@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0408: (2015-12-01 )
MSFLIVANWKMNGTRSLFVNFIGKLNDKSNEITSKLVICPPFTSLPGNIELNSNISIGAQNCHYKKSGSYTGEISAEMLKELGCTYVILGHSERTHETNGEIKLKSETAIESGLHPIICVGENLEDRESSKTKEVVEYQCKSRLPIHGEYTVAYEPIWAIGTGHVPSNNAIAEVIEVIQSYTSKKHVIYGGSVSLENIENLSNILNLSGVLIGSASLDFDRFHKIVQQVEKAY
Atome Classification :
(61 SA)
--.........10...---.....20.....---...30.---...-.....40--.....-.-..50-.-----.----..-.....60........70........80........90....---.---...100.......110........120.......130.......140---.---.---..-----.-----.-----.-----.-----.-----150-.-----........160..--.----....170--......---------.180--------.---------.---------.------.---------.---------.----------.--.190.......200.......210.......220.......230.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--
M
S
F
L
I
V
A
NWKMNG
T
---
R
S
L
F
V
N
F
I
G
KLN---DKSN-E---
I
T
S
-
K
L
V
ICPP--FTSLP-G-
N
I
E
--L-----N----S
N
-
I
S
IGAQN
C
H
YKKSGSYTG
E
I
S
A
E
M
L
K
ELG
C
T
Y
V
I
LGHSERT---H---ETNG
E
I
K
LK
S
E
T
A
I
-ESGL
H
P
I
I
C
VGENLEDRESS
K
T
K
E
V
V
E
Y
Q
C
-----K---S---RL-----P-----I-----H-----G-----
E
-----
Y
---
T
-----
V
A
YE
P
I
W
A
IGTGH--V----PSN
N
A
I
A
--
E
V
I
E
V
I
---------
Q
S
Y
---------T---------S---------K------
K
---------
H
---------
V
----------
I
--YGGSV
S
L
E
N
I
E
N
L
S
N
I
L
N
L
S
G
V
L
IGSASL
D
F
D
R
F
H
K
I
V
Q
Q
V
E
KAY
1
PsiBlast_PDB
93.49
39%
-98
- C5 -
4OHQ
-
TPIC_ARATH
A:
[7-249]
----
F
F
V
G
G
N
W
K
C
N
G
T
---
K
D
S
I
A
K
L
I
S
D
L
N
---
S
A
T
L
-
E
---
A
D
V
-
D
V
V
V
S
P
P
--
F
V
Y
I
D
-
Q
V
K
S
S
--
L
-----
T
----
D
R
-
I
D
I
S
G
Q
N
S
W
V
G
K
G
G
A
F
T
G
E
I
S
V
E
Q
L
K
D
L
G
C
K
W
V
I
L
G
H
S
E
R
R
---
H
VIG
E
K
D
E
F
I
G
K
K
A
A
Y
A
L
-
S
E
G
L
G
V
I
A
C
I
G
E
K
L
E
E
R
E
A
G
K
T
F
D
V
C
F
A
Q
L
-----
K
---
A
F
A
D
A
V
-----
P
-----
S
-----
W
-----
D
-----
N
-----
I
---
V
-----
V
A
Y
E
P
V
W
A
I
G
T
G
K
--
V
----
A
S
P
Q
Q
A
Q
--
E
V
H
V
A
V
---------
R
G
W
L
K
K
NVS
E
E
V
A
---------
S
---------
K
------
T
---------
R
---------
I
----------
I
--
Y
G
G
S
V
N
G
G
N
S
A
E
L
A
K
E
E
D
I
D
G
F
L
V
G
G
A
S
L
K
G
P
E
F
A
T
I
V
N
S
V
T
S
K
K
22
PsiBlast_CBE
93.47
38%
-102
- C5 -
2BTM
1
TPIS_GEOSE
B:
[4-247]
-----
I
I
A
G
N
W
K
M
N
G
T
---
L
A
E
A
V
Q
F
V
E
D
V
K
GHV
P
P
A
D
-
E
---
V
I
S
---
V
V
C
A
P
--
F
L
F
L
D
-
R
-
L
V
Q
--
A
AD---
G
----
T
D
-
L
K
I
G
A
Q
T
M
H
F
A
D
Q
G
A
Y
T
G
E
V
S
P
V
M
L
K
D
L
G
V
T
Y
V
I
L
G
H
S
E
R
R
---
Q
MFA
E
T
D
E
T
V
N
K
K
V
L
A
A
F
-
T
R
G
L
I
P
I
I
C
C
G
E
S
L
E
E
R
E
A
G
Q
T
N
A
V
V
A
S
Q
V
-----
E
---
K
---
A
L
AGLT-
P
-----
E
-----
Q
V----
K
-----
Q
-----
A
---
V
-----
I
A
Y
E
P
I
W
A
I
G
T
G
K
--
S
----
S
T
P
E
D
A
N
--
S
V
C
G
H
I
---------
R
S
V
---------
V
---------
S
---------
R
------
L
FGPEAAEAI
R
---------
I
----------
Q
--
Y
G
G
S
V
K
P
D
N
I
R
D
F
L
A
Q
Q
Q
I
D
G
A
L
V
G
G
A
S
L
E
P
A
S
F
L
Q
L
V
E
A
G
R
H
--
3
PsiBlast_PDB
93.28
38%
-105
- C5 -
2BTM
1
TPIS_GEOSE
A:
[4-247]
-----
I
I
A
G
N
W
K
M
N
G
T
---
L
A
E
A
V
Q
F
V
E
D
V
K
GHV
P
P
A
D
-
E
---
V
I
S
---
V
V
C
A
P
--
F
L
F
L
D
-
R
-
L
V
Q
--
A
A
D---
G
----
T
D
-
L
K
I
G
A
Q
T
M
H
F
A
D
Q
G
A
Y
T
G
E
V
S
P
V
M
L
K
D
L
G
V
T
Y
V
I
L
G
H
S
E
R
R
---
Q
MFA
E
T
D
E
T
V
N
K
K
V
L
A
A
F
-
T
R
G
L
I
P
I
I
C
C
G
E
S
L
E
E
R
E
A
G
Q
T
N
A
V
V
A
S
Q
V
-----
E
---
K
---
A
L
AGLT-
P
-----
E
-----
Q
V
----
K
-----
Q
-----
A
---
V
-----
I
A
Y
E
P
I
W
A
I
G
T
G
K
--
S
----
S
T
P
E
D
A
N
--
S
V
C
G
H
I
---------
R
S
V
---------
V
---------
S
---------
R
------
L
FG
P
E
A
A
E
A
I
R
---------
I
----------
Q
--
Y
G
G
S
V
K
P
D
N
I
R
D
F
L
A
Q
Q
Q
I
D
G
A
L
V
G
G
A
S
L
E
P
A
S
F
L
Q
L
V
E
A
G
R
H
--
7
PsiBlast_PDB
92.68
37%
-104
- C5 -
1BTM
1
TPIS_GEOSE
A:
[4-247]
-----
I
I
A
G
N
W
K
M
H
K
T
---
L
A
E
A
V
Q
F
V
E
D
V
K
GHV
P
P
A
D
-
E
---
V
I
S
---
V
V
C
A
P
--
F
L
F
L
D
-
R
-
L
V
Q
--
A
A
D---
G
----
T
D
-
L
K
I
G
A
Q
T
M
H
F
A
D
Q
G
A
Y
T
G
E
V
S
P
V
M
L
K
D
L
G
V
T
Y
V
I
L
G
H
S
E
R
R
---
Q
MFA
E
T
D
E
T
V
N
K
K
V
L
A
A
F
-
T
R
G
L
I
P
I
I
C
C
G
E
S
L
E
E
R
E
A
G
Q
T
N
A
V
V
A
S
Q
V
-----
E
---
K
---
A
L
AGLT-
P
-----
E
-----
Q
V
----
K
-----
Q
-----
A
---
V
-----
I
A
Y
E
P
I
W
A
I
G
T
G
K
--
S
----
S
T
P
E
D
A
N
--
S
V
C
G
H
I
---------
R
S
V
---------
V
---------
S
---------
R
------
L
FG
P
E
A
A
E
A
I
R
---------
I
----------
Q
--
Y
G
G
S
V
K
P
D
N
I
R
D
F
L
A
Q
Q
Q
I
D
G
P
L
V
G
G
A
S
L
E
P
A
S
F
L
Q
L
V
E
A
G
R
H
--
62
PsiBlast_CBE
91.84
34%
-114
- C5 -
4Y8F
5
?
A:
[8-249]
-----
I
I
A
G
N
W
K
M
H
Y
T
---
I
D
E
A
V
K
L
V
E
E
L
K
---
P
L
V
K
-
D
---
A
K
C
-
E
V
V
V
C
P
T
--
F
V
C
L
D
-
A
-
V
K
K
--
A
V
E---
G
----
T
N
-
I
K
V
G
A
Q
N
M
H
F
E
E
K
G
A
F
T
G
E
I
A
P
R
M
L
E
A
M
N
I
D
Y
V
I
I
G
H
S
E
R
R
E
YF
N
---
E
T
D
E
T
C
N
K
K
V
K
A
A
F
-
A
H
N
L
T
P
I
L
C
C
G
E
T
L
E
Q
R
E
N
G
T
T
N
D
V
I
K
A
Q
I
-----
T
---
A
---
D
L
EGLT
K
E
-----
Q
-----
A
-----
E
-----
K
-----
V
---
V
-----
I
A
Y
E
P
I
W
A
I
G
T
G
K
--
T
----
A
T
S
D
Q
A
N
--
E
T
I
A
A
I
R
A
M
V
A
E
M
FG
Q
E
V
---------
A
---------
D
---------
K
------
V
---------
R
---------
I
----------
Q
--
Y
G
G
S
V
K
P
N
T
I
A
E
Q
M
A
K
S
D
I
D
G
A
L
V
G
G
A
S
L
V
A
A
D
F
A
Q
I
V
N
Y
-----
24
PsiBlast_CBE
91.68
37%
-101
- C5 -
1BTM
1
TPIS_GEOSE
B:
[4-247]
-----
I
I
A
G
N
W
K
M
H
K
T
---
L
A
E
A
V
Q
F
V
E
D
V
K
GHV
P
P
A
D
-
E
---
V
I
S
---
V
V
C
A
P
--
F
L
F
L
D
-
R
-
L
V
Q
--
A
AD---
G
----
T
D
-
L
K
I
G
A
Q
T
M
H
F
A
D
Q
G
A
Y
T
G
E
V
S
P
V
M
L
K
D
L
G
V
T
Y
V
I
L
G
H
S
E
R
R
---
Q
MFA
E
T
D
E
T
V
N
K
K
V
L
A
A
F
-
T
R
G
L
I
P
I
I
C
C
G
E
S
L
E
E
R
E
A
G
Q
T
N
A
V
V
A
S
Q
V
-----
E
---
K
---
A
L
AGLT-
P
-----
E
-----
Q
V----
K
-----
Q
-----
A
---
V
-----
I
A
Y
E
P
I
W
A
I
G
T
G
K
--
S
----
S
T
P
E
D
A
N
--
S
V
C
G
H
I
---------
R
S
V
---------
V
---------
S
---------
R
------
L
FGPEAAEAI
R
---------
I
----------
Q
--
Y
G
G
S
V
K
P
D
N
I
R
D
F
L
A
Q
Q
Q
I
D
G
P
L
V
G
G
A
S
L
E
P
A
S
F
L
Q
L
V
E
A
G
R
H
--
124
HHSearch
90.58
35%
-99
- C5 -
3TA6
1
TPIS_MYCTU
A:
[3-256]
--
R
K
P
L
I
A
G
N
W
K
M
N
L
N
---
H
Y
E
A
I
A
L
V
Q
K
I
A
---
F
S
L
P
-
D
K
Y
Y
D
R
V
-
D
V
A
V
I
P
P
--
F
T
D
L
R
-
S
-
V
Q
T
--
L
-----
V
D
G
D
K
L
R
-
L
T
Y
G
A
Q
D
L
S
P
H
D
S
G
A
Y
T
G
D
V
S
G
A
F
L
A
K
L
G
C
S
Y
V
V
V
G
H
S
E
R
R
---
T
YHN
E
D
D
A
L
V
A
A
K
A
A
T
A
L
-
K
H
G
L
T
P
I
V
C
I
G
E
H
L
D
V
R
E
A
G
N
H
V
A
H
N
I
E
Q
L
-----
R
---
G
---
S
L
-----
A
-----
G
LL
A
E
Q
I
-----
G
-----
S
-----
V
---
V
-----
I
A
Y
E
P
V
W
A
I
G
T
G
R
--
V
----
A
S
A
A
D
A
Q
--
E
V
C
A
A
I
---------
R
K
E
---------
L
---------
A
S
L
AS
P
R
I
A
D
T
------
V
---------
R
---------
V
----------
L
--
Y
G
G
S
V
N
A
K
N
V
G
D
I
V
A
Q
D
D
V
D
G
G
L
V
G
G
A
S
L
D
G
E
H
F
A
T
L
A
A
I
A
A
G
--
111
HHSearch
89.91
40%
-93
- C5 -
2BTM
1
TPIS_GEOSE
A:
[1-250]
--
R
K
P
I
I
A
G
N
W
K
M
N
G
T
---
L
A
E
A
V
Q
F
V
E
D
V
K
---
G
H
V
P
-
P
A--
D
E
V
-
I
S
V
V
C
A
P
--
F
L
F
L
D
-
R
-
L
V
Q
--
A
-----
A
DG--
T
D
-
L
K
I
G
A
Q
T
M
H
F
A
D
Q
G
A
Y
T
G
E
V
S
P
V
M
L
K
D
L
G
V
T
Y
V
I
L
G
H
S
E
R
R
---
Q
MFA
E
T
D
E
T
V
N
K
K
V
L
A
A
F
-
T
R
G
L
I
P
I
I
C
C
G
E
S
L
E
E
R
E
A
G
Q
T
N
A
V
V
A
S
Q
V
-----
E
---
K
---
A
L
-----
A
-----
G
-----
L
-----
T
P
E
Q
V
K
Q
-----
A
---
V
-----
I
A
Y
E
P
I
W
A
I
G
T
G
K
--
S
----
S
T
P
E
D
A
N
--
S
V
C
G
H
I
---------
R
S
V
---------
V
---------
S
R
L
FG
P
E
A
A
E
A
------
I
---------
R
---------
I
----------
Q
--
Y
G
G
S
V
K
P
D
N
I
R
D
F
L
A
Q
Q
Q
I
D
G
A
L
V
G
G
A
S
L
E
P
A
S
F
L
Q
L
V
E
A
G
R
H
--
85
PsiBlast_CBE
89.28
35%
-95
- C5 -
4GNJ
2
?
A:
[28-267]
-----
I
V
A
A
N
W
K
C
N
G
T
---
T
A
S
I
E
K
L
V
Q
V
L
N
---
E
H
Q
I
-
D
---
H
D
V
-
Q
C
V
V
A
P
S
--
F
V
H
I
P
-
M
V
Q
A
K
--
L
C----
N
----
P
K
-
Y
A
V
S
A
E
N
A
-
I
A
K
S
G
A
F
T
G
E
V
S
M
P
I
L
K
D
L
G
V
S
W
V
I
L
G
H
S
E
R
R
---
T
YYG
E
T
D
G
V
V
A
Q
K
V
A
D
A
Y
-
N
Q
G
F
M
V
I
A
C
I
G
E
T
L
Q
Q
R
E
A
N
Q
T
A
K
V
V
L
S
Q
T
A
A
I
--
A
---
A
---
K
L
-----
P
-----
K
-----
E
-----
A
WS---
Q
-----
I
---
V
-----
L
A
Y
E
P
V
W
A
I
G
T
-
K
--
V
----
A
T
P
E
Q
A
Q
--
E
V
H
A
L
L
---------
R
Q
W
---------
V
---------
S
---------
E
------
K
IG
N
G
V
A
T
K
L
R
---------
I
----------
L
--
Y
G
G
S
V
T
A
G
N
A
K
T
L
Y
M
K
P
D
I
N
G
F
L
V
G
G
A
S
L
K
-
P
E
F
R
D
I
I
D
A
T
R
---
35
PsiBlast_CBE
88.76
38%
-103
- C5 -
3UWZ
1
TPIS_STAAR
A:
[13-258]
-----
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
P
T
L
P
---
D
-
S
K
-
E
---
V
E
S
---
V
I
C
A
P
--
A
I
Q
L
D
-
A
-
L
T
T
--
A
V
K
E
GK
A
----
Q
G
-
L
E
I
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
LF
H
---
E
T
D
E
E
I
N
K
K
A
H
A
I
F
-
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
-----
K
---
K
---
A
V
-----
A
-----
G
-----
L
-----
S
-----
E
D
Q
L
K
S
V
---
V
-----
I
A
Y
E
P
I
W
A
I
G
T
G
K
--
S
S
T
S
E
D
A
N
E
M
C
A
--
F
V
R
Q
T
I
---------
A
D
L
---------
S
---------
S
---------
K
------
E
V
S
E
A
T
----
R
---------
I
----------
Q
--
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
K
---
102
Fugue
88.64
40%
-95
- C5 -
2BTM
1
TPIS_GEOSE
A:
[1-250]
--
R
K
P
I
I
A
G
N
W
K
M
N
G
T
---
L
A
E
A
V
Q
F
V
E
D
V
K
---
G
H
V
P
-
P
---
A
D
E
V
I
S
V
V
C
A
P
--
F
L
F
L
D
-
R
-
L
V
Q
--
A
A
D---
G
----
T
D
-
L
K
I
G
A
Q
T
M
H
F
A
D
Q
G
A
Y
T
G
E
V
S
P
V
M
L
K
D
L
G
V
T
Y
V
I
L
G
H
S
E
R
R
---
Q
MFA
E
T
D
E
T
V
N
K
K
V
L
A
A
F
-
T
R
G
L
I
P
I
I
C
C
G
E
S
L
E
E
R
E
A
G
Q
T
N
A
V
V
A
S
Q
V
-----
E
---
K
---
A
L
-----
A
-----
G
-----
L
-----
T
-----
P
-----
E
---
Q
V
K
Q
A
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
--
S
----
S
T
P
E
D
A
N
--
S
V
C
G
H
I
---------
R
S
V
---------
V
---------
S
---------
R
------
L
FG
P
E
A
A
E
A
I
R
---------
I
----------
Q
--
Y
G
G
S
V
K
P
D
N
I
R
D
F
L
A
Q
Q
Q
I
D
G
A
L
V
G
G
A
S
L
E
P
A
S
F
L
Q
L
V
E
A
G
R
H
--
84
PsiBlast_CBE
88.46
35%
-98
- C5 -
4GNJ
3
?
B:
[28-267]
-----
I
V
A
A
N
W
K
C
N
G
T
---
T
A
S
I
E
K
L
V
Q
V
L
N
---
E
H
Q
I
-
D
---
H
D
V
-
Q
C
V
V
A
P
S
--
F
V
H
I
P
-
M
V
Q
A
K
--
L
C----
N
----
P
K
-
Y
A
V
S
A
E
N
A
-
I
A
K
S
G
A
F
T
G
E
V
S
M
P
I
L
K
D
L
G
V
S
W
V
I
L
G
H
S
E
R
R
---
T
YYG
E
T
D
G
V
V
A
Q
K
V
A
D
A
Y
-
N
Q
G
F
M
V
I
A
C
I
G
E
T
L
Q
Q
R
E
A
N
Q
T
A
K
V
V
L
S
Q
T
A
A
I
--
A
---
A
---
K
L
-----
P
-----
K
-----
E
-----
A
WS---
Q
-----
I
---
V
-----
L
A
Y
E
P
V
W
A
I
G
--
K
--
V
----
A
T
P
E
Q
A
Q
--
E
V
H
A
L
L
---------
R
Q
W
---------
V
---------
S
---------
E
------
K
IG
N
G
V
A
T
K
L
R
---------
I
----------
L
--
Y
G
G
S
V
T
A
G
N
A
K
T
L
Y
M
K
P
D
I
N
G
F
L
V
G
G
A
S
L
K
-
P
E
F
R
D
I
I
D
A
T
R
---
20
PsiBlast_PDB
87.89
35%
-104
- C5 -
2VOM
-
TPIS_HUMAN
A:
[6-236]
----
F
F
V
G
G
N
W
K
M
N
G
R
---
K
Q
S
L
G
E
L
I
G
T
L
N
---
A
A
K
V
-
P
---
A
D
T
-
E
V
V
C
A
P
P
--
T
A
Y
I
D
F
A
-
R
Q
K
--
L
-----
D
----
P
K
-
I
A
V
A
A
Q
N
C
Y
K
V
T
N
G
A
F
T
G
E
I
S
P
G
M
I
K
D
C
G
A
T
W
V
V
L
G
H
S
E
R
R
---
H
VFG
D
S
D
E
L
I
G
Q
K
V
A
H
A
L
-
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
-----
K
V
I
A
D
---
N
V
-----
K
-----
D
-----
W
-----
S
-----
K
-----
V
---
V
-----
L
A
Y
E
P
V
W
A
I
G
T
G
K
--
T
----
A
T
P
Q
Q
A
Q
--
E
V
H
E
K
L
---------
R
G
W
L
K
S
NVS
D
A
V
A
---------
Q
---------
S
------
T
---------
R
---------
I
----------
I
--
Y
G
G
S
V
T
G
A
T
C
K
E
L
A
S
Q
P
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
A
K
Q
----
40
PsiBlast_CBE
87.80
38%
-101
- C5 -
3UWU
1
TPIS_STAAR
B:
[13-258]
-----
I
I
A
G
N
W
K
M
N
K
T
VQE
A
K
D
F
V
N
A
L
P
T
L
P
---
D
-
S
K
-
E
---
V
E
S
---
V
I
C
A
P
--
A
I
Q
L
D
-
A
-
L
T
T
--
A
VKEGK
A
----
Q
G
-
L
E
I
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
ELF
H
---
E
T
D
E
E
I
N
K
K
A
H
A
I
F
-
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
-----
K
---
K
---
A
V
-----
A
-----
G
-----
L
-----
S
-----
E
DQLKS
V
---
V
-----
I
A
Y
E
P
I
W
A
I
G
T
G
K
--
S
STSE
D
A
N
E
M
C
A
--
F
V
R
Q
T
I
---------
A
D
L
---------
S
---------
S
---------
K
------
E
VSEAT----
R
---------
I
----------
Q
--
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
----
113
HHSearch
87.64
35%
-99
- C5 -
1YYA
7
TPIS_THET8
A:
[2-249]
--
R
R
V
L
V
A
G
N
W
K
M
H
K
T
---
P
S
E
A
R
V
W
F
A
E
L
K
---
R
L
L
P
-
P
---
L
Q
S
-
E
A
A
V
L
P
A
--
F
P
I
L
P
-
V
-
A
K
E
--
V
-----
L
AE--
T
Q
-
V
G
Y
G
A
Q
D
V
S
A
H
K
E
G
A
Y
T
G
E
V
S
A
R
M
L
S
D
L
G
C
R
Y
A
I
V
G
H
S
E
R
R
---
R
YHG
E
T
D
A
L
V
A
E
K
A
K
R
L
L
-
E
E
G
I
T
P
I
L
C
V
G
E
P
L
E
V
R
E
K
G
E
A
V
P
Y
T
L
R
Q
L
-----
R
---
G
---
S
L
-----
E
-----
G
-----
V
EPPGP
E
-----
A
-----
L
---
V
-----
I
A
Y
E
P
V
W
A
I
G
T
G
K
--
N
----
A
T
P
E
D
A
E
--
A
M
H
Q
A
I
---------
R
K
A
---------
L
S
E
R
YG
E
A
F
A
S
---------
R
------
V
---------
R
---------
I
----------
L
--
Y
G
G
S
V
N
P
K
N
F
A
D
L
L
S
M
P
N
V
D
G
G
L
V
G
G
A
S
L
E
L
E
S
F
L
A
L
L
R
I
A
G
---
38
PsiBlast_CBE
87.35
38%
-100
- C5 -
3UWV
4
TPIS_STAAR
B:
[13-258]
-----
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
P
T
L
P
---
D
-
S
K
-
E
---
V
E
S
---
V
I
C
A
P
--
A
I
Q
L
D
-
A
-
L
T
T
--
A
V
K
E
GK
A
----
Q
G
-
L
E
I
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
LF
H
---
E
T
D
E
E
I
N
K
K
A
H
A
I
F
-
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
-----
K
---
K
---
A
V
-----
A
-----
G
-----
L
-----
S
-----
E
D
Q
L
K
S
V
---
V
-----
I
A
Y
E
P
I
W
A
I
G
T
G
K
--
S
S
T
S
E
D
A
N
E
M
C
A
--
F
V
R
Q
T
I
---------
A
D
L
---------
S
---------
S
---------
K
------
E
V
S
E
A
T
----
R
---------
I
----------
Q
--
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
K
---
21
PsiBlast_CBE
87.21
36%
-96
- C5 -
1MO0
3
TPIS_CAEEL
B:
[25-263]
----
F
F
V
G
G
N
W
K
M
N
G
D
---
Y
A
S
V
D
G
I
V
T
F
L
N
---
A
S
A
D
-
N
---
S
S
V
-
D
V
V
V
A
P
P
--
A
P
Y
L
A
Y
A
-
K
S
K
--
L
-----
K
----
A
G
-
V
L
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
L
G
L
E
W
V
I
L
G
H
S
E
R
R
---
H
VFG
E
S
D
A
L
I
A
E
K
T
V
H
A
L
-
E
A
G
I
K
V
V
F
C
I
G
E
K
L
E
E
R
E
A
G
H
T
K
D
V
N
F
R
Q
L
-----
Q
---
A
---
I
V
-----
D
-----
K
-----
G
-----
V
-----
S
-----
W
EN
I
V
-----
I
A
Y
E
P
V
W
A
I
G
T
G
K
--
T
----
A
S
G
E
Q
A
Q
--
E
V
H
E
W
I
---------
R
A
F
---------
L
---------
K
---------
E
------
K
VS
P
A
V
A
D
A
T
R
---------
I
----------
I
--
Y
G
G
S
V
T
A
D
N
A
A
E
L
G
K
K
P
D
I
D
G
F
L
V
G
G
A
S
L
K
P
D
-
F
V
K
I
I
N
A
R
S
---
39
PsiBlast_CBE
87.14
38%
-99
- C5 -
3UWV
5
TPIS_STAAR
A:
[13-258]
-----
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
P
T
L
P
---
D
-
S
K
-
E
---
V
E
S
---
V
I
C
A
P
--
A
I
Q
L
D
-
A
-
L
T
T
--
A
V
K
E
GK
A
----
Q
G
-
L
E
I
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
LF
H
---
E
T
D
E
E
I
N
K
K
A
H
A
I
F
-
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
-----
K
---
K
---
A
V
-----
A
-----
G
-----
L
-----
S
-----
E
D
Q
L
K
S
V
---
V
-----
I
A
Y
E
P
I
W
A
I
G
T
G
K
--
S
S
T
S
E
D
A
N
E
M
C
A
--
F
V
R
Q
T
I
---------
A
D
L
---------
S
---------
S
---------
K
------
E
V
S
E
A
T
----
R
---------
I
----------
Q
--
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
K
---
49
PsiBlast_CBE
87.04
35%
-95
- C5 -
4IOT
1
TPIS_ECODH
A:
[5-252]
-----
L
V
M
G
N
W
K
L
N
G
S
---
R
H
M
V
H
E
L
V
S
N
L
R
---
K
E
L
A
-
G
---
V
A
G
C
A
V
A
I
A
P
P
EM
Y
I
D
M
A
-
K
-
R
E
A
--
E
-----
G
----
S
H
-
I
M
L
G
A
Q
N
V
D
L
N
L
S
G
A
F
T
G
E
T
S
A
A
M
L
K
D
I
G
A
Q
Y
I
I
I
G
H
S
E
R
R
T
Y
-
H
---
K
E
S
D
E
L
I
A
K
K
F
A
V
L
K
E
Q
G
L
T
P
V
L
C
I
G
E
T
E
A
E
N
E
A
G
K
T
E
E
V
C
A
R
Q
I
-----
D
---
A
---
V
L
-----
K
-----
T
-----
Q
-----
G
-----
A
-----
A
---
A
FEG
A
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
--
S
----
A
T
P
A
Q
A
Q
--
A
V
H
K
F
I
---------
R
D
H
---------
I
---------
A
---------
K
V
D
A
N
I
A
E
---------
Q
---------
V
----------
I
I
Q
Y
G
G
S
V
N
A
S
N
A
A
E
L
F
A
Q
P
D
I
D
G
A
L
V
G
G
A
S
L
K
A
D
A
F
A
V
I
V
K
A
A
E
A
A
K
45
PsiBlast_CBE
86.94
38%
-100
- C5 -
3M9Y
3
TPIS_STAAR
B:
[6-251]
-----
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
P
T
L
P
---
D
-
S
K
-
E
---
V
E
S
---
V
I
C
A
P
--
A
I
Q
L
D
-
A
-
L
T
T
--
A
V
K
E
GK
A
----
Q
G
-
L
E
I
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
LF
H
---
E
T
D
E
E
I
N
K
K
A
H
A
I
F
-
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
-----
K
---
K
---
A
V
-----
A
-----
G
-----
L
-----
S
-----
E
D
Q
L
K
S
V
---
V
-----
I
A
Y
E
P
I
W
A
I
G
T
G
K
--
S
S
T
S
E
D
A
N
E
M
C
A
--
F
V
R
Q
T
I
---------
A
D
L
---------
S
---------
S
---------
K
------
E
V
S
E
A
T
----
R
---------
I
----------
Q
--
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
K
---
37
PsiBlast_CBE
86.83
38%
-103
- C5 -
3UWW
3
TPIS_STAAR
A:
[13-258]
-----
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
P
T
L
P
---
D
-
S
K
-
E
---
V
E
S
---
V
I
C
A
P
--
A
I
Q
L
D
-
A
-
L
T
T
--
A
V
K
E
GK
A
----
Q
G
-
L
E
I
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
LF
H
---
E
T
D
E
E
I
N
K
K
A
H
A
I
F
-
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
-----
K
---
K
---
A
V
-----
A
-----
G
-----
L
-----
S
-----
E
D
Q
L
K
S
V
---
V
-----
I
A
Y
E
P
I
W
A
I
G
T
G
K
--
S
S
T
S
E
D
A
N
E
M
C
A
--
F
V
R
Q
T
I
---------
A
D
L
---------
S
---------
S
---------
K
------
E
V
S
E
A
T
----
R
---------
I
----------
Q
--
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
K
---
41
PsiBlast_CBE
86.61
38%
-102
- C5 -
3UWU
2
TPIS_STAAR
A:
[13-258]
-----
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
P
T
L
P
---
D
-
S
K
-
E
---
V
E
S
---
V
I
C
A
P
--
A
I
Q
L
D
-
A
-
L
T
T
--
A
V
K
E
GK
A
----
Q
G
-
L
E
I
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
---
E
T
D
E
E
I
N
K
K
A
H
A
I
F
-
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
-----
K
---
K
---
A
V
-----
A
-----
G
-----
L
-----
S
-----
E
D
Q
L
K
S
V
---
V
-----
I
A
Y
E
P
I
W
A
I
G
T
G
K
--
S
ST
S
E
D
A
N
E
M
C
A
--
F
V
R
Q
T
I
---------
A
D
L
---------
S
---------
S
---------
K
------
E
V
S
E
A
T
----
R
---------
I
----------
Q
--
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
K
---
43
PsiBlast_CBE
86.34
35%
-95
- C5 -
4MVA
4
?
A:
[29-276]
-----
L
V
M
G
N
W
K
L
N
G
S
---
R
H
M
V
H
E
L
V
S
N
L
R
---
K
E
L
A
-
G
---
V
A
G
C
A
V
A
I
A
P
P
EM
Y
I
D
M
A
-
K
-
R
E
A
--
E
-----
G
----
S
H
-
I
M
L
G
A
Q
N
V
D
L
N
L
S
G
A
F
T
G
E
T
S
A
A
M
L
K
D
I
G
A
Q
Y
I
I
I
G
H
S
E
R
R
T
Y
-
H
---
K
E
S
D
E
L
I
A
K
K
F
A
V
L
K
E
Q
G
L
T
P
V
L
C
I
G
E
T
E
A
E
N
E
A
G
K
T
E
E
V
C
A
R
Q
I
-----
D
---
A
---
V
L
-----
K
-----
T
-----
Q
-----
G
-----
A
-----
A
---
A
FEG
A
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
--
S
----
A
T
P
A
Q
A
Q
--
A
V
H
K
F
I
---------
R
D
H
---------
I
---------
A
---------
K
V
D
A
N
I
A
E
---------
Q
---------
V
----------
I
I
Q
Y
G
G
S
V
N
A
S
N
A
A
E
L
F
A
Q
P
D
I
D
G
A
L
V
G
G
A
S
L
K
A
D
A
F
A
V
I
V
K
A
A
E
A
A
K
36
PsiBlast_CBE
86.11
38%
-101
- C5 -
3UWW
3
TPIS_STAAR
B:
[13-258]
-----
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
P
T
L
P
---
D
-
S
K
-
E
---
V
E
S
---
V
I
C
A
P
--
A
I
Q
L
D
-
A
-
L
T
T
--
A
V
K
E
GK
A
----
Q
G
-
L
E
I
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
LF
H
---
E
T
D
E
E
I
N
K
K
A
H
A
I
F
-
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
-----
K
---
K
---
A
V
-----
A
-----
G
-----
L
-----
S
-----
E
D
Q
L
K
S
V
---
V
-----
I
A
Y
E
P
I
W
A
I
G
T
G
K
--
S
ST
S
E
D
A
N
E
M
C
A
--
F
V
R
Q
T
I
---------
A
D
L
---------
S
---------
S
---------
K
------
E
V
S
E
A
T
----
R
---------
I
----------
Q
--
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
----
83
PsiBlast_CBE
85.89
35%
-102
- C5 -
4MKN
6
?
A:
[21-260]
----
F
F
V
G
G
N
W
K
C
N
G
S
---
V
A
N
V
A
K
L
V
D
E
L
N
---
A
G
T
I
-
P
---
R
G
V
-
D
V
V
V
A
P
P
--
F
I
Y
I
D
-
Y
-
V
M
Q
H
-
L
-----
D
----
R
D
K
Y
Q
L
S
A
Q
N
A
W
I
G
G
N
G
A
F
T
G
E
V
S
A
E
Q
L
T
D
F
G
V
P
W
V
I
L
G
H
S
E
R
R
---
S
L
FG
E
S
N
E
V
V
A
K
K
T
S
H
A
L
-
A
A
G
L
G
V
I
A
C
I
G
E
T
L
E
Q
R
N
S
G
S
V
F
K
V
L
D
A
Q
M
-----
D
---
A
---
L
V
-----
D
-----
E
-----
V
-----
K
-----
D
-----
W
---
T
K
V
V
--
L
A
Y
E
P
V
W
A
I
G
T
G
V
--
V
----
A
S
P
E
Q
A
Q
--
E
V
H
A
Y
L
---------
R
Q
Y
---------
C
---------
A
---------
K
------
K
LG
A
A
V
A
D
K
L
R
---------
I
----------
I
--
Y
G
G
S
V
S
D
T
N
C
K
D
L
S
K
Q
E
D
I
D
G
F
L
V
G
G
A
S
L
K
G
A
A
F
V
T
I
C
N
A
A
G
P
K
A
48
PsiBlast_CBE
85.24
36%
-100
- C5 -
4HHP
2
?
A:
[8-239]
-----
I
A
A
A
N
W
K
C
N
G
S
---
E
S
L
L
V
P
L
I
E
T
L
N
---
A
A
T
F
-
D
---
H
D
V
-
Q
C
V
V
A
P
T
--
F
L
H
I
P
-
M
-
T
K
A
R
L
T
-----
N
----
P
K
-
F
Q
I
A
A
Q
N
A
-
I
T
R
S
G
A
F
T
G
E
V
S
L
Q
I
L
K
D
Y
G
I
S
W
V
V
L
G
H
S
E
R
R
L
YY
G
---
D
T
N
E
I
V
A
E
K
V
A
Q
A
C
-
A
A
G
F
H
V
I
V
C
V
G
E
T
N
E
E
R
E
A
G
R
T
A
A
V
V
L
T
Q
L
A
A
V
A
Q
K
---
L
---
S
K
-----
E
-----
A
-----
W
-----
S
-----
R
-----
V
---
V
-----
I
A
Y
E
P
V
W
A
I
G
T
G
K
--
V
----
A
T
P
Q
Q
A
Q
--
E
V
H
E
L
L
---------
R
R
W
---------
V
---------
R
---------
S
------
K
LG
T
D
I
A
A
Q
L
R
---------
I
----------
L
--
Y
G
G
S
V
T
A
K
N
A
R
T
L
Y
Q
M
R
D
I
N
G
F
L
V
G
G
A
S
L
K
P
E
F
V
E
I
I
E
A
T
K
----
55
PsiBlast_CBE
84.79
35%
-94
- C5 -
4OWG
1
TPIS_RABIT
A:
[6-236]
----
F
F
V
G
G
N
W
K
M
N
G
R
---
K
K
N
L
G
E
L
I
T
T
L
N
---
A
A
K
V
-
P
---
A
D
T
-
E
V
V
C
A
P
P
--
T
A
Y
I
D
F
A
-
R
Q
K
--
L
-----
D
----
P
K
-
I
A
V
A
A
Q
N
C
Y
K
V
T
N
G
A
F
T
G
E
I
S
P
G
M
I
K
D
C
G
A
T
W
V
V
L
G
H
S
E
R
R
---
H
V
FG
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
-
S
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
-----
K
V
I
A
D
---
N
V
-----
K
-----
D
-----
W
-----
S
-----
K
-----
V
---
V
-----
L
A
Y
E
P
V
W
A
I
G
T
G
K
--
T
----
A
T
P
Q
Q
A
Q
--
E
V
H
E
K
L
---------
R
G
W
L
K
S
N
VS
D
A
V
A
---------
Q
---------
S
------
T
---------
R
---------
I
----------
I
--
Y
G
G
S
V
T
G
A
T
C
K
E
L
A
S
Q
P
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
A
K
Q
----
34
PsiBlast_CBE
84.51
38%
-102
- C5 -
3UWZ
2
TPIS_STAAR
B:
[13-258]
-----
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
P
T
L
P
---
D
-
S
K
-
E
---
V
E
S
---
V
I
C
A
P
--
A
I
Q
L
D
-
A
-
L
T
T
--
A
V
K
E
GK
A
----
Q
G
-
L
E
I
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
LF
H
---
E
T
D
E
E
I
N
K
K
A
H
A
I
F
-
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
-----
K
---
K
---
A
V
-----
A
-----
G
-----
L
-----
S
-----
E
D
Q
L
K
S
V
---
V
-----
I
A
Y
E
P
I
W
A
I
---
K
--
S
ST
S
E
D
A
N
E
M
C
A
--
F
V
R
Q
T
I
---------
A
D
L
---------
S
---------
S
---------
K
------
E
V
S
E
A
T
----
R
---------
I
----------
Q
--
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
K
---
28
PsiBlast_CBE
84.51
35%
-92
- C5 -
1HTI
1
TPIS_HUMAN
B:
[6-236]
----
F
F
V
G
G
N
W
K
M
N
G
R
---
K
Q
S
L
G
E
L
I
G
T
L
N
---
A
A
K
V
-
P
---
A
D
T
-
E
V
V
C
A
P
P
--
T
A
Y
I
D
F
A
-
R
Q
K
--
L
-----
D
----
P
K
-
I
A
V
A
A
Q
N
C
Y
K
V
T
N
G
A
F
T
G
E
I
S
P
G
M
I
K
D
C
G
A
T
W
V
V
L
G
H
S
E
R
R
---
H
VFG
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
-
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
-----
K
VIA
D
---
N
V
-----
K
-----
D
-----
W
-----
S
-----
K
-----
V
---
V
-----
L
A
Y
E
P
V
W
A
I
G
T
G
K
--
T
----
A
T
P
Q
Q
A
Q
--
E
V
H
E
K
L
---------
R
G
W
LKSNVSDAV
A
---------
Q
---------
S
------
T
---------
R
---------
I
----------
I
--
Y
G
G
S
V
T
G
A
T
C
K
E
L
A
S
Q
P
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
A
K
Q
----
54
PsiBlast_CBE
84.12
35%
-94
- C5 -
4OWG
1
TPIS_RABIT
B:
[6-236]
----
F
F
V
G
G
N
W
K
M
N
G
R
---
K
K
N
L
G
E
L
I
T
T
L
N
---
A
A
K
V
-
P
---
A
D
T
-
E
V
V
C
A
P
P
--
T
A
Y
I
D
F
A
-
R
Q
K
--
L
-----
D
----
P
K
-
I
A
V
A
A
Q
N
C
Y
K
V
T
N
G
A
F
T
G
E
I
S
P
G
M
I
K
D
C
G
A
T
W
V
V
L
G
H
S
E
R
R
---
H
VFG
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
-
S
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
-----
K
VIA
D
---
N
V
-----
K
-----
D
-----
W
-----
S
-----
K
-----
V
---
V
-----
L
A
Y
E
P
V
W
A
I
G
T
G
K
--
T
----
A
T
P
Q
Q
A
Q
--
E
V
H
E
K
L
---------
R
G
W
LKSNVSDAV
A
---------
Q
---------
S
------
T
---------
R
---------
I
----------
I
--
Y
G
G
S
V
T
G
A
T
C
K
E
L
A
S
Q
P
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
A
K
-----
42
PsiBlast_CBE
83.80
35%
-93
- C5 -
4MVA
3
?
B:
[29-276]
-----
L
V
M
G
N
W
K
L
N
G
S
---
R
H
M
V
H
E
L
V
S
N
L
R
---
K
E
L
A
-
G
---
V
A
G
C
A
V
A
I
A
P
P
EM
Y
I
D
M
A
-
K
-
R
E
A
--
E
-----
G
----
S
H
-
I
M
L
G
A
Q
N
V
D
L
N
L
S
G
A
F
T
G
E
T
S
A
A
M
L
K
D
I
G
A
Q
Y
I
I
I
G
H
S
E
R
R
TY-
H
---
K
E
S
D
E
L
I
A
K
K
F
A
V
L
K
E
Q
G
L
T
P
V
L
C
I
G
E
T
E
A
E
N
E
A
G
K
T
E
E
V
C
A
R
Q
I
-----
D
---
A
---
V
L
-----
K
-----
T
-----
Q
-----
G
-----
A
-----
A
---
A
FEGAV
I
A
Y
E
P
V
W
A
I
G
T
G
K
--
S
----
A
T
P
A
Q
A
Q
--
A
V
H
K
F
I
---------
R
D
H
---------
I
---------
A
---------
K
VDANIA
E
---------
Q
---------
V
----------
I
IQ
Y
G
G
S
V
N
A
S
N
A
A
E
L
F
A
Q
P
D
I
D
G
A
L
V
G
G
A
S
L
K
A
D
A
F
A
V
I
V
K
A
A
E
A
A
K
116
HHSearch
83.79
36%
-92
- C5 -
2J27
1
TPIS_TRYBB
A:
[4-250]
--
P
Q
P
I
A
A
A
N
W
K
C
N
G
S
---
Q
Q
S
L
S
E
L
I
D
L
F
N
---
S
T
S
I
-
N
---
H
D
V
-
Q
C
V
V
A
S
T
--
F
V
H
L
A
-
M
-
T
K
E
--
R
-----
L
SH--
P
K
-
F
V
I
A
A
Q
N
A
I
-
A
K
S
G
A
F
T
G
E
V
S
L
P
I
L
K
D
F
G
V
N
W
I
V
L
G
H
S
E
R
R
---
A
YYG
E
T
N
E
I
V
A
D
K
V
A
A
A
V
-
A
S
G
F
M
V
I
A
C
I
G
E
T
L
Q
E
R
E
S
G
R
T
A
V
V
V
L
T
Q
I
-----
A
---
A
---
I
A
-----
K
-----
K
-----
L
KKADW
A
-----
K
-----
V
---
V
-----
I
A
Y
E
A
V
W
A
I
G
T
G
K
--
V
----
A
T
P
Q
Q
A
Q
--
E
A
H
A
L
I
---------
R
S
W
---------
V
---------
S
S
K
IG
A
D
V
A
G
E
------
L
---------
R
---------
I
----------
L
--
Y
G
G
S
V
N
G
K
N
A
R
T
L
Y
Q
Q
R
D
V
N
G
F
L
V
G
G
A
S
L
K
P
E
-
F
V
D
I
I
K
A
T
Q
---
68
PsiBlast_CBE
83.68
36%
-98
- C5 -
1SSG
4
TPIS_CHICK
A:
[5-235]
----
F
F
V
G
G
N
W
K
M
N
G
D
---
K
K
S
L
G
E
L
I
H
T
L
N
---
G
A
K
L
-
S
---
A
D
T
-
E
V
V
C
G
A
P
--
S
I
Y
L
D
F
A
-
R
Q
K
--
L
-----
D
----
A
K
-
I
G
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
I
G
A
A
W
V
I
L
G
H
S
E
R
R
---
H
VFG
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
-
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
-----
K
---
A
I
A
D
N
V
-----
K
-----
D
-----
W
-----
S
-----
K
-----
V
---
V
-----
L
A
Y
E
P
V
W
A
I
G
T
G
Y
--
S
----
L
T
P
Q
Q
A
Q
--
E
V
H
E
K
L
---------
R
G
W
---------
L
-------------------
K
------
S
---------
H
---------
V
S
D
A
V
A
Q
S
T
R
I
I
--
Y
G
G
S
V
T
G
G
N
C
K
E
L
A
S
Q
H
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
A
K
H
----
80
PsiBlast_CBE
82.98
36%
-95
- C5 -
1TPW
1
TPIS_CHICK
A:
[5-235]
----
F
F
V
G
G
N
W
K
M
N
G
D
---
K
K
S
L
G
E
L
I
H
T
L
N
---
G
A
K
L
-
S
---
A
D
T
-
E
V
V
C
G
A
P
--
S
I
Y
L
D
F
A
-
R
Q
K
--
L
-----
D
----
A
K
-
I
G
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
I
G
A
A
W
V
I
L
G
H
P
E
R
R
---
H
VFG
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
-
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
-----
K
---
A
I
A
D
N
V
-----
K
-----
D
-----
W
-----
S
-----
K
-----
V
---
V
-----
L
A
Y
E
P
V
W
A
I
G
T
G
K
--
T
----
A
T
P
Q
Q
A
Q
--
E
V
H
E
K
L
---------
R
G
W
---------
L
-------------------
K
------
T
---------
H
---------
V
S
D
A
V
A
Q
S
T
R
I
I
--
Y
G
G
S
V
T
G
G
N
C
K
E
L
A
S
Q
H
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
A
K
H
----
79
PsiBlast_CBE
82.61
36%
-99
- C5 -
1TPW
1
TPIS_CHICK
B:
[5-235]
----
F
F
V
G
G
N
W
K
M
N
G
D
---
K
K
S
L
G
E
L
I
H
T
L
N
---
G
A
K
L
-
S
---
A
D
T
-
E
V
V
C
G
A
P
--
S
I
Y
L
D
F
A
-
R
Q
K
--
L
-----
D
----
A
K
-
I
G
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
I
G
A
A
W
V
I
L
G
H
P
E
R
R
---
H
VFG
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
-
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
-----
K
---
A
IAD
N
V
-----
K
-----
D
-----
W
-----
S
-----
K
-----
V
---
V
-----
L
A
Y
E
P
V
W
A
I
G
T
G
K
--
T
----
A
T
P
Q
Q
A
Q
--
E
V
H
E
K
L
---------
R
G
W
---------
L
-------------------
K
------
T
---------
H
---------
V
SDAVAQSTRI
I
--
Y
G
G
S
V
T
G
G
N
C
K
E
L
A
S
Q
H
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
A
K
H
----
101
Fugue
82.56
35%
-89
- C5 -
1IF2
1
TPIS_LEIME
A:
[3-251]
AK
P
Q
P
I
A
A
A
N
W
K
C
N
G
T
---
T
A
S
I
E
K
L
V
Q
V
F
N
---
E
H
T
I
-
S
---
H
D
V
-
Q
C
V
V
A
P
T
--
F
V
H
I
P
-
L
-
V
Q
A
--
K
LR---
N
----
P
K
-
Y
V
I
S
A
Q
N
A
I
-
A
K
S
G
A
F
T
G
E
V
S
M
P
I
L
K
D
I
G
V
H
W
V
I
L
G
H
S
E
R
R
---
T
YYG
E
T
D
E
I
V
A
Q
K
V
S
E
A
C
-
K
Q
G
F
M
V
I
A
C
I
G
E
T
L
Q
Q
R
E
A
N
Q
T
A
K
V
V
L
S
Q
T
-----
S
---
A
---
I
A
-----
A
K
LTKD
A
-----
W
-----
N
-----
Q
-----
V
---
V
-----
L
A
Y
E
P
V
W
A
I
G
T
G
K
--
V
----
A
T
P
E
Q
A
Q
--
E
V
H
L
L
L
---------
R
K
W
---------
V
---------
S
---------
E
------
N
---------
I
G
T
D
V
A
A
K
L
R
I
----------
L
--
Y
G
G
S
V
N
A
A
N
A
A
T
L
Y
A
K
P
D
I
N
G
F
L
V
G
G
A
S
L
K
-
P
E
F
R
D
I
I
D
A
T
R
---
52
PsiBlast_CBE
82.48
37%
-96
- C5 -
1SW3
1
TPIS_CHICK
B:
[6-236]
----
F
F
V
G
G
N
W
K
M
N
G
D
---
K
K
S
L
G
E
L
I
H
T
L
N
---
G
A
K
L
-
S
---
A
D
T
-
E
V
V
C
G
A
P
--
S
I
Y
L
D
F
A
-
R
Q
K
--
L
-----
D
----
A
K
-
I
G
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
I
G
A
A
W
V
I
L
G
H
S
E
R
R
---
H
VFG
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
-
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
-----
K
---
A
IAD
N
V
-----
K
-----
D
-----
W
-----
S
-----
K
-----
V
---
V
-----
L
A
Y
E
P
V
W
A
I
G
T
G
K
--
V
----
A
T
P
Q
Q
A
Q
--
E
V
H
E
K
L
---------
R
G
W
---------
L
-------------------
K
------
S
---------
H
---------
V
SDAVAQSTRI
I
--
Y
G
G
S
V
T
G
G
N
C
K
E
L
A
S
Q
H
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
A
K
H
----
53
PsiBlast_CBE
82.36
37%
-98
- C5 -
1SW3
1
TPIS_CHICK
A:
[6-236]
----
F
F
V
G
G
N
W
K
M
N
G
D
---
K
K
S
L
G
E
L
I
H
T
L
N
---
G
A
K
L
-
S
---
A
D
T
-
E
V
V
C
G
A
P
--
S
I
Y
L
D
F
A
-
R
Q
K
--
L
-----
D
----
A
K
-
I
G
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
I
G
A
A
W
V
I
L
G
H
S
E
R
R
---
H
VFG
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
-
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
-----
K
---
A
I
A
D
N
V
-----
K
-----
D
-----
W
-----
S
-----
K
-----
V
---
V
-----
L
A
Y
E
P
V
W
A
I
G
T
G
K
--
V
----
A
T
P
Q
Q
A
Q
--
E
V
H
E
K
L
---------
R
G
W
---------
L
-------------------
K
------
S
---------
H
---------
V
S
D
A
V
A
Q
S
T
R
I
I
--
Y
G
G
S
V
T
G
G
N
C
K
E
L
A
S
Q
H
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
A
K
H
----
118
HHSearch
82.28
34%
-93
- C5 -
1O5X
2
TPIS_PLAFA
A:
[3-247]
--
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
---
L
E
S
I
K
S
L
T
N
S
F
N
---
N
L
D
F
D
P
---
S
K
L
-
D
V
V
V
F
P
V
--
S
V
H
Y
D
-
H
-
T
R
K
--
L
-----
L
Q---
S
K
-
F
S
T
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
---
K
YFH
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
-
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
-----
K
---
A
---
F
V
-----
D
-----
L
IDN--
F
-----
D
-----
N
-----
V
---
I
-----
L
V
Y
E
P
L
W
A
I
G
T
G
K
--
T
----
A
T
P
E
Q
A
Q
--
L
V
H
K
E
I
---------
R
K
I
---------
V
---------
K
D
T
CG
E
K
Q
A
N
Q
------
I
---------
R
---------
I
----------
L
--
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
E
-
S
F
V
D
I
I
K
S
A
M
---
122
HHSearch
82.26
35%
-87
- C5 -
2VXN
7
TPIS_LEIME
A:
[5-250]
--
P
Q
P
I
A
A
A
N
W
K
C
N
G
T
---
T
A
S
I
E
K
L
V
Q
V
F
N
---
E
H
T
I
-
S
---
H
D
V
-
Q
C
V
V
A
P
T
--
F
V
H
I
P
-
L
-
V
Q
A
--
K
-----
L
RN--
P
K
-
Y
V
I
S
A
Q
N
A
I
-
A
K
S
G
A
F
T
G
E
V
S
M
P
I
L
K
D
I
G
V
H
W
V
I
L
G
H
S
E
R
R
---
T
YYG
E
T
D
E
I
V
A
Q
K
V
S
E
A
C
-
K
Q
G
F
M
V
I
A
C
I
G
E
T
L
Q
Q
R
E
A
N
Q
T
A
K
V
V
L
S
Q
T
-----
S
---
A
---
I
A
-----
A
-----
K
-----
L
TKDAW
N
-----
Q
-----
V
---
V
-----
L
A
Y
E
P
V
W
A
I
G
T
G
K
--
V
----
A
T
P
E
Q
A
Q
--
E
V
H
L
L
L
---------
R
K
W
---------
V
S
E
N
IG
T
D
V
A
A
---------
K
------
L
---------
R
---------
I
----------
L
--
Y
G
G
S
V
N
A
A
N
A
A
T
L
Y
A
K
P
D
I
N
G
F
L
V
G
G
A
S
L
K
P
E
-
F
R
D
I
I
D
A
T
R
---
81
PsiBlast_CBE
82.19
36%
-93
- C5 -
1TPU
1
TPIS_CHICK
B:
[5-235]
----
F
F
V
G
G
N
W
K
M
N
G
D
---
K
K
S
L
G
E
L
I
H
T
L
N
---
G
A
K
L
-
S
---
A
D
T
-
E
V
V
C
G
A
P
--
S
I
Y
L
D
F
A
-
R
Q
K
--
L
-----
D
----
A
K
-
I
G
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
I
G
A
A
W
V
I
L
G
N
S
E
R
R
---
H
VFG
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
-
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
-----
K
---
A
IAD
N
V
-----
K
-----
D
-----
W
-----
S
-----
K
-----
V
---
V
-----
L
A
Y
E
P
V
W
A
I
G
T
G
K
--
T
----
A
T
P
Q
Q
A
Q
--
E
V
H
E
K
L
---------
R
G
W
---------
L
-------------------
K
------
T
---------
H
---------
V
SDAVAQSTRI
I
--
Y
G
G
S
V
T
G
G
N
C
K
E
L
A
S
Q
H
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
A
K
H
----
67
PsiBlast_CBE
81.84
36%
-97
- C5 -
1SSG
6
TPIS_CHICK
B:
[5-235]
----
F
F
V
G
G
N
W
K
M
N
G
D
---
K
K
S
L
G
E
L
I
H
T
L
N
---
G
A
K
L
-
S
---
A
D
T
-
E
V
V
C
G
A
P
--
S
I
Y
L
D
F
A
-
R
Q
K
--
L
-----
D
----
A
K
-
I
G
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
I
G
A
A
W
V
I
L
G
H
S
E
R
R
---
H
VFG
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
-
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
-----
K
---
A
IAD
N
V
-----
K
-----
D
-----
W
-----
S
-----
K
-----
V
---
V
-----
L
A
Y
E
P
V
W
A
I
G
T
G
Y
--
S
----
L
T
P
Q
Q
A
Q
--
E
V
H
E
K
L
---------
R
G
W
---------
L
-------------------
K
------
S
---------
H
---------
V
SDAVAQSTRI
I
--
Y
G
G
S
V
T
G
G
N
C
K
E
L
A
S
Q
H
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
A
K
H
----
82
PsiBlast_CBE
81.78
36%
-95
- C5 -
1TPU
1
TPIS_CHICK
A:
[5-235]
----
F
F
V
G
G
N
W
K
M
N
G
D
---
K
K
S
L
G
E
L
I
H
T
L
N
---
G
A
K
L
-
S
---
A
D
T
-
E
V
V
C
G
A
P
--
S
I
Y
L
D
F
A
-
R
Q
K
--
L
-----
D
----
A
K
-
I
G
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
I
G
A
A
W
V
I
L
G
N
S
E
R
R
---
H
VFG
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
-
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
-----
K
---
A
I
A
D
N
V
-----
K
-----
D
-----
W
-----
S
-----
K
-----
V
---
V
-----
L
A
Y
E
P
V
W
A
I
G
T
G
K
--
T
----
A
T
P
Q
Q
A
Q
--
E
V
H
E
K
L
---------
R
G
W
---------
L
-------------------
K
------
T
---------
H
---------
V
S
D
A
V
A
Q
S
T
R
I
I
--
Y
G
G
S
V
T
G
G
N
C
K
E
L
A
S
Q
H
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
A
K
H
----
65
PsiBlast_CBE
81.41
36%
-95
- C5 -
1SW7
1
TPIS_CHICK
B:
[6-236]
----
F
F
V
G
G
N
W
K
M
N
G
D
---
K
K
S
L
G
E
L
I
H
T
L
N
---
G
A
K
L
-
S
---
A
D
T
-
E
V
V
C
G
A
P
--
S
I
Y
L
D
F
A
-
R
Q
K
--
L
-----
D
----
A
K
-
I
G
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
I
G
A
A
W
V
I
L
G
H
S
E
R
R
---
H
VFG
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
-
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
-----
K
---
A
IAD
N
V
-----
K
-----
D
-----
W
-----
S
-----
K
-----
V
---
V
-----
L
A
Y
E
P
V
W
A
I
G
T
G
N
--
S
----
S
T
P
Q
Q
A
Q
--
E
V
H
E
K
L
---------
R
G
W
---------
L
-------------------
K
------
S
---------
H
---------
V
SDAVAQSTRI
I
--
Y
G
G
S
V
T
G
G
N
C
K
E
L
A
S
Q
H
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
A
K
H
----
72
PsiBlast_CBE
81.10
36%
-98
- C5 -
1SW0
1
TPIS_CHICK
A:
[6-236]
----
F
F
V
G
G
N
W
K
M
N
G
D
---
K
K
S
L
G
E
L
I
H
T
L
N
---
G
A
K
L
-
S
---
A
D
T
-
E
V
V
C
G
A
P
--
S
I
Y
L
D
F
A
-
R
Q
K
--
L
-----
D
----
A
K
-
I
G
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
I
G
A
A
W
V
I
L
G
H
S
E
R
R
---
H
VFG
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
-
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
-----
K
---
A
I
A
D
N
V
-----
K
-----
D
-----
W
-----
S
-----
K
-----
V
---
V
-----
L
A
Y
E
P
V
W
A
I
G
T
G
L
--
W
----
A
T
P
Q
Q
A
Q
--
E
V
H
E
K
L
---------
R
G
W
---------
L
-------------------
K
------
S
---------
H
---------
V
S
D
A
V
A
Q
S
T
R
I
I
--
Y
G
G
S
V
T
G
G
N
C
K
E
L
A
S
Q
H
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
A
K
H
----
66
PsiBlast_CBE
81.06
36%
-99
- C5 -
1SW7
1
TPIS_CHICK
A:
[6-236]
----
F
F
V
G
G
N
W
K
M
N
G
D
---
K
K
S
L
G
E
L
I
H
T
L
N
---
G
A
K
L
-
S
---
A
D
T
-
E
V
V
C
G
A
P
--
S
I
Y
L
D
F
A
-
R
Q
K
--
L
-----
D
----
A
K
-
I
G
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
I
G
A
A
W
V
I
L
G
H
S
E
R
R
---
H
VFG
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
-
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
-----
K
---
A
I
A
D
N
V
-----
K
-----
D
-----
W
-----
S
-----
K
-----
V
---
V
-----
L
A
Y
E
P
V
W
A
I
G
T
G
N
--
S
----
S
T
P
Q
Q
A
Q
--
E
V
H
E
K
L
---------
R
G
W
---------
L
-------------------
K
------
S
---------
H
---------
V
S
D
A
V
A
Q
S
T
R
I
I
--
Y
G
G
S
V
T
G
G
N
C
K
E
L
A
S
Q
H
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
A
K
H
----
78
PsiBlast_CBE
80.80
36%
-95
- C5 -
1SU5
7
TPIS_CHICK
A:
[5-235]
----
F
F
V
G
G
N
W
K
M
N
G
D
---
K
K
S
L
G
E
L
I
H
T
L
N
---
G
A
K
L
-
S
---
A
D
T
-
E
V
V
C
G
A
P
--
S
I
Y
L
D
F
A
-
R
Q
K
--
L
-----
D
----
A
K
-
I
G
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
I
G
A
A
W
V
I
L
G
H
S
E
R
R
---
H
VFG
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
-
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
-----
K
---
A
I
A
D
N
V
-----
K
-----
D
-----
W
-----
S
-----
K
-----
V
---
V
-----
L
A
Y
E
P
V
W
A
I
G
T
G
N
--
P
----
N
T
P
Q
Q
A
Q
--
E
V
H
E
K
L
---------
R
G
W
---------
L
-------------------
K
------
S
---------
H
---------
V
S
D
A
V
A
Q
S
T
R
I
I
--
Y
G
G
S
V
T
G
G
N
C
K
E
L
A
S
Q
H
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
A
K
H
----
89
PsiBlast_CBE
80.69
35%
-93
- C5 -
1TPV
1
TPIS_CHICK
A:
[5-235]
----
F
F
V
G
G
N
W
K
M
N
G
D
---
K
K
S
L
G
E
L
I
H
T
L
N
---
G
A
K
L
-
S
---
A
D
T
-
E
V
V
C
G
A
P
--
S
I
Y
L
D
F
A
-
R
Q
K
--
L
-----
D
----
A
K
-
I
G
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
I
G
A
A
W
V
I
L
G
N
P
E
R
R
---
H
VFG
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
-
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
-----
K
---
A
I
A
D
N
V
-----
K
-----
D
-----
W
-----
S
-----
K
-----
V
---
V
-----
L
A
Y
E
P
V
W
A
I
G
T
G
K
--
T
----
A
T
P
Q
Q
A
Q
--
E
V
H
E
K
L
---------
R
G
W
---------
L
-------------------
K
------
T
---------
H
---------
V
S
D
A
V
A
Q
S
T
R
I
I
--
Y
G
G
S
V
T
G
G
N
C
K
E
L
A
S
Q
H
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
A
K
H
----
50
PsiBlast_CBE
80.57
34%
-100
- C5 -
4FF7
13
TPIS_YEAST
B:
[4-236]
---
T
F
F
V
G
G
N
F
K
L
N
G
S
---
K
Q
S
I
K
E
I
V
E
R
L
N
---
T
A
S
I
-
P
---
E
N
V
-
E
V
V
I
C
P
P
--
A
T
Y
L
D
-
Y
-
S
V
S
--
L
VK---
K
----
P
Q
-
V
T
V
G
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
H
S
E
R
R
SYF
H
---
E
D
D
K
F
I
A
D
K
T
K
F
A
L
-
G
Q
G
V
G
V
I
L
S
I
G
E
T
L
E
E
K
K
A
G
K
T
L
D
V
V
E
R
Q
L
-----
N
---
A
---
V
L
-----
E
-----
E
-----
V
-----
K
-----
D
-----
W
---
T
NVV--
V
A
Y
E
P
V
W
A
I
G
T
G
L
--
A
----
A
T
P
E
D
A
Q
--
D
I
H
A
S
I
---------
R
K
F
---------
L
---------
A
---------
S
------
K
LGDKAASEL
R
---------
I
----------
L
--
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
S
R
N
----
71
PsiBlast_CBE
80.56
36%
-96
- C5 -
1SW0
1
TPIS_CHICK
B:
[6-236]
----
F
F
V
G
G
N
W
K
M
N
G
D
---
K
K
S
L
G
E
L
I
H
T
L
N
---
G
A
K
L
-
S
---
A
D
T
-
E
V
V
C
G
A
P
--
S
I
Y
L
D
F
A
-
R
Q
K
--
L
-----
D
----
A
K
-
I
G
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
I
G
A
A
W
V
I
L
G
H
S
E
R
R
---
H
VFG
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
-
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
-----
K
---
A
IAD
N
V
-----
K
-----
D
-----
W
-----
S
-----
K
-----
V
---
V
-----
L
A
Y
E
P
V
W
A
I
G
T
G
L
--
W
----
A
T
P
Q
Q
A
Q
--
E
V
H
E
K
L
---------
R
G
W
---------
L
-------------------
K
------
S
---------
H
---------
V
SDAVAQSTRI
I
--
Y
G
G
S
V
T
G
G
N
C
K
E
L
A
S
Q
H
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
A
K
H
----
88
PsiBlast_CBE
79.78
35%
-93
- C5 -
1TPV
1
TPIS_CHICK
B:
[5-235]
----
F
F
V
G
G
N
W
K
M
N
G
D
---
K
K
S
L
G
E
L
I
H
T
L
N
---
G
A
K
L
-
S
---
A
D
T
-
E
V
V
C
G
A
P
--
S
I
Y
L
D
F
A
-
R
Q
K
--
L
-----
D
----
A
K
-
I
G
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
I
G
A
A
W
V
I
L
G
N
P
E
R
R
---
H
VFG
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
-
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
-----
K
---
A
IAD
N
V
-----
K
-----
D
-----
W
-----
S
-----
K
-----
V
---
V
-----
L
A
Y
E
P
V
W
A
I
G
T
G
K
--
T
----
A
T
P
Q
Q
A
Q
--
E
V
H
E
K
L
---------
R
G
W
---------
L
-------------------
K
------
T
---------
H
---------
V
SDAVAQSTRI
I
--
Y
G
G
S
V
T
G
G
N
C
K
E
L
A
S
Q
H
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
A
K
H
----
77
PsiBlast_CBE
79.09
36%
-92
- C5 -
1SU5
8
TPIS_CHICK
B:
[5-235]
----
F
F
V
G
G
N
W
K
M
N
G
D
---
K
K
S
L
G
E
L
I
H
T
L
N
---
G
A
K
L
-
S
---
A
D
T
-
E
V
V
C
G
A
P
--
S
I
Y
L
D
F
A
-
R
Q
K
--
L
-----
D
----
A
K
-
I
G
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
I
G
A
A
W
V
I
L
G
H
S
E
R
R
---
H
VFG
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
-
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
-----
K
---
A
IAD
N
V
-----
K
-----
D
-----
W
-----
S
-----
K
-----
V
---
V
-----
L
A
Y
E
P
V
W
A
I
G
T
G
N
--
P
----
N
T
P
Q
Q
A
Q
--
E
V
H
E
K
L
---------
R
G
W
---------
L
-------------------
K
------
S
---------
H
---------
V
SDAVAQSTRI
I
--
Y
G
G
S
V
T
G
G
N
C
K
E
L
A
S
Q
H
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
A
K
H
----
51
PsiBlast_CBE
78.94
34%
-97
- C5 -
4FF7
9
TPIS_YEAST
A:
[4-236]
---
T
F
F
V
G
G
N
F
K
L
N
G
S
---
K
Q
S
I
K
E
I
V
E
R
L
N
---
T
A
S
I
-
P
---
E
N
V
-
E
V
V
I
C
P
P
--
A
T
Y
L
D
-
Y
-
S
V
S
--
L
VK---
K
----
P
Q
-
V
T
V
G
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
H
S
E
R
R
S
YF
H
---
E
D
D
K
F
I
A
D
K
T
K
F
A
L
-
G
Q
G
V
G
V
I
L
S
I
G
E
T
L
E
E
K
K
A
G
K
T
L
D
V
V
E
R
Q
L
-----
N
---
A
---
V
L
-----
E
-----
E
-----
V
-----
K
-----
D
-----
W
---
T
N
V
V
--
V
A
Y
E
P
V
W
A
I
G
T
G
L
--
A
----
A
T
P
E
D
A
Q
--
D
I
H
A
S
I
---------
R
K
F
---------
L
---------
A
---------
S
------
K
LG
D
K
A
A
S
E
L
R
---------
I
----------
L
--
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
S
R
N
----
27
PsiBlast_CBE
77.84
34%
-94
- C5 -
2YPI
1
TPIS_YEAST
B:
[3-235]
---
T
F
F
V
G
G
N
F
K
L
N
G
S
---
K
Q
S
I
K
E
I
V
E
R
L
N
---
T
A
S
I
-
P
---
E
N
V
-
E
V
V
I
C
P
P
--
A
T
Y
L
D
-
Y
-
S
V
S
--
L
VK---
K
----
P
Q
-
V
T
V
G
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
H
S
E
R
R
SYF
H
---
E
D
D
K
F
I
A
D
K
T
K
F
A
L
-
G
Q
G
V
G
V
I
L
C
I
G
E
T
L
E
E
K
K
A
G
K
T
L
D
V
V
E
R
Q
L
-----
N
---
A
---
V
L
-----
E
-----
E
-----
V
-----
K
-----
D
-----
W
---
T
NVV--
V
A
Y
E
P
V
W
A
I
G
T
G
L
--
A
----
A
T
P
E
D
A
Q
--
D
I
H
A
S
I
---------
R
K
F
---------
L
---------
A
---------
S
------
K
LGDKAASEL
R
---------
I
----------
L
--
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
S
R
N
----
11
PsiBlast_PDB
76.72
34%
-94
- C5 -
7TIM
1
TPIS_YEAST
A:
[3-235]
---
T
F
F
V
G
G
N
F
K
L
N
G
S
---
K
Q
S
I
K
E
I
V
E
R
L
N
---
T
A
S
I
-
P
---
E
N
V
-
E
V
V
I
C
P
P
--
A
T
Y
L
D
-
Y
-
S
V
S
--
L
VK---
K
----
P
Q
-
V
T
V
G
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
H
S
E
R
R
S
YF
H
---
E
D
D
K
F
I
A
D
K
T
K
F
A
L
-
G
Q
G
V
G
V
I
L
C
I
G
E
T
L
E
E
K
K
A
G
K
T
L
D
V
V
E
R
Q
L
-----
N
---
A
---
V
L
-----
E
-----
E
-----
V
-----
K
-----
D
-----
W
---
T
N
V
V
--
V
A
Y
E
P
V
W
A
I
G
T
G
L
--
A
----
A
T
P
E
D
A
Q
--
D
I
H
A
S
I
---------
R
K
F
---------
L
---------
A
---------
S
------
K
LG
D
K
A
A
S
E
L
R
---------
I
----------
L
--
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
S
R
N
----
26
PsiBlast_CBE
76.69
34%
-94
- C5 -
7TIM
1
TPIS_YEAST
B:
[3-235]
---
T
F
F
V
G
G
N
F
K
L
N
G
S
---
K
Q
S
I
K
E
I
V
E
R
L
N
---
T
A
S
I
-
P
---
E
N
V
-
E
V
V
I
C
P
P
--
A
T
Y
L
D
-
Y
-
S
V
S
--
L
VK---
K
----
P
Q
-
V
T
V
G
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
H
S
E
R
R
SYF
H
---
E
D
D
K
F
I
A
D
K
T
K
F
A
L
-
G
Q
G
V
G
V
I
L
C
I
G
E
T
L
E
E
K
K
A
G
K
T
L
D
V
V
E
R
Q
L
-----
N
---
A
---
V
L
-----
E
-----
E
-----
V
-----
K
-----
D
-----
W
---
T
NVV--
V
A
Y
E
P
V
W
A
I
G
T
G
L
--
A
----
A
T
P
E
D
A
Q
--
D
I
H
A
S
I
---------
R
K
F
---------
L
---------
A
---------
S
------
K
LGDKAASEL
R
---------
I
----------
L
--
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
S
R
N
----
33
PsiBlast_CBE
76.47
34%
-105
- C5 -
3YPI
1
TPIS_YEAST
B:
[3-235]
---
T
F
F
V
G
G
N
F
K
L
N
G
S
---
K
Q
S
I
K
E
I
V
E
R
L
N
---
T
A
S
I
-
P
---
E
N
V
-
E
V
V
I
C
P
P
--
A
T
Y
L
D
-
Y
-
S
V
S
--
L
VK---
K
----
P
Q
-
V
T
V
G
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
Q
S
E
R
R
SYF
H
---
E
D
D
K
F
I
A
D
K
T
K
F
A
L
-
G
Q
G
V
G
V
I
L
C
I
G
E
T
L
E
E
K
K
A
G
K
T
L
D
V
V
E
R
Q
L
-----
N
---
A
---
V
L
-----
E
-----
E
-----
V
-----
K
-----
D
-----
W
---
T
NVV--
V
A
Y
E
P
V
W
A
I
G
T
G
L
--
A
----
A
T
P
E
D
A
Q
--
D
I
H
A
S
I
---------
R
K
F
---------
L
---------
A
---------
S
------
K
LGDKAASEL
R
---------
I
----------
L
--
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
S
R
N
----
19
PsiBlast_PDB
76.38
34%
-99
- C5 -
3YPI
1
TPIS_YEAST
A:
[3-235]
---
T
F
F
V
G
G
N
F
K
L
N
G
S
---
K
Q
S
I
K
E
I
V
E
R
L
N
---
T
A
S
I
-
P
---
E
N
V
-
E
V
V
I
C
P
P
--
A
T
Y
L
D
-
Y
-
S
V
S
--
L
VK---
K
----
P
Q
-
V
T
V
G
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
Q
S
E
R
R
S
YF
H
---
E
D
D
K
F
I
A
D
K
T
K
F
A
L
-
G
Q
G
V
G
V
I
L
C
I
G
E
T
L
E
E
K
K
A
G
K
T
L
D
V
V
E
R
Q
L
-----
N
---
A
---
V
L
-----
E
-----
E
-----
V
-----
K
-----
D
-----
W
---
T
N
V
V
--
V
A
Y
E
P
V
W
A
I
G
T
G
L
--
A
----
A
T
P
E
D
A
Q
--
D
I
H
A
S
I
---------
R
K
F
---------
L
---------
A
---------
S
------
K
LG
D
K
A
A
S
E
L
R
---------
I
----------
L
--
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
S
R
N
----
95
PsiBlast_CBE
75.43
34%
-94
- C5 -
2VFE
3
TPIS_PLAFA
A:
[5-236]
----
Y
F
V
A
A
N
W
K
C
N
G
T
---
L
E
S
I
K
S
L
T
N
S
F
N
---
N
L
D
F
-
D
---
P
S
K
-
L
D
V
V
V
F
P
--
V
S
V
H
Y
-
D
-
H
T
R
K
L
L
-----
Q
----
S
K
-
F
S
T
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
S
E
R
R
K
YF
H
---
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
-
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
-----
K
---
A
---
F
V
-----
D
-----
L
-----
I
-----
D
-----
N
-----
F
---
D
N
V
I
--
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
----
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
---------
K
D
T
---------
C
---------
G
---------
E
------
K
---------
Q
A
N
Q
I
R
----
I
----------
L
--
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
E
S
F
V
D
I
I
K
S
A
M
----
10
PsiBlast_PDB
74.34
34%
-93
- C5 -
2YPI
1
TPIS_YEAST
A:
[3-235]
---
T
F
F
V
G
G
N
F
K
L
N
G
S
---
K
Q
S
I
K
E
I
V
E
R
L
N
---
T
A
S
I
-
P
---
E
N
V
-
E
V
V
I
C
P
P
--
A
T
Y
L
D
-
Y
-
S
V
S
--
L
VK---
K
----
P
Q
-
V
T
V
G
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
H
S
E
R
R
S
YF
H
---
E
D
D
K
F
I
A
D
K
T
K
F
A
L
-
G
Q
G
V
G
V
I
L
C
I
G
E
T
L
E
E
K
K
A
G
K
T
L
D
V
V
E
R
Q
L
-----
N
---
A
---
V
L
-----
E
-----
E
-----
V
-----
K
-----
D
-----
W
---
T
N
V
V
--
V
A
Y
E
P
V
W
A
I
G
T
G
L
--
A
----
A
T
P
E
D
A
Q
--
D
I
H
A
S
I
---------
R
K
F
---------
L
---------
A
---------
S
------
K
LG
D
K
A
A
S
E
L
R
---------
I
----------
L
--
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
S
R
N
----
94
PsiBlast_CBE
73.96
34%
-96
- C5 -
2VFE
3
TPIS_PLAFA
B:
[5-236]
----
Y
F
V
A
A
N
W
K
C
N
G
T
---
L
E
S
I
K
S
L
T
N
S
F
N
---
N
L
D
F
-
D
---
P
S
K
-
L
D
V
V
V
F
P
--
V
S
V
H
Y
-
D
-
H
T
R
K
L
L
-----
Q
----
S
K
-
F
S
T
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
S
E
R
R
K
YF
H
---
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
-
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
-----
K
---
A
---
F
V
-----
D
-----
L
-----
I
-----
D
-----
N
-----
F
---
D
N
V
I
--
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
----
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
---------
K
D
T
---------
C
---------
G
---------
E
------
K
---------
Q
A
N
Q
I
R
----
I
----------
L
--
Y
G
G
S
------
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
E
S
F
V
D
I
I
K
S
A
M
----