@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0248: (2015-11-29 )
MKHKSEFLNFIQERGYLCQCTNIEGLDQLLLQNNYVVAYIGFDCTASSLHVGSLIQIMMLRHLQKFGYKPIVLLGGSTTKIGDPSGKDKARSVLPIEDINQNISGIKKALKKMVYFNDGKAGAIIVNNADWLDSIKYIDFLRDIGAHFSVNRMLSFDSAKTRLDREQNLSFLEFNYMLLQAYDFAELNKKYGCRLQIGGSDQWGNIVNGIELGKKLNLPELFGLTTPLLLSAQGKKMGKTESGTVWLDGDMLKPYDYWQYFRNIDDQDIGRFLRFFTDLPIDEIKKLESLKNQEINEAKKALATEVTKICHGDKEAELAQSSAVSVFENGDSSLLPDYTITKKQVANGISLIDLLHDIGLEPSKGAAKRLIQGNGCKVNDYTINDINYIINSKSFKDQSFIKLSAGKKRHIKVMVS
Atome Classification :
(30 SA)
.........10........20.......----.30........40........50........60........70........80........90........100.......110..-----------..-..----------.120.--......130.......140.......150.......160...-.-...170.......180.......190.......200.......210..-----------------..-.-.-----------------.220.......230.......-240........250.......260..----.....270.......280.....--..290..--.--....------..300.......310.......320.......330--------......------.-.340....-....350.......360.......370.......380.......390.......400.......410....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
H
K
S
E
F
L
N
F
I
Q
ERG
Y
L
C
QCT
N
I
E
G
L
D
Q
----
L
L
LQNN
Y
V
V
A
Y
IGFDCTASS
L
H
V
G
S
L
I
Q
I
M
M
L
R
H
L
Q
K
FGYK
P
I
V
L
LGGSTTKIGDPSGKDKARSVL
P
I
E
D
I
N
Q
N
I
S
G
I
K
K
A
L
K
K
M
V
-----------
Y
F-ND----------GKA
G
A
--
I
I
V
NNA
D
W
L
D
S
I
K
Y
I
D
F
L
R
D
I
G
A
HF
S
V
N
R
M
LSFD
S
A
K
T
RLD
R
-
E
-QNL
S
F
L
E
F
N
Y
M
L
L
Q
A
Y
D
F
A
E
L
N
K
KYG
C
R
L
Q
IGGSD
Q
W
G
N
I
V
N
G
I
ELGK-----------------KL-N-
L
-----------------
P
E
L
FGLTT
P
L
L
L
SAQGKKMGK-TE-S
G
T
V
W
LDGDMLK
P
Y
D
Y
W
Q
Y
F
RNI----
D
D
Q
D
I
G
R
F
L
R
F
F
TDL
P
I
D
E
I
K
K
L
--
E
S
L
--
K
N
--
Q
--
E
I
N
E
------
A
K
K
A
L
A
T
E
V
T
K
I
CHGD
K
E
A
E
L
A
Q
SS
A
V
S
V
FENGD---------SSLLPD------Y-TI
T
-
K
K
Q
V
-AN
G
I
S
L
I
D
L
L
H
DIGLEPSK
G
A
A
K
R
LIQGNG
C
K
V
N
D
Y
T
IN
D
I
N
Y
I
INSKSFKD
Q
S
F
I
K
LSAGK
K
R
H
I
K
V
M
VS
7
PsiBlast_PDB
93.34
37%
-105
- C4 -
2JAN
-
SYY_MYCTU
A:
[5-415]
------
I
L
D
E
L
S
W
R
G
L
I
A
Q
S
T
D
L
D
T
L
-
A
----
A
E
A
Q
R
G
P
M
T
V
Y
A
G
F
D
P
T
A
P
S
L
H
A
G
H
L
V
P
L
L
T
L
R
R
F
Q
R
A
G
H
R
P
I
V
L
A
G
G
A
T
G
M
I
G
D
P
R
D
V
G
E
-
R
S
L
N
E
A
D
T
V
A
E
W
T
E
R
I
R
G
Q
L
E
R
F
V
-----------
D
F
-
D
D
----------
S
P
M
G
A
--
I
V
E
N
N
L
E
W
T
G
S
L
S
A
I
E
F
L
R
D
I
G
K
H
F
S
V
N
V
M
L
A
R
D
T
I
R
R
R
L
A
G
-
E
--
G
I
S
Y
T
E
F
S
Y
L
L
L
Q
A
N
D
Y
V
E
L
H
R
R
H
G
C
T
L
Q
I
G
G
A
D
Q
W
G
N
I
I
A
G
V
R
L
V
R
-----------------
Q
K
-
L
-
G
-----------------
A
T
V
H
A
L
T
V
P
L
V
T
A
A
D
G
T
K
F
G
K
S
T
G
-
G
G
S
L
W
L
D
P
Q
M
T
S
P
Y
A
W
Y
Q
Y
F
V
N
T
----
A
D
A
D
V
I
R
Y
L
R
W
F
T
F
L
S
A
D
E
L
A
E
L
--
E
Q
A
--
T
A
--
Q
--
R
P
Q
Q
R
A
----
A
Q
R
R
L
A
S
E
L
T
V
L
V
H
G
E
A
A
T
A
A
V
E
H
A
S
R
A
L
F
G
R
G
E
LARLD
E
A
T
L
A
A
A
L
R
E
------
T
-
T
V
A
-
E
L
K
P
-
G
S
P
D
G
I
V
D
L
L
V
A
S
G
L
S
A
S
K
G
A
A
R
R
T
I
H
E
G
G
V
S
V
N
N
I
R
V
D
N
E
E
W
V
P
Q
S
S
D
F
L
H
G
R
W
L
V
L
R
R
G
K
R
S
I
A
G
V
E
R
I
29
HHSearch
92.93
37%
-102
- C4 -
2JAN
-
SYY_MYCTU
A:
[5-422]
------
I
L
D
E
L
S
W
R
G
L
I
A
Q
S
T
D
L
D
T
L
A
A
----
E
A
Q
-
R
G
P
M
T
V
Y
A
G
F
D
P
T
A
P
S
L
H
A
G
H
L
V
P
L
L
T
L
R
R
F
Q
R
A
G
H
R
P
I
V
L
A
G
G
A
T
G
M
I
G
D
P
R
D
-
V
G
E
R
S
L
N
E
A
D
T
V
A
E
W
T
E
R
I
R
G
Q
L
E
R
F
V
-----------
D
F
-
D
D
----------
S
P
M
G
A
--
I
V
E
N
N
L
E
W
T
G
S
L
S
A
I
E
F
L
R
D
I
G
K
H
F
S
V
N
V
M
L
A
R
D
T
I
R
R
R
L
A
--
G
-
E
G
I
S
Y
T
E
F
S
Y
L
L
L
Q
A
N
D
Y
V
E
L
H
R
R
H
G
C
T
L
Q
I
G
G
A
D
Q
W
G
N
I
I
A
G
V
R
L
V
R
-----------------
Q
K
-
L
-
G
-----------------
A
T
V
H
A
L
T
V
P
L
V
T
A
A
D
G
T
K
F
G
K
-
S
T
G
G
G
S
L
W
L
D
P
Q
M
T
S
P
Y
A
W
Y
Q
Y
F
V
N
T
----
A
D
A
D
V
I
R
Y
L
R
W
F
T
F
L
S
A
D
E
L
A
E
L
--
E
Q
A
--
T
A
Q
R
P
--
Q
Q
R
A
------
A
Q
R
R
L
A
S
E
L
T
V
L
V
H
G
E
A
A
T
A
A
V
E
H
A
S
R
A
L
F
G
R
G
E
---------
L
A
R
L
D
E
A
T
L
A
A
A
L
R
E
T
T
V
A
E
L
K
P
G
S
P
D
G
I
V
D
L
L
V
A
S
G
L
S
A
S
K
G
A
A
R
R
T
I
H
E
G
G
V
S
V
N
N
I
R
V
D
N
E
E
W
V
P
Q
S
S
D
F
L
H
G
R
W
L
V
L
R
R
G
K
R
S
I
A
G
V
E
R
I
22
PsiBlast_CBE
86.99
46%
-101
- C4 -
4TS1
1
SYY_GEOSE
B:
[2-310]
-----
D
L
L
A
E
L
Q
W
R
G
L
V
N
Q
T
T
D
E
D
G
L
R
K
----
L
L
N
E
E
R
-
V
T
L
Y
C
G
F
D
P
T
A
D
S
L
H
I
G
H
L
A
T
I
L
T
M
R
R
F
Q
Q
A
G
H
R
P
I
A
L
V
G
G
A
T
G
L
I
G
D
P
S
G
K
K
S
E
R
T
L
N
A
K
E
T
V
E
A
W
S
A
R
I
K
E
Q
L
G
R
F
L
-----------
D
F
-
E
A
----------
D
G
N
P
A
--
K
I
K
N
N
Y
D
W
I
G
P
L
D
V
I
T
F
L
R
D
V
G
K
H
F
S
V
N
Y
M
M
A
K
E
S
V
Q
S
R
I
---
E
-
T
G
I
S
F
T
E
F
S
Y
M
M
L
Q
A
Y
D
F
L
R
L
Y
E
T
E
G
C
R
L
Q
I
G
G
S
D
Q
W
G
N
I
T
A
G
L
E
L
I
R
-----------------
K
T
-
K
G-------------------
R
A
F
G
L
T
I
P
L
V
T
K
A
D
G
T
K
F
G
K
-
T
E
-
S
G
T
I
W
L
D
K
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
T
----
D
D
R
D
V
I
R
Y
L
K
Y
F
T
F
L
S
K
E
E
I
E
A
L
--
E
--------
Q
--
E
L
R
E
APEKRA
A
Q
K
T
L
A
E
E
V
T
K
L
V
H
G
E
E
A
L
R
---------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
86.46
46%
-99
- C4 -
1TYD
1
SYY_GEOSE
E:
[2-310]
-----
D
L
L
A
E
L
Q
W
R
G
L
V
N
Q
T
T
D
E
D
G
L
R
K
----
L
L
N
E
E
R
-
V
T
L
Y
C
G
F
D
P
T
A
D
S
L
H
I
G
H
L
A
S
I
L
T
M
R
R
F
Q
Q
A
G
H
R
P
I
A
L
V
G
G
A
T
G
L
I
G
D
P
S
G
K
K
S
E
R
T
L
N
A
K
E
T
V
E
A
W
S
A
R
I
K
E
Q
L
G
R
F
L
-----------
D
F
-
E
A
----------
D
G
N
P
A
--
K
I
K
N
N
Y
D
W
I
G
P
L
D
V
I
T
F
L
R
D
V
G
K
H
F
S
V
N
Y
M
M
A
K
E
S
V
Q
S
R
I
---
E
-
T
G
I
S
F
T
E
F
S
Y
M
M
L
Q
A
Y
D
F
L
R
L
Y
E
T
E
G
C
R
L
Q
I
G
G
S
D
Q
W
G
N
I
T
A
G
L
E
L
I
R
-----------------
K
T
-
K
G-------------------
R
A
F
G
L
T
I
P
L
V
T
K
A
D
G
T
K
F
G
K
-
T
E
-
S
G
T
I
W
L
D
K
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
T
----
D
D
R
D
V
I
R
Y
L
K
Y
F
T
F
L
S
K
E
E
I
E
A
L
--
E
--------
Q
--
E
L
R
E
APEKRA
A
Q
K
T
L
A
E
E
V
T
K
L
V
H
G
E
E
A
L
R
Q
A
I
R
I
S
---------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
86.40
46%
-97
- C4 -
1TYC
-
SYY_GEOSE
A:
[2-310]
-----
D
L
L
A
E
L
Q
W
R
G
L
V
N
Q
T
T
D
E
D
G
L
R
K
----
L
L
N
E
E
R
-
V
T
L
Y
C
G
F
D
P
T
A
D
S
L
H
I
G
H
L
A
P
I
L
T
M
R
R
F
Q
Q
A
G
H
R
P
I
A
L
V
G
G
A
T
G
L
I
G
D
P
S
G
K
K
S
E
R
T
L
N
A
K
E
T
V
E
A
W
S
A
R
I
K
E
Q
L
G
R
F
L
-----------
D
F
-
E
A
----------
D
G
N
P
A
--
K
I
K
N
N
Y
D
W
I
G
P
L
D
V
I
T
F
L
R
D
V
G
K
H
F
S
V
N
Y
M
M
A
K
E
S
V
Q
S
R
I
---
E
-
T
G
I
S
F
T
E
F
S
Y
M
M
L
Q
A
Y
D
F
L
R
L
Y
E
T
E
G
C
R
L
Q
I
G
G
S
D
Q
W
G
N
I
T
A
G
L
E
L
I
R
-----------------
K
T
-
K
G-------------------
R
A
F
G
L
T
I
P
L
V
T
K
A
D
G
T
K
F
G
K
-
T
E
-
S
G
T
I
W
L
D
K
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
T
----
D
D
R
D
V
I
R
Y
L
K
Y
F
T
F
L
S
K
E
E
I
E
A
L
--
E
--------
Q
--
E
L
R
E
APEKR
A
A
Q
K
T
L
A
E
E
V
T
K
L
V
H
G
E
E
A
L
R
Q
A
I
R
I
S
---------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
86.33
46%
-100
- C4 -
1TYA
1
SYY_GEOSE
E:
[2-310]
-----
D
L
L
A
E
L
Q
W
R
G
L
V
N
Q
T
T
D
E
D
G
L
R
K
----
L
L
N
E
E
R
-
V
T
L
Y
C
G
F
D
P
T
A
D
S
L
H
I
G
H
L
A
A
I
L
T
M
R
R
F
Q
Q
A
G
H
R
P
I
A
L
V
G
G
A
T
G
L
I
G
D
P
S
G
K
K
S
E
R
T
L
N
A
K
E
T
V
E
A
W
S
A
R
I
K
E
Q
L
G
R
F
L
-----------
D
F
-
E
A
----------
D
G
N
P
A
--
K
I
K
N
N
Y
D
W
I
G
P
L
D
V
I
T
F
L
R
D
V
G
K
H
F
S
V
N
Y
M
M
A
K
E
S
V
Q
S
R
I
---
E
-
T
G
I
S
F
T
E
F
S
Y
M
M
L
Q
A
Y
D
F
L
R
L
Y
E
T
E
G
C
R
L
Q
I
G
G
S
D
Q
W
G
N
I
T
A
G
L
E
L
I
R
-----------------
K
T
-
K
G-------------------
R
A
F
G
L
T
I
P
L
V
T
K
A
D
G
T
K
F
G
K
-
T
E
-
S
G
T
I
W
L
D
K
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
T
----
D
D
R
D
V
I
R
Y
L
K
Y
F
T
F
L
S
K
E
E
I
E
A
L
--
E
--------
Q
--
E
L
R
E
APEKRA
A
Q
K
T
L
A
E
E
V
T
K
L
V
H
G
E
E
A
L
R
Q
A
I
R
I
S
---------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
85.64
44%
-90
- C4 -
1WQ3
1
SYY_ECOLI
A:
[4-321]
----
S
N
L
I
K
Q
L
Q
E
R
G
L
V
A
Q
V
T
D
E
E
A
L
A
E
----
R
L
A
Q
G
P
-
I
A
L
V
C
G
F
D
P
T
A
D
S
L
H
L
G
H
L
V
P
L
L
C
L
K
R
F
Q
Q
A
G
H
K
P
V
A
L
V
G
G
A
T
G
L
I
G
D
P
S
F
K
A
A
E
R
K
L
N
T
E
E
T
V
Q
E
W
V
D
K
I
R
K
Q
V
A
P
F
L
-----------
D
F
-
D
C
----------
G
E
N
S
A
--
I
A
A
N
N
Y
D
W
F
G
N
M
N
V
L
T
F
L
R
D
I
G
K
H
F
S
V
N
Q
M
I
N
K
E
A
V
K
Q
R
L
N
R
-
E
D
Q
G
I
S
F
T
E
F
S
Y
N
L
L
Q
G
Y
D
F
A
C
L
N
K
Q
Y
G
V
V
L
C
I
G
G
S
D
Q
W
G
N
I
T
S
G
I
D
L
T
R
-----------------
R
L
-
H
-
Q
-----------------
N
Q
V
F
G
L
T
V
P
L
I
T
K
A
D
G
T
K
F
G
K
-
T
E
-
G
G
A
V
W
L
D
P
K
K
T
S
P
Y
K
F
Y
Q
F
W
I
N
T
----
A
D
A
D
V
Y
R
F
L
K
F
F
T
F
M
S
I
E
E
I
N
A
L
--
E
E
E
D
-
K
N
--
S
G-
K
A
P
R
------
A
Q
Y
V
L
A
E
Q
V
T
R
L
V
H
G
E
E
G
L
Q
A
A
K
R
-----------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
85.53
46%
-96
- C4 -
1TYB
1
SYY_GEOSE
E:
[2-310]
-----
D
L
L
A
E
L
Q
W
R
G
L
V
N
Q
T
T
D
E
D
G
L
R
K
----
L
L
N
E
E
R
-
V
T
L
Y
C
G
F
D
P
T
A
D
S
L
H
I
G
H
L
A
G
I
L
T
M
R
R
F
Q
Q
A
G
H
R
P
I
A
L
V
G
G
A
T
G
L
I
G
D
P
S
G
K
K
S
E
R
T
L
N
A
K
E
T
V
E
A
W
S
A
R
I
K
E
Q
L
G
R
F
L
-----------
D
F
-
E
A
----------
D
G
N
P
A
--
K
I
K
N
N
Y
D
W
I
G
P
L
D
V
I
T
F
L
R
D
V
G
K
H
F
S
V
N
Y
M
M
A
K
E
S
V
Q
S
R
I
---
E
-
T
G
I
S
F
T
E
F
S
Y
M
M
L
Q
A
Y
D
F
L
R
L
Y
E
T
E
G
C
R
L
Q
I
G
G
S
D
Q
W
G
N
I
T
A
G
L
E
L
I
R
-----------------
K
T
-
K
G-------------------
R
A
F
G
L
T
I
P
L
V
T
K
A
D
G
T
K
F
G
K
-
T
E
-
S
G
T
I
W
L
D
K
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
T
----
D
D
R
D
V
I
R
Y
L
K
Y
F
T
F
L
S
K
E
E
I
E
A
L
--
E
--------
Q
--
E
L
R
E
APEKRA
A
Q
K
T
L
A
E
E
V
T
K
L
V
H
G
E
E
A
L
R
Q
A
I
R
I
S
---------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
85.30
46%
-100
- C4 -
4TS1
1
SYY_GEOSE
A:
[2-310]
-----
D
L
L
A
E
L
Q
W
R
G
L
V
N
Q
T
T
D
E
D
G
L
R
K
----
L
L
N
E
E
R
-
V
T
L
Y
C
G
F
D
P
T
A
D
S
L
H
I
G
H
L
A
T
I
L
T
M
R
R
F
Q
Q
A
G
H
R
P
I
A
L
V
G
G
A
T
G
L
I
G
D
P
S
G
K
K
S
E
R
T
L
N
A
K
E
T
V
E
A
W
S
A
R
I
K
E
Q
L
G
R
F
L
-----------
D
F
-
E
A
----------
D
G
N
P
A
--
K
I
K
N
N
Y
D
W
I
G
P
L
D
V
I
T
F
L
R
D
V
G
K
H
F
S
V
N
Y
M
M
A
K
E
S
V
Q
S
R
I
---
E
-
T
G
I
S
F
T
E
F
S
Y
M
M
L
Q
A
Y
D
F
L
R
L
Y
E
T
E
G
C
R
L
Q
I
G
G
S
D
Q
W
G
N
I
T
A
G
L
E
L
I
R
-----------------
K
T
-
K
G-------------------
R
A
F
G
L
T
I
P
L
V
T
K
A
D
G
T
K
F
G
K
-
T
E
-
S
G
T
I
W
L
D
K
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
T
----
D
D
R
D
V
I
R
Y
L
K
Y
F
T
F
L
S
K
E
E
I
E
A
L
--
E
--------
Q
--
E
L
R
E
APEKR
A
A
Q
K
T
L
A
E
E
V
T
K
L
V
H
G
E
E
A
L
R
Q
A
I
R
Y
A
---------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
85.09
40%
-95
- C4 -
3TS1
1
SYY_GEOSE
A:
[2-319]
-----
D
L
L
A
E
L
Q
W
R
G
L
V
N
Q
T
T
D
E
D
G
L
R
K
----
L
L
N
E
E
R
-
V
T
L
Y
C
G
F
D
P
T
A
D
S
L
H
I
G
H
L
A
T
I
L
T
M
R
R
F
Q
Q
A
G
H
R
P
I
A
L
V
G
G
A
T
G
L
I
G
D
P
S
G
K
K
S
E
R
T
L
N
A
K
E
T
V
E
A
W
S
A
R
I
K
E
Q
L
G
R
F
L
-----------
D
F
-
E
A
----------
D
G
N
P
A
--
K
I
K
N
N
Y
D
W
I
G
P
L
D
V
I
T
F
L
R
D
V
G
K
H
F
S
V
N
Y
M
M
A
K
E
S
V
Q
S
R
I
---
E
-
T
G
I
S
F
T
E
F
S
Y
M
M
L
Q
A
Y
D
F
L
R
L
Y
E
T
E
G
C
R
L
Q
I
G
G
S
D
Q
W
G
N
I
T
A
G
L
E
L
I
R
-----------------
K
T
K
G
--------------------
R
A
F
G
L
T
I
P
L
V
T
K
A
D
G
T
K
F
G
K
-
T
E
-
S
G
T
I
W
L
D
K
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
T
----
D
D
R
D
V
I
R
Y
L
K
Y
F
T
F
L
S
K
E
E
I
E
A
L
--
E
--------
Q
--
E
L
R
E
APEKR
A
A
Q
K
T
L
A
E
E
V
T
K
L
V
H
G
E
E
A
L
R
Q
A
I
R
I
S
---------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
84.99
44%
-91
- C4 -
2YXN
1
SYY_ECOLI
A:
[4-321]
----
S
N
L
I
K
Q
L
Q
E
R
G
L
V
A
Q
V
T
D
E
E
A
L
A
E
----
R
L
A
Q
G
P
-
I
A
L
V
C
G
F
D
P
T
A
D
S
L
H
L
G
H
L
V
P
L
L
C
L
K
R
F
Q
Q
A
G
H
K
P
V
A
L
V
G
G
A
T
G
L
I
G
D
P
S
F
K
A
A
E
R
K
L
N
T
E
E
T
V
Q
E
W
V
D
K
I
R
K
Q
V
A
P
F
L
-----------
D
F
-
D
C
----------
G
E
N
S
A
--
I
A
A
N
N
Y
D
W
F
G
N
M
N
V
L
T
F
L
R
D
I
G
K
H
F
S
V
N
Q
M
I
N
K
E
A
V
K
Q
R
L
N
R
-
E
D
Q
G
I
S
F
T
E
F
S
Y
N
L
L
Q
G
Y
D
F
A
C
L
N
K
Q
Y
G
V
V
L
C
I
G
G
S
D
Q
W
G
N
I
T
S
G
I
D
L
T
R
-----------------
R
L
-
H
-
Q
-----------------
N
Q
V
F
G
L
T
V
P
L
I
T
K
A
D
G
T
K
F
G
K
-
T
E
-
G
G
A
V
W
L
D
P
K
K
T
S
P
Y
K
F
Y
Q
F
W
I
N
T
----
A
D
A
D
V
Y
R
F
L
K
F
F
T
F
M
S
I
E
E
I
N
A
L
--
E
E
E
D
-
K
N
--
S
G-
K
A
P
R
------
A
Q
Y
V
L
A
E
Q
V
T
R
L
V
H
G
E
E
G
L
Q
A
A
K
R
-----------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
84.82
44%
-92
- C4 -
1WQ4
1
SYY_ECOLI
A:
[3-320]
----
S
N
L
I
K
Q
L
Q
E
R
G
L
V
A
Q
V
T
D
E
E
A
L
A
E
----
R
L
A
Q
G
P
-
I
A
L
V
C
G
F
D
P
T
A
D
S
L
H
L
G
H
L
V
P
L
L
C
L
K
R
F
Q
Q
A
G
H
K
P
V
A
L
V
G
G
A
T
G
L
I
G
D
P
S
F
K
A
A
E
R
K
L
N
T
E
E
T
V
Q
E
W
V
D
K
I
R
K
Q
V
A
P
F
L
-----------
D
F
-
D
C
----------
G
E
N
S
A
--
I
A
A
N
N
Y
D
W
F
G
N
M
N
V
L
T
F
L
R
D
I
G
K
H
F
S
V
N
Q
M
I
N
K
E
A
V
K
Q
R
L
N
R
-
E
D
Q
G
I
S
F
T
E
F
S
Y
N
L
L
Q
G
Y
D
F
A
C
L
N
K
Q
Y
G
V
V
L
C
I
G
G
S
D
Q
W
G
N
I
T
S
G
I
D
L
T
R
-----------------
R
L
-
H
-
Q
-----------------
N
Q
V
F
G
L
T
V
P
L
I
T
K
A
D
G
T
K
F
G
K
-
T
E
-
G
G
A
V
W
L
D
P
K
K
T
S
P
Y
K
F
Y
Q
F
W
I
N
T
----
A
D
A
D
V
Y
R
F
L
K
F
F
T
F
M
S
I
E
E
I
N
A
L
--
E
E
E
D
-
K
N
--
S
G-
K
A
P
R
------
A
Q
Y
V
L
A
E
Q
V
T
R
L
V
H
G
E
E
G
L
Q
A
A
K
R
-----------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
84.68
45%
-91
- C4 -
1X8X
2
SYY_ECOLI
A:
[4-321]
----
S
N
L
I
K
Q
L
Q
E
R
G
L
V
A
Q
V
T
D
E
E
A
L
A
E
----
R
L
A
Q
G
P
-
I
A
L
Y
C
G
F
D
P
T
A
D
S
L
H
L
G
H
L
V
P
L
L
C
L
K
R
F
Q
Q
A
G
H
K
P
V
A
L
V
G
G
A
T
G
L
I
G
D
P
S
F
K
A
A
E
R
K
L
N
T
E
E
T
V
Q
E
W
V
D
K
I
R
K
Q
V
A
P
F
L
-----------
D
F
-
D
C
----------
G
E
N
S
A
--
I
A
A
N
N
Y
D
W
F
G
N
M
N
V
L
T
F
L
R
D
I
G
K
H
F
S
V
N
Q
M
I
N
K
E
A
V
K
Q
R
L
N
R
-
E
D
Q
G
I
S
F
T
E
F
S
Y
N
L
L
Q
G
Y
D
F
A
C
L
N
K
Q
Y
G
V
V
L
Q
I
G
G
S
D
Q
W
G
N
I
T
S
G
I
D
L
T
R
-----------------
R
L
-
H
-
Q
-----------------
N
Q
V
F
G
L
T
V
P
L
I
T
K
A
D
G
T
K
F
G
K
-
T
E
-
G
G
A
V
W
L
D
P
K
K
T
S
P
Y
K
F
Y
Q
F
W
I
N
T
----
A
D
A
D
V
Y
R
F
L
K
F
F
T
F
M
S
I
E
E
I
N
A
L
--
E
E
E
D
-
K
N
--
S
G-
K
A
P
R
------
A
Q
Y
V
L
A
E
Q
V
T
R
L
V
H
G
E
E
G
L
Q
A
A
K
R
-----------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
84.46
40%
-90
- C4 -
2TS1
-
SYY_GEOSE
A:
[2-319]
-----
D
L
L
A
E
L
Q
W
R
G
L
V
N
Q
T
T
D
E
D
G
L
R
K
----
L
L
N
E
E
R
-
V
T
L
Y
C
G
F
D
P
T
A
D
S
L
H
I
G
H
L
A
T
I
L
T
M
R
R
F
Q
Q
A
G
H
R
P
I
A
L
V
G
G
A
T
G
L
I
G
D
P
S
G
K
K
S
E
R
T
L
N
A
K
E
T
V
E
A
W
S
A
R
I
K
E
Q
L
G
R
F
L
-----------
D
F
-
E
A
----------
D
G
N
P
A
--
K
I
K
N
N
Y
D
W
I
G
P
L
D
V
I
T
F
L
R
D
V
G
K
H
F
S
V
N
Y
M
M
A
K
E
S
V
Q
S
R
I
---
E
-
T
G
I
S
F
T
E
F
S
Y
M
M
L
Q
A
Y
D
F
L
R
L
Y
E
T
E
G
C
R
L
Q
I
G
G
S
D
Q
W
G
N
I
T
A
G
L
E
L
I
R
-----------------
K
T
K
G
--------------------
R
A
F
G
L
T
I
P
L
V
T
K
A
D
G
T
K
F
G
K
-
T
E
-
S
G
T
I
W
L
D
K
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
T
----
D
D
R
D
V
I
R
Y
L
K
Y
F
T
F
L
S
K
E
E
I
E
A
L
--
E
--------
Q
--
E
L
R
E
APEKR
A
A
Q
K
T
L
A
E
E
V
T
K
L
V
H
G
E
E
A
L
R
Q
A
I
R
I
S
---------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
83.75
45%
-90
- C4 -
1VBN
1
SYY_ECOLI
A:
[6-317]
----------
L
Q
E
R
G
L
V
A
Q
V
T
D
E
E
A
L
A
E
----
R
L
A
Q
G
P
-
I
A
L
V
C
G
F
D
P
T
A
D
S
L
H
L
G
H
L
V
P
L
L
C
L
K
R
F
Q
Q
A
G
H
K
P
V
A
L
V
G
G
A
T
G
L
I
G
D
P
S
F
K
A
A
E
R
K
L
N
T
E
E
T
V
Q
E
W
V
D
K
I
R
K
Q
V
A
P
F
L
-----------
D
F
-
D
C
----------
G
E
N
S
A
--
I
A
A
N
N
Y
D
W
F
G
N
M
N
V
L
T
F
L
R
D
I
G
K
H
F
S
V
N
Q
M
I
N
K
E
A
V
K
Q
R
L
N
R
-
E
D
Q
G
I
S
F
T
E
F
S
Y
N
L
L
Q
G
Y
D
F
A
C
L
N
K
Q
Y
G
V
V
L
C
I
G
G
S
D
Q
W
G
N
I
T
S
G
I
D
L
T
R
-----------------
R
L
-
H
-
Q
-----------------
N
Q
V
F
G
L
T
V
P
L
I
T
K
A
D
G
T
K
F
G
K
-
T
E
-
G
G
A
V
W
L
D
P
K
K
T
S
P
Y
K
F
Y
Q
F
W
I
N
T
----
A
D
A
D
V
Y
R
F
L
K
F
F
T
F
M
S
I
E
E
I
N
A
L
--
E
E
E
D
-
K
N
--
S
G-
K
A
P
R
------
A
Q
Y
V
L
A
E
Q
V
T
R
L
V
H
G
E
E
G
L
Q
A
A
K
R
-----------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
83.68
46%
-90
- C4 -
1VBM
3
SYY_ECOLI
A:
[6-317]
----------
L
Q
E
R
G
L
V
A
Q
V
T
D
E
E
A
L
A
E
----
R
L
A
Q
G
P
-
I
A
L
Y
C
G
F
D
P
T
A
D
S
L
H
L
G
H
L
V
P
L
L
C
L
K
R
F
Q
Q
A
G
H
K
P
V
A
L
V
G
G
A
T
G
L
I
G
D
P
S
F
K
A
A
E
R
K
L
N
T
E
E
T
V
Q
E
W
V
D
K
I
R
K
Q
V
A
P
F
L
-----------
D
F
-
D
C
----------
G
E
N
S
A
--
I
A
A
N
N
Y
D
W
F
G
N
M
N
V
L
T
F
L
R
D
I
G
K
H
F
S
V
N
Q
M
I
N
K
E
A
V
K
Q
R
L
N
R
-
E
D
Q
G
I
S
F
T
E
F
S
Y
N
L
L
Q
G
Y
D
F
A
C
L
N
K
Q
Y
G
V
V
L
Q
I
G
G
S
D
Q
W
G
N
I
T
S
G
I
D
L
T
R
-----------------
R
L
-
H
-
Q
-----------------
N
Q
V
F
G
L
T
V
P
L
I
T
K
A
D
G
T
K
F
G
K
-
T
E
-
G
G
A
V
W
L
D
P
K
K
T
S
P
Y
K
F
Y
Q
F
W
I
N
T
----
A
D
A
D
V
Y
R
F
L
K
F
F
T
F
M
S
I
E
E
I
N
A
L
--
E
E
E
D
-
K
N
--
S
G-
K
A
P
R
------
A
Q
Y
V
L
A
E
Q
V
T
R
L
V
H
G
E
E
G
L
Q
A
A
K
R
-----------------------------------------------------------------------------------------------------------------
28
HHSearch
83.55
40%
-86
- C4 -
2TS1
-
SYY_GEOSE
A:
[1-319]
----
M
D
L
L
A
E
L
Q
W
R
G
L
V
N
Q
T
T
D
E
D
G
L
R
K
----
L
L
N
-
E
E
R
V
T
L
Y
C
G
F
D
P
T
A
D
S
L
H
I
G
H
L
A
T
I
L
T
M
R
R
F
Q
Q
A
G
H
R
P
I
A
L
V
G
G
A
T
G
L
I
G
D
P
S
G
K
K
S
E
R
T
L
N
A
K
E
T
V
E
A
W
S
A
R
I
K
E
Q
L
G
R
F
L
-----------
D
F
-
E
A
----------
D
G
N
P
A
--
K
I
K
N
N
Y
D
W
I
G
P
L
D
V
I
T
F
L
R
D
V
G
K
H
F
S
V
N
Y
M
M
A
K
E
S
V
Q
S
R
I
E
----
T
G
I
S
F
T
E
F
S
Y
M
M
L
Q
A
Y
D
F
L
R
L
Y
E
T
E
G
C
R
L
Q
I
G
G
S
D
Q
W
G
N
I
T
A
G
L
E
L
I
R
-----------------
K
T
-
K
-
G
------------------
R
A
F
G
L
T
I
P
L
V
T
K
A
D
G
T
K
F
G
K
-
T
E
-
S
G
T
I
W
L
D
K
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
T
----
D
D
R
D
V
I
R
Y
L
K
Y
F
T
F
L
S
K
E
E
I
E
A
L
--
E
Q
E
--
L
R
E
A
P
--
E
K
R
A
------
A
Q
K
T
L
A
E
E
V
T
K
L
V
H
G
E
E
A
L
R
Q
A
I
R
I
S
---------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
83.40
45%
-88
* C4 *
1VBN
1
SYY_ECOLI
B:
[6-317]
----------
L
Q
E
R
G
L
V
A
Q
V
T
D
E
E
A
L
A
E
----
R
L
A
Q
G
P
-
I
A
L
V
C
G
F
D
P
T
A
D
S
L
H
L
G
H
L
V
P
L
L
C
L
K
R
F
Q
Q
A
G
H
K
P
V
A
L
V
G
G
A
T
G
L
I
G
D
P
S
F
K
A
A
E
R
K
L
N
T
E
E
T
V
Q
E
W
V
D
K
I
R
K
Q
V
A
P
F
L
-----------
D
F
-
D
C
----------
G
E
N
S
A
--
I
A
A
N
N
Y
D
W
F
G
N
M
N
V
L
T
F
L
R
D
I
G
K
H
F
S
V
N
Q
M
I
N
K
E
A
V
K
Q
R
L
N
R
-
E
D
Q
G
I
S
F
T
E
F
S
Y
N
L
L
Q
G
Y
D
F
A
C
L
N
K
Q
Y
G
V
V
L
C
I
G
G
S
D
Q
W
G
N
I
T
S
G
I
D
L
T
R
-----------------
R
L
-
H
-
Q
-----------------
N
Q
V
F
G
L
T
V
P
L
I
T
K
A
D
G
T
K
F
G
K
-
T
E
-
G
G
A
V
W
L
D
P
K
K
T
S
P
Y
K
F
Y
Q
F
W
I
N
T
----
A
D
A
D
V
Y
R
F
L
K
F
F
T
F
M
S
I
E
E
I
N
A
L
--
E
E
E
D-
K
N
--
S
G-
K
A
P
R
------
A
Q
Y
V
L
A
E
Q
V
T
R
L
V
H
G
E
E
G
L
Q
A
A
K
R
-----------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
82.68
34%
-93
- C4 -
4OJM
1
SYYM_NEUCR
X:
[33-379]
---
K
Q
N
T
W
D
L
F
E
E
R
G
Y
V
K
D
T
A
G
T
K
E
H
I
A
----
E
L
M
R
T
R
R
I
G
A
Y
V
G
I
D
P
T
A
P
S
L
H
V
G
H
L
L
P
L
M
P
L
F
W
M
Y
L
E
G
Y
K
A
F
T
L
I
G
G
S
T
A
K
I
G
D
P
T
G
--------
S
S
S
D
A
T
M
N
M
T
K
I
H
Y
Q
L
K
K
L
W
ENVDTQMRARG
Y
E
-
A
D
----------
W
A
R
K
R
--
G
I
V
N
N
N
H
W
W
N
K
Q
P
M
L
E
V
L
R
R
V
G
H
A
L
R
I
G
P
M
L
S
R
D
T
V
K
N
K
M
T
Q
-
G
-
D
G
V
S
F
A
E
F
T
Y
P
I
M
Q
G
W
D
W
F
E
L
F
Y
Q
Q
G
V
Q
M
Q
I
G
G
S
D
Q
Y
G
N
I
I
S
G
L
E
V
V
K
AARESEPDPQERKYVTP
K
T
-
A
-
L
-----------------
D
E
C
V
G
F
T
V
P
L
L
T
D
S
S
G
A
K
F
G
K
-
S
A
-
G
N
A
I
W
L
D
P
Y
Q
T
S
V
F
D
F
Y
G
Y
F
V
R
R
----
S
D
Q
E
V
E
N
L
L
K
L
F
T
F
M
P
I
S
E
I
T
K
T
ME
E
H
I
--
K
D
--
P
--
S
K
R
V
------
A
Q
H
T
L
A
R
E
V
V
T
L
V
H
G
K
Q
E
A
S
A
A
E
D
Q
H
R
M
M
Y
T
G
Q
M
-------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
82.65
39%
-86
- C4 -
1JIK
1
SYY_STAAE
A:
[12-320]
-------------
R
G
L
I
Y
Q
Q
T
D
E
Q
G
I
E
D
----
L
L
-
N
K
E
Q
V
T
L
Y
C
G
A
D
P
T
A
D
S
L
H
I
G
H
L
L
P
F
L
T
L
R
R
F
Q
E
H
G
H
R
P
I
V
L
I
G
G
G
T
G
M
I
G
D
P
S
G
K
S
E
E
R
V
L
Q
T
E
E
Q
V
D
K
N
I
E
G
I
S
K
Q
M
H
N
I
F
-----------
E
F
-
G
T
-----------
D
H
G
A
--
V
L
V
N
N
R
D
W
L
G
Q
I
S
L
I
S
F
L
R
D
Y
G
K
H
V
G
V
N
Y
M
L
G
K
D
S
I
Q
S
R
L
---
E
-
H
G
I
S
Y
T
E
F
T
Y
T
I
L
Q
A
I
D
F
G
H
L
N
R
E
L
N
C
K
I
Q
V
G
G
S
D
Q
W
G
N
I
T
S
G
I
E
L
M
R
-----------------
R
M
Y
G
-
Q
-----------------
T
D
A
Y
G
L
T
I
P
L
V
T
K
S
D
G
K
K
F
G
K
-
S
E
-
S
G
A
V
W
L
D
A
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
Q
----
S
D
E
D
V
I
K
F
L
K
Y
F
T
F
L
G
K
E
E
I
D
R
L
--
E
Q
S
--
K
N
--
E
AP
H
L
R
E
------
A
Q
K
T
L
A
E
E
V
T
K
F
I
H
G
E
D
A
L
N
D
A
I
R
I
S
---------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
82.61
39%
-92
- C4 -
1JIL
1
SYY_STAAE
A:
[12-324]
-------------
R
G
L
I
Y
Q
Q
T
D
E
Q
G
I
E
D
----
L
L
-
N
K
E
Q
V
T
L
Y
C
G
A
D
P
T
A
D
S
L
H
I
G
H
L
L
P
F
L
T
L
R
R
F
Q
E
H
G
H
R
P
I
V
L
I
G
G
G
T
G
M
I
G
D
P
S
G
K
S
E
E
R
V
L
Q
T
E
E
Q
V
D
K
N
I
E
G
I
S
K
Q
M
H
N
I
F
-----------
E
F
-
G
T
-----------
D
H
G
A
--
V
L
V
N
N
R
D
W
L
G
Q
I
S
L
I
S
F
L
R
D
Y
G
K
H
V
G
V
N
Y
M
L
G
K
D
S
I
Q
S
R
L
---
E
-
H
G
I
S
Y
T
E
F
T
Y
T
I
L
Q
A
I
D
F
G
H
L
N
R
E
L
N
C
K
I
Q
V
G
G
S
D
Q
W
G
N
I
T
S
G
I
E
L
M
R
-----------------
R
M
Y
G
-
Q
-----------------
T
D
A
Y
G
L
T
I
P
L
V
T
K
S
D
G
K
K
F
G
K
-
S
E
-
S
G
A
V
W
L
D
A
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
Q
----
S
D
E
D
V
I
K
F
L
K
Y
F
T
F
L
G
K
E
E
I
D
R
L
--
E
Q
S
--
K
N
--
E
AP
H
L
R
E
------
A
Q
K
T
L
A
E
E
V
T
K
F
I
H
G
E
D
A
L
N
D
A
I
R
I
S
Q
A
L
F
-----------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
82.36
46%
-88
- C4 -
1VBM
3
SYY_ECOLI
B:
[6-317]
----------
L
Q
E
R
G
L
V
A
Q
V
T
D
E
E
A
L
A
E
----
R
L
A
Q
G
P
-
I
A
L
Y
C
G
F
D
P
T
A
D
S
L
H
L
G
H
L
V
P
L
L
C
L
K
R
F
Q
Q
A
G
H
K
P
V
A
L
V
G
G
A
T
G
L
I
G
D
P
S
F
K
A
A
E
R
K
L
N
T
E
E
T
V
Q
E
W
V
D
K
I
R
K
Q
V
A
P
F
L
-----------
D
F
-
D
C
----------
G
E
N
S
A
--
I
A
A
N
N
Y
D
W
F
G
N
M
N
V
L
T
F
L
R
D
I
G
K
H
F
S
V
N
Q
M
I
N
K
E
A
V
K
Q
R
L
N
R
-
E
D
Q
G
I
S
F
T
E
F
S
Y
N
L
L
Q
G
Y
D
F
A
C
L
N
K
Q
Y
G
V
V
L
Q
I
G
G
S
D
Q
W
G
N
I
T
S
G
I
D
L
T
R
-----------------
R
L
-
H
-
Q
-----------------
N
Q
V
F
G
L
T
V
P
L
I
T
K
A
D
G
T
K
F
G
K
-
T
E
-
G
G
A
V
W
L
D
P
K
K
T
S
P
Y
K
F
Y
Q
F
W
I
N
T
----
A
D
A
D
V
Y
R
F
L
K
F
F
T
F
M
S
I
E
E
I
N
A
L
--
E
E
E
D-
K
N
--
S
G-
K
A
P
R
------
A
Q
Y
V
L
A
E
Q
V
T
R
L
V
H
G
E
E
G
L
Q
A
A
K
R
-----------------------------------------------------------------------------------------------------------------
33
HHSearch
82.29
43%
-85
- C4 -
2YXN
1
SYY_ECOLI
A:
[3-322]
---
S
S
N
L
I
K
Q
L
Q
E
R
G
L
V
A
Q
V
T
D
E
E
A
L
A
E
----
R
L
A
-
Q
G
P
I
A
L
V
C
G
F
D
P
T
A
D
S
L
H
L
G
H
L
V
P
L
L
C
L
K
R
F
Q
Q
A
G
H
K
P
V
A
L
V
G
G
A
T
G
L
I
G
D
P
S
F
K
A
A
E
R
K
L
N
T
E
E
T
V
Q
E
W
V
D
K
I
R
K
Q
V
A
P
F
L
-----------
D
F
-
D
C
----------
G
E
N
S
A
--
I
A
A
N
N
Y
D
W
F
G
N
M
N
V
L
T
F
L
R
D
I
G
K
H
F
S
V
N
Q
M
I
N
K
E
A
V
K
Q
R
L
N
R
E
D
-
Q
G
I
S
F
T
E
F
S
Y
N
L
L
Q
G
Y
D
F
A
C
L
N
K
Q
Y
G
V
V
L
C
I
G
G
S
D
Q
W
G
N
I
T
S
G
I
D
L
T
R
-----------------
R
L
-
H
-
Q
-----------------
N
Q
V
F
G
L
T
V
P
L
I
T
K
A
D
G
T
K
F
G
K
-
T
E
-
G
G
A
V
W
L
-
D
---
P
K
K
T
S
P
Y
K
F
Y
Q
F
W
I
N
T
A
D
A
D
V
Y
R
F
L
K
F
F
T
F
M
S
I
E
E
I
N
A
L
--
E
E
E
--
D
K
N
S
G
--
K
A
P
R
------
A
Q
Y
V
L
A
E
Q
V
T
R
L
V
H
G
E
E
G
L
Q
A
A
K
R
-----------------------------------------------------------------------------------------------------------------
31
HHSearch
81.93
35%
-83
- C4 -
1Y42
1
SYYM_NEUCR
X:
[31-388]
-
G
K
K
Q
N
T
W
D
L
F
E
E
R
G
Y
V
K
D
T
A
G
T
K
E
H
I
A
----
E
L
M
R
T
R
R
I
G
A
Y
V
G
I
D
P
T
A
P
S
L
H
V
G
H
L
L
P
L
M
P
L
F
W
M
Y
L
E
G
Y
K
A
F
T
L
I
G
G
S
T
A
K
I
G
D
P
T
G
-----------
D
A
T
M
N
M
T
K
I
H
Y
Q
L
K
K
L
W
-----------
E
N
V
D
T
QMRARGYEAD
W
A
R
K
R
--
G
I
V
N
N
N
H
W
W
N
K
Q
P
M
L
E
V
L
R
R
V
G
H
A
L
R
I
G
P
M
L
S
R
D
T
V
K
N
K
M
T
Q
-
G
-
D
G
V
S
F
A
E
F
T
Y
P
I
M
Q
G
W
D
W
F
E
L
F
Y
Q
Q
G
V
Q
M
Q
I
G
G
S
D
Q
Y
G
N
I
I
S
G
L
E
V
V
K
-----------------
A
A
-
R
-
E
SEPDPQERKYVTPKTAL
D
E
C
V
G
F
T
V
P
L
L
T
D
S
S
G
A
K
F
G
K
-
S
A
-
G
N
A
I
W
L
D
P
Y
Q
T
S
V
F
D
F
Y
G
Y
F
V
R
R
----
S
D
Q
E
V
E
N
L
L
K
L
F
T
F
M
P
I
S
E
I
T
K
T
--
M
E
E
--
H
I
KD
P
--
S
K
R
V
------
A
Q
H
T
L
A
R
E
V
V
T
L
V
H
G
K
Q
E
A
S
A
A
E
D
Q
H
R
M
M
Y
T
G
---------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
81.80
39%
-88
- C4 -
1JII
1
SYY_STAAE
A:
[12-320]
-------------
R
G
L
I
Y
Q
Q
T
D
E
Q
G
I
E
D
----
L
L
-
N
K
E
Q
V
T
L
Y
C
G
A
D
P
T
A
D
S
L
H
I
G
H
L
L
P
F
L
T
L
R
R
F
Q
E
H
G
H
R
P
I
V
L
I
G
G
G
T
G
M
I
G
D
P
S
G
K
S
E
E
R
V
L
Q
T
E
E
Q
V
D
K
N
I
E
G
I
S
K
Q
M
H
N
I
F
-----------
E
F
-
G
T
-----------
D
H
G
A
--
V
L
V
N
N
R
D
W
L
G
Q
I
S
L
I
S
F
L
R
D
Y
G
K
H
V
G
V
N
Y
M
L
G
K
D
S
I
Q
S
R
L
---
E
-
H
G
I
S
Y
T
E
F
T
Y
T
I
L
Q
A
I
D
F
G
H
L
N
R
E
L
N
C
K
I
Q
V
G
G
S
D
Q
W
G
N
I
T
S
G
I
E
L
M
R
-----------------
R
M
Y
G
-
Q
-----------------
T
D
A
Y
G
L
T
I
P
L
V
T
K
S
D
G
K
K
F
G
K
-
S
E
-
S
G
A
V
W
L
D
A
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
Q
----
S
D
E
D
V
I
K
F
L
K
Y
F
T
F
L
G
K
E
E
I
D
R
L
--
E
Q
S
--
K
N
--
E
AP
H
L
R
E
------
A
Q
K
T
L
A
E
E
V
T
K
F
I
H
G
E
D
A
L
N
D
A
I
R
I
S
---------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
81.00
39%
-94
- C4 -
1JIJ
1
SYY_STAAE
A:
[12-320]
-------------
R
G
L
I
Y
Q
Q
T
D
E
Q
G
I
E
D
----
L
L
-
N
K
E
Q
V
T
L
Y
C
G
A
D
P
T
A
D
S
L
H
I
G
H
L
L
P
F
L
T
L
R
R
F
Q
E
H
G
H
R
P
I
V
L
I
G
G
G
T
G
M
I
G
D
P
S
G
K
S
E
E
R
V
L
Q
T
E
E
Q
V
D
K
N
I
E
G
I
S
K
Q
M
H
N
I
F
-----------
E
F
-
G
T
-----------
D
H
G
A
--
V
L
V
N
N
R
D
W
L
G
Q
I
S
L
I
S
F
L
R
D
Y
G
K
H
V
G
V
N
Y
M
L
G
K
D
S
I
Q
S
R
L
---
E
-
H
G
I
S
Y
T
E
F
T
Y
T
I
L
Q
A
I
D
F
G
H
L
N
R
E
L
N
C
K
I
Q
V
G
G
S
D
Q
W
G
N
I
T
S
G
I
E
L
M
R
-----------------
R
M
Y
G
-
Q
-----------------
T
D
A
Y
G
L
T
I
P
L
V
T
K
S
D
G
K
K
F
G
K
-
S
E
-
S
G
A
V
W
L
D
A
E
K
T
S
P
Y
E
F
Y
Q
F
W
I
N
Q
----
S
D
E
D
V
I
K
F
L
K
Y
F
T
F
L
G
K
E
E
I
D
R
L
--
E
Q
S
--
K
N
--
E
AP
H
L
R
E
------
A
Q
K
T
L
A
E
E
V
T
K
F
I
H
G
E
D
A
L
N
D
A
I
R
I
S
---------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
80.88
34%
-92
- C4 -
1Y42
1
SYYM_NEUCR
X:
[33-379]
---
K
Q
N
T
W
D
L
F
E
E
R
G
Y
V
K
D
T
A
G
T
K
E
H
I
A
----
E
L
M
R
T
R
R
I
G
A
Y
V
G
I
D
P
T
A
P
S
L
H
V
G
H
L
L
P
L
M
P
L
F
W
M
Y
L
E
G
Y
K
A
F
T
L
I
G
G
S
T
A
K
I
G
D
P
T
G
-----------
D
A
T
M
N
M
T
K
I
H
Y
Q
L
K
K
L
W
ENVDTQMRARG
Y
E
-
A
D
----------
W
A
R
K
R
--
G
I
V
N
N
N
H
W
W
N
K
Q
P
M
L
E
V
L
R
R
V
G
H
A
L
R
I
G
P
M
L
S
R
D
T
V
K
N
K
M
T
Q
-
G
-
D
G
V
S
F
A
E
F
T
Y
P
I
M
Q
G
W
D
W
F
E
L
F
Y
Q
Q
G
V
Q
M
Q
I
G
G
S
D
Q
Y
G
N
I
I
S
G
L
E
V
V
K
AARESEPDPQERKYVTP
K
T
-
A
-
L
-----------------
D
E
C
V
G
F
T
V
P
L
L
T
D
S
S
G
A
K
F
G
K
-
S
A
-
G
N
A
I
W
L
D
P
Y
Q
T
S
V
F
D
F
Y
G
Y
F
V
R
R
----
S
D
Q
E
V
E
N
L
L
K
L
F
T
F
M
P
I
S
E
I
T
K
T
ME
E
H
I
--
K
D
--
P
--
S
K
R
V
------
A
Q
H
T
L
A
R
E
V
V
T
L
V
H
G
K
Q
E
A
S
A
A
E
D
Q
H
R
M
M
Y
T
G
---------------------------------------------------------------------------------------------------------
32
HHSearch
78.24
35%
-90
- C4 -
2PID
1
SYYM_HUMAN
A:
[10-346]
-----
G
L
L
A
A
Q
K
A
R
G
L
F
K
D
F
F
P
E
T
G
T
K
I
ELPE
L
F
----
P
Q
T
I
Y
C
G
F
D
P
T
A
D
S
L
H
V
G
H
L
L
A
L
L
G
L
F
H
L
Q
R
A
G
H
N
V
I
A
L
V
G
G
A
T
A
R
L
G
D
P
S
G
R
T
K
E
R
E
A
L
E
T
E
R
V
R
A
N
A
R
A
L
R
L
G
L
E
A
L
A
A
----------
N
H
-
Q
Q
LFTDGR----
S
W
G
S
F
--
T
V
L
D
N
S
A
W
Y
Q
K
Q
H
L
V
D
F
L
A
A
V
G
G
H
F
R
M
G
T
L
L
S
R
Q
S
V
Q
L
R
L
K
S
-
P
-
E
G
M
S
L
A
E
F
F
Y
Q
V
L
Q
A
Y
D
F
Y
Y
L
F
Q
R
Y
G
C
R
V
Q
L
G
G
S
D
Q
L
G
N
I
M
S
G
Y
E
F
I
N
-----------------
K
L
-
T
-
G
-----------------
E
D
V
F
G
I
T
V
P
L
I
T
---------------
A
V
W
L
N
R
D
K
T
S
P
F
E
L
Y
Q
F
F
V
R
Q
----
P
D
D
S
V
E
R
Y
L
K
L
F
T
F
L
P
L
P
E
I
D
H
I
--
M
Q
L
--
H
V
K
E
P
--
E
R
R
G
------
P
Q
K
R
L
A
A
E
V
T
K
L
V
H
G
R
E
G
L
D
S
A
K
R
C
T
Q
A
L
------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
74.79
38%
-83
- C4 -
2PID
1
SYYM_HUMAN
B:
[50-346]
------------------------------------------
Y
C
G
F
D
P
T
A
D
S
L
H
V
G
H
L
L
A
L
L
G
L
F
H
L
Q
R
A
G
H
N
V
I
A
L
V
G
G
A
T
A
R
L
G
D
P
S
G
R
T
K
E
R
E
A
L
E
T
E
R
V
R
A
N
A
R
A
L
R
L
G
L
E
A
L
A
A
N
H
Q
Q
------
L
F
-
T
D
----------
G
R
S
W
G
S
F
T
V
L
D
N
S
A
W
Y
Q
K
Q
H
L
V
D
F
L
A
A
V
G
G
H
F
R
M
G
T
L
L
S
R
Q
S
V
Q
L
R
L
K
S
-
P
-
E
G
M
S
L
A
E
F
F
Y
Q
V
L
Q
A
Y
D
F
Y
Y
L
F
Q
R
Y
G
C
R
V
Q
L
G
G
S
D
Q
L
G
N
I
M
S
G
Y
E
F
I
N
-----------------
K
L
-
T
-
G
-----------------
E
D
V
F
G
I
T
V
P
L
I
T
---------------
A
V
W
L
N
R
D
K
T
S
P
F
E
L
Y
Q
F
F
V
R
Q
----
P
D
D
S
V
E
R
Y
L
K
L
F
T
F
L
P
L
P
E
I
D
H
I
--
M
Q
L
H
V
K
E
--
P
--
E
R
R
G
------
P
Q
K
R
L
A
A
E
V
T
K
L
V
H
G
R
E
G
L
D
S
A
K
R
C
T
Q
A
L
------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
74.73
38%
-81
- C4 -
2PID
1
SYYM_HUMAN
A:
[50-346]
------------------------------------------
Y
C
G
F
D
P
T
A
D
S
L
H
V
G
H
L
L
A
L
L
G
L
F
H
L
Q
R
A
G
H
N
V
I
A
L
V
G
G
A
T
A
R
L
G
D
P
S
G
R
T
K
E
R
E
A
L
E
T
E
R
V
R
A
N
A
R
A
L
R
L
G
L
E
A
L
A
A
N
H
Q
Q
------
L
F
-
T
D
----------
G
R
S
W
G
S
F
T
V
L
D
N
S
A
W
Y
Q
K
Q
H
L
V
D
F
L
A
A
V
G
G
H
F
R
M
G
T
L
L
S
R
Q
S
V
Q
L
R
L
K
S
-
P
-
E
G
M
S
L
A
E
F
F
Y
Q
V
L
Q
A
Y
D
F
Y
Y
L
F
Q
R
Y
G
C
R
V
Q
L
G
G
S
D
Q
L
G
N
I
M
S
G
Y
E
F
I
N
-----------------
K
L
-
T
-
G
-----------------
E
D
V
F
G
I
T
V
P
L
I
T
---------------
A
V
W
L
N
R
D
K
T
S
P
F
E
L
Y
Q
F
F
V
R
Q
----
P
D
D
S
V
E
R
Y
L
K
L
F
T
F
L
P
L
P
E
I
D
H
I
--
M
Q
L
H
V
K
E
--
P
--
E
R
R
G
------
P
Q
K
R
L
A
A
E
V
T
K
L
V
H
G
R
E
G
L
D
S
A
K
R
C
T
Q
A
L
------------------------------------------------------------------------------------------------------------