@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0267: (2015-11-29 )
MSLLEADPIYKPFNYPWAYDAWLQQQRIHWIPEEVPLADDVKDWKIKLLNVEKNLLTQIFRFFTQADIEVNNCYMRHYSNIFKPTEICMMLASFSNMETIHIAAYSYLLDTIGMPESEYQAFLKYDAMRKKYEYMLEFEESKKHDKKHVAKTLAVFGAFTEGLQLFASFAILLNFQRFGKMKGMGQIIAWSARDETLHTNSIINLFNTFIKENNEIWNDEFKEGLYSACRTIVGLEDEFIKLAFDLGDVEGLSAEEVRNYIRYIANRRLMQLGLKPIYDINDNPLPWLDEILNGVEHTNFFENRVTEYSRAATQGTWEEAFTEDDTNNKER
Atome Classification :
(20 SA)
........---.10........20........30........40.....-.-..50........60........70.........80........90........100.......110....-.---.----.---.--120...----...---.130.....---------..140.--------------------------.--.....150.---......160.......170.......180.......190.......200.......210--....--...220.......230.......240......-.250.......260.......270..-.....280........290.......300.......310.......320.......330
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSLLEADP---IYKPFNYP
W
A
Y
D
A
W
L
Q
Q
Q
R
IHWIPEEVPLADDVKD
W
K
I
-
K
-
L
L
NV
E
K
N
L
L
T
Q
I
F
R
F
F
T
QAD
I
E
V
-
N
N
C
Y
M
R
H
Y
S
N
IF
K
P
T
E
I
C
M
M
L
A
S
FSN
M
E
T
I
H
I
A
A
Y
S
Y
L
L
D
T-IGM
P
-
E
---
S
----
E
---
Y
--
Q
A
F
L
K
Y
----
D
A
M
---
R
K
K
Y
E
Y
M
L
E
---------
F
E
E
SKK--------------------------H--
D
K
K
H
V
A
K
T
L
---
A
V
F
G
A
F
T
E
G
L
Q
L
F
A
S
F
A
I
L
L
N
F
Q
R
F
GKMKGMG
Q
I
I
A
WSARDETLH
T
N
S
I
I
N
L
F
N
T
F
I
KE--NNEI--W
N
D
E
F
K
E
G
L
Y
S
A
C
R
T
I
VGL
E
D
E
F
I
K
L
A
FDLGD-VEGL
S
A
E
E
V
R
N
Y
I
R
Y
I
A
N
R
R
L
M
Q
LGL-
K
P
IYDI-NDNP
L
P
W
L
D
E
I
L
N
GVEH
T
N
F
F
E
N
R
V
T
E
Y
S
RAATQG
T
W
E
EAFTEDDTNNKER
5
PsiBlast_PDB
92.55
30%
-105
- C3 -
4M1I
3
RIR2_CHLTR
A:
[53-347]
--------------
P
I
K
Y
K
W
A
W
E
H
Y
L
N
G
C
A
N
N
W
L
P
T
E
I
P
M
G
K
D
I
E
L
W
K
S
D
R
-
L
S
E
D
E
R
R
V
I
L
L
N
L
G
F
F
S
T
A
E
S
L
V
G
N
N
I
V
L
A
I
F
K
H
V
T
N
P
-
E
A
R
Q
Y
L
L
R
Q
A
F
E
E
A
V
H
T
H
T
F
L
Y
I
C
E
S
-
L
G
L
D
-
E
---
K
----
E
I
--
F
--
N
A
Y
N
E
R
----
A
A
I
---
K
A
K
D
D
F
Q
M
E
I
TGKVLDPN
F
R
T
D
S
V
--------------------------
E
--
G
L
Q
E
F
V
K
N
L
---
V
G
Y
Y
I
I
M
E
G
I
F
F
Y
S
G
F
V
M
I
L
S
F
H
R
Q
N
K
M
I
G
I
G
E
Q
Y
Q
Y
I
L
R
D
E
T
I
H
L
N
F
G
I
D
L
I
N
G
I
K
E
E
--
N
P
E
I
--
W
T
P
E
L
Q
Q
E
I
V
E
L
I
K
R
A
V
D
L
E
I
E
Y
A
Q
D
C
L
P
R
G
--
I
L
G
L
R
A
S
M
F
I
D
Y
V
Q
H
I
A
D
R
R
L
E
R
I
G
L
-
K
P
I
Y
H
--
T
K
N
P
F
P
W
M
S
E
T
I
D
L
N
K
E
----------------------------------
2
PsiBlast_PDB
92.42
30%
-106
- C3 -
4D8F
5
RIR2_CHLTR
A:
[53-340]
--------------
P
I
K
Y
K
W
A
W
E
H
Y
L
N
G
C
A
N
N
W
L
P
T
E
I
P
M
G
K
D
I
E
L
W
K
S
D
R
-
L
S
E
D
E
R
R
V
I
L
L
N
L
G
F
F
S
T
A
E
S
L
V
G
N
N
I
V
L
A
I
F
K
H
V
T
N
P
-
E
A
R
Q
Y
L
L
R
Q
A
F
E
E
A
V
H
T
H
T
F
L
Y
I
C
E
S
-
L
G
L
D
-
E
---
K
----
E
I
--
F
--
N
A
Y
N
E
R
----
A
A
I
---
K
A
K
D
D
F
Q
M
E
I
T
GKVLDPN
F
R
T
D
S
V
--------------------------
E
--
G
L
Q
E
F
V
K
N
L
---
V
G
Y
Y
I
I
M
E
G
I
F
F
Y
S
G
F
V
M
I
L
S
F
H
R
Q
N
K
M
I
G
I
G
E
Q
Y
Q
Y
I
L
R
D
E
T
I
H
L
N
F
G
I
D
L
I
N
G
I
K
E
E
--
N
P
E
I
--
W
T
P
E
L
Q
Q
E
I
V
E
L
I
K
R
A
V
D
L
E
I
E
Y
A
Q
D
C
L
P
R
G
--
I
L
G
L
R
A
S
M
F
I
D
Y
V
Q
H
I
A
D
R
R
L
E
R
I
G
L
-
K
P
I
Y
H
--
T
K
N
P
F
P
W
M
S
E
-----------------------------------------
4
PsiBlast_PDB
92.32
30%
-103
- C3 -
4M1H
-
RIR2_CHLTR
A:
[53-342]
--------------
P
I
K
Y
K
W
A
W
E
H
Y
L
N
G
C
A
N
N
W
L
P
T
E
I
P
M
G
K
D
I
E
L
W
K
S
D
R
-
L
S
E
D
E
R
R
V
I
L
L
N
L
G
F
F
S
T
A
E
S
L
V
G
N
N
I
V
L
A
I
F
K
H
V
T
N
P
-
E
A
R
Q
Y
L
L
R
Q
A
F
E
E
A
V
H
T
H
T
F
L
Y
I
C
E
S
-
L
G
L
D
-
E
---
K
----
E
I
--
F
--
N
A
Y
N
E
R
----
A
A
I
---
K
A
K
D
D
F
Q
M
E
I
TGKVLDPN
F
R
T
D
S
V
--------------------------
E
--
G
L
Q
E
F
V
K
N
L
---
V
G
Y
Y
I
I
M
E
G
I
F
F
Y
S
G
F
V
M
I
L
S
F
H
R
Q
N
K
M
I
G
I
G
E
Q
Y
Q
Y
I
L
R
D
E
T
I
H
L
N
F
G
I
D
L
I
N
G
I
K
E
E
--
N
P
E
I
--
W
T
P
E
L
Q
Q
E
I
V
E
L
I
K
R
A
V
D
L
E
I
E
Y
A
Q
D
C
L
P
R
G
--
I
L
G
L
R
A
S
M
F
I
D
Y
V
Q
H
I
A
D
R
R
L
E
R
I
G
L
-
K
P
I
Y
H
--
T
K
N
P
F
P
W
M
S
E
T
I
---------------------------------------
22
HHSearch
92.29
29%
-101
- C3 -
1SYY
3
RIR2_CHLTR
A:
[24-318]
--
N
Q
V
D
V
N
---
Q
L
V
P
I
K
Y
K
W
A
W
E
H
Y
L
N
G
C
A
N
N
W
L
P
T
E
I
P
M
G
K
D
I
E
L
W
K
S
-
D
R
L
S
E
D
E
R
R
V
I
L
L
N
L
G
F
F
S
T
A
E
S
L
V
-
G
N
N
I
V
L
A
I
F
K
H
V
T
N
P
E
A
R
Q
Y
L
L
R
Q
A
F
E
E
A
V
H
T
H
T
F
L
Y
I
C
E
S
-
L
G
L
D
-
E
K
--
E
----
I
---
F
--
N
A
Y
N
E
R
----
A
A
I
---
K
A
K
D
D
F
Q
M
E
---------
I
T
G
K
V
L
DPNFRTDS
V
-----------------
E
--
G
L
Q
E
F
V
K
N
L
---
V
G
Y
Y
I
I
M
E
G
I
F
F
Y
S
G
F
V
M
I
L
S
F
H
R
Q
N
K
M
I
G
I
G
E
Q
Y
Q
Y
I
L
R
D
E
T
I
H
L
N
F
G
I
D
L
I
N
G
I
K
E
E
--
N
P
E
I
--
W
T
P
E
L
Q
Q
E
I
V
E
L
I
K
R
A
V
D
L
E
I
E
Y
A
Q
D
C
L
P
-
R
G
-
I
L
G
L
R
A
S
M
F
I
D
Y
V
Q
H
I
A
D
R
R
L
E
R
I
G
L
-
K
P
I
Y
H
T
--
K
N
P
F
P
W
M
-------------------------------------------
1
PsiBlast_PDB
91.58
31%
-101
- C3 -
2ANI
3
RIR2_CHLTR
A:
[33-318]
--------------
P
I
K
Y
K
W
A
W
E
H
Y
L
N
G
C
A
N
N
W
L
P
T
E
I
P
M
G
K
D
I
E
L
W
K
S
D
R
-
L
S
E
D
E
R
R
V
I
L
L
N
L
G
F
F
S
T
A
E
S
L
V
G
N
N
I
V
L
A
I
F
K
H
V
T
N
P
-
E
A
R
Q
Y
L
L
R
Q
A
F
E
E
A
V
H
T
H
T
Y
L
Y
I
C
E
S
-
L
G
L
D
-
E
---
K
----
E
I
--
F
--
N
A
Y
N
E
R
----
A
A
I
---
K
A
K
D
D
F
Q
M
E
ITGKVLDPN
F
R
T
D
S
V
--------------------------
E
--
G
L
Q
E
F
V
K
N
L
---
V
G
Y
Y
I
I
M
E
G
I
F
F
Y
S
G
F
V
M
I
L
S
F
H
R
Q
N
K
M
I
G
I
G
E
Q
Y
Q
Y
I
L
R
D
E
T
I
H
L
N
F
G
I
D
L
I
N
G
I
K
E
E
--
N
P
E
I
--
W
T
P
E
L
Q
Q
E
I
V
E
L
I
K
R
A
V
D
L
E
I
E
Y
A
Q
D
C
L
P
R
G
--
I
L
G
L
R
A
S
M
F
I
D
Y
V
Q
H
I
A
D
R
R
L
E
R
I
G
L
-
K
P
I
Y
H
--
T
K
N
P
F
P
W
M
-------------------------------------------
3
PsiBlast_PDB
91.03
30%
-105
- C3 -
4D8G
2
RIR2_CHLTR
A:
[53-338]
--------------
P
I
K
Y
K
W
A
W
E
H
Y
L
N
G
C
A
N
N
W
L
P
T
E
I
P
M
G
K
D
I
E
L
W
K
S
D
R
-
L
S
E
D
E
R
R
V
I
L
L
N
L
G
F
F
S
T
A
E
S
L
V
G
N
N
I
V
L
A
I
F
K
H
V
T
N
P
-
E
A
R
Q
Y
L
L
R
Q
A
F
E
E
A
V
H
T
H
T
F
L
Y
I
C
E
S
-
L
G
L
D
-
E
---
K
----
E
I
--
F
--
N
A
Y
N
E
R
----
A
A
I
---
K
A
K
D
D
F
Q
M
E
I
T
GKVLDPN
F
R
T
D
S
V
--------------------------
E
--
G
L
Q
E
F
V
K
N
L
---
V
G
Y
Y
I
I
M
E
G
I
F
F
Y
S
G
F
V
M
I
L
S
F
H
R
Q
N
K
M
I
G
I
G
E
Q
Y
Q
Y
I
L
R
D
E
T
I
H
L
N
F
G
I
D
L
I
N
G
I
K
E
E
--
N
P
E
I
--
W
T
P
E
L
Q
Q
E
I
V
E
L
I
K
R
A
V
D
L
E
I
E
Y
A
Q
D
C
L
P
R
G
--
I
L
G
L
R
A
S
M
F
I
D
Y
V
Q
H
I
A
D
R
R
L
E
R
I
G
L
-
K
P
I
Y
H
--
T
K
N
P
F
P
W
M
-------------------------------------------
6
PsiBlast_PDB
90.21
30%
-102
- C3 -
1SYY
3
RIR2_CHLTR
A:
[33-318]
--------------
P
I
K
Y
K
W
A
W
E
H
Y
L
N
G
C
A
N
N
W
L
P
T
E
I
P
M
G
K
D
I
E
L
W
K
S
D
R
-
L
S
E
D
E
R
R
V
I
L
L
N
L
G
F
F
S
T
A
E
S
L
V
G
N
N
I
V
L
A
I
F
K
H
V
T
N
P
-
E
A
R
Q
Y
L
L
R
Q
A
F
E
E
A
V
H
T
H
T
F
L
Y
I
C
E
S
-
L
G
L
D
-
E
---
K
----
E
I
--
F
--
N
A
Y
N
E
R
----
A
A
I
---
K
A
K
D
D
F
Q
M
E
I
T
G
K
V
L
DPN
F
R
T
D
S
V
--------------------------
E
--
G
L
Q
E
F
V
K
N
L
---
V
G
Y
Y
I
I
M
E
G
I
F
F
Y
S
G
F
V
M
I
L
S
F
H
R
Q
N
K
M
I
G
I
G
E
Q
Y
Q
Y
I
L
R
D
E
T
I
H
L
N
F
G
I
D
L
I
N
G
I
K
E
E
--
N
P
E
I
--
W
T
P
E
L
Q
Q
E
I
V
E
L
I
K
R
A
V
D
L
E
I
E
Y
A
Q
D
C
L
P
R
G
--
I
L
G
L
R
A
S
M
F
I
D
Y
V
Q
H
I
A
D
R
R
L
E
R
I
G
L
-
K
P
I
Y
H
--
T
K
N
P
F
P
W
M
-------------------------------------------
9
PsiBlast_PDB
85.59
28%
-101
- C3 -
1H0N
2
RIR2_MOUSE
A:
[73-352]
--
L
L
R
E
N
P
RRF
V
V
F
P
I
E
Y
H
D
I
W
Q
M
Y
K
K
A
E
A
S
F
W
T
A
E
E
V
D
L
S
K
D
I
Q
H
W
E
--
A
-
L
K
P
D
E
R
H
F
I
S
H
V
L
A
F
F
A
A
S
D
G
I
V
-
N
E
N
L
V
E
R
F
S
Q
E
V
Q
V
T
E
A
R
C
F
Y
G
F
Q
I
A
M
E
N
I
H
S
E
M
Y
S
L
L
I
D
T
Y
I
K
D
P
K
E
---
R
----
E
---
Y
L
F
N
A
I
E
T
M
----
P
C
V
---
K
K
K
A
D
W
A
L
R
---------
W
----
I
--------------------------
G
--
D
K
E
A
T
Y
G
E
R
---
V
V
A
F
A
A
V
E
G
I
F
F
S
G
S
F
A
S
I
F
W
L
K
K
R
G
L
M
P
G
L
T
F
S
N
E
L
I
S
R
D
E
G
L
H
C
D
F
A
C
L
M
F
K
H
L
V
H
K
--
P
A
E
-----
Q
R
V
R
E
I
I
T
N
A
V
R
----
I
E
Q
E
F
L
T
E
A
L
P
V
K
L
-
I
-
G
M
N
C
T
L
M
K
Q
Y
I
E
F
V
A
D
R
L
M
L
E
L
G
F
-
N
K
I
F
R
V
--
E
N
P
F
D
F
M
E
------------------------------------------
14
PsiBlast_PDB
85.32
24%
-113
- C3 -
2RCC
6
RIR2_BACHD
A:
[38-313]
-----------------
F
S
W
A
Y
P
L
Y
K
N
M
L
A
N
F
W
T
P
F
E
I
N
M
S
H
D
A
K
Q
F
P
T
---
L
T
E
T
E
Q
E
A
F
K
K
I
I
G
L
L
A
F
L
D
-
S
V
-
Q
T
D
Y
S
M
R
A
A
E
Y
L
T
D
S
S
L
A
A
L
M
S
V
L
S
F
Q
E
V
V
H
N
Q
S
Y
S
Y
V
L
S
S
-
L
-
V
P
-
K
---
A
----
T
---
Q
--
D
E
I
F
E
Y
W
K
H
D
D
V
L
---
K
E
R
N
E
F
I
I
D
---------
G
Y
E
--
K
--------------------------
F
--
V
D
N
P
T
P
K
T
F
L
E
S
I
V
Y
D
V
I
L
E
G
L
N
F
Y
S
G
F
A
F
F
Y
N
L
A
R
N
Q
K
M
V
S
T
S
T
M
I
N
Y
I
N
R
D
E
Q
L
H
V
Y
L
F
T
N
I
F
K
E
L
L
V
E
--
F
P
E
L
--
N
T
E
E
T
K
T
F
V
K
T
T
L
M
K
A
A
D
L
E
K
D
W
F
R
--
Y
I
I
G
D
K
I
P
G
I
N
P
E
D
M
E
T
Y
I
S
F
I
A
N
K
R
A
V
Q
L
G
M
E
K
P
Y
P
E
I
-
K
H
N
P
M
K
W
I
-------------------------------------------
10
PsiBlast_PDB
85.24
28%
-99
- C3 -
1H0O
1
RIR2_MOUSE
A:
[73-352]
--
L
L
R
E
N
P
RRF
V
V
F
P
I
E
Y
H
D
I
W
Q
M
Y
K
K
A
E
A
S
F
W
T
A
E
E
V
D
L
S
K
D
I
Q
H
W
E
--
A
-
L
K
P
D
E
R
H
F
I
S
H
V
L
A
F
F
A
A
S
D
G
I
V
-
N
E
N
L
V
E
R
F
S
Q
E
V
Q
V
T
E
A
R
C
F
Y
G
F
Q
I
A
M
E
N
I
H
S
E
M
Y
S
L
L
I
D
T
Y
I
K
D
P
K
E
---
R
----
E
---
Y
L
F
N
A
I
E
T
M
----
P
C
V
---
K
K
K
A
D
W
A
L
R
---------
W
----
I
--------------------------
G
--
D
K
E
A
T
Y
G
E
R
---
V
V
A
F
A
A
V
E
G
I
F
F
S
G
S
F
A
S
I
F
W
L
K
K
R
G
L
M
P
G
L
T
F
S
N
E
L
I
S
R
D
E
G
L
H
C
D
F
A
C
L
M
F
K
H
L
V
H
K
--
P
A
E
-----
Q
R
V
R
E
I
I
T
N
A
V
R
----
I
E
Q
E
F
L
T
E
A
L
P
V
K
L
-
I
-
G
M
N
C
T
L
M
K
Q
Y
I
E
F
V
A
D
R
L
M
L
E
L
G
F
-
N
K
I
F
R
V
--
E
N
P
F
D
F
M
E
------------------------------------------
13
PsiBlast_PDB
84.41
28%
-100
- C3 -
1XSM
1
RIR2_MOUSE
A:
[73-352]
--
L
L
R
E
N
P
RRF
V
V
F
P
I
E
Y
H
D
I
W
Q
M
Y
K
K
A
E
A
S
F
W
T
A
E
E
V
D
L
S
K
D
I
Q
H
W
E
--
A
-
L
K
P
D
E
R
H
F
I
S
H
V
L
A
F
F
A
A
S
D
G
I
V
-
N
E
N
L
V
E
R
F
S
Q
E
V
Q
V
T
E
A
R
C
F
Y
G
F
Q
I
A
M
E
N
I
H
S
E
M
Y
S
L
L
I
D
T
Y
I
K
D
P
K
E
---
R
----
E
---
Y
L
F
N
A
I
E
T
M
----
P
C
V
---
K
K
K
A
D
W
A
L
R
---------
W
----
I
--------------------------
G
--
D
K
E
A
T
Y
G
E
R
---
V
V
A
F
A
A
V
E
G
I
F
F
S
G
S
F
A
S
I
F
W
L
K
K
R
G
L
M
P
G
L
T
F
S
N
E
L
I
S
R
D
E
G
L
H
C
D
F
A
C
L
M
F
K
H
L
V
H
K
--
P
A
E
-----
Q
R
V
R
E
I
I
T
N
A
V
R
----
I
E
Q
E
F
L
T
E
A
L
P
V
K
L
-
I
-
G
M
N
C
T
L
M
K
Q
Y
I
E
F
V
A
D
R
L
M
L
E
L
G
F
-
N
K
I
F
R
V
--
E
N
P
F
D
F
M
E
------------------------------------------
25
HHSearch
84.27
21%
-107
- C3 -
2RCC
6
RIR2_BACHD
A:
[26-313]
--
K
S
S
N
V
L
---
N
W
D
D
V
R
F
S
W
A
Y
P
L
Y
K
N
M
L
A
N
F
W
T
P
F
E
I
N
M
S
H
D
A
K
Q
F
P
T
---
L
T
E
T
E
Q
E
A
F
K
K
I
I
G
L
L
A
F
L
D
S
V
Q
--
T
D
Y
S
M
R
A
A
E
Y
L
T
D
S
S
L
A
A
L
M
S
V
L
S
F
Q
E
V
V
H
N
Q
S
Y
S
Y
V
L
S
S
-
L
V
P
K
-
A
T
Q
D
E
----
I
---
F
--
E
Y
W
K
H
D
----
D
V
L
---
K
E
R
N
E
F
I
I
D
---------
G
Y
E
K
F
V
--------------------------
D
NP
T
P
K
T
F
L
E
S
I
---
V
-
Y
D
V
I
L
E
G
L
N
F
Y
S
G
F
A
F
F
Y
N
L
A
R
N
Q
K
M
V
S
T
S
T
M
I
N
Y
I
N
R
D
E
Q
L
H
V
Y
L
F
T
N
I
F
K
E
L
L
V
E
--
F
P
E
L
--
N
T
E
E
T
K
T
F
V
K
T
T
L
M
K
A
A
D
L
E
K
D
W
F
R
Y
I
I
G
-
D
K
-
I
P
G
I
N
P
E
D
M
E
T
Y
I
S
F
I
A
N
K
R
A
V
Q
L
G
M
-
E
K
P
Y
P
E
I
K
H
N
P
M
K
W
I
-------------------------------------------
19
PsiBlast_PDB
84.15
24%
-100
- C3 -
3OLJ
1
RIR2_HUMAN
A:
[8-286]
--
L
L
R
E
N
P
RRF
V
I
F
P
I
E
Y
H
D
I
W
Q
M
Y
K
K
A
E
A
S
F
W
T
A
E
E
V
D
L
S
K
D
I
Q
H
W
E
--
S
-
L
K
P
E
E
R
Y
F
I
S
H
V
L
A
F
F
A
A
S
D
G
I
V
-
N
E
N
L
V
E
R
F
S
Q
E
V
Q
I
T
E
A
R
C
F
Y
G
F
Q
I
A
M
E
N
I
H
S
E
M
Y
S
L
L
I
D
T
Y
I
K
D
P
-
K
---
E
----
R
E
F
L
F
--
N
A
I
E
T
M
----
P
C
V
---
K
K
K
A
D
W
A
L
R
---------
W
----
I
--------------------------
G
--
D
K
E
A
T
Y
G
E
R
---
V
V
A
F
A
A
V
E
G
I
F
F
S
G
S
F
A
S
I
F
W
L
K
K
R
G
L
M
P
G
L
T
F
S
N
E
L
I
S
R
D
E
G
L
H
C
D
F
A
C
L
M
F
K
H
L
V
H
K
--
P
S
E
-----
E
R
V
R
E
I
I
I
N
A
V
R
----
I
E
Q
E
F
L
T
E
A
L
P
V
K
L
-
I
-
G
M
N
C
T
L
M
K
Q
Y
I
E
F
V
A
D
R
L
M
L
E
L
G
F
-
S
K
V
F
R
V
--
E
N
P
F
D
F
M
-------------------------------------------
11
PsiBlast_PDB
83.51
28%
-98
- C3 -
1W68
1
RIR2_MOUSE
A:
[73-348]
--
L
L
R
E
N
P
RRF
V
V
F
P
I
E
Y
H
D
I
W
Q
M
Y
K
K
A
E
A
S
F
W
T
A
E
E
V
D
L
S
K
D
I
Q
H
W
E
--
A
-
L
K
P
D
E
R
H
F
I
S
H
V
L
A
F
F
A
A
S
D
G
I
V
-
N
E
N
L
V
E
R
F
S
Q
E
V
Q
V
T
E
A
R
C
F
Y
G
F
Q
I
A
M
E
N
I
H
S
E
M
Y
S
L
L
I
D
T
Y
I
K
D
P
K
E
---
R
----
E
---
Y
L
F
N
A
I
E
T
M
----
P
C
V
---
K
K
K
A
D
W
A
L
R
---------
W
----
I
--------------------------
G
--
D
K
E
A
T
Y
G
E
R
---
V
V
A
F
A
A
V
E
G
I
F
F
S
G
S
F
A
S
I
F
W
L
K
K
R
G
L
M
P
G
L
T
F
S
N
E
L
I
S
R
D
E
G
L
H
C
D
F
A
C
L
M
F
K
H
L
V
H
K
--
P
A
E
-----
Q
R
V
R
E
I
I
T
N
A
V
R
----
I
E
Q
E
F
L
T
E
A
L
P
V
K
L
-
I
-
G
M
N
C
T
L
M
K
Q
Y
I
E
F
V
A
D
R
L
M
L
E
L
G
F
-
N
K
I
F
R
V
--
E
N
P
F
----------------------------------------------
12
PsiBlast_PDB
83.45
28%
-98
- C3 -
1W69
3
RIR2_MOUSE
A:
[73-348]
--
L
L
R
E
N
P
RRF
V
V
F
P
I
E
Y
H
D
I
W
Q
M
Y
K
K
A
E
A
S
F
W
T
A
E
E
V
D
L
S
K
D
I
Q
H
W
E
--
A
-
L
K
P
D
E
R
H
F
I
S
H
V
L
A
F
F
A
A
S
D
G
I
V
-
N
E
N
L
V
E
R
F
S
Q
E
V
Q
V
T
E
A
R
C
F
Y
G
F
Q
I
A
M
E
N
I
H
S
E
M
Y
S
L
L
I
D
T
Y
I
K
D
P
K
E
---
R
----
E
---
Y
L
F
N
A
I
E
T
M
----
P
C
V
---
K
K
K
A
D
W
A
L
R
---------
W
----
I
--------------------------
G
--
D
K
E
A
T
Y
G
E
R
---
V
V
A
F
A
A
V
E
G
I
F
F
S
G
S
F
A
S
I
F
W
L
K
K
R
G
L
M
P
G
L
T
F
S
N
E
L
I
S
R
D
E
G
L
H
C
D
F
A
C
L
M
F
K
H
L
V
H
K
--
P
A
E
-----
Q
R
V
R
E
I
I
T
N
A
V
R
----
I
E
Q
E
F
L
T
E
A
L
P
V
K
L
-
I
-
G
M
N
C
T
L
M
K
Q
Y
I
E
F
V
A
D
R
L
M
L
E
L
G
F
-
N
K
I
F
R
V
--
E
N
P
F
----------------------------------------------
20
PsiBlast_PDB
83.42
26%
-97
- C3 -
4DJN
-
RIR2B_HUMAN
A:
[35-303]
--------------
P
I
Q
Y
P
D
I
W
K
M
Y
K
Q
A
Q
A
S
F
W
T
A
E
E
V
D
L
S
K
D
L
P
H
W
N
--
K
-
L
K
A
D
E
K
Y
F
I
S
H
I
L
A
F
F
A
A
S
D
G
I
V
-
N
E
N
L
V
E
R
F
S
Q
E
V
Q
V
P
E
A
R
C
F
Y
G
F
Q
I
L
I
E
N
V
H
S
E
M
Y
S
L
L
I
D
T
Y
I
R
D
P
-
K
---
K
----
R
E
F
L
F
--
N
A
I
E
T
M
----
P
Y
V
---
K
K
K
A
D
W
A
L
R
---------
W
----
I
--------------------------
A
--
D
R
K
S
T
F
G
E
R
---
V
V
A
F
A
A
V
E
G
V
F
F
S
G
S
F
A
A
I
F
W
L
K
K
R
G
L
M
P
G
L
T
F
S
N
E
L
I
S
R
D
E
G
L
H
C
D
F
A
C
L
M
F
Q
Y
L
V
N
K
--
P
S
E
-----
E
R
V
R
E
I
I
V
D
A
----
V
K
I
E
Q
E
F
L
T
E
A
L
P
V
G
L
-
I
-
G
M
N
C
I
L
M
K
Q
Y
I
E
F
V
A
D
R
L
L
V
E
L
G
F
-
S
K
V
F
Q
A
--
E
N
P
F
D
F
M
E
N
-----------------------------------------
8
PsiBlast_PDB
82.77
26%
-96
- C3 -
2UW2
1
RIR2_HUMAN
A:
[15-293]
--
L
L
R
E
N
P
----
I
F
P
I
E
Y
H
D
I
W
Q
M
Y
K
K
A
E
A
S
F
W
T
A
E
E
V
D
L
S
K
D
I
Q
H
W
E
--
S
-
L
K
P
E
E
R
Y
F
I
S
H
V
L
A
F
F
A
A
S
D
G
I
V
-
N
E
N
L
V
E
R
F
S
Q
E
V
Q
I
T
E
A
R
C
F
Y
G
F
Q
I
A
M
E
N
I
H
S
E
M
Y
S
L
L
I
D
T
Y
I
K
D
P
-
K
---
E
----
R
EFL--------
M
----
P
C
V
---
K
K
K
A
D
W
A
L
R
---------
W
----
I
--------------------------
G
--
D
K
E
A
T
Y
G
E
R
---
V
V
A
F
A
A
V
E
G
I
F
F
S
G
S
F
A
S
I
F
W
L
K
K
R
G
P
M
P
G
L
T
F
S
N
E
L
I
S
R
D
E
G
L
H
C
D
F
A
C
L
M
F
K
H
L
V
H
K
--
P
S
E
-----
E
R
V
R
E
I
I
I
N
A
V
R
----
I
E
Q
E
F
L
T
E
A
L
P
V
K
L
-
I
-
G
M
N
C
T
L
M
K
Q
Y
I
E
F
V
A
D
R
L
M
L
E
L
G
F
-
S
K
V
F
R
V
--
E
N
P
F
D
F
M
-------------------------------------------
23
HHSearch
80.95
21%
-93
* C3 *
1MXR
7
RIR2_ECOLI
A:
[22-339]
---
P
V
N
V
A
---
R
Y
D
Q
Q
K
Y
D
I
F
E
K
L
I
E
K
Q
L
S
F
F
W
R
P
E
E
V
D
V
S
R
D
R
I
D
Y
Q
A
---
L
P
E
H
E
K
H
I
F
I
S
N
L
K
Y
Q
T
L
L
D
S
I
Q
-
G
R
S
P
N
V
A
L
L
P
L
I
S
I
P
E
L
E
T
W
V
E
T
W
A
F
S
E
T
I
H
S
R
S
Y
T
H
I
I
R
N
-
I
V
N
D
-
P
S
--
V
----
V
---
F
--
D
D
I
V
T
N
----
E
Q
I
---
Q
K
R
A
E
G
I
S
S
---------
Y
Y
D
E
L
I
E
M
T
S
Y
W
H
L
LGE
G
T
H
T
V
NG
K
T
V
T
V
S
L
R
E
--
L
K
K
K
L
Y
L
C
L
---
M
-
S
V
N
A
L
E
A
I
R
F
Y
V
S
F
A
C
S
F
A
F
A
E
R
E
L
M
E
G
N
A
K
I
I
R
L
I
A
R
D
E
A
L
H
L
T
G
T
Q
H
M
L
N
L
L
R
S
G
AD
D
P
E
M
A
E
I
A
E
E
C
K
Q
E
C
Y
D
L
F
V
Q
A
A
Q
Q
E
K
D
W
A
D
Y
L
F
R
D
G
S
-
M
I
G
L
N
K
D
I
L
C
Q
Y
V
E
Y
I
T
N
I
R
M
Q
A
V
G
L
-
D
L
P
F
Q
T
-
R
S
N
P
I
P
W
I
N
T
W
L
---------------------------------------
24
HHSearch
80.73
25%
-94
- C3 -
1H0O
1
RIR2_MOUSE
A:
[77-352]
---
N
P
R
R
F
---
V
V
F
P
I
E
Y
H
D
I
W
Q
M
Y
K
K
A
E
A
S
F
W
T
A
E
E
V
D
L
S
K
D
I
Q
H
W
E
A
---
L
K
P
D
E
R
H
F
I
S
H
V
L
A
F
F
A
A
S
D
G
I
V
-
N
E
N
L
V
E
R
F
S
Q
E
V
Q
V
T
E
A
R
C
F
Y
G
F
Q
I
A
M
E
N
I
H
S
E
M
Y
S
L
L
I
D
T
-
Y
I
K
D
-
P
---
K
E
R
E
Y
L
---
F
--
N
A
I
E
T
M
----
P
C
V
---
K
K
K
A
D
W
A
L
R
---------
W
I
G
D
K
-------------------------------
E
A
T
Y
G
E
R
V
---
V
-
A
F
A
A
V
E
G
I
F
F
S
G
S
F
A
S
I
F
W
L
K
K
R
G
L
M
P
G
L
T
F
S
N
E
L
I
S
R
D
E
G
L
H
C
D
F
A
C
L
M
F
K
H
L
V
H
K
---
P
--------
A
E
Q
R
V
R
E
I
I
T
N
A
V
R
I
E
Q
E
F
L
T
E
A
L
P
-
V
K
-
L
I
G
M
N
C
T
L
M
K
Q
Y
I
E
F
V
A
D
R
L
M
L
E
L
G
F
-
N
K
I
F
R
V
--
E
N
P
F
D
F
M
E
------------------------------------------
17
PsiBlast_PDB
80.61
26%
-98
- C3 -
2VUX
1
RIR2B_HUMAN
A:
[50-316]
--------------
P
I
Q
Y
P
D
I
W
K
M
Y
K
Q
A
Q
A
S
F
W
T
A
E
E
V
D
L
S
K
D
L
P
H
W
N
--
K
-
L
K
A
D
E
K
Y
F
I
S
H
I
L
A
F
F
A
A
S
-------
N
L
V
E
R
F
S
Q
E
V
Q
V
P
E
A
R
C
F
Y
G
F
Q
I
L
I
E
N
V
H
S
E
M
Y
S
L
L
I
D
T
Y
I
R
D
P
-
K
---
K
----
R
---
E
--
F
L
F
N
A
I
----
E
T
M
P
Y
V
K
K
K
A
D
W
A
L
R
---------
W
----
I
--------------------------
A
--
D
R
K
S
T
F
G
E
R
---
V
V
A
F
A
A
V
E
G
V
F
F
S
G
S
F
A
A
I
F
W
L
K
K
R
G
L
M
P
G
L
T
F
S
N
E
L
I
S
R
D
E
G
L
H
C
D
F
A
C
L
M
F
Q
Y
L
V
N
K
--
P
S
E
-----
E
R
V
R
E
I
I
V
D
A
----
V
K
I
E
Q
E
F
L
T
E
A
L
P
V
G
L
-
I
-
G
M
N
C
I
L
M
K
Q
Y
I
E
F
V
A
D
R
L
L
V
E
L
G
F
-
S
K
V
F
Q
--
A
E
N
P
F
D
F
M
-------------------------------------------