@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0464: (2015-12-01 )
MHDIEYIRQNSEEFEKAMESRGMKEFSAEEILKVDHKKRLLTTKLQDLNRQRNEITKKIKELKMSKSPCEKQIKSSKNITNEIEAISLKEQMEKDKLVNILSNLPNIPVQGVPIGAGENSNLEVRRYREKRQFDFVPKSHYELGERLGLMDFEQAAKISGSRFAILKGQLAKLGRALINFMLEMHVNEFGYTEVYHPVLVKNEAMYNVGQLPKFSDDSYLTTDELRLIPTGEVVLTNSVADKIVEEKKLPIRFTAYSECFRKEAGSAGQSTRGMIRQHQFGKVELVSITTEDQSNDELERMTGVAEEILKRLELPYRVILLCSGDMGFAAQKTYDIEVWLPEQNRYREISSCSNCGNFQARRMNAKYSLEANKKVKKYVHTLNGSALAIGRTIIAVMENYQNPDGSITIPNVLQKYISNGTVISK
Atome Classification :
(23 SA)
----------------........----.----10-.........20.--.--.--..--.-..30........40........50--.........60.-------....--------..-.------------------------70------------------------..---...-....80.--.......90.........100.......110......-.120....-------------.------.--..130--------------------......-----.140.......150...-.-...160.......170.......180.......190.......200.......210.......-220----------..---.-----.-----.....230.......240..--..--...250.......260.......270.......280..--.....--290.--.--.......300.......310.......320.......330.......340.......350.......360.......-370--.......--..380.......390.......400.......410.......420.....--------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------MH
D
I
E
Y
I
R----Q----
N
--
S
E
E
F
E
K
A
M
E
SRG--M--K--EF--
S
-
A
E
E
I
L
K
V
D
H
K
K
R
L
L
T
T
K
L
Q
D
L
N
R
---
Q
R
N
E
I
T
K
K
I
K
E
L-------KMSK--------S
P
-
C
------------------------
E
-------------------------
K
Q
---
I
K
S-SKNIT
N
E
--
I
E
A
I
S
L
K
E
-
Q
M
E
K
D
K
L
V
N
I
L
S
NLPNIPVQGVPIGAGE-NS-N
L
E
V
R
-------------
R
------
Y
--
R
E
K
RQ--------------------FDFV
P
K
-----
S
H
Y
E
L
G
E
RLGLM
D
F
E
Q
A
-
A
-KISG
S
R
F
A
I
L
K
G
Q
L
A
K
L
G
R
A
L
I
N
F
M
L
E
M
H
V
N
EFGYT
E
V
Y
H
P
V
L
VKN
E
A
MYNVGQLPKFSDDSY-L------------
T
T
---
D
-----
E
-----
L
R
L
IPTG
E
V
V
L
T
N
S
V
A
D
K
I
V
--
E
E--KKL
P
I
R
F
T
A
Y
S
E
C
F
R
K
EAGSAG
Q
S
T
R
G
M
I
R
QHQFG
K
V
E
--
L
V
S
I
T--T--E--D--QSN
D
E
L
E
R
M
T
G
V
A
E
E
I
L
K
RLEL
P
Y
R
V
I
L
L
CSGDMGFAA
Q
K
T
Y
D
I
E
V
W
LPEQN
R
Y
R
E
I
S
SCSNCGN
F
Q
ARRMN
A
K
Y
SL-E----A
N
K
K
V
K
K
--
Y
V
H
TLNG
S
A
L
A
I
G
R
T
I
I
A
V
M
E
NYQNPDG
S
I
T
I
P
N
V
L
Q
K
YISNG--TVISK--------------
1
PsiBlast_PDB
87.70
47%
-66
- C1 -
2DQ3
1
SYS_AQUAE
A:
[3-422]
------------------
D
I
N
L
I
R
----
E
----
K
--
P
D
Y
V
K
E
R
L
A
T
R
D
--
K
--
E
--
L
V
--
S
L
V
D
K
V
L
E
L
D
K
R
R
R
E
I
I
K
R
L
E
A
L
R
S
---
E
R
N
K
L
S
K
E
I
G
K
L
-------
K
R
E
G
--------
K
D
-
T
------------------------
T
-------------------------
E
I
---
Q
N
R
-
V
K
E
L
K
E
E
--
I
D
R
L
E
E
E
L
-
R
K
V
E
E
E
L
K
N
T
L
L
W
I
P
N
L
P
H
P
S
V
P
V
G
E
D
E
-
K
D
-
N
V
E
V
R
-------------
R
------
W
--
G
E
P
R
K
--------------------
F
D
F
E
P
K
-----
P
H
W
E
I
G
E
R
L
G
I
L
D
F
K
R
G
-
A
-
K
L
S
G
S
R
F
T
V
I
A
G
W
G
A
R
L
E
R
A
L
I
N
F
M
L
D
L
H
T
K
K
-
G
Y
K
E
I
C
P
P
H
L
V
K
P
E
I
L
I
G
T
G
Q
L
P
K
F
E
E
D
L
Y
K
C
------------
E
R
---
D
-----
N
-----
L
Y
L
I
P
T
A
E
V
P
L
T
N
L
Y
R
E
E
I
L
--
K
E
--
E
N
L
P
I
Y
L
T
A
Y
T
P
C
Y
R
R
E
A
G
A
Y
G
K
D
I
R
G
I
I
R
Q
H
Q
F
D
K
V
E
--
L
V
K
I
V
--
H
--
P
--
D
--
T
S
Y
D
E
L
E
K
L
V
K
D
A
E
E
V
L
Q
L
L
G
L
P
Y
R
V
V
E
L
C
T
G
D
L
G
F
S
A
A
K
T
Y
D
I
E
V
W
F
P
S
Q
N
K
Y
R
E
I
S
S
C
S
N
C
E
D
F
Q
A
R
R
M
N
T
R
F
K
D
-
S
----
K
T
G
K
-
N
R
--
F
V
H
T
L
N
G
S
G
L
A
V
G
R
T
L
A
A
I
L
E
N
Y
Q
Q
E
D
G
S
V
V
V
P
E
V
L
R
D
Y
V
G
T
D
--
V
I
R
P
E
--------------
27
HHSearch
87.44
47%
-67
- C1 -
2DQ3
1
SYS_AQUAE
A:
[1-423]
----------------
M
I
D
I
N
L
I
R
----
E
----
K
--
P
D
Y
V
K
E
R
L
A
T
R
D
--
K
--
E
L-
V
S
--
L
-
V
D
K
V
L
E
L
D
K
R
R
R
E
I
I
K
R
L
E
A
L
R
S
---
E
R
N
K
L
S
K
E
I
G
K
L
-------
K
R
E
G
--------
K
D
-
T
------------------------
T
-------------------------
E
I
---
Q
N
R
-
V
K
E
L
K
E
E
--
I
D
R
L
E
E
E
L
-
R
K
V
E
E
E
L
K
N
T
L
L
W
I
P
N
L
P
H
P
S
V
P
V
G
E
D
E
-
K
D
-
N
V
E
V
R
-------------
R
------
W
--
G
E
P
R
K
--------------------
F
D
F
E
P
K
-----
P
H
W
E
I
G
E
R
L
G
I
L
D
F
K
R
G
-
A
-
K
L
S
G
S
R
F
T
V
I
A
G
W
G
A
R
L
E
R
A
L
I
N
F
M
L
D
L
H
T
-
K
K
G
Y
K
E
I
C
P
P
H
L
V
K
P
E
I
L
I
G
T
G
Q
L
P
K
F
E
E
D
L
Y
-
K
------------
C
E
---
R
D----
N
-----
L
Y
L
I
P
T
A
E
V
P
L
T
N
L
Y
R
E
E
I
L
--
K
E
--
E
N
L
P
I
Y
L
T
A
Y
T
P
C
Y
R
R
E
A
G
A
Y
G
K
D
I
R
G
I
I
R
Q
H
Q
F
D
K
V
E
--
L
V
K
I
V
--
H
--
P
--
D
--
T
S
Y
D
E
L
E
K
L
V
K
D
A
E
E
V
L
Q
L
L
G
L
P
Y
R
V
V
E
L
C
T
G
D
L
G
F
S
A
A
K
T
Y
D
I
E
V
W
F
P
S
Q
N
K
Y
R
E
I
S
S
C
S
N
C
E
D
F
Q
A
R
R
M
N
T
R
F
K
D
-
S
----
K
-
T
G
K
N
R
--
F
V
H
T
L
N
G
S
G
L
A
V
G
R
T
L
A
A
I
L
E
N
Y
Q
Q
E
D
G
S
V
V
V
P
E
V
L
R
D
Y
V
G
T
D
--
V
I
R
P
E
--------------
30
HHSearch
83.93
38%
-65
- C1 -
2DQ0
5
SYS_PYRHO
A:
[1-445]
----------------
M
L
D
I
K
L
I
R
----
E
----
N
--
P
E
L
V
K
N
D
L
I
K
R
G
--
E
--
L
EK
V
K
--
W
-
V
D
E
I
L
K
L
D
T
E
W
R
T
K
L
K
E
I
N
R
L
R
H
---
E
R
N
K
I
A
V
E
I
G
K
R
-------
R
K
K
G
--------
E
P
-
V
------------------------
D
-------------------------
E
L
---
L
A
K
-
S
R
E
I
V
K
R
--
I
G
E
L
E
N
E
V
-
E
E
L
K
K
K
I
D
Y
Y
L
W
R
L
P
N
I
T
H
P
S
V
P
V
G
K
D
E
-
N
D
-
N
V
P
I
R
-------------
F
------
W
--
G
K
A
R
V
WKGH
L
E
R
F
L
E
Q
S
QGK
M
E
Y
E
I
L
E
W
K
P
K
-----
L
H
V
D
L
L
E
I
L
G
G
A
D
F
A
R
A
-
A
-
K
V
S
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
L
I
-
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
E
D
F
E
D
V
I
Y
-
K
------------
V
E
---
D
E----
D
-----
L
Y
L
I
P
T
A
E
H
P
L
A
G
M
H
A
N
E
I
L
--
D
G
--
K
D
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
--
Q
F
V
Y
S
--
R
--
P
--
E
--
E
S
W
E
W
H
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
F
R
D
-
R
----
T
-
D
E
K
P
R
--
Y
V
H
T
L
N
S
T
A
I
A
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
T
G
F
K
--
E
I
V
P
V
--------------
3
PsiBlast_PDB
83.10
38%
-65
- C1 -
2ZR2
5
SYS_PYRHO
A:
[1-437]
----------------
M
L
D
I
K
L
I
R
----
E
----
N
--
P
E
L
V
K
N
D
L
I
K
R
G
--
E
--
L
--
E
K
V
K
W
-
V
D
E
I
L
K
L
D
T
E
W
R
---
T
K
L
K
E
I
N
R
L
R
H
E
R
N
K
I
A
V
E
I
G
K
R
-------
R
K
K
G
--------
E
P
-
V
------------------------
D
-------------------------
E
L
---
L
A
K
-
S
R
E
I
V
K
R
--
I
G
E
L
E
N
E
V
-
E
E
L
K
K
K
I
D
Y
Y
L
W
R
L
P
N
I
T
H
P
S
V
P
V
G
K
D
E
-
N
D
-
N
V
P
I
R
F
W
G
K
A
R
V
W
KGH
L
E
R
------
F
--
L
E
Q
S
Q
GK
M
E
Y
E
I
-------------
L
E
W
K
P
K
-----
L
H
V
D
L
L
E
I
L
G
G
A
D
F
A
R
A
-
A
-
K
V
S
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
L
I
-
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
E
D
F
E
D
V
I
Y
-
K
------------
V
E
---
D
-----
E
D----
L
Y
L
I
P
T
A
E
H
P
L
A
G
M
H
A
N
E
I
L
--
D
G
--
K
D
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
--
Q
F
V
Y
S
--
R
--
P
--
E
--
E
S
W
E
W
H
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
F
R
D
-
R
----
T
D
E
K
-
P
R
--
Y
V
H
T
L
N
S
T
A
I
A
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
T
G
F
K
--
E
I
V
P
V
--------------
2
PsiBlast_PDB
83.07
38%
-65
- C1 -
2DQ0
5
SYS_PYRHO
A:
[1-437]
----------------
M
L
D
I
K
L
I
R
----
E
----
N
--
P
E
L
V
K
N
D
L
I
K
R
G
--
E
--
L
--
E
K
V
K
W
-
V
D
E
I
L
K
L
D
T
E
W
R
---
T
K
L
K
E
I
N
R
L
R
H
E
R
N
K
I
A
V
E
I
G
K
R
-------
R
K
K
G
--------
E
P
-
V
------------------------
D
-------------------------
E
L
---
L
A
K
-
S
R
E
I
V
K
R
--
I
G
E
L
E
N
E
V
-
E
E
L
K
K
K
I
D
Y
Y
L
W
R
L
P
N
I
T
H
P
S
V
P
V
G
K
D
E
-
N
D
-
N
V
P
I
R
F
W
G
KARVWKGH
L
E
R
------
F
--
L
E
Q
S
Q
GK
M
E
Y
E
I
-------------
L
E
W
K
P
K
-----
L
H
V
D
L
L
E
I
L
G
G
A
D
F
A
R
A
-
A
-
K
V
S
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
L
I
-
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
E
D
F
E
D
V
I
Y
-
K
------------
V
E
---
D
-----
E
D----
L
Y
L
I
P
T
A
E
H
P
L
A
G
M
H
A
N
E
I
L
--
D
G
--
K
D
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
--
Q
F
V
Y
S
--
R
--
P
--
E
--
E
S
W
E
W
H
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
F
R
D
-
R
----
T
D
E
K
-
P
R
--
Y
V
H
T
L
N
S
T
A
I
A
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
T
G
F
K
--
E
I
V
P
V
--------------
4
PsiBlast_PDB
82.77
38%
-61
- C1 -
2ZR3
-
SYS_PYRHO
A:
[1-437]
----------------
M
L
D
I
K
L
I
R
----
E
----
N
--
P
E
L
V
K
N
D
L
I
K
R
G
--
E
--
L
--
E
K
V
K
W
-
V
D
E
I
L
K
L
D
T
E
W
R
---
T
K
L
K
E
I
N
R
L
R
H
E
R
N
K
I
A
V
E
I
G
K
R
-------
R
K
K
G
--------
E
P
-
V
------------------------
D
-------------------------
E
L
---
L
A
K
-
S
R
E
I
V
K
R
--
I
G
E
L
E
N
E
V
-
E
E
L
K
K
K
I
D
Y
Y
L
W
R
L
P
N
I
T
H
P
S
V
P
V
G
K
D
E
-
N
D
-
N
V
P
I
R
F
W
G
KARVWKGH
L
E
R
------
F
--
L
E
Q
S
Q
GK
M
E
Y
E
I
-------------
L
E
W
K
P
K
-----
L
H
V
D
L
L
E
I
L
G
G
A
D
F
A
R
A
-
A
-
K
V
S
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
L
I
-
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
E
D
F
E
D
V
I
Y
-
K
------------
V
E
---
D
-----
E
D----
L
Y
L
I
P
T
A
E
H
P
L
A
G
M
H
A
N
E
I
L
--
D
G
--
K
D
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
--
Q
F
V
Y
S
--
R
--
P
--
E
--
E
S
W
E
W
H
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
F
R
D
-
R
----
T
D
E
K
-
P
R
--
Y
V
H
T
L
N
S
T
A
I
A
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
T
G
F
K
--
E
I
V
P
V
--------------
21
PsiBlast_CBE
82.52
38%
-64
- C1 -
2ZR2
4
SYS_PYRHO
B:
[1-437]
----------------
M
L
D
I
K
L
I
R
----
E
----
N
--
P
E
L
V
K
N
D
L
I
K
R
G
--
E
--
L
--
E
K
VK
W
-
V
D
E
I
L
K
L
D
T
E
W
R
---
T
K
L
K
E
I
N
R
LRH
E
R
N
K
I
A
V
E
I
G
K
R
-------
R
K
K
G
--------
E
P
-
V
------------------------
D
-------------------------
E
L
---
L
A
K
-
S
R
E
I
V
K
R
--
I
G
E
L
E
N
E
V
-
E
E
L
K
K
K
I
D
Y
Y
L
W
R
L
P
N
I
T
H
P
S
V
P
V
G
K
D
E
-
N
D
-
N
V
P
I
R
FWGKARVWKGHLE
R
------
F
--
L
E
Q
S
Q
GKMEYEI-------------
L
E
W
K
P
K
-----
L
H
V
D
L
L
E
I
L
G
G
A
D
F
A
R
A
-
A
-
K
V
S
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
L
I
-
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
E
D
F
E
D
V
I
Y
-
K
------------
V
E
---
D
-----
E
D----
L
Y
L
I
P
T
A
E
H
P
L
A
G
M
H
A
N
E
I
L
--
D
G
--
K
D
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
--
Q
F
V
Y
S
--
R
--
P
--
E
--
E
S
W
E
W
H
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
F
R
D
-
R
----
T
D
E
K
-
P
R
--
Y
V
H
T
L
N
S
T
A
I
A
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
T
G
F
K
--
E
I
V
P
V
--------------
22
PsiBlast_CBE
81.64
38%
-66
- C1 -
2DQ0
4
SYS_PYRHO
B:
[1-437]
----------------
M
L
D
I
K
L
I
R
----
E
----
N
--
P
E
L
V
K
N
D
L
I
K
R
G
--
E
--
L
--
E
K
VK
W
-
V
D
E
I
L
K
L
D
T
E
W
R
---
T
K
L
K
E
I
N
R
LRH
E
R
N
K
I
A
V
E
I
G
K
R
-------
R
K
K
G
--------
E
P
-
V
------------------------
D
-------------------------
E
L
---
L
A
K
-
S
R
E
I
V
K
R
--
I
G
E
L
E
N
E
V
-
E
E
L
K
K
K
I
D
Y
Y
L
W
R
L
P
N
I
T
H
P
S
V
P
V
G
K
D
E
-
N
D
-
N
V
P
I
R
FWGKARVWKGHLE
R
------
F
--
L
E
Q
S
Q
GKMEYEI-------------
L
E
W
K
P
K
-----
L
H
V
D
L
L
E
I
L
G
G
A
D
F
A
R
A
-
A
-
K
V
S
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
L
I
-
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
E
D
F
E
D
V
I
Y
-
K
------------
V
E
---
D
-----
E
D----
L
Y
L
I
P
T
A
E
H
P
L
A
G
M
H
A
N
E
I
L
--
D
G
--
K
D
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
--
Q
F
V
Y
S
--
R
--
P
--
E
--
E
S
W
E
W
H
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
F
R
D
-
R
----
T
D
E
K
-
P
R
--
Y
V
H
T
L
N
S
T
A
I
A
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
T
G
F
K
--
E
I
V
P
V
--------------
32
HHSearch
78.28
33%
-62
- C1 -
3QNE
-
SYSC_CANAL
A:
[1-438]
----------------
M
L
D
I
N
A
F
L
VEKG
G
----
D
--
P
E
I
I
K
A
S
Q
K
K
R
G
--
D
--
S
--
V
E
--
L
-
V
D
E
I
I
A
E
Y
K
E
W
V
K
L
R
F
D
L
D
E
H
N
K
---
K
L
N
S
V
Q
K
E
I
G
K
R
-------
F
K
A
K
--------
E
D
-
A
------------------------
K
-------------------------
D
L
---
I
A
E
-
K
E
K
L
S
N
E
--
K
K
E
I
I
E
K
E
-
A
E
A
D
K
N
L
R
S
K
I
N
Q
V
G
N
I
V
H
E
S
V
V
D
S
Q
D
E
-
E
N
-
N
E
L
V
R
-------------
T
------
W
--
T
P
E
N
Y
KKPEQIAAAT----------
G
A
P
A
K
L
-----
S
H
H
E
V
L
L
R
L
D
G
Y
D
P
E
R
G
-
V
-
R
I
V
G
H
R
G
Y
F
L
R
N
Y
G
V
F
L
N
Q
A
L
I
N
Y
G
L
S
F
L
S
-
S
K
G
Y
V
P
L
Q
A
P
V
M
M
N
K
E
V
M
A
K
T
A
Q
L
S
Q
F
D
E
E
L
Y
-
K
------------
V
I
---
D
GE
D
--
E
-----
K
Y
L
I
A
T
S
E
Q
P
I
S
A
Y
H
A
G
E
W
F
ES
P
A
--
E
Q
L
P
V
R
Y
A
G
Y
S
S
C
F
R
R
E
A
G
-----
A
W
G
I
F
R
V
H
A
F
E
K
I
E
--
Q
F
V
L
T
--
E
--
P
--
E
--
K
S
W
E
E
F
D
R
M
I
G
C
S
E
E
F
Y
Q
S
L
G
L
P
Y
R
V
V
G
I
V
S
G
E
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
F
Q
Q
E
Y
K
E
L
V
S
C
S
N
C
T
D
Y
Q
S
R
N
L
E
I
R
C
G
I
----------
E
K
K
--
Y
V
H
C
L
N
S
T
L
S
A
T
E
R
T
I
C
C
I
L
E
N
Y
Q
K
E
D
G
-
L
V
I
P
E
V
L
R
K
Y
I
P
G
E
--
P
E
F
I
P
--------------
28
HHSearch
77.90
32%
-63
- C1 -
3LSS
4
?
A:
[7-468]
----------------
V
L
D
I
Q
L
F
R
----
D
----
E
T
G
A
N
I
I
R
E
S
Q
R
R
R
F
--
A
--
D
--
P
D
--
I
-
V
D
A
I
I
E
A
D
K
K
W
R
R
T
Q
F
L
T
E
A
S
K
K
---
L
I
N
I
C
S
K
A
V
G
A
K
-------
K
K
A
K
--------
E
A
C
V
------------------------
L
-------------------------
Q
L
---
K
Q
L
-
S
K
D
L
S
D
Q
--
V
A
G
L
A
K
E
A
-
Q
Q
L
E
E
E
R
D
K
L
M
L
N
V
G
N
I
L
H
E
S
V
P
I
A
Q
D
E
E
T
G
-
N
T
V
V
R
-------------
T
------
F
--
G
N
T
T
K
----------------------
R
A
K
L
-----
N
H
V
S
I
M
E
R
L
G
M
M
D
T
S
K
A
-
V
T
S
M
A
G
G
R
S
Y
V
L
K
G
G
L
V
Q
L
Q
V
A
L
V
S
Y
S
L
D
F
L
V
-
K
R
G
Y
T
P
F
Y
P
P
F
F
L
N
R
D
V
M
G
E
V
A
Q
L
S
Q
F
D
E
E
L
Y
-
Q
------------
V
S
---
G
D
G
D
--
K
-----
K
Y
L
I
A
T
S
E
M
P
I
A
A
Y
H
R
G
R
W
F
--
T
E
--
L
K
E
P
L
K
Y
A
G
M
S
T
C
F
R
K
E
A
G
A
H
G
R
D
T
L
G
I
F
R
V
H
Q
F
D
K
I
E
--
Q
F
V
V
C
--
S
--
P
--
R
QE
E
S
W
R
H
L
E
D
M
I
T
T
S
E
E
F
N
K
S
L
G
L
P
Y
R
V
V
N
I
C
S
G
A
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
A
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
S
Q
S
V
N
C
R
Y
G
P
-
N
----
L
R
Q
N
V
K
E
--
Y
C
H
M
L
N
G
T
L
C
A
I
T
R
T
M
C
C
I
C
E
N
Y
Q
T
E
E
G
-
V
V
I
P
D
V
L
R
P
Y
M
M
G
I
--
E
M
I
R
F
--------------
29
HHSearch
77.45
33%
-61
- C1 -
1SES
1
SYS_THET2
A:
[1-418]
----------------
M
V
D
L
K
R
L
R
----
Q
----
E
--
P
E
V
F
H
R
A
I
R
E
K
G
--
V
--
A
--
L
D
----
L
E
A
L
L
A
L
D
R
E
V
Q
E
L
K
K
R
L
Q
E
V
Q
T
---
E
R
N
Q
V
A
K
R
V
P
K
A
-------
P
P
----------
E
E
-
K
------------------------
E
-------------------------
A
L
---
I
A
R
-
G
K
A
L
G
E
E
--
A
K
R
L
E
E
A
L
-
R
E
K
E
A
R
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
G
E
E
--
A
-
N
R
E
I
K
-------------
R
------
V
--
G
G
P
P
E
--------------------
F
S
F
P
P
L
-----
D
H
V
A
L
M
E
K
N
G
W
W
E
-
P
R
I
-
S
-
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
-
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
D
Q
V
W
-
A
------------
I
A
---
E
T----
D
-----
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
--
P
Y
--
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
--
Q
Y
V
L
T
--
E
--
A
S
L
E
--
A
S
D
R
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
Y
R
D
-
P
------
E
G
R
V
R
--
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
K
E
--
V
L
E
P
C
--------------
15
PsiBlast_PDB
76.50
30%
-71
- C1 -
3VBB
2
SYSC_HUMAN
A:
[34-463]
---------------------------------------------------------------
D
Q
L
V
K
A
D
S
E
W
R
R
C
R
F
R
A
D
N
L
N
K
---
L
K
N
L
C
S
K
T
I
G
E
K
-------
M
K
K
K
--------
E
----------------------------DESVPENVLSFDDLT
A
D
A
L
A
N
L
KV-
S
Q
---
I
K
K
-
V
R
L
L
I
D
E
A
I
L
K
C
D
A
E
R
I
-
K
L
E
A
E
R
F
E
N
-
L
R
E
I
G
N
L
L
H
P
S
V
P
I
S
N
D
E
-
D
V
-
D
N
K
V
E
-------------
R
IWGDCT
V
--
R
K
K
Y
--------------------------------
S
H
V
D
L
V
V
M
V
D
G
F
E
G
E
K
G
-
A
-
V
V
A
G
S
R
G
Y
F
L
K
G
V
L
V
F
L
E
Q
A
L
I
Q
Y
A
L
R
T
-
L
G
S
R
G
Y
I
P
I
Y
T
P
F
F
M
R
K
E
V
M
Q
E
V
A
Q
L
S
-
F
D
E
E
L
Y
-
K
VI---------------
D
-----
E
-----
K
Y
L
I
A
T
S
E
Q
P
I
A
A
L
H
R
D
E
W
L
--
R
P
--
E
D
L
P
I
K
Y
A
G
L
S
T
C
F
R
Q
E
V
G
S
----
T
R
G
I
F
R
V
H
Q
F
E
K
I
E
Q
F
V
Y
S
S
P
--
H
--
D
--
N
--
K
S
W
E
M
F
E
E
M
I
T
T
A
E
E
F
Y
Q
S
L
G
I
P
Y
H
I
V
N
I
V
S
G
S
L
N
H
A
A
S
K
K
L
D
L
E
A
W
F
P
G
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
A
R
R
L
R
I
R
Y
G
--
Q
----
T
---
M
D
K
V
E
F
V
H
M
L
N
A
T
M
C
A
T
T
R
T
I
C
A
I
L
E
N
Y
Q
T
E
K
G
-
I
T
V
P
E
K
L
K
E
F
M
P
P
G
--
L
Q
E
L
I
--------------
31
HHSearch
76.44
31%
-67
- C1 -
3VBB
2
SYSC_HUMAN
A:
[2-468]
----------------
V
L
D
L
D
L
F
R
----
V
DKGG
D
--
P
A
L
I
R
E
T
Q
E
K
R
F
--
K
--
D
--
P
G
--
L
-
V
D
Q
L
V
K
A
D
S
E
W
R
R
C
R
F
R
A
D
N
L
N
K
---
L
K
N
L
C
S
K
T
I
G
E
K
-------
M
K
K
K
--------
E
---DESVPENVLSFDDLT
A
D
A
L
A
N
L
KV
S
-------------------------
Q
I
---
K
K
V
-
R
L
L
I
D
E
A
--
I
L
K
C
D
A
E
R
-
I
K
L
E
A
E
R
F
E
N
L
R
E
I
G
N
L
L
H
P
S
V
P
I
S
N
D
E
D
V
D
-
N
K
V
E
R
-------------
I
------
W
--
G
D
C
T
V
----------------------
R
K
K
Y
-----
S
H
V
D
L
V
V
M
V
D
G
F
E
G
E
K
G
-
A
-
V
V
A
G
S
R
G
Y
F
L
K
G
V
L
V
F
L
E
Q
A
L
I
Q
Y
A
L
R
T
L
G
-
S
R
G
Y
I
P
I
Y
T
P
F
F
M
R
K
E
V
M
Q
E
V
A
Q
L
S
-
F
D
E
E
L
Y
-
K
------------
V
I
----D----
E
-----
K
Y
L
I
A
T
S
E
Q
P
I
A
A
L
H
R
D
E
W
L
--
R
P
--
E
D
L
P
I
K
Y
A
G
L
S
T
C
F
R
Q
E
V
G
S
----
T
R
G
I
F
R
V
H
Q
F
E
K
I
E
--
Q
F
V
Y
S
--
S
--
P
--
H
DN
K
S
W
E
M
F
E
E
M
I
T
T
A
E
E
F
Y
Q
S
L
G
I
P
Y
H
I
V
N
I
V
S
G
S
L
N
H
A
A
S
K
K
L
D
L
E
A
W
F
P
G
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
A
R
R
L
R
I
R
Y
G
Q
-
T
------
M
D
K
V
E
--
F
V
H
M
L
N
A
T
M
C
A
T
T
R
T
I
C
A
I
L
E
N
Y
Q
T
E
K
G
-
I
T
V
P
E
K
L
K
E
F
M
P
P
G
LQ
E
L
I
P
F
--------------
11
PsiBlast_PDB
76.33
34%
-69
- C1 -
3QNE
-
SYSC_CANAL
A:
[45-435]
---------------------------------------------------------------------------
L
R
F
D
L
D
E
H
N
K
---
K
L
N
S
V
Q
K
E
I
G
K
R
-------
F
K
A
K
--------
E
D
-
A
------------------------
K
-------------------------
D
L
---
I
A
E
-
K
E
K
L
S
N
E
--
K
K
E
I
I
E
K
E
-
A
E
A
D
K
N
L
R
S
K
I
N
Q
V
G
N
I
V
H
E
S
V
V
D
S
Q
D
E
-
E
N
-
N
E
L
V
R
T
W
T
PE--------
N
------
Y
--
K
K
P
E
Q
--------------------
I
A
A
A
T
G
APAKL
S
H
H
E
V
L
L
R
L
D
G
Y
D
P
E
R
G
-
V
-
R
I
V
G
H
R
G
Y
F
L
R
N
Y
G
V
F
L
N
Q
A
L
I
N
Y
G
L
S
F
-
L
S
S
K
G
Y
V
P
L
Q
A
P
V
M
M
N
K
E
V
M
A
K
T
A
Q
L
S
Q
F
D
E
E
L
Y
-
K
------------
V
I
---
D
GE
D
--
E
-----
K
Y
L
I
A
T
S
E
Q
P
I
S
A
Y
H
A
G
E
W
F
--
E
S
PA
E
Q
L
P
V
R
Y
A
G
Y
S
S
C
F
R
R
E
A
G
-----
A
W
G
I
F
R
V
H
A
F
E
K
I
E
--
Q
F
V
L
T
--
E
--
P
--
E
--
K
S
W
E
E
F
D
R
M
I
G
C
S
E
E
F
Y
Q
S
L
G
L
P
Y
R
V
V
G
I
V
S
G
E
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
F
Q
Q
E
Y
K
E
L
V
S
C
S
N
C
T
D
Y
Q
S
R
N
L
E
I
R
C
G
I
----------
E
K
K
--
Y
V
H
C
L
N
S
T
L
S
A
T
E
R
T
I
C
C
I
L
E
N
Y
Q
K
E
D
G
-
L
V
I
P
E
V
L
R
K
Y
I
P
G
E
--
P
E
F
I
P
--------------
13
PsiBlast_PDB
76.10
34%
-70
- C1 -
3QO8
4
SYSC_CANAL
A:
[45-435]
---------------------------------------------------------------------------
L
R
F
D
L
D
E
H
N
K
---
K
L
N
S
V
Q
K
E
I
G
K
R
-------
F
K
-----------
D
-
A
------------------------
K
-------------------------
D
L
---
I
A
E
-
K
E
K
L
S
N
E
--
K
K
E
I
I
E
K
E
-
A
E
A
D
K
N
L
R
S
K
I
N
Q
V
G
N
I
V
H
E
S
V
V
D
S
Q
D
E
-
E
N
-
N
E
L
V
R
T
W
T
P
E
--------
N
------
Y
--
K
K
P
E
Q
--------------------
I
A
A
A
T
G
APAKL
S
H
H
E
V
L
L
R
L
D
G
Y
D
P
E
R
G
-
V
-
R
I
V
G
H
R
G
Y
F
L
R
N
Y
G
V
F
L
N
Q
A
L
I
N
Y
G
L
S
F
-
L
S
S
K
G
Y
V
P
L
Q
A
P
V
M
M
N
K
E
V
M
A
K
T
A
Q
L
S
Q
F
D
E
E
L
Y
-
K
------------
V
I
---
D
GE
D
--
E
-----
K
Y
L
I
A
T
S
E
Q
P
I
S
A
Y
H
A
G
E
W
F
--
E
S
PA
E
Q
L
P
V
R
Y
A
G
Y
S
S
C
F
R
R
E
A
G
S
H
G
K
D
A
W
G
I
F
R
V
H
A
F
E
K
I
E
--
Q
F
V
L
T
--
E
--
P
--
E
--
K
S
W
E
E
F
D
R
M
I
G
C
S
E
E
F
Y
Q
S
L
G
L
P
Y
R
V
V
G
I
V
S
G
E
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
F
Q
Q
E
Y
K
E
L
V
S
C
S
N
C
T
D
Y
Q
S
R
N
L
E
I
R
C
G
I
K-----------
K
--
Y
V
H
C
L
N
S
T
L
S
A
T
E
R
T
I
C
C
I
L
E
N
Y
Q
K
E
D
G
-
L
V
I
P
E
V
L
R
K
Y
I
P
G
E
--
P
E
F
I
P
--------------
12
PsiBlast_PDB
76.06
34%
-68
- C1 -
3QO7
1
SYSC_CANAL
A:
[45-435]
---------------------------------------------------------------------------
L
R
F
D
L
D
E
H
N
K
---
K
L
N
S
V
Q
K
E
I
G
K
R
-------
F
K
A
K
--------
E
D
-
A
------------------------
K
-------------------------
D
L
---
I
A
E
-
K
E
K
L
S
N
E
--
K
K
E
I
I
E
K
E
-
A
E
A
D
K
N
L
R
S
K
I
N
Q
V
G
N
I
V
H
E
S
V
V
D
S
Q
D
E
-
E
N
-
N
E
L
V
R
T
W
T
P
E--------
N
------
Y
--
K
K
P
E
Q
--------------------
I
A
A
A
T
G
APAKL
S
H
H
E
V
L
L
R
L
D
G
Y
D
P
E
R
G
-
V
-
R
I
V
G
H
R
G
Y
F
L
R
N
Y
G
V
F
L
N
Q
A
L
I
N
Y
G
L
S
F
-
L
S
S
K
G
Y
V
P
L
Q
A
P
V
M
M
N
K
E
V
M
A
K
T
A
Q
L
S
Q
F
D
E
E
L
Y
-
K
------------
V
I
---
D
GE
D
--
E
-----
K
Y
L
I
A
T
S
E
Q
P
I
S
A
Y
H
A
G
E
W
F
--
E
S
PA
E
Q
L
P
V
R
Y
A
G
Y
S
S
C
F
R
R
E
A
G
-----
A
W
G
I
F
R
V
H
A
F
E
K
I
E
--
Q
F
V
L
T
--
E
--
P
--
E
--
K
S
W
E
E
F
D
R
M
I
G
C
S
E
E
F
Y
Q
S
L
G
L
P
Y
R
V
V
G
I
V
S
G
E
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
F
Q
Q
E
Y
K
E
L
V
S
C
S
N
C
T
D
Y
Q
S
R
N
L
E
I
R
C
G
I
----------
E
K
K
--
Y
V
H
C
L
N
S
T
L
S
A
T
E
R
T
I
C
C
I
L
E
N
Y
Q
K
E
D
G
-
L
V
I
P
E
V
L
R
K
Y
I
P
G
E
--
P
E
F
I
P
--------------
48
Fugue
75.69
28%
-61
- C1 -
1WLE
1
SYSM_BOVIN
A:
[24-490]
RN
L
L
Y
E
H
A
R
E
GYSALP
L
L
D
M
E
S
L
C
----
A
----
Y
--
P
E
D
A
A
R
A
L
D
L
R
K
--
G
EL
R
--
S
K
--
D
-
L
P
G
I
I
S
T
W
Q
E
L
R
Q
L
R
E
Q
I
R
S
L
E
E
---
E
K
E
A
V
T
E
A
V
R
A
L
-------
V
V
N
Q
DNSQVQQD
P
Q
-
Y
------------------------
Q
-------------------------
S
L
---
R
A
R
-
G
R
E
I
R
K
Q
--
L
T
L
L
Y
P
K
E
-
A
Q
L
E
E
Q
F
Y
L
R
A
L
R
L
P
N
Q
T
H
P
D
V
P
V
G
-
D
E
-
S
Q
-
A
R
V
L
H
-------------
V
------
V
--
G
D
K
P
A
--------------------
F
S
F
Q
P
R
-----
G
H
L
E
I
A
E
K
L
D
I
I
R
Q
K
R
L
-
S
-
H
V
S
G
H
R
S
Y
Y
L
R
G
A
G
A
L
L
Q
H
G
L
V
N
F
T
L
N
K
L
I
H
R
-
G
F
T
P
M
T
V
P
D
L
L
R
G
V
V
F
E
G
C
G
M
T
P
N
A
K
P
S
Q
I
-
Y
------------
N
I
---
D
-----
P
SRFED
L
N
L
A
G
T
A
E
V
G
L
A
G
Y
F
M
D
H
S
V
--
A
F
--
R
D
L
P
I
R
M
V
C
S
S
T
C
Y
R
A
E
T
D
T
---
G
P
W
G
L
Y
R
V
H
H
F
T
K
V
E
--
M
F
G
V
T
--
G
PG
L
--
E
--
Q
S
S
E
L
L
E
E
F
L
S
L
Q
M
E
I
L
T
E
L
G
L
H
F
R
V
L
D
M
P
T
Q
E
L
G
L
P
A
Y
R
K
F
D
I
E
A
W
M
P
G
R
G
R
F
G
E
V
T
S
A
S
N
C
T
D
F
Q
S
R
R
L
H
I
M
F
Q
T
-
E
----
A
G
E
--
L
Q
--
F
A
H
T
V
N
A
T
G
C
A
V
P
R
L
L
I
A
L
L
E
S
Y
Q
Q
K
D
G
S
V
L
V
P
P
A
L
Q
P
Y
L
G
T
D
--
R
I
T
T
P
THVPLQYIGPNQPQ
17
PsiBlast_PDB
75.49
27%
-63
- C1 -
1WLE
1
SYSM_BOVIN
A:
[42-475]
------------------
D
M
E
S
L
C
----
A
----
Y
--
P
E
D
A
A
R
A
L
D
L
R
K
GE
L
--
R
--
S
K
--
D
-
L
P
G
I
I
S
T
W
Q
E
L
R
Q
L
R
E
Q
I
R
S
L
E
E
---
E
K
E
A
V
T
E
A
V
R
A
L
V
V
N
Q
DNS
Q
V
Q
Q
--------
D
P
-
Q
------------------------
Y
-------------------------
Q
S
---
L
R
A
R
G
R
E
I
R
K
Q
--
L
T
L
L
Y
P
K
E
A
Q
L
E
E
Q
F
Y
L
R
A
L
-
R
L
P
N
Q
T
H
P
D
V
P
V
G
-
D
E
-
S
Q
-
A
R
V
L
H
-------------
V
------
V
--
G
D
K
P
A
--------------------
F
S
F
Q
P
R
-----
G
H
L
E
I
A
E
K
L
D
I
I
R
Q
K
R
L
-
S
-
H
V
S
G
H
R
S
Y
Y
L
R
G
A
G
A
L
L
Q
H
G
L
V
N
F
T
L
N
K
L
I
H
R
-
G
F
T
P
M
T
V
P
D
L
L
R
G
V
V
F
E
G
C
G
M
T
P
N
A
K
P
S
Q
I
-
Y
------------
N
I
---
D
PSRFE
D
-----
L
N
L
A
G
T
A
E
V
G
L
A
G
Y
F
M
D
H
S
V
--
A
F
--
R
D
L
P
I
R
M
V
C
S
S
T
C
Y
R
A
E
T
D
T
-
G
--
P
W
G
L
Y
R
V
H
H
F
T
K
V
E
--
M
F
G
V
T
--
G
--
P
G
L
E
--
Q
S
S
E
L
L
E
E
F
L
S
L
Q
M
E
I
L
T
E
L
G
L
H
F
R
V
L
D
M
P
T
Q
E
L
G
L
P
A
Y
R
K
F
D
I
E
A
W
M
P
G
R
G
R
F
G
E
V
T
S
A
S
N
C
T
D
F
Q
S
R
R
L
H
I
M
F
Q
T
-
E
----
A
G
E
--
L
Q
--
F
A
H
T
V
N
A
T
G
C
A
V
P
R
L
L
I
A
L
L
E
S
Y
Q
Q
K
D
G
S
V
L
V
P
P
A
L
Q
P
Y
L
G
T
D
--
R
I
T
T
P
--------------
10
PsiBlast_PDB
75.10
34%
-70
- C1 -
3QO5
-
SYSC_CANAL
A:
[45-435]
---------------------------------------------------------------------------
L
R
F
D
L
D
E
H
N
K
---
K
L
N
S
V
Q
K
E
I
G
K
R
-------
F
-----------------------------------------------------------------
D
L
---
I
A
E
-
K
E
K
L
S
N
E
--
K
K
E
I
I
E
K
E
-
A
E
A
D
K
N
L
R
S
K
I
N
Q
V
G
N
I
V
H
E
S
V
V
D
S
Q
D
E
-
E
N
-
N
E
L
V
R
T
W
T
P
E--------
N
------
Y
--
K
K
P
E
Q
--------------------
I
A
A
A
T
G
APAKL
S
H
H
E
V
L
L
R
L
D
G
Y
D
P
E
R
G
-
V
-
R
I
V
G
H
R
G
Y
F
L
R
N
Y
G
V
F
L
N
Q
A
L
I
N
Y
G
L
-
L
F
L
S
S
K
G
Y
V
P
L
Q
A
P
V
M
M
N
K
E
V
M
A
K
T
A
Q
L
S
Q
F
D
E
E
L
Y
-
K
------------
V
I
---
D
GE
D
--
E
-----
K
Y
L
I
A
T
S
E
Q
P
I
S
A
Y
H
A
G
E
W
F
--
E
S
PA
E
Q
L
P
V
R
Y
A
G
Y
S
S
C
F
R
R
E
A
G
-----
A
W
G
I
F
R
V
H
A
F
E
K
I
E
--
Q
F
V
L
T
--
E
--
P
--
E
--
K
S
W
E
E
F
D
R
M
I
G
C
S
E
E
F
Y
Q
S
L
G
L
P
Y
R
V
V
G
I
V
S
G
E
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
F
Q
Q
E
Y
K
E
L
V
S
C
S
N
C
T
D
Y
Q
S
R
N
L
E
I
R
C
G
I
----------
E
K
K
--
Y
V
H
C
L
N
S
T
L
S
A
T
E
R
T
I
C
C
I
L
E
N
Y
Q
K
E
D
G
-
L
V
I
P
E
V
L
R
K
Y
I
P
G
E
--
P
E
F
I
P
--------------
16
PsiBlast_PDB
74.47
30%
-67
- C1 -
4L87
4
SYSC_HUMAN
A:
[32-462]
--------------------------------------------------------------
V
D
Q
L
V
K
A
D
S
E
W
R
R
C
R
F
R
A
D
N
L
N
K
---
L
K
N
L
C
S
K
T
I
G
E
K
-------
M
K
K
K
--------
E
P
-
V
------------------------
G
DDESVPENVLSFDDLT
A
D
A
L
A
N
LK
V
S
Q
---
I
K
K
-
V
R
L
L
I
D
E
A
I
L
K
C
D
A
E
R
I
-
K
L
E
A
E
R
F
E
N
-
L
R
E
I
G
N
L
L
H
P
S
V
P
I
S
N
D
E
-
D
V
-
D
N
K
V
E
-------------
R
IWGDCT
V
--
R
K
K
Y
--------------------------------
S
H
V
D
L
V
V
M
V
D
G
F
E
G
E
K
G
-
A
-
V
V
A
G
S
R
G
Y
F
L
K
G
V
L
V
F
L
E
Q
A
L
I
Q
Y
A
L
R
T
-
L
G
S
R
G
Y
I
P
I
Y
T
P
F
F
M
R
K
E
V
M
Q
E
V
A
Q
L
S
Q
F
D
E
E
L
Y
-
K
V
I
G
KGSEKSDDN
S
Y
---
D
-----
E
-----
K
Y
L
I
A
T
S
E
Q
P
I
A
A
L
H
R
D
E
W
L
--
R
P
--
E
D
L
P
I
K
Y
A
G
L
S
T
C
F
R
Q
E
V
G
S
H
G
R
D
T
R
G
I
F
R
V
H
Q
F
E
K
I
E
Q
F
V
Y
S
S
P
--
H
--
D
--
N
--
K
S
W
E
M
F
E
E
M
I
T
T
A
E
E
F
Y
Q
S
L
G
I
P
Y
H
I
V
N
I
V
S
G
S
L
N
H
A
A
S
K
K
L
D
L
E
A
W
F
P
G
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
A
R
R
L
R
I
R
Y
G
--
Q
----
T
K
K
M
M
D
K
V
E
F
V
H
M
L
N
A
T
M
C
A
T
T
R
T
I
C
A
I
L
E
N
Y
Q
T
E
K
G
-
I
T
V
P
E
K
L
K
E
F
M
P
P
G
--
L
Q
E
L
I
--------------
23
PsiBlast_CBE
73.03
32%
-58
- C1 -
1SET
1
SYS_THET2
B:
[1-413]
----------------
M
V
D
L
K
R
L
R
----
Q
----
E
--
P
E
V
F
H
R
A
I
R
E
K
G
--
V
--
A
--
L
D
--
L
-
E
A
L
L
A
L
D
R
E
V
Q
E
L
-
K
K
R
L
Q
E
V
Q
T
---
E
R
N
Q
V
A
K
R
V
------------
P
K
--------
A
P
-
P
------------------------
E
-------------------------
E
K
EAL
I
A
R
-
G
K
A
L
G
E
E
--
A
K
R
L
E
E
A
L
-
R
E
K
E
A
R
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
-
G
E
-
E
A
-
N
R
E
I
K
-------------
R
------
V
--
G
G
P
P
E
--------------------
F
S
F
P
P
L
-----
D
H
V
A
L
M
E
K
N
G
W
W
E
-
P
R
I
-
S
-
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
-
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
D
Q
V
W
-
A
------------
I
A
---
E
T----
D
-----
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
--
P
Y
--
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
--
Q
Y
V
L
T
EA
S
--
L
--
E
--
A
S
D
R
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
Y
R
--
D
----
P
E
G
R
V
-
R
--
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
K
E
--
V
L
E
P
C
--------------
33
HHSearch
67.67
35%
-68
- C1 -
3ERR
1
DYHC1_MOUSE (first)
A:
[178-525]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
---
L
K
R
-
V
E
P
L
R
N
E
--
L
Q
K
L
E
D
D
A
-
K
D
N
Q
Q
K
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
G
E
E
--
A
-
N
R
E
I
K
-------------
R
------
V
--
G
G
P
P
E
--------------------
F
S
F
P
P
L
-----
D
H
V
A
L
M
E
K
N
G
W
W
E
P
-
R
I
-
S
-
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
-
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
D
Q
V
W
-
A
------------
I
A
---
E
T----
D
-----
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
--
P
Y
--
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
--
Q
Y
V
L
T
--
E
--
A
S
L
E
--
A
S
D
R
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
Y
R
D
-
P
----
E
--
G
R
V
R
--
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
K
E
--
V
L
E
P
G
--------------
25
PsiBlast_CBE
66.78
35%
-67
- C1 -
3LSS
2
?
B:
[105-461]
--------------------------------------------------------------------------------------------------------------------------
C
------------------------
V
-------------------------
L
Q
---
L
K
Q
L
S
K
D
L
S
D
Q
--
V
A
G
L
A
K
E
A
-
Q
Q
L
E
E
E
R
D
K
L
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L
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V
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N
I
L
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E
S
V
P
I
A
Q
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-
E
T
G
N
T
V
V
R
-------------
T
------
F
GN
T
T
K
R
------------------------
A
K
L
-----
N
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V
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I
M
E
R
L
G
M
M
D
T
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T
-
S
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F
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M
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E
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A
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L
S
Q
F
D
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E
L
Y
-
Q
------------
V
S
GDG
D
-----
K
-----
K
Y
L
I
A
T
S
E
M
P
I
A
A
Y
H
R
G
R
W
F
--
T
E
--
L
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E
P
L
K
Y
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A
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A
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S
N
C
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D
Y
Q
S
Q
S
V
N
C
R
Y
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P
-
N
L
R
GT
A
A
Q
N
V
K
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--
Y
C
H
M
L
N
G
T
L
C
A
I
T
R
T
M
C
C
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C
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Y
Q
T
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-
V
V
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V
L
R
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Y
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M
G
I
--
E
M
I
R
F
--------------