@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0495: (2015-12-02 )
MGRAIGIDLGTTNSCVAIQGKIIENKEGARTTPSVVAFTSSGERLIGAPAKRQATTNASNTFFATKRLIGRQYGDPEMKDLNVPYKVFAAKNGDAWIKTTDGKEYSPSQIGAFILQNLKEAAEAYLGEEVKDAVITVPAYFNDSQRQATKDAGKIAGLNVLRIVNEPTAAALAYGLDKKHGHTIVVYDLGGGTFDVSILEIGDGVFEVKATNGDTHLGGEDFDNAIVSYLLDEFKKSNGIGLKNDPMAMQRIKEAAEKAKIELSSAMETEINLPFITADANGPKHLNMKLTRAKLESLVNDLIERTMTPCKKALEDTGLSANQIGEVVLVGGMTRMPRVIEKVKEFFGKDPHRGVNPDEVVAIGAAIQAGIVQGDVRDVLLLDVTPLSLGIETLGGVFTPLIERNTTIPTKKSQVFSTAEDNQTAVTIKVHQGERKLAVDNKLLGQFSLEGIPPAPRGIPQIEVTFDIDANGIVHVSAKDKATGKEQKIRIQSSGGLSESEINRMIREAEEKAQEDEKRKKFVEVKNQADSLVHSTEKSLKEYGDKVSPEDKSAIENAVNELKEASKSDNIDDVDSIQQKITNLSQLSMKLGETIYKESQQQQGKESSAGSSTTNEEEKVVDSDYQDIDNKEENK
Atome Classification :
(89 SA)
.........10.......----.----20---.----........30........40........50........60........70.....----..-.-80-.--.-.-......90...-..--...100---..----.......110.......120.......130.......140.......150.......160.......170......--.----180---.-.......190.......200---........-210.......220.......230......-.240.......250.......260.--......--270.......280.......290.......300.-......310....--...320.......330.......340.....-.-.350.......360.......370...----....380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490....-...500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MG
R
A
I
G
I
DLGTTN
S
C
V
A
I
----
Q
----
G
----
K
----
I
IENKEGARTT
P
S
V
V
A
FTSSGE
R
L
IGAPAKRQATTNASN
T
F
F
A
T
K
R
L
I
G
RQYGDP----EM-K-D--L--N-V-
P
Y
K
V
F
A
AKNGD-
A
W
--
I
K
TT-----DG----KEY
S
P
S
Q
I
G
A
F
I
L
Q
N
L
K
E
A
A
E
A
Y
L
G
E
EVKD
A
V
I
T
V
P
A
YFND
S
Q
R
Q
A
T
KDAGKIAG
L
N
V
L
R
IVNEP
T
A
A
A
L
A
YGLDK--K----HG----
H
-
T
I
V
V
Y
DLGG
G
T
F
D
V
S
I
L
EI----GD
G
V
F
E
V
K
-ATNGDTHLGG
E
D
F
D
N
A
I
V
S
Y
L
L
D
E
F
K
KSN-GIGLKN
D
P
M
A
M
Q
R
I
K
E
A
A
E
K
A
K
I
E
L--SSAMET--EIN
L
P
F
I
TADANGP
K
H
L
N
M
K
L
T
R
A
K
L
E
S
L
V
N
D
L
I
-
E
R
T
M
T
P
C
K
K
A
L
E
D--TGL
S
A
N
QI
G
E
V
V
L
VGGMTR
M
P
R
V
I
E
K
V
K
E
F
F-G-KDPHRGV
N
P
D
E
V
V
A
I
G
A
A
I
Q
A
G
I
VQGD----V
R
D
V
L
L
L
DV
T
P
L
S
L
G
I
E
T
L
G
G
V
F
T
P
L
IERNTTIPTKKSQ
V
F
STAEDN
Q
T
A
V
T
I
K
VHQGE
R
K
LAVD
N
K
L
L
G
QFSLEGIPPAPRGI
P
Q
I
E
V
T
F
D
IDAN
G
I
V
H
V
SAKDKATGK
E
Q
K
I
R
I
QSSGG-L
S
E
S
E
I
N
R
M
I
R
E
A
E
E
K
A
Q
E
D
E
K
R
K
K
F
V
E
V
K
N
Q
A
D
S
L
V
H
S
T
E
K
S
L
K
E
YGDKVSP
E
D
K
S
A
I
E
N
A
V
N
E
L
K
E
ASKSDNID
D
V
D
S
I
Q
Q
K
I
T
N
L
S
Q
L
S
M
K
L
G
E
T
I
Y
K
E
S
Q
Q
QQGKESSAGSSTTN
E
E
E
K
VVDS
D
Y
QDIDNKEENK
22
PsiBlast_CBE
94.07
63%
-69
- C3 -
4JN4
12
DNAK_ECOLI
B:
[2-596]
-
G
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
----
M
----
D
GTTP
R
----
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
D
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
R
R
F
Q
D
E
----
E
V
Q
R
-
D
--
V
--
S
-
I
M
P
F
K
I
I
A
A
D
N
G
D
-
A
W
--
V
E
V
K
------
G
----
Q
K
M
A
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
--
G
----
T
G
----
N
R
T
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
DEVD
G
E
K
T
F
E
V
L
-
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
-
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
--
S
S
A
Q
Q
T
--
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
-
N
R
S
I
E
P
L
K
V
A
L
Q
D
--
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
D
----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
G
----
G
A
V
T
I
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
S
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
---
E
D
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
M
E
I
A
Q
Q
--------------------------------------
3
PsiBlast_PDB
93.69
63%
-71
- C3 -
4JN4
12
DNAK_ECOLI
A:
[2-596]
-
G
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
----
M
----
D
GT
T
P
R
----
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
D
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
R
R
F
Q
D
E
----
E
V
Q
R
-
D
--
V
--
S
-
I
M
P
F
K
I
I
A
A
D
N
G
D
-
A
W
--
V
E
V
K
------
G
----
Q
K
M
A
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
--
G
----
T
G
----
N
R
T
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
D
E
V
D
G
E
K
T
F
E
V
L
-
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
-
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
--
S
S
A
Q
Q
T
--
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
-
N
R
S
I
E
P
L
K
V
A
L
Q
D
--
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
D
----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
G
----
G
A
V
T
I
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
S
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
---
E
D
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
M
E
I
A
Q
Q
--------------------------------------
21
PsiBlast_CBE
93.62
63%
-67
- C3 -
4JNE
11
DNAK_ECOLI
B:
[2-596]
-
G
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
----
M
----
D
GTTP
R
----
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
D
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
R
R
F
Q
D
E
----
E
V
Q
R
-
D
--
V
--
S
-
I
M
P
F
K
I
I
A
A
D
N
G
D
-
A
W
--
V
E
V
K
------
G
----
Q
K
M
A
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
--
G
----
T
G
----
N
R
T
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
DEVD
G
E
K
T
F
E
V
L
-
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
-
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
--
S
S
A
Q
Q
T
--
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
-
N
R
S
I
E
P
L
K
V
A
L
Q
D
--
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
D
----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
G
----
G
A
V
T
I
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
S
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
---
E
D
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
M
E
I
A
Q
Q
--------------------------------------
4
PsiBlast_PDB
93.45
63%
-69
- C3 -
4JNE
12
DNAK_ECOLI
A:
[2-596]
-
G
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
----
M
----
D
GT
T
P
R
----
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
D
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
R
R
F
Q
D
E
----
E
V
Q
R
-
D
--
V
--
S
-
I
M
P
F
K
I
I
A
A
D
N
G
D
-
A
W
--
V
E
V
K
------
G
----
Q
K
M
A
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
--
G
----
T
G
----
N
R
T
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
D
E
V
D
G
E
K
T
F
E
V
L
-
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
-
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
--
S
S
A
Q
Q
T
--
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
-
N
R
S
I
E
P
L
K
V
A
L
Q
D
--
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
D
----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
G
----
G
A
V
T
I
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
S
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
---
E
D
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
M
E
I
A
Q
Q
--------------------------------------
2
PsiBlast_PDB
92.76
62%
-70
- C3 -
4B9Q
1
DNAK_ECOLI
A:
[2-602]
-
G
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
----
M
----
D
GT
T
P
R
----
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
D
G
C
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
R
R
F
Q
D
E
----
E
V
Q
R
-
D
--
V
--
S
-
I
M
P
F
K
I
I
A
A
D
N
G
D
-
A
W
--
V
E
V
K
------
G
----
Q
K
M
A
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
--
G
----
T
G
----
N
R
T
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
D
E
V
D
G
E
K
T
F
E
V
L
-
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
-
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
--
S
S
A
Q
Q
T
--
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
-
N
R
S
I
E
P
L
K
V
A
L
Q
D
--
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
D
----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
T
A
E
D
N
Q
S
A
V
T
I
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
S
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
C
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
---
E
D
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
M
E
I
----
A
------------------------------------
1
PsiBlast_PDB
91.94
63%
-71
- C4 -
2KHO
-
DNAK_ECOLI
A:
[4-603]
---
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
----
M
----
D
GT
T
P
R
----
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
D
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
R
R
F
Q
D
E
----
E
V
Q
R
-
D
--
V
--
S
-
I
M
P
F
K
I
I
A
A
D
N
G
D
-
A
W
--
V
E
V
K
------
G
----
Q
K
M
A
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
--
G
----
T
G
----
N
R
T
I
A
V
Y
D
L
G
G
G
T
F
D
I
S
I
I
E
I
D
EVD
G
E
K
T
F
E
V
L
-
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
-
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
--
S
S
A
Q
Q
T
--
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
-
N
R
S
I
E
P
L
K
V
A
L
Q
D
--
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
D
----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
T
A
E
D
N
Q
S
A
V
T
I
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
S
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
D
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
---
E
D
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
M
E
I
----
A
Q
-----------------------------------
102
HHSearch
84.75
68%
-69
- C4 -
2V7Y
2
DNAK_GEOKA
A:
[1-504]
M
S
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
V
L
E
GG
E
----
V
----
K
----
V
I
P
N
P
E
G
N
R
T
T
P
S
V
V
A
F
K
N
-
G
E
R
L
V
G
E
V
A
K
R
Q
A
I
T
N
P
-
N
T
I
I
S
I
K
R
H
M
G
T
D
Y
K
V
-------------------------------------
E
I
------
E
G
----
K
Q
Y
T
P
Q
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
P
V
T
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
--
E
----
E
D
----
Q
-
T
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
L
----
G
D
G
V
F
E
V
K
-
A
T
A
G
D
N
H
L
G
G
D
D
F
D
Q
V
I
I
D
Y
L
V
N
Q
F
K
Q
E
H
-
G
I
D
L
S
K
D
K
M
A
L
Q
R
L
K
D
A
A
E
K
A
K
K
E
L
--
S
G
V
T
Q
T
--
Q
I
S
L
P
F
I
S
A
N
E
N
G
P
L
H
L
E
M
T
L
T
R
A
K
F
E
E
L
S
A
H
L
V
-
E
R
T
M
G
P
V
R
Q
A
L
Q
D
--
A
G
L
T
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
R
E
L
-
G
-
K
E
P
H
K
G
V
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
A
G
E
----
V
K
D
V
V
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
F
T
K
L
I
E
R
N
T
T
I
P
T
S
K
S
Q
V
F
T
T
A
A
D
N
Q
T
T
V
D
I
H
V
L
Q
G
E
R
P
M
A
A
D
N
K
S
L
G
R
F
Q
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
V
H
V
R
A
K
D
L
G
T
N
K
E
Q
S
I
T
I
K
S
S
S
G
-
L
S
E
E
E
I
Q
R
M
I
K
E
A
E
E
N
A
E
A
D
R
K
R
K
E
A
A
E
L
--------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
84.40
64%
-71
- C4 -
2V7Y
2
DNAK_GEOKA
A:
[1-504]
M
S
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
V
L
E
GG
E
----
V
----
K
----
V
I
P
N
P
E
G
N
R
T
T
P
S
V
V
A
F
-
K
N
G
E
R
L
V
G
E
V
A
K
R
Q
A
I
T
N
-
P
N
T
I
I
S
I
K
R
H
M
G
T
D
Y
------------------------
K
V
--------------
E
I
-----
E
G
----
K
Q
Y
T
P
Q
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
P
V
T
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
--
E
----
E
D
----
Q
-
T
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
L
----
G
D
G
V
F
E
V
K
-
A
T
A
G
D
N
H
L
G
G
D
D
F
D
Q
V
I
I
D
Y
L
V
N
Q
F
K
Q
E
H
-
G
I
D
L
S
K
D
K
M
A
L
Q
R
L
K
D
A
A
E
K
A
K
K
E
L
--
S
G
V
T
Q
T
--
Q
I
S
L
P
F
I
S
A
N
E
N
G
P
L
H
L
E
M
T
L
T
R
A
K
F
E
E
L
S
A
H
L
V
-
E
R
T
M
G
P
V
R
Q
A
L
Q
D
--
A
G
L
T
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
R
E
L
-
G
-
K
E
P
H
K
G
V
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
A
G
E
----
V
K
D
V
V
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
F
T
K
L
I
E
R
N
T
T
I
P
T
S
K
S
Q
V
F
T
T
A
A
D
N
Q
T
T
V
D
I
H
V
L
Q
G
E
R
P
M
A
A
D
N
K
S
L
G
R
F
Q
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
V
H
V
R
A
K
D
L
G
T
N
K
E
Q
S
I
T
I
K
S
S
S
G
-
L
S
E
E
E
I
Q
R
M
I
K
E
A
E
E
N
A
E
A
D
R
K
R
K
E
A
A
E
L
--------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
83.72
64%
-72
- C4 -
4ANI
-
DNAK_GEOKA
C:
[1-509]
M
S
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
V
L
E
GG
E
----
V
----
K
----
V
I
P
N
P
E
G
N
R
T
T
P
S
V
V
A
F
-
K
N
G
E
R
L
V
G
E
V
A
K
R
Q
A
I
T
N
-
P
N
T
I
I
S
I
K
R
H
M
G
T
D
Y
------------------------
K
V
--------------
E
I
-----
E
G
----
K
Q
Y
T
P
Q
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
P
V
T
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
--
E
----
E
D
----
Q
-
T
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
L
----
G
D
G
V
F
E
V
K
-
A
T
A
G
D
N
H
L
G
G
D
D
F
D
Q
V
I
I
D
Y
L
V
N
Q
F
K
Q
E
H
-
G
I
D
L
S
K
D
K
M
A
L
Q
R
L
K
D
A
A
E
K
A
K
K
E
L
--
S
G
V
T
Q
T
--
Q
I
S
L
P
F
I
S
A
N
E
N
G
P
L
H
L
E
M
T
L
T
R
A
K
F
E
E
L
S
A
H
L
V
-
E
R
T
M
G
P
V
R
Q
A
L
Q
D
--
A
G
L
T
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
R
E
L
-
G
-
K
E
P
H
K
G
V
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
A
G
E
----
V
K
D
V
V
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
F
T
K
L
I
E
R
N
T
T
I
P
T
S
K
S
Q
V
F
T
T
A
A
D
N
Q
T
T
V
D
I
H
V
L
Q
G
E
R
P
M
A
A
D
N
K
S
L
G
R
F
Q
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
V
H
V
R
A
K
D
L
G
T
N
K
E
Q
S
I
T
I
K
S
S
S
G
-
L
S
E
E
E
I
Q
R
M
I
K
E
A
E
E
N
A
E
A
D
R
K
R
K
E
A
A
E
L
R
N
E
A
D
---------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
81.42
52%
-68
- C3 -
3C7N
9
HSP7C_BOVIN
B:
[4-547]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
V
E
--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
EYKG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K-----
D
L
L
L
L
D
V
T
P
L
S
L
G
I
E
T
A
G
G
V
M
T
V
L
I
K
R
N
T
T
I
P
T
K
Q
T
Q
T
F
T
T
Y
S
D
N
Q
P
G
V
L
I
Q
V
Y
E
G
E
R
A
M
T
K
D
N
N
L
L
G
K
F
E
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
L
N
V
S
A
V
D
K
S
T
G
K
E
N
K
I
T
I
T
N
D
K
G
R
L
S
K
E
D
I
E
R
M
V
Q
E
A
E
K
Y
K
A
E
D
E
K
Q
R
D
K
V
S
S
K
N
S
L
E
S
Y
A
F
-----------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
80.73
52%
-65
- C3 -
1YUW
-
HSP7C_BOVIN
A:
[4-554]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
V
E
--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
A
A
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
KSEN
V
Q
D
L
L
L
L
D
V
T
P
L
S
L
G
I
E
T
A
G
G
V
M
T
V
L
I
K
R
N
T
T
I
P
T
K
Q
T
Q
T
F
T
T
Y
S
D
N
Q
P
G
V
L
I
Q
V
Y
E
G
E
R
A
M
T
K
D
N
N
L
L
G
K
F
E
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
L
N
V
S
A
V
D
K
S
T
G
K
E
N
K
I
T
I
T
N
D
K
G
R
L
S
K
E
D
I
E
R
M
V
Q
E
A
E
K
Y
K
A
E
D
E
K
Q
R
D
K
V
S
S
K
N
S
L
E
S
Y
A
F
N
M
K
A
T
V
E
----------------------------------------------------------------------------------------------
123
Fugue
77.17
65%
-88
* C3 *
1DKG
-
DNAK_ECOLI
D:
[3-383]
--
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
----
M
DGTT
P
----
R
----
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
D
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
R
R
F
Q
D
E
----
E
V
-
Q
-
R
--
D
VS
I
-
M
-
P
F
K
I
I
A
A
D
N
G
D
-
A
W
--
V
E
V
-KG---------
Q
K
M
A
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
--------
T
GN--
R
-
T
I
A
V
Y
D
L
G
G
G
T
F
D
I
S
I
I
E
I
----
D
E
K
T
F
E
V
L
A-
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
-
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
SS--
A
Q
Q
T
--
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N-
R
S
I
E
L
L
K
V
A
L
Q
D
AG--
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
G--
K
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
76.65
64%
-85
- C3 -
1DKG
-
DNAK_ECOLI
D:
[3-382]
--
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
----
M
----
D
GTTP
R
----
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
D
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
R
R
F
Q
D
E
----
E
V
Q
R
-
D
--
V
--
S
-
I
M
P
F
K
I
I
A
A
D
N
G
D
-
A
W
--
V
E
V
K
------
G
----
Q
K
M
A
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
-------
T
G
----
N
R
T
I
A
V
Y
D
L
G
G
G
T
F
D
I
S
I
I
E
I
D----
E
K
T
F
E
V
L
-
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
-
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
--
S
S
A
Q
Q
T
--
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
-
N
R
S
I
E
L
L
K
V
A
L
Q
D
--
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
-
G
-
K
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
75.21
52%
-85
- C3 -
4IO8
1
HS71A_HUMAN
A:
[6-379]
---
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
-
K
-------
H
-
W
-
P
F
Q
V
I
--
N
D
G
D
K
P
K
--
V
Q
V
S
Y
KG--
D
T
----
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
TG
K
----
G
E
----
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
K
-
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
-
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
I
D
------
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
--
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
75.03
52%
-83
- C3 -
3LDP
1
GRP78_HUMAN
A:
[4-383]
V
G
T
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
NG
R
----
V
----
E
----
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
T
W
N
D
P
----
S
V
-
Q
Q
D
--
I
--
K
F
L
-
P
F
K
V
V
E
K
K
T
-
K
-
P
Y
--
I
Q
V
D
-----
I
G
GG
Q
T
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
R
----
E
G
----
E
K
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
G
V
F
E
V
V
-
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
-
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
--
S
S
Q
H
Q
A
--
R
I
E
I
E
S
F
Y
E
G
E
D
----
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
--
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
74.42
49%
-83
- C3 -
3L4I
3
?
A:
[19-399]
-
G
P
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
----
W
----
R
----
N
D
T
V
D
I
V
P
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
E
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
R
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
K
F
D
D
Q
----
A
V
-
Q
-
S
D
M
T
--
H
-
W
-
P
F
K
V
V
R
G
P
K
D
K
-
P
I
--
I
S
V
N
Y
LG--
E
K
----
K
E
F
H
A
E
E
I
S
A
M
V
L
Q
K
M
K
E
I
S
E
A
Y
L
G
R
Q
I
K
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
G
T
G
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
E
D
G
I
F
E
V
K
-
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
E
F
C
V
Q
D
F
K
R
K
N
R
G
M
D
L
T
T
N
A
R
A
L
R
R
L
R
T
Q
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
T
I
E
L
D
S
L
Y
E
G
I
D
----
Y
S
V
A
I
S
R
A
R
F
E
E
L
C
A
D
Y
F
-
R
A
T
L
A
P
V
E
K
V
L
K
D
--
A
G
M
D
K
R
S
V
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
A
L
I
Q
E
F
F
N
G
-
K
E
P
C
K
A
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
N
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
74.35
52%
-81
- C3 -
3LDO
1
GRP78_HUMAN
B:
[4-383]
V
G
T
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
FKNG
R
----
V
----
E
----
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
T
W
N
D
P
----
S
V
-
Q
Q
D
--
I
--
K
F
L
-
P
F
K
V
V
E
K
K
T
-
K
-
P
Y
--
I
Q
V
D
-----
I
G
GGQT
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
R
----
E
G
----
E
K
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
G
V
F
E
V
V
-
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
-
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
--
S
S
Q
H
Q
A
--
R
I
E
I
E
S
F
Y
E
G
E
D
----
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
--
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
74.34
52%
-92
- C3 -
3D2F
2
HS71A_HUMAN
D:
[6-382]
---
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
FQ--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
VVQS
D
M
-
K
-------
H
-
W
-
P
F
Q
V
I
--
N
D
G
D
K
P
K
--
V
Q
V
S
YKG--
E
T
----
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
TG
K
----
G
E
----
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
K
-
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
-
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
SL
E
I
D
S
L
F
E
G
I
D
------
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
--
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
74.33
52%
-81
- C3 -
3LDN
-
GRP78_HUMAN
A:
[27-407]
V
G
T
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
NG
R
----
V
----
E
----
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
T
W
N
D
P
----
S
V
-
Q
Q
D
--
I
--
K
F
L
-
P
F
K
V
V
E
K
K
T
-
K
-
P
Y
--
I
Q
V
D
-----
I
G
GG
Q
T
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
R
----
E
G
----
E
K
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
G
V
F
E
V
V
-
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
-
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
--
S
S
Q
H
Q
A
--
R
I
E
I
E
S
F
Y
E
G
E
D
----
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
--
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
74.23
49%
-81
- C3 -
3KVG
4
?
A:
[19-399]
-
G
P
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
----
W
----
R
----
N
D
T
V
D
I
V
P
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
E
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
R
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
K
F
D
D
Q
----
A
V
-
Q
-
S
D
M
T
--
H
-
W
-
P
F
K
V
V
R
G
P
K
D
K
-
P
I
--
I
S
V
N
Y
LG--
E
K
----
K
E
F
H
A
E
E
I
S
A
M
V
L
Q
K
M
K
E
I
S
E
A
Y
L
G
R
Q
I
K
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
G
T
G
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
E
D
G
I
F
E
V
K
-
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
E
F
C
V
Q
D
F
K
R
K
N
R
G
M
D
L
T
T
N
A
R
A
L
R
R
L
R
T
Q
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
T
I
E
L
D
S
L
Y
E
G
I
D
----
Y
S
V
A
I
S
R
A
R
F
E
E
L
C
A
D
Y
F
-
R
A
T
L
A
P
V
E
K
V
L
K
D
--
A
G
M
D
K
R
S
V
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
A
L
I
Q
E
F
F
N
G
-
K
E
P
C
K
A
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
N
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
74.20
52%
-80
- C3 -
3LDL
1
GRP78_HUMAN
A:
[4-383]
V
G
T
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
NG
R
----
V
----
E
----
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
T
W
N
D
P
----
S
V
-
Q
Q
D
--
I
--
K
F
L
-
P
F
K
V
V
E
K
K
T
-
K
-
P
Y
--
I
Q
V
D
-----
I
G
GG
Q
T
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
R
----
E
G
----
E
K
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
G
V
F
E
V
V
-
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
-
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
--
S
S
Q
H
Q
A
--
R
I
E
I
E
S
F
Y
E
G
E
D
----
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
--
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
74.11
52%
-86
- C3 -
1HJO
2
HS71A_HUMAN
A:
[4-380]
---
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
V
E
--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
-
K
-------
H
-
W
-
P
F
Q
V
I
--
N
D
G
D
K
P
K
--
V
Q
V
S
Y
KG--
E
T
----
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
TG
K
----
G
E
----
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
K
-
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
-
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
I
D
------
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
--
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
73.94
52%
-83
- C3 -
3IUC
3
GRP78_HUMAN
C:
[25-406]
V
G
T
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
FKNG
R
----
V
----
E
----
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
T
W
N
D
P
----
S
V
-
Q
Q
D
--
I
--
K
F
L
-
P
F
K
V
V
E
K
K
T
-
K
-
P
Y
--
I
Q
V
D
-----
I
G
GGQT
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--------
G
----
E
K
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
G
V
F
E
V
V
-
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
-
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
--
S
S
Q
H
Q
A
--
R
I
E
I
E
S
F
Y
E
G
E
D
----
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
--
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
73.79
50%
-81
- C3 -
3FE1
2
HSP76_HUMAN
C:
[24-402]
-
E
L
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
Q
----
G
----
R
V
E
--
I
L
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
V
G
D
A
A
K
S
Q
A
A
L
N
P
H
N
T
V
F
D
A
K
R
L
I
G
R
K
F
A
D
T
----
T
V
-
Q
S
D
--
M
K
-
H
-
W
-
P
F
R
V
-
V
S
E
G
G
K
-
P
K
--
V
R
V
C
Y
RG--
E
D
----
K
T
F
Y
P
E
E
I
S
S
M
V
L
S
K
M
K
E
T
A
E
A
Y
L
G
Q
P
V
K
H
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
--
R
----
G
A
G
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
V
L
S
I
----
D
A
G
V
F
E
V
K
-
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
M
E
E
F
R
R
K
H
-
G
K
D
L
S
G
N
K
R
A
L
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
T
L
E
I
D
S
L
F
E
G
V
D
------
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
--
A
K
L
D
K
A
Q
I
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
V
L
M
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
73.79
52%
-83
- C3 -
3IUC
2
GRP78_HUMAN
A:
[26-404]
-
G
T
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
NG
R
----
V
----
E
----
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
T
W
N
D
P
----
S
V
-
Q
Q
D
--
I
--
K
F
L
-
P
F
K
V
V
E
K
K
T
-
K
-
P
Y
--
I
Q
V
D
-----
I
G
GG
Q
T
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
R
----
E
G
----
E
K
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
G
V
F
E
V
V
-
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
-
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
--
S
S
Q
H
Q
A
--
R
I
E
I
E
S
F
Y
E
G
E
D
----
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
--
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
73.61
52%
-82
- C3 -
3LDL
2
GRP78_HUMAN
B:
[4-383]
V
G
T
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
FKNG
R
----
V
----
E
----
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
T
W
N
D
P
----
S
V
-
Q
Q
D
--
I
--
K
F
L
-
P
F
K
V
V
E
K
K
T
-
K
-
P
Y
--
I
Q
V
D
-----
I
G
GGQT
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
R
----
E
G
----
E
K
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
G
V
F
E
V
V
-
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
-
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
--
S
S
Q
H
Q
A
--
R
I
E
I
E
S
F
Y
E
G
E
D
----
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
--
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
73.59
49%
-79
- C3 -
3KVG
4
?
B:
[19-400]
-
G
P
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
----
W
----
R
----
N
DTVD
I
V
P
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
E
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
R
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
K
F
D
D
Q
----
A
V
-
Q
-
S
DM
T
--
H
-
W
-
P
F
K
V
V
R
G
P
K
D
K
-
P
I
--
I
S
V
N
YLG--
E
K
----
K
E
F
H
A
E
E
I
S
A
M
V
L
Q
K
M
K
E
I
S
E
A
Y
L
G
R
Q
I
K
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
G
T
GE--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
E
D
G
I
F
E
V
K
-
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
E
F
C
V
Q
D
F
K
R
K
N
R
G
M
D
L
T
T
N
A
R
A
L
R
R
L
R
T
Q
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
T
I
E
L
D
S
L
Y
E
G
I
D
----
Y
S
V
A
I
S
R
A
R
F
E
E
L
C
A
D
Y
F
-
R
A
T
L
A
P
V
E
K
V
L
K
D
--
A
G
M
D
K
R
S
V
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
A
L
I
Q
E
F
F
N
G
-
K
E
P
C
K
A
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
N
G
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
73.32
52%
-80
- C3 -
3QFU
3
GRP78_YEAST
A:
[18-393]
-
G
T
V
I
G
I
D
L
G
T
T
Y
S
C
V
A
V
----
M
K
N--
G
----
K
T
E
--
I
L
A
N
E
Q
G
N
R
I
T
P
S
Y
V
A
F
T
D
D
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
A
N
P
Q
N
T
I
F
D
I
K
R
L
I
G
L
K
Y
N
D
R
----
S
V
Q
K
-
D
--
I
K
-
H
-
L
-
P
F
N
V
-
V
N
K
D
G
K
-
P
A
--
V
E
V
S
V
KG--
E
K
----
K
V
F
T
P
E
E
I
S
G
M
I
L
G
K
M
K
Q
I
A
E
D
Y
L
G
T
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
V
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
S
----
D
K
E
---
H
-
Q
I
I
V
Y
D
L
G
G
G
T
F
D
V
S
L
L
S
I
----
E
N
G
V
F
E
V
Q
-
A
T
S
G
D
T
H
L
G
G
E
D
F
D
Y
K
I
V
R
Q
L
I
K
A
F
K
K
K
H
-
G
I
D
V
S
D
N
N
K
A
L
A
K
L
K
R
E
A
E
K
A
K
R
A
L
--
S
S
Q
M
S
T
--
R
I
E
I
D
S
F
V
D
G
I
D
----
L
S
E
T
L
T
R
A
K
F
E
E
L
N
L
D
L
F
-
K
K
T
L
K
P
V
E
K
V
L
Q
D
--
S
G
L
E
K
K
D
V
D
D
I
V
L
V
G
G
S
T
R
I
P
K
V
Q
Q
L
L
E
S
Y
F
D
G
-
K
K
A
S
K
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
73.25
52%
-80
- C3 -
3LDO
1
GRP78_HUMAN
A:
[4-384]
V
G
T
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
NG
R
----
V
----
E
----
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
T
W
N
D
P
----
S
V
-
Q
Q
D
--
I
--
K
F
L
-
P
F
K
V
V
E
K
K
T
-
K
-
P
Y
--
I
Q
V
D
-----
I
G
GG
Q
T
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
R
----
E
G
----
E
K
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
G
V
F
E
V
V
-
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
-
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
--
S
S
Q
H
Q
A
--
R
I
E
I
E
S
F
Y
E
G
E
D
----
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
--
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
73.05
50%
-82
- C3 -
3FE1
2
HSP76_HUMAN
A:
[23-403]
M
E
L
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
Q
----
G
----
R
V
E
--
I
L
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
V
G
D
A
A
K
S
Q
A
A
L
N
P
H
N
T
V
F
D
A
K
R
L
I
G
R
K
F
A
D
T
----
T
V
-
Q
S
D
--
M
K
-
H
-
W
-
P
F
R
V
-
V
S
E
G
G
K
-
P
K
--
V
R
V
C
Y
RG--
E
D
----
K
T
F
Y
P
E
E
I
S
S
M
V
L
S
K
M
K
E
T
A
E
A
Y
L
G
Q
P
V
K
H
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
--
R
----
G
A
G
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
V
L
S
I
----
D
A
G
V
F
E
V
K
-
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
M
E
E
F
R
R
K
H
-
G
K
D
L
S
G
N
K
R
A
L
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
T
L
E
I
D
S
L
F
E
G
V
D
------
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
--
A
K
L
D
K
A
Q
I
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
V
L
M
G
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
72.95
50%
-80
- C3 -
3FE1
4
HSP76_HUMAN
B:
[23-403]
M
E
L
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
Q
----
G
----
R
V
E
--
I
L
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
V
G
D
A
A
K
S
Q
A
A
L
N
P
H
N
T
V
F
D
A
K
R
L
I
G
R
K
F
A
D
T
----
T
V
-
Q
S
D
--
M
K
-
H
-
W
-
P
F
R
V
-
V
S
E
G
G
K
-
P
K
--
V
R
V
C
Y
RG--
E
D
----
K
T
F
Y
P
E
E
I
S
S
M
V
L
S
K
M
K
E
T
A
E
A
Y
L
G
Q
P
V
K
H
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
--
R
----
G
A
G
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
V
L
S
I
----
D
A
G
V
F
E
V
K
-
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
M
E
E
F
R
R
K
H
-
G
K
D
L
S
G
N
K
R
A
L
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
T
L
E
I
D
S
L
F
E
G
V
D
------
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
--
A
K
L
D
K
A
Q
I
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
V
L
M
G
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
72.91
52%
-87
- C3 -
3A8Y
1
HS71A_HUMAN
A:
[10-387]
---
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
V
E
--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
-
K
-------
H
-
W
-
P
F
Q
V
I
--
N
D
G
D
K
P
K
--
V
Q
V
S
Y
KG--
E
T
----
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
TG
K
----
G
E
----
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
K
-
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
-
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
I
D
------
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
--
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
72.73
52%
-83
- C3 -
3A8Y
1
HS71A_HUMAN
B:
[10-385]
---
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
V
E
--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
-
K
-------
H
-
W
-
P
F
Q
V
I
--
N
D
G
D
K
P
K
--
V
Q
V
S
Y
KG--
E
T
----
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
TG------
E
----
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
K
-
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
-
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
I
D
------
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
--
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
72.55
51%
-84
- C3 -
1S3X
5
HS71A_HUMAN
A:
[6-382]
---
A
I
G
I
D
L
G
T
T
Y
S
C
I
G
V
F
Q
--
H
----
G
----
K
V
E
--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
-
K
-------
H
-
W
-
P
F
Q
V
I
--
N
D
G
D
K
P
K
--
V
Q
V
S
Y
KG--
E
T
----
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
TG
K
----
G
E
----
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
K
-
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
-
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
I
D
------
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
--
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
72.51
52%
-78
- C3 -
3LDP
1
GRP78_HUMAN
B:
[4-383]
V
G
T
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
FKNG
R
----
V
----
E
----
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
T
W
N
D
P
----
S
V
-
Q
Q
D
--
I
--
K
F
L
-
P
F
K
V
V
E
K
K
T
-
K
-
P
Y
--
I
Q
V
D
-----
I
G
GGQT
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
R
----
E
G
----
E
K
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
G
V
F
E
V
V
-
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
-
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
--
S
S
Q
H
Q
A
--
R
I
E
I
E
S
F
Y
E
G
E
D
----
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
--
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
72.46
52%
-83
- C3 -
3AY9
5
HS71A_HUMAN
A:
[10-386]
---
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
V
E
--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
-
K
-------
H
-
W
-
P
F
Q
V
I
--
N
D
G
D
K
P
K
--
V
Q
V
S
Y
KG--
E
T
----
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
TG
K
----
G
E
----
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
K
-
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
-
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
I
D
------
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
--
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
72.38
51%
-82
- C3 -
3I33
3
HSP72_HUMAN
A:
[25-402]
---
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
V
E
--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
I
F
D
A
K
R
L
I
G
R
K
F
E
D
A
----
T
V
-
Q
S
D
--
M
K
-
H
-
W
-
P
F
R
V
-
V
S
E
G
G
K
-
P
K
--
V
Q
V
E
Y
KG--
E
T
----
K
T
F
F
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
G
K
V
H
S
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
T
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
G
C
AGGE
K
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
S
H
L
A
E
E
F
K
R
K
H
-
K
K
D
I
G
P
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
V
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
E
P
V
E
K
A
L
R
D
--
A
K
L
D
K
G
Q
I
Q
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
72.28
52%
-84
- C3 -
3JXU
2
HS71A_HUMAN
A:
[28-403]
---
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
-
K
-------
H
-
W
-
P
F
Q
V
I
--
N
D
G
D
K
P
K
--
V
Q
V
S
Y
KG--
E
T
----
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
TG
K
----
G
E
----
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
K
-
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
-
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
I
D
------
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
--
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
HHSearch
72.25
54%
-77
- C3 -
3QFU
3
GRP78_YEAST
A:
[18-393]
-
G
T
V
I
G
I
D
L
G
T
T
Y
S
C
V
A
V
M
K
NG
K
----
T
----
E
----
I
L
A
N
E
Q
G
N
R
I
T
P
S
Y
V
A
F
T
D
-
D
E
R
L
I
G
D
A
A
K
N
Q
V
A
A
N
P
Q
N
T
I
F
D
I
K
R
L
I
G
L
K
Y
N
D
R
S
V
--
Q
K
-
D
-
I
--
K
--
H
-
L
-
P
F
N
V
V
N
K
-
D
G
K
-
P
A
V
E
V
S
V
K
G----
E
K
----
K
V
F
T
P
E
E
I
S
G
M
I
L
G
K
M
K
Q
I
A
E
D
Y
L
G
T
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
V
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
S
D---
K
E
----
H
-
Q
I
I
V
Y
D
L
G
G
G
T
F
D
V
S
L
L
S
I
----
E
N
G
V
F
E
V
Q
-
A
T
S
G
D
T
H
L
G
G
E
D
F
D
Y
K
I
V
R
Q
L
I
K
A
F
K
K
K
H
-
G
I
D
V
S
D
N
N
K
A
L
A
K
L
K
R
E
A
E
K
A
K
R
A
L
--
S
S
Q
M
S
T
--
R
I
E
I
D
S
F
V
D
----
G
I
D
L
S
E
T
L
T
R
A
K
F
E
E
L
N
L
D
L
F
-
K
K
T
L
K
P
V
E
K
V
L
Q
D
--
S
G
L
E
K
K
D
V
D
D
I
V
L
V
G
G
S
T
R
I
P
K
V
Q
Q
L
L
E
S
Y
F
-
D
G
K
K
A
S
K
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
72.17
52%
-84
- C3 -
2E8A
2
HS71A_HUMAN
A:
[9-385]
---
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
-
K
-------
H
-
W
-
P
F
Q
V
I
--
N
D
G
D
K
P
K
--
V
Q
V
S
Y
KG--
E
T
----
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
TG
K
----
G
E
----
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
K
-
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
-
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
I
D
------
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
--
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
72.03
52%
-82
- C3 -
3ATU
4
HS71A_HUMAN
A:
[10-386]
---
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
V
E
--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
-
K
-------
H
-
W
-
P
F
Q
V
I
--
N
D
G
D
K
P
K
--
V
Q
V
S
Y
KG--
E
T
----
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
TG
K
----
G
E
----
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
K
-
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
-
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
I
D
------
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
--
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
72.00
49%
-86
- C3 -
3LDQ
1
HSP7C_HUMAN
A:
[5-380]
--
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
71.59
49%
-83
- C3 -
3FZK
3
HSP7C_HUMAN
A:
[5-380]
--
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
FQ--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
71.57
49%
-84
- C3 -
3FZH
1
HSP7C_HUMAN
A:
[5-380]
--
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
71.57
49%
-83
- C3 -
3FZM
1
HSP7C_HUMAN
A:
[5-380]
--
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
FQ--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
EYKG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
71.51
52%
-82
- C3 -
3ATV
3
HS71A_HUMAN
A:
[10-386]
---
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
V
E
--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
-
K
-------
H
-
W
-
P
F
Q
V
I
--
N
D
G
D
K
P
K
--
V
Q
V
S
Y
KG--
E
T
----
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
TG
K
----
G
E
----
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
K
-
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
-
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
G
I
D
------
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
--
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
71.50
49%
-77
- C3 -
2QWQ
5
HSP7C_BOVIN
A:
[4-386]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
FQ--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
KSE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
71.45
49%
-78
- C3 -
2QWR
4
HSP7C_BOVIN
A:
[4-386]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
KSE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
71.42
49%
-77
- C3 -
1NGF
1
HSP7C_BOVIN
A:
[4-383]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
N
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
----
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
71.35
49%
-79
- C3 -
1ATS
2
HSP7C_BOVIN
A:
[4-383]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
FQ--
H
----
G
----
K
V
E
--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
E
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
71.18
49%
-83
- C3 -
3FZF
1
HSP7C_HUMAN
A:
[5-380]
--
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
V
E
--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
71.10
49%
-78
- C3 -
1NGH
1
HSP7C_BOVIN
A:
[4-381]
-
G
P
A
V
G
I
N
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
V
E
--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
71.00
50%
-78
- C3 -
4H5T
3
HSP7C_HUMAN
A:
[3-382]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
----
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
70.95
49%
-78
- C3 -
1NGG
1
HSP7C_BOVIN
A:
[4-381]
-
G
P
A
V
G
I
S
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
V
E
--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
70.85
50%
-79
- C3 -
1HPM
6
HSP7C_BOVIN
A:
[4-381]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
70.82
49%
-79
- C3 -
2QWP
7
HSP7C_BOVIN
A:
[4-389]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
KSEN
V
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
70.75
49%
-77
- C3 -
1NGB
2
HSP7C_BOVIN
A:
[4-381]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
Q
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
HHSearch
70.74
52%
-77
- C3 -
3I33
3
HSP72_HUMAN
A:
[23-402]
-
M
P
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
HG
K
----
V
----
E
----
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
-
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
I
F
D
A
K
R
L
I
G
R
K
F
E
D
A
T
V
--
Q
S
-
D
-
M
--
K
--
H
-
W
-
P
F
R
V
V
S
E
-
G
G
K
-
P
K
--
V
Q
V
E
Y
KG--
E
T
----
K
T
F
F
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
G
K
V
H
S
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
T
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
GCAG
G
E
----
K
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
S
H
L
A
E
E
F
K
R
K
H
-
K
K
D
I
G
P
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
----
G
V
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
E
P
V
E
K
A
L
R
D
--
A
K
L
D
K
G
Q
I
Q
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
-
N
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
70.73
49%
-79
- C3 -
1NGE
1
HSP7C_BOVIN
A:
[4-381]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
S
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
70.70
50%
-78
- C3 -
1NGI
2
HSP7C_BOVIN
A:
[4-381]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
70.67
50%
-76
- C3 -
3HSC
5
HSP7C_BOVIN
A:
[4-383]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
----
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
70.65
49%
-77
- C3 -
1BUP
6
HSP7C_BOVIN
A:
[4-381]
-
G
P
A
V
G
I
D
L
G
S
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
70.54
49%
-83
- C3 -
1HX1
1
HSP7C_BOVIN
A:
[24-399]
--
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
70.51
49%
-78
- C3 -
1NGD
3
HSP7C_BOVIN
A:
[4-381]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
N
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
70.44
49%
-81
- C3 -
3FZL
2
HSP7C_HUMAN
A:
[5-380]
--
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
70.38
49%
-77
- C3 -
1NGC
2
HSP7C_BOVIN
A:
[4-381]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
V
E
--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
S
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
70.34
50%
-79
- C3 -
3GDQ
3
HS71L_HUMAN
A:
[28-406]
-
G
I
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
N
D
P
----
V
V
-
Q
A
D
--
M
--
K
-
L
W
P
F
Q
V
I
N
E
G
G
K
P
-
K
V
--
L
V
S
Y
-----
K
G
E
N
--
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
L
K
E
T
A
E
A
F
L
G
H
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
G
E
R
----
H
--------
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
K
-
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
S
H
F
V
E
E
F
K
R
K
H
-
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
N
L
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
A
D
L
F
-
R
G
T
L
E
P
V
E
K
A
L
R
D
--
A
K
M
D
K
A
K
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
V
Q
R
L
L
Q
D
Y
F
N
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
70.31
50%
-78
- C3 -
1NGJ
2
HSP7C_BOVIN
A:
[4-383]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
V
E
--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
----
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
70.30
49%
-75
- C3 -
1ATR
3
HSP7C_BOVIN
A:
[4-383]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
V
E
--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
V
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
----
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
70.26
49%
-80
- C3 -
2BUP
6
HSP7C_BOVIN
A:
[4-380]
-
G
P
A
V
G
I
D
L
G
G
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
70.26
49%
-80
- C3 -
3M3Z
1
HSP7C_HUMAN
A:
[5-380]
--
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
FQ--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
70.21
50%
-75
- C3 -
4H5W
5
HSP7C_HUMAN
A:
[3-382]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
----
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
69.90
49%
-78
- C3 -
1NGA
2
HSP7C_BOVIN
A:
[4-381]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
S
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
69.85
50%
-75
- C3 -
4H5R
10
HSP7C_HUMAN
A:
[3-382]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
V
E
--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
----
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
69.75
49%
-75
- C3 -
2QWO
7
HSP7C_BOVIN
A:
[4-390]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
KSEN
V
Q
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
69.71
49%
-75
- C3 -
2QWM
5
HSP7C_BOVIN
B:
[4-384]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
FQ--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
VEYKG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
AE--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
69.68
49%
-77
- C3 -
1BA1
4
HSP7C_BOVIN
A:
[4-381]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
K
V
G
V
F
Q
--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
69.65
49%
-76
- C3 -
2QWL
4
HSP7C_BOVIN
B:
[4-384]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
FQ--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
VEYKG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
AE--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
69.56
49%
-80
- C3 -
1KAZ
6
HSP7C_BOVIN
A:
[4-380]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
E
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
69.52
50%
-74
- C3 -
4H5V
9
HSP7C_HUMAN
A:
[3-382]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
----
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
69.44
50%
-75
- C3 -
4H5R
8
HSP7C_HUMAN
B:
[3-382]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
FQ--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
VEYKG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
AE--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
----
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
69.36
50%
-73
- C3 -
4H5N
9
HSP7C_HUMAN
A:
[3-382]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
----
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
69.36
49%
-77
- C3 -
2QWN
5
HSP7C_BOVIN
A:
[4-385]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
KS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
69.35
49%
-79
- C3 -
1KAY
6
HSP7C_BOVIN
A:
[4-380]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
A
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
69.23
49%
-78
- C3 -
1BA0
5
HSP7C_BOVIN
A:
[4-381]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
K
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
69.15
50%
-76
- C3 -
4H5W
4
HSP7C_HUMAN
B:
[3-382]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
FQ--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
VEYKG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
AE--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
----
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
68.83
49%
-79
- C3 -
1KAX
6
HSP7C_BOVIN
A:
[4-380]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
M
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
68.75
49%
-75
- C3 -
2QWM
5
HSP7C_BOVIN
A:
[4-384]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
VE--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
68.45
49%
-76
- C3 -
2QWL
4
HSP7C_BOVIN
A:
[4-384]
-
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
--
H
----
G
----
K
V
E
--
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
D
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
----
V
V
-
Q
-
S
-----
D
-
M
-
K
H
W
P
F
M
V
V
N
D
A
-
G
R
--
P
K
V
Q
V
E
Y
KG
E
T
----
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
--
K
----
V
G
A
E
--
R
-
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
--
S
S
S
T
Q
A
--
S
I
E
I
D
S
L
Y
E
G
I
D
----
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
--
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------