@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0238: (2015-11-29 )
MFEWNTNNIIDATGGRGKSGCHNLNISTDTRNIKKGDLFIALKGKNFDGHDFLHEAFLKGAAAAVVSEDKYRNLPVIVVQDTLKALHDMASYYIRNVLVNAEVIAITGSVGKTTTKDMLHTVLSQYGVSHVNDGNLNNNIGLPLTILKAPENCRYLILEMGMNKAGEIKELSKISNPNIAVITNIEPVHVENFSSLFDIAQAKLEILYGVKNNGTLILNKDNKYYDYLLSHVDRDVVSFGRSESATVCLLNVIKNDKGLNLKIRLNNNQIMNCNLCVQGKHFVYSVLAVVAVIQNLGLNLSKLPLALENFNITKGRGSVHKAKYNGKCIHLIDDSYNASPASMKAAIRTLGIYSNRRKVALLGDMLELGNKSITFHMKLLDSIVKYDVDKVYTVGKFMLKLHRLLPGNIKGTHFNDSNQLKSNLANIVQNNDVVLVKGSRGVKMDFIVQGFIIEY
Atome Classification :
(20 SA)
.........10........-20........30........40........50........60........-70---..------.....-.-80-.......---------..90........100.------......110.......120.-..-..---------.--.130-....-----....--.140-...--..-----------------------------....--150..-----.....160.......170.......180.......190..-....-.200.-......-210.....-------..220-..-.....230-.-...-------...240.------------.-...-...250.......260....-.-..270-.......280.......290...--....300.......310....----...320.-..---...--..330........340---........350-----------.-...-.--...360.......370.--...--...380.--.....---.-----390.....-----------.------.400----.....--.--.-.--.410..------.....420......--.430-...----......440-...-....450...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MFEWNTN
N
I
I
DATGGRGKS-GC
H
N
L
N
ISTDTRNIKKG
D
L
F
I
A
L
KGKNFD
G
H
D
F
L
H
E
A
F
L
K
G
A
A
A
A
VVSED-KY---RN------L
P
V
I
V
-
V
-
Q
--
D
T
L
K
A
L
H
---------
D
M
A
S
Y
Y
I
R
N
V
LVN
A
E
V
------
I
A
I
TGSVGK
T
T
T
K
D
M
L
H
T
V
L
-
S
Q-YG---------V--SH---VNDG-----NLNN--NI---GL
P
--
L
T
-----------------------------
I
L
KA--PEN
C
R
-----
Y
L
I
L
EMGMNKAG
E
I
K
E
L
S
KISNP
N
I
A
V
I
TNIE
P
V
H
V
E
N
F
S
-
S
L
F
D
-
I
A
Q
A
K
-
L
E
I
L
Y
G-VKNN
G
T
L
I
-------LNKD
N
-
K
Y
-
Y
D
Y
L
L
S
H
V-
D
-
R
D
V
-------
V
SFGR-S------------E-S
A
T
-
V
C
L
L
N
V
IKNDKG
L
N
L
K
I
R
LN-N-
N
Q
I
M
N-C
N
L
C
VQG
K
H
F
V
Y
S
V
L
A
V
V
A
V
I
Q
N
--LGLN
L
S
KL
P
L
A
LENFNITKGR----GSVHK-A-KY---N
G
K
--
C
I
H
L
-IDDSYNAS
P
A
----
S
M
K
A
A
I
R
T
L
-G-----------I-YSN-R--
R
K
V
A
L
L
G
D
M
L
E
LGNK
S
I
--
T
F
H
--
M
K
L
L
D
S
I
--
V
K
Y
D
V
---
D
-----
K
V
Y
T
V
G
K
F
-----------
M
------
L
K
------
L
H
R
LL--P--G-N--IKGTHF------N
D
S
N
Q
L
K
S
N
L
A
N
I
V--QN---N
D
V
----
V
L
V
KGSRG
V
-
K
M
D
-
F
I
V
Q
G
F
I
IEY
4
PsiBlast_PDB
95.80
33%
-108
- C1 -
3ZM6
1
?
A:
[32-452]
-----------------------------
D
S
R
L
I
G
T
G
D
L
F
V
P
L
K
G
A
R
-
D
G
H
D
F
I
E
T
A
F
E
N
G
A
A
V
-
T
L
S
E
K
-
E
V
---
S
N
------
H
P
Y
I
L
-
V
-
D
--
D
V
L
T
A
F
Q
---------
S
L
A
S
Y
Y
L
E
K
T
T
V
D
--
V
------
F
A
V
T
G
S
N
G
K
T
T
T
K
D
M
L
A
H
L
L
-
S
T
-
R
Y
---------
K
--
T
Y
---
K
T
Q
G
-----
N
Y
N
N
--
E
I
---
G
L
P
--
Y
T
-----------------------------
V
L
H
M
--
P
E
G
T
E
-----
K
L
V
L
E
M
G
Q
D
H
L
G
D
I
H
L
L
S
E
L
A
R
P
K
T
A
I
V
T
L
V
G
E
A
H
L
A
F
F
K
-
D
R
S
E
-
I
A
K
G
K
-
M
Q
I
A
D
G
-
M
A
S
G
S
L
L
L
-------
A
P
A
D
P
-
I
V
-
E
D
Y
L
--
P
I
-
D
-
K
K
V
-------
V
R
F
G
Q
----------------
G
A
E
-
L
E
I
T
D
L
V
E
R
K
D
S
L
T
F
K
A
N
F
L
-
E
-
Q
A
L
----
D
L
P
V
T
G
K
Y
N
A
T
N
A
M
I
A
S
Y
V
A
L
Q
--
E
G
V
S
E
E
Q
I
R
L
A
F
Q
H
L
E
L
T
R
N
R
----
T
E
W
K
K
-
A
-
A
----
N
G
A
--
D
I
---
L
S
D
V
Y
N
A
N
P
T
----
A
M
K
L
I
L
E
T
F
S
A
-----------
I
-
P
A
N
-
E
G
G
K
K
I
A
V
L
A
D
M
K
E
L
G
D
Q
S
V
--
Q
L
H
--
N
Q
M
I
L
S
L
--
S
P
D
V
L
---
D
-----
I
V
I
F
Y
G
E
D
-----------
I
------
A
Q
------
L
A
Q
L
A
--
S
--
Q
-
M
--
F
P
I
G
H
V
Y
Y
F
K
K
T
E
D
Q
D
Q
F
E
D
L
V
K
Q
V
K
--
E
S
LGA
H
D
Q
----
I
L
L
K
G
S
N
S
M
-
N
L
A
-
K
L
V
E
S
L
E
N
--
1
PsiBlast_PDB
95.63
35%
-106
- C1 -
4CVK
5
?
A:
[28-447]
--------------------------
V
S
T
D
S
R
A
I
G
P
G
E
L
F
I
A
L
S
G
P
R
F
D
G
H
D
Y
L
A
E
V
A
A
K
G
A
V
A
A
L
V
E
R
E
V
A
----
A
P
------
L
P
Q
L
L
-
V
-
R
--
D
T
R
A
A
L
G
---------
R
L
G
A
L
N
R
R
K
F
--
T
G
P
L
------
A
A
M
T
G
S
S
G
K
T
T
V
K
E
M
L
A
S
I
L
R
T
Q
-
A
G
---------
D
--
A
E
SVL
A
T
R
G
-----
N
L
N
N
--
D
L
---
G
V
P
--
L
T
-----------------------------
L
L
Q
L
--
A
P
Q
H
R
-----
S
A
V
I
E
L
G
A
S
R
I
G
E
I
A
Y
T
V
E
L
T
R
P
H
V
A
I
I
T
N
A
-------
F
G
-
G
P
E
K
-
I
V
E
A
K
-
G
E
I
L
E
G
-
L
A
A
D
G
T
A
V
-------
L
N
L
D
D
-
K
A
-
F
D
T
W
K
A
R
A
-
S
G
R
P
L
-------
L
T
F
S
L
-
D
------------
R
-
P
Q
A
-
D
F
R
A
A
D
L
Q
R
D
A
R
G
C
M
G
F
R
L
Q
-
G
V
A
G
E
A
Q
-
V
Q
L
N
L
L
G
R
H
N
V
A
N
A
L
A
A
A
A
A
A
H
A
--
L
G
V
P
L
D
G
I
V
A
G
L
Q
A
L
Q
P
V
K
G
R
----
A
V
----
A
-
Q
L
---
T
A
S
--
G
L
R
V
-
I
D
D
S
Y
N
A
N
P
A
----
S
M
L
A
A
I
D
I
L
-
S
-----------
G
-
F
S
G
----
R
T
V
L
V
L
G
D
M
G
-----
A
E
--
Q
A
H
--
R
E
-
V
G
A
Y
--
A
A
G
K
V
---
S
-----
A
L
Y
A
V
G
P
L
-----------
M
--------------
A
H
A
V
Q
--
A
--
F
-
G
--
A
T
G
R
H
F
------
A
D
Q
A
S
L
I
G
A
L
A
T
-
E
--
D
P
---
T
T
T
----
I
L
I
K
G
S
R
S
A
-
A
M
D
-
K
V
V
A
A
L
C
---
9
PsiBlast_PDB
95.56
31%
-100
- C1 -
4ZIY
5
?
A:
[47-467]
-------------------------
R
I
L
T
D
S
R
H
A
E
S
G
D
A
F
L
A
L
K
G
E
R
F
D
A
H
N
F
V
A
Q
V
V
A
N
G
C
Q
V
A
I
V
E
R
P
-
I
D
---
A
E
------
I
A
Q
L
V
-
V
-
A
--
D
T
R
L
A
L
G
---------
Q
L
G
A
Y
R
-
R
E
Q
N
A
Q
L
K
V
------
I
A
L
T
G
S
S
G
K
T
T
T
K
E
M
L
G
S
I
L
-
S
R
-
L
A
---------
P
--
T
L
---
I
T
R
G
-----
N
L
N
N
--
D
L
---
G
V
P
--
M
M
-----------------------------
L
L
E
L
--
R
K
E
H
Q
-----
Y
A
V
M
E
L
G
A
N
H
Q
G
E
I
D
Y
T
S
K
I
V
Q
P
H
V
A
G
I
L
N
I
G
T
A
H
---
F
G
-
G
R
D
G
-
I
C
R
A
K
-
S
E
I
Y
R
H
-
I
L
P
Q
G
V
A
I
-------
V
P
Q
Q
D
-
D
F
-
T
A
E
I
R
E
A
A
K
S
-
H
Q
I
-------
M
S
F
G
A
-
G
------------
G
-
D
V
F
-
A
T
E
I
E
L
L
P
Q
S
A
N
F
Q
L
H
T
P
Q
G
-
S
-
S
F
V
----
R
L
P
F
A
G
E
H
N
V
Q
N
A
T
A
A
V
A
F
A
L
A
--
L
G
V
S
L
E
D
I
V
K
G
L
E
Q
A
Q
G
A
K
G
R
----------
L
-
N
F
---
I
Q
K
--
T
P
H
L
F
I
D
D
T
Y
N
A
N
P
T
----
S
M
R
A
A
A
Q
V
L
-------------
L
-
Q
Q
N
-
G
--
I
K
V
M
V
M
G
D
I
G
E
L
---
S
W
--
Q
E
H
--
H
D
L
G
R
D
L
--
A
E
L
P
L
---
D
-----
H
I
V
A
V
G
Q
F
-----------
A
S
A
A
L
EG-----------------------
T
K
L
K
A
F
------
Q
T
Q
A
E
A
L
P
F
L
I
N
L
I
--
Q
T
---
H
--Q
S
M
S
F
L
F
K
G
S
R
F
T
-
H
M
E
-
T
L
M
A
D
L
M
E
K
-
3
PsiBlast_PDB
95.55
33%
-111
- C1 -
3ZM5
1
?
A:
[32-452]
-----------------------------
D
S
R
L
I
G
T
G
D
L
F
V
P
L
K
G
A
R
-
D
G
H
D
F
I
E
T
A
F
E
N
G
A
A
V
-
T
L
S
E
K
-
E
V
---
S
N
------
H
P
Y
I
L
-
V
-
D
--
D
V
L
T
A
F
Q
---------
S
L
A
S
Y
Y
L
E
K
T
T
V
D
--
V
------
F
A
V
T
G
S
N
G
K
T
T
T
K
D
M
L
A
H
L
L
-
S
T
-
R
Y
---------
K
--
T
Y
---
K
T
Q
G
-----
N
Y
N
N
--
E
I
---
G
L
P
--
Y
T
-----------------------------
V
L
H
M
--
P
E
G
T
E
-----
K
L
V
L
E
M
G
Q
D
H
L
G
D
I
H
L
L
S
E
L
A
R
P
K
T
A
I
V
T
L
V
G
E
A
H
L
A
F
F
K
-
D
R
S
E
-
I
A
K
G
K
-
M
Q
I
A
D
G
-
M
A
S
G
S
L
L
L
-------
A
P
A
D
P
-
I
V
-
E
D
Y
L
--
P
I
-
D
-
K
K
V
-------
V
R
F
G
Q
----------------
G
A
E
-
L
E
I
T
D
L
V
E
R
K
D
S
L
T
F
K
A
N
F
L
-
E
-
Q
A
L
----
D
L
P
V
T
G
K
Y
N
A
T
N
A
M
I
A
S
Y
V
A
L
Q
--
E
G
V
S
E
E
Q
I
R
L
A
F
Q
H
L
E
L
T
R
N
R
----
T
E
W
K
K
-
A
-
A
----
N
G
A
--
D
I
---
L
S
D
V
Y
N
A
N
P
T
----
A
M
K
L
I
L
E
T
F
S
A
-----------
I
-
P
A
N
-
E
G
G
K
K
I
A
V
L
A
D
M
K
E
L
G
D
Q
S
V
--
Q
L
H
--
N
Q
M
I
L
S
L
--
S
P
D
V
L
---
D
-----
I
V
I
F
Y
G
E
D
-----------
I
------
A
Q
------
L
A
Q
L
A
--
S
--
Q
-
M
--
F
P
I
G
H
V
Y
Y
F
K
K
T
E
D
Q
D
Q
F
E
D
L
V
K
Q
V
K
--
E
S
LGA
H
D
Q
----
I
L
L
K
G
S
N
S
M
-
N
L
A
-
K
L
V
E
S
L
E
N
--
2
PsiBlast_PDB
94.87
35%
-102
- C1 -
4CVM
7
?
A:
[28-447]
--------------------------
V
S
T
D
S
R
A
I
G
P
G
E
L
F
I
A
L
S
G
P
R
F
D
G
H
D
Y
L
A
E
V
A
A
K
G
A
V
A
A
L
V
E
R
E
V
A
D
---
A
P
------
L
P
Q
L
L
-
V
-
R
--
D
T
R
A
A
L
G
---------
R
L
G
A
L
N
R
R
K
F
--
T
G
P
L
------
A
A
M
T
G
S
S
G
K
T
T
V
K
E
M
L
A
S
I
L
R
T
Q
-
A
G
---------
D
--
A
E
SVL
A
T
R
G
-----
N
L
N
N
--
D
L
---
G
V
P
--
L
T
-----------------------------
L
L
Q
L
--
A
P
Q
H
R
-----
S
A
V
I
E
L
G
A
S
R
I
G
E
I
A
Y
T
V
E
L
T
R
P
H
V
A
I
I
T
N
A
G
T
A
H
V
---
G
-
G
P
E
K
-
I
V
E
A
K
-
G
E
I
L
E
G
-
L
A
A
D
G
T
A
V
-------
L
N
L
D
D
-
K
A
-
F
D
T
W
K
A
R
A
-
S
G
R
P
L
-------
L
T
F
S
L
-
D
------------
R
-
P
Q
A
-
D
F
R
A
A
D
L
Q
R
D
A
R
G
C
M
G
F
R
L
Q
-
G
V
A
G
E
A
Q
-
V
Q
L
N
L
L
G
R
H
N
V
A
N
A
L
A
A
A
A
A
A
H
A
--
L
G
V
P
L
D
G
I
V
A
G
L
Q
A
L
Q
P
V
K
G
R
----
A
V
----
A
-
Q
L
---
T
A
S
--
G
L
R
V
-
I
D
D
S
Y
N
A
N
P
A
----
S
M
L
A
A
I
D
I
L
-
S
-----------
G
-
F
S
G
----
R
T
V
L
V
L
G
D
M
G
-----
A
E
--
Q
A
H
--
R
E
-
V
G
A
Y
--
A
A
G
K
V
---
S
-----
A
L
Y
A
V
G
P
L
-----------
M
--------------
A
H
A
V
Q
--
A
--
F
-
G
--
A
T
G
R
H
F
------
A
D
Q
A
S
L
I
G
A
L
A
T
-
E
--
D
P
---
T
T
T
----
I
L
I
K
G
S
R
S
A
-
A
M
D
-
K
V
V
A
A
L
C
---
8
PsiBlast_PDB
94.69
31%
-99
- C1 -
4QDI
5
?
A:
[45-465]
-------------------------
R
I
L
T
D
S
R
H
A
E
S
G
D
A
F
L
A
L
K
G
E
R
F
D
A
H
N
F
V
A
Q
V
V
A
N
G
C
Q
V
A
I
V
E
R
P
-
I
D
---
A
E
------
I
A
Q
L
V
-
V
-
A
--
D
T
R
L
A
L
G
---------
Q
L
G
A
Y
R
-
R
E
Q
N
A
Q
L
K
V
------
I
A
L
T
G
S
S
G
K
T
T
T
K
E
M
L
G
S
I
L
-
S
R
-
L
A
---------
P
--
T
L
---
I
T
R
G
-----
N
L
N
N
--
D
L
---
G
V
P
--
M
M
-----------------------------
L
L
E
L
--
R
K
E
H
Q
-----
Y
A
V
M
E
L
G
A
N
H
Q
G
E
I
D
Y
T
S
K
I
V
Q
P
H
V
A
G
I
L
N
I
G
T
A
H
L
G
E
F
G
-
G
R
D
G
-
I
C
R
A
K
-
S
E
I
Y
R
H
-
I
L
P
Q
G
V
A
I
-------
V
P
Q
Q
D
-
D
F
-
T
A
E
I
R
E
A
A
K
S
-
H
Q
I
-------
M
S
F
G
E
-
G
------------
G
-
D
V
F
-
A
T
E
I
E
L
L
P
Q
S
A
N
F
Q
L
H
T
P
Q
G
-
S
-
S
F
V
----
R
L
P
F
A
G
E
H
N
V
Q
N
A
T
A
A
V
A
F
A
L
A
--
L
G
V
S
L
E
D
I
V
K
G
L
E
Q
A
Q
G
A
K
G
R
----------
L
-
N
F
---
I
Q
K
--
A
P
H
L
F
I
D
D
T
Y
N
A
N
P
T
----
S
M
R
A
A
A
Q
V
L
-------------
L
-
Q
Q
N
-
G
--
I
K
V
M
V
M
G
D
I
G
E
L
G
D
S
S
W
--
Q
E
H
--
H
D
L
G
R
D
L
--
A
E
L
P
L
---
D
-----
H
I
V
A
V
G
Q
F
-----------
A
S
A
A
L
E
G
A
G
------
L
H
----------
S
--
T
K
L
K
A
F
------
Q
T
Q
A
E
A
L
P
F
L
I
N
L
I
--
Q
T
---
H
Q
P
Q
S
M
S
F
L
F
K
G
S
R
F
T
-
H
M
E
-
T
L
M
A
D
L
M
E
K
-
6
PsiBlast_PDB
94.23
32%
-108
- C1 -
2AM1
2
?
A:
[32-452]
-----------------------------
D
S
R
L
I
G
T
G
D
L
F
V
P
L
K
G
A
R
-
D
G
H
D
F
I
E
T
A
F
E
N
G
A
A
V
-
T
L
S
E
K
-
E
V
---
S
N
------
H
P
Y
I
L
-
V
-
D
--
D
V
L
T
A
F
Q
---------
S
L
A
S
Y
Y
L
E
K
T
T
V
D
--
V
------
F
A
V
T
G
S
N
G
K
T
T
T
K
D
M
L
A
H
L
L
-
S
T
-
R
Y
---------
K
--
T
Y
---
K
T
Q
G
-----
N
Y
N
N
--
E
I
---
G
L
P
--
Y
T
-----------------------------
V
L
H
M
--
P
E
G
T
E
-----
K
L
V
L
E
M
G
Q
D
H
L
G
D
I
H
L
L
S
E
L
A
R
P
K
T
A
I
V
T
L
V
G
E
A
H
L
A
F
F
K
-
D
R
S
E
-
I
A
K
G
K
-
M
Q
I
A
D
G
-
M
A
S
G
S
L
L
L
-------
A
P
A
D
P
-
I
V
-
E
D
Y
L
--
P
I
-
D
-
K
K
V
-------
V
R
F
G
Q
----------------
G
A
E
-
L
E
I
T
D
L
V
E
R
K
D
S
L
T
F
K
A
N
F
L
-
E
-
Q
A
L
----
D
L
P
V
T
G
K
Y
N
A
T
N
A
M
I
A
S
Y
V
A
L
Q
--
E
G
V
S
E
E
Q
I
R
L
A
F
Q
H
L
E
L
T
R
N
R
----
T
E
W
K
K
-
A
-
A
----
N
G
A
--
D
I
---
L
S
D
V
Y
N
A
N
P
T
----
A
M
K
L
I
L
E
T
F
S
A
-----------
I
-
P
A
N
-
E
G
G
K
K
I
A
V
L
A
D
M
K
E
L
G
D
Q
S
V
--
Q
L
H
--
N
Q
M
I
L
S
L
--
S
P
D
V
L
---
D
-----
I
V
I
F
Y
G
E
D
-----------
I
------
A
Q
------
L
A
Q
L
A
--
S
--
Q
-
M
--
F
P
I
G
H
V
Y
Y
F
K
K
T
E
D
Q
D
Q
F
E
D
L
V
K
Q
V
K
--
E
S
LGA
H
D
Q
----
I
L
L
K
G
S
N
S
M
-
N
L
A
-
K
L
V
E
S
L
E
N
--
7
PsiBlast_PDB
94.09
32%
-114
- C1 -
2AM2
1
?
A:
[32-452]
-----------------------------
D
S
R
L
I
G
T
G
D
L
F
V
P
L
K
G
A
R
-
D
G
H
D
F
I
E
T
A
F
E
N
G
A
A
V
-
T
L
S
E
K
-
E
V
---
S
N
------
H
P
Y
I
L
-
V
-
D
--
D
V
L
T
A
F
Q
---------
S
L
A
S
Y
Y
L
E
K
T
T
V
D
--
V
------
F
A
V
T
G
S
N
G
K
T
T
T
K
D
M
L
A
H
L
L
-
S
T
-
R
Y
---------
K
--
T
Y
---
K
T
Q
G
-----
N
Y
N
N
--
E
I
---
G
L
P
--
Y
T
-----------------------------
V
L
H
M
--
P
E
G
T
E
-----
K
L
V
L
E
M
G
Q
D
H
L
G
D
I
H
L
L
S
E
L
A
R
P
K
T
A
I
V
T
L
V
G
E
A
H
L
A
F
F
K
-
D
R
S
E
-
I
A
K
G
K
-
M
Q
I
A
D
G
-
M
A
S
G
S
L
L
L
-------
A
P
A
D
P
-
I
V
-
E
D
Y
L
--
P
I
-
D
-
K
K
V
-------
V
R
F
G
Q
----------------
G
A
E
-
L
E
I
T
D
L
V
E
R
K
D
S
L
T
F
K
A
N
F
L
-
E
-
Q
A
L
----
D
L
P
V
T
G
K
Y
N
A
T
N
A
M
I
A
S
Y
V
A
L
Q
--
E
G
V
S
E
E
Q
I
R
L
A
F
Q
H
L
E
L
T
R
N
R
----
T
E
W
K
K
-
A
-
A
----
N
G
A
--
D
I
---
L
S
D
V
Y
N
A
N
P
T
----
A
M
K
L
I
L
E
T
F
S
A
-----------
I
-
P
A
N
-
E
G
G
K
K
I
A
V
L
A
D
M
K
E
L
G
D
Q
S
V
--
Q
L
H
--
N
Q
M
I
L
S
L
--
S
P
D
V
L
---
D
-----
I
V
I
F
Y
G
E
D
-----------
I
------
A
Q
------
L
A
Q
L
A
--
S
--
Q
-
M
--
F
P
I
G
H
V
Y
Y
F
K
K
T
E
D
Q
D
Q
F
E
D
L
V
K
Q
V
K
--
E
S
LGA
H
D
Q
----
I
L
L
K
G
S
N
S
M
-
N
L
A
-
K
L
V
E
S
L
E
N
--
10
PsiBlast_PDB
88.61
28%
-101
- C1 -
3ZL8
2
?
A:
[13-419]
------------------------------
S
K
E
V
R
E
G
D
V
F
V
A
V
K
G
K
R
F
D
G
H
D
F
I
D
E
A
L
R
N
G
A
Y
A
I
I
A
E
R
K
-
T
V
---
N
S
------
D
R
I
F
L
-
V
-
E
--
S
S
V
D
T
L
A
---------
K
L
A
R
E
K
L
G
N
F
--
S
G
T
V
------
V
G
V
T
G
S
S
G
K
T
T
T
K
E
I
L
Y
N
L
L
-
K
N
-
K
R
---------
S
--
V
F
---
K
T
P
G
-----
N
M
N
T
--
E
Y
---
G
L
P
--
L
S
-----------------------------
I
L
N
D
--
Y
K
G
E
E
-----
I
L
V
L
E
M
A
A
S
R
P
G
D
I
A
H
L
C
K
I
A
P
P
D
V
A
V
L
L
N
V
G
S
A
H
L
E
F
F
G
-
T
R
E
R
-
I
M
E
T
K
-
M
E
I
I
K
H
-
S
K
E
N
A
I
A
V
T
L
FDD
P
D
L
R
K
E
V
-
P
R
-
Y
----------
R
N
T
-------
L
F
F
G
K
-
E
GGD
S
V
L
K
D
W
W
Y
Y
E
-
G
S
T
-
I
A
E
F
E
A
F
D
S
L
F
T
V
K
L
S
G
Y
W
N
-
G
-
G
Q
L
L
N
--------------
I
A
A
S
L
C
V
M
R
T
--
L
G
E
T
V
D
I
F
D
L
A
--
S
L
K
T
V
P
G
R
----
F
N
V
R
E
-
K
--------
K
--
G
V
L
I
-
V
D
D
T
Y
N
A
S
P
E
----
A
F
Q
T
S
I
E
A
L
-
L
-----------
R
-
F
P
G
----
K
K
F
A
V
V
G
A
M
K
E
L
G
E
R
S
K
--
E
F
H
--
E
E
L
G
E
R
L
----
N
V
L
---
D
-----
G
V
Y
V
F
-----------------------------
L
S
E
P
E
--
A
--
E
-
W
--
I
K
S
K
K
I
ILKS--
D
D
P
E
K
I
A
K
D
L
A
T
R
V
--
K
K
---
G
D
V
----
V
L
F
K
A
S
R
A
V
-
R
I
E
-
R
V
L
E
M
F
E
K
E
L
12
PsiBlast_PDB
77.68
24%
-89
- C1 -
1GQY
2
MURC_HAEIN
A:
[72-462]
-------------------------------------------------------
E
E
H
I
E
G
A
S
V
V
V
V
S
S
A
-
I
K
---
D
D
------
N
P
E
L
V
-
T
-
S
--
K
Q
K
R
I
P
V
---------
I
Q
R
A
Q
M
L
A
E
I
M
R
F
R
H
G
------
I
A
V
A
G
T
H
G
K
T
T
T
T
A
M
I
S
M
I
Y
-
T
Q
-
A
K
---------
L
D
P
T
F
---
V
N
G
G
LVKSA
G
K
N
A
--
H
L
---
G
A
-------------------------------------------
S
R
-----
Y
L
I
A
E
A
D
E
S
D
A
S
F
L
H
-----
L
Q
P
M
V
S
V
V
T
N
M
E
P
D
--------
D
F
E
-
K
M
K
A
T
Y
V
K
F
L
H
N
-
L
P
F
Y
G
L
A
V
-------
M
C
A
D
D
-
P
V
-
L
M
E
L
V
P
K
V
-
G
-
R
Q
V
-------
I
T
Y
G
F
-
S
------------
E
-
Q
A
D
-
Y
R
I
E
D
Y
E
Q
T
G
F
Q
G
H
Y
T
V
I
C
P
-
N
-
N
E
R
I
N
-
V
L
L
N
V
P
G
K
H
N
A
L
N
A
T
A
A
L
A
V
A
K
E
--
E
G
I
A
N
E
A
I
L
E
A
L
A
D
F
Q
-
G
A
G
R
----
R
F
D
Q
L
-
G
-
E
F
I
R
P
N
G
K
---
V
R
L
-
V
D
D
-
Y
G
H
H
P
T
E
V
G
V
T
I
K
A
A
R
E
G
W
-
G
D
K
R
I
V
M
I
F
Q
P
H
R
-
Y
S
R
-
T
--
R
D
--
L
F
D
D
F
V
Q
V
------------
L
S
Q
V
D
A
L
--
I
M
L
D
V
YAA
G
-----
E
A
P
I
V
G
A
D
-----------
S
------
K
S
------
L
C
R
S
I
--
R
N
L
G
-
K
--
V
D
P
I
L
V
------
S
D
T
S
Q
L
G
D
V
L
D
Q
I
I
--
Q
D
---
G
D
L
----
I
L
A
Q
G
A
G
S
V
-
S
K
I
-
S
R
G
L
A
E
S
W
K
N
29
HHSearch
76.97
22%
-89
* C1 *
1P3D
4
MURC_HAEIN
A:
[76-473]
-----------------------------------------------------------
E
G
A
S
V
V
V
V
S
S
A
-
I
K
---
D
D
------
N
P
E
L
V
T
S
K
Q
--
K
R
I
P
V
I
Q
R
A
Q
------
M
L
A
E
I
M
R
-----
F
R
H
G
------
I
A
V
A
G
T
H
G
K
T
T
T
T
A
M
I
S
M
I
Y
-
T
Q
A
K
L
---------
D
--
P
T
---
F
V
N
G
-----
G
------
L
---
V
K
S
--
A
G
-----------------------------
K
N
A
H
--
L
G
A
S
R
-----
Y
L
I
A
E
A
D
E
S
D
A
-----
S
F
L
H
L
Q
P
M
V
S
V
V
T
N
M
E
P
D
H
M
D
T
Y
E
G
D
F
E
K
-
M
K
A
T
Y
-
V
K
F
L
H
N
L
P
-
F
Y
G
L
A
V
-------
M
C
A
D
D
-
P
V
-
L
M
E
L
V
P
K
V
---
G
R
Q
V
------
I
T
Y
G
F
-
S
------------
E
-
Q
A
D
-
Y
R
I
E
D
Y
E
Q
T
G
F
Q
G
H
Y
T
V
I
C
P
N
N
-
E
-
R
I
N
-
V
L
L
N
V
P
G
K
H
N
A
L
N
A
T
A
A
L
A
V
A
K
E
--
E
G
I
A
N
E
A
I
L
E
A
L
A
D
F
Q
G
A
G
R
R
----
F
D
Q
L
G
-
E
F
I
R
---
P
N
G
--
K
V
R
L
-
V
D
D
-
Y
G
H
H
P
T
----
E
V
G
V
T
I
K
A
A
-
R
-----------
E
-
G
W
G
D
K
--
R
I
V
M
I
F
Q
P
H
R
--
Y
S
R
T
R
--
D
L
F
--
D
D
F
V
Q
V
L
--
S
Q
--
V
---
D
-----
A
L
I
M
L
D
V
Y
AAGEAPIVGAD
S
------
K
S
------
L
C
R
S
I
--
R
--
N
-
L
GK
V
D
P
I
L
V
------
S
D
T
S
Q
L
G
D
V
L
D
Q
I
I
--
Q
D
---
G
D
L
----
I
L
A
Q
G
A
G
S
V
S
K
I
S
R
G
L
A
E
S
W
----
13
PsiBlast_PDB
74.88
24%
-99
- C1 -
4HV4
2
MURC_YERPE
A:
[125-468]
-------------------------------------------------------------------------------------------------------------------------------------
I
A
V
A
G
T
H
G
K
T
T
T
T
A
M
L
S
S
I
Y
-
A
E
-
A
G
---------
L
D
P
T
F
---
V
N
-
G
-----
G
L
V
K
--
A
A
---
G
T
H
--
A
R
-----------------------------
L
------
G
S
S
R
-----
Y
L
I
A
E
A
D
E
S
D
A
S
F
L
H
-----
L
Q
P
M
V
A
I
V
T
N
I
E
A
D
H
M
D
T
Y
Q
-
G
D
F
E
N
L
K
Q
T
F
-
I
N
F
L
H
N
-
L
P
F
Y
G
R
A
V
-------
M
C
I
D
D
-
P
V
-
V
R
E
L
L
P
R
V
-
G
-
R
H
I
-------
T
T
Y
G
F
-
S
------------
D
-
D
A
D
-
V
Q
I
A
S
Y
R
Q
E
G
P
Q
G
H
F
T
L
R
R
Q
-
D
-
K
P
L
I
E
-
V
T
L
N
A
P
G
R
H
N
A
L
N
A
A
A
A
V
A
V
A
T
E
--
E
G
I
E
D
E
D
I
L
R
A
L
V
G
F
Q
G
T
G
R
R
FDFL
G
N
F
P
L
-
A
-
P
V
---
N
G
K
E
G
S
A
M
L
-
V
D
D
-
Y
G
H
H
P
T
----
E
V
D
A
T
I
K
A
A
-
R
-----------
A
G
W
P
D
-
K
--
R
I
V
M
L
F
Q
P
H
R
Y
T
R
T
R
D
L
Y
D
D
F
A
N
V
L
S
Q
V
D
V
L
--
L
M
L
D
-----------
V
Y
A
A
G
E
P
-----------
P
------
I
P
GAD
S
R
A
L
C
R
T
I
R
N
R
--
G
-
K
--
L
D
P
I
L
V
------
P
D
S
E
S
A
P
E
M
L
A
Q
I
L
--
N
G
---
E
D
L
----
I
L
V
Q
G
A
G
N
I
-
G
K
I
-
A
R
K
L
A
E
H
K
L
Q
14
PsiBlast_PDB
73.14
24%
-93
- C1 -
2F00
1
MURC_ECOLI
A:
[97-465]
---------------------------------------------------------------------------------------------------
A
A
H
---------
E
A
R
I
P
V
I
R
R
A
E
M
L
A
E
L
M
RFRH
G
I
A
I
A
G
T
H
G
K
T
T
T
T
A
M
V
S
S
I
Y
-
A
E
-
A
G
---------
L
D
P
T
F
---
V
N
-
G
-----
G
L
V
K
--
A
A
---
G
V
H
--
A
R
-----------------------------
L
------
G
H
G
R
-----
Y
L
I
A
E
A
D
E
S
D
A
S
F
L
H
-----
L
Q
P
M
V
A
I
V
T
N
I
E
A
D
H
M
D
T
Y
Q
-
G
D
F
E
N
L
K
Q
T
F
-
I
N
F
L
H
N
-
L
P
F
Y
G
R
A
V
-------
M
C
V
D
D
-
P
V
-
I
R
E
L
L
P
R
V
-
G
-
R
Q
T
-------
T
T
Y
G
F
-
S
------------
E
-
D
A
D
-
V
R
V
E
D
Y
Q
Q
I
G
P
Q
G
H
F
T
L
L
R
Q
-
D
-
K
E
P
M
R
-
V
T
L
N
A
P
G
R
H
N
A
L
N
A
A
A
A
V
A
V
A
T
E
--
E
G
I
D
D
E
A
I
L
R
A
L
E
S
F
Q
G
T
G
R
R
FDFL
G
E
F
P
L
-
E
-
P
V
---
N
G
K
S
G
T
A
M
L
-
V
D
D
-
Y
G
H
H
P
T
----
E
V
D
A
T
I
K
A
A
-
R
-----------
A
G
W
P
D
-
K
--
N
L
V
M
L
------
F
Q
P
H
R
F
--
T
R
T
--
R
D
L
Y
D
D
F
A
N
V
L
T
Q
V
---
D
T
L
L
M
L
E
V
Y
P
A
G
E
A
-----------
P
------
I
P
GAD
S
R
S
L
C
R
T
------------
D
P
I
L
V
------
P
D
P
A
R
V
A
E
M
L
A
P
V
L
--
T
G
---
N
D
L
----
I
L
V
Q
G
A
G
N
I
-
G
K
I
-
A
R
S
L
A
E
I
K
L
K
24
HHSearch
72.25
24%
-75
- C1 -
3LK7
3
MURD_STRA5
A:
[19-427]
-----------------------
R
S
G
E
A
A
A
R
L
L
A
K
L
G
A
I
V
T
V
N
D
G
K
P
F
D
E
N
P
T
A
Q
S
L
L
E
E
G
I
K
V
V
C
G
S
H
P
-
L
E
L
L
D
E
D
FC
Y
M
I
K
N
P
G
I
P
-
Y
-
N
N
P
M
V
K
K
A
L
E
K
QI
P
V
L
T
E
V
E
L
A
Y
L
-----
V
S
E
S
Q
L
------
I
G
I
T
G
S
N
G
K
T
T
T
T
T
M
I
A
E
V
L
-
N
A
G
G
----------
Q
---------
R
G
-----
L
L
A
G
--
N
I
---
G
F
P
--
A
S
E
----------------------------
V
V
Q
A
--
A
N
D
K
D
-----
T
L
V
M
E
L
S
S
F
Q
L
M
---
G
-
V
K
E
F
R
P
H
I
A
V
I
T
N
L
M
P
T
H
L
D
Y
H
G
-
S
F
E
D
-
Y
V
A
A
K
-
W
N
I
Q
N
Q
M
S
-
S
S
D
F
L
V
-------
L
N
F
N
Q
-
G
I
-
S
K
E
L
A
K
T
T
---
K
A
T
I
------
V
P
F
S
T
-
T
------------
E
-
K
V
D
G
A
Y
V
Q
D
-------
K
Q
L
F
--
Y
K
-
G
-
E
N
I
M
S
V
D
D
I
G
V
P
G
S
H
N
V
E
N
A
L
A
T
I
A
V
A
K
L
--
A
G
I
S
N
Q
V
I
R
E
T
L
S
N
F
G
G
V
K
H
R
----
L
Q
S
L
G
-
K
-------
V
H
--
G
I
S
F
-
Y
N
D
S
K
S
T
N
I
L
----
A
T
Q
K
A
L
S
G
F
-
D
---------------
N
-
T
--
K
V
I
L
I
A
G
G
L
-
D
R
G
N
E
-----
F
---
D
E
L
I
P
D
I
--
T
G
--
L
---
K
-----
H
M
V
V
L
G
E
S
-----------
A
------
S
R
------
V
K
R
A
A
--
Q
--
K
A
G
--
V
T
Y
S
D
A
------
L
D
V
R
D
A
V
H
K
A
Y
E
V
A
--
Q
Q
---
G
D
V
----
I
L
L
S
P
A
N
A
S
-
W
D
M
-
Y
K
N
F
E
V
R
G
D
E
5
PsiBlast_PDB
71.84
32%
-15
- C1 -
1GG4
-
MURF_ECOLI
A:
[27-446]
--------------------------
V
T
T
D
T
R
K
L
T
P
G
C
L
F
V
A
L
K
G
E
R
F
D
A
H
D
F
A
D
Q
A
K
A
G
G
A
G
A
L
L
V
S
R
P
-
L
D
---
I
D
------
L
P
Q
L
I
-
V
-
K
--
D
T
R
L
A
F
G
---------
E
L
A
A
W
V
R
Q
Q
V
--
P
A
R
V
------
V
A
L
T
G
S
S
G
K
T
S
V
K
E
M
T
A
A
I
L
-
S
Q
-
C
G
---------
N
--
T
L
---
Y
T
A
G
-----
N
L
N
N
--
D
I
---
G
V
P
--
M
T
-----------------------------
L
L
R
L
--
T
P
E
Y
D
-----
Y
A
V
I
E
L
G
A
N
H
Q
G
E
I
A
W
T
V
S
L
T
R
P
E
A
A
L
V
N
N
L
A
---------
S
L
A
G
-
V
A
K
A
K
-
G
E
I
F
S
G
-
L
P
E
N
G
I
A
I
-------
M
N
A
D
N
-
N
D
-
W
L
N
W
Q
S
V
I
G
S
-
R
K
V
-------
W
R
F
S
P
N
A
------------
A
-
N
S
D
-
F
T
A
T
N
I
H
V
T
S
H
G
T
E
F
T
L
Q
T
P
-
T
-
G
S
V
-
D
-
V
L
L
P
L
P
G
R
H
N
I
A
N
A
L
A
A
A
A
L
S
M
S
--
V
G
A
T
L
D
A
I
K
A
G
L
A
N
L
K
A
V
P
G
R
----
L
F
P
I
Q
-
L
-
A
E
---
N
Q
L
-----
L
-
L
D
D
S
Y
N
A
N
V
G
----
S
M
T
A
A
V
Q
V
L
-
A
-----------
E
-
M
P
G
-
Y
--
R
-
V
L
V
V
G
D
M
A
E
L
G
A
E
S
E
--
A
C
H
--
V
Q
V
G
E
A
A
--
K
A
A
G
I
---
D
-----
R
V
L
S
V
G
K
--------------------
Q
------
S
H
A
I
S
--
T
--
A
-
S
--
G
V
G
E
H
F
------
A
D
K
T
A
L
I
T
R
L
K
L
L
I
--
A
E
---
Q
Q
V
I
T
--
I
L
V
K
G
S
R
S
A
-
A
M
E
-
E
V
V
R
A
L
Q
---
15
PsiBlast_PDB
70.82
24%
-106
- C1 -
4BUB
2
MURE_THEMA
A:
[28-372]
--------------------------
V
S
N
H
S
S
K
V
K
K
G
D
L
F
I
C
R
R
-------
E
I
I
P
E
V
M
E
K
G
A
V
A
V
V
V
E
R
E
-
I
D
---
L
D
------
F
P
Y
I
Q
-
V
-
F
--
D
S
R
Y
F
E
A
---------
K
V
A
S
L
F
F
E
D
P
W
K
D
V
L
T
------
F
G
V
T
G
T
N
G
K
T
T
T
T
M
M
I
Y
H
M
L
-
T
S
-
L
G
E
R
G
S
V
L
T
TA
V
--
K
R
---
I
L
G
N
-----
S
Y
Y
D
--
D
I
---
T
T
P
D
A
I
T
-----------------------------
I
L
S
A
--
M
K
E
N
R
E
G
GGK
F
F
A
L
E
V
S
S
H
A
L
--
V
Q
Q
R
V
E
G
V
R
F
D
V
G
I
F
T
N
I
S
R
D
H
L
D
F
H
G
-
T
F
E
N
-
Y
L
K
A
K
-
L
H
L
F
D
L
-
L
K
D
D
G
V
A
V
-------
L
N
E
S
--------
L
A
D
A
F
-
N
-
R
K
S
R
K
-----
I
T
F
G
T
-
S
------------
K
-
N
A
D
-
Y
R
L
G
N
I
E
V
S
W
E
G
T
Q
F
V
L
E
T
P
-
D
-
G
L
L
K
V
-
F
T
R
A
I
-
G
D
F
N
A
Y
N
A
A
A
A
I
A
A
L
H
Q
--
L
G
Y
D
P
K
D
L
A
S
S
L
E
T
F
T
G
V
E
G
R
----
F
E
V
V
R
G
A
-
K
K
---
I
G
L
--
N
V
-
V
-
V
D
--
F
A
H
S
P
D
----
A
L
E
K
L
L
K
N
V
-
R
-----------
K
-
I
S
Q
-
G
--
R
V
I
V
V
F
G
A
G
G
N
S
D
R
G
K
R
--
P
M
M
--
S
E
V
A
S
K
L
--
A
D
V
V
I
---
L
-----
T
T
D
D
P
R
G
E
-----------
D
------
P
E
------
Q
I
M
E
D
--
L
--
I
-
K
--
G
I
D
K
R
K
------
P
Y
L
V
L
F
D
R
R
E
A
I
E
T
--
A
L
---
T
I
A
----
N
R
G
D
S
V
V
I
A
-
G
R
G
-
H
E
R
Y
Q
I
I
D
E
E
17
PsiBlast_PDB
69.66
24%
-90
- C1 -
1P3D
4
MURC_HAEIN
A:
[167-462]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
-----
Y
L
I
A
E
A
D
E
S
D
A
S
F
L
H
-----
L
Q
P
M
V
S
V
V
T
N
M
E
P
D
H
M
D
T
Y
E
-
G
D
F
E
-
K
M
K
A
T
Y
V
K
F
L
H
N
-
L
P
F
Y
G
L
A
V
-------
M
C
A
D
D
-
P
V
-
L
M
E
L
V
P
K
V
-
G
-
R
Q
V
-------
I
T
Y
G
F
-
S
------------
E
-
Q
A
D
-
Y
R
I
E
D
Y
E
Q
T
G
F
Q
G
H
Y
T
V
I
C
P
-
N
-
N
E
R
I
N
-
V
L
L
N
V
P
G
K
H
N
A
L
N
A
T
A
A
L
A
V
A
K
E
--
E
G
I
A
N
E
A
I
L
E
A
L
A
D
F
Q
-
G
A
G
R
----
R
F
D
Q
L
-
G
-
E
F
I
R
P
N
G
K
---
V
R
L
-
V
D
D
-
Y
G
H
H
P
T
E
V
G
V
T
I
K
A
A
R
E
G
W
-
G
D
K
R
I
V
M
I
F
Q
P
H
R
-
Y
S
R
-
T
--
R
D
--
L
F
D
D
F
V
Q
V
------------
L
S
Q
V
D
A
L
--
I
M
L
D
V
YAA
G
-----
E
A
P
I
V
G
A
D
-----------
S
------
K
S
------
L
C
R
S
I
--
R
N
L
G
-
K
--
V
D
P
I
L
V
------
S
D
T
S
Q
L
G
D
V
L
D
Q
I
I
--
Q
D
---
G
D
L
----
I
L
A
Q
G
A
G
S
V
-
S
K
I
-
S
R
G
L
A
E
S
W
--
16
PsiBlast_PDB
69.26
24%
-91
- C1 -
1P31
2
MURC_HAEIN
A:
[167-462]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
-----
Y
L
I
A
E
A
D
E
S
D
A
S
F
L
H
-----
L
Q
P
M
V
S
V
V
T
N
M
E
P
D
H
M
D
T
Y
E
-
G
D
F
E
-
K
M
K
A
T
Y
V
K
F
L
H
N
-
L
P
F
Y
G
L
A
V
-------
M
C
A
D
D
-
P
V
-
L
M
E
L
V
P
K
V
-
G
-
R
Q
V
-------
I
T
Y
G
F
-
S
------------
E
-
Q
A
D
-
Y
R
I
E
D
Y
E
Q
T
G
F
Q
G
H
Y
T
V
I
C
P
-
N
-
N
E
R
I
N
-
V
L
L
N
V
P
G
K
H
N
A
L
N
A
T
A
A
L
A
V
A
K
E
--
E
G
I
A
N
E
A
I
L
E
A
L
A
D
F
Q
-
G
A
G
R
----
R
F
D
Q
L
-
G
-
E
F
I
R
P
N
G
K
---
V
R
L
-
V
D
D
-
Y
G
H
H
P
T
E
V
G
V
T
I
K
A
A
R
E
G
W
-
G
D
K
R
I
V
M
I
F
Q
P
H
R
-
Y
S
R
-
T
--
R
D
--
L
F
D
D
F
V
Q
V
------------
L
S
Q
V
D
A
L
--
I
M
L
D
V
YAA
G
-----
E
A
P
I
V
G
A
D
-----------
S
------
K
S
------
L
C
R
S
I
--
R
N
L
G
-
K
--
V
D
P
I
L
V
------
S
D
T
S
Q
L
G
D
V
L
D
Q
I
I
--
Q
D
---
G
D
L
----
I
L
A
Q
G
A
G
S
V
-
S
K
I
-
S
R
G
L
A
E
S
W
K
-
21
HHSearch
67.84
32%
1
- C1 -
1GG4
-
MURF_ECOLI
A:
[1-447]
M
I
S
V
T
L
S
Q
L
T
D
I
L
N
G
E
L
Q
G
A
D
I
T
L
D
A
V
T
T
D
T
R
K
L
T
P
G
C
L
F
V
A
L
K
G
E
R
F
D
A
H
D
F
A
D
Q
A
K
A
G
G
A
G
A
L
L
V
S
R
P
-
L
D
---
I
D
------
L
P
Q
L
I
-
V
-
K
--
D
T
R
L
A
F
G
---------
E
L
A
A
W
V
R
Q
--
Q
V
P
A
R
V
------
V
A
L
T
G
S
S
G
K
T
S
V
K
E
M
T
A
A
I
L
-
S
Q
C
G
----------
N
--
T
L
---
Y
T
A
G
-----
N
L
N
N
--
D
I
---
G
V
P
--
M
T
-----------------------------
L
L
R
L
--
T
P
E
Y
D
-----
Y
A
V
I
E
L
G
A
N
H
Q
G
E
I
A
W
T
V
S
L
T
R
P
E
A
A
L
V
N
N
L
A
---------
S
L
A
G
-
V
A
K
A
K
-
G
E
I
F
S
G
L
P
-
E
N
G
I
A
I
-------
M
N
A
D
N
-
N
D
-
W
L
N
W
Q
S
V
I
-
G
-
S
R
K
V
------
W
R
F
S
P
-
N
------------
A
A
N
S
D
-
F
T
A
T
N
I
H
V
T
S
H
G
T
E
F
T
L
Q
T
P
-
T
-
G
-
S
V
D
-
V
L
L
P
L
P
G
R
H
N
I
A
N
A
L
A
A
A
A
L
S
M
S
--
V
G
A
T
L
D
A
I
K
A
G
L
A
N
L
K
A
V
P
G
R
----
L
F
P
I
Q
-
L
-------
A
E
--
N
Q
L
L
-
L
D
D
S
Y
N
A
N
V
G
----
S
M
T
A
A
V
Q
V
L
-
A
-----------
E
-
M
P
--
G
--
Y
R
V
L
V
V
G
D
M
A
E
L
G
A
E
S
E
--
A
C
H
--
V
Q
V
G
E
A
A
--
K
A
A
G
I
---
D
-----
R
V
L
S
V
G
K
Q
-----------
S
------
H
A
------
I
S
T
A
S
--
G
--------
V
G
E
H
F
------
A
D
K
T
A
L
I
T
R
L
K
L
L
I
A
E
Q
Q
---
V
I
T
----
I
L
V
K
G
S
R
S
A
-
A
M
E
-
E
V
V
R
A
L
Q
---
31
HHSearch
64.56
19%
-73
- C1 -
3NRS
7
?
A:
[47-427]
-----------------------------------------------------------------------------------------------------------------------
L
L
K
P
A
P
K
I
------
F
T
V
A
G
T
N
G
K
G
T
T
C
C
T
L
E
A
I
L
-
L
A
A
G
L
R
V
-------
G
--
V
Y
---
S
S
P
H
-----
L
L
R
Y
TE
R
V
RIQ
G
Q
E
--
L
S
E
A
E
H
S
H
S
F
A
Q
I
E
A
G
R
GD
I
S
L
T
Y
F
E
F
G
T
L
S
A
L
Q
L
F
K
Q
A
K
L
D
-----
V
V
I
L
E
V
G
L
G
G
R
--
L
D
A
-
T
N
I
V
D
S
D
V
A
A
I
T
S
I
A
L
D
H
T
D
W
L
G
Y
D
R
E
S
-
I
G
R
E
K
-
A
G
V
F
R
G
----
G
K
P
A
V
-------
V
G
E
P
D
M
P
Q
S
I
A
D
V
A
A
E
L
---
G
A
Q
L
Y
R
R
DVA
W
K
F
S
Q
------------------------------
N
G
W
H
W
Q
C
G
-----
E
-
R
Q
L
-
T
G
L
P
V
P
N
-
V
P
L
A
N
A
A
T
A
L
A
V
L
H
Y
S
E
L
P
L
S
D
E
A
I
R
Q
G
L
Q
A
A
-
S
L
P
G
R
----
F
Q
V
V
S
-
E
-----------
Q
P
L
L
-
I
L
D
-
V
A
H
N
P
H
----
A
A
R
Y
L
V
N
R
L
-
A
-----------
Q
-
V
I
--
G
--
K
V
R
A
V
V
G
M
L
S
D
---
K
-----
D
I
--
A
G
T
L
A
C
L
--
S
E
R
-
V
---
D
-----
E
W
Y
C
A
P
L
E
G
PRGAS-----
A
------
G
Q
------
L
A
E
H
L
--
V
--------
S
A
R
Q
F
------
S
D
V
E
T
A
W
R
Q
A
M
Q
D
A
--
D
T
---
Q
D
V
----
V
I
V
C
G
S
F
H
T
-
V
A
H
-
V
M
A
A
L
H
L
---