G
K
A
L
D
L
S
L
N
-
S
I
F
F
---
I
G
P
N
Q
F
E
N
L
P
D
I
A
C
L
-
N
L
S
---------
A
N
S
N
A
Q
V
L
S
G
T
E
F
S
A
I
P
H
V
K
Y
L
D
L
T
N
N
R
L
D
F
D
N
A
S
A
L
T
E
L
S
D
L
E
----
V
L
D
L
S
Y
N
S
H
Y
F
R
I
A
G
V
T
H
H
L
E
F
I
Q
N
F
T
N
L
K
V
L
N
L
S
H
N
N
I
Y
T
L
T
D
K
Y
N
L
E
S
K
S
L
V
E
-
L
V
F
S
G
N
R
L
D
I
L
W
N
D
D
D
N
R
Y
I
S
I
-
F
K
G
L
K
N
L
T
R
L
D
L
S
L
N
R
L
K
H
I
P
N
E
A
F
L
N
L
P
A
S
L
T
E
L
H
I
N
D
N
M
L
K
F
F
N
W
T
L
L
Q
Q
F
P
---
R
L
E
L
L
D
L
R
G
N
K
L
L
F
L
T
D
S
L
S
D
F
T
S
S
L
R
---
T
L
L
L
S
H
N
R
I
S
H
L
P
S
G
F
L
S
E
V
S
S
L
K
H
L
D
L