@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0493: (2015-12-02 )
MKEKSLLVKAGRKFEDYKGSMNPPVYHSSTILFPTYKDYLDAADGKNIYGVVNDGIARDYSYGSVGTPTVHYFSNALAEIEGRGQALIYPSGLFALTFAILTFARAGSHVLIQDNSYYRLRRFAENELPKRRVEVTFYDPTQDIASLIQSNTRLIMIETPGSVTFEVSNIEHIVKIAKEHKIVTVCDNSWATPLLFRPLDYGIDVALYGVTKYIAGHSDLLMGAIIAEGEVFKLLYEICKNYGVTVQPYDCYLAHRGLRTLGTRMRKHQSTAMKVAKWLEKHSKIKKVLYPALPSHPQHELWKSYFKGASGVFSIVLDREYSCEELSCMVDHMKIFSIGASWGGCDSLILPIDRKSVSRSVMSSDYSGSFIRIFCGLEDPEDLISDLNAALARLPCLGFQADEVGHDTKRITA
Atome Classification :
(20 SA)
......---...10....--.-...20........30........40........50........60........70........80........90........100.......110.......120.......130.......140--.--.......-150.......160.......170.......--180-........190.......200.......210.......220-......-.230...--...--.--.240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......-350-.......--.360---.------.----.----.------....370.......380.......390.......400.......410.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKE
K
S
L
---
L
V
K
AGRK
F
E
--D-YKGSMNPPVYHS
S
T
I
L
FP
T
Y
K
D
Y
LDAADG
K
N
I
Y
G
V
VNDGIARDYSYGSVGT
P
T
V
H
Y
F
S
N
A
L
A
E
IEGRG
Q
A
L
I
YPS
G
L
F
A
L
T
F
A
I
L
T
F
ARAG
S
H
V
L
IQDN
S
Y
Y
R
L
R
R
F
A
ENELPK
R
R
V
E
V
T
F
YDP-
T
--
Q
--
D
I
A
S
L
I
Q-SN
T
R
L
I
M
I
ETPG
S
V
T
F
E
VS
N
I
E
H
I
V
K
I
A
K
E--H-
K
-
I
V
T
VCDNSWATP
L
L
FRPLDYGI
D
V
A
L
Y
G
V
T
K
Y
IAGH
S
D
L
L
M
-
G
A
I
IAE-
G
E
-
V
F
K
L
--
L
Y
E
--
I
--
C
K
NYG
V
T
VQ
P
Y
D
C
Y
L
A
HR
G
L
R
T
L
G
T
R
M
R
K
H
Q
S
T
A
M
K
V
A
K
W
L
E
K
H
S
K
I
K
K
V
LYPALPSHP
Q
H
E
L
W
K
S
Y
FKGAS
G
V
F
S
I
V
LDREY
S
C
E
E
L
S
C
M
V
D
H
M
K
I
F
S
IGASWGGCD
S
L
I
-
L
P--I
D
R
K
S
V
S
--
R
S
V
----
M
------S----S----D------YSG
S
F
I
R
I
F
CGLE
D
P
E
D
L
I
S
D
L
N
A
A
L
A
RLPCLGFQ
A
D
EVGHDTKRITA
25
PsiBlast_CBE
96.31
35%
-119
- C1 -
2FQ6
1
METC_ECOLI
B:
[24-414]
---
K
K
L
D
T
Q
L
V
N
A
G
R
S
K
K
--
Y
-
T
L
G
A
V
N
S
V
I
Q
R
A
S
S
L
V
F
-------
D
S
V
E
A
K
K
-
H
A
T
R
N
R
A
N
G
E
L
F
-
Y
G
R
R
G
T
L
T
H
F
S
L
Q
Q
A
M
C
E
L
E
G
G
A
G
C
V
L
F
P
C
G
A
A
A
V
A
N
S
I
L
A
F
I
E
Q
G
D
H
V
L
M
T
N
T
A
Y
E
P
S
Q
D
F
C
S
K
I
L
S
K
L
G
V
T
T
S
W
F
D
P
-
L
IG
A
--
D
I
V
K
H
L
Q
-
P
N
T
K
I
V
F
L
E
S
P
G
S
I
T
M
E
V
H
D
V
P
A
I
V
A
A
V
R
S
V
V
P
-
D
-
A
I
I
M
I
D
N
T
W
A
A
G
V
L
F
K
A
L
D
F
G
I
D
V
S
I
Q
A
A
T
K
Y
L
V
G
H
S
D
A
M
I
-
G
T
A
V
C
N
-
A
R
-
C
W
E
Q
--
L
R
E
--
N
--
A
Y
L
M
G
Q
M
V
D
A
D
T
A
Y
I
T
S
R
G
L
R
T
L
G
V
R
L
R
Q
H
H
E
S
S
L
K
V
A
E
W
L
A
E
H
P
Q
V
A
R
V
N
H
P
A
L
P
G
S
K
G
H
E
F
W
K
R
D
F
T
G
S
S
G
L
F
S
F
V
L
K
K
K
L
N
N
E
E
L
A
N
Y
L
D
N
F
S
L
F
S
M
A
Y
S
W
G
G
Y
E
S
L
I
-
L
A
--
N
Q
P
E
H
I
A
A
I
R
P
Q
----
G
------
E
----
I
----
D
------
F
S
G
T
L
I
R
L
H
I
G
L
E
D
V
D
D
L
I
A
D
L
D
A
G
F
A
R
I
V
------------------
23
PsiBlast_CBE
95.80
35%
-119
- C1 -
1CL2
1
METC_ECOLI
B:
[4-394]
---
K
K
L
D
T
Q
L
V
N
A
G
R
S
K
K
--
Y
-
T
L
G
A
V
N
S
V
I
Q
R
A
S
S
L
V
F
-------
D
S
V
E
A
K
K
-
H
A
T
R
N
R
A
N
G
E
L
F
-
Y
G
R
R
G
T
L
T
H
F
S
L
Q
Q
A
M
C
E
L
E
G
G
A
G
C
V
L
F
P
C
G
A
A
A
V
A
N
S
I
L
A
F
I
E
Q
G
D
H
V
L
M
T
N
T
A
Y
E
P
S
Q
D
F
C
S
K
I
L
S
K
L
G
V
T
T
S
W
F
D
P
-
L
IG
A
--
D
I
V
K
H
L
Q
-
P
N
T
K
I
V
F
L
E
S
P
G
S
I
T
M
E
V
H
D
V
P
A
I
V
A
A
V
R
S
V
V
P
-
D
-
A
I
I
M
I
D
N
T
W
A
A
G
V
L
F
K
A
L
D
F
G
I
D
V
S
I
Q
A
A
T
K
Y
L
V
G
H
S
D
A
M
I
-
G
T
A
V
C
N
-
A
R
-
C
W
E
Q
--
L
R
E
--
N
--
A
Y
L
M
G
Q
M
V
D
A
D
T
A
Y
I
T
S
R
G
L
R
T
L
G
V
R
L
R
Q
H
H
E
S
S
L
K
V
A
E
W
L
A
E
H
P
Q
V
A
R
V
N
H
P
A
L
P
G
S
K
G
H
E
F
W
K
R
D
F
T
G
S
S
G
L
F
S
F
V
L
K
K
K
L
N
N
E
E
L
A
N
Y
L
D
N
F
S
L
F
S
M
A
Y
S
W
G
G
Y
E
S
L
I
-
L
A
--
N
Q
P
E
H
I
A
A
I
R
P
Q
----
G
------
E
----
I
----
D
------
F
S
G
T
L
I
R
L
H
I
G
L
E
D
V
D
D
L
I
A
D
L
D
A
G
F
A
R
I
V
------------------
24
PsiBlast_CBE
95.76
35%
-120
- C1 -
2GQN
1
METC_ECOLI
B:
[24-414]
---
K
K
L
D
T
Q
L
V
N
A
G
R
S
K
K
--
Y
-
T
L
G
A
V
N
S
V
I
Q
R
A
S
S
L
V
F
-------
D
S
V
E
A
K
K
-
H
A
T
R
N
R
A
N
G
E
L
F
-
Y
G
R
R
G
T
L
T
H
F
S
L
Q
Q
A
M
C
E
L
E
G
G
A
G
C
V
L
F
P
C
G
A
A
A
V
A
N
S
I
L
A
F
I
E
Q
G
D
H
V
L
M
T
N
T
A
Y
E
P
S
Q
D
F
C
S
K
I
L
S
K
L
G
V
T
T
S
W
F
D
P
-
L
IG
A
--
D
I
V
K
H
L
Q
-
P
N
T
K
I
V
F
L
E
S
P
G
S
I
T
M
E
V
H
D
V
P
A
I
V
A
A
V
R
S
V
V
P
-
D
-
A
I
I
M
I
D
N
T
W
A
A
G
V
L
F
K
A
L
D
F
G
I
D
V
S
I
Q
A
A
T
K
Y
L
V
G
H
S
D
A
M
I
-
G
T
A
V
C
N
-
A
R
-
C
W
E
Q
--
L
R
E
--
N
--
A
Y
L
M
G
Q
M
V
D
A
D
T
A
Y
I
T
S
R
G
L
R
T
L
G
V
R
L
R
Q
H
H
E
S
S
L
K
V
A
E
W
L
A
E
H
P
Q
V
A
R
V
N
H
P
A
L
P
G
S
K
G
H
E
F
W
K
R
D
F
T
G
S
S
G
L
F
S
F
V
L
K
K
K
L
N
N
E
E
L
A
N
Y
L
D
N
F
S
L
F
S
M
A
Y
S
W
G
G
Y
E
S
L
I
-
L
A
--
N
Q
P
E
H
I
A
A
I
R
P
Q
----
G
------
E
----
I
----
D
------
F
S
G
T
L
I
R
L
H
I
G
L
E
D
V
D
D
L
I
A
D
L
D
A
G
F
A
R
I
V
------------------
3
PsiBlast_PDB
95.69
35%
-118
- C1 -
2GQN
1
METC_ECOLI
A:
[25-414]
----
K
L
D
T
Q
L
V
N
A
G
R
S
K
K
--
Y
-
T
L
G
A
V
N
S
V
I
Q
R
A
S
S
L
V
F
-------
D
S
V
E
A
K
K
-
H
A
T
R
N
R
A
N
G
E
L
F
-
Y
G
R
R
G
T
L
T
H
F
S
L
Q
Q
A
M
C
E
L
E
G
G
A
G
C
V
L
F
P
C
G
A
A
A
V
A
N
S
I
L
A
F
I
E
Q
G
D
H
V
L
M
T
N
T
A
Y
E
P
S
Q
D
F
C
S
K
I
L
S
K
L
G
V
T
T
S
W
F
D
P
-
L
IG
A
--
D
I
V
K
H
L
Q
-
P
N
T
K
I
V
F
L
E
S
P
G
S
I
T
M
E
V
H
D
V
P
A
I
V
A
A
V
R
S
V
V
P
-
D
-
A
I
I
M
I
D
N
T
W
A
A
G
V
L
F
K
A
L
D
F
G
I
D
V
S
I
Q
A
A
T
K
Y
L
V
G
H
S
D
A
M
I
-
G
T
A
V
C
N
-
A
R
-
C
W
E
Q
--
L
R
E
--
N
--
A
Y
L
M
G
Q
M
V
D
A
D
T
A
Y
I
T
S
R
G
L
R
T
L
G
V
R
L
R
Q
H
H
E
S
S
L
K
V
A
E
W
L
A
E
H
P
Q
V
A
R
V
N
H
P
A
L
P
G
S
K
G
H
E
F
W
K
R
D
F
T
G
S
S
G
L
F
S
F
V
L
K
K
K
L
N
N
E
E
L
A
N
Y
L
D
N
F
S
L
F
S
M
A
Y
S
W
G
G
Y
E
S
L
I
-
L
A
--
N
Q
P
E
H
I
A
A
I
R
P
Q
----
G
------
E
----
I
----
D
------
F
S
G
T
L
I
R
L
H
I
G
L
E
D
V
D
D
L
I
A
D
L
D
A
G
F
A
R
I
V
------------------
27
PsiBlast_CBE
95.47
35%
-118
- C1 -
4ITG
1
METC_ECOLI
A:
[5-394]
----
K
L
D
T
Q
L
V
N
A
G
R
S
K
K
--
Y
-
T
L
G
A
V
N
S
V
I
Q
R
A
S
S
L
V
F
-------
D
S
V
E
A
K
K
-
H
A
T
R
N
R
A
N
G
E
L
F
-
Y
G
R
R
G
T
L
T
H
F
S
L
Q
Q
A
M
C
E
L
E
G
G
A
G
C
V
L
F
P
C
G
A
A
A
V
A
N
S
I
L
A
F
I
E
Q
G
D
H
V
L
M
T
N
T
A
Y
E
S
S
Q
D
F
C
S
K
I
L
S
K
L
G
V
T
T
S
W
F
D
P
-
L
IG
A
--
D
I
V
K
H
L
Q
-
P
N
T
K
I
V
F
L
E
S
P
G
S
I
T
M
E
V
H
D
V
P
A
I
V
A
A
V
R
S
VV
P
-
D
-
A
I
I
M
I
D
N
T
W
A
A
G
V
L
F
K
A
L
D
F
G
I
D
V
S
I
Q
A
A
T
K
Y
L
V
G
H
S
D
A
M
I
-
G
T
A
V
C
N
-
A
R
-
C
W
E
Q
--
L
R
E
--
N
--
A
Y
L
M
G
Q
M
V
D
A
D
T
A
Y
I
T
S
R
G
L
R
T
L
G
V
R
L
R
Q
H
H
E
S
S
L
K
V
A
E
W
L
A
E
H
P
Q
V
A
R
V
N
H
P
A
L
P
G
S
K
G
H
E
F
W
K
R
D
F
T
G
S
S
G
L
F
S
F
V
L
K
K
K
L
N
N
E
E
L
A
N
Y
L
D
N
F
S
L
F
S
M
A
Y
S
W
G
G
Y
E
S
L
I
-
L
A
--
N
Q
P
E
H
I
A
A
I
R
P
Q
----
G
------
E
----
I
----
D
------
F
S
G
T
L
I
R
L
H
I
G
L
E
D
V
D
D
L
I
A
D
L
D
A
G
F
A
R
I
V
------------------
21
PsiBlast_CBE
95.43
35%
-119
- C1 -
4ITX
2
METC_ECOLI
B:
[4-394]
---
K
K
L
D
T
Q
L
V
N
A
G
R
S
K
K
--
Y
-
T
L
G
A
V
N
S
V
I
Q
R
A
S
S
L
V
F
-------
D
S
V
E
A
K
K
-
H
A
T
R
N
R
A
N
G
E
L
F
-
Y
G
R
R
G
T
L
T
H
F
S
L
Q
Q
A
M
C
E
L
E
G
G
A
G
C
V
L
F
P
C
G
A
A
A
V
A
N
S
I
L
A
F
I
E
Q
G
D
H
V
L
M
T
N
T
A
Y
E
S
S
Q
D
F
C
S
K
I
L
S
K
L
G
V
T
T
S
W
F
D
P
-
L
IG
A
--
D
I
V
K
H
L
Q
-
P
N
T
K
I
V
F
L
E
S
P
G
S
I
T
M
E
V
H
D
V
P
A
I
V
A
A
V
R
S
V
V
P
-
D
-
A
I
I
M
I
D
N
T
W
A
A
G
V
L
F
K
A
L
D
F
G
I
D
V
S
I
Q
A
A
T
K
Y
L
V
G
H
S
D
A
M
I
-
G
T
A
V
C
N
-
A
R
-
C
W
E
Q
--
L
R
E
--
N
--
A
Y
L
M
G
Q
M
V
D
A
D
T
A
Y
I
T
S
R
G
L
R
T
L
G
V
R
L
R
Q
H
H
E
S
S
L
K
V
A
E
W
L
A
E
H
P
Q
V
A
R
V
N
H
P
A
L
P
G
S
K
G
H
E
F
W
K
R
D
F
T
G
S
S
G
L
F
S
F
V
L
K
K
K
L
N
N
E
E
L
A
N
Y
L
D
N
F
S
L
F
S
M
A
Y
S
W
G
G
Y
E
S
L
I
-
L
A
--
N
Q
P
E
H
I
A
A
I
R
P
Q
----
G
------
E
----
I
----
D
------
F
S
G
T
L
I
R
L
H
I
G
L
E
D
V
D
D
L
I
A
D
L
D
A
G
F
A
R
I
V
------------------
28
PsiBlast_CBE
95.26
35%
-118
- C1 -
1CL1
1
METC_ECOLI
B:
[4-394]
---
K
K
L
D
T
Q
L
V
N
A
G
R
S
K
K
--
Y
-
T
L
G
A
V
N
S
V
I
Q
R
A
S
S
L
V
F
-------
D
S
V
E
A
K
K
-
H
A
T
R
N
R
A
N
G
E
L
F
-
Y
G
R
R
G
T
L
T
H
F
S
L
Q
Q
A
M
C
E
L
E
G
G
A
G
C
V
L
F
P
C
G
A
A
A
V
A
N
S
I
L
A
F
I
E
Q
G
D
H
V
L
M
T
N
T
A
Y
E
P
S
Q
D
F
C
S
K
I
L
S
K
L
G
V
T
T
S
W
F
D
P
-
L
IG
A
--
D
I
V
K
H
L
Q
-
P
N
T
K
I
V
F
L
E
S
P
G
S
I
T
M
E
V
H
D
V
P
A
I
V
A
A
V
R
S
V
V
P
-
D
-
A
I
I
M
I
D
N
T
W
A
A
G
V
L
F
K
A
L
D
F
G
I
D
V
S
I
Q
A
A
T
K
Y
L
V
G
H
S
D
A
M
I
-
G
T
A
V
C
N
-
A
R
-
C
W
E
Q
--
L
R
E
--
N
--
A
Y
L
M
G
Q
M
V
D
A
D
T
A
Y
I
T
S
R
G
L
R
T
L
G
V
R
L
R
Q
H
H
E
S
S
L
K
V
A
E
W
L
A
E
H
P
Q
V
A
R
V
N
H
P
A
L
P
G
S
K
G
H
E
F
W
K
R
D
F
T
G
S
S
G
L
F
S
F
V
L
K
K
K
L
N
N
E
E
L
A
N
Y
L
D
N
F
S
L
F
S
M
A
Y
S
W
G
G
Y
E
S
L
I
-
L
A
--
N
Q
P
E
H
I
A
A
I
R
P
Q
----
G
------
E
----
I
----
D
------
F
S
G
T
L
I
R
L
H
I
G
L
E
D
V
D
D
L
I
A
D
L
D
A
G
F
A
R
I
V
------------------
22
PsiBlast_CBE
95.13
35%
-117
- C1 -
4ITX
2
METC_ECOLI
A:
[5-394]
----
K
L
D
T
Q
L
V
N
A
G
R
S
K
K
--
Y
-
T
L
G
A
V
N
S
V
I
Q
R
A
S
S
L
V
F
-------
D
S
V
E
A
K
K
-
H
A
T
R
N
R
A
N
G
E
L
F
-
Y
G
R
R
G
T
L
T
H
F
S
L
Q
Q
A
M
C
E
L
E
G
G
A
G
C
V
L
F
P
C
G
A
A
A
V
A
N
S
I
L
A
F
I
E
Q
G
D
H
V
L
M
T
N
T
A
Y
E
S
S
Q
D
F
C
S
K
I
L
S
K
L
G
V
T
T
S
W
F
D
P
-
L
IG
A
--
D
I
V
K
H
L
Q
-
P
N
T
K
I
V
F
L
E
S
P
G
S
I
T
M
E
V
H
D
V
P
A
I
V
A
A
V
R
S
VV
P
-
D
-
A
I
I
M
I
D
N
T
W
A
A
G
V
L
F
K
A
L
D
F
G
I
D
V
S
I
Q
A
A
T
K
Y
L
V
G
H
S
D
A
M
I
-
G
T
A
V
C
N
-
A
R
-
C
W
E
Q
--
L
R
E
--
N
--
A
Y
L
M
G
Q
M
V
D
A
D
T
A
Y
I
T
S
R
G
L
R
T
L
G
V
R
L
R
Q
H
H
E
S
S
L
K
V
A
E
W
L
A
E
H
P
Q
V
A
R
V
N
H
P
A
L
P
G
S
K
G
H
E
F
W
K
R
D
F
T
G
S
S
G
L
F
S
F
V
L
K
K
K
L
N
N
E
E
L
A
N
Y
L
D
N
F
S
L
F
S
M
A
Y
S
W
G
G
Y
E
S
L
I
-
L
A
--
N
Q
P
E
H
I
A
A
I
R
P
Q
----
G
------
E
----
I
----
D
------
F
S
G
T
L
I
R
L
H
I
G
L
E
D
V
D
D
L
I
A
D
L
D
A
G
F
A
R
I
V
------------------
26
PsiBlast_CBE
95.03
35%
-117
- C1 -
4ITG
1
METC_ECOLI
B:
[4-394]
---
K
K
L
D
T
Q
L
V
N
A
G
R
S
K
K
--
Y
-
T
L
G
A
V
N
S
V
I
Q
R
A
S
S
L
V
F
-------
D
S
V
E
A
K
K
-
H
A
T
R
N
R
A
N
G
E
L
F
-
Y
G
R
R
G
T
L
T
H
F
S
L
Q
Q
A
M
C
E
L
E
G
G
A
G
C
V
L
F
P
C
G
A
A
A
V
A
N
S
I
L
A
F
I
E
Q
G
D
H
V
L
M
T
N
T
A
Y
E
S
S
Q
D
F
C
S
K
I
L
S
K
L
G
V
T
T
S
W
F
D
P
-
L
IG
A
--
D
I
V
K
H
L
Q
-
P
N
T
K
I
V
F
L
E
S
P
G
S
I
T
M
E
V
H
D
V
P
A
I
V
A
A
V
R
S
V
V
P
-
D
-
A
I
I
M
I
D
N
T
W
A
A
G
V
L
F
K
A
L
D
F
G
I
D
V
S
I
Q
A
A
T
K
Y
L
V
G
H
S
D
A
M
I
-
G
T
A
V
C
N
-
A
R
-
C
W
E
Q
--
L
R
E
--
N
--
A
Y
L
M
G
Q
M
V
D
A
D
T
A
Y
I
T
S
R
G
L
R
T
L
G
V
R
L
R
Q
H
H
E
S
S
L
K
V
A
E
W
L
A
E
H
P
Q
V
A
R
V
N
H
P
A
L
P
G
S
K
G
H
E
F
W
K
R
D
F
T
G
S
S
G
L
F
S
F
V
L
K
K
K
L
N
N
E
E
L
A
N
Y
L
D
N
F
S
L
F
S
M
A
Y
S
W
G
G
Y
E
S
L
I
-
L
A
--
N
Q
P
E
H
I
A
A
I
R
P
Q
----
G
------
E
----
I
----
D
------
F
S
G
T
L
I
R
L
H
I
G
L
E
D
V
D
D
L
I
A
D
L
D
A
G
F
A
R
I
V
------------------
2
PsiBlast_PDB
94.95
35%
-119
- C1 -
2FQ6
1
METC_ECOLI
A:
[25-414]
----
K
L
D
T
Q
L
V
N
A
G
R
S
K
K
--
Y
-
T
L
G
A
V
N
S
V
I
Q
R
A
S
S
L
V
F
-------
D
S
V
E
A
K
K
-
H
A
T
R
N
R
A
N
G
E
L
F
-
Y
G
R
R
G
T
L
T
H
F
S
L
Q
Q
A
M
C
E
L
E
G
G
A
G
C
V
L
F
P
C
G
A
A
A
V
A
N
S
I
L
A
F
I
E
Q
G
D
H
V
L
M
T
N
T
A
Y
E
P
S
Q
D
F
C
S
K
I
L
S
K
L
G
V
T
T
S
W
F
D
P
-
L
IG
A
--
D
I
V
K
H
L
Q
-
P
N
T
K
I
V
F
L
E
S
P
G
S
I
T
M
E
V
H
D
V
P
A
I
V
A
A
V
R
S
VV
P
-
D
-
A
I
I
M
I
D
N
T
W
A
A
G
V
L
F
K
A
L
D
F
G
I
D
V
S
I
Q
A
A
T
K
Y
L
V
G
H
S
D
A
M
I
-
G
T
A
V
C
N
-
A
R
-
C
W
E
Q
--
L
R
E
--
N
--
A
Y
L
M
G
Q
M
V
D
A
D
T
A
Y
I
T
S
R
G
L
R
T
L
G
V
R
L
R
Q
H
H
E
S
S
L
K
V
A
E
W
L
A
E
H
P
Q
V
A
R
V
N
H
P
A
L
P
G
S
K
G
H
E
F
W
K
R
D
F
T
G
S
S
G
L
F
S
F
V
L
K
K
K
L
N
N
E
E
L
A
N
Y
L
D
N
F
S
L
F
S
M
A
Y
S
W
G
G
Y
E
S
L
I
-
L
A
--
N
Q
P
E
H
I
A
A
I
R
P
Q
----
G
------
E
----
I
----
D
------
F
S
G
T
L
I
R
L
H
I
G
L
E
D
V
D
D
L
I
A
D
L
D
A
G
F
A
R
I
V
------------------
1
PsiBlast_PDB
94.12
35%
-117
- C1 -
1CL2
1
METC_ECOLI
A:
[5-394]
----
K
L
D
T
Q
L
V
N
A
G
R
S
K
K
--
Y
-
T
L
G
A
V
N
S
V
I
Q
R
A
S
S
L
V
F
-------
D
S
V
E
A
K
K
-
H
A
T
R
N
R
A
N
G
E
L
F
-
Y
G
R
R
G
T
L
T
H
F
S
L
Q
Q
A
M
C
E
L
E
G
G
A
G
C
V
L
F
P
C
G
A
A
A
V
A
N
S
I
L
A
F
I
E
Q
G
D
H
V
L
M
T
N
T
A
Y
E
P
S
Q
D
F
C
S
K
I
L
S
K
L
G
V
T
T
S
W
F
D
P
-
L
IG
A
--
D
I
V
K
H
L
Q
-
P
N
T
K
I
V
F
L
E
S
P
G
S
I
T
M
E
V
H
D
V
P
A
I
V
A
A
V
R
S
VV
P
-
D
-
A
I
I
M
I
D
N
T
W
A
A
G
V
L
F
K
A
L
D
F
G
I
D
V
S
I
Q
A
A
T
K
Y
L
V
G
H
S
D
A
M
I
-
G
T
A
V
C
N
-
A
R
-
C
W
E
Q
--
L
R
E
--
N
--
A
Y
L
M
G
Q
M
V
D
A
D
T
A
Y
I
T
S
R
G
L
R
T
L
G
V
R
L
R
Q
H
H
E
S
S
L
K
V
A
E
W
L
A
E
H
P
Q
V
A
R
V
N
H
P
A
L
P
G
S
K
G
H
E
F
W
K
R
D
F
T
G
S
S
G
L
F
S
F
V
L
K
K
K
L
N
N
E
E
L
A
N
Y
L
D
N
F
S
L
F
S
M
A
Y
S
W
G
G
Y
E
S
L
I
-
L
A
--
N
Q
P
E
H
I
A
A
I
R
P
Q
----
G
------
E
----
I
----
D
------
F
S
G
T
L
I
R
L
H
I
G
L
E
D
V
D
D
L
I
A
D
L
D
A
G
F
A
R
I
V
------------------
60
HHSearch
90.18
31%
-115
- C1 -
3COG
5
CGL_HUMAN
A:
[18-400]
-
H
F
A
T
Q
---
A
I
H
V
G
Q
D
P
E
--
Q
W
T
S
R
A
V
V
P
P
I
S
L
S
T
T
F
K
Q
--------------------------------
G
N
P
T
R
N
C
L
E
K
A
V
A
A
L
D
G
A
K
Y
C
L
A
F
A
S
G
L
A
A
T
V
T
-
I
T
H
L
L
K
A
G
D
Q
I
I
C
M
D
D
V
Y
G
G
T
N
R
Y
F
R
Q
V
A
S
E
F
G
L
K
I
S
F
V
D
C
S
K
I
-
K
--
L
L
E
A
A
I
T
-
P
E
T
K
L
V
W
I
E
T
P
T
N
P
T
Q
K
V
I
D
I
E
G
C
A
H
I
V
H
K
--
H
G
D
-
I
I
L
V
V
D
N
T
F
M
S
P
Y
F
Q
R
P
L
A
L
G
A
D
I
S
M
Y
S
A
T
K
Y
M
N
G
H
S
D
V
V
M
-
G
L
V
S
V
N
C
E
S
-
L
H
N
R
--
L
R
F
--
L
--
Q
N
S
L
G
A
V
P
S
P
I
D
C
Y
L
C
N
R
G
L
K
T
L
H
V
R
M
E
K
H
F
K
N
G
M
A
V
A
Q
F
L
E
S
N
P
W
V
E
K
V
I
Y
P
G
L
P
S
H
P
Q
H
E
L
V
K
R
Q
C
T
G
C
T
G
M
V
T
F
Y
I
K
G
T
L
--
Q
H
A
E
I
F
L
K
N
L
K
L
F
T
L
A
E
S
L
G
G
F
E
S
L
A
-
E
L
--
P
A
I
M
T
H
A
--
S
V
L
----
K
------
N
----
D
R
D
V
L
G
------
I
S
D
T
L
I
R
L
S
V
G
L
E
D
E
E
D
L
L
E
D
L
D
Q
A
L
K
A
A
H
P
-----------------
32
PsiBlast_CBE
90.11
31%
-123
- C1 -
1IBJ
3
METC_ARATH
C:
[89-463]
----
T
L
---
L
V
N
L
D
N
K
F
D
--
P
-
F
D
-
A
M
S
T
P
L
Y
Q
T
A
T
F
K
Q
P
S
---------------
A
I
E
N
G
---
P
Y
D
Y
T
R
S
G
N
P
T
R
D
A
L
E
S
L
L
A
K
L
D
K
A
D
R
A
F
C
F
T
S
G
M
A
A
L
S
-
A
V
T
H
L
I
K
N
G
E
E
I
V
A
G
D
D
V
Y
G
G
S
D
R
L
L
S
Q
V
V
P
R
S
G
V
V
V
K
R
V
N
T
-
T
--
K
LD
E
V
A
A
A
I
G
-
P
Q
T
K
L
V
W
L
E
S
P
T
N
P
R
Q
Q
I
S
D
I
R
K
I
S
E
M
A
H
A
--
Q
-
G
-
A
L
V
L
V
D
N
S
I
M
S
P
V
L
S
R
P
L
E
L
G
A
D
I
V
M
H
S
A
T
K
F
I
A
G
H
S
D
V
M
A
-
G
V
L
A
V
K
-
G
E
K
L
A
K
E
--
V
Y
F
--
L
--
Q
N
S
E
G
S
G
L
A
P
F
D
C
W
L
C
L
R
G
I
K
T
M
A
L
R
I
E
K
Q
Q
E
N
A
R
K
I
A
M
Y
L
S
S
H
P
R
V
K
K
V
Y
Y
A
G
L
P
D
H
P
G
H
H
L
H
F
S
Q
A
K
G
A
G
S
V
F
S
F
I
T
G
S
V
A
L
S
K
H
L
---
V
E
T
T
K
Y
F
S
I
A
V
S
F
G
S
V
K
S
L
I
S
M
P
CF
M
S
H
A
S
I
P
--
A
E
V
----
R
------
E
----
A
R---
G
------
L
T
E
D
L
V
R
I
S
A
G
I
E
D
V
D
D
L
I
S
D
L
D
I
A
F
K
T
F
P
L
-----------------
8
PsiBlast_PDB
90.07
31%
-122
- C1 -
1IBJ
4
METC_ARATH
A:
[89-463]
----
T
L
---
L
V
N
L
D
N
K
F
D
--
P
-
F
D
-
A
M
S
T
P
L
Y
Q
T
A
T
F
K
Q
P
S
---------------
A
I
E
N
G
---
P
Y
D
Y
T
R
S
G
N
P
T
R
D
A
L
E
S
L
L
A
K
L
D
K
A
D
R
A
F
C
F
T
S
G
M
A
A
L
S
-
A
V
T
H
L
I
K
N
G
E
E
I
V
A
G
D
D
V
Y
G
G
S
D
R
L
L
S
Q
V
V
P
R
S
G
V
V
V
K
R
V
N
T
-
T
--
K
L
D
E
V
A
A
A
I
G
-
P
Q
T
K
L
V
W
L
E
S
P
T
N
P
R
Q
Q
I
S
D
I
R
K
I
S
E
M
A
H
A
--
Q
-
G
-
A
L
V
L
V
D
N
S
I
M
S
P
V
L
S
R
P
L
E
L
G
A
D
I
V
M
H
S
A
T
K
F
I
A
G
H
S
D
V
M
A
-
G
V
L
A
V
K
-
G
E
K
L
A
K
E
--
V
Y
F
--
L
--
Q
N
S
E
G
S
G
L
A
P
F
D
C
W
L
C
L
R
G
I
K
T
M
A
L
R
I
E
K
Q
Q
E
N
A
R
K
I
A
M
Y
L
S
S
H
P
R
V
K
K
V
Y
Y
A
G
L
P
D
H
P
G
H
H
L
H
F
S
Q
A
K
G
A
G
S
V
F
S
F
I
T
G
S
V
A
L
S
K
H
L
---
V
E
T
T
K
Y
F
S
I
A
V
S
F
G
S
V
K
S
L
I
S
M
P
CF
M
S
H
A
S
I
P
--
A
E
V
----
R
------
E
----
A
R---
G
------
L
T
E
D
L
V
R
I
S
A
G
I
E
D
V
D
D
L
I
S
D
L
D
I
A
F
K
T
F
P
L
-----------------
61
HHSearch
89.80
32%
-116
- C1 -
1IBJ
4
METC_ARATH
A:
[85-463]
A
S
V
S
T
L
---
L
V
N
L
D
N
K
F
D
----
P
F
D
A
M
S
T
P
L
Y
Q
T
A
T
F
K
Q
P
S
A
I
E
------------------
N
G
P
Y
D
Y
T
R
S
G
N
P
T
R
D
A
L
E
S
L
L
A
K
L
D
K
A
D
R
A
F
C
F
T
S
G
M
A
A
L
S
A
V
T
-
H
L
I
K
N
G
E
E
I
V
A
G
D
D
V
Y
G
G
S
D
R
L
L
S
Q
V
V
P
R
S
G
V
V
V
K
R
V
N
T
T
K
L
-
D
--
E
V
A
A
A
I
G
-
P
Q
T
K
L
V
W
L
E
S
P
T
N
P
R
Q
Q
I
S
D
I
R
K
I
S
E
M
A
H
A
--
Q
-
G
-
A
L
V
L
V
D
N
S
I
M
S
P
V
L
S
R
P
L
E
L
G
A
D
I
V
M
H
S
A
T
K
F
I
A
G
H
S
D
V
M
A
-
G
V
L
A
V
K
-
G
E
K
L
A
K
E
--
V
Y
F
--
L
--
Q
N
S
E
G
S
G
L
A
P
F
D
C
W
L
C
L
R
G
I
K
T
M
A
L
R
I
E
K
Q
Q
E
N
A
R
K
I
A
M
Y
L
S
S
H
P
R
V
K
K
V
Y
Y
A
G
L
P
D
H
P
G
H
H
L
H
F
S
Q
A
K
G
A
G
S
V
F
S
F
I
T
G
S
V
---
A
L
S
K
H
L
V
E
T
T
K
Y
F
S
I
A
V
S
F
G
S
V
K
S
L
I
-
S
M
--
P
C
F
M
S
H
A
--
S
I
P
----
A
------
E
VREA
R
----
G
------
L
T
E
D
L
V
R
I
S
A
G
I
E
D
V
D
D
L
I
S
D
L
D
I
A
F
K
T
F
P
L
-----------------
62
HHSearch
89.61
27%
-113
- C1 -
1E5E
5
?
A:
[6-397]
M
T
P
A
T
A
---
C
I
H
A
N
P
Q
K
D
----
Q
F
G
A
A
I
P
P
I
Y
Q
T
S
T
F
V
F
D
N
C
Q
Q
G
G
N
R
F
A
G
Q
----------
E
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
V
L
T
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
F
G
I
Q
V
D
F
I
N
T
A
I
P-
G
--
E
V
K
K
H
M
K
-
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
H
S
Q-
E
-
G
-
V
L
V
I
A
D
N
T
F
C
S
P
M
I
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
-
G
L
I
C
G
K
-
A
D
-
L
L
Q
Q
--
I
R
M
--
V
GI
K
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
R
M
Y
G
S
M
I
T
F
I
L
K
S
G
F
--
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
L
I
-
Q
H
--
P
A
S
M
T
H
A
--
V
V
P
----
K
E
E
R
E
--
A
----
A
----
G
------
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
L
L
R
-----------------
69
HHSearch
89.45
29%
-120
- C1 -
2RFV
1
?
A:
[8-396]
-
G
F
N
T
Q
---
I
V
H
A
G
Q
Q
P
D
--
P
-
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
E
Q
G
A
A
R
F
---------------
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
G
I
N
V
R
F
V
D
A
A
K
P
-
E
--
E
I
R
A
A
M
R
-
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
--
Q
-
G
-
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
G
H
-
G
D
V
I
G
G
I
I
V
G
K
-
Q
E
-
F
I
D
Q
--
A
R
F
VG
L
--
K
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
L
P
G
G
I
I
S
F
E
I
A
G
G
L
--
E
A
G
R
R
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
E
T
L
I
-
Q
H
--
P
A
S
M
T
H
S
--
P
V
A
P
E
E
R
L
------
K
----
A
----
G
------
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
A
T
------------------
59
HHSearch
88.90
28%
-112
- C1 -
1QGN
2
?
A:
[56-445]
-
S
D
G
S
V
---
A
I
H
A
G
E
R
L
G
RG
I
-
V
T
D
A
I
T
T
P
V
V
N
T
S
A
Y
F
F
N
K
T
S
E
L
I
D
F
K
E
K
R
----------
R
A
S
F
E
Y
G
R
Y
G
N
P
T
T
V
V
L
E
E
K
I
S
A
L
E
G
A
E
S
T
L
L
M
A
S
G
M
C
A
S
T
V
M
L
L
A
L
V
P
A
G
G
H
I
V
T
T
T
D
C
Y
R
K
T
R
I
F
I
E
T
I
L
P
K
M
G
I
T
A
T
V
I
D
P
A
D
V
-
G
--
A
L
E
L
A
L
N
Q
K
K
V
N
L
F
F
T
E
S
P
T
N
P
F
L
R
C
V
D
I
E
L
V
S
K
L
C
H
E
--
K
-
G
-
A
L
V
C
I
D
G
T
F
A
T
P
L
N
Q
K
A
L
A
L
G
A
D
L
V
L
H
S
A
T
K
F
L
G
G
H
N
D
V
L
A
-
G
C
I
S
G
P
-
L
K
-
L
V
S
E
--
I
R
N
--
L
--
H
H
I
L
G
G
A
L
N
P
N
A
A
Y
L
I
I
R
G
M
K
T
L
H
L
R
V
Q
Q
Q
N
S
T
A
L
R
M
A
E
I
L
E
A
H
P
K
V
R
H
V
Y
Y
P
G
L
Q
S
H
P
E
H
H
I
A
K
K
Q
M
T
G
F
G
G
A
V
S
F
E
V
D
G
D
L
--
L
T
T
A
K
F
V
D
A
L
K
I
P
Y
I
A
P
S
F
G
G
C
E
S
I
V
-
D
Q
--
P
A
I
M
S
Y
W
--
D
L
S
----------------
Q
----
S
D
R
A
K
YG
I
M
D
N
L
V
R
F
S
F
G
V
E
D
F
D
D
L
K
A
D
I
L
Q
A
L
D
S
I
-------------------
71
HHSearch
88.67
30%
-115
- C1 -
1CS1
-
METB_ECOLI
A:
[4-385]
-
K
Q
A
T
I
---
A
V
R
S
G
L
N
D
D
--
E
-
Q
Y
G
C
V
V
P
P
I
H
L
S
S
T
Y
N
F
T
G
F
N
E
P
------------------
R
A
H
D
Y
S
R
R
G
N
P
T
R
D
V
V
Q
R
A
L
A
E
L
E
G
G
A
G
A
V
L
T
N
T
G
M
S
A
I
H
L
V
T
T
V
F
L
K
P
G
D
L
L
V
A
P
H
D
C
Y
G
G
S
Y
R
L
F
D
S
L
A
K
R
G
C
Y
R
V
L
F
V
D
Q
G
D
E
-
Q
--
A
L
R
A
A
L
A
-
E
K
P
K
L
V
L
V
E
S
P
S
N
P
L
L
R
V
V
D
I
A
K
I
C
H
L
A
R
E
--
V
-
G
-
A
V
S
V
V
D
N
T
F
L
S
P
A
L
Q
N
P
L
A
L
G
A
D
L
V
L
H
S
C
T
K
Y
L
N
G
H
S
D
V
V
A
-
G
V
V
I
A
K
D
P
D
-
V
V
T
E
--
L
A
W
--
W
--
A
N
N
I
G
V
T
G
G
A
F
D
S
Y
L
L
L
R
G
L
R
T
L
V
P
R
M
E
L
A
Q
R
N
A
Q
A
I
V
K
Y
L
Q
T
Q
P
L
V
K
K
L
Y
H
P
S
L
P
E
N
Q
G
H
E
I
A
A
R
Q
Q
K
G
F
G
A
M
L
S
F
E
L
D
G
D
E
--
Q
T
L
R
R
F
L
G
G
L
S
L
F
T
L
A
E
S
L
G
G
V
E
S
L
I
-
S
H
--
A
A
T
M
T
H
A
--
G
M
A
P
E
A
R
A
------
A
----
A
----
G
------
I
S
E
T
L
L
R
I
S
T
G
I
E
D
G
E
D
L
I
A
D
L
E
N
G
F
R
A
A
N
K
G
----------------
18
PsiBlast_PDB
87.70
27%
-116
- C1 -
1E5E
5
?
A:
[19-395]
-----------------
K
--
D
-
Q
F
G
A
A
I
P
P
I
Y
Q
T
S
T
F
V
F
D
------
N
C
Q
Q
G
G
N
R
F
A
----
G
Q
E
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
V
L
T
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
F
G
I
Q
V
D
F
I
N
T
-
A
IP
G
--
E
V
K
K
H
M
K
-
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
H
S
--
Q
-
E
G
V
L
V
I
A
D
N
T
F
C
S
P
M
I
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
V
V
A
-
G
L
I
C
G
K
-
A
D
-
L
L
Q
Q
I
R
M
V
G
--
I
--
K
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
R
M
Y
G
S
M
I
T
F
I
L
K
S
G
F
--
E
G
A
K
K
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
E
S
L
I
-
Q
----
H
P
A
S
M
T
--
H
A
V
----
V
P
K
E
E
R
E
A
----
A
----
G
------
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
L
L
R
-----------------