@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0227: (2015-11-29 )
MLPDKIIYEGKAKFIIETKDPLTVIQYFKDEVTAFNKEKYKIIEGKGTINNRISTFIMETLEKAGINTHFIKTLSEREQLVKKLKIIPLEIVVRNIAAGSFCKRFNIKEGEKLAFPIIEFFYKNDGLADPMVNENHVLYFGWLSYEEMEEIKTITIKINTVLIDLFLNAGIDLVDLKLEFGRPINDNTKITLADEISPDNCRLWDKNTHKKLDKDVFRLNLGNLKEAYLEVAKRLSVKLC
Atome Classification :
(32 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180....-.---..190.......200.......210.......220.......230.......240
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLPD
K
I
I
YEG
K
A
K
F
I
I
ETKD
P
L
T
V
I
Q
Y
F
K
D
E
V
T
AFNK
E
K
Y
K
I
I
EGKGTI
N
N
R
I
S
T
F
I
M
E
T
L
E
KAGI
N
T
H
F
I
K
T
L
S
E
R
E
Q
L
V
K
K
LKII
P
L
E
I
V
V
R
N
IAA
G
S
F
C
K
RFNIKEG
E
K
L
A
F
P
I
I
E
F
F
YKNDGLADPMVNEN
H
V
L
Y
F
GWL
S
Y
E
E
M
EE
I
K
T
I
T
I
K
I
N
T
V
L
I
D
L
F
L
NAGI
D
L
V
D
L
K
L
E
FGRPIND-N---T
K
I
T
L
ADEISPDN
C
R
LWDKN
T
H
K
K
L
D
K
D
V
F
R
LNLG
N
L
K
E
A
Y
L
E
V
A
K
R
LSVKLC
7
PsiBlast_PDB
92.52
46%
-82
- C2 -
2YZL
3
PUR7_METJA
A:
[8-241]
I
L
K
K
Q
P
L
Y
S
G
K
A
K
S
I
Y
E
I
D
D
D
K
V
L
I
E
-
F
R
D
D
I
T
A
G
-
G
A
K
H
D
V
K
Q
G
K
G
Y
L
N
A
L
I
S
S
K
L
F
E
A
L
E
E
N
G
V
K
T
H
Y
I
K
Y
I
E
P
R
Y
M
I
A
K
K
V
E
I
I
P
I
E
V
I
V
R
N
I
A
A
G
S
L
C
R
R
Y
P
F
E
E
G
K
E
L
P
F
P
I
V
Q
F
D
Y
K
N
D
E
Y
G
D
P
M
L
N
E
D
I
A
V
A
L
G
L
A
T
R
E
E
L
N
K
I
K
E
I
A
L
K
V
N
E
V
L
K
K
L
F
D
E
K
G
I
I
L
V
D
F
K
I
E
I
G
K
D
R
E
G
-
N
-----
L
L
V
A
D
E
I
S
P
D
T
M
R
L
W
D
K
E
T
R
D
V
L
D
K
D
V
F
R
K
D
L
G
D
V
I
A
K
Y
R
I
V
A
E
R
L
G
L
L
--
1
PsiBlast_PDB
92.47
59%
-84
- C2 -
3KRE
12
PUR7_EHRCR
A:
[28-259]
------
I
Y
E
G
K
A
K
I
I
F
A
T
L
N
P
L
E
V
I
Q
H
F
K
D
E
I
T
A
F
N
N
K
K
A
A
I
I
H
E
K
G
I
L
N
N
Y
I
S
S
F
L
M
K
K
L
I
D
K
G
I
K
T
H
F
I
S
L
L
N
Q
R
E
Q
L
V
K
K
I
T
I
I
P
I
E
V
V
I
R
N
L
A
A
G
N
F
S
K
R
F
Q
I
A
D
G
T
P
F
K
S
P
I
I
E
F
Y
Y
K
N
D
E
L
S
D
P
M
V
S
E
G
H
I
L
S
F
Q
W
L
T
N
Q
E
L
E
K
I
K
I
L
S
L
K
I
N
N
I
L
S
E
L
F
F
N
V
G
I
K
L
V
D
F
K
L
E
F
G
K
L
H
N
D
E
Q
---
S
D
L
F
L
A
D
E
I
S
P
D
T
C
R
L
W
D
I
S
T
N
K
R
L
D
K
D
R
Y
R
L
N
L
G
N
V
I
E
G
Y
R
E
V
A
H
K
L
N
A
I
P
N
34
HHSearch
91.88
58%
-82
- C2 -
3KRE
12
PUR7_EHRCR
A:
[26-261]
----
E
K
I
Y
E
G
K
A
K
I
I
F
A
T
L
N
P
L
E
V
I
Q
H
F
K
D
E
I
T
A
F
N
N
K
K
A
A
I
I
H
E
K
G
I
L
N
N
Y
I
S
S
F
L
M
K
K
L
I
D
K
G
I
K
T
H
F
I
S
L
L
N
Q
R
E
Q
L
V
K
K
I
T
I
I
P
I
E
V
V
I
R
N
L
A
A
G
N
F
S
K
R
F
Q
I
A
D
G
T
P
F
K
S
P
I
I
E
F
Y
Y
K
N
D
E
L
S
D
P
M
V
S
E
G
H
I
L
S
F
Q
W
L
T
N
Q
E
L
E
K
I
K
I
L
S
L
K
I
N
N
I
L
S
E
L
F
F
N
V
G
I
K
L
V
D
F
K
L
E
F
G
K
L
H
---
N
DEQ
S
D
L
F
L
A
D
E
I
S
P
D
T
C
R
L
W
D
I
S
T
N
K
R
L
D
K
D
R
Y
R
L
N
L
G
N
V
I
E
G
Y
R
E
V
A
H
K
L
N
A
I
P
N
36
HHSearch
91.73
48%
-77
- C2 -
2YWV
5
?
A:
[5-239]
-
T
K
Q
Q
L
L
Y
E
G
K
A
K
K
I
Y
A
T
D
E
P
D
V
L
W
V
E
Y
K
D
S
A
T
A
F
N
G
E
K
K
A
T
I
A
G
K
G
R
L
N
N
E
I
S
S
L
L
F
L
K
L
R
E
A
G
I
A
N
H
F
I
E
K
L
S
P
T
E
Q
L
V
R
R
V
T
I
I
P
L
E
V
V
V
R
N
V
V
A
G
S
L
A
K
R
I
G
L
E
E
G
T
P
L
E
A
P
L
V
E
F
Y
Y
K
N
D
D
L
G
D
P
L
L
L
E
D
H
I
F
I
L
K
L
A
S
R
E
E
V
A
A
L
K
Q
A
A
L
A
V
N
D
V
L
R
L
H
F
A
E
R
N
V
R
L
I
D
F
K
L
E
F
G
R
T
A
---
D
---
G
A
I
L
L
A
D
E
I
S
P
D
T
C
R
L
W
D
A
K
T
N
E
K
L
D
K
D
V
F
R
R
D
L
G
S
L
T
D
A
Y
E
V
I
L
Q
R
L
G
G
E
--
8
PsiBlast_PDB
90.88
46%
-83
- C2 -
2Z02
3
PUR7_METJA
A:
[8-241]
I
L
K
K
Q
P
L
Y
S
G
K
A
K
S
I
Y
E
I
D
D
D
K
V
L
I
E
-
F
R
D
D
I
T
A
G
N
G
A
K
H
D
V
K
Q
G
K
G
Y
L
N
A
L
I
S
S
K
L
F
E
A
L
E
E
N
G
V
K
T
H
Y
I
K
Y
I
E
P
R
Y
M
I
A
K
K
V
E
I
I
P
I
E
V
I
V
R
N
I
A
A
G
S
L
C
R
R
Y
P
F
E
E
G
K
E
L
P
F
P
I
V
Q
F
D
Y
K
N
D
E
Y
G
D
P
M
L
N
E
D
I
A
V
A
L
G
L
A
T
R
E
E
L
N
K
I
K
E
I
A
L
K
V
N
E
V
L
K
K
L
F
D
E
K
G
I
I
L
V
D
F
K
I
E
I
G
K
D
R
E
G
-
N
-----
L
L
V
A
D
E
I
S
P
D
T
M
R
L
W
D
K
E
T
R
D
V
L
D
K
D
V
F
R
K
D
L
G
D
V
I
A
K
Y
R
I
V
A
E
R
L
G
L
L
--
26
PsiBlast_CBE
90.56
46%
-82
- C2 -
2Z02
4
PUR7_METJA
B:
[8-241]
I
L
K
K
Q
P
L
Y
S
G
K
A
K
S
I
Y
E
I
D
D
D
K
V
L
I
E
-
F
R
D
D
I
T
A
G
N
G
A
K
H
D
V
K
Q
G
K
G
Y
L
N
A
L
I
S
S
K
L
F
E
A
L
E
E
N
G
V
K
T
H
Y
I
K
Y
I
E
P
R
Y
M
I
A
K
K
V
E
I
I
P
I
E
V
I
V
R
N
I
A
A
G
S
L
C
R
R
Y
P
F
E
E
G
K
E
L
P
F
P
I
V
Q
F
D
Y
K
N
D
E
Y
G
D
P
M
L
N
E
D
I
A
V
A
L
G
L
A
T
R
E
E
L
N
K
I
K
E
I
A
L
K
V
N
E
V
L
K
K
L
F
D
E
K
G
I
I
L
V
D
F
K
I
E
I
G
K
D
R
E
G
-
N
-----
L
L
V
A
D
E
I
S
P
D
T
M
R
L
W
D
K
E
T
R
D
V
L
D
K
D
V
F
R
K
D
L
G
D
V
I
A
K
Y
R
I
V
A
E
R
L
G
L
L
--
33
HHSearch
90.16
47%
-80
* C2 *
2GQR
2
PUR7_ECOLI
A:
[1-236]
M
Q
K
Q
A
E
L
Y
R
G
K
A
K
T
V
Y
S
T
E
N
P
D
L
L
V
L
E
F
R
N
D
T
S
A
G
D
G
A
R
I
E
Q
F
D
R
K
G
M
V
N
N
K
F
N
Y
F
I
M
S
K
L
A
E
A
G
I
P
T
Q
M
E
R
L
L
S
D
T
E
C
L
V
K
K
L
D
M
V
P
V
E
C
V
V
R
N
R
A
A
G
S
L
V
K
R
L
G
I
E
E
G
I
E
L
N
P
P
L
F
D
L
F
L
K
N
D
A
M
H
D
P
M
V
N
E
S
Y
C
E
T
F
G
W
V
S
K
E
N
L
A
R
M
K
E
L
T
Y
K
A
N
D
V
L
K
K
L
F
D
D
A
G
L
I
L
V
D
F
K
L
E
F
G
L
Y
K
-------
G
E
V
V
L
G
D
E
F
S
P
D
G
S
R
L
W
D
K
E
T
L
E
K
M
D
K
D
R
F
R
Q
S
L
G
G
L
I
E
A
Y
E
A
V
A
R
R
L
G
V
Q
L
D
41
Fugue
90.15
46%
-74
- C2 -
2GQS
6
PUR7_ECOLI
A:
[1-237]
M
Q
K
Q
A
E
L
Y
R
G
K
A
K
T
V
Y
S
T
E
N
P
D
L
L
V
L
E
F
R
N
D
T
S
A
G
D
G
A
R
I
E
Q
F
D
R
K
G
M
V
N
N
K
F
N
Y
F
I
M
S
K
L
A
E
A
G
I
P
T
Q
M
E
R
L
L
S
D
T
E
C
L
V
K
K
L
D
M
V
P
V
E
C
V
V
R
N
R
A
A
G
S
L
V
K
R
L
G
I
E
E
G
I
E
L
N
P
P
L
F
D
L
F
L
K
N
D
A
M
H
D
P
M
V
N
E
S
Y
C
E
T
F
G
W
V
S
K
E
N
L
A
R
M
K
E
L
T
Y
K
A
N
D
V
L
K
K
L
F
D
D
A
G
L
I
L
V
D
F
K
L
E
F
G
L
Y
----
K
---
G
E
V
V
L
G
D
E
F
S
P
D
G
S
R
L
W
D
K
E
T
L
E
K
M
D
K
D
R
F
R
Q
S
L
G
G
L
I
E
A
Y
E
A
V
A
R
R
L
G
V
Q
L
D
3
PsiBlast_PDB
89.94
48%
-81
- C2 -
2YWV
5
?
A:
[8-237]
----
Q
L
L
Y
E
G
K
A
K
K
I
Y
A
T
D
E
P
D
V
L
W
V
E
Y
K
D
S
A
T
A
F
N
G
E
K
K
A
T
I
A
G
K
G
R
L
N
N
E
I
S
S
L
L
F
L
K
L
R
E
A
G
I
A
N
H
F
I
E
K
L
S
P
T
E
Q
L
V
R
R
V
T
I
I
P
L
E
V
V
V
R
N
V
V
A
G
S
L
A
K
R
I
G
L
E
E
G
T
P
L
E
A
P
L
V
E
F
Y
Y
K
N
D
D
L
G
D
P
L
L
L
E
D
H
I
F
I
L
K
L
A
S
R
E
E
V
A
A
L
K
Q
A
A
L
A
V
N
D
V
L
R
L
H
F
A
E
R
N
V
R
L
I
D
F
K
L
E
F
G
R
--
T
A
-
D
---
G
A
I
L
L
A
D
E
I
S
P
D
T
C
R
L
W
D
A
K
T
N
E
K
L
D
K
D
V
F
R
R
D
L
G
S
L
T
D
A
Y
E
V
I
L
Q
R
L
G
G
E
--
32
HHSearch
89.69
46%
-81
- C2 -
2Z02
3
PUR7_METJA
A:
[8-242]
I
L
K
K
Q
P
L
Y
S
G
K
A
K
S
I
Y
E
I
D
-
D
D
K
V
L
I
E
F
R
D
D
I
T
A
G
N
G
A
K
H
D
V
K
Q
G
K
G
Y
L
N
A
L
I
S
S
K
L
F
E
A
L
E
E
N
G
V
K
T
H
Y
I
K
Y
I
E
P
R
Y
M
I
A
K
K
V
E
I
I
P
I
E
V
I
V
R
N
I
A
A
G
S
L
C
R
R
Y
P
F
E
E
G
K
E
L
P
F
P
I
V
Q
F
D
Y
K
N
D
E
Y
G
D
P
M
L
N
E
D
I
A
V
A
L
G
L
A
T
R
E
E
L
N
K
I
K
E
I
A
L
K
V
N
E
V
L
K
K
L
F
D
E
K
G
I
I
L
V
D
F
K
I
E
I
G
K
D
R
---
E
---
G
N
L
L
V
A
D
E
I
S
P
D
T
M
R
L
W
D
K
E
T
R
D
V
L
D
K
D
V
F
R
K
D
L
G
D
V
I
A
K
Y
R
I
V
A
E
R
L
G
L
L
--
11
PsiBlast_PDB
89.49
46%
-75
- C2 -
4O7L
4
PUR7_PYRHO
A:
[7-232]
------
V
Y
E
G
K
A
K
K
M
I
P
I
D
D
D
K
L
I
M
E
-
F
K
D
D
A
T
A
F
D
G
T
K
K
A
R
F
K
G
K
G
W
L
N
A
Q
L
S
V
I
F
F
K
L
L
E
E
H
G
I
K
T
H
F
I
G
V
A
G
G
N
R
L
I
V
E
K
L
D
M
Y
P
L
E
V
V
V
R
N
V
V
A
G
S
L
K
K
R
L
P
L
P
E
G
Y
E
L
P
E
P
I
V
E
L
Y
Y
K
N
D
E
L
H
D
P
M
I
N
Y
Y
H
A
K
V
L
G
-
I
S
L
D
E
I
K
K
I
E
E
I
A
L
K
V
N
E
I
L
K
D
Y
L
A
K
K
G
I
I
L
V
D
F
K
L
E
F
G
K
--
D
K
-
N
---
G
D
I
V
L
A
D
E
I
S
P
D
T
C
R
F
W
D
A
K
T
K
R
S
L
D
K
D
V
F
R
F
D
K
G
D
L
I
E
A
Y
K
E
I
Y
E
R
I
T
G
E
K
P
22
PsiBlast_CBE
89.48
48%
-79
- C2 -
2YWV
5
?
B:
[8-237]
----
Q
L
L
Y
E
G
K
A
K
K
I
Y
A
T
D
E
P
D
V
L
W
V
E
Y
K
D
S
A
T
A
F
N
G
E
K
K
A
T
I
A
G
K
G
R
L
N
N
E
I
S
S
L
L
F
L
K
L
R
E
A
G
I
A
N
H
F
I
E
K
L
S
P
T
E
Q
L
V
R
R
V
T
I
I
P
L
E
V
V
V
R
N
V
V
A
G
S
L
A
K
R
I
G
L
E
E
G
T
P
L
E
A
P
L
V
E
F
Y
Y
K
N
D
D
L
G
D
P
L
L
L
E
D
H
I
F
I
L
K
L
A
S
R
E
E
V
A
A
L
K
Q
A
A
L
A
V
N
D
V
L
R
L
H
F
A
E
R
N
V
R
L
I
D
F
K
L
E
F
G
R
--
T
A
-
D
---
G
A
I
L
L
A
D
E
I
S
P
D
T
C
R
L
W
D
A
K
T
N
E
K
L
D
K
D
V
F
R
R
D
L
G
S
L
T
D
A
Y
E
V
I
L
Q
R
L
G
G
E
--
12
PsiBlast_PDB
89.32
46%
-75
- C2 -
4O7N
4
PUR7_PYRHO
A:
[7-232]
------
V
Y
E
G
K
A
K
K
M
I
P
I
D
D
D
K
L
I
M
E
-
F
K
D
D
A
T
A
F
D
G
T
K
K
A
R
F
K
G
K
G
W
L
N
A
Q
L
S
V
I
F
F
K
L
L
E
E
H
G
I
K
T
H
F
I
G
V
A
G
G
N
R
L
I
V
E
K
L
D
M
Y
P
L
E
V
V
V
R
N
V
V
A
G
S
L
K
K
R
L
P
L
P
E
G
Y
E
L
P
E
P
I
V
E
L
Y
Y
K
N
D
E
L
H
D
P
M
I
N
Y
Y
H
A
K
V
L
G
-
I
S
L
D
E
I
K
K
I
E
E
I
A
L
K
V
N
E
I
L
K
D
Y
L
A
K
K
G
I
I
L
V
D
F
K
L
E
F
G
K
--
D
K
-
N
---
G
D
I
V
L
A
D
E
I
S
P
D
T
C
R
F
W
D
A
K
T
K
R
S
L
D
K
D
V
F
R
F
D
K
G
D
L
I
E
A
Y
K
E
I
Y
E
R
I
T
G
E
K
P
17
PsiBlast_PDB
88.75
46%
-74
- C2 -
4O7W
4
PUR7_PYRHO
A:
[7-232]
------
V
Y
E
G
K
A
K
K
M
I
P
I
D
D
D
K
L
I
M
E
-
F
K
D
D
A
T
A
F
D
G
T
K
K
A
R
F
K
G
K
G
W
L
N
A
Q
L
S
V
I
F
F
K
L
L
E
E
H
G
I
K
T
H
F
I
G
V
A
G
G
N
R
L
I
V
E
K
L
D
M
Y
P
L
E
V
V
V
R
N
V
V
A
G
S
L
K
K
R
L
P
L
P
E
G
Y
E
L
P
E
P
I
V
E
L
Y
Y
K
N
D
E
L
H
D
P
M
I
N
Y
Y
H
A
K
V
L
G
-
I
S
L
D
E
I
K
K
I
E
E
I
A
L
K
V
N
E
I
L
K
D
Y
L
A
K
K
G
I
I
L
V
D
F
K
L
E
F
G
K
--
D
K
-
N
---
G
D
I
V
L
A
D
E
I
S
P
D
T
C
R
F
W
D
A
K
T
K
R
S
L
D
K
D
V
F
R
F
D
K
G
D
L
I
E
A
Y
K
E
I
Y
E
R
I
T
G
E
K
P
27
PsiBlast_CBE
88.67
46%
-76
- C2 -
2GQS
6
PUR7_ECOLI
B:
[7-236]
------
L
Y
R
G
K
A
K
T
V
Y
S
T
E
N
P
D
L
L
V
L
E
F
R
N
D
T
S
A
G
D
G
A
R
I
E
Q
F
D
R
K
G
M
V
N
N
K
F
N
Y
F
I
M
S
K
L
A
E
A
G
I
P
T
Q
M
E
R
L
L
S
D
T
E
C
L
V
K
K
L
D
M
V
P
V
E
C
V
V
R
N
R
A
A
G
S
L
V
K
R
L
G
I
E
E
G
I
E
L
N
P
P
L
F
D
L
F
L
K
N
D
A
M
H
D
P
M
V
N
E
S
Y
C
E
T
F
G
W
V
S
K
E
N
L
A
R
M
K
E
L
T
Y
K
A
N
D
V
L
K
K
L
F
D
D
A
G
L
I
L
V
D
F
K
L
E
F
G
L
Y
----
K
---
G
E
V
V
L
G
D
E
F
S
P
D
G
S
R
L
W
D
K
E
T
L
E
K
M
D
K
D
R
F
R
Q
S
L
G
G
L
I
E
A
Y
E
A
V
A
R
R
L
G
V
Q
L
D
20
PsiBlast_PDB
88.48
45%
-79
- C2 -
2GQR
2
PUR7_ECOLI
A:
[7-236]
------
L
Y
R
G
K
A
K
T
V
Y
S
T
E
N
P
D
L
L
V
L
E
F
R
N
D
T
S
A
G
D
G
A
R
I
E
Q
F
D
R
K
G
M
V
N
N
K
F
N
Y
F
I
M
S
K
L
A
E
A
G
I
P
T
Q
M
E
R
L
L
S
D
T
E
C
L
V
K
K
L
D
M
V
P
V
E
C
V
V
R
N
R
A
A
G
S
L
V
K
R
L
G
I
E
E
G
I
E
L
N
P
P
L
F
D
L
F
L
K
N
D
A
M
H
D
P
M
V
N
E
S
Y
C
E
T
F
G
W
V
S
K
E
N
L
A
R
M
K
E
L
T
Y
K
A
N
D
V
L
K
K
L
F
D
D
A
G
L
I
L
V
D
F
K
L
E
F
G
L
Y
----
K
---
G
E
V
V
L
G
D
E
F
S
P
D
G
S
R
L
W
D
K
E
T
L
E
K
M
D
K
D
R
F
R
Q
S
L
G
G
L
I
E
A
Y
E
A
V
A
R
R
L
G
V
Q
L
D
9
PsiBlast_PDB
87.88
46%
-74
- C2 -
2GQS
6
PUR7_ECOLI
A:
[7-236]
------
L
Y
R
G
K
A
K
T
V
Y
S
T
E
N
P
D
L
L
V
L
E
F
R
N
D
T
S
A
G
D
G
A
R
I
E
Q
F
D
R
K
G
M
V
N
N
K
F
N
Y
F
I
M
S
K
L
A
E
A
G
I
P
T
Q
M
E
R
L
L
S
D
T
E
C
L
V
K
K
L
D
M
V
P
V
E
C
V
V
R
N
R
A
A
G
S
L
V
K
R
L
G
I
E
E
G
I
E
L
N
P
P
L
F
D
L
F
L
K
N
D
A
M
H
D
P
M
V
N
E
S
Y
C
E
T
F
G
W
V
S
K
E
N
L
A
R
M
K
E
L
T
Y
K
A
N
D
V
L
K
K
L
F
D
D
A
G
L
I
L
V
D
F
K
L
E
F
G
L
Y
----
K
---
G
E
V
V
L
G
D
E
F
S
P
D
G
S
R
L
W
D
K
E
T
L
E
K
M
D
K
D
R
F
R
Q
S
L
G
G
L
I
E
A
Y
E
A
V
A
R
R
L
G
V
Q
L
D
21
PsiBlast_CBE
87.80
48%
-81
- C2 -
3NUA
3
PUR7_CLOP1
B:
[9-236]
----
E
M
L
Y
E
G
K
A
K
K
I
Y
A
T
D
K
E
D
M
V
I
V
H
Y
K
D
D
A
T
A
F
N
G
E
K
K
A
Q
I
E
S
K
G
V
L
N
N
E
I
T
S
L
I
F
E
M
L
N
K
E
G
I
K
T
H
F
V
E
K
L
N
D
R
D
Q
L
C
K
K
V
E
I
V
P
L
E
V
I
V
R
N
V
A
A
G
S
M
A
K
R
L
G
L
E
E
G
Y
E
L
K
T
T
V
F
E
L
S
Y
K
D
D
S
L
G
D
P
L
I
N
D
Y
H
A
V
G
I
G
A
T
T
F
E
E
L
N
K
I
Y
E
I
T
A
K
V
N
E
I
L
K
E
A
F
K
K
Q
N
I
N
L
I
D
F
K
L
E
F
G
R
Y
----
N
---
G
E
I
L
L
A
D
E
I
S
P
D
T
C
R
F
W
D
A
T
T
G
E
K
M
D
K
D
R
F
R
R
D
M
G
N
V
I
N
G
Y
R
E
V
L
N
R
L
R
N
---
31
HHSearch
87.66
48%
-83
- C2 -
3NUA
4
PUR7_CLOP1
A:
[5-237]
V
N
Q
L
E
M
L
Y
E
G
K
A
K
K
I
Y
A
T
D
K
E
D
M
V
I
V
H
Y
K
D
D
A
T
A
F
N
G
E
K
K
A
Q
I
E
S
K
G
V
L
N
N
E
I
T
S
L
I
F
E
M
L
N
K
E
G
I
K
T
H
F
V
E
K
L
N
D
R
D
Q
L
C
K
K
V
E
I
V
P
L
E
V
I
V
R
N
V
A
A
G
S
M
A
K
R
L
G
L
E
E
G
Y
E
L
K
T
T
V
F
E
L
S
Y
K
D
D
S
L
G
D
P
L
I
N
D
Y
H
A
V
G
I
G
A
T
T
F
E
E
L
N
K
I
Y
E
I
T
A
K
V
N
E
I
L
K
E
A
F
K
K
Q
N
I
N
L
I
D
F
K
L
E
F
G
R
Y
N
-------
G
E
I
L
L
A
D
E
I
S
P
D
T
C
R
F
W
D
A
T
T
G
E
K
M
D
K
D
R
F
R
R
D
M
G
N
V
I
N
G
Y
R
E
V
L
N
R
L
R
N
---
18
PsiBlast_PDB
87.15
46%
-78
- C2 -
4O7Y
3
PUR7_PYRHO
A:
[11-232]
----------
K
A
K
K
M
I
P
I
D
D
D
K
L
I
M
E
-
F
K
D
D
A
T
A
F
D
G
T
K
K
A
R
F
K
G
K
G
W
L
N
A
Q
L
S
V
I
F
F
K
L
L
E
E
H
G
I
K
T
H
F
I
G
V
A
G
G
N
R
L
I
V
E
K
L
D
M
Y
P
L
E
V
V
V
R
N
V
V
A
G
S
L
K
K
R
L
P
L
P
E
G
Y
E
L
P
E
P
I
V
E
L
Y
Y
K
N
D
E
L
H
D
P
M
I
N
Y
Y
H
A
K
V
L
G
-
I
S
L
D
E
I
K
K
I
E
E
I
A
L
K
V
N
E
I
L
K
D
Y
L
A
K
K
G
I
I
L
V
D
F
K
L
E
F
G
K
--
D
K
-
N
---
G
D
I
V
L
A
D
E
I
S
P
D
T
C
R
F
W
D
A
K
T
K
R
S
L
D
K
D
V
F
R
F
D
K
G
D
L
I
E
A
Y
K
E
I
Y
E
R
I
T
G
E
K
P
16
PsiBlast_PDB
87.08
46%
-76
- C2 -
4O7V
4
PUR7_PYRHO
A:
[11-232]
----------
K
A
K
K
M
I
P
I
D
D
D
K
L
I
M
E
-
F
K
D
D
A
T
A
F
D
G
T
K
K
A
R
F
K
G
K
G
W
L
N
A
Q
L
S
V
I
F
F
K
L
L
E
E
H
G
I
K
T
H
F
I
G
V
A
G
G
N
R
L
I
V
E
K
L
D
M
Y
P
L
E
V
V
V
R
N
V
V
A
G
S
L
K
K
R
L
P
L
P
E
G
Y
E
L
P
E
P
I
V
E
L
Y
Y
K
N
D
E
L
H
D
P
M
I
N
Y
Y
H
A
K
V
L
G
-
I
S
L
D
E
I
K
K
I
E
E
I
A
L
K
V
N
E
I
L
K
D
Y
L
A
K
K
G
I
I
L
V
D
F
K
L
E
F
G
K
--
D
K
-
N
---
G
D
I
V
L
A
D
E
I
S
P
D
T
C
R
F
W
D
A
K
T
K
R
S
L
D
K
D
V
F
R
F
D
K
G
D
L
I
E
A
Y
K
E
I
Y
E
R
I
T
G
E
K
P
14
PsiBlast_PDB
87.01
46%
-85
- C2 -
4O7S
3
PUR7_PYRHO
A:
[15-232]
--------------
M
I
P
I
D
D
D
K
L
I
M
E
-
F
K
D
D
A
T
A
F
D
G
T
K
K
A
R
F
K
G
K
G
W
L
N
A
Q
L
S
V
I
F
F
K
L
L
E
E
H
G
I
K
T
H
F
I
G
V
A
G
G
N
R
L
I
V
E
K
L
D
M
Y
P
L
E
V
V
V
R
N
V
V
A
G
S
L
K
K
R
L
P
L
P
E
G
Y
E
L
P
E
P
I
V
E
L
Y
Y
K
N
D
E
L
H
D
P
M
I
N
Y
Y
H
A
K
V
L
G
-
I
S
L
D
E
I
K
K
I
E
E
I
A
L
K
V
N
E
I
L
K
D
Y
L
A
K
K
G
I
I
L
V
D
F
K
L
E
F
G
K
--
D
K
-
N
---
G
D
I
V
L
A
D
E
I
S
P
D
T
C
R
F
W
D
A
K
T
K
R
S
L
D
K
D
V
F
R
F
D
K
G
D
L
I
E
A
Y
K
E
I
Y
E
R
I
T
G
E
K
P
13
PsiBlast_PDB
86.84
46%
-73
- C2 -
4O7R
5
PUR7_PYRHO
A:
[11-232]
----------
K
A
K
K
M
I
P
I
D
D
D
K
L
I
M
E
-
F
K
D
D
A
T
A
F
D
G
T
K
K
A
R
F
K
G
K
G
W
L
N
A
Q
L
S
V
I
F
F
K
L
L
E
E
H
G
I
K
T
H
F
I
G
V
A
G
G
N
R
L
I
V
E
K
L
D
M
Y
P
L
E
V
V
V
R
N
V
V
A
G
S
L
K
K
R
L
P
L
P
E
G
Y
E
L
P
E
P
I
V
E
L
Y
Y
K
N
D
E
L
H
D
P
M
I
N
Y
Y
H
A
K
V
L
G
-
I
S
L
D
E
I
K
K
I
E
E
I
A
L
K
V
N
E
I
L
K
D
Y
L
A
K
K
G
I
I
L
V
D
F
K
L
E
F
G
K
--
D
K
-
N
---
G
D
I
V
L
A
D
E
I
S
P
D
T
C
R
F
W
D
A
K
T
K
R
S
L
D
K
D
V
F
R
F
D
K
G
D
L
I
E
A
Y
K
E
I
Y
E
R
I
T
G
E
K
P
4
PsiBlast_PDB
86.74
48%
-83
- C2 -
4FE2
8
PUR7_STRPN
A:
[23-252]
---
K
Q
L
I
Y
S
G
K
A
K
D
I
Y
T
T
E
D
E
N
L
I
I
S
T
Y
K
D
Q
A
T
A
F
N
G
V
K
K
E
Q
I
A
G
K
G
V
L
N
N
Q
I
S
S
F
I
F
E
K
L
N
V
A
G
V
A
T
H
F
V
E
K
L
S
D
T
E
Q
L
N
K
K
V
K
I
I
P
L
E
V
V
L
R
N
Y
T
A
G
S
F
S
K
R
F
G
V
D
E
G
I
A
L
E
T
P
I
V
E
F
Y
Y
K
N
D
D
L
D
D
P
F
I
N
D
E
H
V
K
F
L
Q
I
A
G
D
Q
Q
I
A
Y
L
K
E
E
T
R
R
I
N
E
L
L
K
V
W
F
A
E
I
G
L
K
L
I
D
F
K
L
E
F
G
--
F
D
K
-
D
---
G
K
I
I
L
A
D
E
F
S
P
D
N
C
R
L
W
D
A
D
G
N
-
H
M
D
K
D
V
F
R
R
G
L
G
E
L
T
D
V
Y
E
I
V
W
E
K
L
Q
E
L
K
-
5
PsiBlast_PDB
86.57
48%
-80
- C2 -
4FGR
4
PUR7_STRPN
A:
[21-252]
-
M
S
K
Q
L
I
Y
S
G
K
A
K
D
I
Y
T
T
E
D
E
N
L
I
I
S
T
Y
K
D
Q
A
T
A
F
N
G
V
K
K
E
Q
I
A
G
K
G
V
L
N
N
Q
I
S
S
F
I
F
E
K
L
N
V
A
G
V
A
T
H
F
V
E
K
L
S
D
T
E
Q
L
N
K
K
V
K
I
I
P
L
E
V
V
L
R
N
Y
T
A
G
S
F
S
K
R
F
G
V
D
E
G
I
A
L
E
T
P
I
V
E
F
Y
Y
K
N
D
D
L
D
D
P
F
I
N
D
E
H
V
K
F
L
Q
I
A
G
D
Q
Q
I
A
Y
L
K
E
E
T
R
R
I
N
E
L
L
K
V
W
F
A
E
I
G
L
K
L
I
D
F
K
L
E
F
G
--
F
D
K
-
D
---
G
K
I
I
L
A
D
E
F
S
P
D
N
C
R
L
W
D
A
D
G
N
-
H
M
D
K
D
V
F
R
R
G
L
G
E
L
T
D
V
Y
E
I
V
W
E
K
L
Q
E
L
K
-
25
PsiBlast_CBE
86.26
48%
-82
- C2 -
4FE2
5
PUR7_STRPN
B:
[21-252]
-
M
S
K
Q
L
I
Y
S
G
K
A
K
D
I
Y
T
T
E
D
E
N
L
I
I
S
T
Y
K
D
Q
A
T
A
F
N
G
V
K
K
E
Q
I
A
G
K
G
V
L
N
N
Q
I
S
S
F
I
F
E
K
L
N
V
A
G
V
A
T
H
F
V
E
K
L
S
D
T
E
Q
L
N
K
K
V
K
I
I
P
L
E
V
V
L
R
N
Y
T
A
G
S
F
S
K
R
F
G
V
D
E
G
I
A
L
E
T
P
I
V
E
F
Y
Y
K
N
D
D
L
D
D
P
F
I
N
D
E
H
V
K
F
L
Q
I
A
G
D
Q
Q
I
A
Y
L
K
E
E
T
R
R
I
N
E
L
L
K
V
W
F
A
E
I
G
L
K
L
I
D
F
K
L
E
F
G
--
F
D
K
-
D
---
G
K
I
I
L
A
D
E
F
S
P
D
N
C
R
L
W
D
A
D
G
N
-
H
M
D
K
D
V
F
R
R
G
L
G
E
L
T
D
V
Y
E
I
V
W
E
K
L
Q
E
L
K
-
19
PsiBlast_PDB
86.15
46%
-81
- C2 -
4O86
6
PUR7_PYRHO
A:
[12-232]
-----------
A
K
K
M
I
P
I
D
D
D
K
L
I
M
E
-
F
K
D
D
A
T
A
F
D
G
T
K
K
A
R
F
K
G
K
G
W
L
N
A
Q
L
S
V
I
F
F
K
L
L
E
E
H
G
I
K
T
H
F
I
G
V
A
G
G
N
R
L
I
V
E
K
L
D
M
Y
P
L
E
V
V
V
R
N
V
V
A
G
S
L
K
K
R
L
P
L
P
E
G
Y
E
L
P
E
P
I
V
E
L
Y
Y
K
N
D
E
L
H
D
P
M
I
N
Y
Y
H
A
K
V
L
G
-
I
S
L
D
E
I
K
K
I
E
E
I
A
L
K
V
N
E
I
L
K
D
Y
L
A
K
K
G
I
I
L
V
D
F
K
L
E
F
G
K
--
D
K
-
N
---
G
D
I
V
L
A
D
E
I
S
P
D
T
C
R
F
W
D
A
K
T
K
R
S
L
D
K
D
V
F
R
F
D
K
G
D
L
I
E
A
Y
K
E
I
Y
E
R
I
T
G
E
K
P
2
PsiBlast_PDB
86.05
48%
-82
- C2 -
3NUA
4
PUR7_CLOP1
A:
[9-236]
----
E
M
L
Y
E
G
K
A
K
K
I
Y
A
T
D
K
E
D
M
V
I
V
H
Y
K
D
D
A
T
A
F
N
G
E
K
K
A
Q
I
E
S
K
G
V
L
N
N
E
I
T
S
L
I
F
E
M
L
N
K
E
G
I
K
T
H
F
V
E
K
L
N
D
R
D
Q
L
C
K
K
V
E
I
V
P
L
E
V
I
V
R
N
V
A
A
G
S
M
A
K
R
L
G
L
E
E
G
Y
E
L
K
T
T
V
F
E
L
S
Y
K
D
D
S
L
G
D
P
L
I
N
D
Y
H
A
V
G
I
G
A
T
T
F
E
E
L
N
K
I
Y
E
I
T
A
K
V
N
E
I
L
K
E
A
F
K
K
Q
N
I
N
L
I
D
F
K
L
E
F
G
R
Y
----
N
---
G
E
I
L
L
A
D
E
I
S
P
D
T
C
R
F
W
D
A
T
T
G
E
K
M
D
K
D
R
F
R
R
D
M
G
N
V
I
N
G
Y
R
E
V
L
N
R
L
R
N
---
15
PsiBlast_PDB
85.79
46%
-80
- C2 -
4O7T
5
PUR7_PYRHO
A:
[12-232]
-----------
A
K
K
M
I
P
I
D
D
D
K
L
I
M
E
-
F
K
D
D
A
T
A
F
D
G
T
K
K
A
R
F
K
G
K
G
W
L
N
A
Q
L
S
V
I
F
F
K
L
L
E
E
H
G
I
K
T
H
F
I
G
V
A
G
G
N
R
L
I
V
E
K
L
D
M
Y
P
L
E
V
V
V
R
N
V
V
A
G
S
L
K
K
R
L
P
L
P
E
G
Y
E
L
P
E
P
I
V
E
L
Y
Y
K
N
D
E
L
H
D
P
M
I
N
Y
Y
H
A
K
V
L
G
-
I
S
L
D
E
I
K
K
I
E
E
I
A
L
K
V
N
E
I
L
K
D
Y
L
A
K
K
G
I
I
L
V
D
F
K
L
E
F
G
K
--
D
K
-
N
---
G
D
I
V
L
A
D
E
I
S
P
D
T
C
R
F
W
D
A
K
T
K
R
S
L
D
K
D
V
F
R
F
D
K
G
D
L
I
E
A
Y
K
E
I
Y
E
R
I
T
G
E
K
P
6
PsiBlast_PDB
85.08
48%
-81
- C2 -
4NYE
4
PUR7_STRPN
A:
[21-252]
-
M
S
K
Q
L
I
Y
S
G
K
A
K
D
I
Y
T
T
E
D
E
N
L
I
I
S
T
Y
K
D
Q
A
T
A
F
N
G
V
K
K
E
Q
I
A
G
K
G
V
L
N
N
Q
I
S
S
F
I
F
E
K
L
N
V
A
G
V
A
T
H
F
V
E
K
L
S
D
T
E
Q
L
N
K
K
V
K
I
I
P
L
E
V
V
L
R
N
Y
T
A
G
S
F
S
K
R
F
G
V
D
E
G
I
A
L
E
T
P
I
V
E
F
Y
Y
K
N
D
D
L
D
D
P
F
I
N
D
E
H
V
K
F
L
Q
I
A
G
D
Q
Q
I
A
Y
L
K
E
E
T
R
R
I
N
E
L
L
K
V
W
F
A
E
I
G
L
K
L
I
D
F
K
L
E
F
G
--
F
D
K
-
D
---
G
K
I
I
L
A
D
E
F
S
P
D
N
C
R
L
W
D
A
D
G
N
-
H
M
D
K
D
V
F
R
R
G
L
G
E
L
T
D
V
Y
E
I
V
W
E
K
L
Q
E
L
K
-
24
PsiBlast_CBE
84.91
48%
-81
- C2 -
4FGR
4
PUR7_STRPN
B:
[22-252]
--
S
K
Q
L
I
Y
S
G
K
A
K
D
I
Y
T
T
E
D
E
N
L
I
I
S
T
Y
K
D
Q
A
T
A
F
N
G
V
K
K
E
Q
I
A
G
K
G
V
L
N
N
Q
I
S
S
F
I
F
E
K
L
N
V
A
G
V
A
T
H
F
V
E
K
L
S
D
T
E
Q
L
N
K
K
V
K
I
I
P
L
E
V
V
L
R
N
Y
T
A
G
S
F
S
K
R
F
G
V
D
E
G
I
A
L
E
T
P
I
V
E
F
Y
Y
K
N
D
D
L
D
D
P
F
I
N
D
E
H
V
K
F
L
Q
I
A
G
D
Q
Q
I
A
Y
L
K
E
E
T
R
R
I
N
E
L
L
K
V
W
F
A
E
I
G
L
K
L
I
D
F
K
L
E
F
G
--
F
D
K
-
D
---
G
K
I
I
L
A
D
E
F
S
P
D
N
C
R
L
W
D
A
D
G
N
-
H
M
D
K
D
V
F
R
R
G
L
G
E
L
T
D
V
Y
E
I
V
W
E
K
L
Q
E
L
--
23
PsiBlast_CBE
83.75
48%
-82
- C2 -
4NYE
4
PUR7_STRPN
B:
[22-252]
--
S
K
Q
L
I
Y
S
G
K
A
K
D
I
Y
T
T
E
D
E
N
L
I
I
S
T
Y
K
D
Q
A
T
A
F
N
G
V
K
K
E
Q
I
A
G
K
G
V
L
N
N
Q
I
S
S
F
I
F
E
K
L
N
V
A
G
V
A
T
H
F
V
E
K
L
S
D
T
E
Q
L
N
K
K
V
K
I
I
P
L
E
V
V
L
R
N
Y
T
A
G
S
F
S
K
R
F
G
V
D
E
G
I
A
L
E
T
P
I
V
E
F
Y
Y
K
N
D
D
L
D
D
P
F
I
N
D
E
H
V
K
F
L
Q
I
A
G
D
Q
Q
I
A
Y
L
K
E
E
T
R
R
I
N
E
L
L
K
V
W
F
A
E
I
G
L
K
L
I
D
F
K
L
E
F
G
--
F
D
K
-
D
---
G
K
I
I
L
A
D
E
F
S
P
D
N
C
R
L
W
D
A
D
G
N
-
H
M
D
K
D
V
F
R
R
G
L
G
E
L
T
D
V
Y
E
I
V
W
E
K
L
Q
E
L
--