@TOME V2.3
(Nov 2016)

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3D Common Core:

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Modeller Result :

Complexes Modeling
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Values color: [ Good | Correct | Middling | Bad ]Sequence color : MutatedHelixStrandConserved

Query sequence : Wbm0367: (2015-11-30 )
MSTPITVAYGDGIGPEIMEAVLSMLREAEAKISIDVIEIGERVYNKEWSYGISPSGWESIERTKVLLKSPTTTSQGKGHKSLNVALRKSLGLYANIRPCTSYHPVIENKFDRFDIVVIRENEEDVYTGIEHRLTGNSYQCTKIITRSGSEKICRYAFNYAKRHNRKKVTCLTKDNIMKMTDGIFHTAFDSIAKEYPDIKAEHYIVDIGMARVATEPENFDVIVTENLYGDILSDIVAQTSGSVGLAGSSNIGSEYAMFEAVHGSAPNIAGKNIANPSGLLNAAVHMLIYIGQADVAKLVHDAWLKTLEDGIHTADLYKEKKSKQKVGTKEFAEAVIDNIGKKPGILPELIISNGVSSKISKIQGNCEQDYKVRKLVGSDITLAWDKSSNFNQIVKLFESSNPKVIAIYSKGLAIWPGDSKSLSDQVTCRFIANNEKKTITNIDVNNLLIKLERNSFDVVRMDKLYLYDEKEGFFS

Atome Classification :

(41 SA) ----------------.........--10......-------..20.....--..-------.-------30----------.-----.......----40.---....--.-..--50.....-...60-........70.------------------....--.------..80........90........100-.--....-.-.-----110-.--.-.......120.......130---------.-----------------------..----.-----------------------.-----------------------..-----..140--------..----------------------.-------------------------.....150.......160------------.------------......170.......180..--------------..-..---.190.-.----..---------------.--------------------------------.--------------------------------..200-----------...------....210.......220.........230...-....240........250.--.--.....260.......270......-.280.......-290.......300.......310.--.----.......320----.......330.......340.......350.......360.......370........380...--....390.......----400-.......410....--...420.........430.......440.......450.......460.......470...-----
(Atome) (Ident) (Tito) (Num) (Ligand) (Uniprot) ----------------MSTPITVAY--GDGIGPEI-------MEAVLSMLR--EA-------E-------AK----------I-----SIDVIEI----GER---VYNK--E-WS--YGISPSG-WESIE-RTKVLLKSPTT------------------TSQG--K------GHKSLNVALRKSLGLYANIRPCTSY-H--PVIE-N-K-----F---D--R-FDIVVIRENEEDVYTGIE-----------H-----------------------RL----T-----------------------G-----------------------NS-----YQCT---------KI----------------------I-------------------------TRSGSEKICRYAFNYAKR------------H------------NRKKVTCLTKDNIMKMTDGIF--------------HT-AF---DS-IA-K----EY---------------P--------------------------------D--------------------------------IKAEH-----------YIV------DIGMARVATEPENFD--VIVTENLYGDILSDI-VAQTS-GSVGLAGSSNIGS--E--YAMFEAVHGSAPNIAGKNIANPSG-LLNAAVHMLIY-IGQADVAKLVHDAWLKTLEDG--I--H----TADLYKEKKS----KQKVGTKEFAEAVIDNIGKKPGILPELIISNGVSSKISKIQGNCEQDY-KVRKLVGSDITLAWD--KSSNFNQIVKLFES----SNP-KVIAIYSKGLAIWP--GDSK--SLSDQVTCRFIANNEKKTITNIDVNNLLIKLERNSFDVVRMDKLYLYDEKEGFFS-----
87 HHSearch 93.8539% -83 - C5 -2D1C IDH_THET8 A:[19-491] -----------------RKLITVIP--GDGIGPEC-------VEATLKVLE--AA-------K-------AP----------L-----AYEVREA----GAS---VFRR--G-IA--SGVPQET-IESIR-KTRVVLKGPLE------------------TPVG--Y------GEKSANVTLRKLFETYANVRPVREF-P--NV-P-T-P-----Y---AGRG-IDLVVVRENVEDLYAGIE-----------H-----------------------MQ----T-----------------------P-----------------------SV-----AQTL---------KL----------------------I-------------------------SWKGSEKIVRFAFELARA------------E------------GRKKVHCATKSNIMKLAEGTL--------------KR-AF---EQ-VA-Q----EY---------------P--------------------------------D--------------------------------IEAVH-----------IIV------DNAAHQLVKRPEQFE--VIVTTNMNGDILSDL-TSGLI-GGLGFAPSANIGN--E--VAIFEAVHGSAPKYAGKNVINPTA-VLLSAVMMLRY-LEEFATADLIENALLYTLEEGR-V--L----TGDVVGYD-------RGAKTTEYTEAIIQNLGKTPRKTQVRGYKPFRLPQ--VDGAIAPIVP-RSRRVVGVDVFVETN----LLPEALGKALEDLAAGTPF-RLKMISNRGTQVYP--PTGGLTDLVDHYRCRFLYTGEG-EAKDPEILDLVSRVAS-RFRWMHLEKLQEFDGEPGFTK-----
1 PsiBlast_PDB 92.5838% -80 - C5 -2D1C IDH_THET8 A:[22-489] --------------------ITVIP--GDGIGPEC-------VEATLKVLE--AA-------K-------AP----------L-----AYEVREA----GAS---VFRR--G-IA--SGVPQET-IESIR-KTRVVLKGPLE------------------TPVG--Y------GEKSANVTLRKLFETYANVRPVREF-P--NVPT-P-Y-----A---G--RGIDLVVVRENVEDLYAGIE-----------H-----------------------MQ----T-----------------------P-----------------------SV-----AQTL---------KL----------------------I-------------------------SWKGSEKIVRFAFELARA------------E------------GRKKVHCATKSNIMKLAEGTL--------------KR-AF---EQ-VA-Q----EY---------------P--------------------------------D--------------------------------IEAVH-----------IIV------DNAAHQLVKRPEQFE--VIVTTNMNGDILSDL-TSGLI-GGLGFAPSANIGN--E--VAIFEAVHGSAPKYAGKNVINPTA-VLLSAVMMLRY-LEEFATADLIENALLYTLEEGR-V--L----TGDVVGYDRG----AK---TTEYTEAIIQNLGKTPR---KTQVRGYKPFRLPQVDGAIAPIVPRSRRVVGVDVFVETNL-LPEALGKALEDLAA----GTPFRLKMISNRGTQVYPPTGGLT--DLVDHYRCRFLYTGEGEA-KDPEILDLVSRVA-SRFRWMHLEKLQEFDGEPGFTK-----
21 PsiBlast_CBE 92.2138% -79 - C5 -2D1C IDH_THET8 B:[22-489] --------------------ITVIP--GDGIGPEC-------VEATLKVLE--AA-------K-------AP----------L-----AYEVREA----GAS---VFRR--G-IA--SGVPQET-IESIR-KTRVVLKGPLE------------------TPVG--Y------GEKSANVTLRKLFETYANVRPVREF-P--NVPT-P-Y-----A---G--RGIDLVVVRENVEDLYAGIE-----------H-----------------------MQ----T-----------------------P-----------------------SV-----AQTL---------KL----------------------I-------------------------SWKGSEKIVRFAFELARA------------E------------GRKKVHCATKSNIMKLAEGTL--------------KR-AF---EQ-VA-Q----EY---------------P--------------------------------D--------------------------------IEAVH-----------IIV------DNAAHQLVKRPEQFE--VIVTTNMNGDILSDL-TSGLI-GGLGFAPSANIGN--E--VAIFEAVHGSAPKYAGKNVINPTA-VLLSAVMMLRY-LEEFATADLIENALLYTLEEGR-V--L----TGDVVGYDRG----AK---TTEYTEAIIQNLGKTPR---KTQVRGYKPFRLPQVDGAIAPIVPRSRRVVGVDVFVETNL-LPEALGKALEDLAA----GTPFRLKMISNRGTQVYPPTGGLT--DLVDHYRCRFLYTGEGEA-KDPEILDLVSRVA-SRFRWMHLEKLQEFDGEPGFTK-----
109 Fugue 91.6838% -78 - C5 -2D1C IDH_THET8 A:[2-496] PLITTETGKKMHVLEDGRKLITVIP--GDGIGPEC-------VEATLKVLE--AA-------K-------AP----------L-----AYEVREA----GAS---VFRR--G-IA--SGVPQET-IESIR-KTRVVLKGPLE------------------TPVG--Y------GEKSANVTLRKLFETYANVRPVREF-P--NVPT-PYA-----G---R--G-IDLVVVRENVEDLYAGIE-----------H-----------------------MQ----T-----------------------P-----------------------SV-----AQTL---------KL----------------------I-------------------------SWKGSEKIVRFAFELARA------------E------------GRKKVHCATKSNIMKLAEGTL--------------KR-AF---EQ-VA-Q----EY---------------P--------------------------------D--------------------------------IEAVH-----------IIV------DNAAHQLVKRPEQFE--VIVTTNMNGDILSDL-TSGLI-GGLGFAPSANIGN--E--VAIFEAVHGSAPKYAGKNVINPTA-VLLSAVMMLRY-LEEFATADLIENALLYTLEEGR-V--L----TGDVVGYDRG----A---KTTEYTEAIIQNLGKTPRKTQVRGYKPFRLPQVDGAIAP--IVP-RSRRVVGVDVFVETNLLPEALGKALEDLAAG----TPF-RLKMISNRGTQVYPPTGGLT--DLVDHYRCRFLYTGEG-EAKDPEILDLVSRVASR-FRWMHLEKLQEFDGEPGFTKAQGED
103 HHSearch 81.2033% -82 - C5 -1TYO ? A:[34-426] ----------------DNPVVAFIR--GDGVGPEV-------VESALKVVD--AA-------VKKVYGGSRR----------I-----VWWELLA----GHL---AREK----CG--ELLPKAT-LEGIR-LARVALKGPLE------------------TPVG--T------GYRSLNVAIRQALDLYANIRPVRYY----GQ-P-A-PHKY--A---D--R-VDMVIFRENTEDVYAGIE-----------W-----------------------PH----DSPEAARIRRFLAEEFGISIR---E-----------------------DA-----GIGV---------KP----------------------I-------------------------SRFATRRLMERALEWALR------------N------------GNTVVTIMHKGNIMKYTEGAF--------------MR-WA---YE-VALE----KFREHVVTEQEVQEKY-GGVRPEG--------------------------K--------------------------------ILVND-----------RIA------DNMLQQIITRPWDYQ--VIVAPNLNGDYISDA-ASALV-GGIGMAAGMNMGD--G--IAVAEPVHGTAPKYAGKDLINPSA-EILSASLLIGEFMGWREVKSIVEYAIRKAVQSK--K--V----TQDLARHMPG----VQPLRTSEYTETLIAYIDEADLNEVLAG----------------------------------------------------------------------------------------------------------------------------------------------
100 HHSearch 79.7637% -81 - C5 -2IV0 IDH_ARCFU A:[27-411] -----------------NPIIPYFE--GDGIGKDV-------VPAAIRVLD--AA-------ADKIG---KE----------V-----VWFQVYA----GED---AYKL----YG--NYLPDDT-LNAIK-EFRVALKGPLT------------------TPVG--G------GYRSLNVTIRQVLDLYANVRPVYYL-K--GV-P-S-PIKH--P---E--K-VNFVIFRENTEDVYAGIE-----------W-----------------------PR----GSEEALKLIRFLKNEFGVTIR---E-----------------------DS-----GIGI---------KP----------------------I-------------------------SEFATKRLVRMAIRYAIE------------N------------NRKSVTLVHKGNIMKYTEGAF--------------RD-WG---YE-VA-KQ---EF---------------GEYCITEDELWDKYGGKQPEG------------K--------------------------------IVVKD-----------RIA------DNMFQQILTRTDEYD--VIALPNLNGDYLSDA-AAALI-GGLGIAPGSNIGD--G--IGVFEPVHGSAPKYAGQNKVNPTA-EILTGALMFEY-IGWKDASEMIKKAVEMTISSG--I--V----TYDIHRHM-G----GTKVGTREFAEAVVENLQSL------------------------------------------------------------------------------------------------------------------------------------------------------
96 HHSearch 78.4533% -75 - C5 -2D4V ? A:[25-429] ----------------DQPIIPFIE--GDGIGCDV-------TPAMRSVVD--AA-------VAKVYGGQRQ----------I-----AWMELFA----GQK---AVQL--YGEG--QYLPDET-MAAIR-EYKVAIKGPLE------------------TPVG--G------GIRSLNVAMRQDLDLYVCLRPVRYF-E--GT-P-S-PMRH--P---E--K-VDMVIFRENSEDIYAGIE-----------W-----------------------PA----GSPEAEKIIRFLREEMGVTKIRFPD-----------------------SS-----AIGI---------KP----------------------V-------------------------STEGSERLIRRTIQYALE------------H------------GKPSVSLVHKGNIMKFTEGGF--------------RD-WG---YA-LAER----EF---------------AGRVFTWRQKAAISKAEGKAAGQKAEQQAIADGK--------------------------------LIIKD-----------VIA------DNFLQQILLRPEDYS--VVATLNLNGDYVSDA-LAAEV-GGIGMAPGANLSD--T--HAIFEATHGTAPDIAGQGKANPSS-LILSAVMMLEH-LGWGEAAQAIVAAMNATIAAG--E--V----TGDLAALRGD----VPALSTTEFTAALIRRF---------------------------------------------------------------------------------------------------------------------------------------------------------
108 HHSearch 75.3136% -78 - C5 -1HQS IDH_BACSU A:[18-423] ----------------NNPIIPFIE--GDGTGPDI-------WNAASKVLE--AA-------VEKAYKGEKK----------I-----TWKEVYA----GEK---AYNK----TG--EWLPAET-LDVIR-EYFIAIKGPLT------------------TPVG--G------GIRSLNVALRQELDLFVCLRPVRYF-T--GV-P-S-PVKR--P---E--D-TDMVIFRENTEDIYAGIE-----------Y-----------------------AK----G-----------------------SEEVQKLISFLQNELNVNKIRFPETS-----GIGI---------KP----------------------V-------------------------SEEGTSRLVRAAIDYAIE------------H------------GRKSVTLVHKGNIMKFTEGAF--------------KN-WG---YE-LAEK----EY---------------G--------------------------------DKVFTWAQYDRIAEEQGKDAANKAQSEAEAAGKIIIKD-----------SIA------DIFLQQILTRPNEFD--VVATMNLNGDYISDA-LAAQV-GGIGIAPGANINYETG--HAIFEATHGTAPKYAGLDKVNPSS-VILSGVLLLEH-LGWNEAADLVIKSMEKTIASK--V--V----TYDFARLMDG----ATEVKCSEFGEELIKNMD--------------------------------------------------------------------------------------------------------------------------------------------------------
97 HHSearch 75.2935% -85 - C5 -3TY4 LYS12_SCHPO A:[9-364] ----------------RRIVLGLIP--ADGIGKEV-------VPAARRLME--NL-------PAKHK---LK----------F-----DFIDLDA----GWG---TFER----TG--KALPERT-VERLKTECNAALFGAVQ------------------SPTHKVA------GYSSPIVALRKKMGLYANVRPVKSL-D--GA-K---------G---K--P-VDLVIVRENTECLYVKEE-----------R-----------------------MVQNTPG-----------------------K-----------------------RV-----AEAI---------RR----------------------I-------------------------SEEASTKIGKMAFEIAKS------------RQKIRESGTYSIHKKPLVTIIHKSNVMSVTDGLF--------------RE-SC---RH-AQ-SLDP-SY---------------A--------------------------------S--------------------------------INVDE-----------QIV------DSMVYRLFREPECFD--VVVAPNLYGDILSDG-AASLI-GSLGLVPSANVGD--N--FVMSEPVHGSAPDIAGRGIANPVA-TFRSVALMLEF-MGHQDAAADIYTAVDKVLTEGK-V--L----TPDLGGK----------SGTNEITDAVLANI---------------------------------------------------------------------------------------------------------------------------------------------------------
89 HHSearch 74.6940% -86 - C5 -3BLX - IDH2_YEAST B:[21-354] -----------------KYTVSFIE--GDGIGPEI-------SKSVKKIFS--AA-------N-------VP----------I-----EWESCDV----SPI----FVN----GL--TTIPDPA-VQSIT-KNLVALKGPLA------------------TP------------HRSLNLTLRKTFGLFANVRPAKSI-E--GF-K-T-T-----Y---E--N-VDLVLIRENTEGEYSGIE-----------H-----------------------IV----C-----------------------P-----------------------GV-----VQSI---------KL----------------------I-------------------------TRDASERVIRYAFEYARA------------I------------GRPRVIVVHKSTIQRLADGLF--------------VN-VA---KE-LS-K----EY---------------P--------------------------------D--------------------------------LTLET-----------ELI------DNSVLKVVTNPSAYTDAVSVCPNLYGDILSDL-NSGLSAGSLGLTPSANIGH--K--ISIFEAVHGSAPDIAGQDKANPTA-LLLSSVMMLNH-MGLTNHADQIQNAVLSTIASGPEN--R----TGDLAGT----------ATTSSFTEAVIKRL---------------------------------------------------------------------------------------------------------------------------------------------------------
88 HHSearch 74.4035% -85 - C5 -1X0L - HICDH_THET2 A:[2-333] -----------------AYRICLIE--GDGIGHEV-------IPAARRVLE--AT-------G-------LP----------L-----EFVEAEA----GWE---TFER----RG--TSVPEET-VEKIL-SCHATLFGAAT------------------SPTRKVP------GFFGAIRYLRRRLDLYANVRPAKSR-P--VP---G-S-----R---P--G-VDLVIVRENTEGLYVEQE-----------R-----------------------RY----------------------------L-----------------------DV-----AIAD---------AV----------------------I-------------------------SKKASERIGRAALRIAEG------------R------------PRKTLHIAHKANVLPLTQGLF--------------LD-TV---KE-VA-K----DF---------------P--------------------------------L--------------------------------VNVQD-----------IIV------DNCAMQLVMRPERFD--VIVTTNLLGDILSDL-AAGLV-GGLGLAPSGNIGD--T--TAVFEPVHGSAPDIAGKGIANPTA-AILSAAMMLDY-LGEKEAAKRVEKAVDLVLERG--P--R----TPDLGGD----------ATTEAFTEAVVEALKSL------------------------------------------------------------------------------------------------------------------------------------------------------
38 PsiBlast_CBE 74.1435% -79 - C5 -2IV0 IDH_ARCFU B:[35-409] ---------------------------GDGIGKDV-------VPAAIRVLD--AA-------A-------DK----------I-----GKEVVWFQVYAGED---AYKL--Y-GN--Y-LPDDT-LNAIK-EFRVALKGPLT------------------TPVG--G------GYRSLNVTIRQVLDLYANVRPVYYL-KGVPSPI-K-H-----P---E--K-VNFVIFRENTEDVYAGIE-----------WPRGSEEALKLI------------RF----L-----------------------K-----------------------NE-----FGVTIREDSGIGIKP----------------------I-------------------------SEFATKRLVRMAIRYAIE------------N------------NRKSVTLVHKGNIMKYTEGAF--------------RD-WG---YE-VA-KQEFGEYCITEDELWDKYGGKQP--------------------------------EGK------------------------------IVVKD-----------RIA------DNMFQQILTRTDEYD--VIALPNLNGDYLSDA-AAALI-GGLGIAPGSNIGD--G--IGVFEPVHGSAPKYAGQNKVNPTA-EILTGALMFEY-IGWKDASEMIKKAVEMTISSG--I--V----TYDIHRH-MG----GTKVGTREFAEAVVENLQSL------------------------------------------------------------------------------------------------------------------------------------------------------
2 PsiBlast_PDB 72.9839% -86 - C5 -3BLW IDH2_YEAST B:[23-354] ---------------------TVSFIEGDGIGPEI-------SKSVKKIFS--AA-------N-------VP----------I-----EWESCDV----SPI---FVNG--L-TT----IPDPA-VQSIT-KNLVALKGPLA------------------TP------------HRSLNLTLRKTFGLFANVRPAKSI-E--G-FK-T-T-----Y---E--N-VDLVLIRENTEGEYSGIE-----------H-----------------------IV----C-----------------------P-----------------------GV-----VQSI---------KL----------------------I-------------------------TRDASERVIRYAFEYARA------------I------------GRPRVIVVHKSTIQRLADGLF--------------VN-VA---KE-LS-K----EY---------------P--------------------------------D--------------------------------LTLET-----------ELI------DNSVLKVVTNPSAYTDAVSVCPNLYGDILSDLNSGLSA-GSLGLTPSANIGH--K--ISIFEAVHGSAPDIAGQDKANPTA-LLLSSVMMLNH-MGLTNHADQIQNAVLSTIASG--PENR----TGDLAGTAT----------TSSFTEAVIKRL---------------------------------------------------------------------------------------------------------------------------------------------------------
23 PsiBlast_CBE 72.9039% -87 - C5 -3BLW IDH2_YEAST N:[23-354] ---------------------TVSFIEGDGIGPEI-------SKSVKKIFS--AA-------N-------VP----------I-----EWESCDV----SPI---FVNG--L-TT----IPDPA-VQSIT-KNLVALKGPLA------------------TP------------HRSLNLTLRKTFGLFANVRPAKSI-E--G-FK-T-T-----Y---E--N-VDLVLIRENTEGEYSGIE-----------H-----------------------IV----C-----------------------P-----------------------GV-----VQSI---------KL----------------------I-------------------------TRDASERVIRYAFEYARA------------I------------GRPRVIVVHKSTIQRLADGLF--------------VN-VA---KE-LS-K----EY---------------P--------------------------------D--------------------------------LTLET-----------ELI------DNSVLKVVTNPSAYTDAVSVCPNLYGDILSDLNSGLSA-GSLGLTPSANIGH--K--ISIFEAVHGSAPDIAGQDKANPTA-LLLSSVMMLNH-MGLTNHADQIQNAVLSTIASG--PENR----TGDLAGTAT----------TSSFTEAVIKRL---------------------------------------------------------------------------------------------------------------------------------------------------------
25 PsiBlast_CBE 72.8839% -86 - C5 -3BLW IDH2_YEAST J:[23-354] ---------------------TVSFIEGDGIGPEI-------SKSVKKIFS--AA-------N-------VP----------I-----EWESCDV----SPI---FVNG--L-TT----IPDPA-VQSIT-KNLVALKGPLA------------------TP------------HRSLNLTLRKTFGLFANVRPAKSI-E--G-FK-T-T-----Y---E--N-VDLVLIRENTEGEYSGIE-----------H-----------------------IV----C-----------------------P-----------------------GV-----VQSI---------KL----------------------I-------------------------TRDASERVIRYAFEYARA------------I------------GRPRVIVVHKSTIQRLADGLF--------------VN-VA---KE-LS-K----EY---------------P--------------------------------D--------------------------------LTLET-----------ELI------DNSVLKVVTNPSAYTDAVSVCPNLYGDILSDLNSGLSA-GSLGLTPSANIGH--K--ISIFEAVHGSAPDIAGQDKANPTA-LLLSSVMMLNH-MGLTNHADQIQNAVLSTIASG--PENR----TGDLAGTAT----------TSSFTEAVIKRL---------------------------------------------------------------------------------------------------------------------------------------------------------
24 PsiBlast_CBE 72.7039% -87 - C5 -3BLW IDH2_YEAST L:[23-354] ---------------------TVSFIEGDGIGPEI-------SKSVKKIFS--AA-------N-------VP----------I-----EWESCDV----SPI---FVNG--L-TT----IPDPA-VQSIT-KNLVALKGPLA------------------TP------------HRSLNLTLRKTFGLFANVRPAKSI-E--G-FK-T-T-----Y---E--N-VDLVLIRENTEGEYSGIE-----------H-----------------------IV----C-----------------------P-----------------------GV-----VQSI---------KL----------------------I-------------------------TRDASERVIRYAFEYARA------------I------------GRPRVIVVHKSTIQRLADGLF--------------VN-VA---KE-LS-K----EY---------------P--------------------------------D--------------------------------LTLET-----------ELI------DNSVLKVVTNPSAYTDAVSVCPNLYGDILSDLNSGLSA-GSLGLTPSANIGH--K--ISIFEAVHGSAPDIAGQDKANPTA-LLLSSVMMLNH-MGLTNHADQIQNAVLSTIASG--PENR----TGDLAGTAT----------TSSFTEAVIKRL---------------------------------------------------------------------------------------------------------------------------------------------------------
22 PsiBlast_CBE 72.7039% -87 - C5 -3BLW IDH2_YEAST P:[23-354] ---------------------TVSFIEGDGIGPEI-------SKSVKKIFS--AA-------N-------VP----------I-----EWESCDV----SPI---FVNG--L-TT----IPDPA-VQSIT-KNLVALKGPLA------------------TP------------HRSLNLTLRKTFGLFANVRPAKSI-E--G-FK-T-T-----Y---E--N-VDLVLIRENTEGEYSGIE-----------H-----------------------IV----C-----------------------P-----------------------GV-----VQSI---------KL----------------------I-------------------------TRDASERVIRYAFEYARA------------I------------GRPRVIVVHKSTIQRLADGLF--------------VN-VA---KE-LS-K----EY---------------P--------------------------------D--------------------------------LTLET-----------ELI------DNSVLKVVTNPSAYTDAVSVCPNLYGDILSDLNSGLSA-GSLGLTPSANIGH--K--ISIFEAVHGSAPDIAGQDKANPTA-LLLSSVMMLNH-MGLTNHADQIQNAVLSTIASG--PENR----TGDLAGTAT----------TSSFTEAVIKRL---------------------------------------------------------------------------------------------------------------------------------------------------------
101 HHSearch 72.6933% -75 - C5 -3DMS - ? A:[27-419] ----------------DQPIIPYIE--GDGTGFDI-------TPVMIKVVD--AA-------VEKAYGGKKK----------I-----HWMEIYA----GEK---ATKV----YGPDVWLPEET-LQVLK-EYVVSIKGPLT------------------TPV------------RSLNVALRQELDLYVCLRPIQYF-K--GV-P-S-PVRE--P---E--K-TNMVIFRENSEDIYAGIE-----------W-----------------------AA----ESEQAKKVIKFLQEEMGVKKIRFPQ-----------------------TS-----GIGI---------KP----------------------V-------------------------SKEGTERLVRKAIQYAID------------N------------DRKSVTLVHKGNIMKFTEGAF--------------RD-AG---YA-LAQK----EFGAELIDGGPWMKFKNPKTGN----------------------------E--------------------------------IVVKD-----------SIA------DAFLQQILLRPAEYD--VIATLNLNGDYISDA-LAAQV-GGIGIAPGANLSD--S--VAMFEATHGTAPKYAGKDYVNPGS-EILSAEMMLRH-LGWTEAADVIISAMEKSIKQK--R--V----TYDFARLMEG----ATQVSCSGFGQVLIENME--------------------------------------------------------------------------------------------------------------------------------------------------------
27 PsiBlast_CBE 72.6439% -86 - C5 -3BLW IDH2_YEAST F:[23-354] ---------------------TVSFIEGDGIGPEI-------SKSVKKIFS--AA-------N-------VP----------I-----EWESCDV----SPI---FVNG--L-TT----IPDPA-VQSIT-KNLVALKGPLA------------------TP------------HRSLNLTLRKTFGLFANVRPAKSI-E--G-FK-T-T-----Y---E--N-VDLVLIRENTEGEYSGIE-----------H-----------------------IV----C-----------------------P-----------------------GV-----VQSI---------KL----------------------I-------------------------TRDASERVIRYAFEYARA------------I------------GRPRVIVVHKSTIQRLADGLF--------------VN-VA---KE-LS-K----EY---------------P--------------------------------D--------------------------------LTLET-----------ELI------DNSVLKVVTNPSAYTDAVSVCPNLYGDILSDLNSGLSA-GSLGLTPSANIGH--K--ISIFEAVHGSAPDIAGQDKANPTA-LLLSSVMMLNH-MGLTNHADQIQNAVLSTIASG--PENR----TGDLAGTAT----------TSSFTEAVIKRL---------------------------------------------------------------------------------------------------------------------------------------------------------
28 PsiBlast_CBE 72.6039% -87 - C5 -3BLW IDH2_YEAST D:[23-354] ---------------------TVSFIEGDGIGPEI-------SKSVKKIFS--AA-------N-------VP----------I-----EWESCDV----SPI---FVNG--L-TT----IPDPA-VQSIT-KNLVALKGPLA------------------TP------------HRSLNLTLRKTFGLFANVRPAKSI-E--G-FK-T-T-----Y---E--N-VDLVLIRENTEGEYSGIE-----------H-----------------------IV----C-----------------------P-----------------------GV-----VQSI---------KL----------------------I-------------------------TRDASERVIRYAFEYARA------------I------------GRPRVIVVHKSTIQRLADGLF--------------VN-VA---KE-LS-K----EY---------------P--------------------------------D--------------------------------LTLET-----------ELI------DNSVLKVVTNPSAYTDAVSVCPNLYGDILSDLNSGLSA-GSLGLTPSANIGH--K--ISIFEAVHGSAPDIAGQDKANPTA-LLLSSVMMLNH-MGLTNHADQIQNAVLSTIASG--PENR----TGDLAGTAT----------TSSFTEAVIKRL---------------------------------------------------------------------------------------------------------------------------------------------------------
56 PsiBlast_CBE 72.0131% -77 - C5 -1P8F IDH_ECOLI A:[34-416] ---------------------------GDGIGVDV-------TPAMLKVVD--AAVEKAYKGE-------RK----------I-----SWMEIYT----GEKSTQVYGQ--DVW-----LPAET-LDLIR-EYRVAIKGPLT------------------TPVG--G------GIRSLNVALRQELDLYICLRPVRYY-QGTPSPV-K-H-----P---E--L-TDMVIFRENSEDIYAGIE-----------W-----------------------K-----------------------------A-----------------------DS-----ADAE---------KV----------------------IKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIA------------N------------DRDSVTLVHKGNIMKFTEGAF--------------KD-WG---YQ-LA-R----EEFGGELIDGG------P--------------------------------W--------------------------------LKVKNPNTGKEIVIKDVIA------DAFLQQILLRPAEYD--VIACMNLNGDYISDA-LAAQV-GGIGIAPGANIGD--E--CALFEATHGTAPKYAGQDKVNPGS-IILSAEMMLRH-MGWTEAADLI----VKGMEGA--I--NAKTVTYDFERLMDG----AKLLKCSEFGDAIIENM---------------------------------------------------------------------------------------------------------------------------------------------------------
60 PsiBlast_CBE 71.8931% -76 - C5 -1CW7