@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0223: (2015-11-29 )
MCGIFGAVSDGDSVIPTLLAGLRKLEYRGYDSSGIAIINNEGKIEVQKSEGKVERLCEVVGNSRMSSSTVGIAHTRWATHGIPDLKNAHPIRTNNVVVAHNGVIENYNLLKKGLEERGIPFHTDTDTEVIPNMLTLYLNEGLSPIDSLFKCLSNLHGSFALVLLFAEYPDVLFVAKRSLPLAIGYNYNTVFAASDSNTLNTLVERISYLEDNDVAVIKSSGVSIYNNGAQVKRSIENNSSSSFLISKNGYSSFMLKEIFEQPCVLNKTINQFYKKYTEVISTSKKLFSKLSYITIVGCGSSYFAGLIAKYWLESVAQVRVYLEISSEFRYSNIRLEEGSIGLFISQSGETADTMEALRYAKSQKQTTISITNTFNSGIEKISDVVLHTLAGPEIGVASTKTFSTQLAILACFTLELAKIKDTIDEKRTKQLSNAINSIPEYVEYVLNVIKIQHIPDIILEHNSIILIGRGSSYGVAMEGALKIKELSYINTIGIAAGEMKHGSIALIDSSVLVIAIIPYDNLFFKTLSNIQEVIARKGKVIAFSDKQGVPFLREICKEVIQLPDIDNFISPIIYSVAMQFLAHSVAIEKGLDADCPRNLAKSVTVE
Atome Classification :
(27 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.....-..230..-.....240.......250.......260-......----.270-...--.-----...280...---.....290-----........300.......310.......320.......330.......340.......350.......360...-.-...370.......380.......390.......400.......410.......420....-...430.......440......-.-450........460.......470.......480.......490.......500.......510......-.520.......530.......540.......550.......560.-........570.......580.......590.......600....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MCGIFGAVSDG
D
S
V
I
P
T
L
L
A
G
L
R
K
L
EYRGYDSS
G
I
A
I
INNE
G
K
I
E
V
QKSE
G
K
V
E
R
L
C
E
V
VGNSRMSSSTVG
I
A
H
TRWATHGIPDLKNAHPIRTN
N
V
V
V
AHNGVI
E
N
Y
N
L
L
K
K
G
L
E
ERGIPFHTDTD
T
E
V
I
P
N
M
L
T
L
Y
L
NEGL
S
P
I
D
S
L
F
K
C
L
S
NLHG
S
F
A
L
V
L
L
FAEYP
D
V
L
F
V
AKRSL
P
L
A
I
GYNY
N
T
V
F
AASDS
N
T
L
N
T
L
V
E
R
I
S
YLEDN
D
V
A
V
I
KSSG
V
S
I
YNN-
G
A
Q
V
K
R
S
-IENNSS
S
S
F
L
I
SKNG
Y
S
S
F
M
L
K
E
I
F
EQP-C
V
L
N
K
T
----
I
N
Q
F
-
Y
K
K
--
Y
-----
T
E
V
I
S
-
T
S
K
---
K
L
F
SKL
S
------
Y
I
T
I
V
GC
G
S
S
Y
F
A
G
L
I
A
K
Y
W
L
E
S
V
A
Q
V
R
V
Y
L
E
ISSEFRYS
N
I
R
L
EEG
S
I
G
L
F
I
SQSGE
T
A
D
T
M
E
A
L
R
Y
A
KSQK
Q
-
T
-
T
I
S
I
T
N
T
F
N
S
G
I
E
K
I
S
D
V
V
L
H
TLAGPEIGVASTKTF
S
T
Q
L
A
I
L
A
C
F
T
L
E
L
A
K
I
K
D
T
I
D
E
K
-
R
T
K
Q
L
S
N
A
I
N
S
I
P
E
Y
V
E
Y
V
L
N
V
-
I
-
K
-IQHI
P
D
I
I
LEHN
S
I
I
L
I
GRGSSY
G
V
A
ME
G
A
L
K
I
K
E
L
S
Y
I
N
T
IGIAAGEMKH
G
S
I
A
L
IDS
S
V
L
V
I
A
I
IP-YD
N
L
F
F
K
T
L
S
N
I
Q
E
V
I
ARKG
K
V
I
A
FSDKQG
V
P
F
L
R
E
I
C
K
E
V
I--Q-LP
D
I
D
N
F
I
S
P
I
I
Y
S
V
A
M
Q
F
L
A
H
S
V
A
I
EKGLDADC
P
R
N
L
A
K
SVTVE
25
PsiBlast_CBE
97.02
39%
-103
- C2 -
2J6H
3
GLMS_ECOLI
B:
[1-608]
-
C
G
I
V
G
A
I
A
Q
R
D
-
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
-
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
-
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
N
T
LTGR
I
S
H
G
-
Q
V
D
--
L
-----
S
E
L
G
P
-
N
A
D
---
E
L
L
S
K
V
E
------
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
-
L
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
-
L
D
A
S
-
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
-
D
-
K
R
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
-
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
-
Q
D
A
G
F
V
S
S
D
N
M
H
I
I
--
E
-
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
1
PsiBlast_PDB
96.68
40%
-107
- C2 -
4AMV
1
GLMS_ECOLI
A:
[2-609]
-
C
G
I
V
G
A
I
A
Q
R
D
-
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
-
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
-
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
N
T
L
TGR
I
S
H
G
-
Q
V
D
--
L
-----
S
E
L
G
P
-
N
A
D
---
E
L
L
S
K
V
E
------
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
-
L
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
-
L
D
A
S
-
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
-
D
-
K
R
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
-
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
-
Q
D
A
G
F
V
S
S
D
N
M
H
I
I
--
E
-
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
21
PsiBlast_CBE
96.56
40%
-108
- C2 -
4AMV
2
GLMS_ECOLI
C:
[2-609]
-
C
G
I
V
G
A
I
A
Q
R
D
-
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
-
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
-
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
N
T
LTGR
I
S
H
G
-
Q
V
D
--
L
-----
S
E
L
G
P
-
N
A
D
---
E
L
L
S
K
V
E
------
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
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L
A
G
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P
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D
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F
R
Y
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L
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L
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Q
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G
E
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A
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T
L
A
G
L
R
L
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K
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L
G
Y
-
L
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
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I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
-
L
D
A
S
-
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
-
D
-
K
R
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
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G
A
L
K
L
K
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Y
I
H
A
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A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
-
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
-
Q
D
A
G
F
V
S
S
D
N
M
H
I
I
--
E
-
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
3
PsiBlast_PDB
96.20
39%
-104
- C2 -
2J6H
3
GLMS_ECOLI
A:
[1-608]
-
C
G
I
V
G
A
I
A
Q
R
D
-
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
-
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
-
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
N
T
L
TGR
I
S
H
G
-
Q
V
D
--
L
-----
S
E
L
G
P
-
N
A
D
---
E
L
L
S
K
V
E
------
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
-
L
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
-
L
D
A
S
-
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
-
D
-
K
R
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
-
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
-
Q
D
A
G
F
V
S
S
D
N
M
H
I
I
--
E
-
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
28
PsiBlast_CBE
96.09
39%
-114
- C2 -
3OOJ
1
GLMS_ECOLI
F:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
-
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
-
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
---------------
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
N
T
LTGR
I
S
H
G
-
Q
V
D
--
L
-----
S
E
L
G
P
-
N
A
D
---
E
L
L
S
K
V
E
------
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
G
-
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
-
L
D
A
S
-
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
-
D
-
K
R
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
-
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
-
Q
D
A
G
F
V
S
S
D
N
M
H
I
I
--
E
-
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
30
PsiBlast_CBE
96.01
39%
-111
- C2 -
3OOJ
7
GLMS_ECOLI
D:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
-
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
-
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
-------
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
N
T
LTGR
I
S
H
G
-
Q
V
D
--
L
-----
S
E
L
G
P
-
N
A
D
---
E
L
L
S
K
V
E
------
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
G
-
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
-
L
D
A
S
-
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
-
D
-
K
R
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
-
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
-
Q
D
A
G
F
V
S
S
D
N
M
H
I
I
--
E
-
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
22
PsiBlast_CBE
95.95
40%
-104
- C2 -
4AMV
2
GLMS_ECOLI
B:
[2-609]
-
C
G
I
V
G
A
I
A
Q
R
D
-
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
-
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
-
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
N
T
LTGR
I
S
H
G
-
Q
V
D
--
L
-----
S
E
L
G
P
-
N
A
D
---
E
L
L
S
K
V
E
------
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
-
L
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
-
L
D
A
S
-
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
-
D
-
K
R
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
-
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
-
Q
D
A
G
F
V
S
S
D
N
M
H
I
I
--
E
-
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
29
PsiBlast_CBE
95.87
39%
-107
- C2 -
3OOJ
2
GLMS_ECOLI
E:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
-
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
-
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
-------
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
N
T
L
T
G
R
I
S
H
G
-
Q
V
D
--
L
-----
S
E
L
G
P
-
N
A
D
---
E
L
L
S
K
V
E
------
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
G
-
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
-
L
D
A
S
-
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
-
D
-
K
R
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
-
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
-
Q
D
A
G
F
V
S
S
D
N
M
H
I
I
--
E
-
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
27
PsiBlast_CBE
95.71
39%
-111
- C2 -
3OOJ
14
GLMS_ECOLI
G:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
-
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
-
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
----
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
N
T
LTGR
I
S
H
G
-
Q
V
D
--
L
-----
S
E
L
G
P
-
N
A
D
---
E
L
L
S
K
V
E
------
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
G
-
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
-
L
D
A
S
-
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
-
D
-
K
R
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
-
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
-
Q
D
A
G
F
V
S
S
D
N
M
H
I
I
--
E
-
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
2
PsiBlast_PDB
95.58
40%
-104
- C2 -
1JXA
1
GLMS_ECOLI
A:
[1-608]
-
C
G
I
V
G
A
I
A
Q
R
D
-
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
-
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
-
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
N
T
L
TGR
I
S
H
G
-
Q
V
D
--
L
-----
S
E
L
G
P
-
N
A
D
---
E
L
L
S
K
V
E
------
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
-
L
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
-
L
D
A
S
-
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
-
D
-
K
R
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
-
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
-
Q
D
A
G
F
V
S
S
D
N
M
H
I
I
--
E
-
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
32
PsiBlast_CBE
95.46
39%
-107
- C2 -
3OOJ
7
GLMS_ECOLI
B:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
-
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
-
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
-
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
N
T
LTGR
I
S
H
G
-
Q
V
D
--
L
-----
S
E
L
G
P
-
N
A
D
---
E
L
L
S
K
V
E
------
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
G
-
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
-
L
D
A
S
-
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
-
D
-
K
R
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
-
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
-
Q
D
A
G
F
V
S
S
D
N
M
H
I
I
--
E
-
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
31
PsiBlast_CBE
95.10
39%
-106
- C2 -
3OOJ
7
GLMS_ECOLI
C:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
-
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
-
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
--------
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
N
T
L
T
GR
I
S
H
G
-
Q
V
D
--
L
-----
S
E
L
G
P
-
N
A
D
---
E
L
L
S
K
V
E
------
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
G
-
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
-
L
D
A
S
-
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
-
D
-
K
R
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
-
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
-
Q
D
A
G
F
V
S
S
D
N
M
H
I
I
--
E
-
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
6
PsiBlast_PDB
94.98
39%
-104
- C2 -
3OOJ
7
GLMS_ECOLI
A:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
-
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
-
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
-
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
N
T
L
TGR
I
S
H
G
-
Q
V
D
--
L
-----
S
E
L
G
P
-
N
A
D
---
E
L
L
S
K
V
E
------
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
G
-
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
-
L
D
A
S
-
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
-
D
-
K
R
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
-
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
-
Q
D
A
G
F
V
S
S
D
N
M
H
I
I
--
E
-
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
26
PsiBlast_CBE
94.93
39%
-103
- C2 -
3OOJ
14
GLMS_ECOLI
H:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
-
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
-
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
-
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
N
T
LTGR
I
S
H
G
-
Q
V
D
--
L
-----
S
E
L
G
P
-
N
A
D
---
E
L
L
S
K
V
E
------
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
G
-
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
-
L
D
A
S
-
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
-
D
-
K
R
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
-
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
-
Q
D
A
G
F
V
S
S
D
N
M
H
I
I
--
E
-
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
23
PsiBlast_CBE
94.39
40%
-102
- C2 -
1JXA
1
GLMS_ECOLI
C:
[1-608]
-
C
G
I
V
G
A
I
A
Q
R
D
-
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
-
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
-
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
N
T
LTGR
I
S
H
G
-
Q
V
D
--
L
-----
S
E
L
G
P
-
N
A
D
---
E
L
L
S
K
V
E
------
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
-
L
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
-
L
D
A
S
-
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
-
D
-
K
R
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
-
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
-
Q
D
A
G
F
V
S
S
D
N
M
H
I
I
--
E
-
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
24
PsiBlast_CBE
94.36
40%
-102
- C2 -
1JXA
1
GLMS_ECOLI
B:
[1-608]
-
C
G
I
V
G
A
I
A
Q
R
D
-
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
-
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
-
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
N
T
LTGR
I
S
H
G
-
Q
V
D
--
L
-----
S
E
L
G
P
-
N
A
D
---
E
L
L
S
K
V
E
------
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
-
L
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
-
L
D
A
S
-
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
-
D
-
K
R
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
-
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
-
Q
D
A
G
F
V
S
S
D
N
M
H
I
I
--
E
-
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
11
PsiBlast_PDB
73.13
37%
-103
- C2 -
2ZJ3
1
GFPT1_HUMAN
A:
[11-375]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
G
N
F
S
S
F
M
Q
K
E
I
F
E
Q
P
E
S
V
V
N
T
M
----
R
G
R
V
N
F
D
D
--
Y
-----
T
V
N
L
G
-
G
L
K
DH
I
K
E
I
Q
R
C
R
------
R
L
I
L
I
A
C
G
T
S
Y
H
A
G
V
A
T
R
Q
V
L
E
E
L
T
E
L
P
V
M
V
E
L
A
S
D
F
L
D
R
N
T
P
V
F
R
D
D
V
C
F
F
L
S
Q
S
G
E
T
A
D
T
L
M
G
L
R
Y
C
K
E
R
G
A
-
L
-
T
V
G
I
T
N
T
V
G
S
S
I
S
R
E
T
D
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
F
V
S
L
V
M
F
A
L
M
M
C
D
D
R
I
S
M
Q
E
R
-
R
-
K
E
I
M
L
G
L
K
R
L
P
D
L
I
K
E
V
L
S
M
D
D
-
E
-
I
Q
K
L
A
T
E
L
Y
H
Q
K
S
V
L
I
M
G
R
G
Y
H
Y
A
T
C
L
E
G
A
L
K
I
K
E
I
T
Y
M
H
S
E
G
I
L
A
G
E
L
K
H
G
P
L
A
L
V
D
K
L
M
P
V
I
M
I
I
M
-
R
D
H
T
Y
A
K
C
Q
N
A
L
Q
Q
V
V
A
R
Q
G
R
P
V
V
I
C
D
K
E
D
T
E
T
I
K
N
T
-
K
R
T
I
--
K
-
V
P
H
S
V
D
C
L
Q
G
I
L
S
V
I
P
L
Q
L
L
A
F
H
L
A
V
L
R
G
Y
D
V
D
F
P
R
N
L
A
K
S
V
T
V
E
12
PsiBlast_PDB
72.97
37%
-101
- C2 -
2ZJ4
1
GFPT1_HUMAN
A:
[11-375]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
G
N
F
S
S
F
M
Q
K
E
I
F
E
Q
P
E
S
V
V
N
T
M
----
R
G
R
V
N
F
D
D
--
Y
-----
T
V
N
L
G
-
G
L
K
DH
I
K
E
I
Q
R
C
R
------
R
L
I
L
I
A
C
G
T
S
Y
H
A
G
V
A
T
R
Q
V
L
E
E
L
T
E
L
P
V
M
V
E
L
A
S
D
F
L
D
R
N
T
P
V
F
R
D
D
V
C
F
F
L
S
Q
S
G
E
T
A
D
T
L
M
G
L
R
Y
C
K
E
R
G
A
-
L
-
T
V
G
I
T
N
T
V
G
S
S
I
S
R
E
T
D
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
F
V
S
L
V
M
F
A
L
M
M
C
D
D
R
I
S
M
Q
E
R
-
R
-
K
E
I
M
L
G
L
K
R
L
P
D
L
I
K
E
V
L
S
M
D
D
-
E
-
I
Q
K
L
A
T
E
L
Y
H
Q
K
S
V
L
I
M
G
R
G
Y
H
Y
A
T
C
L
E
G
A
L
K
I
K
E
I
T
Y
M
H
S
E
G
I
L
A
G
E
L
K
H
G
P
L
A
L
V
D
K
L
M
P
V
I
M
I
I
M
-
R
D
H
T
Y
A
K
C
Q
N
A
L
Q
Q
V
V
A
R
Q
G
R
P
V
V
I
C
D
K
E
D
T
E
T
I
K
N
T
-
K
R
T
I
--
K
-
V
P
H
S
V
D
C
L
Q
G
I
L
S
V
I
P
L
Q
L
L
A
F
H
L
A
V
L
R
G
Y
D
V
D
F
P
R
N
L
A
K
S
V
T
V
E
8
PsiBlast_PDB
72.93
40%
-102
- C2 -
1MOS
6
GLMS_ECOLI
A:
[5-368]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
N
T
L
TGR
I
S
H
G
-
Q
V
D
--
L
-----
S
E
L
G
P
-
N
A
D
---
E
L
L
S
K
V
E
------
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
-
L
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
-
G
L
D
A
S
-
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
-
D
-
K
R
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
-
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
-
Q
D
A
G
F
V
S
S
D
N
M
H
I
I
--
E
-
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
9
PsiBlast_PDB
72.34
40%
-104
- C2 -
1MOQ
9
GLMS_ECOLI
A:
[5-368]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
N
T
L
TGR
I
S
H
G
-
Q
V
D
--
L
-----
S
E
L
G
P
-
N
A
D
---
E
L
L
S
K
V
E
------
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
-
L
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
-
G
L
D
A
S
-
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
-
D
-
K
R
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
-
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
-
Q
D
A
G
F
V
S
S
D
N
M
H
I
I
--
E
-
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
10
PsiBlast_PDB
71.77
40%
-102
- C2 -
1MOR
1
GLMS_ECOLI
A:
[5-368]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
N
T
L
TGR
I
S
H
G
-
Q
V
D
--
L
-----
S
E
L
G
P
-
N
A
D
---
E
L
L
S
K
V
E
------
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
-
L
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
-
G
L
D
A
S
-
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
-
D
-
K
R
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
-
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
-
Q
D
A
G
F
V
S
S
D
N
M
H
I
I
--
E
-
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
5
PsiBlast_PDB
71.29
39%
-105
- C2 -
2VF5
1
GLMS_ECOLI
X:
[243-608]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
N
T
LTGR
I
S
H
G
-
Q
V
D
--
L
-----
S
E
L
G
P
-
N
A
D
---
E
L
L
S
K
V
E
------
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
-
L
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
-
L
D
A
S
-
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
-
D
-
K
R
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
-
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
-
Q
D
A
G
F
V
S
S
D
N
M
H
I
I
--
E
-
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
61
HHSearch
70.64
36%
-100
* C2 *
2ZJ3
1
GFPT1_HUMAN
A:
[11-375]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
G
N
F
S
S
F
M
Q
K
E
I
F
E
Q
P
-
E
S
V
V
N
T
----
M
R
G
R
-
V
N
F
--
D
DYTVN
L
G
G
L
K
-
D
H
I
---
K
E
I
Q
R
C
R
------
R
L
I
L
I
A
C
G
T
S
Y
H
A
G
V
A
T
R
Q
V
L
E
E
L
T
E
L
P
V
M
V
E
L
A
S
D
F
L
D
R
N
T
P
V
F
R
D
D
V
C
F
F
L
S
Q
S
G
E
T
A
D
T
L
M
G
L
R
Y
C
K
E
R
G
A
-
L
-
T
V
G
I
T
N
T
V
G
S
S
I
S
R
E
T
D
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
F
V
S
L
V
M
F
A
L
M
M
C
D
D
R
I
S
M
Q
-
E
-
R
R
K
E
I
M
L
G
L
K
R
L
P
D
L
I
K
E
V
L
S
M
D
D
-
E
-
I
Q
K
L
A
T
E
L
Y
H
Q
K
S
V
L
I
M
G
R
G
Y
H
Y
A
T
C
L
E
G
A
L
K
I
K
E
I
T
Y
M
H
S
E
G
I
L
A
G
E
L
K
H
G
P
L
A
L
V
D
K
L
M
P
V
I
M
I
I
M
-
R
D
H
T
Y
A
K
C
Q
N
A
L
Q
Q
V
V
A
R
Q
G
R
P
V
V
I
C
D
K
E
D
T
E
--
T
I
K
N
T
K
R
T
--
I
K
V
P
H
S
V
D
C
L
Q
G
I
L
S
V
I
P
L
Q
L
L
A
F
H
L
A
V
L
R
G
Y
D
V
D
F
P
R
N
L
A
K
S
V
T
V
E
66
HHSearch
70.29
39%
-103
- C2 -
1MOQ
9
GLMS_ECOLI
A:
[3-368]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
N
T
----
L
T
G
R
-
I
S
H
--
G
QVD--
L
S
E
L
G
P
N
A
D
---
E
L
L
S
K
V
E
------
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
C
D
V
E
I
A
S
E
F
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
G
-
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
-
A
S
-
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
-
R
-
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
-
N
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
Q
D
A
G
F
-
V
-
S
S
D
N
M
H
I
--
I
E
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
36
PsiBlast_CBE
66.35
34%
-94
- C2 -
2PUW
2
GFA1_CANAL
B:
[4-355]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
K
H
F
M
Q
K
E
I
F
E
Q
P
----
D
S
A
----
F
N
T
M
-
R
G
R
ID
F
-----
E
N
C
V
V
-
T
L
G
---
G
L
K
S
W
L
S
T
I
R
R
CR
R
I
I
M
I
A
C
G
T
S
Y
H
S
C
L
A
T
R
S
I
F
E
E
L
T
E
I
P
V
S
V
E
L
A
S
D
F
L
D
R
R
S
P
V
F
R
D
D
T
C
V
F
V
S
Q
S
G
E
T
A
D
S
I
L
A
L
Q
Y
C
L
E
R
G
A
-
L
-
T
V
G
I
V
N
S
V
G
S
S
M
S
R
Q
T
H
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
Y
I
A
L
V
M
F
A
L
S
L
S
N
--
D
S
I
S
R
K
G
R
H
E
E
I
I
K
G
L
Q
K
I
P
E
Q
I
K
Q
V
L
K
L
-
E
N
K
-
I
K
D
L
C
N
S
S
--
Q
K
S
L
L
L
L
G
R
G
Y
Q
F
A
T
A
L
E
G
A
L
K
I
K
E
I
S
Y
M
H
S
E
G
V
L
A
G
E
L
-----------
L
P
I
I
A
F
A
T
-
R
D
S
L
F
P
K
V
M
S
A
I
E
Q
V
T
A
R
D
G
R
P
I
V
I
C
N
E
G
D
-------
V
H
T
T
L
--
E
-
V
P
E
T
V
D
C
L
Q
G
L
L
N
V
I
P
L
Q
L
I
S
Y
W
L
A
V
N
R
G
I
D
V
D
------------
17
PsiBlast_PDB
65.30
34%
-95
- C2 -
2PUW
3
GFA1_CANAL
A:
[4-355]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
K
H
F
M
Q
K
E
I
F
E
Q
P
----
D
S
A
----
F
N
T
M
-
R
G
R
ID
F
-----
E
N
C
V
V
-
T
L
G
---
G
L
K
S
W
L
S
T
I
R
R
CR
R
I
I
M
I
A
C
G
T
S
Y
H
S
C
L
A
T
R
S
I
F
E
E
L
T
E
I
P
V
S
V
E
L
A
S
D
F
L
D
R
R
S
P
V
F
R
D
D
T
C
V
F
V
S
Q
S
G
E
T
A
D
S
I
L
A
L
Q
Y
C
L
E
R
G
A
-
L
-
T
V
G
I
V
N
S
V
G
S
S
M
S
R
Q
T
H
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
Y
I
A
L
V
M
F
A
L
S
L
S
N
--
D
S
I
S
R
K
G
R
H
E
E
I
I
K
G
L
Q
K
I
P
E
Q
I
K
Q
V
L
K
L
-
E
N
K
-
I
K
D
L
C
N
S
S
--
Q
K
S
L
L
L
L
G
R
G
Y
Q
F
A
T
A
L
E
G
A
L
K
I
K
E
I
S
Y
M
H
S
E
G
V
L
A
G
E
L
---------
E
D
L
P
I
I
A
F
A
T
-
R
D
S
L
F
P
K
V
M
S
A
I
E
Q
V
T
A
R
D
G
R
P
I
V
I
C
N
E
G
D
A
I
I
S
N
D
K
V
H
T
T
L
--
E
-
V
P
E
T
V
D
C
L
Q
G
L
L
N
V
I
P
L
Q
L
I
S
Y
W
L
A
V
N
R
G
I
D
V
D
------------
90
Fugue
50.58
37%
-108
- C2 -
1MOQ
7
?
?:
[186-368]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
-
L
P
S
R
I
E
Q
M
L
S
Q
D
--------
K
R
-
I
-
E
---
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N-
N
E
L
L
E
K
L
K
S
N
I
E
E
V
R
A
R
G
G
Q
L
Y
V
F
A
D
Q
D
A
G
F
V
S
S
D
N
M
H
I
I
E
MP
H
-
V
E
---
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E