@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0384: (2015-12-01 )
MSNYIQNSGTRVIRDELQATGKVRENEDQPVENIKITNDHAFYKLICEKLVQGDFSVEQFNLLHYDISEKMIEKPFTIKEINDFCEKNDIPLFTVNELLTLVPKDDIKCYVDYETDSVRNHDHGYIADQINIKASYIKADLVNHQSYQDYITDSDTYYGFIYKKLIVSDALEKLERGETEAQIRESLGNINRKEIKELLEKVPQGSLKEWLSDPANKGYTDVEYHVLYEKISEELVHTSMSINRIKEIYDKYGIVPPTESEFESLKKVQGEKRSIEYHEQKTGLTFQGRINLNVTDNNADNEFSLNIDLFQNKNFEDLTDQNGDGVINNEGLLKSLEDTVKTFNEVFGIKKDNNPLLVYGNIANFRLFLFESKESYQKYLSGDHDAHIPGGGVAQFSDNNYISNMYSHAENARSDFNGDKEGNCKDYNYVIKHELVHALTFYLTSKLDLGKVLMEGLAEYVTHLTEGEKPADFAKLVGEEYKEHTLEEIIKGAVDPYQTGAAIIAYIEETYPNFIDNLLYAATEDRKTLNGRFYFKEMMQKIYQSEEDKIQKGEGFSNWVKTYSSAENITIEPGHAQHEQQAVGNEKDEAQSYSSKGQVSEDRTEVHPTGSFRGLEVPKKPVIHEQNKGQENIVLKDTILKIEKSYERDSEGKHKANVIIDYYDMKALYDRVAGAKKQSVLKFWNKLAESEYKVGALSEDKYYFKDGKFVIHDSNEKKLVVLPEDKVSIKIMKDGNHYDLAISNKEGKVISSITKIDNLNYELLLDISDFSLEAQDSTTFSDQHNEYDLYLENGLVKMFDCASDHIYHDHSLI
Atome Classification :
(20 SA)
-----------------------------------.........10........20........30....-------------....40........50..--......60..-----------------------......70........80.-....-...90........100.......110......--...120.......130....-----------------...140......-------.150......--.160.........170.......--180........190.......200-----........210........220.......230--.......-------------240......-.250.......260.....--..270.......280.......290.......300......-.310...----------.-...320.......330.-.-.....340.......350.......---360.......370-.....--..380..-----.....390.......-400.......410.---......420........430.---------......440------.-...-----.-----.-..450....-----...460-----.........----470.---...----.-----.------.----------.----480-..-.---...-----..490--.--------.--------.......500...-------....510--.--....---..----520....-....530.......540.......550-.......560.......570.......580...---------....590.......600.......610.......620.-------......630.......640.......650...-------------....660.....-..670.......680---.......690.......700-------.........710....-----...720.......730.......740..-..----------....750.......760.......770.......780-----------------.........---------790.-------......800.......810.------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------MS
N
Y
I
QNSG
T
R
V
I
R
D
E
L
Q
ATGKVRENEDQPV
E
N
I
K
-------------ITN
D
H
A
F
Y
K
L
I
C
E
K
L
V
QG--DF
S
V
E
Q
F
N
L
L
-----------------------
H
YD
I
S
E
K
M
I
EKPF
T
I
K
E
I
N
-
D
F
C
E-KNDI
P
L
F
T
V
N
E
L
L
T
LVPKD
D
I
K
C
Y
--
V
D
YETD--SVRNHDH
G
Y
I
A
D
Q
I
N
I
K
A
S
Y
-----------------
I
K
A
D
LVN
H
Q
S
Y
Q
-------
D
YITDSD
T
Y
Y
--
G
F
--
I
Y
K
K
L
I
V
S
D
A
L
E
K
L
ERG
E
T
--
E
A
-
Q
I
R
E
S
LGNI
N
R
K
E
I
K
E
L
L
E
K------VP
Q
G
S
L
K
E
W
-
L
SDPANKGYTD
V
E
Y
H
V
L
Y
E
K
I
S
--
E
E
L
V
H
T
S-------------M
S
I
N
R
I
K
E
I
-
Y
D
KYGIVPP
T
E
S
E
F
E
S
L
K
K
--VQGEKRS
I
E
Y
HEQKT
G
L
T
F
Q
G
R
I
N
L
N
V
TDNNAD
N
E
F
S
L
N
I
D
-
L
FQNKNF----------E-DLTDQNGDGVIN
N
E
G
L
L
-
K
-
S
L
E
D
T
V
K
T
F
N
E
V
FGIKKDNN
P
L
L
V
Y
---GNIA
N
F
R
L
F
L
F
ES-
K
E
S
Y
Q
--
K
Y
LSGDH-----DAHIPGGGVAQFSDN-
N
Y
I
S
N
M
Y
S
H
A
E
NAR---SDFNGDKE-GNCKD
Y
N
Y
V
I
K
H
---------
E
L
V
H
A
L
T
F
-------
Y
-
L
TS-----K-----L-
D
L
G
K
V
L
M
E
G
-----
L
A
E
Y
-------
V
T
H
L
TEGEK----
P
A
-
D
---
F
A
K
----
L
-----
V
------
G
----------
E
----
E
Y
--
K
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-
H
---
T
L
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-----
E
I
I
----
K
--------G--------AVD
P
Y
QT
G
A
A
I
I
A
-------
Y
I
E
E
T
Y
P
--
N
--
F
I
D
N
---
L
L
----
Y
A
-ATED-RKTLN
G
R
F
Y
F
K
E
M
M
Q
K
I
Y
QS
E
E
DKIQK-GE
G
F
S
N
W
V
K
T
YSSAE
N
I
T
IEPGH
A
Q
H
E
Q
Q
AVGN---------
E
K
D
E
A
Q
SYSSKGQVSEDRTEVHPTGSFRGLEVPKKPVI-------HEQNKGQE
N
I
V
L
K
D
T
I
L
K
I
E
K
S
YERDSEGK
H
K
-------------
A
N
V
I
I
D
Y
Y
D
M
K
A
-
L
Y
D
R
VAGA
K
K
Q
S
V
L
K
---
F
W
N
K
L
A
ESEYKVGALSED---------
K
Y
Y
FKDG
K
F
V
I
HDSNE-----
K
K
L
V
V
LPED
K
V
S
I
K
I
M
KDGN
H
Y
D
L
A
-IS-NK----------EG
K
V
I
S
S
I
T
KIDNL
N
Y
E
L
L
L
D
ISD
F
S
L
EAQDSTTF-------------------SDQHN
E
Y
D
L
---------
Y
LEN-------G
L
V
K
M
F
DCASDHIYHDHSLI------------------
32
Fugue
84.72
15%
-13
- C2 -
5CZZ
7
?
A:
[6-1055]
R
N
Y
I
L
G
L
DIGIT
S
V
G
Y
G
I
I
D
YETRDVI
D
A
G
V
R
L
F
K
E
A
N
V
E
N
N
E
G
R
R
S
K
R
G
A
R
R
L
K
R
R
R
R
H
R
I
Q
R
V
K
K
L
L
F
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Y
NLLTDHSELSG
I
N
P
Y
E
A
R
V
K
G
L
S
Q
K
L
S
E
E
--
E
F
S
A
A
L
L
H
L
A
K
R
R
G
V
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NVNE
V
E
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D
TGNELS
T
K
E
Q
I
S
R
N
S
K
A
L
E
E
K
Y
V
A
E
L
Q
L
-
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R
L
K
-
K
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R
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N
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F
K
T
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Y
V
K
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A
K
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--
L
K
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A
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Q
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I
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T
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R
R
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Y
YEGPGEGSPFGWKD
I
K
E
W
Y
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M
L
M
G
H
C
T
Y
F
PEELRSV
K
Y
A
Y
N
A
D
L
Y
N
--
A
L
N
D
L
N
N
L
V
I
T
R
D
E
N
E
K
L
E
Y
Y
E
K
--
F
Q
-
I
I
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N
V
F
K
Q
K
K
K
P
T
L
K
Q
I
A
K
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I
L----
V
N
E
E
D
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K
G
Y
R
V
T
S
T
G
K
P
E
F
T
N
L
K
V
Y
H
D
I
K
D
I
T
AR
K
E
I
I
E
N
A
-------------
E
L
L
D
Q
I
A
K
I
-
L
T
I
Y
Q
S
S
E
D
I
Q
E
E
L
T
N
L
N
S
EL
T
Q
E
E
I
E
Q
I
S
N
L
K
G
Y
T
G
T
H
N
L
S
L
K
A
I
N
L
I
L
D
E
L
W
H
T
N
D
N
Q
I
A
-
I
F
N
R
L
K
L
V
P
K
K
V
D
LSQQ
K
-
E
I
P
T
T
L
V
D
D
F
I
L
S
P
V
V
K
-
R
-
S
F
I
Q
S
I
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V
I
N
A
I
I
K
K
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I
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L
A
R
E
K
N
S
K
D
A
Q
K
M
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N
E
-
M
Q
K
R
N
--
R
Q
T
N
E
R
I
-----
E
E
I
I
R
T
T
G
K
E
N
A
K
Y
L
-
I
E
K
I
K
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Q
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K
C
LYS
L
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A
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P
L
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D
-
L
L
N
N
P
F
N
Y
E
V
D
H
---------
I
I
P
R
S
V
S
F
DNSFNN
K
V
-
L
V
K
-----
Q
-----
E
-
E
A
S
K
K
G
N
R
T
-----
P
F
Q
Y
L
S
SSDSK
I
S
Y
E
T
F
K
K
H
----
I
L
-
N
---
L
A
K
GKG-
R
-----
I
------
S
----------
K
----
T
K
--
K
E
-
Y
---
L
L
E
-----
E
---------------
R
--------
D
I
N
R
F
S
V
Q
K
D
F
I
N
R
NLVDTR
Y
A
T
R
G
L
M
--
N
--
L
L
R
S
---
Y
F
----
R
V
-
N
N
L
D
-
V
K
V
K
S
I
N
G
G
F
T
S
F
L
R
R
K
W
K
F
K
K
E
R
N
K
G
-
Y
K
H
H
A
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D
A
L
I
I
A
N
A
D
F
I
F
K
E
W
K
K
L
D
K
A
K
K
V
M
E
N
QMFMPEIET
E
Q
E
Y
K
E
I
F
I
T
P
H
Q
I
K
H
I
K
D
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K
D
Y
K
Y
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R
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K
P
N
R
E
L
I
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T
L
Y
S
T
R
K
D
D
K
G
N
T
L
I
V
N
N
L
N
G
L
Y
D
K
D
N
D
K
L
K
K
L
I
N
K
S
-------------
P
E
K
L
L
M
Y
H
H
D
P
Q
-
T
Y
Q
K
L
K
L
I
M
E
Q
Y
G
D
E
KN
P
L
Y
K
Y
Y
E
E
T
G
N
Y
L
T
K
Y
S
K
K
DN
G
P
V
I
K
K
I
K
Y
Y
G
N
K
L
N
A
H
L
D
I
T
D
D
YPNSR
N
K
V
V
K
L
S
L
K
P
Y
R
F
D
V
Y
L
D
N
G
V
Y
K
F
V
T
V
K
-
N
L
----------
D
V
I
K
K
E
N
Y
Y
E
V
N
S
K
A
Y
E
E
A
K
K
L
K
K
I
S
N
Q
A
E
F
I
A
S
F
YNND
L
I
K
I
NG
E
L
Y
R
V
IGVN
N
D
L
L
N
R
I
E
V
N
M
I
DIT
Y
R
E
Y
L
E
N
M
NDKRPP
R
I
I
K
T
I
A
S
K
T
Q
S
I
K
K
Y
S
T
D
I
LG
N
L
Y
E
V
K
S
K
K
HPQIIKK
33
Fugue
76.29
12%
2
- C2 -
3MMP
1
RDRP_BPQBE
F:
[7-573]
-------------------------------------------------
S
R
N
S
L
S
A
Q
L
R
R
A
A
N
T
R
I
E
-----------------------------------------------------------------------------
V
E
G
N
L
A
L
S
I
A
N
-
D
L
L
L
-
A
Y
G
Q
S
P
F
N
S
---------------------
E
A
--
E
C
I
S
F
S
P
R
F
D
G
T
P
D
D
F
R
I
N
Y
-----------------
L
K
A
E
I
M
S
K
Y
D
---------------------
D
F
--
S
L
G
I
D
T
E
A
V
A
W
E
K
F
L
A
A
E
A
--
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C
A
L
T
N
A
R
L
Y
R
P
F
N
F
S
L
G
E
S
C
I
H
------
M
A
R
R
K
I
A
K
L
-
I
G
D
V
P
S
--
V
E
G
M
L
R
H
C
R
F
S
G
-
G
--
A
T
T
T
N
N
R
-------------
S
Y
G
H
P
S
F
K
F
-
A
L
P
Q
A
C
T
P
R
A
L
K
Y
V
L
A
L
R
A
----------
S
T
H
F
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I
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N
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A
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P
G
W
N
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F
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----------
Q
-
L
G
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G
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R
L
R
C
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G
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----
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L
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N
L
A
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---
L
S
A
A
S
D
S
I
----
S
-
L
A
L
C
E
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L
L
L
P
---------------------------
P
G
W
F
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L
M
D
L
R
---
S
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K
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R
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P
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-
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S
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V
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Y
E
K
I
-----------------
S
S
M
-------
G
-
N
G
Y
-----
T
-----
F
-
E
L
E
S
L
I
F
A
S
-----
L
A
R
S
-------
V
C
E
I
L
D
L
D
--------------------------------------------------------------------------
S
--------
S
--------
E
V
T
V
Y
G
D
D
I
I
L
P
S
-------
C
A
V
P
A
L
R
--
E
--
V
F
K
Y
---
V
G
----
F
T
-
T
N
T
K
-
K
T
F
S
E
G
P
--
F
R
E
S
C
G
K
H
Y
Y
S
G
V
D
------------
V
T
P
F
Y
I
R
H
R
I
V
--------
S
P
A
D
L
I
L
---------
V
L
N
N
L
Y
R
W
A
T
I
D
G
V
W
D
------------------------------------------
P
R
A
H
S
V
Y
L
K
Y
R
K
L
L
P
K
Q
L
Q
-------------
R
N
T
I
P
D
G
Y
G
D
G
A
-
L
V
G
S
V
L
I
N
P
F
A
K
N
R
--------------------------------------------
G
W
I
-----
R
Y
V
P
V
I
T
D
H
T
R
D
R
E
R
A
E
L
G
S
Y
L
Y
D
L
-
F
S
-
R
C
----------
L
S
C
-------------------
D
S
A
D
L
F
A
I
D
Q
L
I
C
-------------------
R
S
N
P
T
K
I
S
R
---------
S
T
G
K
-------
F
D
I
Q
Y
I
A
C
S
S
R
V
L
A
------------------------
36
Fugue
75.21
15%
2
- C2 -
2J04
-
TFC8_YEAST
A:
[2-588]
----------------------------------------------
K
L
L
K
D
L
L
V
D
R
K
E
F
E
D
---
W
K
N
N
L
T
-------------
W
A
R
D
G
T
L
Y
L
T
T
F
P
D
I
S
I
G
--
Q
P
K
Y
A
K
-----------------------------
D
I
N
C
N
-
S
K
N
L
F
H
V
K
E
F
P
L
E
F
E
N
-
K
L
D
F
E
L
A
Q
Q
N
G
L
L
N
S
Q
P
V
C
Y
P
R
V
C
--
K
P
------
S
P
I
D
D
W
M
A
V
L
S
N
N
G
N
------------------------
V
S
V
F
K
D
N
K
M
L
-------
T
N
L
D
S
K
G
N
L
S
--
S
R
--
T
Y
H
C
F
E
W
N
P
I
E
S
S
I
V
V
G
N
E
--
D
G
-
E
L
Q
F
F
S
I
R
K
N
S
E
N
T
P
E
F
Y
F
E
------
S
S
I
R
------
L
S
D
A
G
S
K
D
W
------
V
T
H
I
V
W
Y
--
E
D
V
L
V
A
A
-------------
L
S
N
N
S
V
F
S
M
-
T
V
S
A
S
S
H
Q
P
V
S
R
M
I
Q
N
--
A
--
S
R
R
K
I
T
D
L
K
I
V
D
Y
K
V
V
L
T
C
P
G
Y
V
H
K
I
D
L
K
N
Y
--
S
I
S
S
L
K
T
G
-
S
L
E
N
F
H
I
----------
I
-
P
L
N
H
E
K
E
S
T
I
L
----
L
M
-
S
-
N
K
T
S
Y
K
V
L
L
E
D
E
L
H
V
T
A
D
N
I
I
---------
A
P
Y
L
E
K
K
F
K
K
W
-
S
T
I
W
N
--
E
F
N
N
Y
E
T
-----
T
L
V
I
H
G
--
I
S
L
S
P
D
G
-
Y
S
I
A
I
V
Y
D
M
E
R
------------------
V
A
F
K
Y
K
I
A
S
---------
E
Q
S
F
N
I
M
F
-------
A
P
L
Y
H
-----
T
-----
W
-
T
I
S
E
R
-
A
V
G
-----
L
A
W
Y
-------
Q
T
Y
Q
I
Y
N
Q
S
----
L
P
-
K
---
L
P
E
----
N
-----
F
------
S
----------
M
----
N
K
--
K
---------------
L
L
----
N
--------
G
--------
N
Y
P
I
S
L
D
F
Q
S
Y
L
N
-------
A
L
M
K
S
--------------------------------------
E
E
M
R
I
I
M
F
L
N
M
T
I
D
K
P
S
-
I
L
S
F
L
E
A
L
Y
E
Y
A
I
N
K
K
S
E
L
T
------------
N
---------
S
F
D
L
A
C
V
L
S
I
A
A
I
L
K
R
E
A
P
I
Y
N
G
T
L
L
M
K
N
S
F
L
E
E
T
F
N
L
-------
E
S
F
T
A
D
P
E
T
V
T
---------------
S
T
T
N
N
---------------------------------------------
T
W
K
R
C
G
--------------------------------------------
V
T
L
L
P
-------------------------------------
I
L
T
T
H
V
K
I
C
P
V
S
K
Q
R
V
I
D
I
K
R
-------------------------------
D
D
L
N
D
Y
G
----------
W
F
T
R
-------
G
L
L
E
R
F
N
E
I
S
V
Y
C
G
T
T
L
E
V
M
------------------
15
HHSearch
58.87
15%
-62
- C4 -
2Y3U
1
?
A:
[340-571]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
R
L
Y
-
W
-
A
S
R
E
V
K
S
Q
F
H
R
V
V
G
N
D
--
K
A
L
E
V
G
----
N
A
D
D
V
L
T
M
K
I
F
N
S
-
P
E
E
Y
K
---
F
N
T
N
I
N
-----
G
V
S
T
D
N
G
G
-
L
Y
I
E
P
R
G
T
F
Y
T
Y
E
R
T
P
Q
Q
------------
S
I
-
F
S
---
L
E
E
L
F
R
H
---------
E
Y
T
H
Y
L
Q
A
-------
R
-
Y
L
V
DGLWG
Q
GPFYE
K
-
N
R
L
T
W
F
D
E
G
-----
T
A
E
F
-------
F
A
G
S
T
R
T
S
G
----
V
L
-
P
R
K
L
I
L
G
----
Y
-----
L
------
A
KD--------
K
----
V
D
--
H
R
-
Y
---
S
L
K
-----
K
T
L
----
N
--------
S
DDS-----
D
W
M
F
Y
N
Y
G
F
A
V
A
H
-------
Y
L
Y
E
K
D
M
--
P
--
T
F
I
K
---
M
N
----
K
A
-
I
L
N
T
-
D
V
-
K
S
----
Y
D
E
I
I
K
K
L
-
S
D
--
D
A
-
N
K
-
N
T
E
Y
Q
N
H
I
Q
E
L
V
D
K
Y
Q
G
A
G
I
P
L
V
S
D
D
Y
L
K
D
H
G
Y
---------
K
K
A
S
E
V
Y
S
E
I
S
K
A
A
S
L
T
N
T
S
V
T
A
E
K
S
Q
Y
F
N
T
F
T
L
R
G
T
Y
-------
T
G
E
T
S
K
G
E
F
K
D
W
D
E
M
S
K
K
L
D
G
T
L
E
S
L
A
K
N
S
W
S
-------------
G
Y
K
T
L
T
A
Y
F
T
N
Y
-
R
V
T
S
D
N
K
V
Q
Y
D
V
V
F
H
---
G
V
L
T
D
N
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
52.37
22%
42
- C4 -
3ZPJ
-
?
A:
[142-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
I
I
G
A
E
T
S
Y
T
H
K
V
D
G
I
L
R
I
G
D
L
L
E
K
A
G
D
T
LP
S
N
E
A
M
D
F
Y
K
M
A
F
D
I
F
D
K
L
H
V
N
Q
R
A
A
I
V
E
---
K
K
I
E
L
A
K
T
V
Y
D
V
G
----------------------------------------
L
P
Q
I
R
A
A
L
--
L
K
G
K
N
H
Y
A
L
A
-
I
I
-
K
K
K
YSG
V
M
R
L
I
G
E
L
E
V
A
L
W
M
K
R
V
N
N
M
E
Y
---
L
D
V
V
D
K
A
F
E
C
C
E
S
P
R
F
-------------------
T
D
V
N
V
Q
H
I
A
---------
R
L
L
T
-------
E
L
G
N
L
R
R
A
L
K
F
A
K
E
I
Q
N
I
H
K
------------------
17
HHSearch
51.89
19%
-11
- C4 -
2XQ0
3
LKHA4_YEAST
A:
[295-460]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
D
V
I
A
H
---------
E
L
A
H
S
W
S
G
-------
N
-
L
V
T
-----
N
C----
S
-
W
N
H
F
W
L
N
E
G
-----
W
T
V
Y
-------
L
E
R
R
I
I
G
A
I
HG
E
P
T
R
-
H
---
F
S
A
----
L
I
G
---
W
S
D
L
Q
N
S
I
----------
D
----
S
M
K-
D
P
-
E
RFS
T
L
V
-----
Q
N
L
----
N
--------
D
NTDPDDAF
S
T
V
P
Y
E
K
G
F
N
L
L
F
-------
H
L
E
T
I
L
G
--
G
KA
E
F
D
P
---
F
I
----
R
H
-
Y
F
K
K
F
A
K
K
S
L
D
T
F
Q
F
L
D
T
L
Y
E
F
Y
P
E
K
K
E
--
I
L
D
S
V
D
W
E
T
W
L
Y
K
P
G
M
P
P
R
P
H
F
I
T
A
L
A
D
N
V
Y
Q
L
A
D
K
---------
W
V
E
M
A
Q
H
L
K
T
T
E
D
F
R
S
E
F
N
A
I
D
I
K
D
F
N
S
N
Q
L
V
L
F
L
E
T
L
-------
T
Q
N
G
H
S
N
K
K
P
K
D
F
D
W
A
K
F
P
V
A
S
R
A
L
L
D
I
Y
Q
D
N
-------------
I
V
K
S
Q
N
A
E
V
V
F
K
-
M
F
K
F
Q
I
F
A
K
L
Q
E
E
Y
K
---
H
L
A
D
W
L
G
T
V
G
R
M
K
F
V
R
P
G
---------
Y
R
L
L
N
S
V
D
R
R
L
A
L
A
T
F
-----
D
K
F
K
D
T
Y
H
P
I
C
K
A
L
V
K
Q
D
L
K
L
---------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
49.51
24%
29
- C4 -
4GF1
1
CRAX_BACCE
A:
[249-437]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
L
T
I
S
E
K
D
I
I
T
G
Y
--
T
G
S
K
Y
D
--
P
I
N
E
Y
L
R
K
Y
D
G
----
I
G
G
D
L
-----------------
D
K
K
S
K
K
A
L
E
K
I
E
-------
N
Q
I
K
N
L
D
A
A
L
Q
K
S
K
--
I
T
E
N
L
I
V
Y
R
R
V
S
E
L
Q
F
G
K
K
YE
D
Y
-
N
L
R
Q
N
-
G
I
I
N
E
E
K
V
M
E
L
E
S
N
FKG
Q
T
F
I
Q
H
N
Y
M
S
T
S
-
L
V
Q
D
P
H
Q
S
Y
S
N
D
R
Y
P
I
L
L
E
I
T
I
--
P
E
G
V
H
G
A
Y
IADMSEYPGQY
E
M
L
I
N
R
G
Y
T
F
K
Y
D
K
F
S
I
V
K
P
T
R
E
E
D
K
G
K
E
Y
--
L
K
V
N
L
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
49.08
19%
-4
- C4 -
3CIA
1
?
A:
[294-456]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
N
L
I
A
H
---------
E
L
A
H
S
W
S
G
-------
N
-
L
V
T
-----
N
-----
E
S
W
R
D
L
W
L
N
E
G
-----
F
T
S
Y
-------
V
E
N
R
I
M
E
A
V
FG
T
D
R
A
-
V
---
M
E
Q
----
A
-----
L
------
G
A
Q
D
L
N
A
E
I
L
E
L
----
D
A
--
S
D
-
T
---
Q
L
Y
-----
I
D
L
----
K
GRDPDDA-
F
--------
S
G
V
P
Y
V
K
G
Q
L
F
L
M
-------
Y
L
E
E
K
F
G
--
R
E
-
R
F
D
A
---
F
V
L
E
Y
F
D
S
-
H
A
F
Q
-
S
L
---
G
T
D
N
F
V
K
Y
L
K
A
N
L
T
D
K
Y
P
N
I
V
S
-
D
N
E
I
N
E
W
I
F
K
A
G
L
P
S
Y
A
P
Q
P
T
S
N
A
F
K
V
I
D
K
Q
I
N
---------
Q
L
V
T
D
E
L
T
L
E
Q
L
P
T
A
Q
W
T
L
H
E
W
L
H
F
I
N
N
L
P
V
D
L
D
H
Q
M
V
-------
N
L
D
K
A
F
D
L
T
N
S
S
N
A
E
I
A
H
A
W
Y
L
L
S
V
R
A
D
Y
K
E
V
-------------
Y
P
A
M
A
K
Y
L
K
S
I
G
-
R
R
K
L
I
V
P
L
Y
K
E
L
A
K
N
---
A
E
S
K
A
W
A
V
E
V
Y
K
Q
A
R
P
G
Y
---------
H
G
L
A
Q
G
T
V
D
G
V
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
48.19
19%
-14
- C4 -
3U9W
4
LKHA4_HUMAN
A:
[288-451]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
V
I
A
H
---------
E
I
S
H
S
W
T
G
-------
N
-
L
V
T
-----
N
-----
K
T
W
D
H
F
W
L
N
E
G
-----
H
T
V
Y
-------
L
E
R
H
I
C
G
R
L
FG
E
K
F
R
-
H
---
F
N
A
L
G
--
G
-----
W
------
G
E
L
Q
N
S
V
----
K
----
T
F
G-
E
T
-
H
---
P
F
T
-----
K
L
V
----
V
DLTDIDPD
V
AY------
S
S
V
P
Y
E
K
G
F
A
L
L
F
-------
Y
L
E
Q
L
L
G
G
P
E
--
I
F
L
G
---
F
L
K
A
Y
V
E
K
-
F
S
Y
K
-
S
I
---
T
T
D
D
W
K
D
F
L
Y
S
Y
F
K
D
K
V
D
V
--
L
N
Q
V
D
W
N
A
W
L
Y
S
P
G
L
P
P
I
K
P
N
Y
D
M
T
L
T
N
A
C
I
A
L
S
Q
---------
R
W
I
T
A
K
E
D
D
L
N
S
F
N
A
T
D
L
K
D
L
S
S
H
Q
L
N
E
F
L
A
Q
T
L
Q
R
A
P
-------
L
P
L
G
H
I
K
R
M
Q
E
V
Y
N
F
N
A
I
N
N
S
E
I
R
F
R
W
L
R
L
C
I
-------------
Q
S
K
W
E
D
A
I
P
L
A
L
-
K
M
A
T
E
Q
G
R
M
K
F
T
R
P
L
---
F
K
D
L
A
A
F
D
K
S
H
D
Q
A
V
R
T
Y
---------
Q
E
H
K
A
S
M
H
P
V
T
A
M
L
V
G
-----
K
D
L
K
V
D
------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Fugue
46.28
20%
34
- C3 -
4FPR
-
?
A:
[1-130]
---------------------------------------------
A
Y
V
C
R
E
A
S
I
S
G
E
I
R
Y
P
Q
G
T
C
------------------
P
T
K
T
E
A
L
N
D
--
C
N
K
V
T
K
G
L
I
D
F
S
Q
S
H
Q
R
A
W
-----------------------
G
I
D
M
T
A
K
V
Q
C
A
P
C
K
T
T
D
P
W
-
D
V
V
L
C
T
C
K
I
T
A
H
R
Y
R
E
F
V
P
K
I
P
Y
S
S
F
S
S
A
PG
V
I
F
R
Q
E
--
T
G
L
D
H
D
P
E
W
---
V
V
N
M
K
A
R
T
-----------------
R
G
C
D
H
H
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
46.06
16%
-9
- C4 -
3B34
7
AMPN_ECOLI
A:
[312-465]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
R
V
I
G
H
---------
E
Y
F
H
N
W
T
G
-------
N
-
R
V
T
C----
R
-----
D
-
W
F
Q
L
S
L
K
E
G
-----
L
T
V
F
-------
R
D
Q
E
F
S
S
D
L
GS
R
-
A
V
N
R
---
I
N
N
V
R
--
T
M
R
G
L
Q
F
------
A
----------
E
----
D
A
SP
M
A
-
H
---
P
I
R
-----
P
D
M
VIEM
N
NF------
Y
--------
T
L
T
V
Y
E
K
G
A
E
V
I
R
-------
M
I
H
T
L
L
G
--
E
E
-
N
F
Q
K
---
G
M
----
Q
L
Y
F
E
R
H
-
D
G
S
A
A
T
C
D
D
F
V
Q
A
M
E
D
A
S
N
V
-----
D
L
-
S
H
-
F
R
R
W
Y
S
Q
S
G
T
P
I
V
T
V
K
D
D
Y
N
P
E
T
E
Q
Y
T
L
T
I
---------
S
Q
R
T
P
A
T
P
D
Q
A
E
K
Q
P
L
H
I
P
F
A
I
E
L
Y
D
N
E
G
K
V
I
P
L
Q
K
G
G
-------
H
P
V
N
S
V
L
N
V
T
Q
A
E
Q
T
F
V
F
D
N
V
Y
F
Q
P
V
P
A
L
L
C
E
-------------
F
S
A
P
V
K
L
E
Y
K
W
S
-
D
Q
Q
L
T
F
L
M
R
H
A
R
N
D
F
---
S
R
W
D
A
A
Q
S
L
L
A
T
Y
I
K
L
N
V
---------
A
R
H
Q
Q
G
Q
P
L
S
L
P
V
H
V
A
-----
D
A
F
R
A
V
L
L
D
E
K
I
D
P
A
L
A
A
E
I
L
T
L
P
S
-
V
N
-
E
M
----------
A
E
L
F
D
I
I
D
P
I
A
I
A
E
V
R
E
A
L
T
R
T
L
A
T
E
L
A
D
E
L
L
A
I
Y
-------------------
N
A
N
Y
Q
S
E
Y
R
---------
V
E
H
E
-------
D
I
A
K
R
T
L
R
N
A
C
L
R
F
L
A
F
G
E
T
------------------
35
Fugue
41.76
15%
-10
- C2 -
4KSJ
3
OTUL_HUMAN
A:
[2-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
L
S
V
A
P
E
M
D
I
----------------
M
D
Y
C
K
K
E
W
R
G
N
-
T
Q
K
A
T
C
M
K
M
G
Y
E
E
V
S
Q
K
F
T
S
I
R
R
V
R
G
D
N
Y
-----------
C
A
L
R
A
T
L
F
Q
A
M
S
Q
A
V
G
LP
P
W
L
Q
D
P
E
L
M
L
L
P
E
K
L
I
S
K
Y
N
W
I
K
Q
W
K
L
-
D
L
V
D
K
I
K
E
S
L
T
L
L
R
---
K
K
W
A
G
L
A
E
M
R
T
A
E
A
R
Q
I
A
C
D
E
L
F
TNE
A
E
E
Y
S
L
Y
E
A
V
K
F
-------
L
M
L
N
R
-----
A
-----
I
-
E
L
Y
N
D
K
E
K
G
KEVP
F
F
S
V
L
-------
L
F
A
R
D
T
S
N
D
----
P
G
-
Q
---
L
L
R
N
HLN
Q
-----
V
------
G
----------
H
TGGL
E
Q
--
V
E
M
F
---
L
L
A
-----
Y
A
V
----
R
--------
H
--------
T
I
Q
V
Y
R
L
S
K
Y
N
T
E
-------
E
F
I
T
V
Y
P
--
T
--
D
P
P
K
D
W
P
V
V
----
T
L
-
I
A
E
D
-
D
R
H
Y
N
I
P
V
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
40.44
28%
67
- C4 -
3VUO
-
?
A:
[707-765]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
D
L
S
K
A
S
I
----
P
P
-
D
---
T
L
K
----
L
-----
I
------
K
----------
E
----
T
T
--
E
K
-
T
---
F
I
D
L
S
N
E
S
Q
I
S
----
M
--------
N
--------
R
V
D
N
F
L
N
K
A
S
I
C
V
-------
F
V
E
D
I
Y
P
--
K
--
F
I
S
Y
---
M
E
----
K
Y
-
I
N
N
I
-
N
I
K
T
R
E
F
I
Q
R
C
T
N
I
N
D
N
E
K
S
I
L
I
N
S
Y
T
-
F
K
T
I
D
F
K
F
L
N
I
Q
A
I
K
N
F
F
N
S
Q
V
E
Q
V
M
K
E
M
L
S
P
Y
---------
Q
L
L
L
F
A
T
R
G
P
N
S
N
I
I
E
D
I
S
G
K
N
T
L
I
Q
Y
T
E
S
V
E
L
V
Y
G
V
N
-------
G
E
S
L
Y
L
K
S
P
N
E
T
V
E
F
S
N
N
F
F
T
N
G
L
T
N
N
F
T
I
C
F
-------------
W
L
R
F
T
G
K
D
D
D
K
T
-
R
L
I
G
N
K
V
N
N
C
G
W
E
I
Y
---
F
E
D
N
G
L
V
F
E
I
I
D
S
N
G
N
Q
E
---------
S
V
Y
L
S
N
V
I
N
N
N
W
Y
Y
I
S
-----
I
S
V
D
R
L
K
D
Q
L
L
I
F
I
N
D
K
N
V
A
N
V
S
I
E
-
Q
I
-
L
N
----------
I
Y
S
T
N
V
I
S
L
V
N
K
N
N
S
I
Y
V
E
E
L
S
V
L
D
K
P
V
A
S
E
E
V
I
R
-------------------
N
Y
F
S
Y
L
D
N
S
---------
Y
I
R
D
-------
S
S
K
S
L
L
E
Y
N
K
N
Y
Q
L
Y
N
Y
V
F
P
------------------
12
PsiBlast_PDB
39.54
24%
126
- C4 -
4EI8
-
REPX_BACC1
A:
[140-231]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
D
Y
N
F
-----
G
L
L
L
T
L
P
R
D
A
E
A
L
K
V
L
E
N
A
T
S
R
I
R
S
-
I
A
-
M
N
----------
Q
-
E
A
F
G
S
I
V
L
I
D
N
A
K
L
Y
R
K
F
E
E
E
N
P
S
A
L
A
N
E
Y
T
S
Y
-------------------
S
N
K
Y
I
A
D
A
L
---------
H
E
I
N
-------
L
V
T
S
S
F
T
P
F
S
D
T
H
F
D
A
S
E
F
A
------------------
4
PsiBlast_PDB
39.52
26%
116
- C3 -
2BIH
-
NIA_PICAN
A:
[274-361]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
S
D
D
---------
R
W
W
-
K
D
E
R
Y
A
I
Y
D
L
N
L
-----
Q
T
I
I
C
K
P
E
N
Q
Q
V
I
K
I
S
E
D
--
E
Y
E
I
A
-
G
F
-
G
Y
----------
N
G
G
G
V
-
R
I
G
R
I
------------
E
V
S
L
D
K
G
K
S
W
K
L
-------------------
A
D
I
D
Y
P
E
D
R
---------
Y
R
E
A
-------
G
Y
F
R
L
F
G
G
L
V
N
V
C
D
R
M
S
C
L
C
------------------
2
PsiBlast_PDB
39.19
26%
123
* C3 *
2BII
2
NIA_PICAN
A:
[224-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
S
D
D
---------
R
W
W
-
K
D
E
R
Y
A
I
Y
D
L
N
L
-----
Q
T
I
I
C
K
P
E
N
Q
Q
V
I
K
I
S
E
D
--
E
Y
E
I
A
-
G
F
-
G
Y
----------
N
G
G
G
V
-
R
I
G
R
I
------------
E
V
S
L
D
K
G
K
S
W
K
L
-------------------
A
D
I
D
Y
P
E
D
R
---------
Y
R
E
A
-------
G
Y
F
R
L
F
G
G
L
V
N
V
C
D
R
M
S
C
L
C
------------------
14
PsiBlast_PDB
38.56
26%
92
- C4 -
4EI9
1
REPX_BACC1
A:
[140-231]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
D
Y
N
F
-----
G
L
L
L
T
L
P
R
D
A
E
A
L
K
V
L
E
N
A
T
S
R
I
R
S
-
I
A
M
N
Q
----------
E
A
--
F
G
S
I
V
L
I
D
N
A
K
L
Y
R
K
F
E
E
E
N
P
S
A
L
A
N
E
Y
T
S
Y
-------------------
S
N
K
Y
I
A
D
A
L
---------
H
E
I
N
-------
L
V
T
S
S
F
T
P
F
S
D
T
H
F
D
A
S
E
F
A
------------------
13
PsiBlast_PDB
38.08
26%
102
- C4 -
4EI7
1
REPX_BACC1
A:
[140-231]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
D
Y
N
F
-----
G
L
L
L
T
L
P
R
D
A
E
A
L
K
V
L
E
N
A
T
S
R
I
R
S
-
I
A
M
N
Q
----------
E
A
--
F
G
S
I
V
L
I
D
N
A
K
L
Y
R
K
F
E
E
E
N
P
S
A
L
A
N
E
Y
T
S
Y
-------------------
S
N
K
Y
I
A
D
A
L
---------
H
E
I
N
-------
L
V
T
S
S
F
T
P
F
S
D
T
H
F
D
A
S
E
F
A
------------------
8
PsiBlast_PDB
35.60
26%
81
- C4 -
4ARH
6
?
A:
[58-137]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
F
----------
E
-
D
I
K
A
Y
Y
R
K
G
Y
V
T
N
V
---------
E
T
I
G
I
E
N
G
V
I
E
F
H
R
D
N
N
V
A
S
C
K
---
Y
N
Y
A
G
Y
K
I
L
T
Y
A
S
-
G
K
K
G
V
--
R
Y
L
F
E
C
K
-----
D
A
N
S
K
A
P
K
Y
V
Q
F
S
D
H
-
I
I
A
P
R
K
S
A
H
F
H
I
F
M
---
G
N
T
S
Q
Q
A
L
-
L
Q
E
M
E
N
W
P
T
Y
Y
P
---------
Y
Q
L
K
A
N
E
V
-------
V
-
D
E
M
-----
L
-----
H
-
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
34.73
26%
82
- C4 -
4AW8
8
?
A:
[58-137]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
F
----------
E
-
D
I
K
A
Y
Y
R
K
G
Y
V
T
N
V
---------
E
T
I
G
I
E
N
G
V
I
E
F
H
R
D
N
N
V
A
S
C
K
---
Y
N
Y
A
G
Y
K
I
L
T
Y
A
S
-
G
K
K
G
V
--
R
Y
L
F
E
C
K
-----
D
A
N
S
K
A
P
K
Y
V
Q
F
S
D
H
-
I
I
A
P
R
K
S
A
H
F
H
I
F
M
---
G
N
T
S
Q
Q
A
L
-
L
Q
E
M
E
N
W
P
T
Y
Y
P
---------
Y
Q
L
K
A
N
E
V
-------
V
-
D
E
M
-----
L
-----
H
-
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------