@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0367: (2015-11-30 )
MSTPITVAYGDGIGPEIMEAVLSMLREAEAKISIDVIEIGERVYNKEWSYGISPSGWESIERTKVLLKSPTTTSQGKGHKSLNVALRKSLGLYANIRPCTSYHPVIENKFDRFDIVVIRENEEDVYTGIEHRLTGNSYQCTKIITRSGSEKICRYAFNYAKRHNRKKVTCLTKDNIMKMTDGIFHTAFDSIAKEYPDIKAEHYIVDIGMARVATEPENFDVIVTENLYGDILSDIVAQTSGSVGLAGSSNIGSEYAMFEAVHGSAPNIAGKNIANPSGLLNAAVHMLIYIGQADVAKLVHDAWLKTLEDGIHTADLYKEKKSKQKVGTKEFAEAVIDNIGKKPGILPELIISNGVSSKISKIQGNCEQDYKVRKLVGSDITLAWDKSSNFNQIVKLFESSNPKVIAIYSKGLAIWPGDSKSLSDQVTCRFIANNEKKTITNIDVNNLLIKLERNSFDVVRMDKLYLYDEKEGFFS
Atome Classification :
(41 SA)
----------------.........--10......-------..20.....--..-------.-------30----------.-----.......----40.---....--.-..--50.....-...60-........70.------------------....--.------..80........90........100-.--....-.-.-----110-.--.-.......120.......130---------.-----------------------..----.-----------------------.-----------------------..-----..140--------..----------------------.-------------------------.....150.......160------------.------------......170.......180..--------------..-..---.190.-.----..---------------.--------------------------------.--------------------------------..200-----------...------....210.......220.........230...-....240........250.--.--.....260.......270......-.280.......-290.......300.......310.--.----.......320----.......330.......340.......350.......360.......370........380...--....390.......----400-.......410....--...420.........430.......440.......450.......460.......470...-----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------MST
P
I
T
V
A
Y--GDGI
G
P
E
I
-------
M
E
A
V
L
S
M
L
R
--EA-------E-------A
K
----------
I
-----
S
I
D
V
I
E
I
----
G
E
R
---
V
YNK--E-WS--YGISPS
G
-
W
E
S
I
E
-
R
T
K
V
L
L
KSPTT------------------TSQG--K------GH
K
S
L
N
V
A
L
R
K
SLG
L
Y
A
NIRPCTSY-H--
P
V
I
E-N-K-----F---D--
R
-
F
D
I
V
V
I
RENE
E
D
V
Y
T
G
I
E
-----------H-----------------------RL----T-----------------------G-----------------------NS-----
Y
Q
C
T
---------
K
I
----------------------
I
-------------------------TRSG
S
E
K
I
C
R
Y
A
F
N
Y
A
K
R------------H------------NR
K
K
V
T
C
LTKD
N
I
M
K
M
T
D
G
I
F
--------------
H
T
-
A
F
---
D
S
-
I
A
-
K
----EY---------------P--------------------------------D--------------------------------IKA
E
H
-----------
Y
I
V
------DIG
M
A
RVATEPE
N
F
D
--
V
I
V
T
E
N
L
Y
G
D
I
L
S
D
I
-
V
A
QTS-GSVGLAGSSNIG
S
--
E
--
Y
A
M
F
E
A
VHGSAPNIAGKNIA
N
P
S
G
-
L
L
N
A
A
V
H
M
L
I
Y
-I
G
Q
A
D
V
A
K
L
V
H
D
A
W
L
K
T
L
E
DG--I--
H
----
T
A
D
L
Y
K
E
K
K
S
----KQKV
G
T
K
E
F
A
E
A
V
I
D
NIGKKPGI
L
P
E
L
I
ISNG
V
S
S
K
I
S
K
IQGNCEQ
D
Y
-
K
V
R
K
LVGS
D
I
T
L
A
WD--KSS
N
F
N
Q
I
V
K
L
F
ES----SNP-
K
V
I
A
I
YSK
G
L
A
IWP--GDSK--SLSD
Q
V
T
C
R
F
I
ANNEK
K
T
I
T
N
IDVN
N
L
L
I
K
L
ERNS
F
D
V
V
R
M
D
K
L
Y
L
Y
DEKEGFFS-----
87
HHSearch
93.85
39%
-83
- C5 -
2D1C
4
IDH_THET8
A:
[19-491]
-----------------
R
K
L
I
T
V
I
P
--
G
D
G
I
G
P
E
C
-------
V
E
A
T
L
K
V
L
E
--
A
A
-------
K
-------
A
P
----------
L
-----
A
Y
E
V
R
E
A
----
G
A
S
---
V
F
R
R
--
G
-
I
A
--
S
G
V
P
Q
E
T
-
I
E
S
I
R
-
K
T
R
V
V
L
K
G
P
L
E
------------------
T
P
V
G
--
Y
------
G
E
K
S
A
N
V
T
L
R
K
L
F
E
T
Y
A
N
V
R
P
V
R
E
F
-
P
--
N
V
-
P
-
T
-
P
-----
Y
---
A
GR
G
-
I
D
L
V
V
V
R
E
N
V
E
D
L
Y
A
G
I
E
-----------
H
-----------------------
M
Q
----
T
-----------------------
P
-----------------------
S
V
-----
A
Q
T
L
---------
K
L
----------------------
I
-------------------------
S
W
K
G
S
E
K
I
V
R
F
A
F
E
L
A
R
A
------------
E
------------
G
R
K
K
V
H
C
A
T
K
S
N
I
M
K
L
A
E
G
T
L
--------------
K
R
-
A
F
---
E
Q
-
V
A
-
Q
----
E
Y
---------------
P
--------------------------------
D
--------------------------------
I
E
A
V
H
-----------
I
I
V
------
D
N
A
A
H
Q
L
V
K
R
P
E
Q
F
E
--
V
I
V
T
T
N
M
N
G
D
I
L
S
D
L
-
T
S
G
L
I
-
G
G
L
G
F
A
P
S
A
N
I
G
N
--
E
--
V
A
I
F
E
A
V
H
G
S
A
P
K
Y
A
G
K
N
V
I
N
P
T
A
-
V
L
L
S
A
V
M
M
L
R
Y
-
L
E
E
F
A
T
A
D
L
I
E
N
A
L
L
Y
T
L
E
E
G
R-
V
--
L
----
T
G
D
V
V
G
Y
D
-------
R
G
A
K
T
T
E
Y
T
E
A
I
I
Q
N
L
G
K
T
P
R
K
T
Q
V
R
G
Y
K
P
F
R
L
P
Q
--
V
D
G
A
I
A
P
I
V
P
-
R
S
R
R
V
V
G
V
D
V
F
V
E
T
N
----
L
L
P
E
A
L
G
K
A
L
E
D
L
A
AG
T
P
F
-
R
L
K
M
I
S
N
R
G
T
Q
V
Y
P
--
P
T
G
G
L
T
D
L
V
D
H
Y
R
C
R
F
L
Y
T
G
E
G
-
E
A
K
D
P
E
I
L
D
L
V
S
R
V
A
S
-
R
F
R
W
M
H
L
E
K
L
Q
E
F
D
G
E
P
G
F
T
K
-----
1
PsiBlast_PDB
92.58
38%
-80
- C5 -
2D1C
4
IDH_THET8
A:
[22-489]
--------------------
I
T
V
I
P
--
G
D
G
I
G
P
E
C
-------
V
E
A
T
L
K
V
L
E
--
A
A
-------
K
-------
A
P
----------
L
-----
A
Y
E
V
R
E
A
----
G
A
S
---
V
F
R
R
--
G
-
I
A
--
S
G
V
P
Q
E
T
-
I
E
S
I
R
-
K
T
R
V
V
L
K
G
P
L
E
------------------
T
P
V
G
--
Y
------
G
E
K
S
A
N
V
T
L
R
K
L
F
E
T
Y
A
N
V
R
P
V
R
E
F
-
P
--
N
V
P
T
-
P
-
Y
-----
A
---
G
--
R
G
I
D
L
V
V
V
R
E
N
V
E
D
L
Y
A
G
I
E
-----------
H
-----------------------
M
Q
----
T
-----------------------
P
-----------------------
S
V
-----
A
Q
T
L
---------
K
L
----------------------
I
-------------------------
S
W
K
G
S
E
K
I
V
R
F
A
F
E
L
A
R
A
------------
E
------------
G
R
K
K
V
H
C
A
T
K
S
N
I
M
K
L
A
E
G
T
L
--------------
K
R
-
A
F
---
E
Q
-
V
A
-
Q
----
E
Y
---------------
P
--------------------------------
D
--------------------------------
I
E
A
V
H
-----------
I
I
V
------
D
N
A
A
H
Q
L
V
K
R
P
E
Q
F
E
--
V
I
V
T
T
N
M
N
G
D
I
L
S
D
L
-
T
S
G
L
I
-
G
G
L
G
F
A
P
S
A
N
I
G
N
--
E
--
V
A
I
F
E
A
V
H
G
S
A
P
K
Y
A
G
K
N
V
I
N
P
T
A
-
V
L
L
S
A
V
M
M
L
R
Y
-
L
E
E
F
A
T
A
D
L
I
E
N
A
L
L
Y
T
L
E
E
G
R-
V
--
L
----
T
G
D
V
V
G
Y
D
R
G
----
A
K
---
T
T
E
Y
T
E
A
I
I
Q
N
L
G
K
T
P
R
---
K
T
Q
V
R
G
Y
K
P
F
R
L
P
Q
V
D
G
A
I
A
P
I
V
P
R
S
R
R
V
V
G
V
D
V
F
V
E
T
N
L-
L
P
E
A
L
G
K
A
L
E
D
L
A
A
----
G
T
P
F
R
L
K
M
I
S
N
R
G
T
Q
V
Y
P
PT
G
G
L
T
--
D
L
V
D
H
Y
R
C
R
F
L
Y
T
G
E
G
E
A
-
K
D
P
E
I
L
D
L
V
S
R
V
A
-
S
R
F
R
W
M
H
L
E
K
L
Q
E
F
D
G
E
P
G
F
T
K
-----
21
PsiBlast_CBE
92.21
38%
-79
- C5 -
2D1C
4
IDH_THET8
B:
[22-489]
--------------------
I
T
V
I
P
--
G
D
G
I
G
P
E
C
-------
V
E
A
T
L
K
V
L
E
--
A
A
-------
K
-------
A
P
----------
L
-----
A
Y
E
V
R
E
A
----
G
A
S
---
V
F
R
R
--
G
-
I
A
--
S
G
V
P
Q
E
T
-
I
E
S
I
R
-
K
T
R
V
V
L
K
G
P
L
E
------------------
T
P
V
G
--
Y
------
G
E
K
S
A
N
V
T
L
R
K
L
F
E
T
Y
A
N
V
R
P
V
R
E
F
-
P
--
N
V
P
T
-
P
-
Y
-----
A
---
G
--
R
G
I
D
L
V
V
V
R
E
N
V
E
D
L
Y
A
G
I
E
-----------
H
-----------------------
M
Q
----
T
-----------------------
P
-----------------------
S
V
-----
A
Q
T
L
---------
K
L
----------------------
I
-------------------------
S
W
K
G
S
E
K
I
V
R
F
A
F
E
L
A
R
A
------------
E
------------
G
R
K
K
V
H
C
A
T
K
S
N
I
M
K
L
A
E
G
T
L
--------------
K
R
-
A
F
---
E
Q
-
V
A
-
Q
----
E
Y
---------------
P
--------------------------------
D
--------------------------------
I
E
A
V
H
-----------
I
I
V
------
D
N
A
A
H
Q
L
V
K
R
P
E
Q
F
E
--
V
I
V
T
T
N
M
N
G
D
I
L
S
D
L
-
T
S
G
L
I
-
G
G
L
G
F
A
P
S
A
N
I
G
N
--
E
--
V
A
I
F
E
A
V
H
G
S
A
P
K
Y
A
G
K
N
V
I
N
P
T
A
-
V
L
L
S
A
V
M
M
L
R
Y
-
L
E
E
F
A
T
A
D
L
I
E
N
A
L
L
Y
T
L
E
E
G
R-
V
--
L
----
T
G
D
V
V
G
Y
D
R
G
----
A
K
---
T
T
E
Y
T
E
A
I
I
Q
N
L
G
K
T
P
R
---
K
T
Q
V
R
G
Y
K
P
F
R
L
P
Q
V
D
G
A
I
A
P
I
V
P
R
S
R
R
V
V
G
V
D
V
F
V
E
T
N
L-
L
P
E
A
L
G
K
A
L
E
D
L
A
A
----
G
T
P
F
R
L
K
M
I
S
N
R
G
T
Q
V
Y
P
PT
G
G
L
T
--
D
L
V
D
H
Y
R
C
R
F
L
Y
T
G
E
G
E
A
-
K
D
P
E
I
L
D
L
V
S
R
V
A
-
S
R
F
R
W
M
H
L
E
K
L
Q
E
F
D
G
E
P
G
F
T
K
-----
109
Fugue
91.68
38%
-78
- C5 -
2D1C
4
IDH_THET8
A:
[2-496]
P
L
I
T
T
ETG
K
K
M
H
V
L
ED
G
R
K
L
I
T
V
I
P
--
G
D
G
I
G
P
E
C
-------
V
E
A
T
L
K
V
L
E
--
A
A
-------
K
-------
A
P
----------
L
-----
A
Y
E
V
R
E
A
----
G
A
S
---
V
F
R
R
--
G
-
I
A
--
S
G
V
P
Q
E
T
-
I
E
S
I
R
-
K
T
R
V
V
L
K
G
P
L
E
------------------
T
P
V
G
--
Y
------
G
E
K
S
A
N
V
T
L
R
K
L
F
E
T
Y
A
N
V
R
P
V
R
E
F
-
P
--
N
V
P
T
-
P
Y
A
-----
G
---
R
--
G
-
I
D
L
V
V
V
R
E
N
V
E
D
L
Y
A
G
I
E
-----------
H
-----------------------
M
Q
----
T
-----------------------
P
-----------------------
S
V
-----
A
Q
T
L
---------
K
L
----------------------
I
-------------------------
S
W
K
G
S
E
K
I
V
R
F
A
F
E
L
A
R
A
------------
E
------------
G
R
K
K
V
H
C
A
T
K
S
N
I
M
K
L
A
E
G
T
L
--------------
K
R
-
A
F
---
E
Q
-
V
A
-
Q
----
E
Y
---------------
P
--------------------------------
D
--------------------------------
I
E
A
V
H
-----------
I
I
V
------
D
N
A
A
H
Q
L
V
K
R
P
E
Q
F
E
--
V
I
V
T
T
N
M
N
G
D
I
L
S
D
L
-
T
S
G
L
I
-
G
G
L
G
F
A
P
S
A
N
I
G
N
--
E
--
V
A
I
F
E
A
V
H
G
S
A
P
K
Y
A
G
K
N
V
I
N
P
T
A
-
V
L
L
S
A
V
M
M
L
R
Y
-
L
E
E
F
A
T
A
D
L
I
E
N
A
L
L
Y
T
L
E
E
G
R-
V
--
L
----
T
G
D
V
V
G
Y
D
R
G
----
A
---
K
T
T
E
Y
T
E
A
I
I
Q
N
L
G
K
T
P
R
K
T
Q
V
R
G
Y
K
P
F
R
L
P
Q
V
D
G
A
I
A
P
--
I
V
P
-
R
S
R
R
V
V
G
V
D
V
F
V
E
T
N
LL
P
E
A
L
G
K
A
L
E
D
L
A
A
G
----
T
P
F
-
R
L
K
M
I
S
N
R
G
T
Q
V
Y
P
PT
G
G
L
T
--
D
L
V
D
H
Y
R
C
R
F
L
Y
T
G
E
G
-
E
A
K
D
P
E
I
L
D
L
V
S
R
V
A
S
R
-
F
R
W
M
H
L
E
K
L
Q
E
F
D
G
E
P
G
F
T
K
A
QGED
103
HHSearch
81.20
33%
-82
- C5 -
1TYO
1
?
A:
[34-426]
----------------
D
N
P
V
V
A
F
I
R
--
G
D
G
V
G
P
E
V
-------
V
E
S
A
L
K
V
V
D
--
A
A
-------
V
K
K
VYGGS
R
R
----------
I
-----
V
W
W
E
L
L
A
----
G
H
L
---
A
R
E
K
----
C
G
--
E
L
L
P
K
A
T
-
L
E
G
I
R
-
L
A
R
V
A
L
K
G
P
L
E
------------------
T
P
V
G
--
T
------
G
Y
R
S
L
N
V
A
I
R
Q
A
L
D
L
Y
A
N
I
R
P
V
R
Y
Y
----
G
Q
-
P
-
A
-
P
HKY--
A
---
D
--
R
-
V
D
M
V
I
F
R
E
N
T
E
D
V
Y
A
G
I
E
-----------
W
-----------------------
P
H
----
D
S
P
E
A
A
R
I
R
R
F
L
A
E
E
FG
I
S
I
R
---
E
-----------------------
D
A
-----
G
I
G
V
---------
K
P
----------------------
I
-------------------------
S
R
F
A
T
R
R
L
M
E
R
A
L
E
W
A
L
R
------------
N
------------
G
N
T
V
V
T
I
M
H
K
G
N
I
M
K
Y
T
E
G
A
F
--------------
M
R
-
W
A
---
Y
E
-
V
A
L
E
----
K
F
REHVVT
E
Q
E
V
Q
E
KY-
G
GVRPEG--------------------------
K
--------------------------------
I
L
V
N
D
-----------
R
I
A
------
D
N
M
L
Q
Q
I
I
T
R
P
W
D
Y
Q
--
V
I
V
A
P
N
L
N
G
D
Y
I
S
D
A
-
A
S
A
L
V
-
G
G
I
G
M
A
A
G
M
N
M
G
D
--
G
--
I
A
V
A
E
P
V
H
G
T
A
P
K
Y
A
G
K
D
L
I
N
P
S
A
-
E
I
L
S
A
S
L
L
I
G
E
F
M
G
W
R
E
V
K
S
I
V
E
Y
A
I
R
K
A
V
Q
S
K
--
K
--
V
----
T
Q
D
L
A
R
H
M
P
G
----
V
Q
P
L
R
T
S
E
Y
T
E
T
L
I
A
Y
I
D
E
A
D
L
N
E
V
L
A
G
----------------------------------------------------------------------------------------------------------------------------------------------
100
HHSearch
79.76
37%
-81
- C5 -
2IV0
7
IDH_ARCFU
A:
[27-411]
-----------------
N
P
I
I
P
Y
F
E
--
G
D
G
I
G
K
D
V
-------
V
P
A
A
I
R
V
L
D
--
A
A
-------
A
D
K
I
G---
K
E
----------
V
-----
V
W
F
Q
V
Y
A
----
G
E
D
---
A
Y
K
L
----
Y
G
--
N
Y
L
P
D
D
T
-
L
N
A
I
K
-
E
F
R
V
A
L
K
G
P
L
T
------------------
T
P
V
G
--
G
------
G
Y
R
S
L
N
V
T
I
R
Q
V
L
D
L
Y
A
N
V
R
P
V
Y
Y
L
-
K
--
G
V
-
P
-
S
-
P
IKH--
P
---
E
--
K
-
V
N
F
V
I
F
R
E
N
T
E
D
V
Y
A
G
I
E
-----------
W
-----------------------
P
R
----
G
S
E
E
A
L
K
L
I
R
F
L
K
N
E
FGVTIR---
E
-----------------------
D
S
-----
G
I
G
I
---------
K
P
----------------------
I
-------------------------
S
E
F
A
T
K
R
L
V
R
M
A
I
R
Y
A
I
E
------------
N
------------
N
R
K
S
V
T
L
V
H
K
G
N
I
M
K
Y
T
E
G
A
F
--------------
R
D
-
W
G
---
Y
E
-
V
A
-
K
Q
---
E
F
---------------
G
EYCIT
E
D
E
L
W
D
K
YGGKQPEG------------
K
--------------------------------
I
V
V
K
D
-----------
R
I
A
------
D
N
M
F
Q
Q
I
L
T
R
T
D
E
Y
D
--
V
I
A
L
P
N
L
N
G
D
Y
L
S
D
A
-
A
A
A
L
I
-
G
G
L
G
I
A
P
G
S
N
I
G
D
--
G
--
I
G
V
F
E
P
V
H
G
S
A
P
K
Y
A
G
Q
N
K
V
N
P
T
A
-
E
I
L
T
G
A
L
M
F
E
Y
-
I
G
W
K
D
A
S
E
M
I
K
K
A
V
E
M
T
I
S
S
G
--
I
--
V
----
T
Y
D
I
H
R
H
M
-
G
----
G
T
K
V
G
T
R
E
F
A
E
A
V
V
E
N
L
Q
S
L
------------------------------------------------------------------------------------------------------------------------------------------------------
96
HHSearch
78.45
33%
-75
- C5 -
2D4V
4
?
A:
[25-429]
----------------
D
Q
P
I
I
P
F
I
E
--
G
D
G
I
G
C
D
V
-------
T
P
A
M
R
S
V
V
D
--
A
A
-------
V
A
K
V
YGGQ
R
Q
----------
I
-----
A
W
M
E
L
F
A
----
G
Q
K
---
A
V
Q
L
--
Y
G
E
G
--
Q
Y
L
P
D
E
T
-
M
A
A
I
R
-
E
Y
K
V
A
I
K
G
P
L
E
------------------
T
P
V
G
--
G
------
G
I
R
S
L
N
V
A
M
R
Q
D
L
D
L
Y
V
C
L
R
P
V
R
Y
F
-
E
--
G
T
-
P
-
S
-
P
MRH--
P
---
E
--
K
-
V
D
M
V
I
F
R
E
N
S
E
D
I
Y
A
G
I
E
-----------
W
-----------------------
P
A
----
G
S
P
E
A
E
K
I
I
R
F
L
R
EEMGVTKIRFP
D
-----------------------
S
S
-----
A
I
G
I
---------
K
P
----------------------
V
-------------------------
S
T
E
G
S
E
R
L
I
R
R
T
I
Q
Y
A
L
E
------------
H
------------
G
K
P
S
V
S
L
V
H
K
G
N
I
M
K
F
T
E
G
G
F
--------------
R
D
-
W
G
---
Y
A
-
L
A
E
R
----
E
F
---------------
A
GRVFT
W
R
Q
K
A
A
I
S
K
A
EG
K
A
A
G
Q
K
A
E
Q
Q
A
I
A
D
G
K
--------------------------------
L
I
I
K
D
-----------
V
I
A
------
D
N
F
L
Q
Q
I
L
L
R
P
E
D
Y
S
--
V
V
A
T
L
N
L
N
G
D
Y
V
S
D
A
-
L
A
A
E
V
-
G
G
I
G
M
A
P
G
A
N
L
S
D
--
T
--
H
A
I
F
E
A
T
H
G
T
A
P
D
I
A
G
Q
G
K
A
N
P
S
S
-
L
I
L
S
A
V
M
M
L
E
H
-
L
G
W
G
E
A
A
Q
A
I
V
A
A
M
N
A
T
I
A
A
G
--
E
--
V
----
T
G
D
L
A
A
L
R
G
D
----
V
P
A
L
S
T
T
E
F
T
A
A
L
I
R
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------
108
HHSearch
75.31
36%
-78
- C5 -
1HQS
7
IDH_BACSU
A:
[18-423]
----------------
N
N
P
I
I
P
F
I
E
--
G
D
G
T
G
P
D
I
-------
W
N
A
A
S
K
V
L
E
--
A
A
-------
V
E
K
A
Y
K
GE
K
K
----------
I
-----
T
W
K
E
V
Y
A
----
G
E
K
---
A
Y
N
K
----
T
G
--
E
W
L
P
A
E
T
-
L
D
V
I
R
-
E
Y
F
I
A
I
K
G
P
L
T
------------------
T
P
V
G
--
G
------
G
I
R
S
L
N
V
A
L
R
Q
E
L
D
L
F
V
C
L
R
P
V
R
Y
F
-
T
--
G
V
-
P
-
S
-
P
VKR--
P
---
E
--
D
-
T
D
M
V
I
F
R
E
N
T
E
D
I
Y
A
G
I
E
-----------
Y
-----------------------
A
K
----
G
-----------------------
S
E
E
V
Q
K
L
I
S
F
L
Q
NELNVNKIRFP
E
T
S
-----
G
I
G
I
---------
K
P
----------------------
V
-------------------------
S
E
E
G
T
S
R
L
V
R
A
A
I
D
Y
A
I
E
------------
H
------------
G
R
K
S
V
T
L
V
H
K
G
N
I
M
K
F
T
E
G
A
F
--------------
K
N
-
W
G
---
Y
E
-
L
A
E
K
----
E
Y
---------------
G
--------------------------------
D
KVF
T
W
A
Q
Y
D
R
I
A
E
EQ
G
K
D
A
A
N
K
A
Q
S
E
A
E
A
A
G
K
I
I
I
K
D
-----------
S
I
A
------
D
I
F
L
Q
Q
I
L
T
R
P
N
E
F
D
--
V
V
A
T
M
N
L
N
G
D
Y
I
S
D
A
-
L
A
A
Q
V
-
G
G
I
G
I
A
P
G
A
N
I
N
Y
ET
G
--
H
A
I
F
E
A
T
H
G
T
A
P
K
Y
A
G
L
D
K
V
N
P
S
S
-
V
I
L
S
G
V
L
L
L
E
H
-
L
G
W
N
E
A
A
D
L
V
I
K
S
M
E
K
T
I
A
S
K
--
V
--
V
----
T
Y
D
F
A
R
L
M
D
G
----
A
T
E
V
K
C
S
E
F
G
E
E
L
I
K
N
M
D
--------------------------------------------------------------------------------------------------------------------------------------------------------
97
HHSearch
75.29
35%
-85
- C5 -
3TY4
5
LYS12_SCHPO
A:
[9-364]
----------------
R
R
I
V
L
G
L
I
P
--
A
D
G
I
G
K
E
V
-------
V
P
A
A
R
R
L
M
E
--
N
L
-------
P
AKHK---
L
K
----------
F
-----
D
F
I
D
L
D
A
----
G
W
G
---
T
F
E
R
----
T
G
--
K
A
L
P
E
R
T
-
V
E
R
L
K
T
E
C
N
A
A
L
F
G
A
V
Q
------------------
S
P
T
H
KV
A
------
G
Y
S
S
P
I
V
A
L
R
K
K
M
G
L
Y
A
N
V
R
P
V
K
S
L
-
D
--
G
A
-
K
---------
G
---
K
--
P
-
V
D
L
V
I
V
R
E
N
T
E
C
L
Y
V
K
E
E
-----------
R
-----------------------
M
V
QNTP
G
-----------------------
K
-----------------------
R
V
-----
A
E
A
I
---------
R
R
----------------------
I
-------------------------
S
E
E
A
S
T
K
I
G
K
M
A
F
E
I
A
K
S
------------
R
Q
K
I
R
E
S
GTYSIH
K
K
P
L
V
T
I
I
H
K
S
N
V
M
S
V
T
D
G
L
F
--------------
R
E
-
S
C
---
R
H
-
A
Q
-
S
LDP-
S
Y
---------------
A
--------------------------------
S
--------------------------------
I
N
V
D
E
-----------
Q
I
V
------
D
S
M
V
Y
R
L
F
R
E
P
E
C
F
D
--
V
V
V
A
P
N
L
Y
G
D
I
L
S
D
G
-
A
A
S
L
I
-
G
S
L
G
L
V
P
S
A
N
V
G
D
--
N
--
F
V
M
S
E
P
V
H
G
S
A
P
D
I
A
G
R
G
I
A
N
P
V
A
-
T
F
R
S
V
A
L
M
L
E
F
-
M
G
H
Q
D
A
A
A
D
I
Y
T
A
V
D
K
V
L
T
E
G
K-
V
--
L
----
T
P
D
L
G
G
K
----------
S
G
T
N
E
I
T
D
A
V
L
A
N
I
---------------------------------------------------------------------------------------------------------------------------------------------------------
89
HHSearch
74.69
40%
-86
- C5 -
3BLX
-
IDH2_YEAST
B:
[21-354]
-----------------
K
Y
T
V
S
F
I
E
--
G
D
G
I
G
P
E
I
-------
S
K
S
V
K
K
I
F
S
--
A
A
-------
N
-------
V
P
----------
I
-----
E
W
E
S
C
D
V
----
S
P
I
----
F
V
N
----
G
L
--
T
T
I
P
D
P
A
-
V
Q
S
I
T
-
K
N
L
V
A
L
K
G
P
L
A
------------------
T
P
------------
H
R
S
L
N
L
T
L
R
K
T
F
G
L
F
A
N
V
R
P
A
K
S
I
-
E
--
G
F
-
K
-
T
-
T
-----
Y
---
E
--
N
-
V
D
L
V
L
I
R
E
N
T
E
G
E
Y
S
G
I
E
-----------
H
-----------------------
I
V
----
C
-----------------------
P
-----------------------
G
V
-----
V
Q
S
I
---------
K
L
----------------------
I
-------------------------
T
R
D
A
S
E
R
V
I
R
Y
A
F
E
Y
A
R
A
------------
I
------------
G
R
P
R
V
I
V
V
H
K
S
T
I
Q
R
L
A
D
G
L
F
--------------
V
N
-
V
A
---
K
E
-
L
S
-
K
----
E
Y
---------------
P
--------------------------------
D
--------------------------------
L
T
L
E
T
-----------
E
L
I
------
D
N
S
V
L
K
V
V
T
N
P
S
A
Y
T
D
A
V
S
V
C
P
N
L
Y
G
D
I
L
S
D
L
-
N
S
G
L
S
A
G
S
L
G
L
T
P
S
A
N
I
G
H
--
K
--
I
S
I
F
E
A
V
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
T
A
-
L
L
L
S
S
V
M
M
L
N
H
-
M
G
L
T
N
H
A
D
Q
I
Q
N
A
V
L
S
T
I
A
S
G
PE
N
--
R
----
T
G
D
L
A
G
T
----------
A
T
T
S
S
F
T
E
A
V
I
K
R
L
---------------------------------------------------------------------------------------------------------------------------------------------------------
88
HHSearch
74.40
35%
-85
- C5 -
1X0L
-
HICDH_THET2
A:
[2-333]
-----------------
A
Y
R
I
C
L
I
E
--
G
D
G
I
G
H
E
V
-------
I
P
A
A
R
R
V
L
E
--
A
T
-------
G
-------
L
P
----------
L
-----
E
F
V
E
A
E
A
----
G
W
E
---
T
F
E
R
----
R
G
--
T
S
V
P
E
E
T
-
V
E
K
I
L
-
S
C
H
A
T
L
F
G
A
A
T
------------------
S
P
T
R
KV
P
------
G
F
F
G
A
I
R
Y
L
R
R
R
L
D
L
Y
A
N
V
R
P
A
K
S
R
-
P
--
V
P
---
G
-
S
-----
R
---
P
--
G
-
V
D
L
V
I
V
R
E
N
T
E
G
L
Y
V
E
Q
E
-----------
R
-----------------------
R
Y
----------------------------
L
-----------------------
D
V
-----
A
I
A
D
---------
A
V
----------------------
I
-------------------------
S
K
K
A
S
E
R
I
G
R
A
A
L
R
I
A
E
G
------------
R
------------
P
R
K
T
L
H
I
A
H
K
A
N
V
L
P
L
T
Q
G
L
F
--------------
L
D
-
T
V
---
K
E
-
V
A
-
K
----
D
F
---------------
P
--------------------------------
L
--------------------------------
V
N
V
Q
D
-----------
I
I
V
------
D
N
C
A
M
Q
L
V
M
R
P
E
R
F
D
--
V
I
V
T
T
N
L
L
G
D
I
L
S
D
L
-
A
A
G
L
V
-
G
G
L
G
L
A
P
S
G
N
I
G
D
--
T
--
T
A
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
-
A
I
L
S
A
A
M
M
L
D
Y
-
L
G
E
K
E
A
A
K
R
V
E
K
A
V
D
L
V
L
E
R
G
--
P
--
R
----
T
P
D
L
G
G
D
----------
A
T
T
E
A
F
T
E
A
V
V
E
A
L
K
S
L
------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
74.14
35%
-79
- C5 -
2IV0
8
IDH_ARCFU
B:
[35-409]
---------------------------
G
D
G
I
G
K
D
V
-------
V
P
A
A
I
R
V
L
D
--
A
A
-------
A
-------
D
K
----------
I
-----
G
K
E
V
V
W
F
QVYA
G
E
D
---
A
Y
K
L
--
Y
-
G
N
--
Y
-
L
P
D
D
T
-
L
N
A
I
K
-
E
F
R
V
A
L
K
G
P
L
T
------------------
T
P
V
G
--
G
------
G
Y
R
S
L
N
V
T
I
R
Q
V
L
D
L
Y
A
N
V
R
P
V
Y
Y
L
-
K
GV
P
S
P
I
-
K
-
H
-----
P
---
E
--
K
-
V
N
F
V
I
F
R
E
N
T
E
D
V
Y
A
G
I
E
-----------
W
PRGSEEALKLI------------
R
F
----
L
-----------------------
K
-----------------------
N
E
-----
F
G
V
T
IREDSGIGI
K
P
----------------------
I
-------------------------
S
E
F
A
T
K
R
L
V
R
M
A
I
R
Y
A
I
E
------------
N
------------
N
R
K
S
V
T
L
V
H
K
G
N
I
M
K
Y
T
E
G
A
F
--------------
R
D
-
W
G
---
Y
E
-
V
A
-
K
QEFG
E
Y
CITEDELWDKYGGKQ
P
--------------------------------
E
GK------------------------------
I
V
V
K
D
-----------
R
I
A
------
D
N
M
F
Q
Q
I
L
T
R
T
D
E
Y
D
--
V
I
A
L
P
N
L
N
G
D
Y
L
S
D
A
-
A
A
A
L
I
-
G
G
L
G
I
A
P
G
S
N
I
G
D
--
G
--
I
G
V
F
E
P
V
H
G
S
A
P
K
Y
A
G
Q
N
K
V
N
P
T
A
-
E
I
L
T
G
A
L
M
F
E
Y
-
I
G
W
K
D
A
S
E
M
I
K
K
A
V
E
M
T
I
S
S
G
--
I
--
V
----
T
Y
D
I
H
R
H
-
M
G
----
G
T
K
V
G
T
R
E
F
A
E
A
V
V
E
N
L
Q
S
L
------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
72.98
39%
-86
- C5 -
3BLW
2
IDH2_YEAST
B:
[23-354]
---------------------
T
V
S
F
IE
G
D
G
I
G
P
E
I
-------
S
K
S
V
K
K
I
F
S
--
A
A
-------
N
-------
V
P
----------
I
-----
E
W
E
S
C
D
V
----
S
P
I
---
F
V
N
G
--
L
-
T
T
----
I
P
D
P
A
-
V
Q
S
I
T
-
K
N
L
V
A
L
K
G
P
L
A
------------------
T
P
------------
H
R
S
L
N
L
T
L
R
K
T
F
G
L
F
A
N
V
R
P
A
K
S
I
-
E
--
G
-
F
K
-
T
-
T
-----
Y
---
E
--
N
-
V
D
L
V
L
I
R
E
N
T
E
G
E
Y
S
G
I
E
-----------
H
-----------------------
I
V
----
C
-----------------------
P
-----------------------
G
V
-----
V
Q
S
I
---------
K
L
----------------------
I
-------------------------
T
R
D
A
S
E
R
V
I
R
Y
A
F
E
Y
A
R
A
------------
I
------------
G
R
P
R
V
I
V
V
H
K
S
T
I
Q
R
L
A
D
G
L
F
--------------
V
N
-
V
A
---
K
E
-
L
S
-
K
----
E
Y
---------------
P
--------------------------------
D
--------------------------------
L
T
L
E
T
-----------
E
L
I
------
D
N
S
V
L
K
V
V
T
N
P
S
A
Y
T
DA
V
S
V
C
P
N
L
Y
G
D
I
L
S
D
L
N
S
G
L
S
A
-
G
S
L
G
L
T
P
S
A
N
I
G
H
--
K
--
I
S
I
F
E
A
V
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
T
A
-
L
L
L
S
S
V
M
M
L
N
H
-
M
G
L
T
N
H
A
D
Q
I
Q
N
A
V
L
S
T
I
A
S
G
--
P
EN
R
----
T
G
D
L
A
G
T
A
T
----------
T
S
S
F
T
E
A
V
I
K
R
L
---------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
72.90
39%
-87
- C5 -
3BLW
1
IDH2_YEAST
N:
[23-354]
---------------------
T
V
S
F
IE
G
D
G
I
G
P
E
I
-------
S
K
S
V
K
K
I
F
S
--
A
A
-------
N
-------
V
P
----------
I
-----
E
W
E
S
C
D
V
----
S
P
I
---
F
V
N
G
--
L
-
T
T
----
I
P
D
P
A
-
V
Q
S
I
T
-
K
N
L
V
A
L
K
G
P
L
A
------------------
T
P
------------
H
R
S
L
N
L
T
L
R
K
T
F
G
L
F
A
N
V
R
P
A
K
S
I
-
E
--
G
-
F
K
-
T
-
T
-----
Y
---
E
--
N
-
V
D
L
V
L
I
R
E
N
T
E
G
E
Y
S
G
I
E
-----------
H
-----------------------
I
V
----
C
-----------------------
P
-----------------------
G
V
-----
V
Q
S
I
---------
K
L
----------------------
I
-------------------------
T
R
D
A
S
E
R
V
I
R
Y
A
F
E
Y
A
R
A
------------
I
------------
G
R
P
R
V
I
V
V
H
K
S
T
I
Q
R
L
A
D
G
L
F
--------------
V
N
-
V
A
---
K
E
-
L
S
-
K
----
E
Y
---------------
P
--------------------------------
D
--------------------------------
L
T
L
E
T
-----------
E
L
I
------
D
N
S
V
L
K
V
V
T
N
P
S
A
Y
T
DA
V
S
V
C
P
N
L
Y
G
D
I
L
S
D
L
N
S
G
L
S
A
-
G
S
L
G
L
T
P
S
A
N
I
G
H
--
K
--
I
S
I
F
E
A
V
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
T
A
-
L
L
L
S
S
V
M
M
L
N
H
-
M
G
L
T
N
H
A
D
Q
I
Q
N
A
V
L
S
T
I
A
S
G
--
P
EN
R
----
T
G
D
L
A
G
T
A
T
----------
T
S
S
F
T
E
A
V
I
K
R
L
---------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
72.88
39%
-86
- C5 -
3BLW
1
IDH2_YEAST
J:
[23-354]
---------------------
T
V
S
F
IE
G
D
G
I
G
P
E
I
-------
S
K
S
V
K
K
I
F
S
--
A
A
-------
N
-------
V
P
----------
I
-----
E
W
E
S
C
D
V
----
S
P
I
---
F
V
N
G
--
L
-
T
T
----
I
P
D
P
A
-
V
Q
S
I
T
-
K
N
L
V
A
L
K
G
P
L
A
------------------
T
P
------------
H
R
S
L
N
L
T
L
R
K
T
F
G
L
F
A
N
V
R
P
A
K
S
I
-
E
--
G
-
F
K
-
T
-
T
-----
Y
---
E
--
N
-
V
D
L
V
L
I
R
E
N
T
E
G
E
Y
S
G
I
E
-----------
H
-----------------------
I
V
----
C
-----------------------
P
-----------------------
G
V
-----
V
Q
S
I
---------
K
L
----------------------
I
-------------------------
T
R
D
A
S
E
R
V
I
R
Y
A
F
E
Y
A
R
A
------------
I
------------
G
R
P
R
V
I
V
V
H
K
S
T
I
Q
R
L
A
D
G
L
F
--------------
V
N
-
V
A
---
K
E
-
L
S
-
K
----
E
Y
---------------
P
--------------------------------
D
--------------------------------
L
T
L
E
T
-----------
E
L
I
------
D
N
S
V
L
K
V
V
T
N
P
S
A
Y
T
DA
V
S
V
C
P
N
L
Y
G
D
I
L
S
D
L
N
S
G
L
S
A
-
G
S
L
G
L
T
P
S
A
N
I
G
H
--
K
--
I
S
I
F
E
A
V
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
T
A
-
L
L
L
S
S
V
M
M
L
N
H
-
M
G
L
T
N
H
A
D
Q
I
Q
N
A
V
L
S
T
I
A
S
G
--
P
EN
R
----
T
G
D
L
A
G
T
A
T
----------
T
S
S
F
T
E
A
V
I
K
R
L
---------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
72.70
39%
-87
- C5 -
3BLW
1
IDH2_YEAST
L:
[23-354]
---------------------
T
V
S
F
IE
G
D
G
I
G
P
E
I
-------
S
K
S
V
K
K
I
F
S
--
A
A
-------
N
-------
V
P
----------
I
-----
E
W
E
S
C
D
V
----
S
P
I
---
F
V
N
G
--
L
-
T
T
----
I
P
D
P
A
-
V
Q
S
I
T
-
K
N
L
V
A
L
K
G
P
L
A
------------------
T
P
------------
H
R
S
L
N
L
T
L
R
K
T
F
G
L
F
A
N
V
R
P
A
K
S
I
-
E
--
G
-
F
K
-
T
-
T
-----
Y
---
E
--
N
-
V
D
L
V
L
I
R
E
N
T
E
G
E
Y
S
G
I
E
-----------
H
-----------------------
I
V
----
C
-----------------------
P
-----------------------
G
V
-----
V
Q
S
I
---------
K
L
----------------------
I
-------------------------
T
R
D
A
S
E
R
V
I
R
Y
A
F
E
Y
A
R
A
------------
I
------------
G
R
P
R
V
I
V
V
H
K
S
T
I
Q
R
L
A
D
G
L
F
--------------
V
N
-
V
A
---
K
E
-
L
S
-
K
----
E
Y
---------------
P
--------------------------------
D
--------------------------------
L
T
L
E
T
-----------
E
L
I
------
D
N
S
V
L
K
V
V
T
N
P
S
A
Y
T
DA
V
S
V
C
P
N
L
Y
G
D
I
L
S
D
L
N
S
G
L
S
A
-
G
S
L
G
L
T
P
S
A
N
I
G
H
--
K
--
I
S
I
F
E
A
V
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
T
A
-
L
L
L
S
S
V
M
M
L
N
H
-
M
G
L
T
N
H
A
D
Q
I
Q
N
A
V
L
S
T
I
A
S
G
--
P
EN
R
----
T
G
D
L
A
G
T
A
T
----------
T
S
S
F
T
E
A
V
I
K
R
L
---------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
72.70
39%
-87
- C5 -
3BLW
7
IDH2_YEAST
P:
[23-354]
---------------------
T
V
S
F
IE
G
D
G
I
G
P
E
I
-------
S
K
S
V
K
K
I
F
S
--
A
A
-------
N
-------
V
P
----------
I
-----
E
W
E
S
C
D
V
----
S
P
I
---
F
V
N
G
--
L
-
T
T
----
I
P
D
P
A
-
V
Q
S
I
T
-
K
N
L
V
A
L
K
G
P
L
A
------------------
T
P
------------
H
R
S
L
N
L
T
L
R
K
T
F
G
L
F
A
N
V
R
P
A
K
S
I
-
E
--
G
-
F
K
-
T
-
T
-----
Y
---
E
--
N
-
V
D
L
V
L
I
R
E
N
T
E
G
E
Y
S
G
I
E
-----------
H
-----------------------
I
V
----
C
-----------------------
P
-----------------------
G
V
-----
V
Q
S
I
---------
K
L
----------------------
I
-------------------------
T
R
D
A
S
E
R
V
I
R
Y
A
F
E
Y
A
R
A
------------
I
------------
G
R
P
R
V
I
V
V
H
K
S
T
I
Q
R
L
A
D
G
L
F
--------------
V
N
-
V
A
---
K
E
-
L
S
-
K
----
E
Y
---------------
P
--------------------------------
D
--------------------------------
L
T
L
E
T
-----------
E
L
I
------
D
N
S
V
L
K
V
V
T
N
P
S
A
Y
T
DA
V
S
V
C
P
N
L
Y
G
D
I
L
S
D
L
N
S
G
L
S
A
-
G
S
L
G
L
T
P
S
A
N
I
G
H
--
K
--
I
S
I
F
E
A
V
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
T
A
-
L
L
L
S
S
V
M
M
L
N
H
-
M
G
L
T
N
H
A
D
Q
I
Q
N
A
V
L
S
T
I
A
S
G
--
P
EN
R
----
T
G
D
L
A
G
T
A
T
----------
T
S
S
F
T
E
A
V
I
K
R
L
---------------------------------------------------------------------------------------------------------------------------------------------------------
101
HHSearch
72.69
33%
-75
- C5 -
3DMS
-
?
A:
[27-419]
----------------
D
Q
P
I
I
P
Y
I
E
--
G
D
G
T
G
F
D
I
-------
T
P
V
M
I
K
V
V
D
--
A
A
-------
V
E
K
A
Y
GGK
K
K
----------
I
-----
H
W
M
E
I
Y
A
----
G
E
K
---
A
T
K
V
----
Y
G
PD
V
W
L
P
E
E
T
-
L
Q
V
L
K
-
E
Y
V
V
S
I
K
G
P
L
T
------------------
T
P
V
------------
R
S
L
N
V
A
L
R
Q
E
L
D
L
Y
V
C
L
R
P
I
Q
Y
F
-
K
--
G
V
-
P
-
S
-
P
VRE--
P
---
E
--
K
-
T
N
M
V
I
F
R
E
N
S
E
D
I
Y
A
G
I
E
-----------
W
-----------------------
A
A
----
E
S
E
Q
A
K
K
V
I
K
F
L
Q
E
EMGVKKIRFP
Q
-----------------------
T
S
-----
G
I
G
I
---------
K
P
----------------------
V
-------------------------
S
K
E
G
T
E
R
L
V
R
K
A
I
Q
Y
A
I
D
------------
N
------------
D
R
K
S
V
T
L
V
H
K
G
N
I
M
K
F
T
E
G
A
F
--------------
R
D
-
A
G
---
Y
A
-
L
A
Q
K
----
E
F
G
A
E
L
I
DGGP
W
M
K
F
K
N
P
KTG
N
----------------------------
E
--------------------------------
I
V
V
K
D
-----------
S
I
A
------
D
A
F
L
Q
Q
I
L
L
R
P
A
E
Y
D
--
V
I
A
T
L
N
L
N
G
D
Y
I
S
D
A
-
L
A
A
Q
V
-
G
G
I
G
I
A
P
G
A
N
L
S
D
--
S
--
V
A
M
F
E
A
T
H
G
T
A
P
K
Y
A
G
K
D
Y
V
N
P
G
S
-
E
I
L
S
A
E
M
M
L
R
H
-
L
G
W
T
E
A
A
D
V
I
I
S
A
M
E
K
S
I
K
Q
K
--
R
--
V
----
T
Y
D
F
A
R
L
M
E
G
----
A
T
Q
V
S
C
S
G
F
G
Q
V
L
I
E
N
M
E
--------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
72.64
39%
-86
- C5 -
3BLW
1
IDH2_YEAST
F:
[23-354]
---------------------
T
V
S
F
IE
G
D
G
I
G
P
E
I
-------
S
K
S
V
K
K
I
F
S
--
A
A
-------
N
-------
V
P
----------
I
-----
E
W
E
S
C
D
V
----
S
P
I
---
F
V
N
G
--
L
-
T
T
----
I
P
D
P
A
-
V
Q
S
I
T
-
K
N
L
V
A
L
K
G
P
L
A
------------------
T
P
------------
H
R
S
L
N
L
T
L
R
K
T
F
G
L
F
A
N
V
R
P
A
K
S
I
-
E
--
G
-
F
K
-
T
-
T
-----
Y
---
E
--
N
-
V
D
L
V
L
I
R
E
N
T
E
G
E
Y
S
G
I
E
-----------
H
-----------------------
I
V
----
C
-----------------------
P
-----------------------
G
V
-----
V
Q
S
I
---------
K
L
----------------------
I
-------------------------
T
R
D
A
S
E
R
V
I
R
Y
A
F
E
Y
A
R
A
------------
I
------------
G
R
P
R
V
I
V
V
H
K
S
T
I
Q
R
L
A
D
G
L
F
--------------
V
N
-
V
A
---
K
E
-
L
S
-
K
----
E
Y
---------------
P
--------------------------------
D
--------------------------------
L
T
L
E
T
-----------
E
L
I
------
D
N
S
V
L
K
V
V
T
N
P
S
A
Y
T
DA
V
S
V
C
P
N
L
Y
G
D
I
L
S
D
L
N
S
G
L
S
A
-
G
S
L
G
L
T
P
S
A
N
I
G
H
--
K
--
I
S
I
F
E
A
V
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
T
A
-
L
L
L
S
S
V
M
M
L
N
H
-
M
G
L
T
N
H
A
D
Q
I
Q
N
A
V
L
S
T
I
A
S
G
--
P
EN
R
----
T
G
D
L
A
G
T
A
T
----------
T
S
S
F
T
E
A
V
I
K
R
L
---------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
72.60
39%
-87
- C5 -
3BLW
2
IDH2_YEAST
D:
[23-354]
---------------------
T
V
S
F
IE
G
D
G
I
G
P
E
I
-------
S
K
S
V
K
K
I
F
S
--
A
A
-------
N
-------
V
P
----------
I
-----
E
W
E
S
C
D
V
----
S
P
I
---
F
V
N
G
--
L
-
T
T
----
I
P
D
P
A
-
V
Q
S
I
T
-
K
N
L
V
A
L
K
G
P
L
A
------------------
T
P
------------
H
R
S
L
N
L
T
L
R
K
T
F
G
L
F
A
N
V
R
P
A
K
S
I
-
E
--
G
-
F
K
-
T
-
T
-----
Y
---
E
--
N
-
V
D
L
V
L
I
R
E
N
T
E
G
E
Y
S
G
I
E
-----------
H
-----------------------
I
V
----
C
-----------------------
P
-----------------------
G
V
-----
V
Q
S
I
---------
K
L
----------------------
I
-------------------------
T
R
D
A
S
E
R
V
I
R
Y
A
F
E
Y
A
R
A
------------
I
------------
G
R
P
R
V
I
V
V
H
K
S
T
I
Q
R
L
A
D
G
L
F
--------------
V
N
-
V
A
---
K
E
-
L
S
-
K
----
E
Y
---------------
P
--------------------------------
D
--------------------------------
L
T
L
E
T
-----------
E
L
I
------
D
N
S
V
L
K
V
V
T
N
P
S
A
Y
T
DA
V
S
V
C
P
N
L
Y
G
D
I
L
S
D
L
N
S
G
L
S
A
-
G
S
L
G
L
T
P
S
A
N
I
G
H
--
K
--
I
S
I
F
E
A
V
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
T
A
-
L
L
L
S
S
V
M
M
L
N
H
-
M
G
L
T
N
H
A
D
Q
I
Q
N
A
V
L
S
T
I
A
S
G
--
P
EN
R
----
T
G
D
L
A
G
T
A
T
----------
T
S
S
F
T
E
A
V
I
K
R
L
---------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
72.01
31%
-77
- C5 -
1P8F
6
IDH_ECOLI
A:
[34-416]
---------------------------
G
D
G
I
G
V
D
V
-------
T
P
A
M
L
K
V
V
D
--
A
A
V
E
K
A
Y
K
G
E
-------
R
K
----------
I
-----
S
W
M
E
I
Y
T
----
G
E
K
S
T
Q
V
Y
G
Q
--
D
V
W
-----
L
P
A
E
T
-
L
D
L
I
R
-
E
Y
R
V
A
I
K
G
P
L
T
------------------
T
P
V
G
--
G
------
G
I
R
S
L
N
V
A
L
R
Q
E
L
D
L
Y
I
C
L
R
P
V
R
Y
Y
-
Q
GT
P
S
P
V
-
K
-
H
-----
P
---
E
--
L
-
T
D
M
V
I
F
R
E
N
S
E
D
I
Y
A
G
I
E
-----------
W
-----------------------
K
-----------------------------
A
-----------------------
D
S
-----
A
D
A
E
---------
K
V
----------------------
I
K
F
L
R
E
EMGVKKIRFPEH
C
G
I
G
I
K
P
C
S
E
E
G
T
K
R
L
V
R
A
A
I
E
Y
A
I
A
------------
N
------------
D
R
D
S
V
T
L
V
H
K
G
N
I
M
K
F
T
E
G
A
F
--------------
K
D
-
W
G
---
Y
Q
-
L
A
-
R
----
E
E
FG
G
E
L
I
DGG------
P
--------------------------------
W
--------------------------------
L
K
V
K
N
PNTG
K
E
I
V
I
K
D
V
I
A
------
D
A
F
L
Q
Q
I
L
L
R
P
A
E
Y
D
--
V
I
A
C
M
N
L
N
G
D
Y
I
S
D
A
-
L
A
A
Q
V
-
G
G
I
G
I
A
P
G
A
N
I
G
D
--
E
--
C
A
L
F
E
A
T
H
G
T
A
P
K
Y
A
G
Q
D
K
V
N
P
G
S
-
I
I
L
S
A
E
M
M
L
R
H
-
M
G
W
T
E
A
A
D
L
I
----
V
K
G
M
E
G
A
--
I
--
N
A
KTV
T
Y
D
F
E
R
L
M
D
G
----
A
K
L
L
K
C
S
E
F
G
D
A
I
I
E
N
M
---------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
71.89
31%
-76
- C5 -
1CW7
3
IDH_ECOLI
A:
[34-416]
---------------------------
G
D
G
I
G
V
D
V
-------
T
P
A
M
L
K
V
V
D
--
A
A
V
E
K
A
Y
K
G
E
-------
R
K
----------
I
-----
S
W
M
E
I
Y
T
----
G
E
K
S
T
Q
V
Y
G
Q
--
D
V
W
-----
L
P
A
E
T
-
L
D
L
I
R
-
E
Y
R
V
A
I
K
G
P
L
T
------------------
T
P
V
G
--
G
------
G
I
R
S
L
N
V
A
L
R
Q
E
L
D
L
Y
I
C
L
R
P
V
R
Y
Y
-
Q
GT
P
S
P
V
-
K
-
H
-----
P
---
E
--
L
-
T
D
M
V
I
F
R
E
N
S
E
D
I
Y
A
G
I
E
-----------
W
-----------------------
K
-----------------------------
A
-----------------------
D
S
-----
A
D
A
E
---------
K
V
----------------------
I
K
F
L
R
E
EMGVKKIRFPEH
C
G
I
G
I
K
P
C
S
E
E
G
T
K
R
L
V
R
A
A
I
E
Y
A
I
A
------------
N
------------
D
R
D
S
V
T
L
V
H
K
G
N
I
M
K
F
T
E
G
A
F
--------------
K
D
-
W
G
---
Y
Q
-
L
A
-
R
----
E
E
FG
G
E
L
I
DGG------
P
--------------------------------
W
--------------------------------
L
K
V
K
N
PNTG
K
E
I
V
I
K
D
V
I
A
------
D
A
F
L
Q
Q
I
L
L
R
P
A
E
Y
D
--
V
I
A
C
M
N
L
N
G
D
Y
I
S
D
A
-
L
A
A
Q
V
-
G
G
I
G
I
A
P
G
A
N
I
G
D
--
E
--
C
A
L
F
E
A
T
H
G
T
A
P
A
Y
A
G
Q
D
K
V
N
P
G
S
-
I
I
L
S
A
E
M
M
L
R
H
-
M
G
W
T
E
A
A
D
L
I
----
V
K
G
M
E
G
A
--
I
--
N
A
KTV
T
Y
D
F
E
R
L
M
D
G
----
A
K
L
L
K
C
S
E
F
G
D
A
I
I
E
N
M
---------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
71.73
31%
-77
- C5 -
1AI2
2
IDH_ECOLI
A:
[34-416]
---------------------------
G
D
G
I
G
V
D
V
-------
T
P
A
M
L
K
V
V
D
--
A
A
V
E
K
A
Y
K
G
E
-------
R
K
----------
I
-----
S
W
M
E
I
Y
T
----
G
E
K
S
T
Q
V
Y
G
Q
--
D
V
W
-----
L
P
A
E
T
-
L
D
L
I
R
-
E
Y
R
V
A
I
K
G
P
L
T
------------------
T
P
V
G
--
G
------
G
I
R
S
L
N
V
A
L
R
Q
E
L
D
L
Y
I
C
L
R
P
V
R
Y
Y
-
Q
GT
P
S
P
V
-
K
-
H
-----
P
---
E
--
L
-
T
D
M
V
I
F
R
E
N
S
E
D
I
Y
A
G
I
E
-----------
W
-----------------------
K
-----------------------------
A
-----------------------
D
S
-----
A
D
A
E
---------
K
V
----------------------
I
K
F
L
R
E
EMGVKKIRFPEH
C
G
I
G
I
K
P
C
S
E
E
G
T
K
R
L
V
R
A
A
I
E
Y
A
I
A
------------
N
------------
D
R
D
S
V
T
L
V
H
K
G
N
I
M
K
F
T
E
G
A
F
--------------
K
D
-
W
G
---
Y
Q
-
L
A
-
R
----
E
E
FG
G
E
L
I
DGG------
P
--------------------------------
W
--------------------------------
L
K
V
K
N
PNTG
K
E
I
V
I
K
D
V
I
A
------
D
A
F
L
Q
Q
I
L
L
R
P
A
E
Y
D
--
V
I
A
C
M
N
L
N
G
D
Y
I
S
D
A
-
L
A
A
Q
V
-
G
G
I
G
I
A
P
G
A
N
I
G
D
--
E
--
C
A
L
F
E
A
T
H
G
T
A
P
K
Y
A
G
Q
D
K
V
N
P
G
S
-
I
I
L
S
A
E
M
M
L
R
H
-
M
G
W
T
E
A
A
D
L
I
----
V
K
G
M
E
G
A
--
I
--
N
A
KTV
T
Y
D
F
E
R
L
M
D
G
----
A
K
L
L
K
C
S
E
F
G
D
A
I
I
E
N
M
---------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
71.73
31%
-79
- C5 -
5ICD
2
IDH_ECOLI
A:
[34-416]
---------------------------
G
D
G
I
G
V
D
V
-------
T
P
A
M
L
K
V
V
D
--
A
A
V
E
K
A
YKG
E
-------
R
K
----------
I
-----
S
W
M
E
I
Y
T
----
G
E
K
S
T
Q
V
Y
G
Q
--
D
V
W
-----
L
P
A
E
T
-
L
D
L
I
R
-
E
Y
R
V
A
I
K
G
P
L
T
------------------
T
P
V
G
--
G
------
G
I
R
S
L
N
V
A
L
R
Q
E
L
D
L
Y
I
C
L
R
P
V
R
Y
Y
-
Q
GT
P
S
P
V
-
K
-
H
-----
P
---
E
--
L
-
T
D
M
V
I
F
R
E
N
S
E
D
I
Y
A
G
I
E
-----------
W
-----------------------
K
-----------------------------
A
-----------------------
D
S
-----
A
D
A
E
---------
K
V
----------------------
I
K
F
L
R
E
EMGVKKIRFPEH
C
G
I
G
I
K
P
C
S
E
E
G
T
K
R
L
V
R
A
A
I
E
Y
A
I
A
------------
N
------------
D
R
D
S
V
T
L
V
H
K
G
N
I
M
K
F
T
E
G
A
F
--------------
K
D
-
W
G
---
Y
Q
-
L
A
-
R
----
E
E
FG
G
E
L
IDGG------
P
--------------------------------
W
--------------------------------
L
K
V
K
N
PNTG
K
E
I
V
I
K
D
V
I
A
------
D
A
F
L
Q
Q
I
L
L
R
P
A
E
Y
D
--
V
I
A
C
M
N
L
N
G
D
Y
I
S
D
A
-
L
A
A
Q
V
-
G
G
I
G
I
A
P
G
A
N
I
G
D
--
E
--
C
A
L
F
E
A
T
H
G
T
A
P
K
Y
A
G
Q
D
K
V
N
P
G
S
-
I
I
L
S
A
E
M
M
L
R
H
-
M
G
W
T
E
A
A
D
L
I
----
V
K
G
M
E
G
A
--
I
--
N
A
KTV
T
Y
D
F
E
R
L
M
D
G
----
A
K
L
L
K
C
S
E
F
G
D
A
I
I
E
N
M
---------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
71.64
31%
-76
- C5 -
1PB1
5
IDH_ECOLI
A:
[34-416]
---------------------------
G
D
G
I
G
V
D
V
-------
T
P
A
M
L
K
V
V
D
--
A
A
V
E
K
A
Y
K
G
E
-------
R
K
----------
I
-----
S
W
M
E
I
Y
T
----
G
E
K
S
T
Q
V
Y
G
Q
--
D
V
W
-----
L
P
A
E
T
-
L
D
L
I
R
-
E
Y
R
V
A
I
K
G
P
L
T
------------------
T
P
V
G
--
G
------
G
I
R
S
L
N
V
A
L
R
Q
E
L
D
L
Y
I
C
L
R
P
V
R
Y
Y
-
Q
GT
P
S
P
V
-
K
-
H
-----
P
---
E
--
L
-
T
D
M
V
I
F
R
E
N
S
E
D
I
Y
A
G
I
E
-----------
W
-----------------------
K
-----------------------------
A
-----------------------
D
S
-----
A
D
A
E
---------
K
V
----------------------
I
K
F
L
R
E
EMGVKKIRFPEH
C
G
I
G
I
K
P
C
S
E
E
G
T
K
R
L
V
R
A
A
I
E
Y
A
I
A
------------
N
------------
D
R
D
S
V
T
L
V
H
K
G
N
I
M
K
F
T
E
G
A
F
--------------
K
D
-
W
G
---
Y
Q
-
L
A
-
R
----
E
E
FG
G
E
L
I
DGG------
P
--------------------------------
W
--------------------------------
L
K
V
K
N
PNTG
K
E
I
V
I
K
D
V
I
A
------
D
A
F
L
Q
Q
I
L
L
R
P
A
E
Y
D
--
V
I
A
C
M
N
L
N
G
D
Y
I
S
D
A
-
L
A
A
Q
V
-
G
G
I
G
I
A
P
G
A
N
I
G
D
--
E
--
C
A
L
F
E
A
T
H
G
T
A
P
K
Y
A
G
Q
D
K
V
N
P
G
S
-
I
I
L
S
A
E
M
M
L
R
H
-
M
G
W
T
E
A
A
D
L
I
----
V
K
G
M
E
G
A
--
I
--
N
A
KTV
T
Y
D
F
E
R
L
M
D
G
----
A
K
L
L
K
C
S
E
F
G
D
A
I
I
E
N
M
---------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
70.82
31%
-76
- C5 -
1AI3
3
IDH_ECOLI
A:
[34-416]
---------------------------
G
D
G
I
G
V
D
V
-------
T
P
A
M
L
K
V
V
D
--
A
A
V
E
K
A
Y
KG
E
-------
R
K
----------
I
-----
S
W
M
E
I
Y
T
----
G
E
K
S
T
Q
V
Y
G
Q
--
D
V
W
-----
L
P
A
E
T
-
L
D
L
I
R
-
E
Y
R
V
A
I
K
G
P
L
T
------------------
T
P
V
G
--
G
------
G
I
R
S
L
N
V
A
L
R
Q
E
L
D
L
Y
I
C
L
R
P
V
R
Y
Y
-
Q
GT
P
S
P
V
-
K
-
H
-----
P
---
E
--
L
-
T
D
M
V
I
F
R
E
N
S
E
D
I
Y
A
G
I
E
-----------
W
-----------------------
K
-----------------------------
A
-----------------------
D
S
-----
A
D
A
E
---------
K
V
----------------------
I
K
F
L
R
EEMGVKKIRFPEH
C
G
I
G
I
K
P
C
S
E
E
G
T
K
R
L
V
R
A
A
I
E
Y
A
I
A
------------
N
------------
D
R
D
S
V
T
L
V
H
K
G
N
I
M
K
F
T
E
G
A
F
--------------
K
D
-
W
G
---
Y
Q
-
L
A
-
R
----
E
E
FG
G
E
L
I
DGG------
P
--------------------------------
W
--------------------------------
L
K
V
K
N
PNTG
K
E
I
V
I
K
D
V
I
A
------
D
A
F
L
Q
Q
I
L
L
R
P
A
E
Y
D
--
V
I
A
C
M
N
L
N
G
D
Y
I
S
D
A
-
L
A
A
Q
V
-
G
G
I
G
I
A
P
G
A
N
I
G
D
--
E
--
C
A
L
F
E
A
T
H
G
T
A
P
K
Y
A
G
Q
D
K
V
N
P
G
S
-
I
I
L
S
A
E
M
M
L
R
H
-
M
G
W
T
E
A
A
D
L
I
----
V
K
G
M
E
G
A
--
I
--
N
A
KTV
T
Y
D
F
E
R
L
M
D
G
----
A
K
L
L
K
C
S
E
F
G
D
A
I
I
E
N
M
---------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
70.42
31%
-77
- C5 -
4AJA
4
IDH_ECOLI
A:
[34-416]
---------------------------
G
D
G
I
G
V
D
V
-------
T
P
A
M
L
K
V
V
D
--
A
A
V
E
K
A
Y
KG
E
-------
R
K
----------
I
-----
S
W
M
E
I
Y
T
----
G
E
K
S
T
Q
V
Y
G
Q
--
D
V
W
-----
L
P
A
E
T
-
L
D
L
I
R
-
E
Y
R
V
A
I
K
G
P
L
T
------------------
T
P
V
G
--
G
------
G
I
R
S
L
N
V
A
L
R
Q
E
L
D
L
Y
I
C
L
R
P
V
R
Y
Y
-
Q
GT
P
S
P
V
-
K
-
H
-----
P
---
E
--
L
-
T
D
M
V
I
F
R
E
N
S
E
D
I
Y
A
G
I
E
-----------
W
-----------------------
K
-----------------------------
A
-----------------------
D
S
-----
A
D
A
E
---------
K
V
----------------------
I
K
F
L
R
E
EMGVKKIRFPEH
C
G
I
G
I
K
P
C
S
E
E
G
T
K
R
L
V
R
A
A
I
E
Y
A
I
A
------------
N
------------
D
R
D
S
V
T
L
V
H
K
G
N
I
M
K
F
T
E
G
A
F
--------------
K
D
-
W
G
---
Y
Q
-
L
A
-
R
----
E
E
FG
G
E
L
I
DGG------
P
--------------------------------
W
--------------------------------
L
K
V
K
N
PNTG
K
E
I
V
I
K
D
V
I
A
------
D
A
F
L
Q
Q
I
L
L
R
P
A
E
Y
D
--
V
I
A
C
M
N
L
N
G
D
Y
I
S
D
A
-
L
A
A
Q
V
-
G
G
I
G
I
A
P
G
A
N
I
G
D
--
E
--
C
A
L
F
E
A
T
H
G
T
A
P
K
Y
A
G
Q
D
K
V
N
P
G
S
-
I
I
L
S
A
E
M
M
L
R
H
-
M
G
W
T
E
A
A
D
L
I
----
V
K
G
M
E
G
A
--
I
--
N
A
KTV
T
Y
D
F
E
R
L
M
D
G
----
A
K
L
L
K
C
S
E
F
G
D
A
I
I
E
N
M
---------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
70.35
31%
-77
- C5 -
1HQS
5
IDH_BACSU
B:
[27-422]
---------------------------
G
D
G
T
G
P
D
I
WNAASKV
L
E
A
A
V
E
K
A
Y
--
K
G
-------
E
-------
K
K
----------
I
-----
T
W
K
E
V
Y
A
----
G
E
K
---
A
Y
N
K
TG
E
-
W
-----
L
P
A
E
T
-
L
D
V
I
R
-
E
Y
F
I
A
I
K
G
P
L
T
------------------
T
P
V
G
--
G
------
G
I
R
S
L
N
V
A
L
R
Q
E
L
D
L
F
V
C
L
R
P
V
R
Y
F
-
T
GV
P
S
P
V
-
K
-
R
-----
P
---
E
--
D
-
T
D
M
V
I
F
R
E
N
T
E
D
I
Y
A
G
I
E
-----------
Y
AKGSEEVQKLISFLQNELNVNKI
R
F
----
P
-----------------------
E
-----------------------
T
S
-----
G
I
G
I
---------
K
P
----------------------
V
-------------------------
S
E
E
G
T
S
R
L
V
R
A
A
I
D
Y
A
I
E
------------
H
------------
G
R
K
S
V
T
L
V
H
K
G
N
I
M
K
F
T
E
G
A
F
--------------
K
N
W
G
Y
---
E
L
-
A
E
-
K
----
E
Y
---------------
G
--------------------------------
D
KVFTWAQYDRIAEEQGKDAANKAQSEAEAAGK
I
I
I
K
D
-----------
S
I
A
------
D
I
F
L
Q
Q
I
L
T
R
P
N
E
F
D
--
V
V
A
T
M
N
L
N
G
D
Y
I
S
D
A
-
L
A
A
Q
V
-
G
G
I
G
I
A
P
G
A
N
I
N
Y
--
E
TG
H
A
I
F
E
A
T
H
G
T
A
P
K
Y
A
G
L
D
K
V
N
P
S
S
-
V
I
L
S
G
V
L
L
L
E
H
-
L
G
W
N
E
A
A
D
L
V
I
K
S
M
E
K
T
I
A
S
K
--
V
--
V
----
T
Y
D
F
A
R
L
M
D
G
----
A
T
E
V
K
C
S
E
F
G
E
E
L
I
K
N
M
D
--------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
70.10
31%
-77
- C5 -
1BL5
3
IDH_ECOLI
A:
[32-414]
---------------------------
G
D
G
I
G
V
D
V
-------
T
P
A
M
L
K
V
V
D
--
A
A
V
E
K
A
YKG
E
-------
R
K
----------
I
-----
S
W
M
E
I
Y
T
----
G
E
K
S
T
Q
V
Y
G
Q
--
D
V
W
-----
L
P
A
E
T
-
L
D
L
I
R
-
E
Y
R
V
A
I
K
G
P
L
T
------------------
T
P
V
G
--
G
------
G
I
R
S
L
N
V
A
L
R
Q
E
L
D
L
Y
I
C
L
R
P
V
R
Y
Y
-
Q
GT
P
S
P
V
-
K
-
H
-----
P
---
E
--
L
-
T
D
M
V
I
F
R
E
N
S
E
D
I
Y
A
G
I
E
-----------
W
-----------------------
K
-----------------------------
A
-----------------------
D
S
-----
A
D
A
E
---------
K
V
----------------------
I
K
F
L
R
EEMGVKKIRFPEH
C
G
I
G
I
K
P
C
S
E
E
G
T
K
R
L
V
R
A
A
I
E
Y
A
I
A
------------
N
------------
D
R
D
S
V
T
L
V
H
K
G
N
I
M
K
F
T
E
G
A
F
--------------
K
D
-
W
G
---
Y
Q
-
L
A
-
R
----
E
E
FGGELIDGG------
P
--------------------------------
W
--------------------------------
L
K
V
K
N
PNTG
K
E
I
V
I
K
D
V
I
A
------
D
A
F
L
Q
Q
I
L
L
R
P
A
E
Y
D
--
V
I
A
C
M
N
L
N
G
D
Y
I
S
D
A
-
L
A
A
Q
V
-
G
G
I
G
I
A
P
G
A
N
I
G
D
--
E
--
C
A
L
F
E
A
T
H
G
T
A
P
K
Y
A
G
Q
D
K
V
N
P
G
S
-
I
I
L
S
A
E
M
M
L
R
H
-
M
G
W
T
E
A
A
D
L
I
----
V
K
G
M
E
G
A
--
I
--
N
A
KTV
T
Y
D
F
E
R
L
M
D
G
----
A
K
L
L
K
C
S
E
F
G
D
A
I
I
E
N
M
---------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
69.11
34%
-74
- C5 -
3TY3
4
LYS12_SCHPO
A:
[18-364]
---------------------------
A
D
G
I
G
K
E
V
-------
V
P
A
A
R
R
L
M
E
N
L
P
A
-------
K
-------
H
K
----------
L
-----
K
F
D
F
I
D
L
----
D
----------------------
A
G
-
W
G
T
F
E
-
R
T
G
K
A
L
P
E
R
T
V
E
R
L
K
T
ECN
A
A
L
F
G
A
VQSP
T
H
K
V
--
A
------
G
Y
S
S
P
I
V
A
L
R
K
K
M
G
L
Y
A
N
V
R
P
V
K
S
L
-
D
--
G
A
-----
K
-----
G
---
K
--
P
-
V
D
L
V
I
V
R
E
N
T
E
C
L
Y
V
K
-
E
-----------
E
-----------------------
R
M
----
V
-----------------------
Q
-----------------------
N
T
PG
K
R
V
A
E
A
I
---------
R
R
----------------------
I
-------------------------
S
E
E
A
S
T
K
I
G
K
M
A
F
E
I
A
K
S
R
Q
K
I
R
E
S
G
T
Y
S
I
H
------------
K
K
P
L
V
T
I
I
H
K
S
N
V
M
S
V
T
D
G
L
F
--------------
R
E
-
S
C
R
H
A
Q
S
-
L
D
-
P
----
S
Y
---------------
A
--------------------------------
S
--------------------------------
I
N
V
D
E
-----------
Q
I
V
------
D
S
M
V
Y
R
L
F
R
E
P
E
C
F
D
--
V
V
V
A
P
N
L
Y
G
D
I
L
S
D
G
-
A
A
S
L
I
-
G
S
L
G
L
V
P
S
A
N
V
G
D
--
N
--
F
V
M
S
E
P
V
H
G
S
A
P
D
I
A
G
R
G
I
A
N
P
V
A
-
T
F
R
S
V
A
L
M
L
E
F
-
M
G
H
Q
D
A
A
A
D
I
Y
T
A
V
D
K
V
L
T
E
G
K-
V
--
L
----
T
P
D
L
----------
G
G
K
S
G
T
N
E
I
T
D
A
V
L
A
N
I
H
N
-------------------------------------------------------------------------------------------------------------------------------------------------------
102
HHSearch
68.75
30%
-90
- C5 -
2Y3Z
7
LEU3_THET8
A:
[3-351]
-----------------
S
M
K
V
A
V
L
P
--
G
D
G
I
G
P
E
V
-------
T
E
A
A
L
K
V
L
R
--
A
L
D
E
A
E
---
G
-------
L
G
----------
L
-----
A
Y
E
V
F
P
F
----
G
G
A
---
A
I
D
A
----
F
G
--
E
P
F
P
E
P
T
-
R
K
G
V
E
-
E
A
E
A
V
L
L
G
S
V
G
------------------
G
P
K
W
--
D
GLPRKI
R
P
E
T
G
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
-
P
--
G
L
E
R
L
S
-
P
LKEEI
A
---
R
--
G
-
V
D
V
L
I
V
R
E
L
T
G
G
I
Y
F
G
E
P
-----------
R
-----------------------
G
M
----
S
-----------------------
E
-----------------------
A
E
-----
A
W
N
T
---------
E
R
----------------------
Y
-------------------------
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
------------
R
-------------
R
K
H
V
V
S
V
D
K
A
N
V
L
E
V
-
G
E
F
W
--------------
R
K
-
T
V
---
E
E
-
V
G
-
R
----
G
Y
---------------
P
--------------------------------
D
--------------------------------
V
A
L
E
H
-----------
Q
Y
V
------
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
--
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
-
A
S
V
L
P
-
G
S
L
G
L
L
P
S
A
S
L
G
R
--
G
--
T
P
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
-
A
I
L
S
A
A
M
M
L
E
H
A
F
G
L
V
E
L
A
R
K
V
E
D
A
V
A
K
A
L
L
E
---
T
--
P
----
P
P
D
L
G
G
S
----------
A
G
T
E
A
F
T
A
T
V
L
R
H
L
A
A
A
A
L
E
---------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
68.75
31%
-73
- C5 -
4AJ3
3
IDH_ECOLI
A:
[34-416]
---------------------------
G
D
G
I
G
V
D
V
-------
T
P
A
M
L
K
V
V
D
--
A
A
V
E
K
A
Y
K
G
E
-------
R
K
----------
I
-----
S
W
M
E
I
Y
T
----
G
E
K
S
T
Q
V
Y
G
Q
--
D
V
W
-----
L
P
A
E
T
-
L
D
L
I
R
-
E
Y
R
V
A
I
K
G
P
L
T
------------------
T
P
V
G
--
G
------
G
I
R
S
L
N
V
A
L
R
Q
E
L
D
L
Y
I
C
L
R
P
V
R
Y
Y
-
Q
GT
P
S
P
V
-
K
-
H
-----
P
---
E
--
L
-
T
D
M
V
I
F
R
E
N
S
E
D
I
Y
A
G
I
E
-----------
W
-----------------------
K
-----------------------------
A
-----------------------
D
S
-----
A
D
A
E
---------
K
V
----------------------
I
K
F
L
R
EEMGVKKIRFPEH
C
G
I
G
I
K
P
C
S
E
E
G
T
K
R
L
V
R
A
A
I
E
Y
A
I
A
------------
N
------------
D
R
D
S
V
T
L
V
H
K
G
N
I
M
K
F
T
E
G
A
F
--------------
K
D
-
W
G
---
Y
Q
-
L
A
-
R
----
E
E
FG
G
E
L
I
DGG------
P
--------------------------------
W
--------------------------------
L
K
V
K
N
PNTG
K
E
I
V
I
K
D
V
I
A
------
D
A
F
L
Q
Q
I
L
L
R
P
A
E
Y
D
--
V
I
A
C
M
N
L
N
G
D
Y
I
S
D
A
-
L
A
A
Q
V
-
G
G
I
G
I
A
P
G
A
N
I
G
D
--
E
--
C
A
L
F
E
A
T
H
G
T
A
P
K
Y
A
G
Q
D
K
V
N
P
G
S
-
I
I
L
S
A
E
M
M
L
R
H
-
M
G
W
T
E
A
A
D
L
I
----
V
K
G
M
E
G
A
--
I
--
N
A
KTV
T
Y
D
F
E
R
L
M
D
G
----
A
K
L
L
K
C
S
E
F
G
D
A
I
I
E
N
M
---------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
68.72
33%
-85
- C5 -
2E5M
1
?
A:
[32-403]
---------------------------
G
D
G
I
G
P
E
I
-------
T
N
A
A
I
K
V
I
N
--
K
A
-------
V
-------
E
R
A
YGSSREIK
W
L
-----
E
V
Y
A
G
E
K
----
A
E
K
---
L
V
N
D
--
R
-
F
P
--
K
E
T
Q
-----
E
M
L
L
-
K
Y
R
V
V
L
K
G
P
L
E
------------------
T
P
--------------
S
V
N
V
A
I
R
L
M
L
D
L
Y
A
N
I
R
P
V
-
K
Y
-
I
--
E
G
L
E
-
S
-
P
-----
L
KHP
E
--
K
-
V
D
M
I
I
F
R
E
N
T
D
D
L
Y
R
G
I
E
-----------
Y
-----------------------
P
F
----------------------------------------------------
N
S
-----
E
E
A
K
---------
K
I
R
D
F
L
R
K
ELK
V
E
I
E
DD
T
G
I
G
I
K
V
M
-------------------------
S
K
Y
K
T
Q
R
I
T
R
L
A
I
Q
Y
A
I
E
------------
H
------------
K
R
K
K
V
T
I
M
H
K
G
N
V
M
K
Y
T
E
G
A
F
--------------
R
E
W
A
Y
---
E
V
-
A
L
-
K
----
E
Y
---------------
R
--------------------------------
D
FIVT
E
E
E
I
N
Q
GKPDQG
K
---------------
I
I
L
N
D
-----------
R
I
A
------
D
N
M
F
Q
Q
I
I
I
R
P
E
E
Y
D
--
I
I
L
A
P
N
V
N
G
D
Y
I
S
D
A
-
A
G
A
L
I
-
G
N
I
G
M
L
G
G
A
N
I
G
D
--
E
--
G
G
M
F
E
A
I
H
G
T
A
P
K
Y
A
G
K
N
V
A
N
P
T
G
-
I
I
K
A
G
E
L
M
L
R
W
-
M
G
W
N
E
A
A
D
L
I
E
K
A
I
N
M
A
I
R
D
K
--
K
--
V
----
T
Q
D
I
A
R
F
M
G
V
----
K
A
-
L
G
T
K
E
Y
A
D
E
L
I
K
I
M
D
T
I
------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
67.28
31%
-69
- C5 -
1XKD
5
?
B:
[43-421]
---------------------------
G
D
G
V
G
P
E
V
-------
V
E
S
A
L
K
V
V
D
--
A
A
-------
V
-------
K
K
----------
V
GSR--
R
I
V
W
W
E
L
----
L
A
G
---
H
L
A
R
--
E
-
K
C
--
G
E
L
L
P
K
A
T
L
E
G
I
R
-
L
A
R
V
A
L
K
G
P
L
E
------------------
T
P
V
G
--
T
------
G
Y
R
S
L
N
V
A
I
R
Q
A
L
D
L
Y
A
N
I
R
P
V
R
Y
Y
G
Q
--
P
A
P
H
-
K
-
Y
-----
A
---
D
--
R
-
V
D
M
V
I
F
R
E
N
T
E
D
V
Y
A
G
I
E
W
P
HDS
P
E
A
A
R
I
R
-----------------------
R
F
----
L
-----------------------
A
-----------------------
E
E
-----
F
G
I
S
I
R
ED
A
G
I
G
V
K
P
----------------------
I
-------------------------
S
R
F
A
T
R
R
L
M
E
R
A
L
E
W
A
L
R
------------
N
------------
G
N
T
V
V
T
I
M
H
K
G
N
I
M
K
Y
T
E
G
A
F
M
R
W
A
Y
E
V
A
L
E
KFRE
H
V
-
V
T
---
E
Q
E
V
Q
-
E
----
K
Y
---------------
G
--------------------------------
G
--------------------------------
V
R
P
E
G
-----------
K
I
L
V
N
D
R
I
A
D
N
M
L
Q
Q
I
I
T
R
P
W
D
Y
Q
--
V
I
V
A
P
N
L
N
G
D
Y
I
S
D
A
-
A
S
A
L
V
-
G
G
I
G
M
A
A
G
M
N
M
G
D
--
G
--
I
A
V
A
E
P
V
H
G
T
A
P
K
Y
A
G
K
D
L
I
N
P
S
A
E
I
L
S
A
S
L
L
I
G
E
F
-
M
G
W
R
E
V
K
S
I
V
E
Y
A
I
R
K
A
V
Q
S
K
--
K
--
V
----
T
Q
D
L
A
R
H
M
P
G
----
V
Q
P
L
R
T
S
E
Y
T
E
T
L
I
A
Y
I
D
E
A
D
L
----------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
67.28
31%
-72
- C5 -
1ISO
4
IDH_ECOLI
A:
[34-416]
---------------------------
G
D
G
I
G
V
D
V
-------
T
P
A
M
L
K
V
V
D
--
A
A
V
E
K
A
Y
K
G
E
-------
R
K
----------
I
-----
S
W
M
E
I
Y
T
----
G
E
K
S
T
Q
V
Y
G
Q
--
D
V
W
-----
L
P
A
E
T
-
L
D
L
I
R
-
E
Y
R
V
A
I
K
G
P
L
T
------------------
T
P
V
G
--
G
------
G
I
R
S
L
N
V
A
L
R
Q
E
L
D
L
Y
I
C
L
R
P
V
R
Y
Y
-
Q
GT
P
S
P
V
-
K
-
H
-----
P
---
E
--
L
-
T
D
M
V
I
F
R
E
N
S
E
D
I
Y
A
G
I
E
-----------
W
-----------------------
K
-----------------------------
A
-----------------------
D
S
-----
A
D
A
E
---------
K
V
----------------------
I
K
F
L
R
E
EMGVKKIRFPEH
C
G
I
G
I
K
P
M
S
E
E
G
T
K
R
L
V
R
A
A
I
E
Y
A
I
A
------------
N
------------
D
R
D
S
V
T
L
V
H
K
G
N
I
M
K
F
T
E
G
A
F
--------------
K
D
-
W
G
---
Y
Q
-
L
A
-
R
----
E
E
FG
G
E
L
I
DGG------
P
--------------------------------
W
--------------------------------
L
K
V
K
N
PNTG
K
E
I
V
I
K
D
V
I
A
------
D
A
F
L
Q
Q
I
L
L
R
P
A
E
Y
D
--
V
I
A
C
M
N
L
N
G
D
Y
I
S
D
A
-
L
A
A
Q
V
-
G
G
I
G
I
A
P
G
A
N
I
G
D
--
E
--
Y
A
L
F
E
A
T
H
G
T
A
P
D
I
A
G
Q
D
K
A
N
P
G
S
-
I
I
L
S
A
E
M
M
L
R
H
-
M
G
W
T
E
A
A
D
L
I
----
V
K
G
M
E
G
A
--
I
--
N
----
A
K
T
V
T
K
D
F
E
S
L
M
DG
A
K
L
L
K
C
S
E
F
G
D
A
I
I
E
N
M
---------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
67.25
33%
-83
- C5 -
2E5M
1
?
B:
[32-403]
---------------------------
G
D
G
I
G
P
E
I
-------
T
N
A
A
I
K
V
I
N
--
K
A
-------
V
-------
E
R
AYGSSREIKW
L
-----
E
V
Y
A
G
E
K
----
A
E
K
---
L
V
N
D
--
R
-
F
P
--
K
E
T
Q
-----
E
M
L
L
-
K
Y
R
V
V
L
K
G
P
L
E
------------------
T
P
--------------
S
V
N
V
A
I
R
L
M
L
D
L
Y
A
N
I
R
P
V
-
K
Y
-
I
--
E
G
L
E
-
S
-
P
-----
L
KHP
E
--
K
-
V
D
M
I
I
F
R
E
N
T
D
D
L
Y
R
G
I
E
-----------
Y
-----------------------
P
F
----------------------------------------------------
N
S
-----
E
E
A
K
---------
K
I
RDFLRKELKVEIEDDTGIGIKV
M
-------------------------
S
K
Y
K
T
Q
R
I
T
R
L
A
I
Q
Y
A
I
E
------------
H
------------
K
R
K
K
V
T
I
M
H
K
G
N
V
M
K
Y
T
E
G
A
F
--------------
R
E
W
A
Y
---
E
V
-
A
L
-
K
----
E
Y
---------------
R
--------------------------------
D
FIVTEEEINQGKPDQGK---------------
I
I
L
N
D
-----------
R
I
A
------
D
N
M
F
Q
Q
I
I
I
R
P
E
E
Y
D
--
I
I
L
A
P
N
V
N
G
D
Y
I
S
D
A
-
A
G
A
L
I
-
G
N
I
G
M
L
G
G
A
N
I
G
D
--
E
--
G
G
M
F
E
A
I
H
G
T
A
P
K
Y
A
G
K
N
V
A
N
P
T
G
-
I
I
K
A
G
E
L
M
L
R
W
-
M
G
W
N
E
A
A
D
L
I
E
K
A
I
N
M
A
I
R
D
K
--
K
--
V
----
T
Q
D
I
A
R
F
M
G
V
----
K
A
-
L
G
T
K
E
Y
A
D
E
L
I
K
I
M
D
T
I
------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
67.14
34%
-74
- C5 -
3TY4
7
LYS12_SCHPO
B:
[18-364]
---------------------------
A
D
G
I
G
K
E
V
-------
V
P
A
A
R
R
L
M
E
N
L
P
A
-------
K
-------
H
K
----------
L
-----
K
F
D
F
I
D
L
----
D
----------------------
A
G
-
W
G
T
F
E
-
R
T
G
K
A
L
P
E
R
T
V
E
R
L
K
T
ECN
A
A
L
F
G
A
VQSP
T
H
K
V
--
A
------
G
Y
S
S
P
I
V
A
L
R
K
K
M
G
L
Y
A
N
V
R
P
V
K
S
L
-
D
--
G
A
-----
K
-----
G
---
K
--
P
-
V
D
L
V
I
V
R
E
N
T
E
C
L
Y
V
K
-
E
-----------
E
-----------------------
R
M
----
V
-----------------------
Q
-----------------------
N
T
PG
K
R
V
A
E
A
I
---------
R
R
----------------------
I
-------------------------
S
E
E
A
S
T
K
I
G
K
M
A
F
E
I
A
K
S
R
Q
K
I
R
E
S
G
T
Y
S
I
H
------------
K
K
P
L
V
T
I
I
H
K
S
N
V
M
S
V
T
D
G
L
F
--------------
R
E
-
S
C
R
H
A
Q
S
-
L
D
-
P
----
S
Y
---------------
A
--------------------------------
S
--------------------------------
I
N
V
D
E
-----------
Q
I
V
------
D
S
M
V
Y
R
L
F
R
E
P
E
C
F
D
--
V
V
V
A
P
N
L
Y
G
D
I
L
S
D
G
-
A
A
S
L
I
-
G
S
L
G
L
V
P
S
A
N
V
G
D
--
N
--
F
V
M
S
E
P
V
H
G
S
A
P
D
I
A
G
R
G
I
A
N
P
V
A
-
T
F
R
S
V
A
L
M
L
E
F
-
M
G
H
Q
D
A
A
A
D
I
Y
T
A
V
D
K
V
L
T
E
G
K-
V
--
L
----
T
P
D
L
----------
G
G
K
S
G
T
N
E
I
T
D
A
V
L
A
N
I
---------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
66.93
31%
-74
- C5 -
1HQS
7
IDH_BACSU
A:
[27-422]
---------------------------
G
D
G
T
G
P
D
I
W
N
A
A
S
K
V
L
E
A
A
V
E
K
A
Y
--
K
G
-------
E
-------
K
K
----------
I
-----
T
W
K
E
V
Y
A
----
G
E
K
---
A
Y
N
K
TG
E
-
W
-----
L
P
A
E
T
-
L
D
V
I
R
-
E
Y
F
I
A
I
K
G
P
L
T
------------------
T
P
V
G
--
G
------
G
I
R
S
L
N
V
A
L
R
Q
E
L
D
L
F
V
C
L
R
P
V
R
Y
F
-
T
GV
P
S
P
V
-
K
-
R
-----
P
---
E
--
D
-
T
D
M
V
I
F
R
E
N
T
E
D
I
Y
A
G
I
E
-----------
Y
AKG
S
E
E
V
Q
K
L
I
S
F
L
Q
NELNVNKI
R
F
----
P
-----------------------
E
-----------------------
T
S
-----
G
I
G
I
---------
K
P
----------------------
V
-------------------------
S
E
E
G
T
S
R
L
V
R
A
A
I
D
Y
A
I
E
------------
H
------------
G
R
K
S
V
T
L
V
H
K
G
N
I
M
K
F
T
E
G
A
F
--------------
K
N
W
G
Y
---
E
L
-
A
E
-
K
----
E
Y
---------------
G
--------------------------------
D
KVF
T
W
A
Q
Y
D
R
I
A
E
EQ
G
K
D
A
A
N
K
A
Q
S
E
A
E
A
A
G
K
I
I
I
K
D
-----------
S
I
A
------
D
I
F
L
Q
Q
I
L
T
R
P
N
E
F
D
--
V
V
A
T
M
N
L
N
G
D
Y
I
S
D
A
-
L
A
A
Q
V
-
G
G
I
G
I
A
P
G
A
N
I
N
Y
--
E
T
G
H
A
I
F
E
A
T
H
G
T
A
P
K
Y
A
G
L
D
K
V
N
P
S
S
-
V
I
L
S
G
V
L
L
L
E
H
-
L
G
W
N
E
A
A
D
L
V
I
K
S
M
E
K
T
I
A
S
K
--
V
--
V
----
T
Y
D
F
A
R
L
M
D
G
----
A
T
E
V
K
C
S
E
F
G
E
E
L
I
K
N
M
D
--------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
66.19
34%
-72
- C5 -
3TY4
5
LYS12_SCHPO
A:
[18-364]
---------------------------
A
D
G
I
G
K
E
V
-------
V
P
A
A
R
R
L
M
E
N
L
P
A
-------
K
-------
H
K
----------
L
-----
K
F
D
F
I
D
L
----
D
----------------------
A
G
-
W
G
T
F
E
-
R
T
G
K
A
L
P
E
R
T
V
E
R
L
K
T
ECN
A
A
L
F
G
A
VQSP
T
H
K
V
--
A
------
G
Y
S
S
P
I
V
A
L
R
K
K
M
G
L
Y
A
N
V
R
P
V
K
S
L
-
D
--
G
A
-----
K
-----
G
---
K
--
P
-
V
D
L
V
I
V
R
E
N
T
E
C
L
Y
V
K
-
E
-----------
E
-----------------------
R
M
----
V
-----------------------
Q
-----------------------
N
T
PG
K
R
V
A
E
A
I
---------
R
R
----------------------
I
-------------------------
S
E
E
A
S
T
K
I
G
K
M
A
F
E
I
A
K
S
R
Q
K
I
R
E
S
GTYSI
H
------------
K
K
P
L
V
T
I
I
H
K
S
N
V
M
S
V
T
D
G
L
F
--------------
R
E
-
S
C
R
H
A
Q
S
-
L
D
-
P
----
S
Y
---------------
A
--------------------------------
S
--------------------------------
I
N
V
D
E
-----------
Q
I
V
------
D
S
M
V
Y
R
L
F
R
E
P
E
C
F
D
--
V
V
V
A
P
N
L
Y
G
D
I
L
S
D
G
-
A
A
S
L
I
-
G
S
L
G
L
V
P
S
A
N
V
G
D
--
N
--
F
V
M
S
E
P
V
H
G
S
A
P
D
I
A
G
R
G
I
A
N
P
V
A
-
T
F
R
S
V
A
L
M
L
E
F
-
M
G
H
Q
D
A
A
A
D
I
Y
T
A
V
D
K
V
L
T
E
G
K-
V
--
L
----
T
P
D
L
----------
G
G
K
S
G
T
N
E
I
T
D
A
V
L
A
N
I
---------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
65.49
31%
-74
- C5 -
1XKD
6
?
A:
[43-421]
---------------------------
G
D
G
V
G
P
E
V
-------
V
E
S
A
L
K
V
V
D
--
A
A
-------
V
-------
K
K
----------
V
Y
G
GSR
R
I
V
W
W
E
L
----
L
A
G
---
H
L
A
R
--
E
-
K
C
--
G
E
L
L
P
K
A
T
L
E
G
I
R
-
L
A
R
V
A
L
K
G
P
L
E
------------------
T
P
V
------------
R
S
L
N
V
A
I
R
Q
A
L
D
L
Y
A
N
I
R
P
V
R
Y
Y
G
Q
--
P
A
P
H
-
K
-
Y
-----
A
---
D
--
R
-
V
D
M
V
I
F
R
E
N
T
E
D
V
Y
A
G
I
E
W
P
HDS
P
E
A
A
R
I
R
-----------------------
R
F
----
L
-----------------------
A
-----------------------
E
E
-----
F
G
I
S
I
R
ED
A
G
I
G
V
K
P
----------------------
I
-------------------------
S
R
F
A
T
R
R
L
M
E
R
A
L
E
W
A
L
R
------------
N
------------
G
N
T
V
V
T
I
M
H
K
G
N
I
M
K
Y
T
E
G
A
F
M
R
W
A
Y
E
V
A
L
E
KFRE
H
V
-
V
T
---
E
Q
E
V
Q
-
E
----
K
Y
---------------
G
--------------------------------
G
--------------------------------
V
R
P
E
G
-----------
K
I
L
V
N
D
R
I
A
D
N
M
L
Q
Q
I
I
T
R
P
W
D
Y
Q
--
V
I
V
A
P
N
L
N
G
D
Y
I
S
D
A
-
A
S
A
L
V
-
G
G
I
G
M
A
A
G
M
N
M
G
D
--
G
--
I
A
V
A
E
P
V
H
G
T
A
P
K
Y
A
G
K
D
L
I
N
P
S
A
E
I
L
S
A
S
L
L
I
G
E
F
-
M
G
W
R
E
V
K
S
I
V
E
Y
A
I
R
K
A
V
Q
S
K
--
K
--
V
----
T
Q
D
L
A
R
H
M
P
G
----
V
Q
P
L
R
T
S
E
Y
T
E
T
L
I
A
Y
I
D
E
A
D
L
N
E
V
L
A
G
K
R
G
-------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
64.96
34%
-74
- C5 -
3TY3
2
LYS12_SCHPO
B:
[18-363]
---------------------------
A
D
G
I
G
K
E
V
-------
V
P
A
A
R
R
L
M
E
N
L
P
A
-------
K
-------
H
K
----------
L
-----
K
F
D
F
I
D
L
----
D
----------------------
A
G
-
W
G
T
F
E
----
K
A
L
P
E
R
T
V
E
R
L
K
T
ECN
A
A
L
F
G
A
VQSP
T
H
K
V
--
A
------
G
Y
S
S
P
I
V
A
L
R
K
K
M
G
L
Y
A
N
V
R
P
V
K
S
L
-
D
--
G
A
-----
K
-----
G
---
K
--
P
-
V
D
L
V
I
V
R
E
N
T
E
C
L
Y
V
K
-
E
-----------
E
-----------------------
R
M
----
V
-----------------------
Q
-----------------------
N
T
PG
K
R
V
A
E
A
I
---------
R
R
----------------------
I
-------------------------
S
E
E
A
S
T
K
I
G
K
M
A
F
E
I
A
K
S
R
Q
K
I
R
E
S
G
T
Y
S
I
H
------------
K
K
P
L
V
T
I
I
H
K
S
N
V
M
S
V
T
D
G
L
F
--------------
R
E
-
S
C
R
H
A
Q
S
-
L
D
-
P
----
S
Y
---------------
A
--------------------------------
S
--------------------------------
I
N
V
D
E
-----------
Q
I
V
------
D
S
M
V
Y
R
L
F
R
E
P
E
C
F
D
--
V
V
V
A
P
N
L
Y
G
D
I
L
S
D
G
-
A
A
S
L
I
-
G
S
L
G
L
V
P
S
A
N
V
G
D
--
N
--
F
V
M
S
E
P
V
H
G
S
A
P
D
I
A
G
R
G
I
A
N
P
V
A
-
T
F
R
S
V
A
L
M
L
E
F
-
M
G
H
Q
D
A
A
A
D
I
Y
T
A
V
D
K
V
L
T
E
G
K-
V
--
L
----
T
P
D
L
----------
G
G
K
S
G
T
N
E
I
T
D
A
V
L
A
N
----------------------------------------------------------------------------------------------------------------------------------------------------------