@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0257: (2015-11-29 )
MNLKAQYQDHLLFYRLGDFYELFFDDAIKAAKLLNIVLTKRGNSYGQEVPMCGVPAHSSESYLHKLIDLGFKVAICDQLETADEAKRRGYKSIVKRDVVRIVTPGTIVEDSLLEDKNNNYLASIVKQNGEYAIGWLELSTGKFFHTLTNLKALDSDLLRISPKELLISDELAEDEKIRSILKNYKISITQHAQSFFEYNKSNRTLCEFYKVRELGVIGSFSKVEIMACGALLEYVKVTQRGSVPRLELPEPYKQQNFMLVDASARRNLELFLTQFGEKKGSLISVIDHTVTASGGRLLKQMLASPLACSKAINLRLSTVEFFVNNYESRKRIREILSNIPDIERSLSRLMLERGSPKDINLLKVGLGKTLELSEFLYKIESGKNESLLQQYVIPVLDTGIQPALNAEITVKSDENELSTIYKSLGNHKDLFELLNSAMLDNNLSSVKEGGFINPKYNQELSELSYVLSNSNKLITRLRESYRDLTGIAALKILHNNMLGYYIEVSANHKITSDIFIHRQSLANSMRYTTNELKELENKILTARDAVISLEIKIFGELCSEIAKESERIALTANALAKLDIRTAFAELAVQNDYTKPIINDSKEFNICNGRHPVVEVNDKFIANSINLSGIHLITGPNMAGKSTFLRQNALIAILAHMGSFVPADSAHIGVIDKIFSRVGATDNITAGYSTFMVEMIETATIVNQATDRSLVILDEIGRGTGVYDGLSIAQAVIEHIHNVNKCRAIFATHYHELTKVSKYLKSVKCFCVRIKEWKEEVIFLHEVVEGVADESYGIHVAKLAGFPDSILNRASEVFKELKA
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.-.....-.150.......160.......170.......180.......190.......200.......210......-.220........230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510...-.....520.......530.......540.......550.......560.......570.......580.......590.......600.......610...--.--...620......--.---630--........640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNLK
A
Q
YQD
H
L
L
F
Y
R
L
G
D
F
Y
E
L
F
F
D
D
A
I
K
A
A
K
L
L
N
I
V
L
TKRGNSYGQEVPMCGVPAHS
S
E
S
Y
L
H
K
L
I
DLG
F
K
V
A
ICDQL
E
T
A
D
E
A
K
R
R
G
Y
K
S
I
V
K
R
D
V
V
R
IVTPGTIV
E
D
S
L
LEDKNN
N
Y
L
A
S
I
V
KQNG
E
Y
A
I
G
W
L
ELSTG
K
F
-
F
H
T
L
T
-
N
L
K
A
L
D
S
D
L
LRI
S
P
K
E
LLI
S
D
ELA
E
D
E
K
I
R
S
I
L
K
NY
K
I
S
I
T
Q
H
A
Q
S
F
F
E
YNKSN
R
T
L
C
E
F
Y
K
V
RELGVIG-SF-
S
K
V
E
I
M
A
C
G
A
L
L
E
Y
V
K
V
TQRGSVPRLELPEPYKQQ
N
F
M
L
V
DASARR
N
L
E
L
F
L
T
Q
FGEKKG
S
L
I
S
V
I
DHTVTAS
G
G
R
L
L
K
Q
M
L
ASPL
A
C
S
K
A
I
N
L
R
L
S
T
V
E
F
F
V
N
N
Y
E
S
R
K
R
I
R
E
I
L
SNIP
D
I
E
R
S
L
S
R
L
M
LERGSPKD
I
N
L
L
K
VGLGKTL
E
L
S
E
F
L
Y
K
IESGK
N
E
S
L
L
Q
Q
Y
V
I
P
V
L
DTGIQPALN
A
E
I
T
V
KSDE
N
E
L
S
T
I
Y
K
S
LG
N
H
K
D
L
F
E
L
L
N
S
A
M
LDN
N
L
S
S
V
KEGGFIN
P
K
Y
N
Q
E
L
S
E
L
S
Y
V
LSN
S
N
K
L
I
T
R
L
R
E
S
Y
R
D
L
T
G
I
A
A
L
K
I
L
HNNM
L
G
Y
Y
I
E
V
SANHKI-
T
S
D
I
-
F
I
H
R
Q
S
L
A
N
S
MRY
T
T
N
E
L
K
E
L
E
N
K
I
L
TAR
D
A
V
I
S
L
E
I
K
I
F
G
E
L
C
S
E
I
A
K
ES
E
R
I
A
L
T
A
N
A
L
A
K
L
D
I
R
T
A
F
A
E
L
A
VQNDYTKPIINDSKEFNICNGRH
P
V
V
E
--V--ND
K
F
IANSINL
S
--
G
---
I
H
---
L
ITGPNMAG
K
S
T
F
L
R
Q
N
A
L
I
A
I
L
A
H
MGSFVPADSAH
I
G
V
I
D
K
I
F
S
RVGATDNITA
G
Y
S
T
F
M
V
E
M
I
E
T
A
T
I
V
NQATD
R
S
L
V
I
L
DEIGRGTGVYD
G
L
S
I
A
Q
A
V
I
E
H
I
H
N
V
N
K
C
R
A
I
F
A
T
H
Y
H
E
L
T
K
V
S
K
Y
L
K
S
V
K
C
F
C
V
R
I
K
E
W
K
E
E
V
I
F
L
H
E
V
V
E
G
VADESYG
I
H
V
A
K
LAGF
P
D
S
I
L
N
R
A
S
E
V
F
K
E
LKA
34
HHSearch
97.54
39%
-91
- C6 -
1WB9
4
MUTS_ECOLI
A:
[18-798]
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
T
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
K
R
G
A
S
A
G
E
P
I
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
I
G
D
P
A
T
-----
S
K
G
P
V
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
-
R
L
S
E
P
A
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
----
E
-
G
R
R
G
L
R
R
R
P
L
W
E
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
-
V
E
N
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
---
T
A
G
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
---------------------------------
S
A
P
V
Q
A
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
-
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
--
Q
V
L
N
E
P
F
I
A
N
P
L
N
L
S
PQ
R
R--
M
L
---
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
-----------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
8
PsiBlast_PDB
97.48
37%
-92
- C6 -
3K0S
3
MUTS_ECOLI
A:
[17-797]
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
K
R
G
A
S
A
G
E
P
I
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
I
--
G
D
P
A
T
S
K
G
---
P
V
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
-
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
L
R
R
R
P
L
W
E
-----
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
-
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
T
A
G
---
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
S
A
P
V
Q
A
L
R
E
K
---------------------------------
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
-
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
--
N
E
P
F
I
A
N
P
L
N
L
S
--
P
QRR
M
L
---
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
------------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
N
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
10
PsiBlast_PDB
97.04
37%
-90
- C6 -
1WB9
4
MUTS_ECOLI
A:
[18-798]
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
T
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
K
R
G
A
S
A
G
E
P
I
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
I
--
G
D
P
A
T
S
K
G
---
P
V
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
-
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
L
R
R
R
P
L
W
E
-----
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
-
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
T
A
G
---
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
S
A
P
V
Q
A
L
R
E
K
---------------------------------
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
-
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
--
N
E
P
F
I
A
N
P
L
N
L
S
--
P
QRR
M
L
---
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
-----------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
5
PsiBlast_PDB
96.85
37%
-92
- C6 -
2WTU
5
MUTS_ECOLI
A:
[18-798]
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
K
R
G
A
S
A
G
E
P
I
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
I
--
G
D
P
A
T
S
K
G
---
P
V
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
-
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
L
R
R
R
P
L
W
E
-----
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
-
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
T
A
G
---
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
S
A
P
V
Q
A
L
R
E
K
---------------------------------
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
-
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
--
N
E
P
F
I
A
N
P
L
N
L
S
--
P
QRR
M
L
---
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
A
A
D
--------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
2
PsiBlast_PDB
96.85
37%
-90
- C6 -
1OH6
4
MUTS_ECOLI
A:
[18-798]
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
K
R
G
A
S
A
G
E
P
I
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
I
--
G
D
P
A
T
S
K
G
---
P
V
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
-
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
L
R
R
R
P
L
W
E
-----
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
-
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
T
A
G
---
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
S
A
P
V
Q
A
L
R
E
K
---------------------------------
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
-
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
--
N
E
P
F
I
A
N
P
L
N
L
S
--
P
QRR
M
L
---
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
-----------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
9
PsiBlast_PDB
96.72
37%
-91
- C6 -
1WBB
4
MUTS_ECOLI
A:
[18-798]
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
A
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
K
R
G
A
S
A
G
E
P
I
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
I
--
G
D
P
A
T
S
K
G
---
P
V
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
-
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
L
R
R
R
P
L
W
E
-----
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
-
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
T
A
G
---
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
S
A
P
V
Q
A
L
R
E
K
---------------------------------
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
-
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
--
N
E
P
F
I
A
N
P
L
N
L
S
--
P
QRR
M
L
---
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
-----------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
28
PsiBlast_CBE
96.68
37%
-91
- C6 -
1WBD
2
MUTS_ECOLI
B:
[18-798]
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
Q
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
----------
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
------------------
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
-
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
L
R
R
R
P
L
W
E
-----
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
-
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
T
A
G
---
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
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L
A
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M
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A
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Q
L
P
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L
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A
Q
L
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T
V
D
S
A
P
V
Q
A
L
R
E
K
---------------------------------
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
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D
G
G
V
I
A
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G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
-
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
--
N
E
P
F
I
A
N
P
L
N
L
S
--
P
QRR
M
L
---
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
----------
T
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
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H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
30
PsiBlast_CBE
96.59
37%
-90
- C6 -
1WBB
2
MUTS_ECOLI
B:
[18-798]
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
A
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
----------
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
------------------
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
-
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
L
R
R
R
P
L
W
E
-----
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
-
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
T
A
G
---
L
Q
P
V
L
R
Q
V
G
D
L
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R
I
L
A
R
L
A
L
R
T
A
R
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L
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R
M
R
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A
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L
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L
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A
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L
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T
V
D
S
A
P
V
Q
A
L
R
E
K
---------------------------------
M
G
E
F
A
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L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
-
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
--
N
E
P
F
I
A
N
P
L
N
L
S
--
P
QRR
M
L
---
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
----------
T
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
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H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
25
PsiBlast_CBE
96.59
37%
-93
- C6 -
1OH7
2
MUTS_ECOLI
B:
[18-798]
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
----------
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
------------------
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
-
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
L
R
R
R
P
L
W
E
-----
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
-
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
T
A
G
---
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
S
A
P
V
Q
A
L
R
E
K
---------------------------------
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
-
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
--
N
E
P
F
I
A
N
P
L
N
L
S
--
P
QRR
M
L
---
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
----------
T
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
31
PsiBlast_CBE
96.46
37%
-89
- C6 -
1WB9
2
MUTS_ECOLI
B:
[18-798]
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
T
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
----------
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
------------------
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
-
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
L
R
R
R
P
L
W
E
-----
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
-
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
T
A
G
---
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
S
A
P
V
Q
A
L
R
E
K
---------------------------------
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
-
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
--
N
E
P
F
I
A
N
P
L
N
L
S
--
P
QRR
M
L
---
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
----------
T
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
7
PsiBlast_PDB
96.46
37%
-91
- C6 -
1WBD
4
MUTS_ECOLI
A:
[18-798]
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
Q
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
K
R
G
A
S
A
G
E
P
I
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
I
--
G
D
P
A
T
S
K
G
---
P
V
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
-
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
L
R
R
R
P
L
W
E
-----
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
-
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
T
A
G
---
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
S
A
P
V
Q
A
L
R
E
K
---------------------------------
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
-
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
--
N
E
P
F
I
A
N
P
L
N
L
S
--
P
QRR
M
L
---
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
-----------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
24
PsiBlast_CBE
96.28
37%
-93
- C6 -
1OH8
2
MUTS_ECOLI
B:
[18-798]
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
----------
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
------------------
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
-
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
L
R
R
R
P
L
W
E
-----
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
-
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
T
A
G
---
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
S
A
P
V
Q
A
L
R
E
K
---------------------------------
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
-
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
--
N
E
P
F
I
A
N
P
L
N
L
S
--
P
QRR
M
L
---
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
----------
T
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
6
PsiBlast_PDB
96.14
37%
-91
- C6 -
3ZLJ
2
MUTS_ECOLI
A:
[18-798]
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
K
R
G
A
S
A
G
E
P
I
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
I
--
G
D
P
A
T
S
K
G
---
P
V
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
-
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
L
R
R
R
P
L
W
E
-----
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
-
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
T
A
G
---
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
S
A
P
V
Q
A
L
R
E
K
---------------------------------
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
-
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
--
N
E
P
F
I
A
N
P
L
N
L
S
--
P
QRR
M
L
---
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
------------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
---------
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
3
PsiBlast_PDB
96.07
37%
-91
- C6 -
1OH7
4
MUTS_ECOLI
A:
[18-798]
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
K
R
G
A
S
A
G
E
P
I
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
I
--
G
D
P
A
T
S
K
G
---
P
V
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
-
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
L
R
R
R
P
L
W
E
-----
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
-
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
T
A
G
---
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
S
A
P
V
Q
A
L
R
E
K
---------------------------------
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
-
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
--
N
E
P
F
I
A
N
P
L
N
L
S
--
P
QRR
M
L
---
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
-----------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
27
PsiBlast_CBE
96.05
37%
-92
- C6 -
1OH5
2
MUTS_ECOLI
B:
[18-798]
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
----------
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
------------------
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
-
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
L
R
R
R
P
L
W
E
-----
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
-
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
T
A
G
---
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
S
A
P
V
Q
A
L
R
E
K
---------------------------------
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
-
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
--
N
E
P
F
I
A
N
P
L
N
L
S
--
P
QRR
M
L
---
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
----------
T
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
29
PsiBlast_CBE
96.00
37%
-90
- C6 -
3K0S
2
MUTS_ECOLI
B:
[17-797]
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
----------
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
----------------
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
-
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
L
R
R
R
P
L
W
E
-----
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
-
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
T
A
G
---
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
S
A
P
V
Q
A
L
R
E
K
---------------------------------
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
-
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
--
N
E
P
F
I
A
N
P
L
N
L
S
--
P
QRR
M
L
---
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
---------
S
T
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
N
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
23
PsiBlast_CBE
95.99
37%
-88
- C6 -
1W7A
4
MUTS_ECOLI
B:
[18-798]
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
----------
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
------------------
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
-
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
L
R
R
R
P
L
W
E
-----
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
-
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
T
A
G
---
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
S
A
P
V
Q
A
L
R
E
K
---------------------------------
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
-
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
--
N
E
P
F
I
A
N
P
L
N
L
S
--
P
QRR
M
L
---
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
A
A
D
D
--
S
G
R
S
T
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
4
PsiBlast_PDB
95.94
37%
-88
- C6 -
1OH8
4
MUTS_ECOLI
A:
[18-798]
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
K
R
G
A
S
A
G
E
P
I
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
I
--
G
D
P
A
T
S
K
G
---
P
V
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
-
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
L
R
R
R
P
L
W
E
-----
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
-
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
T
A
G
---
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
S
A
P
V
Q
A
L
R
E
K
---------------------------------
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
-
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
QV
L
--
N
E
P
F
I
A
N
P
L
N
L
S
--
P
QRR
M
L
---
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
-----------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
11
PsiBlast_PDB
95.84
36%
-87
- C6 -
1E3M
5
MUTS_ECOLI
A:
[18-798]
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
K
R
G
A
S
A
G
E
P
I
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
I
--
G
D
P
A
T
S
K
G
---
P
V
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
-
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
L
R
R
R
P
L
W
E
-----
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
-
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
T
A
G
---
L
Q
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
E
T
V
D
S
A
P
V
Q
A
L
R
E
K
---------------------------------
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
D
T
P
P
V
L
V
R
D
G
G
V
I
A
S
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L
D
T
L
K
V
G
F
N
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
-
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
N
Y
T
C
P
T
F
I
D
K
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
--
N
E
P
F
I
A
N
P
L
N
L
S
--
P
---
Q
R
RML
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
V
E
I
G
P
I
D
R
I
F
T
R
V
G
-----------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
P
E
K
M
E
G
V
A
N
V
H
L
D
A
L
E
H
G
D
T
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
1
PsiBlast_PDB
95.73
37%
-90
- C6 -
1OH5
4
MUTS_ECOLI
A:
[18-798]
L
R
L
K
A
Q
H
P
E
I
L
L
F
Y
R
M
G
D
F
Y
E
L
F
Y
D
D
A
K
R
A
S
Q
L
L
D
I
S
L
T
K
R
G
A
S
A
G
E
P
I
P
M
A
G
I
P
Y
H
A
V
E
N
Y
L
A
K
L
V
N
Q
G
E
S
V
A
I
C
E
Q
I
--
G
D
P
A
T
S
K
G
---
P
V
E
R
K
V
V
R
I
V
T
P
G
T
I
S
D
E
A
L
L
Q
E
R
Q
D
N
L
L
A
A
I
W
Q
D
S
K
G
F
G
Y
A
T
L
D
I
S
S
G
R
F
R
L
S
E
P
A
-
D
R
E
T
M
A
A
E
L
Q
R
T
N
P
A
E
L
L
Y
A
E
D
F
A
E
M
S
L
I
E
G
R
R
G
L
R
R
R
P
L
W
E
-----
F
E
I
D
T
A
R
Q
Q
L
N
L
Q
F
G
T
R
D
L
V
G
F
G
V
E
N
-
A
P
R
G
L
C
A
A
G
C
L
L
Q
Y
A
K
D
T
Q
R
T
T
L
P
H
I
R
S
I
T
M
E
R
E
Q
D
S
I
I
M
D
A
A
T
R
R
N
L
E
I
T
Q
N
L
A
G
G
A
E
N
T
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
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V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
T
A
G
---
L
Q
P
V
L
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A
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Q
A
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R
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K
---------------------------------
M
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Y
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I
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I
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H
-
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A
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V
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--
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E
P
F
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A
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L
N
L
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--
P
QRR
M
L
---
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
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A
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A
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Y
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R
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T
R
V
G
-----------
F
M
V
E
M
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S
21
PsiBlast_CBE
94.37
37%
-90
- C6 -
3ZLJ
2
MUTS_ECOLI
B:
[26-798]
--------
E
I
L
L
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--------------------
A
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E
-----------------
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-----
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---
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---------------------------------
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