@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0393: (2015-12-01 )
MSTINNSEDKKKIIRDLVTKSIKKGGFITFDDINDKLSDENLSSDFIDDTISLLQDSGINILESSEDEEEAPSNSDDSKLDDDDALSNTTTTLVQNDDPVRVYLQDMSSVKLLSRTDEIEIAKKIESEKHNMLRAIIETSVTLKMIKAWRDDLSSGSLLLREIIDLDAIYNSDFNAIPKEESEESIEDDKDSENVSEGTKDDEYCEDDEIDSKKGNDEKENSNEDINSANLNVSILEMENDLLPKVIVALDEIITLADEALTLRKDPSGGLRYQNLYDQIWSIVLQIKLSDTAVAKITQKLYNINRSIMLEEANLISEAKKYNIDRESFLKVYADVLLRYKLEEISSLKSSENQFCFTGELKNKFVKFIDDNFEHIADTLNNIKQHIQEDNVQEFKELIKRTQKHEREVSEAKQGMIKANLRLVVSIAKKYSNRGLALLDLIQEGNIGLMKAVDKFDYKRGYKFSTYGTWWVRQSITRAIPEQSKVVRIPVHMVEIISKINRALRKLTHEMGREPTLEELSMELGMPLERIRKVMKIARDPVSLDAPTGKDDSSTFGDCIEDKRVSKPEDAAILTDLRCITTNLLATLTPKEERIIRMRFGLGKDCKEHTLEEIGCIFKVTRERIRQVESKALRKLKHPCRARKLRGFF
Atome Classification :
(36 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......--390--........400...---....410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.........530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.....-..640.......-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSTINN
S
E
D
K
K
K
I
I
R
D
L
V
T
K
S
I
KKG
G
F
I
T
FDDINDKLSDENL
S
S
D
F
I
D
D
T
I
S
L
L
Q
DSG
I
N
ILESSEDEEEAPSNSDDSKLDDDDALSNT
T
T
T
L
VQNDD
P
V
R
V
Y
L
Q
D
M
S
S
V
K
L
LSRT
D
E
I
E
I
A
K
K
I
E
S
E
K
H
N
M
L
R
A
I
I
E
T
S
V
T
L
K
M
I
K
A
W
R
DDLS
S
G
S
L
L
L
R
E
I
I
D
L
D
A
I
YNSDFNAIPKEESEESIEDDKDSENVSEGTKDDEYCEDDEIDSKKGNDEKENSNEDINSAN
L
N
V
S
I
L
EMEND
L
L
P
K
V
I
V
A
L
D
E
I
I
T
L
A
D
E
A
L
T
LRKDPSGGL
R
Y
Q
N
L
Y
D
Q
I
W
S
I
V
L
Q
I
KLS
D
T
A
V
A
K
I
T
Q
K
L
Y
NI
N
R
S
I
M
L
E
E
A
N
L
I
S
E
A
K
KYNI
D
R
E
S
F
L
K
V
Y
A
D
V
L
L
R
Y
K
L
E
E
I
S
S
L
KSSEN
Q
F
C
F
T
G
E
L
K
N
K
F
V
K
F
I
DD
N
F
E
H
I
A
D
T
L
N
N
I
K
Q
H
I
Q
E--D
N
---
V
Q
E
F
K
E
L
I
K
R
T
Q
K
H
---
E
R
E
V
S
E
A
K
Q
G
M
I
K
A
N
L
R
L
V
V
S
I
A
K
K
YSNR
G
L
A
L
L
D
L
I
Q
EGN
I
G
L
M
K
A
V
D
K
F
D
Y
KRGYKFST
Y
G
T
W
W
V
R
Q
S
I
T
R
AIPEQS
K
V
V
R
I
P
V
H
M
V
E
I
I
S
K
I
N
R
A
L
R
K
L
T
H
E
MGREP
T
L
E
E
L
--
S
M
E
LGM
P
L
E
R
I
R
K
V
M
K
IARDPVSLDAPTGKDDSS
T
F
G
D
C
I
E
DKRVSKPE
D
A
A
I
L
T
D
L
R
C
I
T
T
N
L
L
ATLTPKE
E
R
I
I
R
M
RFGLGK
D
C
K
E
H
T
L
E
E
I
G
C
I
F
K
V
T
R
E
R
I
R
Q
V
E
S
K
A
L
R
K
L
K-H
P
C
R
A
R
K
LRGFF-
58
Fugue
92.67
38%
-60
* C9 *
4LLG
-
RPOD_ECOLI
F:
[6-612]
Q
S
Q
-----------
L
K
L
L
V
T
R
G
K
E
Q
G
Y
L
T
Y
A
E
V
N
D
H
L
P
E
D
I
V
D
S
D
Q
I
E
D
I
I
Q
M
I
N
D
M
G
I
Q
V
M
G
R
T
T
D
-------------------------------
P
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
E
E
A
R
L
S
D
L
I
-------
T
G
F
V
D
D
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
T
I
K
A
T
----------------------------------------------
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
---
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
V
E
--------------------
Q
C
K
M
P
K
K
N
F
I
T
L
F
------------
T
G
N
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
---
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
---
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
--
A
E
R
M
L
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
-
T
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
S
E
V
L
R
S
F
L
D
12
PsiBlast_PDB
80.24
50%
-68
- C7 -
4LLG
-
RPOD_ECOLI
F:
[310-611]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
-
I
E
E
--
E
T
GLT
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
---
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
--
A
E
R
M
L
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
-
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
S
E
V
L
R
S
F
L
-
20
PsiBlast_PDB
79.56
50%
-67
- C7 -
4ZH3
-
?
F:
[310-611]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
-
I
E
E
--
E
T
GLT
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
---
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
--
A
E
R
M
L
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
-
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
S
E
V
L
R
S
F
L
-
11
PsiBlast_PDB
79.45
50%
-68
- C7 -
4LK1
-
RPOD_ECOLI
F:
[310-611]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
-
I
E
E
--
E
T
GLT
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
---
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
--
A
E
R
M
L
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
-
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
S
E
V
L
R
S
F
L
-
19
PsiBlast_PDB
79.43
50%
-69
- C7 -
4ZH2
-
?
F:
[310-611]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
-
I
E
E
--
E
T
GLT
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
---
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
--
A
E
R
M
L
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
-
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
S
E
V
L
R
S
F
L
-
15
PsiBlast_PDB
78.10
50%
-70
- C7 -
4YFK
-
RPOD_ECOLI
F:
[310-611]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
-
I
E
E
--
E
T
GLT
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
---
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
--
A
E
R
M
L
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
-
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
S
E
V
L
R
S
F
L
-
2
PsiBlast_PDB
78.03
50%
-78
- C7 -
4JKR
1
RPOD_ECOLI
F:
[325-626]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
-
I
E
E
--
E
T
GLT
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
---
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
--
A
E
R
M
L
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
-
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
S
E
V
L
R
S
F
L
-
16
PsiBlast_PDB
77.97
50%
-76
- C7 -
4YFN
-
RPOD_ECOLI
F:
[310-611]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
-
I
E
E
--
E
T
GLT
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
---
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
--
A
E
R
M
L
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
-
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
S
E
V
L
R
S
F
L
-
23
PsiBlast_CBE
77.84
50%
-66
- C7 -
4KN4
1
RPOD_ECOLI
Y:
[310-609]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
-
I
E
E
--
E
T
GLT
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
---
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
--
A
E
R
M
L
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
-
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
S
E
V
L
R
S
---
24
PsiBlast_CBE
77.34
50%
-67
- C7 -
4KMU
1
RPOD_ECOLI
Y:
[310-609]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
-
I
E
E
--
E
T
GLT
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
---
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
--
A
E
R
M
L
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
-
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
S
E
V
L
R
S
---
18
PsiBlast_PDB
76.89
50%
-69
- C7 -
4YG2
-
RPOA_ECOLI (first)
F:
[310-611]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
-
I
E
E
--
E
T
GLT
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
---
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
--
A
E
R
M
L
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
-
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
S
E
V
L
R
S
F
L
-
13
PsiBlast_PDB
76.60
50%
-59
- C7 -
4MEX
-
RPOD_ECOLI
F:
[310-611]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
-
I
E
E
--
E
T
GLT
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
---
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
--
A
E
R
M
L
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
-
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
S
E
V
L
R
S
F
L
-
17
PsiBlast_PDB
76.41
50%
-70
- C7 -
4YFX
-
RPOD_ECOLI
F:
[310-609]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
-
I
E
E
--
E
T
GLT
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
---
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
--
A
E
R
M
L
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
-
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
S
E
V
L
R
S
---
3
PsiBlast_PDB
76.34
50%
-69
- C7 -
4YLN
-
RPOD_ECOLI
F:
[325-626]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
-
I
E
E
--
E
T
GLT
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
---
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
--
A
E
R
M
L
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
-
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
S
E
V
L
R
S
F
L
-
14
PsiBlast_PDB
75.76
50%
-56
- C7 -
4MEY
-
RPOD_ECOLI
F:
[310-611]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
-
I
E
E
--
E
T
GLT
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
---
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
--
A
E
R
M
L
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
-
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
S
E
V
L
R
S
F
L
-
22
PsiBlast_CBE
75.71
50%
-70
- C7 -
4YLP
1
RPOD_ECOLI
L:
[325-626]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
-
I
E
E
--
E
T
GLT
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
---
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
--
A
E
R
M
L
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
-
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
S
E
V
L
R
S
F
L
-
5
PsiBlast_PDB
74.81
50%
-65
- C7 -
4YLP
1
RPOD_ECOLI
F:
[325-626]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
-
I
E
E
--
E
T
GLT
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
---
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
--
A
E
R
M
L
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
-
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
S
E
V
L
R
S
F
L
-
4
PsiBlast_PDB
74.50
50%
-66
- C7 -
4YLO
-
RPOD_ECOLI
F:
[325-626]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
S
D
T
W
F
N
A
A
I
A
M
N
K
P
W
S
E
K
L
H
D
V
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
-
I
E
E
--
E
T
GLT
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
---
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
--
A
E
R
M
L
M
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
T
P
I
G
D
D
E
D
S
H
L
G
D
F
I
E
D
T
T
L
E
L
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
G
I
D
M
N
T
-
D
Y
T
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
-
H
P
S
R
S
E
V
L
R
S
F
L
-
41
PsiBlast_CBE
71.14
50%
-70
- C7 -
4G7O
2
?
P:
[163-442]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
P
G
L
K
E
T
L
D
P
K
T
V
E
--
E
I
---
D
Q
K
L
K
S
L
P
K
E
H
K
R
Y
LHI
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
AE
A
M
G
P
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
-
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
-
44
PsiBlast_CBE
70.94
50%
-66
- C7 -
4G7H
3
?
F:
[163-442]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
P
G
L
K
E
T
L
D
P
K
T
V
E
--
E
I
---
D
Q
K
L
K
S
L
P
K
E
H
K
R
Y
L
H
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
-
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
-
38
PsiBlast_CBE
70.86
50%
-67
- C7 -
4OIN
3
?
F:
[163-442]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
P
G
L
K
E
T
L
D
P
K
T
V
E
--
E
I
---
D
Q
K
L
K
S
L
P
K
E
H
K
R
Y
L
H
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
-
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
-
26
PsiBlast_CBE
70.44
50%
-66
- C7 -
4Q4Z
2
?
F:
[143-422]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
P
G
L
K
E
T
L
D
P
K
T
V
E
--
E
I
---
D
Q
K
L
K
S
L
P
K
E
H
K
R
Y
L
H
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
-
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
-
43
PsiBlast_CBE
70.34
50%
-66
- C7 -
4G7H
4
?
P:
[163-442]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
P
G
L
K
E
T
L
D
P
K
T
V
E
--
E
I
---
D
Q
K
L
K
S
L
P
K
E
H
K
R
Y
LHI
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
AE
A
M
G
P
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
-
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
-
40
PsiBlast_CBE
69.85
50%
-65
- C7 -
4G7Z
2
?
F:
[163-442]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
P
G
L
K
E
T
L
D
P
K
T
V
E
--
E
I
---
D
Q
K
L
K
S
L
P
K
E
H
K
R
Y
L
H
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
-
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
-
39
PsiBlast_CBE
69.60
50%
-64
- C7 -
4G7Z
2
?
P:
[163-442]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
P
G
L
K
E
T
L
D
P
K
T
V
E
--
E
I
---
D
Q
K
L
K
S
L
P
K
E
H
K
R
Y
LHI
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
AE
A
M
G
P
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
-
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
-
36
PsiBlast_CBE
69.59
50%
-63
- C7 -
4OIP
3
?
F:
[163-442]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
P
G
L
K
E
T
L
D
P
K
T
V
E
--
E
I
---
D
Q
K
L
K
S
L
P
K
E
H
K
R
Y
L
H
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
-
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
-
35
PsiBlast_CBE
69.58
50%
-63
- C7 -
4OIQ
3
?
F:
[163-442]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
P
G
L
K
E
T
L
D
P
K
T
V
E
--
E
I
---
D
Q
K
L
K
S
L
P
K
E
H
K
R
Y
L
H
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
-
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
-
37
PsiBlast_CBE
69.55
50%
-66
- C7 -
4OIO
2
?
F:
[163-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
P
G
L
K
E
T
L
D
P
K
T
V
E
--
E
I
---
D
Q
K
L
K
S
L
P
K
E
H
K
R
Y
L
H
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
-
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
--
42
PsiBlast_CBE
69.34
50%
-66
- C7 -
4G7O
2
?
F:
[163-442]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
P
G
L
K
E
T
L
D
P
K
T
V
E
--
E
I
---
D
Q
K
L
K
S
L
P
K
E
H
K
R
Y
L
H
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
-
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
-
34
PsiBlast_CBE
69.31
50%
-64
- C7 -
4OIR
4
?
F:
[163-442]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
P
G
L
K
E
T
L
D
P
K
T
V
E
--
E
I
---
D
Q
K
L
K
S
L
P
K
E
H
K
R
Y
L
H
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
I
G
D
E
K
D
S
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
-
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
-
25
PsiBlast_CBE
67.87
50%
-64
- C7 -
4Q5S
1
?
F:
[143-422]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
P
G
L
K
E
T
L
D
P
K
T
V
E
--
E
I
---
D
Q
K
L
K
S
L
P
K
E
H
K
R
Y
L
H
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
P
V
S
L
E
T
P
-------
F
Y
G
D
F
I
P
D
E
H
L
P
S
P
V
D
A
A
T
Q
S
L
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
G
L
-
I
D
G
R
E
H
T
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
L
R
D
F
L
-
47
PsiBlast_CBE
54.88
57%
-70
- C7 -
4KI2
1
SIGA_THEAQ
B:
[98-239]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
R
Y
L
H
I
---
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
S
Y
E
E
I
AE
A
M
G
P
G
W
D
A
K
R
V
E
E
T
L
K
I
A
-----------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
48.21
57%
-24
- C7 -
3UGP
1
SIGA_THEAQ
A:
[98-184]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
R
Y
L
H
I
---
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
47.98
57%
-28
- C7 -
3UGO
1
SIGA_THEAQ
A:
[98-184]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
R
Y
L
H
I
---
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
HHSearch
46.43
55%
-30
- C7 -
3UGO
1
SIGA_THEAQ
A:
[98-184]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
R
Y
L
H
I
A
R
E
G
-------
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
45.22
57%
-26
- C7 -
4KI2
1
SIGA_THEAQ
A:
[98-183]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
R
Y
L
H
I
---
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------