@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0519: (2015-12-02 )
MSVLVGKDTRLICQGFTGAQGTFHSEQAISYGTKMVGGVTPGKGGSSHLNLPVFNTVAEAKEKTDANATVIYVPAKFAAAAILEAIDAEIELIVCITEGIPILDMVRVKHALISSKSRLIGPNCPGIITPEECKIGIMPGHIHKRGHIGIMSRSGTLTYEAVAQTTAVGPGQSTCIGIGGDPIHGMTFVDCMELFLKDEDTHGIVVIGEIGGNEEEDVSHFVKTEKTKKPIVGFIAGQTAPPGRRMGHAGAIISSSGGSAGAKLEVMSSAGIAIAETPAMIGKKILEVMHKAHVA
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........90........100.......110...-....120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.....---..230.......240.......250.......260.......270.......280.......290...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
S
V
L
VGKD
T
R
L
I
C
QGFTGAQGTFH
S
E
Q
A
I
S
YGTKMVGGVTPGKGGSSHLNL
P
V
F
N
T
V
A
E
A
KEKTDAN
A
T
V
I
Y
V
P
A
K
F
A
A
A
A
I
L
E
A
IDAE
I
E
L
I
V
C
ITEGI
P
I
L
D
M
V
R
V
K
H
A
L
I
SS-KSRLIGPNCPGII
T
P
E
E
C
K
I
GIMPGHIHKRGH
I
G
I
M
SRSG
T
L
T
Y
E
AVAQTTAVGPGQ
S
T
C
I
GIGGDPIHG
M
T
F
V
D
C
M
E
L
F
LKDEDTH
G
I
V
V
I
G
EIGGN
E
E
E
D
V
S
H
F
V
K
TEKT---KK
P
I
V
G
F
IAGQTAPPGRRMGHA
G
A
I
I
SSSGGSAG
A
K
L
E
V
M
SSAG
I
A
I
AE
T
P
A
M
I
G
K
K
I
L
E
V
M
H
K
AHVA
10
PsiBlast_PDB
97.00
64%
-113
- C4 -
4XX0
7
?
A:
[9-301]
--
L
Y
V
D
K
N
T
K
V
I
C
Q
G
F
T
G
K
Q
G
T
F
H
S
Q
Q
A
L
E
Y
G
T
N
L
V
G
G
T
T
P
G
K
G
G
K
T
H
L
G
L
P
V
F
N
T
V
K
E
A
K
E
Q
T
G
A
T
A
S
V
I
Y
V
P
P
P
F
A
A
A
A
I
N
E
A
I
D
A
E
V
P
L
V
V
C
I
T
E
G
I
P
Q
Q
D
M
V
R
V
K
H
R
L
L
R
Q
G
K
T
R
L
I
G
P
N
C
P
G
V
I
N
P
G
E
C
K
I
G
I
M
P
G
H
I
H
K
K
G
R
I
G
I
V
S
R
S
G
T
L
T
Y
E
A
V
H
Q
T
T
Q
V
G
L
G
Q
S
L
C
V
G
I
G
G
D
P
F
N
G
T
D
F
T
D
C
L
E
I
F
L
N
D
P
A
T
E
G
I
I
L
I
G
E
I
G
G
N
A
E
E
N
A
A
E
F
L
K
Q
H
N
S
GPK
S
K
P
V
V
S
F
I
A
G
L
T
A
P
P
G
R
R
M
G
H
A
G
A
I
I
A
G
G
K
G
G
A
K
E
K
I
T
A
L
Q
S
A
G
V
V
V
S
M
S
P
A
Q
L
G
T
T
I
Y
K
E
F
E
K
R
K
--
9
PsiBlast_PDB
96.75
64%
-111
- C4 -
1EUC
2
SUCA_PIG
A:
[15-307]
--
L
Y
V
D
K
N
T
K
V
I
C
Q
G
F
T
G
K
Q
G
T
F
H
S
Q
Q
A
L
E
Y
G
T
N
L
V
G
G
T
T
P
G
K
G
G
K
T
H
L
G
L
P
V
F
N
T
V
K
E
A
K
E
Q
T
G
A
T
A
S
V
I
Y
V
P
P
P
F
A
A
A
A
I
N
E
A
I
D
A
E
V
P
L
V
V
C
I
T
E
G
I
P
Q
Q
D
M
V
R
V
K
H
R
L
L
R
Q
G
K
T
R
L
I
G
P
N
C
P
G
V
I
N
P
G
E
C
K
I
G
I
M
P
G
H
I
H
K
K
G
R
I
G
I
V
S
R
S
G
T
L
T
Y
E
A
V
H
Q
T
T
Q
V
G
L
G
Q
S
L
C
V
G
I
G
G
D
P
F
N
G
T
D
F
T
D
C
L
E
I
F
L
N
D
P
A
T
E
G
I
I
L
I
G
E
I
G
G
N
A
E
E
N
A
A
E
F
L
K
Q
H
N
S
GPK
S
K
P
V
V
S
F
I
A
G
L
T
A
P
P
G
R
R
M
G
H
A
G
A
I
I
A
G
G
K
G
G
A
K
E
K
I
T
A
L
Q
S
A
G
V
V
V
S
M
S
P
A
Q
L
G
T
T
I
Y
K
E
F
E
K
R
K
M
L
8
PsiBlast_PDB
95.11
64%
-109
- C4 -
2FPG
1
SUCA_PIG
A:
[9-301]
--
L
Y
V
D
K
N
T
K
V
I
C
Q
G
F
T
G
K
Q
G
T
F
H
S
Q
Q
A
L
E
Y
G
T
N
L
V
G
G
T
T
P
G
K
G
G
K
T
H
L
G
L
P
V
F
N
T
V
K
E
A
K
E
Q
T
G
A
T
A
S
V
I
Y
V
P
P
P
F
A
A
A
A
I
N
E
A
I
D
A
E
V
P
L
V
V
C
I
T
E
G
I
P
Q
Q
D
M
V
R
V
K
H
R
L
L
R
Q
G
K
T
R
L
I
G
P
N
C
P
G
V
I
N
P
G
E
C
K
I
G
I
M
P
G
H
I
H
K
K
G
R
I
G
I
V
S
R
S
G
T
L
T
Y
E
A
V
H
Q
T
T
Q
V
G
L
G
Q
S
L
C
V
G
I
G
G
D
P
F
N
G
T
D
F
T
D
C
L
E
I
F
L
N
D
P
A
T
E
G
I
I
L
I
G
E
I
G
G
N
A
E
E
N
A
A
E
F
L
K
Q
H
N
S
GPK
S
K
P
V
V
S
F
I
A
G
L
T
A
P
P
G
R
R
M
G
H
A
G
A
I
I
A
G
G
K
G
G
A
K
E
K
I
T
A
L
Q
S
A
G
V
V
V
S
M
S
P
A
Q
L
G
T
T
I
Y
K
E
F
E
K
R
K
M
L
7
PsiBlast_PDB
94.31
62%
-114
- C4 -
2NU8
4
SUCD_ECOLI
A:
[1-287]
-
S
I
L
I
D
K
N
T
K
V
I
C
Q
G
F
T
G
S
Q
G
T
F
H
S
E
Q
A
I
A
Y
G
T
K
M
V
G
G
V
T
P
G
K
G
G
T
T
H
L
G
L
P
V
F
N
T
V
R
E
A
V
A
A
T
G
A
T
A
S
V
I
Y
V
P
A
P
F
C
K
D
S
I
L
E
A
I
D
A
G
I
K
L
I
I
T
I
T
E
G
I
P
T
L
D
M
L
T
V
K
V
K
L
D
E
A
-
G
V
R
M
I
G
P
N
T
P
G
V
I
T
P
G
E
C
K
I
G
I
Q
P
G
H
I
H
K
P
G
K
V
G
I
V
S
R
S
G
T
L
T
Y
E
A
V
K
Q
T
T
D
Y
G
F
G
Q
S
T
C
V
G
I
G
G
D
P
I
P
G
S
N
F
I
D
I
L
E
M
F
E
K
D
P
Q
T
E
A
I
V
M
I
G
E
I
G
G
S
A
E
E
E
A
A
A
Y
I
K
-
E
H
V
---
T
K
P
V
V
G
Y
I
A
G
V
T
A
P
K
G
K
R
M
G
H
A
G
A
I
I
A
G
G
K
G
T
A
D
E
K
F
A
A
L
E
A
A
G
V
K
T
V
R
S
L
A
D
I
G
E
A
L
K
T
V
L
------
27
PsiBlast_CBE
93.82
62%
-115
- C4 -
2NU7
4
SUCD_ECOLI
D:
[1-287]
-
S
I
L
I
D
K
N
T
K
V
I
C
Q
G
F
T
G
S
Q
G
T
F
H
S
E
Q
A
I
A
Y
G
T
K
M
V
G
G
V
T
P
G
K
G
G
T
T
H
L
G
L
P
V
F
N
T
V
R
E
A
V
A
A
T
G
A
T
A
S
V
I
Y
V
P
A
P
F
C
K
D
S
I
L
E
A
I
D
A
G
I
K
L
I
I
T
I
T
E
G
I
P
T
L
D
M
L
T
V
K
V
K
L
D
E
A
-
G
V
R
M
I
G
P
N
S
P
G
V
I
T
P
G
E
C
K
I
G
I
Q
P
G
H
I
H
K
P
G
K
V
G
I
V
S
R
S
G
T
L
T
Y
E
A
V
K
Q
T
T
D
Y
G
F
G
Q
S
T
C
V
G
I
G
G
D
P
I
P
G
S
N
F
I
D
I
L
E
M
F
E
K
D
P
Q
T
E
A
I
V
M
I
G
E
I
G
G
S
A
E
E
E
A
A
A
Y
I
K
-
E
H
V
---
T
K
P
V
V
G
Y
I
A
G
V
T
A
P
K
G
K
R
M
G
H
A
G
A
I
I
A
G
G
K
G
T
A
D
E
K
F
A
A
L
E
A
A
G
V
K
T
V
R
S
L
A
D
I
G
E
A
L
K
T
V
L
------
23
PsiBlast_CBE
93.70
62%
-113
- C4 -
1JKJ
3
SUCD_ECOLI
D:
[1-287]
-
S
I
L
I
D
K
N
T
K
V
I
C
Q
G
F
T
G
S
Q
G
T
F
H
S
E
Q
A
I
A
Y
G
T
K
M
V
G
G
V
T
P
G
K
G
G
T
T
H
L
G
L
P
V
F
N
T
V
R
E
A
V
A
A
T
G
A
T
A
S
V
I
Y
V
P
A
P
F
C
K
D
S
I
L
E
A
I
D
A
G
I
K
L
I
I
T
I
T
E
G
I
P
T
L
D
M
L
T
V
K
V
K
L
D
E
A
-
G
V
R
M
I
G
P
N
C
P
G
V
I
T
P
G
E
C
K
I
G
I
Q
P
G
H
I
H
K
P
G
K
V
G
I
V
S
R
S
G
T
L
T
Y
E
A
V
K
Q
T
T
D
Y
G
F
G
Q
S
T
C
V
G
I
G
G
D
P
I
P
G
S
N
F
I
D
I
L
E
M
F
E
K
D
P
Q
T
E
A
I
V
M
I
G
E
I
G
G
S
A
E
E
E
A
A
A
Y
I
K
-
E
H
V
---
T
K
P
V
V
G
Y
I
A
G
V
T
A
P
K
G
K
R
M
G
H
A
G
A
I
I
A
G
G
K
G
T
A
D
E
K
F
A
A
L
E
A
A
G
V
K
T
V
R
S
L
A
D
I
G
E
A
L
K
T
V
L
------
1
PsiBlast_PDB
93.67
62%
-112
- C4 -
1JKJ
6
SUCD_ECOLI
A:
[1-287]
-
S
I
L
I
D
K
N
T
K
V
I
C
Q
G
F
T
G
S
Q
G
T
F
H
S
E
Q
A
I
A
Y
G
T
K
M
V
G
G
V
T
P
G
K
G
G
T
T
H
L
G
L
P
V
F
N
T
V
R
E
A
V
A
A
T
G
A
T
A
S
V
I
Y
V
P
A
P
F
C
K
D
S
I
L
E
A
I
D
A
G
I
K
L
I
I
T
I
T
E
G
I
P
T
L
D
M
L
T
V
K
V
K
L
D
E
A
-
G
V
R
M
I
G
P
N
C
P
G
V
I
T
P
G
E
C
K
I
G
I
Q
P
G
H
I
H
K
P
G
K
V
G
I
V
S
R
S
G
T
L
T
Y
E
A
V
K
Q
T
T
D
Y
G
F
G
Q
S
T
C
V
G
I
G
G
D
P
I
P
G
S
N
F
I
D
I
L
E
M
F
E
K
D
P
Q
T
E
A
I
V
M
I
G
E
I
G
G
S
A
E
E
E
A
A
A
Y
I
K
-
E
H
V
---
T
K
P
V
V
G
Y
I
A
G
V
T
A
P
K
G
K
R
M
G
H
A
G
A
I
I
A
G
G
K
G
T
A
D
E
K
F
A
A
L
E
A
A
G
V
K
T
V
R
S
L
A
D
I
G
E
A
L
K
T
V
L
------
6
PsiBlast_PDB
93.63
62%
-116
- C4 -
2NU7
4
SUCD_ECOLI
A:
[1-287]
-
S
I
L
I
D
K
N
T
K
V
I
C
Q
G
F
T
G
S
Q
G
T
F
H
S
E
Q
A
I
A
Y
G
T
K
M
V
G
G
V
T
P
G
K
G
G
T
T
H
L
G
L
P
V
F
N
T
V
R
E
A
V
A
A
T
G
A
T
A
S
V
I
Y
V
P
A
P
F
C
K
D
S
I
L
E
A
I
D
A
G
I
K
L
I
I
T
I
T
E
G
I
P
T
L
D
M
L
T
V
K
V
K
L
D
E
A
-
G
V
R
M
I
G
P
N
S
P
G
V
I
T
P
G
E
C
K
I
G
I
Q
P
G
H
I
H
K
P
G
K
V
G
I
V
S
R
S
G
T
L
T
Y
E
A
V
K
Q
T
T
D
Y
G
F
G
Q
S
T
C
V
G
I
G
G
D
P
I
P
G
S
N
F
I
D
I
L
E
M
F
E
K
D
P
Q
T
E
A
I
V
M
I
G
E
I
G
G
S
A
E
E
E
A
A
A
Y
I
K
-
E
H
V
---
T
K
P
V
V
G
Y
I
A
G
V
T
A
P
K
G
K
R
M
G
H
A
G
A
I
I
A
G
G
K
G
T
A
D
E
K
F
A
A
L
E
A
A
G
V
K
T
V
R
S
L
A
D
I
G
E
A
L
K
T
V
L
------
22
PsiBlast_CBE
93.61
62%
-112
- C4 -
1JLL
3
SUCD_ECOLI
D:
[1-287]
-
S
I
L
I
D
K
N
T
K
V
I
C
Q
G
F
T
G
S
Q
G
T
F
H
S
E
Q
A
I
A
Y
G
T
K
M
V
G
G
V
T
P
G
K
G
G
T
T
H
L
G
L
P
V
F
N
T
V
R
E
A
V
A
A
T
G
A
T
A
S
V
I
Y
V
P
A
P
F
C
K
D
S
I
L
E
A
I
D
A
G
I
K
L
I
I
T
I
T
E
G
I
P
T
L
D
M
L
T
V
K
V
K
L
D
E
A
-
G
V
R
M
I
G
P
N
C
P
G
V
I
T
P
G
E
C
K
I
G
I
Q
P
G
H
I
H
K
P
G
K
V
G
I
V
S
R
S
G
T
L
T
Y
E
A
V
K
Q
T
T
D
Y
G
F
G
Q
S
T
C
V
G
I
G
G
D
P
I
P
G
S
N
F
I
D
I
L
E
M
F
E
K
D
P
Q
T
E
A
I
V
M
I
G
E
I
G
G
S
A
E
E
E
A
A
A
Y
I
K
-
E
H
V
---
T
K
P
V
V
G
Y
I
A
G
V
T
A
P
K
G
K
R
M
G
H
A
G
A
I
I
A
G
G
K
G
T
A
D
E
K
F
A
A
L
E
A
A
G
V
K
T
V
R
S
L
A
D
I
G
E
A
L
K
T
V
L
------
28
PsiBlast_CBE
93.45
62%
-115
- C4 -
2NU8
3
SUCD_ECOLI
D:
[1-287]
-
S
I
L
I
D
K
N
T
K
V
I
C
Q
G
F
T
G
S
Q
G
T
F
H
S
E
Q
A
I
A
Y
G
T
K
M
V
G
G
V
T
P
G
K
G
G
T
T
H
L
G
L
P
V
F
N
T
V
R
E
A
V
A
A
T
G
A
T
A
S
V
I
Y
V
P
A
P
F
C
K
D
S
I
L
E
A
I
D
A
G
I
K
L
I
I
T
I
T
E
G
I
P
T
L
D
M
L
T
V
K
V
K
L
D
E
A
-
G
V
R
M
I
G
P
N
T
P
G
V
I
T
P
G
E
C
K
I
G
I
Q
P
G
H
I
H
K
P
G
K
V
G
I
V
S
R
S
G
T
L
T
Y
E
A
V
K
Q
T
T
D
Y
G
F
G
Q
S
T
C
V
G
I
G
G
D
P
I
P
G
S
N
F
I
D
I
L
E
M
F
E
K
D
P
Q
T
E
A
I
V
M
I
G
E
I
G
G
S
A
E
E
E
A
A
A
Y
I
K
-
E
H
V
---
T
K
P
V
V
G
Y
I
A
G
V
T
A
P
K
G
K
R
M
G
H
A
G
A
I
I
A
G
G
K
G
T
A
D
E
K
F
A
A
L
E
A
A
G
V
K
T
V
R
S
L
A
D
I
G
E
A
L
K
T
V
L
------
5
PsiBlast_PDB
93.29
62%
-117
- C4 -
2NUA
4
SUCD_ECOLI
A:
[1-287]
-
S
I
L
I
D
K
N
T
K
V
I
C
Q
G
F
T
G
S
Q
G
T
F
H
S
E
Q
A
I
A
Y
G
T
K
M
V
G
G
V
T
P
G
K
G
G
T
T
H
L
G
L
P
V
F
N
T
V
R
E
A
V
A
A
T
G
A
T
A
S
V
I
Y
V
P
A
P
F
C
K
D
S
I
L
E
A
I
D
A
G
I
K
L
I
I
T
I
T
E
G
I
P
T
L
D
M
L
T
V
K
V
K
L
D
E
A
-
G
V
R
M
I
G
P
N
V
P
G
V
I
T
P
G
E
C
K
I
G
I
Q
P
G
H
I
H
K
P
G
K
V
G
I
V
S
R
S
G
T
L
T
Y
E
A
V
K
Q
T
T
D
Y
G
F
G
Q
S
T
C
V
G
I
G
G
D
P
I
P
G
S
N
F
I
D
I
L
E
M
F
E
K
D
P
Q
T
E
A
I
V
M
I
G
E
I
G
G
S
A
E
E
E
A
A
A
Y
I
K
-
E
H
V
---
T
K
P
V
V
G
Y
I
A
G
V
T
A
P
K
G
K
R
M
G
H
A
G
A
I
I
A
G
G
K
G
T
A
D
E
K
F
A
A
L
E
A
A
G
V
K
T
V
R
S
L
A
D
I
G
E
A
L
K
T
V
L
------
2
PsiBlast_PDB
93.18
62%
-113
- C4 -
1JLL
3
SUCD_ECOLI
A:
[1-287]
-
S
I
L
I
D
K
N
T
K
V
I
C
Q
G
F
T
G
S
Q
G
T
F
H
S
E
Q
A
I
A
Y
G
T
K
M
V
G
G
V
T
P
G
K
G
G
T
T
H
L
G
L
P
V
F
N
T
V
R
E
A
V
A
A
T
G
A
T
A
S
V
I
Y
V
P
A
P
F
C
K
D
S
I
L
E
A
I
D
A
G
I
K
L
I
I
T
I
T
E
G
I
P
T
L
D
M
L
T
V
K
V
K
L
D
E
A
-
G
V
R
M
I
G
P
N
C
P
G
V
I
T
P
G
E
C
K
I
G
I
Q
P
G
H
I
H
K
P
G
K
V
G
I
V
S
R
S
G
T
L
T
Y
E
A
V
K
Q
T
T
D
Y
G
F
G
Q
S
T
C
V
G
I
G
G
D
P
I
P
G
S
N
F
I
D
I
L
E
M
F
E
K
D
P
Q
T
E
A
I
V
M
I
G
E
I
G
G
S
A
E
E
E
A
A
A
Y
I
K
-
E
H
V
---
T
K
P
V
V
G
Y
I
A
G
V
T
A
P
K
G
K
R
M
G
H
A
G
A
I
I
A
G
G
K
G
T
A
D
E
K
F
A
A
L
E
A
A
G
V
K
T
V
R
S
L
A
D
I
G
E
A
L
K
T
V
L
------
26
PsiBlast_CBE
93.00
62%
-116
- C4 -
2NUA
3
SUCD_ECOLI
D:
[1-287]
-
S
I
L
I
D
K
N
T
K
V
I
C
Q
G
F
T
G
S
Q
G
T
F
H
S
E
Q
A
I
A
Y
G
T
K
M
V
G
G
V
T
P
G
K
G
G
T
T
H
L
G
L
P
V
F
N
T
V
R
E
A
V
A
A
T
G
A
T
A
S
V
I
Y
V
P
A
P
F
C
K
D
S
I
L
E
A
I
D
A
G
I
K
L
I
I
T
I
T
E
G
I
P
T
L
D
M
L
T
V
K
V
K
L
D
E
A
-
G
V
R
M
I
G
P
N
V
P
G
V
I
T
P
G
E
C
K
I
G
I
Q
P
G
H
I
H
K
P
G
K
V
G
I
V
S
R
S
G
T
L
T
Y
E
A
V
K
Q
T
T
D
Y
G
F
G
Q
S
T
C
V
G
I
G
G
D
P
I
P
G
S
N
F
I
D
I
L
E
M
F
E
K
D
P
Q
T
E
A
I
V
M
I
G
E
I
G
G
S
A
E
E
E
A
A
A
Y
I
K
-
E
H
V
---
T
K
P
V
V
G
Y
I
A
G
V
T
A
P
K
G
K
R
M
G
H
A
G
A
I
I
A
G
G
K
G
T
A
D
E
K
F
A
A
L
E
A
A
G
V
K
T
V
R
S
L
A
D
I
G
E
A
L
K
T
V
L
------
24
PsiBlast_CBE
92.62
63%
-114
- C4 -
1CQJ
2
SUCD_ECOLI
D:
[1-286]
-
S
I
L
I
D
K
N
T
K
V
I
C
Q
G
F
T
G
S
Q
G
T
F
H
S
E
Q
A
I
A
Y
G
T
K
M
V
G
G
V
T
P
G
K
G
G
T
T
H
L
G
L
P
V
F
N
T
V
R
E
A
V
A
A
T
G
A
T
A
S
V
I
Y
V
P
A
P
F
C
K
D
S
I
L
E
A
I
D
A
G
I
K
L
I
I
T
I
T
E
G
I
P
T
L
D
M
L
T
V
K
V
K
L
D
E
A
-
G
V
R
M
I
G
P
N
C
P
G
V
I
T
P
G
E
C
K
I
G
I
Q
P
G
H
I
H
K
P
G
K
V
G
I
V
S
R
S
G
T
L
T
Y
E
A
V
K
Q
T
T
D
Y
G
F
G
Q
S
T
C
V
G
I
G
G
D
P
I
P
G
S
N
F
I
D
I
L
E
M
F
E
K
D
P
Q
T
E
A
I
V
M
I
G
E
I
G
G
S
A
E
E
E
A
A
A
Y
I
K
-
E
H
V
---
T
K
P
V
V
G
Y
I
A
G
V
T
A
P
K
G
K
R
M
G
H
A
G
A
I
I
A
G
G
K
G
T
A
D
E
K
F
A
A
L
E
A
A
G
V
K
T
V
R
S
L
A
D
I
G
E
A
L
K
T
V
-------
21
PsiBlast_CBE
92.37
62%
-114
- C4 -
1SCU
2
SUCD_ECOLI
D:
[1-287]
-
S
I
L
I
D
K
N
T
K
V
I
C
Q
G
F
T
G
S
Q
G
T
F
H
S
E
Q
A
I
A
Y
G
T
K
M
V
G
G
V
T
P
G
K
G
G
T
T
H
L
G
L
P
V
F
N
T
V
R
E
A
V
A
A
T
G
A
T
A
S
V
I
Y
V
P
A
P
F
C
K
D
S
I
L
E
A
I
D
A
G
I
K
L
I
I
T
I
T
E
G
I
P
T
L
D
M
L
T
V
K
V
K
L
D
E
A
-
G
V
R
M
I
G
P
N
C
P
G
V
I
T
P
G
E
C
K
I
G
I
Q
P
G
H
I
H
K
P
G
K
V
G
I
V
S
R
S
G
T
L
T
Y
E
A
V
K
Q
T
T
D
Y
G
F
G
Q
S
T
C
V
G
I
G
G
D
P
I
P
G
S
N
F
I
D
I
L
E
M
F
E
K
D
P
Q
T
E
A
I
V
M
I
G
E
I
G
G
S
A
E
E
E
A
A
A
Y
I
K
-
E
H
V
---
T
K
P
V
V
G
Y
I
A
G
V
T
A
P
K
G
K
R
M
G
H
A
G
A
I
I
A
G
G
K
G
T
A
D
E
K
F
A
A
L
E
A
A
G
V
K
T
V
R
S
L
A
D
I
G
E
A
L
K
T
V
L
K
-----
4
PsiBlast_PDB
92.30
63%
-114
- C4 -
1CQJ
2
SUCD_ECOLI
A:
[1-286]
-
S
I
L
I
D
K
N
T
K
V
I
C
Q
G
F
T
G
S
Q
G
T
F
H
S
E
Q
A
I
A
Y
G
T
K
M
V
G
G
V
T
P
G
K
G
G
T
T
H
L
G
L
P
V
F
N
T
V
R
E
A
V
A
A
T
G
A
T
A
S
V
I
Y
V
P
A
P
F
C
K
D
S
I
L
E
A
I
D
A
G
I
K
L
I
I
T
I
T
E
G
I
P
T
L
D
M
L
T
V
K
V
K
L
D
E
A
-
G
V
R
M
I
G
P
N
C
P
G
V
I
T
P
G
E
C
K
I
G
I
Q
P
G
H
I
H
K
P
G
K
V
G
I
V
S
R
S
G
T
L
T
Y
E
A
V
K
Q
T
T
D
Y
G
F
G
Q
S
T
C
V
G
I
G
G
D
P
I
P
G
S
N
F
I
D
I
L
E
M
F
E
K
D
P
Q
T
E
A
I
V
M
I
G
E
I
G
G
S
A
E
E
E
A
A
A
Y
I
K
-
E
H
V
---
T
K
P
V
V
G
Y
I
A
G
V
T
A
P
K
G
K
R
M
G
H
A
G
A
I
I
A
G
G
K
G
T
A
D
E
K
F
A
A
L
E
A
A
G
V
K
T
V
R
S
L
A
D
I
G
E
A
L
K
T
V
-------
3
PsiBlast_PDB
90.73
63%
-113
- C4 -
1CQI
2
SUCD_ECOLI
A:
[1-286]
-
S
I
L
I
D
K
N
T
K
V
I
C
Q
G
F
T
G
S
Q
G
T
F
H
S
E
Q
A
I
A
Y
G
T
K
M
V
G
G
V
T
P
G
K
G
G
T
T
H
L
G
L
P
V
F
N
T
V
R
E
A
V
A
A
T
G
A
T
A
S
V
I
Y
V
P
A
P
F
C
K
D
S
I
L
E
A
I
D
A
G
I
K
L
I
I
T
I
T
E
G
I
P
T
L
D
M
L
T
V
K
V
K
L
D
E
A
-
G
V
R
M
I
G
P
N
C
P
G
V
I
T
P
G
E
C
K
I
G
I
Q
P
G
H
I
H
K
P
G
K
V
G
I
V
S
R
S
G
T
L
T
Y
E
A
V
K
Q
T
T
D
Y
G
F
G
Q
S
T
C
V
G
I
G
G
D
P
I
P
G
S
N
F
I
D
I
L
E
M
F
E
K
D
P
Q
T
E
A
I
V
M
I
G
E
I
G
G
S
A
E
E
E
A
A
A
Y
I
K
-
E
H
V
---
T
K
P
V
V
G
Y
I
A
G
V
T
A
P
K
G
K
R
M
G
H
A
G
A
I
I
A
G
G
K
G
T
A
D
E
K
F
A
A
L
E
A
A
G
V
K
T
V
R
S
L
A
D
I
G
E
A
L
K
T
V
-------
25
PsiBlast_CBE
90.45
63%
-112
- C4 -
1CQI
2
SUCD_ECOLI
D:
[1-286]
-
S
I
L
I
D
K
N
T
K
V
I
C
Q
G
F
T
G
S
Q
G
T
F
H
S
E
Q
A
I
A
Y
G
T
K
M
V
G
G
V
T
P
G
K
G
G
T
T
H
L
G
L
P
V
F
N
T
V
R
E
A
V
A
A
T
G
A
T
A
S
V
I
Y
V
P
A
P
F
C
K
D
S
I
L
E
A
I
D
A
G
I
K
L
I
I
T
I
T
E
G
I
P
T
L
D
M
L
T
V
K
V
K
L
D
E
A
-
G
V
R
M
I
G
P
N
C
P
G
V
I
T
P
G
E
C
K
I
G
I
Q
P
G
H
I
H
K
P
G
K
V
G
I
V
S
R
S
G
T
L
T
Y
E
A
V
K
Q
T
T
D
Y
G
F
G
Q
S
T
C
V
G
I
G
G
D
P
I
P
G
S
N
F
I
D
I
L
E
M
F
E
K
D
P
Q
T
E
A
I
V
M
I
G
E
I
G
G
S
A
E
E
E
A
A
A
Y
I
K
-
E
H
V
---
T
K
P
V
V
G
Y
I
A
G
V
T
A
P
K
G
K
R
M
G
H
A
G
A
I
I
A
G
G
K
G
T
A
D
E
K
F
A
A
L
E
A
A
G
V
K
T
V
R
S
L
A
D
I
G
E
A
L
K
T
V
-------
13
PsiBlast_PDB
89.87
53%
-122
- C4 -
1OI7
-
SUCD_THETH
A:
[2-286]
--
I
L
V
N
R
E
T
R
V
L
V
Q
G
I
T
G
R
E
G
Q
F
H
T
K
Q
M
L
T
Y
G
T
K
I
V
A
G
V
T
P
G
K
G
G
M
E
V
L
G
V
P
V
Y
D
T
V
K
E
A
V
A
H
H
E
V
D
A
S
I
I
F
V
P
A
P
A
A
A
D
A
A
L
E
A
A
H
A
G
I
P
L
I
V
L
I
T
E
G
I
P
T
L
D
M
V
R
A
V
E
E
I
K
A
L
-
G
S
R
L
I
G
G
N
C
P
G
I
I
S
A
E
E
T
K
I
G
I
M
P
G
H
V
F
K
R
G
R
V
G
I
I
S
R
S
G
T
L
T
Y
E
A
A
A
A
L
S
Q
A
G
L
G
T
T
T
T
V
G
I
G
G
D
P
V
I
G
T
T
F
K
D
L
L
P
L
F
N
E
D
P
E
T
E
A
V
V
L
I
G
E
I
G
G
S
D
E
E
E
A
A
A
W
V
K
-
D
H
M
---
K
K
P
V
V
G
F
I
G
G
R
------------------
V
G
T
P
E
S
K
L
R
A
F
A
E
A
G
I
P
V
A
D
T
I
----
D
E
I
V
E
L
V
K
K
A
L
G
-
12
PsiBlast_PDB
88.84
54%
-114
- C4 -
3UFX
-
SUCD_THETH
A:
[2-286]
--
I
L
V
N
K
E
T
R
V
L
V
Q
G
I
T
G
R
E
G
Q
F
H
T
K
Q
M
L
S
Y
G
T
K
I
V
A
G
V
T
P
G
K
G
G
M
E
V
L
G
V
P
V
Y
D
T
V
K
E
A
V
A
H
H
E
V
D
A
S
I
I
F
V
P
A
P
A
A
A
D
A
A
L
E
A
A
H
A
G
I
P
L
I
V
L
I
T
E
G
I
P
T
L
D
M
V
R
A
V
E
E
I
K
A
L
-
G
S
R
L
I
G
G
N
C
P
G
I
I
S
A
E
E
T
K
I
G
I
M
P
G
H
V
F
K
R
G
R
V
G
I
I
S
R
S
G
T
L
T
Y
E
A
A
A
A
L
S
Q
A
G
L
G
T
T
T
T
V
G
I
G
G
D
P
V
I
G
T
T
F
K
D
L
L
P
L
F
N
E
D
P
E
T
E
A
V
V
L
I
G
E
I
G
G
S
D
E
E
E
A
A
A
W
V
K
-
D
H
M
---
K
K
P
V
V
G
F
I
G
G
R
S
A
P
K
G
K
R
M
G
H
A
G
A
I
I
M
G
N
V
G
T
P
E
S
K
L
R
A
F
A
E
A
G
I
P
V
A
D
T
I
----
D
E
I
V
E
L
V
K
K
A
L
G
-
30
Fugue
58.67
68%
-125
- C4 -
2SCU
1
SUCD_ECOLI
A:
[1-119]
-
S
I
L
I
D
K
N
T
K
V
I
C
Q
G
F
T
G
S
Q
G
T
F
H
S
E
Q
A
I
A
Y
G
T
K
M
V
G
G
V
T
P
G
K
G
G
T
T
H
L
G
L
P
V
F
N
T
V
R
E
A
V
A
A
T
G
A
T
A
S
V
I
Y
V
P
A
P
F
C
K
D
S
I
L
E
A
I
D
A
G
I
K
L
I
I
T
I
T
E
G
I
P
T
L
D
M
L
T
V
K
V
K
L
D
E
A
-
G
V
R
M
I
G
P
N
C
P
G
V
I
T
P
G
E
C
K
I
G
I
Q
P
G
H
I
H
K
P
G
K
V
G
I
V
S
R
S
G
T
L
T
Y
E
A
V
K
Q
T
T
D
Y
G
F
G
Q
S
T
C
V
G
I
G
G
D
P
I
P
G
S
N
F
I
D
I
L
E
M
F
E
K
D
P
Q
T
E
A
I
V
M
I
G
E
I
G
G
S
A
E
E
E
A
A
A
Y
I
K
E
H
V
T
---
K
P
V
V
G
Y
I
A
G
V
T
A
P
K
G
K
R
M
G
N
E
P
A
G
A
I
I
A
G
G
K
G
T
A
D
E
K
F
A
A
L
E
A
A
G
V
K
T
V
R
S
L
A
D
I
G
E
A
L
K
T
V
------