@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0296: (2015-11-30 )
MEYEQWKEILSAIDKETDLSKDNVIAKIKEKLKALDSSTYEEWKETNFDVNHLFAVKYGLLHLAVHNNLKNVVNALFGVEGIDVNAVDKDKHTSLHLAVEKGHIGIVNSLLEVKADVNVEDENGKTPLYTAVQFGCKGEIEVLIGKMMIGALIRAGANVNAEDKDKCTPLHFAARCGRKEIVQTLIEAGANVNAANEDKRTPSHIATQFCRKEIVKVLVEAGADVRAADKYGITPLHFADGAETVKTLIGAGANVNVVDKDKRTPLHWVKGAETAETLIEAGVNVNTIDKGKRNPLHMAARCSCEGVIKTLIGKRADLLSKNNDSKIPSNFNKSHYIIRRVKSLWSEERMKRLDQQSKVSFVVFGLTILFGTATATTLFVTETIAFGPYPIIGTVVIVAAAAWVVSCAADKILEPSTKIDEMKAVQVDENMQKAPLNLST
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........---80.......-.90........100.......110...----....120.......130.......140.......150....----...160-.-......170.......180.....---------------------..190....----------...-200.......210-.........220--------------------.---.......230.......---240------........250....--------...-260.....---..270--.---.---......-280-........290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
E
Y
E
Q
W
K
E
I
L
S
A
IDKETDLSK
D
N
V
I
A
K
I
K
E
K
L
K
ALD
S
S
T
Y
E
E
W
K
ETNFD
V
N
H
L
F
A
V
K
Y
G
L
L
H
L
A
V
HN
N
L
K
N
V
V
N
A
L
FGV---EG
I
D
VNAVD-KDKH
T
S
L
H
L
A
V
EKG
H
I
G
I
V
N
S
L
L
EVKA----D
V
N
V
EDENGKT
P
L
Y
T
A
V
QFGCKG
E
I
E
V
L
I
G
K
M
M
I
G
A
L
I
RAG----ANVNAE-D-KDKCT
P
L
H
F
A
A
RC
G
R
K
E
I
V
Q
T
L
I
E---------------------AGANVNAAN----------EDK-R
T
P
S
H
I
A
T
Q
F
C
---
R
K
E
I
V
K
V
L
V
EA---------------------G---ADVRAADKYGI
T
P
L
HFA---D
G
-------
A
E
T
V
K
T
L
IGAGAN
V
N
--------
V
VD-KDKRTP
L
H
---
W
VKG---A---
E
---
T
A
E
T
L
I
-
E
-A-GVNVNTIDKGKRNPL
H
M
AARC
S
C
E
G
V
I
K
T
L
I
G
K
R
A
D
L
LSKNNDSKIPSNFN
K
S
H
Y
I
I
R
R
V
K
S
L
W
S
E
E
R
M
K
R
L
D
Q
Q
SK
V
S
F
V
V
F
G
L
T
I
L
FGTA
T
A
T
T
L
F
V
T
E
TIAFGPY
P
I
I
G
T
V
V
I
V
A
A
A
A
W
V
V
S
C
A
ADKILEPSTKID
E
M
K
A
V
QVDENMQKAPLNLST
106
HHSearch
89.58
28%
-55
- C4 -
1N11
9
A:
[68-393]
--------------------------------------------
Q
N
K
A
K
V
N
A
K
A
K
D
D
Q
T
P
L
H
C
A
A
R
I
G
H
T
N
M
V
K
L
L
L
-
E
---
N
N
A
N
P
N
L
A
T
-
T
A
G
H
T
P
L
H
I
A
A
R
E
G
H
V
E
T
V
L
A
L
L
E
K
E
A
----
S
Q
A
C
M
T
K
K
G
F
T
P
L
H
V
A
A
K
Y
G
K
V
R
V
A
E
L
L
---------
L
E
R
D
----
A
H
P
N
A
A
-
G
-
K
N
G
L
T
P
L
H
V
A
V
H
H
N
N
L
D
I
V
K
L
L
L
P
---------------------
R
G
G
S
P
H
S
P
A
----------
W
N
G
-
Y
T
P
L
H
I
A
A
K
Q
N
---
Q
V
E
V
A
R
S
L
L
Q
Y
---------------------
G
---
G
S
A
N
A
E
S
V
Q
G
V
T
P
L
H
L
A
A
Q
E
G
H
-------
A
E
M
V
A
L
L
L
S
K
Q
A
N
G
N
--------
L
G
N
-
K
S
G
L
T
P
L
H
---
L
V
A
Q
---
E
GH
V
P
---
V
A
D
V
L
I
-
K
-
H
-
G
V
M
V
D
A
T
T
R
M
G
Y
T
P
L
H
V
A
S
H
Y
G
N
I
K
L
V
K
F
L
L
Q
H
Q
A
D
V
N
A
K
T
K
L
G
Y
S
P
L
H
Q
A
A
Q
Q
G
H
T
D
I
V
T
L
L
L
K
N
--
G
A
S
P
N
E
V
S
S
D
G
T
T
P
L
A
I
A
K
R
L
G
Y
I
S
V
T
D
V
L
K
V
V
T
D
E
T
S
F
V
L
H
R
M
S
F
P
E
T
V
D
E
---------------------------------------
107
HHSearch
87.44
28%
-59
- C4 -
1N11
9
A:
[40-364]
-------------------------------------------------
P
N
V
S
N
V
K
V
E
T
P
L
H
M
A
A
R
A
G
H
T
E
V
A
K
Y
L
L
-
Q
---
N
K
A
K
V
N
A
K
A
-
K
D
D
Q
T
P
L
H
C
A
A
R
I
G
H
T
N
M
V
K
L
L
L
E
N
N
A
----
N
P
N
L
A
T
T
A
G
H
T
P
L
H
I
A
A
R
E
G
H
V
E
T
V
L
A
L
---------
L
E
K
E
----
A
S
Q
A
C
M
-
T
-
K
K
G
F
T
P
L
H
V
A
A
K
Y
G
K
V
R
V
A
E
L
L
L
E
---------------------
R
D
A
H
P
N
A
A
G
----------
K
N
G
-
L
T
P
L
H
V
A
V
H
H
N
---
N
L
D
I
V
K
L
L
L
P
R
---------------------
G
---
G
S
P
H
S
P
A
W
N
G
Y
T
P
L
H
I
A
A
K
Q
N
Q
-------
V
E
V
A
R
S
L
L
Q
Y
G
G
S
A
N
--------
A
E
S
-
V
Q
G
V
T
P
L
H
---
L
A
A
Q
---
E
---
G
H
A
E
M
V
A
L
L
L
-
S
-
K
-
Q
A
N
G
N
L
G
N
K
S
G
L
T
P
L
H
L
V
A
Q
E
G
H
V
P
V
A
D
V
L
I
K
H
G
V
M
V
D
A
T
T
R
M
G
Y
T
P
L
H
V
A
S
H
Y
G
N
I
K
L
V
K
F
L
L
Q
H
--
Q
A
D
V
N
A
K
T
K
L
G
Y
S
P
L
H
Q
A
A
Q
Q
G
H
T
D
I
V
T
L
L
L
K
N
G
A
S
P
N
E
V
S
S
D
G
T
T
P
L
A
I
A
K
R
L
G
Y
I
S
V
T
D
V
L
K
V
V
T
D
E
T
S
F
V
L
H
R
M
S
F
P
E
T
V
D
E
------
14
PsiBlast_PDB
81.09
32%
-60
- C4 -
1N11
7
A:
[114-340]
-----------------------------------------------------------------------------------------------
H
T
P
L
H
I
A
A
R
E
G
H
V
E
T
V
L
A
L
L
E
K
E
A
----
S
Q
A
C
M
T
K
K
G
F
T
P
L
H
V
A
A
K
Y
G
-----
K
V
R
V
A
E
L
----
L
L
E
R
D
----
A
H
P
N
A
A
-
G
-
K
N
G
L
T
P
L
H
V
A
V
H
H
N
N
L
D
I
V
K
L
L
L
P
---------------------
R
G
G
S
P
H
S
P
A
----------
W
N
G
-
Y
T
P
L
H
I
A
A
K
Q
N
---
Q
V
E
V
A
R
S
L
L
Q
Y
---------------------
G
---
G
S
A
N
A
E
S
V
Q
G
V
T
P
L
H
L
A
A
Q
E
G
H
-------
A
E
M
V
A
L
L
L
S
K
Q
A
N
G
N
--------
L
G
N
-
K
S
G
L
T
P
L
H
---
L
V
A
Q
E
GH
V
---
P
---
V
A
D
V
L
I
-
K
-
H
-
G
V
M
V
D
A
T
T
R
M
G
Y
T
P
L
H
V
A
S
H
Y
G
N
I
K
L
V
K
F
L
L
Q
H
Q
A
D
V
N
A
K
T
K
L
G
Y
S
P
L
H
Q
A
A
Q
Q
G
H
T
D
I
V
T
L
L
L
K
N
G
A
S
P
N
E
V
S
S
D
G
T
T
P
L
A
I
A
K
R
L
G
Y
I
S
V
T
D
V
L
K
V
V
T
D
E
T
S
F
V
L
H
R
M
S
F
P
E
T
V
D
E
-----------------------------------------
8
PsiBlast_PDB
80.99
32%
-73
- C4 -
4RLV
4
ANK2_HUMAN
A:
[439-691]
------------------------------------------------------------
L
H
I
A
C
K
K
N
R
I
K
V
M
E
L
L
V
K
Y
----
G
A
S
I
Q
A
I
T
-
E
S
G
L
T
P
I
H
V
A
A
F
M
G
H
L
N
I
V
L
L
L
L
Q
N
G
A
----
S
P
D
V
T
N
I
R
G
E
T
A
L
H
M
A
A
R
---
A
G
Q
V
E
V
------
V
R
C
L
L
R
N
G
----
A
L
V
D
A
R
-
A
-
R
E
E
Q
T
P
L
H
I
A
S
R
L
G
K
T
E
I
V
Q
L
L
L
Q
---------------------
H
M
A
H
P
D
A
A
T
----------
T
N
G
-
Y
T
P
L
H
I
S
A
R
E
G
---
Q
V
D
V
A
S
V
L
L
E
A
---------------------
G
---
A
A
H
S
L
A
T
K
K
G
F
T
P
L
H
V
A
A
K
Y
G
S
-------
L
D
V
A
K
L
L
L
Q
R
R
A
A
A
D
--------
S
A
G
-
K
N
G
L
T
P
L
H
V
A
A
H
Y
D
N
---
Q
---
K
---
V
A
L
L
L
L
-
E
-
K
-
G
A
S
P
H
A
T
A
K
N
G
Y
T
P
L
H
I
A
A
K
K
N
Q
M
Q
I
A
S
T
L
L
N
Y
G
A
E
T
N
I
V
T
K
Q
G
V
T
P
L
H
L
A
S
Q
E
G
H
T
D
M
V
T
L
L
L
D
K
G
A
N
I
H
M
S
T
K
S
G
L
T
S
L
H
L
A
A
Q
E
D
K
V
N
V
A
D
I
L
T
K
H
G
A
D
Q
D
A
H
T
K
L
G
Y
T
P
L
I
V
A
C
H
Y
G
N
V
K
M
V
N
F
L
L
K
Q
G
A
N
V
N
A
K
T
K
N
G
Y
T
P
L
H
Q
A
A
Q
Q
G
H
T
H
I
I
108
HHSearch
80.77
29%
-59
- C4 -
1WDY
1
RN5A_HUMAN
A:
[5-283]
--------------------------------------------------------
D
N
H
L
L
I
K
A
V
Q
N
E
D
V
D
L
V
Q
Q
L
L
-
E
---
G
G
A
N
V
N
F
Q
E
E
E
G
G
W
T
P
L
H
N
A
V
Q
M
S
R
E
D
I
V
E
L
L
L
R
H
G
A
----
D
P
V
L
R
K
K
N
G
A
T
P
F
L
L
A
A
I
A
G
S
V
K
L
L
K
L
F
---------
L
S
K
G
----
A
D
V
N
E
C
-
D
-
F
Y
G
F
T
A
F
M
E
A
A
V
Y
G
K
V
K
A
L
K
F
L
Y
K
---------------------
R
G
A
N
V
N
L
R
R
KTK
E
D
Q
E
R
L
R
K
G
G
-
A
T
A
L
M
D
A
A
E
K
G
---
H
V
E
V
L
K
I
L
L
D
E
M--------------------
G
---
A
D
V
N
A
C
D
N
M
G
R
N
A
L
I
H
A
---
L
L
SSDDSD
V
E
A
I
T
H
L
L
L
D
H
G
A
D
V
N
--------
V
R
G
-
E
R
G
K
T
P
L
I
---
L
A
V
E
---
K
---
K
H
L
G
L
V
Q
R
L
L
-
E
-
Q
E
H
I
E
I
N
D
T
D
S
D
G
K
T
A
L
L
L
A
V
E
L
K
L
K
K
I
A
E
L
L
C
K
R
G
A
S
T
D
C
G
D
L
V
--------------------------------------------------------------------------------------------------------------------
109
HHSearch
79.15
28%
-58
* C5 *
3UTM
-
TNKS1_MOUSE
A:
[324-623]
----------------------------------------------------
T
G
E
Y
K
K
D
E
L
L
E
A
A
R
S
G
N
E
E
K
L
M
A
L
L
T
P
---
L
N
V
N
C
H
A
S
D
-
G
R
K
S
T
P
L
H
L
A
A
G
Y
N
R
V
R
I
V
Q
L
L
L
Q
H
G
A
----
D
V
H
A
K
D
K
G
G
L
V
P
L
H
N
A
C
S
Y
G
H
Y
E
V
T
E
L
L
---------
L
K
H
G
----
A
C
V
N
A
M
-
D
-
L
W
Q
F
T
P
L
H
E
A
A
S
K
N
R
V
E
V
C
S
L
L
L
S
---------------------
H
G
A
D
P
T
L
V
N
----------
C
H
G
-
K
S
A
V
D
M
A
P
T
P
E
---
L
R
E
R
L
T
Y
E
F
K
G
H
S
L
L
Q
A
A
R
E
AD
L
A
K
V
K
K
T
L
AL
E
---
I
I
N
F
K
Q
P
Q
S
H
E
T
A
L
H
C
A
---
V
A
SLHPK
R
-
K
Q
V
A
E
L
L
L
R
K
G
A
N
V
N
--------
E
K
N
-
K
D
F
M
T
P
L
H
---
V
A
A
E
---
R
---
A
H
N
D
V
M
E
V
L
H
-
K
-
H
-
G
A
K
M
N
A
L
D
S
L
G
Q
T
A
L
H
R
A
A
L
A
G
H
L
Q
T
C
R
L
L
L
S
Y
G
S
D
P
S
I
I
S
L
Q
G
F
T
A
A
Q
M
-------------------------------------------------------------------------------------------------------------
94
Fugue
75.66
26%
-59
- C4 -
1K1A
-
BCL3_HUMAN
A:
[125-352]
------------------------------------------------------
E
D
G
D
T
P
L
H
I
A
V
V
Q
G
N
L
P
A
V
H
R
L
V
N
L
F
Q
Q
G
G
R
E
L
D
I
Y
N
-
N
L
R
Q
T
P
L
H
L
A
V
I
T
T
L
P
S
V
V
R
L
L
V
T
A
G
A
----
S
P
M
A
L
D
R
H
G
Q
T
A
A
H
L
A
C
E
H
R
S
P
T
C
L
R
A
L
L
D
S
A
A
-----
P
G
T
----
L
D
L
E
A
R
-
N
-
Y
D
G
L
T
A
L
H
V
A
V
N
T
E
C
Q
E
T
V
Q
L
L
L
E
---------------------
R
G
A
D
I
D
A
V
D
----------
I
K
S
G
R
S
P
L
I
H
A
V
E
N
N
---
S
L
S
M
V
Q
L
L
L
Q
H
---------------------
G
---
A
N
V
N
A
Q
M
Y
S
G
S
S
A
L
H
S
A
---
S
G
R
GL----
L
P
L
V
R
T
L
V
R
S
G
A
D
S
S
--------
L
K
N
-
C
H
N
D
T
P
L
M
---
V
A
R
S
---
R
---
R
---
V
I
D
I
L
R
-
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
75.52
36%
-61
- C4 -
2DVW
-
PSD10_MOUSE
A:
[37-215]
------------------------------------------------------------------------------------------
D
-
Q
D
S
R
T
A
L
H
W
A
C
S
A
G
H
T
E
I
V
E
F
L
L
Q
L
G
V
----
P
V
N
D
K
D
D
A
G
W
S
P
L
H
I
A
A
S
A
G
-
R
D
E
I
--------
V
K
A
L
L
V
K
G
----
A
H
V
N
A
V
-
N
-
Q
N
G
C
T
P
L
H
Y
A
A
S
K
N
R
H
E
I
A
V
M
L
L
E
---------------------
G
G
A
N
P
D
A
K
D
----------
H
Y
D
-
A
T
A
M
H
R
A
A
A
K
G
---
N
L
K
M
V
H
I
L
L
F
Y
---------------------
K
---
A
S
T
N
I
Q
D
T
E
G
N
T
P
L
H
L
A
C
D
E
E
R
-------
V
E
E
A
K
F
L
V
T
Q
G
A
S
I
Y
--------
I
E
N
-
K
E
E
K
T
P
L
Q
---
V
A
K
G
---
G
---
L
---
G
L
I
L
K
R
-
L
-
A
-
E
G
E
E
A
S
M
--------------------------------------------------------------------------------------------------------------------------------------------------------
114
HHSearch
74.51
29%
-65
- C4 -
3D9H
-
ASB9_HUMAN
A:
[35-253]
-------------------------------------------------------
S
D
W
S
P
M
H
E
A
A
I
H
G
H
Q
L
S
L
R
N
L
I
-
S
---
Q
G
W
A
V
N
I
I
T
-
A
D
H
V
S
P
L
H
E
A
C
L
G
G
H
L
S
C
V
K
I
L
L
K
H
G
A
----
Q
V
N
G
V
T
A
D
W
H
T
P
L
F
N
A
C
V
S
G
S
W
D
C
V
N
L
L
---------
L
Q
H
G
----
A
S
V
Q
-
P
-
E
-
S
D
L
A
S
P
I
H
E
A
A
R
R
G
H
V
E
C
V
N
S
L
I
A
---------------------
Y
G
G
N
I
D
H
K
I
----------
S
H
L
-
G
T
P
L
Y
L
A
C
E
N
Q
---
Q
R
A
C
V
K
K
L
L
E
S
---------------------
G
---
A
D
V
N
Q
-
G
K
G
Q
D
S
P
L
H
A
V
V
R
T
A
S
-------
E
E
L
A
C
L
L
M
D
F
G
A
D
T
Q
--------
A
K
N
-
A
E
G
K
R
P
V
E
---
L
V
P
P
---
E
---
S
P
--
L
A
Q
L
F
L
E
R
-
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------
119
HHSearch
74.07
25%
-60
- C4 -
1K1A
-
BCL3_HUMAN
A:
[125-352]
------------------------------------------------------
E
D
G
D
T
P
L
H
I
A
V
V
Q
G
N
L
P
A
V
H
R
L
V
N
L
F
Q
Q
G
G
R
E
L
D
I
Y
N
-
N
L
R
Q
T
P
L
H
L
A
V
I
T
T
L
P
S
V
V
R
L
L
V
T
A
G
A
----
S
P
M
A
L
D
R
H
G
Q
T
A
A
H
L
A
C
E
H
R
S
P
T
C
L
R
A
L
---------
L
D
S
A
APGT
L
D
L
E
A
R
-
N
-
Y
D
G
L
T
A
L
H
V
A
V
N
T
E
C
Q
E
T
V
Q
L
L
L
E
---------------------
R
G
A
D
I
D
A
V
D
I---------
K
S
G
-
R
S
P
L
I
H
A
V
E
N
N
---
S
L
S
M
V
Q
L
L
L
Q
H
---------------------
G
---
A
N
V
N
A
Q
M
Y
S
G
S
S
A
L
H
S
A
----------------------------------------------------
S
G
---
R
GL
L
P
---
L
V
R
T
L
V
-
R
-
S
-
G
A
D
S
S
L
K
N
C
H
N
D
T
P
L
M
V
A
R
S
R
R
V
I
D
I
L
R
G
----------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
74.03
35%
-66
- C4 -
3AJI
-
PSD10_MOUSE
A:
[37-215]
------------------------------------------------------------------------------------------
D
-
Q
D
S
R
T
A
L
H
W
A
C
S
A
G
H
T
E
I
V
E
F
L
L
Q
L
G
V
----
P
V
N
D
K
D
D
A
G
W
S
P
L
H
I
A
A
S
A
G
----------
D
E
I
V
K
A
L
L
V
K
G
----
A
H
V
N
A
V
-
N
-
Q
N
G
C
T
P
L
H
Y
A
A
S
K
N
R
H
E
I
A
V
M
L
L
E
---------------------
G
G
A
N
P
D
A
K
D
----------
H
Y
D
-
A
T
A
M
H
R
A
A
A
K
G
---
N
L
K
M
V
H
I
L
L
F
Y
---------------------
K
---
A
S
T
N
I
Q
D
T
E
G
N
T
P
L
H
L
A
C
D
E
E
R
-------
V
E
E
A
K
F
L
V
T
Q
G
A
S
I
Y
--------
I
E
N
-
K
E
E
K
T
P
L
Q
---
V
A
K
G
---
G
---
L
---
G
L
I
L
K
R
-
L
-
A
-
E
G
E
E
A
S
M
--------------------------------------------------------------------------------------------------------------------------------------------------------
120
HHSearch
73.58
25%
-55
- C5 -
3UTM
-
TNKS1_MOUSE
A:
[358-635]
----------------------------------------------------
S
D
G
R
K
S
T
P
L
H
L
A
A
G
Y
N
R
V
R
I
V
Q
L
L
L
-
Q
---
H
G
A
D
V
H
A
K
D
-
K
G
G
L
V
P
L
H
N
A
C
S
Y
G
H
Y
E
V
T
E
L
L
L
K
H
G
A
----
C
V
N
A
M
D
L
W
Q
F
T
P
L
H
E
A
A
S
K
N
R
V
E
V
C
S
L
L
---------
L
S
H
G
----
A
D
P
T
L
V
-
N
-
C
H
G
K
S
A
V
D
M
A
P
T
P
E
L
R
E
R
L
T
Y
E
F
K
G
H
S
L
L
Q
A
A
R
E
AD
L
A
K
V
K
K
T
L
A
L
E
I
I
N
F
K
Q
P
----------
Q
S
H
-
E
T
A
L
H
C
A
V
A
S
L
HPK
R
K
Q
V
A
E
L
L
L
R
K
---------------------
G
---
A
N
V
N
E
K
N
K
D
F
M
T
P
L
H
V
A
A
E
R
A
H
-------
N
D
V
M
E
V
L
H
K
H
G
A
K
M
N
--------
A
L
D
-
S
L
G
Q
T
A
L
H
---
R
A
A
L
---
A
---
G
H
L
Q
T
C
R
L
L
L
-
S
-
Y
-
G
S
D
P
S
I
I
S
L
Q
G
F
T
A
A
Q
M
----
G
N
E
A
V
Q
Q
I
L
S
E
S
------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
73.15
36%
-59
- C4 -
2DWZ
1
PSD10_MOUSE
A:
[37-215]
------------------------------------------------------------------------------------------
D
-
Q
D
S
R
T
A
L
H
W
A
C
S
A
G
H
T
E
I
V
E
F
L
L
Q
L
G
V
----
P
V
N
D
K
D
D
A
G
W
S
P
L
H
I
A
A
S
A
G
-
R
D
E
I
--------
V
K
A
L
L
V
K
G
----
A
H
V
N
A
V
-
N
-
Q
N
G
C
T
P
L
H
Y
A
A
S
K
N
R
H
E
I
A
V
M
L
L
E
---------------------
G
G
A
N
P
D
A
K
D
----------
H
Y
D
-
A
T
A
M
H
R
A
A
A
K
G
---
N
L
K
M
V
H
I
L
L
F
Y
---------------------
K
---
A
S
T
N
I
Q
D
T
E
G
N
T
P
L
H
L
A
C
D
E
E
R
-------
V
E
E
A
K
F
L
V
T
Q
G
A
S
I
Y
--------
I
E
N
-
K
E
E
K
T
P
L
Q
---
V
A
K
G
---
G
---
L
---
G
L
I
L
K
R
-
L
-
A
-
E
G
E
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------
122
HHSearch
72.93
28%
-53
- C4 -
3EU9
3
ZDH17_HUMAN
A:
[8-233]
---------------------------------------------------------------------------------------------
Y
S
T
W
D
I
V
K
A
T
Q
Y
G
I
Y
E
R
C
R
E
L
V
E
A
G
Y
----
D
V
R
Q
P
D
K
E
N
V
T
L
L
H
W
A
A
I
N
N
R
I
D
L
V
K
Y
Y
---------
I
S
K
G
----
A
I
V
D
Q
L
G
G
-
D
L
N
S
T
P
L
H
W
A
T
R
Q
G
H
L
S
M
V
V
Q
L
M
K
---------------------
Y
G
A
D
P
S
L
I
D
----------
G
E
G
-
C
S
C
I
H
L
A
A
Q
F
G
---
H
T
S
I
V
A
Y
L
I
A
K
---------------------
G
---
Q
D
V
D
M
M
D
Q
N
G
M
T
P
L
M
W
A
---
A
Y
RTHS---
V
D
P
T
R
L
L
L
T
F
N
V
S
V
N
--------
L
G
D
K
Y
H
K
N
T
A
L
H
---
W
A
V
L
---
A
---
G
N
T
T
V
I
S
L
L
L
-
E
-
A
-
G
A
N
V
D
A
Q
N
I
K
G
E
S
A
L
D
L
A
K
Q
R
K
N
V
W
M
I
N
H
L
Q
E
A
R
-----------------------------------------------------------------------------------------------------------------------------
124
HHSearch
72.85
31%
-63
- C4 -
1K1A
-
BCL3_HUMAN
A:
[156-345]
------------------------------------------------
E
L
D
I
Y
N
N
L
R
Q
T
P
L
H
L
A
V
I
T
T
L
P
S
V
V
R
L
L
V
-
T
---
A
G
A
S
P
M
A
L
D
-
R
H
G
Q
T
A
A
H
L
A
C
E
H
R
S
P
T
C
L
R
A
L
L
D
S
A
A
PGTL
D
L
E
A
R
N
Y
D
G
L
T
A
L
H
V
A
V
N
T
E
C
Q
E
T
V
Q
L
L
---------
L
E
R
G
----
A
D
I
D
A
V
-
D
I
K
S
G
R
S
P
L
I
H
A
V
E
N
N
S
L
S
M
V
Q
L
L
L
Q
---------------------
H
G
A
N
V
N
A
Q
M
----------
Y
S
G
-
S
S
A
L
H
S
A
S
G
R
G
---
L
L
P
L
V
R
T
L
V
R
S
---------------------
G
---
A
D
S
S
L
K
N
C
H
N
D
T
P
L
M
V
A
---
R
S
-------
R
R
V
I
D
I
L
R
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
72.53
35%
-62
- C4 -
4NIK
-
PSD10_HUMAN
A:
[40-219]
-----------------------------------------------------------------------------------------
T
D
-
Q
D
S
R
T
A
L
H
W
A
C
S
A
G
H
T
E
I
V
E
F
L
L
Q
L
G
V
----
P
V
N
D
K
D
D
A
G
W
S
P
L
H
I
A
A
S
A
G
R
D
E
I
V
K
A
L
L
G
K
---------
G
----
A
Q
V
N
A
V
-
N
-
Q
N
G
C
T
P
L
H
Y
A
A
S
K
N
R
H
E
I
A
V
M
L
L
E
---------------------
G
G
A
N
P
D
A
K
D
----------
H
Y
E
-
A
T
A
M
H
R
A
A
A
K
G
---
N
L
K
M
I
H
I
L
L
Y
Y
---------------------
K
---
A
S
T
N
I
Q
D
T
E
G
N
T
P
L
H
L
A
C
D
E
E
R
-------
V
E
E
A
K
L
L
V
S
Q
G
A
S
I
Y
--------
I
E
N
-
K
E
E
K
T
P
L
Q
---
V
A
K
G
---
G
---
L
---
G
L
I
L
K
R
-
M
-
V
-
E
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
72.47
35%
-58
- C4 -
1QYM
-
PSD10_HUMAN
A:
[36-215]
-----------------------------------------------------------------------------------------
T
D
-
Q
D
S
R
T
A
L
H
W
A
C
S
A
G
H
T
E
I
V
E
F
L
L
Q
L
G
V
----
P
V
N
D
K
D
D
A
G
W
S
P
L
H
I
A
A
S
A
G
R
D
E
I
V
K
A
L
L
G
K
---------
G
----
A
Q
V
N
A
V
-
N
-
Q
N
G
C
T
P
L
H
Y
A
A
S
K
N
R
H
E
I
A
V
M
L
L
E
---------------------
G
G
A
N
P
D
A
K
D
----------
H
Y
E
-
A
T
A
M
H
R
A
A
A
K
G
---
N
L
K
M
I
H
I
L
L
Y
Y
---------------------
K
---
A
S
T
N
I
Q
D
T
E
G
N
T
P
L
H
L
A
C
D
E
E
R
-------
V
E
E
A
K
L
L
V
S
Q
G
A
S
I
Y
--------
I
E
N
-
K
E
E
K
T
P
L
Q
---
V
A
K
G
---
G
---
L
---
G
L
I
L
K
R
-
M
-
V
-
E
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
72.35
35%
-61
- C4 -
1UOH
-
PSD10_HUMAN
A:
[37-215]
------------------------------------------------------------------------------------------
D
-
Q
D
S
R
T
A
L
H
W
A
C
S
A
G
H
T
E
I
V
E
F
L
L
Q
L
G
V
----
P
V
N
D
K
D
D
A
G
W
S
P
L
H
I
A
A
S
A
G
R
D
E
I
V
K
A
L
L
G
K
---------
G
----
A
Q
V
N
A
V
-
N
-
Q
N
G
C
T
P
L
H
Y
A
A
S
K
N
R
H
E
I
A
V
M
L
L
E
---------------------
G
G
A
N
P
D
A
K
D
----------
H
Y
E
-
A
T
A
M
H
R
A
A
A
K
G
---
N
L
K
M
I
H
I
L
L
Y
Y
---------------------
K
---
A
S
T
N
I
Q
D
T
E
G
N
T
P
L
H
L
A
C
D
E
E
R
-------
V
E
E
A
K
L
L
V
S
Q
G
A
S
I
Y
--------
I
E
N
-
K
E
E
K
T
P
L
Q
---
V
A
K
G
---
G
---
L
---
G
L
I
L
K
R
-
M
-
V
-
E
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------
110
HHSearch
70.86
25%
-41
- C4 -
2FO1
-
E:
[124-357]
----------------------------------------------------------------------------------------------------------------------------------
H
N
R
T
V
L
H
W
I
A
S
N
S
S
A
E
K
S
E
D
L
I
V
-
H
E
A
K
E
C
I
A
A
G
----
A
D
V
N
A
M
-
D
-
C
D
E
N
T
P
L
M
L
A
V
L
A
R
R
R
R
L
V
A
Y
L
M
K
---------------------
A
G
A
D
P
T
I
Y
N
----------
K
S
E
-
R
S
A
L
H
Q
A
A
A
N
R
---
D
F
G
M
M
V
Y
M
L
N
S
---------------------
T
KLK
G
D
I
E
E
L
D
R
N
G
M
T
A
L
M
I
V
---
A
H
NEGRDQ-
V
A
S
A
K
L
L
V
E
K
G
A
K
V
D
YDGAARKD
S
E
K
-
Y
K
G
R
T
A
L
H
---
Y
A
A
Q
---
V
---
S
NMP
I
V
K
Y
L
V
-
G
E
K
-
G
S
N
K
D
K
Q
D
E
D
G
K
T
P
I
M
L
A
A
Q
E
G
R
I
E
V
V
M
Y
L
I
Q
Q
G
A
S
V
E
A
V
D
A
T
D
H
T
A
R
Q
L
A
Q
A
N
N
H
H
N
I
V
D
I
F
D
R
C
R
--------------------------------------------------------------------------------------------
6
PsiBlast_PDB
70.37
41%
-60
- C4 -
4GMR
1
?
A:
[11-160]
---------------------------------------------------------------
A
A
E
N
G
N
K
D
R
V
K
D
L
L
-
E
---
N
G
A
D
V
N
A
S
D
-
S
D
G
K
T
P
L
H
L
A
A
E
N
G
H
K
E
V
V
K
L
L
L
S
Q
G
A
----
D
P
N
A
K
D
S
D
G
K
T
P
L
H
L
A
A
E
N
G
H
K
E
V
V
K
L
L
L
S
Q
---------
G
----
A
D
P
N
A
K
-
D
-
S
D
G
K
T
P
L
H
L
A
A
E
N
G
H
K
E
V
V
K
L
L
L
S
---------------------
Q
G
A
D
P
N
T
S
D
----------
S
D
G
-
R
T
P
L
D
L
A
R
E
H
G
---
N
E
E
V
V
K
L
L
E
K
Q
---------------------
G
---
G
W
L
E
H
H
H
H
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------