@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0461: (2015-12-01 )
MRFTLSWLLEHLETNASLEEITDKLTHIGLEVKDVVDNTKLAGFIVAKVLEVTPHPNVDKLKLCKVDNGSKILQIVCGANNVREGLKTVLASLGSTLPESNFTIKPTKIRGVLSEGILCSASELMLAQEKSKGIIELSDDYKVGNKFFNCDPVIDINVTTNRGDCLSVHGIARDLAATGIGTLNSLIYSSAIPAHDTGIQDRSKSGMTRSSSINVKVIDGESFISGVYISNVRNKESPRWLKDRLESVGMRSISAIVDITNYIMMSFGRPMHAYDAKKIEGKLIVRKANNGEKFTGLNGKEYLLNNDISVISDNNNIHAIAGIIGGKCSKCTLETTDVFLESAWFNPISVTKSSRQLNISTDSSYRFARSVDPGFILDGLHFAAQMIVDLCGGKASNVVFAGSLDEADTKVSFDYQDVNKFGSVSVLPDEMFDILTKLGFSTDKKTENNWNVKVPSWRSDVTIPADLVEEVVRIYGYDKIKEEPLIDNVEVEINTHDNLRVLMISRGFHEVFTWSFMSESIAEKFGYSNKLFIIDNPFNNNFNIMRPSIVPNLLQVTADNIVHGMSDLAIFEIGPVYDSLDQPKYSLSGIRTGNNLPRNHYNTDRKIDVFDAKADLIAALELFNVSYGNLTIERAEKEYYHPGKSGTLSFKNKATGYFGELHPNILDLFDIKQKVVGFEMILENMGNLPVSREKFIDYKHQSVKRDFAFIVNRDVEVGKIINMVKKSSELITEVFVFDVYHGNNMEPNKMSIALSVTFCSPTHTLIEEEIQKESSAIVNLVHKNTGGILRYT
Atome Classification :
(20 SA)
.........10........20........30.-.....-..40----..-.----......50........60......-..-70-........80........90........100.......110.......120..-----.....-----130.......140...---.....----150--..---.......160.......170.......180..--..--...190.......200.......210.......220.......230.-.-..-...240.......250.......260.......270.......280.-.......290.....-..300.......310----.......320.......330.......340.......350.......360.......370.......380.......390...-....---400.-...-..----.410.......420.......430.......440........450.......460.......470.......480--...-----.....--.----490-....-------.--..500.......510.......520......-.530.-......540.......550.......560.......-570.....------..580----......------...590..--.....600....-...610.......620.......630..-....-..640.......650.......660.......670.......680...--...-.690.....-.----.700.......710.......720....-..-.-730.......740.......750.......760.......770.......780.......790
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
R
F
T
L
S
W
L
L
E
H
L
ETNA
S
L
E
E
I
T
D
K
L
T
HIG
L
E
V
-
K
D
VVD-NT
K
-----
L
A
-
G
----
F
I
V
A
K
V
L
EVTPHPNVD
K
L
K
L
C
KVD-NG-
S
K
-
I
L
Q
I
V
CGA
N
N
V
R
E
G
L
K
T
V
L
A
S
L
GSTLPESN
F
T
I
K
P
T
K
I
R
G
V
L
SEGILC
S
A
S
E
L
-----
M
L
A
Q
E-----KSK
G
I
I
E
LSDD-YKVG---NKFFN----C----D
P
---
V
I
D
I
N
V
TTNRG
D
C
L
S
V
H
G
I
A
R
D
L
A
A
T
G
I
G
T
L
N
--
S
L
--
I
Y
SSAIPAHDTGIQDRSKSGMTRSS
S
I
N
V
K
V
IDGES
F
I
S
G
V
Y
I
SNVR-N-KE-S
P
R
W
L
K
D
R
L
E
S
V
G
M
R
S
I
S
A
I
V
D
I
T
N
Y
I
M
M
SFGRPMHAYDAKKIE
G
-
K
-
L
I
V
R
KANNGEKFTGL-NGK
E
Y
L
LNN
D
I
S
V
IS----DNN
N
I
H
A
I
A
G
I
IGGKCS
K
C
T
L
E
T
T
D
V
F
L
E
S
AWFN
P
I
S
VTKSS
R
Q
L
N
ISTDSS
Y
R
F
ARSVD
P
G
F
I
L
D
G
L
H
F
A
A
Q
M
I
V
D
L
CGGKA-S
N
V
V
---
F
AGS-LDE-AD----
T
K
V
S
F
D
Y
Q
D
V
N
KFGSVSVL
P
D
E
M
F
D
I
L
T
KLGFS-TDKKTENNW
N
V
KVPSWRSDVTI
P
A
D
L
V
E
E
V
V
R
IYGYDKI----KEE-----PLI
D
N
--
V
----
E
V
E
-
I
NTH-------D--
N
L
R
V
L
M
ISRG
F
H
E
V
F
T
W
S
F
M
S
E
S
I
A
E
KFGYS-
N
K
L
F
I
-
I
DNPFNNNFNIMR
P
S
I
V
P
N
L
L
Q
V
T
A
D
N
I
VHGMS
D
L
A
-
I
F
E
IGPVY------DSL------DQPKYS------LSGIRTGN--NLPRNHYNTD
R
K
-
I
D
V
FDA
K
A
D
L
I
A
A
L
E
L
F
NVSYG
N
L
T
-
I
E
-RA
E
K
-
E
YYHPGKSG
T
L
S
F
KNKATGYFGELHP
N
I
L
D
L
F
D
I
K
Q
K
V
V
G
F
E
M
I
L
E
NM--GNL-PV
S
R
E
K
F
I
D
-
Y
----
K
H
Q
S
V
K
R
D
F
A
F
I
VNRDV
E
V
G
K
I
I
N
M
V
K
K
-
S
S
-
E
-
L
I
T
E
V
F
V
F
D
V
YHGNNMEPN
K
M
S
I
A
L
S
V
T
FCS
P
T
H
T
L
I
E
E
E
I
Q
K
E
S
S
A
I
V
N
L
VHKNTG
G
I
L
RYT
1
PsiBlast_PDB
91.26
32%
-92
- C1 -
4P71
-
SYFB_PSEAE
A:
[1-791]
M
K
F
S
E
K
W
L
R
S
W
A
N
P
Q
V
S
H
D
E
L
V
A
R
L
S
M
V
G
L
E
V
D
A
D
L
P
V
-
A
G
A
-----
F
S
-
G
----
V
V
V
G
E
V
L
S
T
E
Q
H
P
D
A
D
K
L
R
V
C
Q
V
S
-
N
G
-
S
E
-
T
F
Q
V
V
C
G
A
P
N
V
R
A
G
L
K
I
P
F
A
M
I
G
A
E
L
P
D
-
D
F
K
I
K
K
A
K
L
R
G
V
E
S
F
G
M
L
C
S
A
K
E
L
-----
Q
I
S
E
E
-----
N
A
-
G
L
L
E
L
P
A
D
-
A
P
V
G
---
Q
D
V
R
T
Y
L
EL
A
----
D
Y
---
T
I
E
V
G
L
T
P
N
R
G
D
C
L
S
L
A
G
L
A
R
E
V
S
A
I
Y
D
V
P
L
A
--
P
V
--
A
V
D
A
V
A
A
Q
H
D
E
----------
T
R
P
V
E
L
A
A
P
A
A
C
P
R
Y
L
--
G
R
V
I
R
N
V
D
L
S
-
R
P
-
T
P
L
W
M
V
E
R
L
R
R
S
D
I
R
S
I
D
P
V
V
D
V
T
N
Y
V
M
I
E
L
G
Q
P
M
H
A
F
D
L
A
E
I
N
G
-
G
-
V
R
V
R
M
A
E
D
G
E
K
L
V
L
L
-
D
G
Q
E
I
T
L
R
A
D
T
L
V
I
A
----
D
H
Q
R
A
L
A
I
A
G
V
M
G
G
E
H
S
G
V
S
D
S
T
R
D
L
F
L
E
A
A
F
F
D
T
I
A
L
A
G
K
A
R
S
Y
G
L
H
T
D
S
S
H
R
F
E
R
G
V
D
S
Q
L
A
R
K
A
M
E
R
A
T
R
L
I
L
D
I
V
G
G
E
P
-
G
P
I
V
-----
E
Q
-
V
S
E
-
A
H
L
P
K
V
A
P
I
T
L
R
A
E
R
V
T
Q
M
L
G
M
P
L
D
A
A
E
I
V
R
L
L
Q
A
L
E
L
T
-
V
V
A
D
G
E
G
Q
W
S
V
G
V
P
S
H
R
F
D
I
S
L
E
V
D
L
I
E
E
L
A
R
L
Y
G
Y
N
R
L
P
V
R
Y
P
Q
A
-----
R
L
A
P
N
--
N
----
K
P
E
A
R
A
A
L
-------
P
--
L
L
R
R
L
L
V
A
R
G
Y
Q
E
A
I
T
F
S
F
I
D
P
A
L
F
E
L
F
D
P
G
-
T
Q
P
L
T
-
L
A
N
P
I
S
A
D
M
A
A
M
R
S
S
L
W
P
G
L
V
K
A
L
Q
H
N
L
N
R
Q
Q
S
R
V
R
-
L
F
E
S
G
L
R
F
V
G
QL--
E
G
L
------
K
Q
-
E
A
M
------
L
A
G
A
I
C
G
K
--
R
L
P
E
G
W
A
N
G
R
D
G
-
V
D
F
F
D
A
K
A
D
V
E
A
V
L
A
S
A
G
-
A
L
G
D
F
S
-
F
V
-
P
G
E
H
-
P
A
L
H
P
G
Q
T
A
R
I
E
R
E
G
R
L
V
G
Y
L
G
A
L
H
P
E
L
A
K
K
L
D
L
E
Q
P
V
F
L
F
E
L
L
L
A
E
V
V
D
G
H
L
-
P
K
F
R
E
L
----
S
----
R
F
P
E
V
R
R
D
L
A
L
L
V
D
Q
D
V
P
A
Q
D
I
L
T
Q
I
R
A
-
A
A
G
E
-
W
L
T
D
L
R
L
F
D
V
Y
H
G
K
G
I
D
P
H
R
K
S
L
A
V
G
L
T
W
Q
H
P
S
R
T
L
N
D
D
E
V
N
S
T
T
Q
N
I
V
T
S
L
E
E
R
F
N
A
T
L
R
--
4
PsiBlast_PDB
91.06
32%
-90
- C1 -
4P74
-
SYFB_PSEAE
A:
[1-791]
M
K
F
S
E
K
W
L
R
S
W
A
N
P
Q
V
S
H
D
E
L
V
A
R
L
S
M
V
G
L
E
V
D
A
D
L
P
V
-
A
G
A
-----
F
S
-
G
----
V
V
V
G
E
V
L
S
T
E
Q
H
P
D
A
D
K
L
R
V
C
Q
V
S
-
N
G
-
S
E
-
T
F
Q
V
V
C
G
A
P
N
V
R
A
G
L
K
I
P
F
A
M
I
G
A
E
L
P
D
-
D
F
K
I
K
K
A
K
L
R
G
V
E
S
F
G
M
L
C
S
A
K
E
L
-----
Q
I
S
E
E
-----
N
A
-
G
L
L
E
L
P
A
D
-
A
P
V
G
---
Q
D
V
R
T
Y
L
EL
A
----
D
Y
---
T
I
E
V
G
L
T
P
N
R
G
D
C
L
S
L
A
G
L
A
R
E
V
S
A
I
Y
D
V
P
L
A
--
P
V
--
A
V
D
A
V
A
A
Q
H
D
E
----------
T
R
P
V
E
L
A
A
P
A
A
C
P
R
Y
L
--
G
R
V
I
R
N
V
D
L
S
-
R
P
-
T
P
L
W
M
V
E
R
L
R
R
S
D
I
R
S
I
D
P
V
V
D
V
T
N
Y
V
M
I
E
L
G
Q
P
M
H
A
F
D
L
A
E
I
N
G
-
G
-
V
R
V
R
M
A
E
D
G
E
K
L
V
L
L
-
D
G
Q
E
I
T
L
R
A
D
T
L
V
I
A
----
D
H
Q
R
A
L
A
I
A
G
V
M
G
G
E
H
S
G
V
S
D
S
T
R
D
L
F
L
E
A
A
F
F
D
T
I
A
L
A
G
K
A
R
S
Y
G
L
H
T
D
S
S
H
R
F
E
R
G
V
D
S
Q
L
A
R
K
A
M
E
R
A
T
R
L
I
L
D
I
V
G
G
E
P
-
G
P
I
V
-----
E
Q
-
V
S
E
-
A
H
L
P
K
V
A
P
I
T
L
R
A
E
R
V
T
Q
M
L
G
M
P
L
D
A
A
E
I
V
R
L
L
Q
A
L
E
L
T
-
V
V
A
D
G
E
G
Q
W
S
V
G
V
P
S
H
R
F
D
I
S
L
E
V
D
L
I
E
E
L
A
R
L
Y
G
Y
N
R
L
P
V
R
Y
P
Q
A
-----
R
L
A
P
N
--
N
----
K
P
E
A
R
A
A
L
-------
P
--
L
L
R
R
L
L
V
A
R
G
Y
Q
E
A
I
T
F
S
F
I
D
P
A
L
F
E
L
F
D
P
G
-
T
Q
P
L
T
-
L
A
N
P
I
S
A
D
M
A
A
M
R
S
S
L
W
P
G
L
V
K
A
L
Q
H
N
L
N
R
Q
Q
S
R
V
R
-
L
F
E
S
G
L
R
F
V
G
QL--
E
G
L
------
K
Q
-
E
A
M
------
L
A
G
A
I
C
G
K
--
R
L
P
E
G
W
A
N
G
R
D
G
-
V
D
F
F
D
A
K
A
D
V
E
A
V
L
A
S
A
G
-
A
L
G
D
F
S
-
F
V
-
P
G
E
H
-
P
A
L
H
P
G
Q
T
A
R
I
E
R
E
G
R
L
V
G
Y
L
G
A
L
H
P
E
L
A
K
K
L
D
L
E
Q
P
V
F
L
F
E
L
L
L
A
E
V
V
D
G
H
L
-
P
K
F
R
E
L
----
S
----
R
F
P
E
V
R
R
D
L
A
L
L
V
D
Q
D
V
P
A
Q
D
I
L
T
Q
I
R
A
-
A
A
G
E
-
W
L
T
D
L
R
L
F
D
V
Y
H
G
K
G
I
D
P
H
R
K
S
L
A
V
G
L
T
W
Q
H
P
S
R
T
L
N
D
D
E
V
N
S
T
T
Q
N
I
V
T
S
L
E
E
R
F
N
A
T
L
R
--
5
PsiBlast_PDB
90.71
32%
-90
- C1 -
4P75
-
SYFB_PSEAE
A:
[1-791]
M
K
F
S
E
K
W
L
R
S
W
A
N
P
Q
V
S
H
D
E
L
V
A
R
L
S
M
V
G
L
E
V
D
A
D
L
P
V
-
A
G
A
-----
F
S
-
G
----
V
V
V
G
E
V
L
S
T
E
Q
H
P
D
A
D
K
L
R
V
C
Q
V
S
-
N
G
-
S
E
-
T
F
Q
V
V
C
G
A
P
N
V
R
A
G
L
K
I
P
F
A
M
I
G
A
E
L
P
D
-
D
F
K
I
K
K
A
K
L
R
G
V
E
S
F
G
M
L
C
S
A
K
E
L
-----
Q
I
S
E
E
-----
N
A
-
G
L
L
E
L
P
A
D
-
A
P
V
G
---
Q
D
V
R
T
Y
L
EL
A
----
D
Y
---
T
I
E
V
G
L
T
P
N
R
G
D
C
L
S
L
A
G
L
A
R
E
V
S
A
I
Y
D
V
P
L
A
--
P
V
--
A
V
D
A
V
A
A
Q
H
D
E
----------
T
R
P
V
E
L
A
A
P
A
A
C
P
R
Y
L
--
G
R
V
I
R
N
V
D
L
S
-
R
P
-
T
P
L
W
M
V
E
R
L
R
R
S
D
I
R
S
I
D
P
V
V
D
V
T
N
Y
V
M
I
E
L
G
Q
P
M
H
A
F
D
L
A
E
I
N
G
-
G
-
V
R
V
R
M
A
E
D
G
E
K
L
V
L
L
-
D
G
Q
E
I
T
L
R
A
D
T
L
V
I
A
----
D
H
Q
R
A
L
A
I
A
G
V
M
G
G
E
H
S
G
V
S
D
S
T
R
D
L
F
L
E
A
A
F
F
D
T
I
A
L
A
G
K
A
R
S
Y
G
L
H
T
D
S
S
H
R
F
E
R
G
V
D
S
Q
L
A
R
K
A
M
E
R
A
T
R
L
I
L
D
I
V
G
G
E
P
-
G
P
I
V
-----
E
Q
-
V
S
E
-
A
H
L
P
K
V
A
P
I
T
L
R
A
E
R
V
T
Q
M
L
G
M
P
L
D
A
A
E
I
V
R
L
L
Q
A
L
E
L
T
-
V
V
A
D
G
E
G
Q
W
S
V
G
V
P
S
H
R
F
D
I
S
L
E
V
D
L
I
E
E
L
A
R
L
Y
G
Y
N
R
L
P
V
R
Y
P
Q
A
-----
R
L
A
P
N
--
N
----
K
P
E
A
R
A
A
L
-------
P
--
L
L
R
R
L
L
V
A
R
G
Y
Q
E
A
I
T
F
S
F
I
D
P
A
L
F
E
L
F
D
P
G
-
T
Q
P
L
T
-
L
A
N
P
I
S
A
D
M
A
A
M
R
S
S
L
W
P
G
L
V
K
A
L
Q
H
N
L
N
R
Q
Q
S
R
V
R
-
L
F
E
S
G
L
R
F
V
G
QL--
E
G
L
------
K
Q
-
E
A
M
------
L
A
G
A
I
C
G
K
--
R
L
P
E
G
W
A
N
G
R
D
G
-
V
D
F
F
D
A
K
A
D
V
E
A
V
L
A
S
A
G
-
A
L
G
D
F
S
-
F
V
-
P
G
E
H
-
P
A
L
H
P
G
Q
T
A
R
I
E
R
E
G
R
L
V
G
Y
L
G
A
L
H
P
E
L
A
K
K
L
D
L
E
Q
P
V
F
L
F
E
L
L
L
A
E
V
V
D
G
H
L
-
P
K
F
R
E
L
----
S
----
R
F
P
E
V
R
R
D
L
A
L
L
V
D
Q
D
V
P
A
Q
D
I
L
T
Q
I
R
A
-
A
A
G
E
-
W
L
T
D
L
R
L
F
D
V
Y
H
G
K
G
I
D
P
H
R
K
S
L
A
V
G
L
T
W
Q
H
P
S
R
T
L
N
D
D
E
V
N
S
T
T
Q
N
I
V
T
S
L
E
E
R
F
N
A
T
L
R
--
2
PsiBlast_PDB
90.58
32%
-90
- C1 -
4P72
-
SYFB_PSEAE
A:
[1-791]
M
K
F
S
E
K
W
L
R
S
W
A
N
P
Q
V
S
H
D
E
L
V
A
R
L
S
M
V
G
L
E
V
D
A
D
L
P
V
-
A
G
A
-----
F
S
-
G
----
V
V
V
G
E
V
L
S
T
E
Q
H
P
D
A
D
K
L
R
V
C
Q
V
S
-
N
G
-
S
E
-
T
F
Q
V
V
C
G
A
P
N
V
R
A
G
L
K
I
P
F
A
M
I
G
A
E
L
P
D
-
D
F
K
I
K
K
A
K
L
R
G
V
E
S
F
G
M
L
C
S
A
K
E
L
-----
Q
I
S
E
E
-----
N
A
-
G
L
L
E
L
P
A
D
-
A
P
V
G
---
Q
D
V
R
T
Y
L
EL
A
----
D
Y
---
T
I
E
V
G
L
T
P
N
R
G
D
C
L
S
L
A
G
L
A
R
E
V
S
A
I
Y
D
V
P
L
A
--
P
V
--
A
V
D
A
V
A
A
Q
H
D
E
----------
T
R
P
V
E
L
A
A
P
A
A
C
P
R
Y
L
--
G
R
V
I
R
N
V
D
L
S
-
R
P
-
T
P
L
W
M
V
E
R
L
R
R
S
D
I
R
S
I
D
P
V
V
D
V
T
N
Y
V
M
I
E
L
G
Q
P
M
H
A
F
D
L
A
E
I
N
G
-
G
-
V
R
V
R
M
A
E
D
G
E
K
L
V
L
L
-
D
G
Q
E
I
T
L
R
A
D
T
L
V
I
A
----
D
H
Q
R
A
L
A
I
A
G
V
M
G
G
E
H
S
G
V
S
D
S
T
R
D
L
F
L
E
A
A
F
F
D
T
I
A
L
A
G
K
A
R
S
Y
G
L
H
T
D
S
S
H
R
F
E
R
G
V
D
S
Q
L
A
R
K
A
M
E
R
A
T
R
L
I
L
D
I
V
G
G
E
P
-
G
P
I
V
-----
E
Q
-
V
S
E
-
A
H
L
P
K
V
A
P
I
T
L
R
A
E
R
V
T
Q
M
L
G
M
P
L
D
A
A
E
I
V
R
L
L
Q
A
L
E
L
T
-
V
V
A
D
G
E
G
Q
W
S
V
G
V
P
S
H
R
F
D
I
S
L
E
V
D
L
I
E
E
L
A
R
L
Y
G
Y
N
R
L
P
V
R
Y
P
Q
A
-----
R
L
A
P
N
--
N
----
K
P
E
A
R
A
A
L
-------
P
--
L
L
R
R
L
L
V
A
R
G
Y
Q
E
A
I
T
F
S
F
I
D
P
A
L
F
E
L
F
D
P
G
-
T
Q
P
L
T
-
L
A
N
P
I
S
A
D
M
A
A
M
R
S
S
L
W
P
G
L
V
K
A
L
Q
H
N
L
N
R
Q
Q
S
R
V
R
-
L
F
E
S
G
L
R
F
V
G
QL--
E
G
L
------
K
Q
-
E
A
M
------
L
A
G
A
I
C
G
K
--
R
L
P
E
G
W
A
N
G
R
D
G
-
V
D
F
F
D
A
K
A
D
V
E
A
V
L
A
S
A
G
-
A
L
G
D
F
S
-
F
V
-
P
G
E
H
-
P
A
L
H
P
G
Q
T
A
R
I
E
R
E
G
R
L
V
G
Y
L
G
A
L
H
P
E
L
A
K
K
L
D
L
E
Q
P
V
F
L
F
E
L
L
L
A
E
V
V
D
G
H
L
-
P
K
F
R
E
L
----
S
----
R
F
P
E
V
R
R
D
L
A
L
L
V
D
Q
D
V
P
A
Q
D
I
L
T
Q
I
R
A
-
A
A
G
E
-
W
L
T
D
L
R
L
F
D
V
Y
H
G
K
G
I
D
P
H
R
K
S
L
A
V
G
L
T
W
Q
H
P
S
R
T
L
N
D
D
E
V
N
S
T
T
Q
N
I
V
T
S
L
E
E
R
F
N
A
T
L
R
--
3
PsiBlast_PDB
90.31
32%
-93
- C1 -
4P73
-
SYFB_PSEAE
A:
[1-791]
M
K
F
S
E
K
W
L
R
S
W
A
N
P
Q
V
S
H
D
E
L
V
A
R
L
S
M
V
G
L
E
V
D
A
D
L
P
V
-
A
G
A
-----
F
S
-
G
----
V
V
V
G
E
V
L
S
T
E
Q
H
P
D
A
D
K
L
R
V
C
Q
V
S
-
N
G
-
S
E
-
T
F
Q
V
V
C
G
A
P
N
V
R
A
G
L
K
I
P
F
A
M
I
G
A
E
L
P
D
-
D
F
K
I
K
K
A
K
L
R
G
V
E
S
F
G
M
L
C
S
A
K
E
L
-----
Q
I
S
E
E
-----
N
A
-
G
L
L
E
L
P
A
D
-
A
P
V
G
---
Q
D
V
R
T
Y
L
EL
A
----
D
Y
---
T
I
E
V
G
L
T
P
N
R
G
D
C
L
S
L
A
G
L
A
R
E
V
S
A
I
Y
D
V
P
L
A
--
P
V
--
A
V
D
A
V
A
A
Q
H
D
E
----------
T
R
P
V
E
L
A
A
P
A
A
C
P
R
Y
L
--
G
R
V
I
R
N
V
D
L
S
-
R
P
-
T
P
L
W
M
V
E
R
L
R
R
S
D
I
R
S
I
D
P
V
V
D
V
T
N
Y
V
M
I
E
L
G
Q
P
M
H
A
F
D
L
A
E
I
N
G
-
G
-
V
R
V
R
M
A
E
D
G
E
K
L
V
L
L
-
D
G
Q
E
I
T
L
R
A
D
T
L
V
I
A
----
D
H
Q
R
A
L
A
I
A
G
V
M
G
G
E
H
S
G
V
S
D
S
T
R
D
L
F
L
E
A
A
F
F
D
T
I
A
L
A
G
K
A
R
S
Y
G
L
H
T
D
S
S
H
R
F
E
R
G
V
D
S
Q
L
A
R
K
A
M
E
R
A
T
R
L
I
L
D
I
V
G
G
E
P
-
G
P
I
V
-----
E
Q
-
V
S
E
-
A
H
L
P
K
V
A
P
I
T
L
R
A
E
R
V
T
Q
M
L
G
M
P
L
D
A
A
E
I
V
R
L
L
Q
A
L
E
L
T
-
V
V
A
D
G
E
G
Q
W
S
V
G
V
P
S
H
R
F
D
I
S
L
E
V
D
L
I
E
E
L
A
R
L
Y
G
Y
N
R
L
P
V
R
Y
P
Q
A
-----
R
L
A
P
N
--
N
----
K
P
E
A
R
A
A
L
-------
P
--
L
L
R
R
L
L
V
A
R
G
Y
Q
E
A
I
T
F
S
F
I
D
P
A
L
F
E
L
F
D
P
G
-
T
Q
P
L
T
-
L
A
N
P
I
S
A
D
M
A
A
M
R
S
S
L
W
P
G
L
V
K
A
L
Q
H
N
L
N
R
Q
Q
S
R
V
R
-
L
F
E
S
G
L
R
F
V
G
QL--
E
G
L
------
K
Q
-
E
A
M
------
L
A
G
A
I
C
G
K
--
R
L
P
E
G
W
A
N
G
R
D
G
-
V
D
F
F
D
A
K
A
D
V
E
A
V
L
A
S
A
G
-
A
L
G
D
F
S
-
F
V
-
P
G
E
H
-
P
A
L
H
P
G
Q
T
A
R
I
E
R
E
G
R
L
V
G
Y
L
G
A
L
H
P
E
L
A
K
K
L
D
L
E
Q
P
V
F
L
F
E
L
L
L
A
E
V
V
D
G
H
L
-
P
K
F
R
E
L
----
S
----
R
F
P
E
V
R
R
D
L
A
L
L
V
D
Q
D
V
P
A
Q
D
I
L
T
Q
I
R
A
-
A
A
G
E
-
W
L
T
D
L
R
L
F
D
V
Y
H
G
K
G
I
D
P
H
R
K
S
L
A
V
G
L
T
W
Q
H
P
S
R
T
L
N
D
D
E
V
N
S
T
T
Q
N
I
V
T
S
L
E
E
R
F
N
A
T
L
R
--
6
PsiBlast_PDB
86.34
32%
-98
- C1 -
3PCO
-
SYFB_ECOLI
B:
[1-794]
M
K
F
S
E
L
W
L
R
E
W
V
N
P
A
I
D
S
D
A
L
A
N
Q
I
T
M
A
G
L
E
V
-
D
G
V
----
E
P
-----
V
A
-
G
SFHG
V
V
V
G
E
V
V
E
C
A
Q
H
P
N
A
D
K
L
R
V
T
K
V
N
V
G
G
-
D
R
-
L
L
D
I
V
C
G
A
P
N
C
R
Q
G
L
R
V
A
V
A
T
I
G
A
V
L
P
-
G
D
F
K
I
K
A
A
K
L
R
G
E
P
S
E
G
M
L
C
S
F
S
E
L
-----
G
I
S
D
D
-----
H
S
-
G
I
I
E
L
P
A
D
-
A
P
I
G
TD
I
R
E
Y
L
K
----
L
----
D
D
N--
T
I
E
I
S
V
T
P
N
R
A
D
C
L
G
I
I
G
V
A
R
D
V
A
-----
V
L
N
--
Q
L
PL
V
Q
P
E
I
V
P
V
G
A
T
-
I
D
D
--------
T
L
P
I
T
V
E
A
P
E
A
C
P
R
Y
L
G
R
V
V
K
G
I
N
-
V
-
K
A
P
T
P
L
W
M
K
E
K
L
R
R
C
G
I
R
S
I
D
A
V
V
D
V
T
N
Y
V
L
L
E
L
G
Q
P
M
H
A
F
D
K
D
R
I
E
G
-
G
-
I
V
V
R
M
A
K
E
G
E
T
L
V
L
L
-
D
G
T
E
A
K
L
N
A
D
T
L
V
I
A
----
D
H
N
K
A
L
A
M
G
G
I
F
G
G
E
H
S
G
V
N
D
E
T
Q
N
V
L
L
E
C
A
F
F
S
P
L
S
I
T
G
R
A
R
R
H
G
L
H
T
D
A
S
H
R
Y
E
R
G
V
D
P
A
L
Q
H
K
A
M
E
R
A
T
R
L
L
I
D
I
C
G
G
E
A
-
G
P
V
I
D
I
T
N
E
A
T
-
L
P
K
-
R
A
----
T
-
I
T
L
R
R
S
K
L
D
R
L
I
G
H
H
I
A
D
E
Q
V
T
D
I
L
R
R
L
G
C
E
V
T
E
G
K
D
E
--
W
Q
A
V
A
P
S
W
R
F
D
M
E
I
E
E
D
L
V
E
E
V
A
R
V
Y
G
Y
N
N
I
----
P
D
E
-----
P
V
--
Q
--
A
----
S
L
I
-
M
G
T
H
REA
D
L
S
L
K
--
R
V
K
T
L
L
N
D
K
G
Y
Q
E
V
I
T
Y
S
F
V
D
P
K
V
Q
Q
M
I
H
P
G
-
V
E
A
L
L
-
L
P
S
P
I
S
V
E
M
S
A
M
R
L
S
L
W
T
G
L
L
A
T
V
V
Y
N
Q
N
R
Q
Q
N
R
V
R
-
I
F
E
S
G
L
R
F
------
V
P
D
------
T
Q
A
P
L
G
IRQ
D
L
M
L
A
G
V
I
C
G
N
--
R
Y
-
E
E
H
W
N
L
A
K
E
T
V
D
F
Y
D
L
K
G
D
L
E
S
V
L
D
L
----
T
G
K
L
N
E
V
E
F
R
A
E
A
N
P
A
L
H
P
G
Q
S
A
A
I
Y
L
K
G
E
R
I
G
F
V
G
V
V
H
P
E
L
E
R
K
L
D
L
N
G
R
T
L
V
F
E
L
E
W
N
K
L
--
A
D
R
-
V
V
P
Q
A
R
E
I
S
------
R
F
P
A
N
R
R
D
I
A
V
V
V
A
E
N
V
P
A
A
D
I
L
S
E
C
K
K
V
G
V
-
N
-
Q
V
V
G
V
N
L
F
D
V
Y
R
G
K
G
V
A
E
G
Y
K
S
L
A
I
S
L
I
L
Q
D
T
S
R
T
L
E
E
E
E
I
A
A
T
V
A
K
C
V
E
A
L
K
E
R
F
Q
A
S
L
R
D
-
7
PsiBlast_PDB
85.07
30%
-94
- C1 -
2RHS
1
SYFB_STAHJ
B:
[1-783]
M
L
I
S
N
E
W
L
K
D
Y
V
D
A
G
V
K
V
E
D
L
A
E
R
I
T
R
T
G
I
E
V
-
D
N
M
I
D
-
Y
S
K
D----
I
K
-
N
----
L
V
V
G
Y
I
Q
S
K
E
K
-------
N
I
C
Q
V
D
-
I
G
-
E
E
E
P
V
Q
I
V
C
G
A
P
N
V
D
A
G
Q
H
V
I
V
A
K
V
G
G
R
L
P
-
G
G
I
K
I
K
R
A
K
---
E
R
S
E
G
M
I
C
S
L
Q
E
I
GISSN
V
V
P
K
A
-----
Y
E
N
G
I
F
V
F
P
T
E
-
V
E
P
G
---
T
D
A
L
T
----
A
L
YLN
D
Q
---
V
M
E
F
D
L
T
P
N
R
A
D
A
L
S
M
V
G
T
A
Y
E
V
A
A
-------------
L
Y
Q
T
E
M
T
K
P
E
T
Q
S
N
E
T
S
E
S
A
-
T
N
E
L
S
V
T
I
D
N
P
E
K
V
P
Y
Y
S
A
R
V
V
K
N
V
S
-
I
-
E
P
-
S
P
I
W
V
Q
A
R
L
I
K
A
G
I
R
P
I
N
N
V
V
D
I
S
N
Y
V
L
L
E
Y
G
Q
P
L
H
M
F
D
Q
D
H
I
G
S
-
K
E
I
V
V
R
Q
A
K
D
E
E
T
M
T
T
L
D
N
N
E
R
K
L
V
D
T
D
I
-
V
I
S
----
N
G
Q
E
P
I
A
L
A
G
V
M
G
G
D
F
S
E
V
T
E
Q
T
T
N
V
V
I
E
G
A
I
F
D
P
V
S
I
R
H
T
S
R
R
L
N
L
R
S
E
A
S
S
R
F
E
K
G
I
A
T
E
F
V
D
E
A
V
D
R
A
C
Y
L
L
Q
E
L
A
S
G
E
V
L
Q
D
R
V
---
S
S
G
D
-
L
G
S
-
F
V
----
T
P
I
D
I
T
A
E
K
V
N
K
T
I
G
F
N
L
S
N
D
E
I
Q
S
I
F
R
Q
L
G
F
E
-
T
T
L
K
G
E
-
T
L
T
V
N
V
P
S
R
R
K
D
I
T
I
K
E
D
L
I
E
E
V
A
R
I
Y
G
Y
D
E
I
----
P
S
S
L
----
P
V
F
G
E
--
V
TSG-
E
L
T
-
D
R
Q
H
-------
K
T
R
T
L
K
E
T
L
E
G
A
G
L
N
Q
A
I
T
Y
S
L
V
S
K
D
H
A
K
D
F
A
L
Q
-
E
R
P
T
I
S
L
L
M
P
M
S
E
A
H
A
T
L
R
Q
S
L
L
P
H
L
I
E
A
T
A
Y
N
V
A
R
K
N
K
D
V
R
-
L
Y
E
I
G
R
V
F
F
G
NGEG
E
L
P
------
D
E
V
E
Y
-------
L
S
G
I
L
T
G
E
--
Y
V
V
N
A
W
Q
G
K
K
E
E
-
I
D
F
F
I
A
K
G
V
V
D
R
V
A
E
K
L
N
L
E
F
---
S
-
Y
K
-
A
G
K
I
-
E
G
L
H
P
G
R
T
A
I
V
S
L
G
G
A
G
I
G
F
I
G
E
L
H
P
Q
V
A
A
D
N
D
L
K
R
T
Y
V
-
F
E
L
N
Y
D
A
M
--
M
Q
V
-
A
V
G
---
Y
I
N
-
Y
E
Q
IP
K
F
P
G
V
T
R
D
I
A
L
E
V
N
H
D
V
P
S
S
E
L
K
Q
I
I
H
N
-
N
G
-
E
D
I
L
Q
S
T
L
V
F
D
V
Y
E
G
E
H
L
E
K
G
K
K
S
V
A
I
R
L
N
Y
L
D
----
L
T
D
E
R
V
S
K
I
H
D
K
I
L
E
A
L
Q
A
Q
G
A
T
I
R
---
9
PsiBlast_PDB
84.85
27%
-90
- C1 -
1PYS
1
SYFB_THET8
B:
[1-779]
M
R
V
P
F
S
W
L
K
A
Y
V
P
E
L
E
S
P
E
V
L
E
E
R
L
A
G
L
G
F
E
T
-
D
R
I
E
R
-
V
F
P
-----
I
P
R
G
----
V
V
F
A
R
V
L
E
A
H
P
I
P
G
T
-
R
L
K
R
L
V
L
D
-
A
G
--
R
-
T
V
E
V
V
S
G
A
E
N
A
R
K
G
I
G
V
A
L
A
L
P
G
T
E
L
P
G
L
G
Q
K
V
G
E
R
V
I
Q
G
V
R
S
F
G
M
A
L
S
P
R
E
L
-----
G
V
G
-
E
-----
Y
G
G
G
L
L
E
F
P
E
D
A
L
P
P
G
---
T
P
L
S
E
----
A
----
W
P
E
E
V
V
L
D
L
E
V
T
P
N
R
P
D
A
L
G
L
L
G
L
A
R
D
L
H
A
L
G
Y
A
L
V
E
P
E
A
A
--
L
K
A
E
A
L
P
L
---------------
P
F
A
L
K
V
E
D
P
E
G
A
P
H
F
T
L
G
Y
A
F
G
L
R
-
V
-
A
P
-
S
P
L
W
M
Q
R
A
L
F
A
A
G
M
R
P
I
N
N
V
V
D
V
T
N
Y
V
M
L
E
R
A
Q
P
M
H
A
F
D
L
R
F
V
G
E
-
G
-
I
A
V
R
R
A
R
E
G
E
R
L
K
T
L
-
D
G
V
E
R
T
L
H
P
E
D
L
V
I
A
G
W
R
G
E
E
S
F
P
L
G
L
A
G
V
M
G
G
A
E
S
E
V
R
E
D
T
E
A
I
A
L
E
V
A
C
F
D
P
V
S
I
R
K
T
A
R
R
H
G
L
R
T
E
A
S
H
R
F
E
R
G
V
D
P
L
G
Q
V
P
A
Q
R
R
A
L
S
L
L
Q
A
L
A
G
A
R
V
-
A
E
A
L
---
L
E
A
G
-
S
P
K
-
P
P
----
E
A
I
P
F
R
P
E
Y
A
N
R
L
L
G
T
S
Y
P
E
A
E
Q
I
A
I
L
K
R
L
G
C
R
-
V
E
G
E
G
-
P
T
Y
R
V
T
P
P
S
H
R
L
D
L
R
L
E
E
D
L
V
E
E
V
A
R
I
Q
G
Y
E
T
I
----
P
L
A
L
P
A
F
F
P
A
P
D
N
RG
V
----
E
A
P
-
Y
R
K
E
-------
Q
--
R
L
R
E
V
L
S
G
L
G
F
Q
E
V
Y
T
Y
S
F
M
D
P
E
D
A
R
R
F
R
L
D
-
P
P
R
L
L
-
L
L
N
P
L
A
P
E
K
A
A
L
R
T
H
L
F
P
G
L
V
R
V
L
K
E
N
L
D
L
D
R
P
E
R
A
L
L
F
E
V
G
R
V
F
------
R
E
R
------
E
E
--
T
H
------
L
A
G
L
L
F
G
E
GV
G
L
P
---
W
A
K
E
R
L
-
S
G
Y
F
L
L
K
G
Y
L
E
A
L
F
A
R
L
G
L
A
F
---
R
-
V
E
-
A
Q
A
F
-
P
F
L
H
P
G
V
S
G
R
V
L
V
E
G
E
E
V
G
F
L
G
A
L
H
P
E
I
A
Q
E
L
E
L
P
-
P
V
H
L
F
E
L
R
L
------
P
L
-
P
D
K
P
L
A
F
Q
D
P
S
----
R
H
P
A
A
F
R
D
L
A
V
V
V
P
A
P
T
P
Y
G
E
V
E
A
L
V
R
E
-
A
A
G
P
-
Y
L
E
S
L
A
L
F
D
L
Y
Q
G
P
P
L
P
E
G
H
K
S
L
A
F
H
L
R
F
R
H
P
K
R
T
L
R
D
E
E
V
E
E
A
V
S
R
V
A
E
A
L
R
A
R
G
F
G
L
R
G
L
D
15
PsiBlast_PDB
84.41
27%
-89
- C1 -
2ALY
2
SYFB_THETH
B:
[1-779]
M
R
V
P
F
S
W
L
K
A
Y
V
P
E
L
E
S
P
E
V
L
E
E
R
L
A
G
L
G
F
E
T
-
D
R
I
E
R
-
V
F
P
-----
I
P
R
G
----
V
V
F
A
R
V
L
E
A
H
P
I
P
G
T
-
R
L
K
R
L
V
L
D
-
A
G
--
R
-
T
V
E
V
V
S
G
A
E
N
A
R
K
G
I
G
V
A
L
A
L
P
G
T
E
L
P
G
L
G
Q
K
V
G
E
R
V
I
Q
G
V
R
S
F
G
M
A
L
S
P
R
E
L
-----
G
V
G
-
E
-----
Y
G
G
G
L
L
E
F
P
E
D
A
L
P
P
G
---
T
P
L
S
E
----
A
----
W
P
E
E
V
V
L
D
L
E
V
T
P
N
R
P
D
A
L
G
L
L
G
L
A
R
D
L
H
A
L
G
Y
A
L
V
E
P
E
A
A
--
L
K
A
E
A
L
P
L
---------------
P
F
A
L
K
V
E
D
P
E
G
A
P
H
F
T
L
G
Y
A
F
G
L
R
-
V
-
A
P
-
S
P
L
W
M
Q
R
A
L
F
A
A
G
M
R
P
I
N
N
V
V
D
V
T
N
Y
V
M
L
E
R
A
Q
P
M
H
A
F
D
L
R
F
V
G
E
-
G
-
I
A
V
R
R
A
R
E
G
E
R
L
K
T
L
-
D
G
V
E
R
T
L
H
P
E
D
L
V
I
A
G
W
R
G
E
E
S
F
P
L
G
L
A
G
V
M
G
G
A
E
S
E
V
R
E
D
T
E
A
I
A
L
E
V
A
C
F
D
P
V
S
I
R
K
T
A
R
R
H
G
L
R
T
E
A
S
H
R
F
E
R
G
V
D
P
L
G
Q
V
P
A
Q
R
R
A
L
S
L
L
Q
A
L
A
G
A
R
V
-
A
E
A
L
---
L
E
A
G
-
S
P
K
-
P
P
----
E
A
I
P
F
R
P
E
Y
A
N
R
L
L
G
T
S
Y
P
E
A
E
Q
I
A
I
L
K
R
L
G
C
R
-
V
E
G
E
G
-
P
T
Y
R
V
T
P
P
S
H
R
L
D
L
R
L
E
E
D
L
V
E
E
V
A
R
I
Q
G
Y
E
T
I
----
P
L
A
L
P
A
F
F
P
A
P
D
N
RG
V
----
E
A
P
-
Y
R
K
E
-------
Q
--
R
L
R
E
V
L
S
G
L
G
F
Q
E
V
Y
T
Y
S
F
M
D
P
E
D
A
R
R
F
R
L
D
-
P
P
R
L
L
-
L
L
N
P
L
A
P
E
K
A
A
L
R
T
H
L
F
P
G
L
V
R
V
L
K
E
N
L
D
L
D
R
P
E
R
A
L
L
F
E
V
G
R
V
F
------
R
E
R
------
E
E
--
T
H
------
L
A
G
L
L
F
G
E
GV
G
L
P
---
W
A
K
E
R
L
-
S
G
Y
F
L
L
K
G
Y
L
E
A
L
F
A
R
L
G
L
A
F
---
R
-
V
E
-
A
Q
A
F
-
P
F
L
H
P
G
V
S
G
R
V
L
V
E
G
E
E
V
G
F
L
G
A
L
H
P
E
I
A
Q
E
L
E
L
P
-
P
V
H
L
F
E
L
R
L
------
P
L
-
P
D
K
P
L
A
F
Q
D
P
S
----
R
H
P
A
A
F
R
D
L
A
V
V
V
P
A
P
T
P
Y
G
E
V
E
A
L
V
R
E
-
A
A
G
P
-
Y
L
E
S
L
A
L
F
D
L
Y
Q
G
P
P
L
P
E
G
H
K
S
L
A
F
H
L
R
F
R
H
P
K
R
T
L
R
D
E
E
V
E
E
A
V
S
R
V
A
E
A
L
R
A
R
G
F
G
L
R
G
L
D
23
HHSearch
84.00
31%
-89
* C1 *
3PCO
-
SYFB_ECOLI
B:
[1-795]
M
K
F
S
E
L
W
L
R
E
W
V
N
P
A
I
D
S
D
A
L
A
N
Q
I
T
M
A
G
L
E
V
-
D
G
V
E
P
V
A
G
S
-----
F
H
-
G
----
V
V
V
G
E
V
V
E
C
A
Q
H
P
N
A
D
K
L
R
V
T
K
V
N
-
V
G
G
D
R
-
L
L
D
I
V
C
G
A
P
N
C
R
Q
G
L
R
V
A
V
A
T
I
G
A
V
L
P
G
D
-
F
K
I
K
A
A
K
L
R
G
E
P
S
E
G
M
L
C
S
F
S
E
L
-----
G
I
S
D
------
D
H
S
G
I
I
E
L
P
A
D
-
A
P
I
G
---
T
D
I
R
E
Y
L
KL
D
----
D
N
---
T
I
E
I
S
V
T
P
N
R
A
D
C
L
G
I
I
G
V
A
R
D
V
A
V
L
N
Q
L
P
L
V
--
Q
P
--
E
I
V
P
V
G
A
T
I
------------
D
D
T
L
P
I
T
V
E
A
P
E
A
C
P
R
Y
L
G
R
V
V
K
G
I
N
-
V
K
A
P
-
T
P
L
W
M
K
E
K
L
R
R
C
G
I
R
S
I
D
A
V
V
D
V
T
N
Y
V
L
L
E
L
G
Q
P
M
H
A
F
D
K
D
R
I
E
G
-
G
-
I
V
V
R
M
A
K
E
G
E
T
L
V
L
L
-
D
G
T
E
A
K
L
N
A
D
T
L
V
I
A
----
D
H
N
K
A
L
A
M
G
G
I
F
G
G
E
H
S
G
V
N
D
E
T
Q
N
V
L
L
E
C
A
F
F
S
P
L
S
I
T
G
R
A
R
R
H
G
L
H
T
D
A
S
H
R
Y
E
R
G
V
D
P
A
L
Q
H
K
A
M
E
R
A
T
R
L
L
I
D
I
C
G
G
E
A
-
G
P
V
I
---
D
I
T
N
E
A
T
L
P
K
R
----
A
T
I
T
L
R
R
S
K
L
D
R
L
I
G
H
H
I
A
D
E
Q
V
T
D
I
L
R
R
L
G
C
E
-
V
T
E
-
G
K
D
E
W
Q
A
V
A
P
S
W
R
F
D
M
E
I
E
E
D
L
V
E
E
V
A
R
V
Y
G
Y
N
N
I
----
P
D
E
-----
P
V
Q
A
S
L-
I
MGTH
R
E
A
-
D
L
S
L
-------
K
--
R
V
K
T
L
L
N
D
K
G
Y
Q
E
V
I
T
Y
S
F
V
D
P
K
V
Q
Q
M
I
H
P
G
-
V
E
A
L
L
-
L
P
S
P
I
S
V
E
M
S
A
M
R
L
S
L
W
T
G
L
L
A
T
V
V
Y
N
Q
N
R
Q
Q
N
R
V
R
-
I
F
E
S
G
L
R
F
------
V
P
D
TQAPLG
I
R
Q
D
L
M
------
L
A
G
V
I
C
G
N
--
R
Y
E
E
H
W
N
L
A
K
E
T
-
V
D
F
Y
D
L
K
G
D
L
E
S
V
L
D
L
T
G
K
L
N
-
E
V
E
-
F
R
-
A
E
A
N
-
P
A
L
H
P
G
Q
S
A
A
I
Y
L
K
G
E
R
I
G
F
V
G
V
V
H
P
E
L
E
R
K
L
D
L
N
G
R
T
L
V
F
E
L
E
W
N
K
L
--
A
D
R
---
V
V
P
Q
A
R
E
I
S
----
R
F
P
A
N
R
R
D
I
A
V
V
V
A
E
N
V
P
A
A
D
I
L
S
E
C
K
K
-
V
G
-
V
N
Q
V
V
G
V
N
L
F
D
V
Y
R
G
K
G
V
A
E
G
Y
K
S
L
A
I
S
L
I
L
Q
D
T
S
R
T
L
E
E
E
E
I
A
A
T
V
A
K
C
V
E
A
L
K
E
R
F
Q
A
S
L
R
D
-
18
PsiBlast_PDB
83.94
27%
-89
- C1 -
3TEH
1
SYFB_THETH
B:
[1-779]
M
R
V
P
F
S
W
L
K
A
Y
V
P
E
L
E
S
P
E
V
L
E
E
R
L
A
G
L
G
F
E
T
-
D
R
I
E
R
-
V
F
P
-----
I
P
R
G
----
V
V
F
A
R
V
L
E
A
H
P
I
P
G
T
-
R
L
K
R
L
V
L
D
-
A
G
--
R
-
T
V
E
V
V
S
G
A
E
N
A
R
K
G
I
G
V
A
L
A
L
P
G
T
E
L
P
G
L
G
Q
K
V
G
E
R
V
I
Q
G
V
R
S
F
G
M
A
L
S
P
R
E
L
-----
G
V
G
-
E
-----
Y
G
G
G
L
L
E
F
P
E
D
A
L
P
P
G
---
T
P
L
S
E
----
A
----
W
P
E
E
V
V
L
D
L
E
V
T
P
N
R
P
D
A
L
G
L
L
G
L
A
R
D
L
H
A
L
G
Y
A
L
V
E
P
E
A
A
--
L
K
A
E
A
L
P
L
---------------
P
F
A
L
K
V
E
D
P
E
G
A
P
H
F
T
L
G
Y
A
F
G
L
R
-
V
-
A
P
-
S
P
L
W
M
Q
R
A
L
F
A
A
G
M
R
P
I
N
N
V
V
D
V
T
N
Y
V
M
L
E
R
A
Q
P
M
H
A
F
D
L
R
F
V
G
E
-
G
-
I
A
V
R
R
A
R
E
G
E
R
L
K
T
L
-
D
G
V
E
R
T
L
H
P
E
D
L
V
I
A
G
W
R
G
E
E
S
F
P
L
G
L
A
G
V
M
G
G
A
E
S
E
V
R
E
D
T
E
A
I
A
L
E
V
A
C
F
D
P
V
S
I
R
K
T
A
R
R
H
G
L
R
T
E
A
S
H
R
F
E
R
G
V
D
P
L
G
Q
V
P
A
Q
R
R
A
L
S
L
L
Q
A
L
A
G
A
R
V
-
A
E
A
L
---
L
E
A
G
-
S
P
K
-
P
P
----
E
A
I
P
F
R
P
E
Y
A
N
R
L
L
G
T
S
Y
P
E
A
E
Q
I
A
I
L
K
R
L
G
C
R
-
V
E
G
E
G
-
P
T
Y
R
V
T
P
P
S
H
R
L
D
L
R
L
E
E
D
L
V
E
E
V
A
R
I
Q
G
Y
E
T
I
----
P
L
A
L
P
A
F
F
P
A
P
D
N
RG
V
----
E
A
P
-
Y
R
K
E
-------
Q
--
R
L
R
E
V
L
S
G
L
G
F
Q
E
V
Y
T
Y
S
F
M
D
P
E
D
A
R
R
F
R
L
D
-
P
P
R
L
L
-
L
L
N
P
L
A
P
E
K
A
A
L
R
T
H
L
F
P
G
L
V
R
V
L
K
E
N
L
D
L
D
R
P
E
R
A
L
L
F
E
V
G
R
V
F
------
R
E
R
------
E
E
--
T
H
------
L
A
G
L
L
F
G
E
GV
G
L
P
---
W
A
K
E
R
L
-
S
G
Y
F
L
L
K
G
Y
L
E
A
L
F
A
R
L
G
L
A
F
---
R
-
V
E
-
A
Q
A
F
-
P
F
L
H
P
G
V
S
G
R
V
L
V
E
G
E
E
V
G
F
L
G
A
L
H
P
E
I
A
Q
E
L
E
L
P
-
P
V
H
L
F
E
L
R
L
------
P
L
-
P
D
K
P
L
A
F
Q
D
P
S
----
R
H
P
A
A
F
R
D
L
A
V
V
V
P
A
P
T
P
Y
G
E
V
E
A
L
V
R
E
-
A
A
G
P
-
Y
L
E
S
L
A
L
F
D
L
Y
Q
G
P
P
L
P
E
G
H
K
S
L
A
F
H
L
R
F
R
H
P
K
R
T
L
R
D
E
E
V
E
E
A
V
S
R
V
A
E
A
L
R
A
R
G
F
G
L
R
G
L
D
17
PsiBlast_PDB
83.92
27%
-90
- C1 -
3HFZ
1
SYFB_THET8
B:
[1-779]
M
R
V
P
F
S
W
L
K
A
Y
V
P
E
L
E
S
P
E
V
L
E
E
R
L
A
G
L
G
F
E
T
-
D
R
I
E
R
-
V
F
P
-----
I
P
R
G
----
V
V
F
A
R
V
L
E
A
H
P
I
P
G
T
-
R
L
K
R
L
V
L
D
-
A
G
--
R
-
T
V
E
V
V
S
G
A
E
N
A
R
K
G
I
G
V
A
L
A
L
P
G
T
E
L
P
G
L
G
Q
K
V
G
E
R
V
I
Q
G
V
R
S
F
G
M
A
L
S
P
R
E
L
-----
G
V
G
-
E
-----
Y
G
G
G
L
L
E
F
P
E
D
A
L
P
P
G
---
T
P
L
S
E
----
A
----
W
P
E
E
V
V
L
D
L
E
V
T
P
N
R
P
D
A
L
G
L
L
G
L
A
R
D
L
H
A
L
G
Y
A
L
V
E
P
E
A
A
--
L
K
A
E
A
L
P
L
---------------
P
F
A
L
K
V
E
D
P
E
G
A
P
H
F
T
L
G
Y
A
F
G
L
R
-
V
-
A
P
-
S
P
L
W
M
Q
R
A
L
F
A
A
G
M
R
P
I
N
N
V
V
D
V
T
N
Y
V
M
L
E
R
A
Q
P
M
H
A
F
D
L
R
F
V
G
E
-
G
-
I
A
V
R
R
A
R
E
G
E
R
L
K
T
L
-
D
G
V
E
R
T
L
H
P
E
D
L
V
I
A
G
W
R
G
E
E
S
F
P
L
G
L
A
G
V
M
G
G
A
E
S
E
V
R
E
D
T
E
A
I
A
L
E
V
A
C
F
D
P
V
S
I
R
K
T
A
R
R
H
G
L
R
T
E
A
S
H
R
F
E
R
G
V
D
P
L
G
Q
V
P
A
Q
R
R
A
L
S
L
L
Q
A
L
A
G
A
R
V
-
A
E
A
L
---
L
E
A
G
-
S
P
K
-
P
P
----
E
A
I
P
F
R
P
E
Y
A
N
R
L
L
G
T
S
Y
P
E
A
E
Q
I
A
I
L
K
R
L
G
C
R
-
V
E
G
E
G
-
P
T
Y
R
V
T
P
P
S
H
R
L
D
L
R
L
E
E
D
L
V
E
E
V
A
R
I
Q
G
Y
E
T
I
----
P
L
A
L
P
A
F
F
P
A
P
D
N
RG
V
----
E
A
P
-
Y
R
K
E
-------
Q
--
R
L
R
E
V
L
S
G
L
G
F
Q
E
V
Y
T
Y
S
F
M
D
P
E
D
A
R
R
F
R
L
D
-
P
P
R
L
L
-
L
L
N
P
L
A
P
E
K
A
A
L
R
T
H
L
F
P
G
L
V
R
V
L
K
E
N
L
D
L
D
R
P
E
R
A
L
L
F
E
V
G
R
V
F
------
R
E
R
------
E
E
--
T
H
------
L
A
G
L
L
F
G
E
GV
G
L
P
---
W
A
K
E
R
L
-
S
G
Y
F
L
L
K
G
Y
L
E
A
L
F
A
R
L
G
L
A
F
---
R
-
V
E
-
A
Q
A
F
-
P
F
L
H
P
G
V
S
G
R
V
L
V
E
G
E
E
V
G
F
L
G
A
L
H
P
E
I
A
Q
E
L
E
L
P
-
P
V
H
L
F
E
L
R
L
------
P
L
-
P
D
K
P
L
A
F
Q
D
P
S
----
R
H
P
A
A
F
R
D
L
A
V
V
V
P
A
P
T
P
Y
G
E
V
E
A
L
V
R
E
-
A
A
G
P
-
Y
L
E
S
L
A
L
F
D
L
Y
Q
G
P
P
L
P
E
G
H
K
S
L
A
F
H
L
R
F
R
H
P
K
R
T
L
R
D
E
E
V
E
E
A
V
S
R
V
A
E
A
L
R
A
R
G
F
G
L
R
G
L
D
24
HHSearch
83.81
29%
-90
- C1 -
2RHQ
-
SYFB_STAHJ
B:
[1-795]
M
L
I
S
N
E
W
L
K
D
Y
V
D
A
G
V
K
V
E
D
L
A
E
R
I
T
R
T
G
I
E
V
-
D
N
M
I
D
Y
S
K
D
-----
I
K
-
N
----
L
V
V
G
Y
I
Q
S
K
E
K
G
S
G
----
N
I
C
Q
V
D
-
I
G
E
E
E
-
P
V
Q
I
V
C
G
A
P
N
V
D
A
G
Q
H
V
I
V
A
K
V
G
G
R
L
P
G
G
-
I
K
I
K
R
A
K
L
R
G
E
R
S
E
G
M
I
C
S
L
Q
E
I
-----
G
I
S
S
N
VVPKA
Y
E
N
G
I
F
V
F
P
T
E
-
V
E
P
G
---
T
D
A
L
T
A
L
YL
N
----
D
Q
---
V
M
E
F
D
L
T
P
N
R
A
D
A
L
S
M
V
G
T
A
Y
E
V
A
A
L
Y
Q
T
E
M
T
--
K
P
--
E
T
Q
S
N
E
T
S
E
S
----------
A
T
N
E
L
S
V
T
I
D
N
P
E
K
V
P
Y
Y
S
A
R
V
V
K
N
V
S
-
I
-
E
P
-
S
P
I
W
V
Q
A
R
L
I
K
A
G
I
R
P
I
N
N
V
V
D
I
S
N
Y
V
L
L
E
Y
G
Q
P
L
H
M
F
D
Q
D
H
I
G
S
K
E
-
I
V
V
R
Q
A
K
D
E
E
T
M
T
T
L
-
D
N
N
E
R
K
L
V
D
T
D
I
V
I
S
----
N
G
Q
E
P
I
A
L
A
G
V
M
G
G
D
F
S
E
V
T
E
Q
T
T
N
V
V
I
E
G
A
I
F
D
P
V
S
I
R
H
T
S
R
R
L
N
L
R
S
E
A
S
S
R
F
E
K
G
I
A
T
E
F
V
D
E
A
V
D
R
A
C
Y
L
L
Q
E
L
A
S
G
E
V
-
L
Q
D
R
---
V
S
S
G
D
L
G
S
-
F
V
----
T
P
I
D
I
T
A
E
K
V
N
K
T
I
G
F
N
L
S
N
D
E
I
Q
S
I
F
R
Q
L
G
F
E
-
T
T
L
-
K
G
E
T
L
T
V
N
V
P
S
R
R
K
D
I
T
I
K
E
D
L
I
E
E
V
A
R
I
Y
G
Y
D
E
I
----
P
S
S
-----
L
P
V
F
G
E
V
T
S
G
E
L
T
D
R
-
Q
H
K
T
-------
R
--
T
L
K
E
T
L
E
G
A
G
L
N
Q
A
I
T
Y
S
L
V
S
K
D
H
A
K
D
F
A
L
Q
E
R
P
T
I
S
-
L
L
M
P
M
S
E
A
H
A
T
L
R
Q
S
L
L
P
H
L
I
E
A
T
A
Y
N
V
A
R
K
N
K
D
V
R
-
L
Y
E
I
G
R
V
F
------
F
G
N
GEGEL-
P
D
E
V
E
Y
------
L
S
G
I
L
T
G
E
--
Y
V
V
N
A
W
Q
G
K
K
E
E
-
I
D
F
F
I
A
K
G
V
V
D
R
V
A
E
K
L
N
L
---
E
F
S
-
Y
K
-
A
G
K
I
-
E
G
L
H
P
G
R
T
A
I
V
S
L
E
G
Q
D
I
G
F
I
G
E
L
H
P
Q
V
A
A
D
N
D
L
K
-
R
T
Y
V
F
E
L
N
Y
D
A
M
--
M
Q
V
A
V
-
G
Y
I
N
Y
E
Q
I
P
----
K
F
P
G
V
T
R
D
I
A
L
E
V
N
H
D
V
P
S
S
E
L
K
Q
I
I
H
N
-
N
G
-
E
D
I
L
Q
S
T
L
V
F
D
V
Y
E
-----
K
G
K
K
S
V
A
I
R
L
N
Y
L
D
T
E
D
T
L
T
D
E
R
V
S
K
I
H
D
K
I
L
E
A
L
Q
A
E
-
G
A
T
I
---
13
PsiBlast_PDB
83.63
27%
-89
- C1 -
1JJC
2
SYFB_THET8
B:
[1-779]
M
R
V
P
F
S
W
L
K
A
Y
V
P
E
L
E
S
P
E
V
L
E
E
R
L
A
G
L
G
F
E
T
-
D
R
I
E
R
-
V
F
P
-----
I
P
R
G
----
V
V
F
A
R
V
L
E
A
H
P
I
P
G
T
-
R
L
K
R
L
V
L
D
-
A
G
--
R
-
T
V
E
V
V
S
G
A
E
N
A
R
K
G
I
G
V
A
L
A
L
P
G
T
E
L
P
G
L
G
Q
K
V
G
E
R
V
I
Q
G
V
R
S
F
G
M
A
L
S
P
R
E
L
-----
G
V
G
-
E
-----
Y
G
G
G
L
L
E
F
P
E
D
A
L
P
P
G
---
T
P
L
S
E
----
A
----
W
P
E
E
V
V
L
D
L
E
V
T
P
N
R
P
D
A
L
G
L
L
G
L
A
R
D
L
H
A
L
G
Y
A
L
V
E
P
E
A
A
--
L
K
A
E
A
L
P
L
---------------
P
F
A
L
K
V
E
D
P
E
G
A
P
H
F
T
L
G
Y
A
F
G
L
R
-
V
-
A
P
-
S
P
L
W
M
Q
R
A
L
F
A
A
G
M
R
P
I
N
N
V
V
D
V
T
N
Y
V
M
L
E
R
A
Q
P
M
H
A
F
D
L
R
F
V
G
E
-
G
-
I
A
V
R
R
A
R
E
G
E
R
L
K
T
L
-
D
G
V
E
R
T
L
H
P
E
D
L
V
I
A
G
W
R
G
E
E
S
F
P
L
G
L
A
G
V
M
G
G
A
E
S
E
V
R
E
D
T
E
A
I
A
L
E
V
A
C
F
D
P
V
S
I
R
K
T
A
R
R
H
G
L
R
T
E
A
S
H
R
F
E
R
G
V
D
P
L
G
Q
V
P
A
Q
R
R
A
L
S
L
L
Q
A
L
A
G
A
R
V
-
A
E
A
L
---
L
E
A
G
-
S
P
K
-
P
P
----
E
A
I
P
F
R
P
E
Y
A
N
R
L
L
G
T
S
Y
P
E
A
E
Q
I
A
I
L
K
R
L
G
C
R
-
V
E
G
E
G
-
P
T
Y
R
V
T
P
P
S
H
R
L
D
L
R
L
E
E
D
L
V
E
E
V
A
R
I
Q
G
Y
E
T
I
----
P
L
A
L
P
A
F
F
P
A
P
D
N
RG
V
----
E
A
P
-
Y
R
K
E
-------
Q
--
R
L
R
E
V
L
S
G
L
G
F
Q
E
V
Y
T
Y
S
F
M
D
P
E
D
A
R
R
F
R
L
D
-
P
P
R
L
L
-
L
L
N
P
L
A
P
E
K
A
A
L
R
T
H
L
F
P
G
L
V
R
V
L
K
E
N
L
D
L
D
R
P
E
R
A
L
L
F
E
V
G
R
V
F
------
R
E
R
------
E
E
--
T
H
------
L
A
G
L
L
F
G
E
GV
G
L
P
---
W
A
K
E
R
L
-
S
G
Y
F
L
L
K
G
Y
L
E
A
L
F
A
R
L
G
L
A
F
---
R
-
V
E
-
A
Q
A
F
-
P
F
L
H
P
G
V
S
G
R
V
L
V
E
G
E
E
V
G
F
L
G
A
L
H
P
E
I
A
Q
E
L
E
L
P
-
P
V
H
L
F
E
L
R
L
------
P
L
-
P
D
K
P
L
A
F
Q
D
P
S
----
R
H
P
A
A
F
R
D
L
A
V
V
V
P
A
P
T
P
Y
G
E
V
E
A
L
V
R
E
-
A
A
G
P
-
Y
L
E
S
L
A
L
F
D
L
Y
Q
G
P
P
L
P
E
G
H
K
S
L
A
F
H
L
R
F
R
H
P
K
R
T
L
R
D
E
E
V
E
E
A
V
S
R
V
A
E
A
L
R
A
R
G
F
G
L
R
G
L
D
11
PsiBlast_PDB
83.56
27%
-89
- C1 -
1EIY
-
SYFB_THET8
B:
[1-779]
M
R
V
P
F
S
W
L
K
A
Y
V
P
E
L
E
S
P
E
V
L
E
E
R
L
A
G
L
G
F
E
T
-
D
R
I
E
R
-
V
F
P
-----
I
P
R
G
----
V
V
F
A
R
V
L
E
A
H
P
I
P
G
T
-
R
L
K
R
L
V
L
D
-
A
G
--
R
-
T
V
E
V
V
S
G
A
E
N
A
R
K
G
I
G
V
A
L
A
L
P
G
T
E
L
P
G
L
G
Q
K
V
G
E
R
V
I
Q
G
V
R
S
F
G
M
A
L
S
P
R
E
L
-----
G
V
G
-
E
-----
Y
G
G
G
L
L
E
F
P
E
D
A
L
P
P
G
---
T
P
L
S
E
----
A
----
W
P
E
E
V
V
L
D
L
E
V
T
P
N
R
P
D
A
L
G
L
L
G
L
A
R
D
L
H
A
L
G
Y
A
L
V
E
PE
A
A
--
L
K
A
E
A
L
P
L
---------------
P
F
A
L
K
V
E
D
P
E
G
A
P
H
F
T
L
G
Y
A
F
G
L
R
-
V
-
A
P
-
S
P
L
W
M
Q
R
A
L
F
A
A
G
M
R
P
I
N
N
V
V
D
V
T
N
Y
V
M
L
E
R
A
Q
P
M
H
A
F
D
L
R
F
V
G
E
-
G
-
I
A
V
R
R
A
R
E
G
E
R
L
K
T
L
-
D
G
V
E
R
T
L
H
P
E
D
L
V
I
A
G
W
R
G
E
E
S
F
P
L
G
L
A
G
V
M
G
G
A
E
S
E
V
R
E
D
T
E
A
I
A
L
E
V
A
C
F
D
P
V
S
I
R
K
T
A
R
R
H
G
L
R
T
E
A
S
H
R
F
E
R
G
V
D
P
L
G
Q
V
P
A
Q
R
R
A
L
S
L
L
Q
A
L
A
G
A
R
V
-
A
E
A
L
---
L
E
A
G
-
S
P
K
-
P
P
----
E
A
I
P
F
R
P
E
Y
A
N
R
L
L
G
T
S
Y
P
E
A
E
Q
I
A
I
L
K
R
L
G
C
R
-
V
E
G
E
G
-
P
T
Y
R
V
T
P
P
S
H
R
L
D
L
R
L
E
E
D
L
V
E
E
V
A
R
I
Q
G
Y
E
T
I
----
P
L
A
L
P
A
F
F
P
A
P
D
N
RG
V
----
E
A
P
-
Y
R
K
E
-------
Q
--
R
L
R
E
V
L
S
G
L
G
F
Q
E
V
Y
T
Y
S
F
M
D
P
E
D
A
R
R
F
R
L
D
-
P
P
R
L
L
-
L
L
N
P
L
A
P
E
K
A
A
L
R
T
H
L
F
P
G
L
V
R
V
L
K
E
N
L
D
L
D
R
P
E
R
A
L
L
F
E
V
G
R
V
F
------
R
E
R
------
E
E
--
T
H
------
L
A
G
L
L
F
G
E
GV
G
L
P
---
W
A
K
E
R
L
-
S
G
Y
F
L
L
K
G
Y
L
E
A
L
F
A
R
L
G
L
A
F
---
R
-
V
E
-
A
Q
A
F
-
P
F
L
H
P
G
V
S
G
R
V
L
V
E
G
E
E
V
G
F
L
G
A
L
H
P
E
I
A
Q
E
L
E
L
P
-
P
V
H
L
F
E
L
R
L
------
P
L
-
P
D
K
P
L
A
F
Q
D
P
S
----
R
H
P
A
A
F
R
D
L
A
V
V
V
P
A
P
T
P
Y
G
E
V
E
A
L
V
R
E
-
A
A
G
P
-
Y
L
E
S
L
A
L
F
D
L
Y
Q
G
P
P
L
P
E
G
H
K
S
L
A
F
H
L
R
F
R
H
P
K
R
T
L
R
D
E
E
V
E
E
A
V
S
R
V
A
E
A
L
R
A
R
G
F
G
L
R
G
L
D
16
PsiBlast_PDB
83.53
27%
-88
- C1 -
2AMC
3
SYFB_THETH
B:
[1-779]
M
R
V
P
F
S
W
L
K
A
Y
V
P
E
L
E
S
P
E
V
L
E
E
R
L
A
G
L
G
F
E
T
-
D
R
I
E
R
-
V
F
P
-----
I
P
R
G
----
V
V
F
A
R
V
L
E
A
H
P
I
P
G
T
-
R
L
K
R
L
V
L
D
-
A
G
--
R
-
T
V
E
V
V
S
G
A
E
N
A
R
K
G
I
G
V
A
L
A
L
P
G
T
E
L
P
G
L
G
Q
K
V
G
E
R
V
I
Q
G
V
R
S
F
G
M
A
L
S
P
R
E
L
-----
G
V
G
-
E
-----
Y
G
G
G
L
L
E
F
P
E
D
A
L
P
P
G
---
T
P
L
S
E
----
A
----
W
P
E
E
V
V
L
D
L
E
V
T
P
N
R
P
D
A
L
G
L
L
G
L
A
R
D
L
H
A
L
G
Y
A
L
V
E
PE
A
A
--
L
K
A
E
A
L
P
L
---------------
P
F
A
L
K
V
E
D
P
E
G
A
P
H
F
T
L
G
Y
A
F
G
L
R
-
V
-
A
P
-
S
P
L
W
M
Q
R
A
L
F
A
A
G
M
R
P
I
N
N
V
V
D
V
T
N
Y
V
M
L
E
R
A
Q
P
M
H
A
F
D
L
R
F
V
G
E
-
G
-
I
A
V
R
R
A
R
E
G
E
R
L
K
T
L
-
D
G
V
E
R
T
L
H
P
E
D
L
V
I
A
G
W
R
G
E
E
S
F
P
L
G
L
A
G
V
M
G
G
A
E
S
E
V
R
E
D
T
E
A
I
A
L
E
V
A
C
F
D
P
V
S
I
R
K
T
A
R
R
H
G
L
R
T
E
A
S
H
R
F
E
R
G
V
D
P
L
G
Q
V
P
A
Q
R
R
A
L
S
L
L
Q
A
L
A
G
A
R
V
-
A
E
A
L
---
L
E
A
G
-
S
P
K
-
P
P
----
E
A
I
P
F
R
P
E
Y
A
N
R
L
L
G
T
S
Y
P
E
A
E
Q
I
A
I
L
K
R
L
G
C
R
-
V
E
G
E
G
-
P
T
Y
R
V
T
P
P
S
H
R
L
D
L
R
L
E
E
D
L
V
E
E
V
A
R
I
Q
G
Y
E
T
I
----
P
L
A
L
P
A
F
F
P
A
P
D
N
RG
V
----
E
A
P
-
Y
R
K
E
-------
Q
--
R
L
R
E
V
L
S
G
L
G
F
Q
E
V
Y
T
Y
S
F
M
D
P
E
D
A
R
R
F
R
L
D
-
P
P
R
L
L
-
L
L
N
P
L
A
P
E
K
A
A
L
R
T
H
L
F
P
G
L
V
R
V
L
K
E
N
L
D
L
D
R
P
E
R
A
L
L
F
E
V
G
R
V
F
------
R
E
R
------
E
E
--
T
H
------
L
A
G
L
L
F
G
E
GV
G
L
P
---
W
A
K
E
R
L
-
S
G
Y
F
L
L
K
G
Y
L
E
A
L
F
A
R
L
G
L
A
F
---
R
-
V
E
-
A
Q
A
F
-
P
F
L
H
P
G
V
S
G
R
V
L
V
E
G
E
E
V
G
F
L
G
A
L
H
P
E
I
A
Q
E
L
E
L
P
-
P
V
H
L
F
E
L
R
L
------
P
L
-
P
D
K
P
L
A
F
Q
D
P
S
----
R
H
P
A
A
F
R
D
L
A
V
V
V
P
A
P
T
P
Y
G
E
V
E
A
L
V
R
E
-
A
A
G
P
-
Y
L
E
S
L
A
L
F
D
L
Y
Q
G
P
P
L
P
E
G
H
K
S
L
A
F
H
L
R
F
R
H
P
K
R
T
L
R
D
E
E
V
E
E
A
V
S
R
V
A
E
A
L
R
A
R
G
F
G
L
R
G
L
D
14
PsiBlast_PDB
83.41
27%
-88
- C1 -
2AKW
2
SYFB_THETH
B:
[1-779]
M
R
V
P
F
S
W
L
K
A
Y
V
P
E
L
E
S
P
E
V
L
E
E
R
L
A
G
L
G
F
E
T
-
D
R
I
E
R
-
V
F
P
-----
I
P
R
G
----
V
V
F
A
R
V
L
E
A
H
P
I
P
G
T
-
R
L
K
R
L
V
L
D
-
A
G
--
R
-
T
V
E
V
V
S
G
A
E
N
A
R
K
G
I
G
V
A
L
A
L
P
G
T
E
L
P
G
L
G
Q
K
V
G
E
R
V
I
Q
G
V
R
S
F
G
M
A
L
S
P
R
E
L
-----
G
V
G
-
E
-----
Y
G
G
G
L
L
E
F
P
E
D
A
L
P
P
G
---
T
P
L
S
E
----
A
----
W
P
E
E
V
V
L
D
L
E
V
T
P
N
R
P
D
A
L
G
L
L
G
L
A
R
D
L
H
A
L
G
Y
A
L
V
E
P
E
A
A
--
L
K
A
E
A
L
P
L
---------------
P
F
A
L
K
V
E
D
P
E
G
A
P
H
F
T
L
G
Y
A
F
G
L
R
-
V
-
A
P
-
S
P
L
W
M
Q
R
A
L
F
A
A
G
M
R
P
I
N
N
V
V
D
V
T
N
Y
V
M
L
E
R
A
Q
P
M
H
A
F
D
L
R
F
V
G
E
-
G
-
I
A
V
R
R
A
R
E
G
E
R
L
K
T
L
-
D
G
V
E
R
T
L
H
P
E
D
L
V
I
A
G
W
R
G
E
E
S
F
P
L
G
L
A
G
V
M
G
G
A
E
S
E
V
R
E
D
T
E
A
I
A
L
E
V
A
C
F
D
P
V
S
I
R
K
T
A
R
R
H
G
L
R
T
E
A
S
H
R
F
E
R
G
V
D
P
L
G
Q
V
P
A
Q
R
R
A
L
S
L
L
Q
A
L
A
G
A
R
V
-
A
E
A
L
---
L
E
A
G
-
S
P
K
-
P
P
----
E
A
I
P
F
R
P
E
Y
A
N
R
L
L
G
T
S
Y
P
E
A
E
Q
I
A
I
L
K
R
L
G
C
R
-
V
E
G
E
G
-
P
T
Y
R
V
T
P
P
S
H
R
L
D
L
R
L
E
E
D
L
V
E
E
V
A
R
I
Q
G
Y
E
T
I
----
P
L
A
L
P
A
F
F
P
A
P
D
N
RG
V
----
E
A
P
-
Y
R
K
E
-------
Q
--
R
L
R
E
V
L
S
G
L
G
F
Q
E
V
Y
T
Y
S
F
M
D
P
E
D
A
R
R
F
R
L
D
-
P
P
R
L
L
-
L
L
N
P
L
A
P
E
K
A
A
L
R
T
H
L
F
P
G
L
V
R
V
L
K
E
N
L
D
L
D
R
P
E
R
A
L
L
F
E
V
G
R
V
F
------
R
E
R
------
E
E
--
T
H
------
L
A
G
L
L
F
G
E
GV
G
L
P
---
W
A
K
E
R
L
-
S
G
Y
F
L
L
K
G
Y
L
E
A
L
F
A
R
L
G
L
A
F
---
R
-
V
E
-
A
Q
A
F
-
P
F
L
H
P
G
V
S
G
R
V
L
V
E
G
E
E
V
G
F
L
G
A
L
H
P
E
I
A
Q
E
L
E
L
P
-
P
V
H
L
F
E
L
R
L
------
P
L
-
P
D
K
P
L
A
F
Q
D
P
S
----
R
H
P
A
A
F
R
D
L
A
V
V
V
P
A
P
T
P
Y
G
E
V
E
A
L
V
R
E
-
A
A
G
P
-
Y
L
E
S
L
A
L
F
D
L
Y
Q
G
P
P
L
P
E
G
H
K
S
L
A
F
H
L
R
F
R
H
P
K
R
T
L
R
D
E
E
V
E
E
A
V
S
R
V
A
E
A
L
R
A
R
G
F
G
L
R
G
L
D
19
PsiBlast_PDB
83.38
27%
-88
- C1 -
4TVA
1
SYFB_THETH
B:
[1-779]
M
R
V
P
F
S
W
L
K
A
Y
V
P
E
L
E
S
P
E
V
L
E
E
R
L
A
G
L
G
F
E
T
-
D
R
I
E
R
-
V
F
P
-----
I
P
R
G
----
V
V
F
A
R
V
L
E
A
H
P
I
P
G
T
-
R
L
K
R
L
V
L
D
-
A
G
--
R
-
T
V
E
V
V
S
G
A
E
N
A
R
K
G
I
G
V
A
L
A
L
P
G
T
E
L
P
G
L
G
Q
K
V
G
E
R
V
I
Q
G
V
R
S
F
G
M
A
L
S
P
R
E
L
-----
G
V
G
-
E
-----
Y
G
G
G
L
L
E
F
P
E
D
A
L
P
P
G
---
T
P
L
S
E
----
A
----
W
P
E
E
V
V
L
D
L
E
V
T
P
N
R
P
D
A
L
G
L
L
G
L
A
R
D
L
H
A
L
G
Y
A
L
V
E
P
E
A
A
--
L
K
A
E
A
L
P
L
---------------
P
F
A
L
K
V
E
D
P
E
G
A
P
H
F
T
L
G
Y
A
F
G
L
R
-
V
-
A
P
-
S
P
L
W
M
Q
R
A
L
F
A
A
G
M
R
P
I
N
N
V
V
D
V
T
N
Y
V
M
L
E
R
A
Q
P
M
H
A
F
D
L
R
F
V
G
E
-
G
-
I
A
V
R
R
A
R
E
G
E
R
L
K
T
L
-
D
G
V
E
R
T
L
H
P
E
D
L
V
I
A
G
W
R
G
E
E
S
F
P
L
G
L
A
G
V
M
G
G
A
E
S
E
V
R
E
D
T
E
A
I
A
L
E
V
A
C
F
D
P
V
S
I
R
K
T
A
R
R
H
G
L
R
T
E
A
S
H
R
F
E
R
G
V
D
P
L
G
Q
V
P
A
Q
R
R
A
L
S
L
L
Q
A
L
A
G
A
R
V
-
A
E
A
L
---
L
E
A
G
-
S
P
K
-
P
P
----
E
A
I
P
F
R
P
E
Y
A
N
R
L
L
G
T
S
Y
P
E
A
E
Q
I
A
I
L
K
R
L
G
C
R
-
V
E
G
E
G
-
P
T
Y
R
V
T
P
P
S
H
R
L
D
L
R
L
E
E
D
L
V
E
E
V
A
R
I
Q
G
Y
E
T
I
----
P
L
A
L
P
A
F
F
P
A
P
D
N
RG
V
----
E
A
P
-
Y
R
K
E
-------
Q
--
R
L
R
E
V
L
S
G
L
G
F
Q
E
V
Y
T
Y
S
F
M
D
P
E
D
A
R
R
F
R
L
D
-
P
P
R
L
L
-
L
L
N
P
L
A
P
E
K
A
A
L
R
T
H
L
F
P
G
L
V
R
V
L
K
E
N
L
D
L
D
R
P
E
R
A
L
L
F
E
V
G
R
V
F
------
R
E
R
------
E
E
--
T
H
------
L
A
G
L
L
F
G
E
GV
G
L
P
---
W
A
K
E
R
L
-
S
G
Y
F
L
L
K
G
Y
L
E
A
L
F
A
R
L
G
L
A
F
---
R
-
V
E
-
A
Q
A
F
-
P
F
L
H
P
G
V
S
G
R
V
L
V
E
G
E
E
V
G
F
L
G
A
L
H
P
E
I
A
Q
E
L
E
L
P
-
P
V
H
L
F
E
L
R
L
------
P
L
-
P
D
K
P
L
A
F
Q
D
P
S
----
R
H
P
A
A
F
R
D
L
A
V
V
V
P
A
P
T
P
Y
G
E
V
E
A
L
V
R
E
-
A
A
G
P
-
Y
L
E
S
L
A
L
F
D
L
Y
Q
G
P
P
L
P
E
G
H
K
S
L
A
F
H
L
R
F
R
H
P
K
R
T
L
R
D
E
E
V
E
E
A
V
S
R
V
A
E
A
L
R
A
R
G
F
G
L
R
G
L
D
8
PsiBlast_PDB
83.34
30%
-91
- C1 -
2RHQ
-
SYFB_STAHJ
B:
[1-779]
M
L
I
S
N
E
W
L
K
D
Y
V
D
A
G
V
K
V
E
D
L
A
E
R
I
T
R
T
G
I
E
V
-
D
N
M
I
D
-
Y
S
K
DIKN
L
V
V
-
G
----
Y
I
Q
S
K
--------
E
K
G
S
G
N
I
C
Q
V
D
-
I
G
-
E
E
E
P
V
Q
I
V
C
G
A
P
N
V
D
A
G
Q
H
V
I
V
A
K
V
G
G
R
L
P
-
G
G
I
K
I
K
R
A
K
L
R
G
E
R
S
E
G
M
I
C
S
L
Q
E
I
GISSN
V
V
P
K
A
-----
Y
E
N
G
I
F
V
F
P
T
E
-
V
E
P
G
---
T
D
A
L
T
----
A
L
YLN
D
Q
---
V
M
E
F
D
L
T
P
N
R
A
D
A
L
S
M
V
G
T
A
Y
E
V
A
A
-------------
L
Y
Q
T
E
M
T
K
P
E
T
Q
S
N
E
T
S
E
S
A
-
T
N
E
L
S
V
T
I
D
N
P
E
K
V
P
Y
Y
S
A
R
V
V
K
N
V
S
-
I
-
E
P
-
S
P
I
W
V
Q
A
R
L
I
K
A
G
I
R
P
I
N
N
V
V
D
I
S
N
Y
V
L
L
E
Y
G
Q
P
L
H
M
F
D
Q
D
H
I
G
S
-
K
E
I
V
V
R
Q
A
K
D
E
E
T
M
T
T
L
D
N
N
E
R
K
L
V
D
T
D
I
-
V
I
S
----
N
G
Q
E
P
I
A
L
A
G
V
M
G
G
D
F
S
E
V
T
E
Q
T
T
N
V
V
I
E
G
A
I
F
D
P
V
S
I
R
H
T
S
R
R
L
N
L
R
S
E
A
S
S
R
F
E
K
G
I
A
T
E
F
V
D
E
A
V
D
R
A
C
Y
L
L
Q
E
L
A
S
G
E
V
L
Q
D
R
V
---
S
S
G
D
-
L
G
S
-
F
V
----
T
P
I
D
I
T
A
E
K
V
N
K
T
I
G
F
N
L
S
N
D
E
I
Q
S
I
F
R
Q
L
G
F
E
-
T
T
L
K
G
E
-
T
L
T
V
N
V
P
S
R
R
K
D
I
T
I
K
E
D
L
I
E
E
V
A
R
I
Y
G
Y
D
E
I
----
P
S
S
L
----
P
V
F
G
E
--
V
T
S
G
-
E
L
T
-
D
R
Q
H
-------
K
T
R
T
L
K
E
T
L
E
G
A
G
L
N
Q
A
I
T
Y
S
L
V
S
K
D
H
A
K
D
F
A
L
Q
-
E
R
P
T
I
S
L
L
M
P
M
S
E
A
H
A
T
L
R
Q
S
L
L
P
H
L
I
E
A
T
A
Y
N
V
A
R
K
N
K
D
V
R
-
L
Y
E
I
G
R
V
F
F
G
NGEG
E
L
P
------
D
E
V
E
Y
-------
L
S
G
I
L
T
G
E
--
Y
V
V
N
A
W
Q
G
K
K
E
E
-
I
D
F
F
I
A
K
G
V
V
D
R
V
A
E
K
L
N
L
E
F
---
S
-
Y
K
-
A
G
K
I
-
E
G
L
H
P
G
R
T
A
I
V
S
L
E
G
Q
D
I
G
F
I
G
E
L
H
P
Q
V
A
A
D
N
D
L
K
R
T
Y
V
-
F
E
L
N
Y
D
A
M
--
M
Q
V
-
A
V
G
---
Y
I
N
-
Y
E
Q
I
P
K
F
P
G
V
T
R
D
I
A
L
E
V
N
H
D
V
P
S
S
E
L
K
Q
I
I
H
N
-
N
G
-
E
D
I
L
Q
S
T
L
V
F
D
V
Y
E
-----
K
G
K
K
S
V
A
I
R
L
N
Y
L
D
T
E
D
T
L
T
D
E
R
V
S
K
I
H
D
K
I
L
E
A
L
Q
A
E
G
A
T
I
----
12
PsiBlast_PDB
83.13
27%
-88
- C1 -
1B70
1
SYFB_THETH
B:
[1-775]
M
R
V
P
F
S
W
L
K
A
Y
V
P
E
L
E
S
P
E
V
L
E
E
R
L
A
G
L
G
F
E
T
-
D
R
I
E
R
-
V
F
P
-----
I
P
R
G
----
V
V
F
A
R
V
L
E
A
H
P
I
P
G
T
-
R
L
K
R
L
V
L
D
-
A
G
--
R
-
T
V
E
V
V
S
G
A
E
N
A
R
K
G
I
G
V
A
L
A
L
P
G
T
E
L
P
G
L
G
Q
K
V
G
E
R
V
I
Q
G
V
R
S
F
G
M
A
L
S
P
R
E
L
-----
G
V
G
-
E
-----
Y
G
G
G
L
L
E
F
P
E
D
A
L
P
P
G
---
T
P
L
S
E
----
A
----
W
P
E
E
V
V
L
D
L
E
V
T
P
N
R
P
D
A
L
G
L
L
G
L
A
R
D
L
H
A
L
G
Y
A
L
V
E
P
E
A
A
--
L
K
A
E
A
L
P
L
---------------
P
F
A
L
K
V
E
D
P
E
G
A
P
H
F
T
L
G
Y
A
F
G
L
R
-
V
-
A
P
-
S
P
L
W
M
Q
R
A
L
F
A
A
G
M
R
P
I
N
N
V
V
D
V
T
N
Y
V
M
L
E
R
A
Q
P
M
H
A
F
D
L
R
F
V
G
E
-
G
-
I
A
V
R
R
A
R
E
G
E
R
L
K
T
L
-
D
G
V
E
R
T
L
H
P
E
D
L
V
I
A
G
W
R
G
E
E
S
F
P
L
G
L
A
G
V
M
G
G
A
E
S
E
V
R
E
D
T
E
A
I
A
L
E
V
A
C
F
D
P
V
S
I
R
K
T
A
R
R
H
G
L
R
T
E
A
S
H
R
F
E
R
G
V
D
P
L
G
Q
V
P
A
Q
R
R
A
L
S
L
L
Q
A
L
A
G
A
R
V
-
A
E
A
L
---
L
E
A
G
-
S
P
K
-
P
P
----
E
A
I
P
F
R
P
E
Y
A
N
R
L
L
G
T
S
Y
P
E
A
E
Q
I
A
I
L
K
R
L
G
C
R
-
V
E
G
E
G
-
P
T
Y
R
V
T
P
P
S
H
R
L
D
L
R
L
E
E
D
L
V
E
E
V
A
R
I
Q
G
Y
E
T
I
----
P
L
A
L
P
A
F
F
P
A
P
D
N
RG
V
----
E
A
P
-
Y
R
K
E
-------
Q
--
R
L
R
E
V
L
S
G
L
G
F
Q
E
V
Y
T
Y
S
F
M
D
P
E
D
A
R
R
F
R
L
D
-
P
P
R
L
L
-
L
L
N
P
L
A
P
E
K
A
A
L
R
T
H
L
F
P
G
L
V
R
V
L
K
E
N
L
D
L
D
R
P
E
R
A
L
L
F
E
V
G
R
V
F
------
R
E
R
------
E
E
--
T
H
------
L
A
G
L
L
F
G
E
GV
G
L
P
---
W
A
K
E
R
L
-
S
G
Y
F
L
L
K
G
Y
L
E
A
L
F
A
R
L
G
L
A
F
---
R
-
V
E
-
A
Q
A
F
-
P
F
L
H
P
G
V
S
G
R
V
L
V
E
G
E
E
V
G
F
L
G
A
L
H
P
E
I
A
Q
E
L
E
L
P
-
P
V
H
L
F
E
L
R
L
------
P
L
-
P
D
K
P
L
A
F
Q
D
P
S
----
R
H
P
A
A
F
R
D
L
A
V
V
V
P
A
P
T
P
Y
G
E
V
E
A
L
V
R
E
-
A
A
G
P
-
Y
L
E
S
L
A
L
F
D
L
Y
Q
G
P
P
L
P
E
G
H
K
S
L
A
F
H
L
R
F
R
H
P
K
R
T
L
R
D
E
E
V
E
E
A
V
S
R
V
A
E
A
L
R
A
R
--------