@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0396: (2015-12-01 )
MAIILLDTKTINRIAAGEVIERPASVVKELVENAIDAGSSEIEIKIESGGCNLITITDDGGGIEKSDLELAFMRHATSKLSDSELIEIKHLGFRGEALSSIAAVSRIKLSSKANGASEAWSISYEGGEKIGELIPYSLPQGTHIEVRDLFFATPNRLKFLKTERAEIQSIVDIVNNLAMINYSIGFTLTSGSKKPLKYAKQTSLFSRLCEVEEEFQDNSLEINEEEDGVRLTGHICKPTVNRGKSDMIYTFVNGRPIKDNLLVSAIRYAYHDFIPSNRYPFATLHLEIPYDQIDVNVHPNKSEVRFQNKRLIYEIVRRGLIKALSTRTGNSAVSNIDRSRCQGIGKETSGLPFDVSESQGNDNHINNGKSRETKSERELYERRPNPFENRLMKESNSPSVGKKDLSERSVLFDSGIQKSLSQAKTVVLEREQIDLIENHPLGFARCQVYNTYIIAEARGKLIIVDQHAAHERLVYECLKQKSSIKRQKLLLSEVVEIKNQAGMEMVEVYKDKLFEMGFDIQINSENKVIVKEIPAILGTIDVKEMLIDIVDRLMEIEDMLPIEDKVNKILATIACHGSIRAGRTMKLEEMNVLLRQMEETPYSGQCNHGRPTHIEMKLSDIEKLFERR
Atome Classification :
(21 SA)
-----.........10.......-.20--.........30........40........50........60........70........80...-....---..90........100.......110.......120......-.130.......---140.......150......-.160........170.......180.....---..190--..-----....-------------------..-------.---200--------.--------.....-----..210.-----.......220..------------.-..--..230...--....-240.---..-..--....250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480---..---.-.....490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----
M
A
I
I
L
LDTK
T
I
N
R
I
A
A
G
E
-
V
I
---
E
R
P
A
S
V
V
K
E
L
V
E
N
A
I
DAGS
S
E
I
E
I
K
I
ESGG
C
N
L
I
T
I
TDDGGGIE
K
S
D
L
E
L
A
F
M
R
H
A
T
SKL-SDS-
E
L
I
E
---
I
K
HLGF
R
G
E
A
L
S
S
I
A
A
V
S
R
I
K
LSSKANGAS
E
A
W
S
I
S
YEG
G
E
-
K
I
G
E
LIPYSLP---QG
T
H
I
E
V
R
D
L
F
FATPN
R
L
K
-
F
L
K
-
T
E
R
A
E
I
Q
S
I
V
D
I
V
NN
L
A
M
I
N
Y
S
I
G
F
T
---LTS----GS-----KK
P
L
-------------------
K
Y
-------
A
---
K
Q
---------
T
--------
S
L
F
S
R
-----
L
C
E
V
-
E
-----
E
E
FQDNS
L
E
INE------------E-ED--
G
V
R
L
TGHI--CKPT-V--N---RG-KS--
D
M
I
Y
T
FVNGRPI
K
D
N
L
L
V
S
A
I
R
Y
A
Y
H
DFIPSNRY
P
F
A
T
L
H
L
E
IPY
D
Q
I
D
V
N
VHPNKS
E
V
R
FQ
N
K
R
L
I
Y
E
I
V
R
R
G
L
I
K
A
L
STRTGN
S
A
V
S
NI
D
R
S
R
C
QGIGKETSGLPFDVSESQGNDNHINNGKSRE
T
K
S
E
R
E
L
Y
E
RRPN
P
F
E
N
R
L
MKESNSPSV
G
K
K
D
L
S
E
R
S
V
L
F
D
S
G
I
Q
K
S
L
S
Q
A
K
T
V
V
L
E
R
E
Q
I
D
L
IENHPL
G
F
A
R
C
Q
V
Y
N
T
Y
I
I
A
EARG
K
L
I
I
V
DQHA
A
H
E
R
L
V
Y
E
C
L
K
Q
K
----
S
S
---
I
-
K
R
Q
K
L
L
L
S
E
V
V
E
I
K
N
QA
G
M
E
M
V
E
V
Y
K
D
K
L
F
EMG
F
D
I
Q
INSENK
V
I
V
K
E
I
P
A
I
L
G
T
I
D
V
K
E
M
L
I
D
I
V
D
R
L
M
E
I
E
D
ML
P
I
E
D
K
V
N
K
I
L
A
T
I
ACHGSIRAG
R
T
M
K
L
E
E
M
N
V
L
L
R
Q
M
E
ETPYSGQCNHGRP
T
H
I
E
M
K
L
S
D
I
E
K
L
FERR
43
Fugue
89.67
42%
-76
- C2 -
1B63
4
MUTL_ECOLI
A:
[1-333]
---SH
M
P
I
Q
V
L
P
P
Q
L
A
N
Q
I
A
A
G
-
E
V
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
R
H
A
T
S
K
I
A
S
L
D
-
D
L
E
A
---
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
A
E
Q
Q
E
A
W
Q
A
Y
A
E
G
R
D
M
N
V
-
T
V
K
P
A
A
H
P
---
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
-R
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
N
---
L
S
H
----
N
-------
G
----------------------
K
-------
I
---
V
R
---------
Q
Y
R
A
VPEGG
Q
K
E
R
R
-----
L
G
A
I
C
G
-----
T
A
F
L
E
Q
A
L
A
I
E
W
------------
Q
-
H
G
--
D
L
T
L
R
G
W
V
--
A
D
P
N
-----HTT
P
A
-
L
A
--
E
I
Q
Y
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
Q
G
V
L
S
V
L
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
88.82
42%
-71
- C2 -
1B63
4
MUTL_ECOLI
A:
[3-333]
-----
M
P
I
Q
V
L
P
P
Q
L
A
N
Q
I
A
A
G
E
-
V
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
R
H
A
T
S
K
I
-
A
S
L
D
D
L
E
A
---
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
A
E
Q
Q
E
A
W
Q
A
Y
A
E
G
R
D
-
M
N
V
T
V
K
P
A
A
H
P
---
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
R
-
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
N
---
L
S
H
----
N
G
-----
K
I
V
R
-------------------
Q
Y
-------
R
A
VP
E
G
---------
G
--------
Q
K
E
R
R
-----
L
G
A
I
C
G
-----
T
A
F
L
E
Q
A
L
A
I
E
W
------------
Q
-
H
G
--
D
L
T
L
R
G
W
V
--
A
D
P
N
-
H
T-
T
---
P
A
-
L
A
--
E
I
Q
Y
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
Q
G
V
L
S
V
L
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
88.52
40%
-77
- C2 -
1NHI
5
MUTL_ECOLI
A:
[3-332]
-----
M
P
I
Q
V
L
P
P
Q
L
A
N
Q
I
A
A
G
E
-
V
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
R
H
A
T
S
K
I
-
A
S
L
-
D
D
L
E
A
--
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
A
E
Q
Q
E
A
W
Q
A
Y
A
E
G
R
D
-
M
N
V
T
V
K
P
A
A
H
P
---
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
R
-
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
N
---
L
S
H
----
N
G
-----
K
I
V
R
-------------------
Q
Y
R
A
V
P
EG-
G
---
Q
K
---------
E
--------
R
R
L
G
A
-----
I
C
G
T
--------
A
F
L
E
Q
A
L
A
I
E
W
------------
Q
-
H
G
--
D
L
T
L
R
G
W
V
--
A
D
P
N
H
T
--
T
---
P
A
-
L
A
--
E
I
Q
Y
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
Q
G
V
L
S
V
L
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
87.93
40%
-73
- C2 -
1B63
4
MUTL_ECOLI
A:
[3-332]
-----
M
P
I
Q
V
L
P
P
Q
L
A
N
Q
I
A
A
G
E
-
V
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
R
H
A
T
S
K
I
-
A
S
L
-
D
D
L
E
A
--
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
A
E
Q
Q
E
A
W
Q
A
Y
A
E
G
R
D
-
M
N
V
T
V
K
P
A
A
H
P
---
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
R
-
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
N
---
L
S
H
----
N
G
-----
K
I
V
R
-------------------
Q
Y
R
A
VPEG-
G
---
Q
K
---------
E
--------
R
R
L
G
A
-----
I
C
G
T
--------
A
F
L
E
Q
A
L
A
I
E
W
------------
Q
-
H
G
--
D
L
T
L
R
G
W
V
--
A
D
P
N
H
T
--
T
---
P
A
-
L
A
--
E
I
Q
Y
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
Q
G
V
L
S
V
L
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
87.57
40%
-75
- C2 -
1NHJ
3
MUTL_ECOLI
A:
[3-332]
-----
M
P
I
Q
V
L
P
P
Q
L
A
N
Q
I
A
A
G
E
-
V
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
R
H
A
T
S
K
I
-
A
S
L
-
D
D
L
E
A
--
I
I
S
L
G
F
R
G
E
A
L
P
S
I
S
S
V
S
R
L
T
L
T
S
R
T
A
E
Q
Q
E
A
W
Q
A
Y
A
E
G
R
D
-
M
N
V
T
V
K
P
A
A
H
P
---
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
R
-
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
N
---
L
S
H
----
N
G
-----
K
I
V
R
-------------------
Q
Y
R
A
VPEG-
G
---
Q
K
---------
E
--------
R
R
L
G
A
-----
I
C
G
T
--------
A
F
L
E
Q
A
L
A
I
E
W
------------
Q
-
H
G
--
D
L
T
L
R
G
W
V
--
A
D
P
N
H
T
--
T
---
P
A
-
L
A
--
E
I
Q
Y
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
Q
G
V
L
S
V
L
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
85.36
40%
-75
- C2 -
1NHH
8
MUTL_ECOLI
A:
[3-332]
-----
M
P
I
Q
V
L
P
P
Q
L
A
N
Q
I
A
A
G
E
-
V
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
R
H
A
T
S
K
I
-
A
S
L
-
D
D
L
E
A
--
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
A
E
Q
Q
E
A
W
Q
A
Y
A
E
G
R
D
-
M
N
V
T
V
K
P
A
A
H
P
---
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
R
-
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
N
---
L
S
H
----
N
G
-----
K
I
V
R
-------------------
Q
Y
R
A
V
P-------
Q
K
---------
E
--------
R
R
L
G
A
-----
I
C
G
T
--------
A
F
L
E
Q
A
L
A
I
E
W
------------
Q
-
H
G
--
D
L
T
L
R
G
W
V
--
A
D
P
N
H
T
--
T
---
P
A
-
L
A
--
E
I
Q
Y
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
--
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
Q
G
V
L
S
V
L
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
84.29
41%
-83
- C2 -
5AKC
-
?
C:
[40-350]
-------------------------
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
S
G
I
K
K
D
E
L
A
L
A
L
A
------
I
-
A
S
L
-
D
D
L
E
A--
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
A
E
Q
Q
E
A
W
Q
A
Y
A
-------
V
T
V
K
P
A
A
H
P
---
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
R
-
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
N
---
L
S
H
----
N
G
-----
K
I
V
R
-------------------
Q
Y
RAVPEGG
Q
---
K
E
---------
R
--------
R
L
G
A
I
-----
L
G
T
A
---------
F
L
E
Q
A
L
A
I
E
W
------------
Q
-
H
G
--
D
L
T
L
R
G
W
V
--
A
D
P
N
H
T
--
T
---
P
A
-
L
A
--
E
I
Q
Y
F
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
Y
E
D
K
L
G
A
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
---------------
S
R
L
V
H
D
F
I
Y
Q
G
V
L
S
V
L
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
83.67
41%
-86
- C2 -
5AKB
-
?
C:
[40-350]
-------------------------
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
S
G
I
K
K
D
E
L
A
L
A
L
A
------
I
-
A
S
L
-
D
D
L
E
A--
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
A
E
Q
Q
E
A
W
Q
A
Y
A
-------
V
T
V
K
P
A
A
H
P
---
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
R
-
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
N
---
L
S
H
----
N
G
-----
K
I
V
R
-------------------
Q
Y
RAVPEGG
Q
---
K
E
---------
R
--------
R
L
G
A
I
-----
L
G
T
A
---------
F
L
E
Q
A
L
A
I
E
W
------------
Q
-
H
G
--
D
L
T
L
R
G
W
V
--
A
D
P
N
H
T
--
T
---
P
A
-
L
A
--
E
I
Q
Y
F
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
Y
E
D
K
L
G
A
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
---------------
S
R
L
V
H
D
F
I
Y
Q
G
V
L
S
V
L
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
82.14
40%
-87
- C2 -
1BKN
-
MUTL_ECOLI
A:
[20-330]
-------------------------
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
------
I
-
A
S
L
-
D
D
L
E
A--
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
A
E
Q
Q
E
A
W
Q
A
Y
A
-------
V
T
V
K
P
A
A
H
P
---
V
G
T
T
L
E
V
L
D
---------------
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
N
---
L
S
H
----
N
G
-----
K
I
V
R
-------------------
Q
Y
R
A
V
P
EG-
G
---
Q
K
---------
E
--------
R
R
L
G
A
-----
I
C
G
T
--------
A
F
L
E
Q
A
L
A
I
E
W
------------
Q
-
H
G
--
D
L
T
L
R
G
W
V
--
A
D
P
N
H
T
--
T
---
P
A
-
L
A
--
E
I
Q
Y
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
---------------
S
R
L
V
H
D
F
I
Y
Q
G
V
L
S
V
L
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
81.76
41%
-80
- C2 -
5AKD
-
?
C:
[40-350]
-------------------------
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
S
G
I
K
K
D
E
L
A
L
A
L
A
------
I
-
A
S
L
-
D
D
L
E
A--
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
A
E
Q
Q
E
A
W
Q
A
Y
A
-------
V
T
V
K
P
A
A
H
P
---
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
R
-
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
N
---
L
S
H
----
N
G
-----
K
I
V
R
-------------------
Q
Y
RAVPEGG
Q
---
K
E
---------
R
--------
R
L
G
A
I
-----
L
G
T
A
---------
F
L
E
Q
A
L
A
I
E
W
------------
Q
-
H
G
--
D
L
T
L
R
G
W
V
--
A
D
P
N
H
T
--
T
---
P
A
-
L
A
--
E
I
Q
Y
F
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
Y
E
D
K
L
G
A
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
---------------
S
R
L
V
H
D
F
I
Y
Q
G
V
L
S
V
L
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
80.21
40%
-60
- C- -
1B62
2
MUTL_ECOLI
A:
[7-336]
-----
M
P
I
Q
V
L
P
P
Q
L
A
N
Q
I
A
A
G
E
-
V
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
R
H
A
T
S
K
I
-
A
S
L
-
D
D
L
E
A
--
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
A
E
Q
Q
E
A
W
Q
A
Y
A
E
G
R
D
-
M
N
V
T
V
K
P
A
A
H
P
---
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
R
-
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
N
---
L
S
H
----
N
G
-----
K
I
V
R
-------------------
Q
Y
R
A
V
P
EG-
G
---
Q
K
---------
E
--------
R
R
L
G
A
-----
I
C
G
T
--------
A
F
L
E
Q
A
L
A
I
E
W
------------
Q
-
H
G
--
D
L
T
L
R
G
W
V
--
A
D
P
N
H
T
--
T
---
P
A
-
L
A
--
E
I
Q
Y
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
-
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
Q
G
V
L
S
V
L
Q
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
76.99
28%
-81
- C2 -
3H4L
2
PMS1_YEAST
A:
[14-354]
---------------
V
H
R
I
T
S
G
Q
-
V
I
---
T
D
L
T
T
A
V
K
E
L
V
D
N
S
I
D
A
N
A
N
Q
I
E
I
I
F
K
D
Y
G
L
E
S
I
E
C
S
D
N
G
D
G
I
D
P
S
N
Y
E
F
L
A
L
K
H
Y
T
----------
A
K
---
V
Q
T
L
G
F
R
G
E
A
L
S
S
L
C
G
I
A
K
L
S
V
I
T
-
T
T
S
P
P
K
A
D
K
L
E
Y
D
M
V
G
-
H
I
T
S
K
T
T
T
S
R
N
---
K
G
T
T
V
L
V
S
Q
L
F
H
N
L
P
V
R
Q
K
E
F
S
K
-
T
F
K
R
Q
F
T
K
C
L
T
V
I
Q
G
Y
A
I
I
N
A
A
I
K
F
S
V
W
N
I
T
P
----
K
G
-----
K
K
N
L
-------------------
I
L
-------
S
---
T
M
R
NSS
M
R
K
N
I
S
--------
S
V
F
G
A
GGMRG
L
E
E
V
-
D
L
V
L
D
L
N
P
F
K
N
R
M
L
--------------------DY
K
I
R
V
K
G
Y
I
--
S
Q
N
S
-
F
--
G
---
C
G
-
R
N
SK
D
R
Q
F
I
Y
V
N
K
R
P
V
E
Y
S
T
L
L
K
C
C
N
E
V
Y
K
T
F
-
N
N
V
Q
F
P
A
V
F
L
N
L
E
L
P
M
S
L
I
D
V
N
V
T
P
D
K
R
V
I
L
L
H
N
E
R
A
V
I
D
I
F
K
T
T
L
S
D
Y
Y
N
R
Q
E
L
A
L
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
75.43
27%
-71
* C2 *
3H4L
2
PMS1_YEAST
A:
[13-364]
--------------
D
V
H
R
I
T
S
G
Q
-
V
I
---
T
D
L
T
T
A
V
K
E
L
V
D
N
S
I
D
A
N
A
N
Q
I
E
I
I
F
K
D
Y
G
L
E
S
I
E
C
S
D
N
G
D
G
I
D
P
S
N
Y
E
F
L
A
L
K
H
Y
T
----------
A
K
---
V
Q
T
L
G
F
R
G
E
A
L
S
S
L
C
G
I
A
K
L
S
V
I
T
T
T
S
P
-
P
K
A
D
K
L
E
Y
D
M
V
G
-
H
I
T
S
K
T
T
T
S
R
N
---
K
G
T
T
V
L
V
S
Q
L
F
H
N
L
P
V
R
Q
K
-
E
F
S
K
T
F
K
R
Q
F
T
K
C
L
T
V
I
Q
G
Y
A
I
I
N
A
A
I
K
F
S
---
V
W
N
----
I
T
PK
G
K
K
N
L
I
L
-------------------
S
T
-------
M
---
R
N
---------
S
--------
S
M
R
K
N
-----
I
S
S
V
F
G
-----
A
G
G
M
R
G
L
E
E
V
D
L
V
L
D
LNPFKNRML--
D
Y
--
K
I
R
V
K
G
Y
I
--
S
Q
N
S
-
F
GC
G
---
R
N
-
S
K
--
D
R
Q
F
I
Y
V
N
K
R
P
V
E
Y
S
T
L
L
K
C
C
N
E
V
Y
K
T
F
-
N
N
V
Q
F
P
A
V
F
L
N
L
E
L
P
M
S
L
I
D
V
N
V
T
P
D
K
R
V
I
L
L
H
N
E
R
A
V
I
D
I
F
K
T
T
L
S
D
Y
Y
N
R
Q
E
L
A
L
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
71.17
27%
-80
- C2 -
1EA6
2
PMS2_HUMAN
A:
[27-360]
-------------------
C
S
G
Q
-
V
V
---
L
S
L
S
T
A
V
K
E
L
V
E
N
S
L
D
A
G
A
T
N
I
D
L
K
L
K
D
Y
G
V
D
L
I
E
V
S
D
N
G
C
G
V
E
E
E
N
F
E
G
L
T
L
---------------------------
E
A
L
S
S
L
C
A
L
S
D
V
T
I
S
T
C
H
A
S
A
K
V
G
T
R
L
M
F
D
H
N
G
-
K
I
I
Q
K
T
P
Y
P
R
P
---
R
G
T
T
V
S
V
Q
Q
L
F
S
T
L
P
V
R
H
K
E
F
Q
R
-
N
I
K
K
E
Y
A
K
M
V
Q
V
L
H
A
Y
C
I
I
S
A
G
I
R
V
S
---
C
T
N
Q
L
GQ
G
K
-----
R
Q
P
V
VCTGGSPS
I
K
E
N
I
G
S
V
FG
Q
K
Q
-------
L
---
Q
S
---------
L
--------
I
P
F
V
Q
-----
L
P
P
S
-
D
-----
S
V
C
E
E
Y
G
L
S
C
S
D
------------
A
L
H
N
--
L
F
Y
I
S
G
F
I
S
Q
C
T
H
G
-
V
--
G
---
R
S
-
S
T
--
D
R
Q
F
F
F
I
N
R
R
P
C
D
P
A
K
V
C
R
L
V
N
E
V
Y
H
M
Y
-
N
R
H
Q
Y
P
F
V
V
L
N
I
S
V
D
S
E
C
V
-----------
L
L
Q
E
E
K
L
L
L
A
V
L
K
T
S
L
I
G
M
F
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
69.88
27%
-85
- C2 -
1H7U
2
PMS2_HUMAN
A:
[31-360]
------------------------
V
V
---
L
S
L
S
T
A
V
K
E
L
V
E
N
S
L
D
A
G
A
T
N
I
D
L
K
L
K
D
Y
G
V
D
L
I
E
V
S
D
N
G
C
G
V
E
E
E
N
F
E
G
L
T
L
K
-------------------------
G
E
A
L
S
S
L
C
A
L
S
D
V
T
I
S
T
C
H
A
S
A
K
V
G
T
R
L
M
F
D
H
N
G
-
K
I
I
Q
K
T
P
Y
P
R
P
---
R
G
T
T
V
S
V
Q
Q
L
F
S
T
L
P
V
R
H
K
E
F
Q
R
-
N
I
K
K
E
Y
A
K
M
V
Q
V
L
H
A
Y
C
I
I
S
A
G
I
R
V
S
---
C
T
N
Q
L
GQ
G
K
-----
R
Q
P
V
V
CTGGSPS
I
K
E
N
I
G
S
V
FG
Q
K
Q
-------
L
---
Q
S
---------
L
--------
I
P
F
V
Q
-----
L
P
P
S
-
D
-----
S
V
C
E
E
Y
G
L
S
C
S
D
------------
A
L
H
N
--
L
F
Y
I
S
G
F
I
S
Q
C
T
H
G
-
V
--
G
---
R
S
-
S
T
--
D
R
Q
F
F
F
I
N
R
R
P
C
D
P
A
K
V
C
R
L
V
N
E
V
Y
H
M
Y
-
N
R
H
Q
Y
P
F
V
V
L
N
I
S
V
D
S
E
C
V
D
I
N
------
Q
I
L
L
Q
E
E
K
L
L
L
A
V
L
K
T
S
L
I
G
M
F
D
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
57.09
46%
-59
- C2 -
1B63
4
MUTL_ECOLI
A:
[3-218]
-----
M
P
I
Q
V
L
P
P
Q
L
A
N
Q
I
A
A
G
E
-
V
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
R
H
A
T
S
K
I
A
S
L
D
-
D
L
E
A
---
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
A
E
Q
Q
E
A
W
Q
A
Y
A
E
G
R
D
-
M
N
V
T
V
K
P
A
A
H
P
---
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
R
-
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
N
---
L
S
H
----
N
G
-----
K
I
V
R
-------------------
Q
Y
R
A
VPEG-
G
---
Q
K
---------
E
--------
R
R
L
G
A
-----
I
C
G
T
-
A
-----
F
L
E
Q
A
L
A
I
E
W
Q
H
------------
G
-
D
L
--
T
L
R
G
W
V
A
D
--
P
N
H
T
-
T
--
P
---
A
L
-
A
E
--
I
Q
Y
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
Q
G
V
L
S
V
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
53.24
38%
-86
- C1 -
3NCV
-
MUTL_NEIG1
A:
[463-654]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
P
L
G
F
A
I
A
Q
L
L
G
I
Y
I
L
A
Q
A
E
D
S
L
L
L
I
D
M
H
A
A
A
E
R
V
N
Y
E
K
M
K
R
Q
----
R
Q
E
N
G
N
L
Q
S
Q
H
L
L
I
P
V
T
F
A
A
S
H
E
E
-
C
A
A
L
A
D
H
A
E
T
L
A
G
F
G
L
E
L
S
D
M
G
G
N
T
L
A
V
R
A
A
P
V
M
L
G
K
S
D
V
V
S
L
A
R
D
V
L
G
E
L
A
Q
V
G
-----
A
S
H
E
N
R
I
L
A
T
M
S
C
H
G
S
I
R
A
G
R
R
L
T
L
P
E
M
N
A
L
L
R
D
M
E
N
T
P
R
S
N
Q
C
N
H
G
R
P
T
W
V
K
L
T
L
K
E
L
D
T
L
F
---
13
PsiBlast_PDB
52.44
38%
-85
- C1 -
3NCV
-
MUTL_NEIG1
A:
[466-654]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
G
F
A
I
A
Q
L
L
G
I
Y
I
L
A
Q
A
E
D
S
L
L
L
I
D
M
H
A
A
A
E
R
V
N
Y
E
K
M
K
R
Q
R
Q
E
N
G
N
---
L
-
Q
S
Q
H
L
L
I
P
V
T
F
A
A
S
H
E
E
C
A
A
L
A
D
-
H
A
E
T
L
A
G
F
G
L
E
L
S
D
M
G
G
N
T
L
A
V
R
A
A
P
V
M
L
G
K
S
D
V
V
S
L
A
R
D
V
L
G
E
L
A
Q
V
G
-----
A
S
H
E
N
R
I
L
A
T
M
S
C
H
G
S
I
R
A
G
R
R
L
T
L
P
E
M
N
A
L
L
R
D
M
E
N
T
P
R
S
N
Q
C
N
H
G
R
P
T
W
V
K
L
T
L
K
E
L
D
T
L
F
---
46
Fugue
50.21
45%
-48
- C2 -
1B63
4
MUTL_ECOLI
A:
[1-204]
SHMPI
Q
---
V
L
P
P
Q
L
A
N
Q
I
A
A
G
----
E
V
V
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
R
H
A
T
S
K
I
-
A
S
L
-
D
D
L
E
A
II--
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
A
E
Q
Q
E
A
W
Q
A
Y
A
E
G
R
D
-
M
N
V
-
T
-
V
K
P
A
-
A
H
P
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
-R
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
N
---
L
S
H
----
N
-----------------------------
G
K
-------
I
---
V
R
---------
Q
--------
Y
R
A
V
P
-----
E
G
G
Q
-
K
-----
E
R
R
L
G
A
I
C
G
T
A
F
------------
L
-
E
Q
--
A
L
A
I
E
W
Q
H
--
G
D
L
T
-
L
--
R
---
G
W
-
V
A
--
D
P
N
H
T
T
P
A
L
A
E
I
Q
Y
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
Q
G
V
L
S
V
L
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
49.73
33%
-86
- C2 -
1B63
3
MUTL_ECOLI
A:
[219-333]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
---------
T
--------
A
F
L
E
Q
-----
A
L
A
I
-
E
-----
W
Q
H
------------------------
G
--
D
L
T
L
R
G
W
V
--
A
D
P
N
H
T
--
T
---
P
A
-
L
A
--
E
I
Q
Y
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
Q
G
V
L
S
V
L
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
46.91
34%
-69
- C2 -
1B63
3
MUTL_ECOLI
A:
[219-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-----
T
A
F
L
E
Q
A
L
A
I
E
W
------------
Q
-
H
G
--
D
L
T
L
R
G
W
V
--
A
D
P
N
-
H
--
T
---
T
P
A
L
A
--
E
I
Q
Y
C
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
Q
G
V
L
S
V
L
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------