@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0540: (2015-12-02 )
MNNSLNSKTTLNVSGKSYGYFSLNAASKFLGIDLAKLPCSLKVLLENLLRNEDEVNVRLDDIKTLAGCVKKHVNHEISYKPARVLMQDFTGVPAIVDLASMRSYVKKKGGNPSKINPSVPVDLVIDHSVQVDSYGNTSAFGKNVELEIKRNLERYQFLKWGESSFTNFRVVPPGTGICHQVNLEYLAQVVCNESGVVYPDTLVGTDSHTTMVNGLSVLGWGVGGIEAESVMIGQPISMVIPEIVGFKLMGRLPEGVTATDLVLTITNILRAKGVVGKFVEFYGDGLDYLSLADRATIANMAPEYGATCGFFPIDQKTLDYLSLTGRPEGLIKLVEVYAKEQGLWRSGEELAFFDILELDLSGVEPVMAGPKRPQDKVSLSQVAESFSTSFSVNESKENDKLQDGSVVIAAITSCTNTSNPSVMIAAGLIARKAIKFGIKSKPWVKTSLAPGSRVVTKYLEKSGLQKNLNTLGFNLVGYGCTTCIGNSGPLNKDIEDDIKNKNLTVAAVLSGNRNFEGRIHPLVKANYLASPPLVVVYALAGTVQVDLTKDSICKDKNGNNVYLKDIWPTNNEIEDCVRSVVTCEMFMQKYKDVFSGDEHWQKIKYERGEIYNWDTKSTYIQNPPYFDDLLAGNDKDNVIDIKNARVLAMFGDSVTTDHISPAGNIASNSPAGIYLKNLGIEPQDFNSYGSRRGNHNVMMRGTFANIRIKNEMISNEGGYTKHIPSQETMSIFDTAMRYKEEAVPLVVIAGKEYGAGSSRDWAAKGTLLLGIKAVIAESFERIHRSNLVGMGVLPLIFQGGVTRRIFDSSEIISIKGEIVPSGNLECIIKRKDNSEQSIQLKCCVQTATEVKYLMSGGVLSYILAQSS
Atome Classification :
(20 SA)
......-...10........20........-30........40........50.....-...60...-..-----..-.70.....-...-------.80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.-.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340...----.----...350.......360.......370.......380......---------.390------------------.........400---------.........410.......420.......430.......440.......450.......460.......470.......480.....-..-490.......500.......510......--.520-.......530.......540.......550.......560.......570.......580.......590.......600-....-...610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800....--...810....--.-----..820..--.....830.......840.......850.......860.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNNSLN-SK
T
T
L
N
VSGK
S
Y
G
Y
F
S
LN
A
A
S
K
F
-LGI
D
L
A
KLP
C
S
L
K
V
L
L
E
N
L
LRNED
E
V
N
-
V
R
L
D
D
I
K
T
-
L
A
-----
G
C
-
V
K
-
K
HVNH-EIS-------Y
K
P
A
R
V
L
M
Q
DFTG
V
P
A
I
V
D
L
A
S
M
R
S
Y
V
K
KKGGNPSKINPSV
P
V
D
L
V
I
DH
S
V
Q
VDSYGNTSAFGK
N
V
E
L
E
IKRN
L
E
R
Y
Q
F
LKWGESSF
T
N
F
R
V
VPPGTGI
C
H
QV
N
L
E
Y
L
A
Q
V
V
CNESGVVYPD-TL-VGTDSH
T
T
M
V
NG
L
S
V
L
GWGVGGIEAE
S
V
MIGQ
P
I
S
M
V
I
P
E
I
V
G
F
K
L
M
GRLPEGV
T
A
T
D
L
V
L
T
I
T
N
I
L
R
AK
G
V
V
G
K
F
V
E
F
YGDGL
D
Y
L
S
LAD
R
A
T
I
A
NMAPEYGATCGFFPID
Q
K
T
L
D
Y
LSLTGR
P
E
G
L
I
K
L
V
E
V
Y
A
K
EQGLWR----S----GEE
L
A
F
F
D
I
L
E
L
DLSGVEPVMAGPKRP
Q
D
KV
S
L
S
Q
V
A
E
S
FST---------
S
F
--------------------SVNESKENDK-----------LQDG
S
V
V
I
A
A
I
TSCTNTSNP
S
V
M
I
A
A
G
L
I
A
R
K
A
I
KFGIKSK
P
W
V
KTSLAP
G
S
R
V
V
T
K
Y
L
E
K
S
G
L
Q
K
N
L
N
T
LGFNLVGYGCTTCIGNS-GP-LNK
D
I
E
D
DIKNKN
L
T
V
A
A
V
LSGNRNFE
G
R
--
I
H
P
L
-
V
KANYLASP
P
L
V
V
V
Y
A
LA
G
T
V
Q
V
D
LTK
D
S
ICKDKNG
N
N
V
Y
L
K
DIWPTN
N
E
I
E
D
C
V
R
S
V
V
T
C
E
M
F
M
Q
K
Y
K
D
VFSG
D
E
H
W
Q
K
-
I
KYE-RG
E
I
YNWDTKS
T
Y
IQNPP
Y
F
D
D
L
LAGNDKD
N
V
I
D
IKN
A
R
V
L
A
M
FGDSVTTDHISPAGNIASNSP
A
G
I
Y
L
KNLGIEPQ
D
F
N
S
Y
GSRRGNH
N
V
M
M
R
G
T
F
A
N
I
R
I
K
N
E
MISNEGGYTKHIP
S
Q
E
T
M
S
I
F
D
T
A
M
R
Y
KEEAV
P
L
V
V
I
AGKEYGAGSSRDWAAKG
T
L
L
L
G
I
K
A
V
I
A
E
S
F
E
R
I
H
R
SNLVGM
G
V
L
P
L
I
FQGGV
T
R
R
IF--DSS
E
I
I
S
I
K
G
--
E
-----
I
VPSGN
L
--
E
C
I
I
K
RKDNSE
Q
S
I
Q
L
K
C
C
VQ
T
A
T
E
V
K
Y
L
MSG
G
V
L
S
Y
I
LAQSS
2
PsiBlast_PDB
97.80
51%
-81
- C3 -
2B3Y
4
ACOC_HUMAN
A:
[20-883]
--------------------
F
F
N
L
N
---
K
L
-
E
D
S
R
Y
G
R
L
P
F
S
I
R
V
L
L
E
A
A
I
R
N
C
D
E
F
L
-
V
K
K
Q
D
I
E
N
I
L
H
-----
W
N
-
V
T
-
Q
H
K
N
I
-
E
V
P
-------
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
A
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
V
C
P
A
D
L
V
I
D
H
S
I
Q
V
D
F
N
R
R
A
D
S
L
Q
K
N
Q
D
L
E
F
E
R
N
R
E
R
F
E
F
L
K
W
G
S
Q
A
F
H
N
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
F
D
Q
D
G
Y
Y
Y
P
D
-
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
I
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
A
F
F
P
V
D
E
V
S
I
T
Y
L
V
Q
T
G
R
D
E
E
K
L
K
Y
I
K
K
Y
L
Q
A
V
G
M
F
R
----
D
FNDP
S
Q
D
P
D
F
T
Q
V
V
E
L
D
L
K
T
V
V
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
S
C
L
G
AKQGFK
G
F
--------------------
Q
V
A
P
E
H
H
N
D
H
K
T
F
I
Y
DN
T
E
F
T
L
A
H
G
S
V
V
I
A
A
I
T
S
C
T
N
T
S
N
P
S
V
M
L
G
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
M
P
Y
I
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
Q
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
G
Y
G
C
M
T
C
I
G
N
S
-
G
P
-
L
P
E
P
V
V
E
A
I
T
Q
G
D
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
--
V
H
P
N
-
T
R
A
N
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
E
P
L
G
V
N
A
K
G
Q
Q
V
F
L
K
D
I
W
P
T
R
D
E
I
Q
A
V
E
R
Q
Y
V
I
P
G
M
F
K
E
V
Y
Q
K
I
E
T
V
N
E
S
W
N
A
-
L
A
T
P
-
S
D
K
L
F
F
W
N
S
K
S
T
Y
I
K
S
P
P
F
F
E
N
L
T
L
--
D
L
Q
P
P
K
S
I
V
D
A
Y
V
L
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
D
A
V
M
A
R
G
T
F
A
N
I
R
L
L
N
R
F
L
N
K
Q
A
P
Q
T
I
H
L
P
S
G
E
I
L
D
V
F
D
A
A
E
R
Y
Q
Q
A
G
L
P
L
I
V
L
A
G
K
E
Y
G
A
G
S
S
R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
L
P
G
--------
E
N
A
D
A
L
G
L
T
G
--
Q
E
R
Y
T
I
I
I
P
E
-
N
L
K
P
Q
M
K
V
Q
V
K
L
D
T
G
K
T
F
Q
A
V
M
R
F
D
T
D
V
E
L
T
Y
F
L
N
G
G
I
L
N
Y
M
I
R
K
M
A
1
PsiBlast_PDB
97.70
51%
-84
- C3 -
2B3X
3
ACOC_HUMAN
A:
[20-883]
--------------------
F
F
N
L
N
---
K
L
-
E
D
S
R
Y
G
R
L
P
F
S
I
R
V
L
L
E
A
A
I
R
N
C
D
E
F
L
-
V
K
K
Q
D
I
E
N
I
L
H
-----
W
N
-
V
T
-
Q
H
K
N
I
-
E
V
P
-------
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
A
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
V
C
P
A
D
L
V
I
D
H
S
I
Q
V
D
F
N
R
R
A
D
S
L
Q
K
N
Q
D
L
E
F
E
R
N
R
E
R
F
E
F
L
K
W
G
S
Q
A
F
H
N
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
F
D
Q
D
G
Y
Y
Y
P
D
-
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
I
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
A
F
F
P
V
D
E
V
S
I
T
Y
L
V
Q
T
G
R
D
E
E
K
L
K
Y
I
K
K
Y
L
Q
A
V
G
M
F
R
----
D
FNDP
S
Q
D
P
D
F
T
Q
V
V
E
L
D
L
K
T
V
V
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
S
C
L
G
AKQGFK
G
F
--------------------
Q
V
A
P
E
H
H
N
D
H
K
T
F
I
Y
DN
T
E
F
T
L
A
H
G
S
V
V
I
A
A
I
T
S
C
T
N
T
S
N
P
S
V
M
L
G
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
M
P
Y
I
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
Q
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
G
Y
G
C
M
T
C
I
G
N
S
-
G
P
-
L
P
E
P
V
V
E
A
I
T
Q
G
D
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
--
V
H
P
N
-
T
R
A
N
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
E
P
L
G
V
N
A
K
G
Q
Q
V
F
L
K
D
I
W
P
T
R
D
E
I
Q
A
V
E
R
Q
Y
V
I
P
G
M
F
K
E
V
Y
Q
K
I
E
T
V
N
E
S
W
N
A
-
L
A
T
P
-
S
D
K
L
F
F
W
N
S
K
S
T
Y
I
K
S
P
P
F
F
E
N
L
T
L
--
D
L
Q
P
P
K
S
I
V
D
A
Y
V
L
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
D
A
V
M
A
R
G
T
F
A
N
I
R
L
L
N
R
F
L
N
K
Q
A
P
Q
T
I
H
L
P
S
G
E
I
L
D
V
F
D
A
A
E
R
Y
Q
Q
A
G
L
P
L
I
V
L
A
G
K
E
Y
G
A
G
S
S
R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
L
P
G
--------
E
N
A
D
A
L
G
L
T
G
--
Q
E
R
Y
T
I
I
I
P
E
-
N
L
KP
Q
M
K
V
Q
V
K
L
D
T
G
K
T
F
Q
A
V
M
R
F
D
T
D
V
E
L
T
Y
F
L
N
G
G
I
L
N
Y
M
I
R
K
M
A
21
PsiBlast_CBE
97.66
51%
-82
- C3 -
2B3Y
4
ACOC_HUMAN
B:
[20-883]
--------------------
F
F
N
L
N
---
K
L
-
E
D
S
R
Y
G
R
L
P
F
S
I
R
V
L
L
E
A
A
I
R
N
C
D
E
F
L
-
V
K
K
Q
D
I
E
N
I
L
H
-----
W
N
-
V
T
-
Q
H
K
N
I
-
E
V
P
-------
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
A
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
V
C
P
A
D
L
V
I
D
H
S
I
Q
V
D
F
N
R
R
A
D
S
L
Q
K
N
Q
D
L
E
F
E
R
N
R
E
R
F
E
F
L
K
W
G
S
Q
A
F
H
N
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
F
D
Q
D
G
Y
Y
Y
P
D
-
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
I
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
A
F
F
P
V
D
E
V
S
I
T
Y
L
V
Q
T
G
R
D
E
E
K
L
K
Y
I
K
K
Y
L
Q
A
V
G
M
F
R
----
D
FNDP
S
Q
D
P
D
F
T
Q
V
V
E
L
D
L
K
T
V
V
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
S
CLGAKQGFK
G
F
--------------------
Q
V
A
P
E
H
H
N
D
H
KTFIYDNTEFT
L
A
H
G
S
V
V
I
A
A
I
T
S
C
T
N
T
S
N
P
S
V
M
L
G
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
M
P
Y
I
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
Q
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
G
Y
G
C
M
T
C
I
G
N
S
-
G
P
-
L
P
E
P
V
V
E
A
I
T
Q
G
D
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
--
V
H
P
N
-
T
R
A
N
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
E
P
L
G
V
N
A
K
G
Q
Q
V
F
L
K
D
I
W
P
T
R
D
E
I
Q
A
V
E
R
Q
Y
V
I
P
G
M
F
K
E
V
Y
Q
K
I
E
T
V
N
E
S
W
N
A
-
L
A
T
P
-
S
D
K
L
F
F
W
N
S
K
S
T
Y
I
K
S
P
P
F
F
E
N
L
T
L
--
D
L
Q
P
P
K
S
I
V
D
A
Y
V
L
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
D
A
V
M
A
R
G
T
F
A
N
I
R
L
L
N
R
F
L
N
K
Q
A
P
Q
T
I
H
L
P
S
G
E
I
L
D
V
F
D
A
A
E
R
Y
Q
Q
A
G
L
P
L
I
V
L
A
G
K
E
Y
G
A
G
S
S
R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
L
P
G
--------
E
N
A
D
A
L
G
L
T
G
--
Q
ERYTI
I
I
P
E
-
N
L
KP
Q
M
K
V
Q
V
K
L
D
T
G
K
T
F
Q
A
V
M
R
F
D
T
D
V
E
L
T
Y
F
L
N
G
G
I
L
N
Y
M
I
R
K
M
A
26
HHSearch
97.49
52%
-82
* C3 *
2B3Y
4
ACOC_HUMAN
A:
[1-887]
-
S
N
P
F
A
H
L
A
E
P
L
D
P
V
Q
P
G
K
K
F
F
N
L
N
K
L
E
D
----
S
R
Y
G
R
L
P
F
S
I
R
V
L
L
E
A
A
I
R
N
C
D
E
F
L
V
K
K
-
Q
D
I
E
N
-
I
L
-----
H
W
-
N
V
T
Q
H
K
N
I
-
E
V
P
-------
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
A
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
V
C
P
A
D
L
V
I
D
H
S
I
Q
V
D
F
N
R
R
A
D
S
L
Q
K
N
Q
D
L
E
F
E
R
N
R
E
R
F
E
F
L
K
W
G
S
Q
A
F
H
N
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
F
D
Q
D
G
Y
Y
Y
P
D
-
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
I
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
A
F
F
P
V
D
E
V
S
I
T
Y
L
V
Q
T
G
R
D
E
E
K
L
K
Y
I
K
K
Y
L
Q
A
V
G
M
F
R
DFND
P
----
S
Q
D
P
D
F
T
Q
V
V
E
L
D
L
K
T
V
V
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
S
---------
C
L
G
AKQGFKGFQVAPEHHN
D
H
K
T
F
I
Y
D
N
T
E
F
T
-----------
L
A
H
G
S
V
V
I
A
A
I
T
S
C
T
N
T
S
N
P
S
V
M
L
G
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
M
P
Y
I
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
Q
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
G
Y
G
C
M
T
C
I
G
N
S
-
G
P
-
L
P
E
P
V
V
E
A
I
T
Q
G
D
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
--
V
H
P
N
-
T
R
A
N
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
E
P
L
G
V
N
A
K
G
Q
Q
V
F
L
K
D
I
W
P
T
R
D
E
I
Q
A
V
E
R
Q
Y
V
I
P
G
M
F
K
E
V
Y
Q
K
I
E
T
V
N
E
S
W
N
A
-
L
A
T
P
-
S
D
K
L
F
F
W
N
S
K
S
T
Y
I
K
S
P
P
F
F
E
N
L
T
L
--
D
L
Q
P
P
K
S
I
V
D
A
Y
V
L
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
D
A
V
M
A
R
G
T
F
A
N
I
R
L
L
N
R
F
L
N
K
Q
A
P
Q
T
I
H
L
P
S
G
E
I
L
D
V
F
D
A
A
E
R
Y
Q
Q
A
G
L
P
L
I
V
L
A
G
K
E
Y
G
A
G
S
S
R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
L
P
G
E
N
A
D
A
L
GL
T
G
Q
E
R
Y
T
I
I
I
P
E
N
-----
L
K
P
Q
M
K
V
--
Q
V
K
L
D
--
T
G
--
K
T
F
Q
A
V
M
R
F
D
T
D
V
E
L
T
Y
F
L
N
G
G
I
L
N
Y
M
I
R
K
M
A
3
PsiBlast_PDB
94.20
51%
-91
- C3 -
3SNP
-
ACOC_RABIT
A:
[34-884]
-------------------------------------
R
L
P
F
S
I
R
V
L
L
E
A
A
V
R
N
C
D
K
F
L
-
V
K
K
E
D
I
E
N
-
I
L
-----
N
W
N
V
T
-
Q
H
M
N
I
-
E
V
P
-------
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
S
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
I
C
P
V
D
L
V
I
D
H
S
------------------
E
F
E
R
N
R
E
R
F
E
F
L
K
W
G
S
K
A
F
R
N
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
F
D
Q
D
G
Y
Y
Y
P
D
-
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
V
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
T
F
F
P
V
D
E
V
S
I
K
Y
L
V
Q
T
G
R
D
E
S
K
V
K
Q
I
R
K
Y
L
Q
A
V
G
M
F
R
----
D
YSDP
S
Q
D
P
D
F
T
Q
V
V
E
L
D
L
K
T
V
V
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
S
C
L
G
AKQGFK
G
F
--------------------
Q
V
A
P
D
H
H
N
D
H
K
T
F
I
Y
ND
S
E
F
T
L
S
H
G
S
V
V
I
A
A
I
T
S
S
T
N
T
S
N
P
S
V
M
L
G
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
K
P
Y
V
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
R
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
-------------
P
-
L
P
E
P
V
V
E
A
I
T
Q
G
D
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
--
V
H
P
N
-
T
R
A
N
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
E
P
L
G
T
N
A
K
G
Q
Q
V
F
L
R
D
I
W
P
T
R
E
E
I
Q
A
V
E
R
Q
Y
V
I
P
G
M
F
T
E
V
Y
Q
K
I
E
T
V
N
A
S
W
----------
K
L
Y
L
W
N
P
K
S
T
Y
I
K
S
P
P
F
F
E
N
L
T
L
--
D
L
Q
P
P
K
S
I
V
D
A
Y
V
L
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
D
A
I
M
A
R
G
T
F
A
N
I
R
L
L
N
R
F
L
N
K
Q
A
P
Q
T
I
H
L
P
S
G
E
T
L
D
V
F
D
A
A
E
R
Y
Q
Q
E
G
H
P
L
I
V
L
A
G
K
E
Y
G
S
G
S
S
R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
L
P
G
--------
E
N
A
D
S
L
G
L
T
G
--
R
E
R
Y
T
I
I
I
P
E
-
N
L
TP
R
M
H
V
Q
V
K
L
D
T
G
K
T
F
Q
A
V
I
R
F
D
T
D
V
E
L
T
Y
F
H
N
G
G
I
L
N
Y
M
I
R
K
M
A
4
PsiBlast_PDB
94.12
51%
-93
- C3 -
3SN2
-
ACOC_RABIT
A:
[34-884]
-------------------------------------
R
L
P
F
S
I
R
V
L
L
E
A
A
V
R
N
C
D
K
F
L
-
V
K
K
E
D
I
E
N
-
I
L
-----
N
W
N
V
T
-
Q
H
M
N
I
-
E
V
P
-------
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
S
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
I
C
P
V
D
L
V
I
D
---------------------
F
E
R
N
R
E
R
F
E
F
L
K
W
G
S
K
A
F
R
N
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
F
D
Q
D
G
Y
Y
Y
P
D
-
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
V
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
T
F
F
P
V
D
E
V
S
I
K
Y
L
V
Q
T
G
R
D
E
S
K
V
K
Q
I
R
K
Y
L
Q
A
V
G
M
F
R
----
D
YSDP
S
Q
D
P
D
F
T
Q
V
V
E
L
D
L
K
T
V
V
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
S
C
L
G
A
KQGFK
G
F
--------------------
Q
V
A
P
D
H
H
N
D
H
K
T
F
I
Y
ND
S
E
F
T
L
S
H
G
S
V
V
I
A
A
I
T
S
S
T
N
T
S
N
P
S
V
M
L
G
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
K
P
Y
V
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
R
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
-------------
P
-
L
P
E
P
V
V
E
A
I
T
Q
G
D
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
--
V
H
P
N
-
T
R
A
N
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
E
P
L
G
T
N
A
K
G
Q
Q
V
F
L
R
D
I
W
P
T
R
E
E
I
Q
A
V
E
R
Q
Y
V
I
P
G
M
F
T
E
V
Y
Q
K
I
E
T
V
N
A
S
---------
S
D
K
L
Y
L
W
N
P
K
S
T
Y
I
K
S
P
P
F
F
E
N
L
T
L
--
D
L
Q
P
P
K
S
I
V
D
A
Y
V
L
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
D
A
I
M
A
R
G
T
F
A
N
I
R
L
L
N
R
F
L
N
K
Q
A
P
Q
T
I
H
L
P
S
G
E
T
L
D
V
F
D
A
A
E
R
Y
Q
Q
E
G
H
P
L
I
V
L
A
G
K
E
Y
G
S
G
S
S
R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
L
P
G
--------
E
N
A
D
S
L
G
L
T
G
--
R
E
R
Y
T
I
I
I
P
E
-
N
L
TP
R
M
H
V
Q
V
K
L
D
T
G
K
T
F
Q
A
V
I
R
F
D
T
D
V
E
L
T
Y
F
H
N
G
G
I
L
N
Y
M
I
R
K
M
A
27
HHSearch
74.95
29%
-67
- C3 -
1C96
3
ACON_BOVIN
A:
[13-752]
----------------
E
Y
I
R
Y
D
L
L
E
K
N
I
D
I
V
R
K
R
L
N
R
P
L
T
L
S
E
K
I
V
Y
G
H
L
D
D
P
A
N
-------
Q
E
I
-----------------
E
R
G
K
T
Y
L
R
-------
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
-------
G
-
L
P
K
V
A
V
P
S
---
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
-----
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
-
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
----------
Y
A
Y
P
G
V
L
L
-
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
A
D
I
-
A
N
L
A
D
E
F
K
D
---
H
L
V
----
P
----
D
P
G
C
H
Y
D
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
K
----------------------------------------
E
-----------
G
W
P
L
D
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
-
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
--
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
R
K
D
I
K
K
G
---------
E
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
--
N
D
A
N
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
T
G
-
K
D
G
K
K
F
K
--
L
E
A
P
D
A
D
E
L
P
R
A
E
F
---------------
D
P
G
Q
D
T
Y
Q
H
-
P
P
K
D
S
S
G
Q
R
V
A
V
S
P
T
S
Q
R
L
Q
L
L
E
P
F
D
K
W
-------
D
G
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
W
---------
L
K
F
R
G
H
L
D
N
I
S
N
N
L
-------------
L
I
G
A
I
N
I
E
N
R
K
A
----
N
S
V
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
A
S
R
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
--
H
P
V
D
K
L
T
I
Q
G
LK
D
-----
F
A
P
G
K
P
L
--
K
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
-
N
H
T
F
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
L
Q
Q
5
PsiBlast_PDB
74.85
28%
-69
- C3 -
1AMI
2
ACON_BOVIN
A:
[21-748]
-------------------------------------------------
L
E
K
N
I
D
I
V
R
-
K
R
L
N
R
P
L
T
-
L
S
E
K
I
V
Y
G
H
-
L
D
-
D
P
A
N
Q
-
E
I
E
R
GKTYLR
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
--------
S
G
L
P
K
V
---
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
-----
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
-
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
----------
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
A
D
-
I
A
N
L
A
D
E
F
-
K
D
H
L
V
P
D
----
S
----
G
--
C
H
Y
D
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
------------------------------------
S
V
A
E
-
K
E
G
W
P
-----------
L
---
D
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
-
V
A
K
Q
A
L
A
H
G
L
K
C
K
--
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
-
D
---
R
K
D
I
K
K
G
E
K
N
-----
T
I
V
T
S
Y
N
R
N
F
T
G
R
ND
A
N
P
E
-
T
H
A
-
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
T
-
G
K
D
G
K
K
F
K
L
E
A
--
P
D
A
D
E
L
P
R
A
---------------
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
-
S
G
Q
R
V
D
V
S
P
T
S
Q
R
L
Q
-------
L
L
E
P
F
D
K
W
D
G
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
---------
W
L
K
--------
F
R
G
H
L
D
N
I
S
N
-
N
L
L
I
G
A
I
N
S
E
N
R
K
A
N
S
V
--------
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
S
A
L
E
P
R
F
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
--
H
P
V
D
K
L
T
I
Q
G
LK
D
-----
F
A
P
G
K
P
L
--
T
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
-
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
L
Q
Q
7
PsiBlast_PDB
74.80
28%
-68
- C3 -
1ACO
2
ACON_BOVIN
A:
[21-748]
-------------------------------------------------
L
E
K
N
I
D
I
V
R
-
K
R
L
N
R
P
L
T
-
L
S
E
K
I
V
Y
G
H
-
L
D
-
D
P
A
N
Q
-
E
I
E
R
G
K
T
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
--------
S
G
L
P
K
V
---
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
-----
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
-
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
----------
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
A
D
-
I
A
N
L
A
D
E
F
-
K
D
H
L
V
P
D
----
S
----
G
--
C
H
Y
D
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
------------------------------------
S
V
A
E
-
K
E
G
W
P
-----------
L
---
D
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
-
V
A
K
Q
A
L
A
H
G
L
K
C
K
--
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
-
D
---
R
K
D
I
K
K
G
E
K
N
-----
T
I
V
T
S
Y
N
R
N
F
T
G
R
ND
A
N
P
E
-
T
H
A
-
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
T
-
G
K
D
G
K
K
F
K
L
E
A
--
P
D
A
D
E
L
P
R
A
---------------
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
-
S
G
Q
R
V
D
V
S
P
T
S
Q
R
L
Q
-------
L
L
E
P
F
D
K
W
D
G
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
---------
W
L
K
--------
F
R
G
H
L
D
N
I
S
N
-
N
L
L
I
G
A
I
N
S
E
N
R
K
A
N
S
V
--------
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
S
A
L
E
P
R
F
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
--
H
P
V
D
K
L
T
I
Q
G
LK
D
-----
F
A
P
G
K
P
L
--
T
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
-
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
L
Q
Q
9
PsiBlast_PDB
74.70
28%
-69
- C3 -
8ACN
2
ACON_BOVIN
A:
[21-748]
-------------------------------------------------
L
E
K
N
I
D
I
V
R
-
K
R
L
N
R
P
L
T
-
L
S
E
K
I
V
Y
G
H
-
L
D
-
D
P
A
N
Q
-
E
I
E
R
G
K
T
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
--------
S
G
L
P
K
V
---
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
-----
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
-
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
----------
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
A
D
-
I
A
N
L
A
D
E
F
-
K
D
H
L
V
P
D
----
S
----
G
--
C
H
Y
D
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
------------------------------------
S
V
A
E
-
K
E
G
W
P
-----------
L
---
D
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
-
V
A
K
Q
A
L
A
H
G
L
K
C
K
--
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
-
D
---
R
K
D
I
K
K
G
E
K
N
-----
T
I
V
T
S
Y
N
R
N
F
T
G
R
ND
A
N
P
E
-
T
H
A
-
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
T
-
G
K
D
G
K
K
F
K
L
E
A
--
P
D
A
D
E
L
P
R
A
---------------
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
-
S
G
Q
R
V
D
V
S
P
T
S
Q
R
L
Q
-------
L
L
E
P
F
D
K
W
D
G
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
---------
W
L
K
--------
F
R
G
H
L
D
N
I
S
N
-
N
L
L
I
G
A
I
N
S
E
N
R
K
A
N
S
V
--------
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
S
A
L
E
P
R
F
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
--
H
P
V
D
K
L
T
I
Q
G
LK
D
-----
F
A
P
G
K
P
L
--
T
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
-
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
L
Q
Q
8
PsiBlast_PDB
74.60
28%
-69
- C3 -
1FGH
2
ACON_BOVIN
A:
[21-748]
-------------------------------------------------
L
E
K
N
I
D
I
V
R
-
K
R
L
N
R
P
L
T
-
L
S
E
K
I
V
Y
G
H
-
L
D
-
D
P
A
N
Q
-
E
I
E
R
G
K
T
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
--------
S
G
L
P
K
V
---
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
-----
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
-
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
----------
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
A
D
-
I
A
N
L
A
D
E
F
-
K
D
H
L
V
P
D
----
S
----
G
--
C
H
Y
D
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
------------------------------------
S
V
A
E
-
K
E
G
W
P
-----------
L
---
D
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
-
V
A
K
Q
A
L
A
H
G
L
K
C
K
--
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
-
D
---
R
K
D
I
K
K
G
E
K
N
-----
T
I
V
T
S
Y
N
R
N
F
T
G
R
ND
A
N
P
E
-
T
H
A
-
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
T
-
G
K
D
G
K
K
F
K
L
E
A
--
P
D
A
D
E
L
P
R
A
---------------
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
-
S
G
Q
R
V
D
V
S
P
T
S
Q
R
L
Q
-------
L
L
E
P
F
D
K
W
D
G
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
---------
W
L
K
--------
F
R
G
H
L
D
N
I
S
N
-
N
L
L
I
G
A
I
N
S
E
N
R
K
A
N
S
V
--------
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
S
A
L
E
P
R
F
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
--
H
P
V
D
K
L
T
I
Q
G
LK
D
-----
F
A
P
G
K
P
L
--
T
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
-
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
L
Q
Q
6
PsiBlast_PDB
74.49
28%
-68
- C3 -
1AMJ
3
ACON_BOVIN
A:
[21-748]
-------------------------------------------------
L
E
K
N
I
D
I
V
R
-
K
R
L
N
R
P
L
T
-
L
S
E
K
I
V
Y
G
H
-
L
D
-
D
P
A
N
Q
-
E
I
E
R
G
K
T
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
--------
S
G
L
P
K
V
---
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
-----
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
-
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
----------
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
A
D
-
I
A
N
L
A
D
E
F
-
K
D
H
L
V
P
D
----
S
----
G
--
C
H
Y
D
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
------------------------------------
S
V
A
E
-
K
E
G
W
P
-----------
L
---
D
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
-
V
A
K
Q
A
L
A
H
G
L
K
C
K
--
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
-
D
---
R
K
D
I
K
K
G
E
K
N
-----
T
I
V
T
S
Y
N
R
N
F
T
G
R
ND
A
N
P
E
-
T
H
A
-
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
T
-
G
K
D
G
K
K
F
K
L
E
A
--
P
D
A
D
E
L
P
R
A
---------------
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
-
S
G
Q
R
V
D
V
S
P
T
S
Q
R
L
Q
-------
L
L
E
P
F
D
K
W
D
G
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
---------
W
L
K
--------
F
R
G
H
L
D
N
I
S
N
-
N
L
L
I
G
A
I
N
S
E
N
R
K
A
N
S
V
--------
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
S
A
L
E
P
R
F
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
--
H
P
V
D
K
L
T
I
Q
G
LK
D
-----
F
A
P
G
K
P
L
--
T
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
-
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
L
Q
Q
11
PsiBlast_PDB
74.47
28%
-68
- C3 -
1NIT
2
ACON_BOVIN
A:
[21-748]
-------------------------------------------------
L
E
K
N
I
D
I
V
R
-
K
R
L
N
R
P
L
T
-
L
S
E
K
I
V
Y
G
H
-
L
D
-
D
P
A
N
Q
-
E
I
E
R
G
K
T
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
--------
S
G
L
P
K
V
---
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
-----
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
-
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
----------
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
A
D
-
I
A
N
L
A
D
E
F
-
K
D
H
L
V
P
D
----
S
----
G
--
C
H
Y
D
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
------------------------------------
S
V
A
E
-
K
E
G
W
P
-----------
L
---
D
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
-
V
A
K
Q
A
L
A
H
G
L
K
C
K
--
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
-
D
---
R
K
D
I
K
K
G
E
K
N
-----
T
I
V
T
S
Y
N
R
N
F
T
G
R
ND
A
N
P
E
-
T
H
A
-
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
T
-
G
K
D
G
K
K
F
K
L
E
A
--
P
D
A
D
E
L
P
R
A
---------------
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
-
S
G
Q
R
V
D
V
S
P
T
S
Q
R
L
Q
-------
L
L
E
P
F
D
K
W
D
G
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
---------
W
L
K
--------
F
R
G
H
L
D
N
I
S
N
-
N
L
L
I
G
A
I
N
S
E
N
R
K
A
N
S
V
--------
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
R
A
L
E
P
R
F
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
--
H
P
V
D
K
L
T
I
Q
G
LK
D
-----
F
A
P
G
K
P
L
--
T
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
-
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
L
Q
Q
15
PsiBlast_PDB
74.40
28%
-66
- C3 -
1C97
3
ACON_BOVIN
A:
[20-747]
-------------------------------------------------
L
E
K
N
I
D
I
V
R
-
K
R
L
N
R
P
L
T
-
L
S
E
K
I
V
Y
G
H
-
L
D
-
D
P
A
N
Q
-
E
I
E
RGKTYLR
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
--------
S
G
L
P
K
V
---
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
-----
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
-
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
----------
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
A
D
-
I
A
N
L
A
D
E
F
-
K
D
H
L
V
P
D
----
P
----
G
--
C
H
Y
D
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
------------------------------------
S
V
A
E
-
K
E
G
W
P
-----------
L
---
D
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
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S
A
A
-
V
A
K
Q
A
L
A
H
G
L
K
C
K
--
S
Q
F
T
I
T
P
G
S
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Q
I
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A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
-
D
---
R
K
D
I
K
K
G
E
K
N
-----
T
I
V
T
S
Y
N
R
N
F
T
G
R
ND
A
N
P
E
-
T
H
A
-
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
T
-
G
K
D
G
K
K
F
K
L
E
A
--
P
D
A
D
E
L
P
R
A
---------------
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
-
S
G
Q
R
V
D
V
S
P
T
S
Q
R
L
Q
-------
L
L
E
P
F
D
K
W
D
G
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
---------
W
L
K
--------
F
R
G
H
L
D
N
I
S
N
-
N
L
L
I
----
G
A
I
N
I
E
N
R
K
A
N
S
----
V
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
A
S
R
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
--
H
P
V
D
K
L
T
I
Q
G
LK
D
-----
F
A
P
G
K
P
L
--
K
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
-
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
L
Q
Q
14
PsiBlast_PDB
74.34
28%
-68
- C3 -
7ACN
2
ACON_PIG
A:
[21-748]
-------------------------------------------------
L
E
K
N
I
D
I
V
R
-
K
R
L
N
R
P
L
T
-
L
S
E
K
I
V
Y
G
H
-
L
D
-
D
P
A
N
Q
-
E
I
E
R
G
K
T
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
--------
S
G
L
P
K
V
---
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
-----
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
-
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
----------
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
A
D
-
I
A
N
L
A
D
E
F
-
K
D
H
L
V
P
D
----
P
----
G
--
C
H
Y
D
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
------------------------------------
S
V
A
E
-
K
E
G
W
P
-----------
L
---
D
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
-
V
A
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Q
A
L
A
H
G
L
K
C
K
--
S
Q
F
T
I
T
P
G
S
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Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
-
D
---
R
K
D
I
K
K
G
E
K
N
-----
T
I
V
T
S
Y
N
R
N
F
T
G
R
ND
A
N
P
E
-
T
H
A
-
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
T
-
G
K
D
G
K
K
F
K
L
E
A
--
P
D
A
D
E
L
P
R
A
---------------
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
-
S
G
Q
R
V
D
V
S
P
T
S
Q
R
L
Q
-------
L
L
E
P
F
D
K
W
D
G
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
---------
W
L
K
--------
F
R
G
H
L
D
N
I
S
N
-
N
L
L
I
----
G
A
I
N
I
E
N
R
K
A
N
S
----
V
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
--
H
P
V
D
K
L
T
I
Q
G
LK
D
-----
F
A
P
G
K
P
L
--
K
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
-
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
L
Q
Q
10
PsiBlast_PDB
74.11
28%
-68
- C3 -
1NIS
2
ACON_BOVIN
A:
[21-748]
-------------------------------------------------
L
E
K
N
I
D
I
V
R
-
K
R
L
N
R
P
L
T
-
L
S
E
K
I
V
Y
G
H
-
L
D
-
D
P
A
N
Q
-
E
I
E
R
G
K
T
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
--------
S
G
L
P
K
V
---
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
-----
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
-
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
----------
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
A
D
-
I
A
N
L
A
D
E
F
-
K
D
H
L
V
P
D
----
S
----
G
--
C
H
Y
D
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
------------------------------------
S
V
A
E
-
K
E
G
W
P
-----------
L
---
D
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
-
V
A
K
Q
A
L
A
H
G
L
K
C
K
--
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
-
D
---
R
K
D
I
K
K
G
E
K
N
-----
T
I
V
T
S
Y
N
R
N
F
T
G
R
ND
A
N
P
E
-
T
H
A
-
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
T
-
G
K
D
G
K
K
F
K
L
E
A
--
P
D
A
D
E
L
P
R
A
---------------
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
-
S
G
Q
R
V
D
V
S
P
T
S
Q
R
L
Q
-------
L
L
E
P
F
D
K
W
D
G
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
---------
W
L
K
--------
F
R
G
H
L
D
N
I
S
N
-
N
L
L
I
G
A
I
N
S
E
N
R
K
A
N
S
V
--------
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
R
A
L
E
P
R
F
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
--
H
P
V
D
K
L
T
I
Q
G
LK
D
-----
F
A
P
G
K
P
L
--
T
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
-
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
L
Q
Q
19
PsiBlast_PDB
73.93
28%
-65
- C3 -
1C96
3
ACON_BOVIN
A:
[20-747]
-------------------------------------------------
L
E
K
N
I
D
I
V
R
-
K
R
L
N
R
P
L
T
-
L
S
E
K
I
V
Y
G
H
-
L
D
-
D
P
A
N
Q
-
E
I
E
R
GKTYLR
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
--------
S
G
L
P
K
V
---
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
-----
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
-
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
----------
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
A
D
-
I
A
N
L
A
D
E
F
-
K
D
H
L
V
P
D
----
P
----
G
--
C
H
Y
D
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
------------------------------------
S
V
A
E
-
K
E
G
W
P
-----------
L
---
D
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
-
V
A
K
Q
A
L
A
H
G
L
K
C
K
--
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
-
D
---
R
K
D
I
K
K
G
E
K
N
-----
T
I
V
T
S
Y
N
R
N
F
T
G
R
ND
A
N
P
E
-
T
H
A
-
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
T
-
G
K
D
G
K
K
F
K
L
E
A
--
P
D
A
D
E
L
P
R
A
---------------
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
-
S
G
Q
R
V
A
V
S
P
T
S
Q
R
L
Q
-------
L
L
E
P
F
D
K
W
D
G
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
---------
W
L
K
--------
F
R
G
H
L
D
N
I
S
N
-
N
L
L
I
----
G
A
I
N
I
E
N
R
K
A
N
S
----
V
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
A
S
R
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
--
H
P
V
D
K
L
T
I
Q
G
LK
D
-----
F
A
P
G
K
P
L
--
K
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
-
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
L
Q
Q
16
PsiBlast_PDB
73.81
28%
-67
- C3 -
1B0K
3
ACON_PIG
A:
[20-747]
-------------------------------------------------
L
E
K
N
I
D
I
V
R
-
K
R
L
N
R
P
L
T
-
L
S
E
K
I
V
Y
G
H
-
L
D
-
D
P
A
N
Q
-
E
I
E
R
GKTYLR
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
--------
S
G
L
P
K
V
---
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
-----
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
-
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
----------
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
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C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
A
D
-
I
A
N
L
A
D
E
F
-
K
D
H
L
V
P
D
----
P
----
G
--
C
H
Y
D
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
------------------------------------
S
V
A
E
-
K
E
G
W
P
-----------
L
---
D
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
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S
A
A
-
V
A
K
Q
A
L
A
H
G
L
K
C
K
--
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
-
D
---
R
K
D
I
K
K
G
E
K
N
-----
T
I
V
T
S
Y
N
R
N
F
T
G
R
ND
A
N
P
E
-
T
H
A
-
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
T
-
G
K
D
G
K
K
F
K
L
E
A
--
P
D
A
D
E
L
P
R
A
---------------
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
-
S
G
Q
R
V
D
V
S
P
T
S
Q
R
L
Q
-------
L
L
E
P
F
D
K
W
D
G
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
---------
W
L
K
--------
F
R
G
H
L
D
N
I
S
N
-
N
L
L
I
----
G
A
I
N
I
E
N
R
K
A
N
S
----
V
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
A
S
R
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
--
H
P
V
D
K
L
T
I
Q
G
LK
D
-----
F
A
P
G
K
P
L
--
K
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
-
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
L
Q
Q
18
PsiBlast_PDB
73.70
28%
-67
- C3 -
1B0M
2
ACON_PIG
A:
[20-747]
-------------------------------------------------
L
E
K
N
I
D
I
V
R
-
K
R
L
N
R
P
L
T
-
L
S
E
K
I
V
Y
G
H
-
L
D
-
D
P
A
N
Q
-
E
I
E
R
GKTYLR
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
--------
S
G
L
P
K
V
---
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
-----
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
-
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
----------
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
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C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
A
D
-
I
A
N
L
A
D
E
F
-
K
D
H
L
V
P
D
----
P
----
G
--
C
H
Y
D
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
------------------------------------
S
V
A
E
-
K
E
G
W
P
-----------
L
---
D
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
-
V
A
K
Q
A
L
A
H
G
L
K
C
K
--
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
-
D
---
R
K
D
I
K
K
G
E
K
N
-----
T
I
V
T
S
Y
N
R
N
F
T
G
R
ND
A
N
P
E
-
T
H
A
-
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
T
-
G
K
D
G
K
K
F
K
L
E
A
--
P
D
A
D
E
L
P
R
A
---------------
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
-
S
G
Q
R
V
D
V
S
P
T
S
Q
R
L
Q
-------
L
L
E
P
F
D
K
W
D
G
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
---------
W
L
K
--------
F
R
G
H
L
D
N
I
S
N
-
N
L
L
I
----
G
A
I
N
I
E
N
R
K
A
N
S
----
V
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
Q
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
--
H
P
V
D
K
L
T
I
Q
G
LK
D
-----
F
A
P
G
K
P
L
--
K
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
-
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
L
Q
Q
17
PsiBlast_PDB
73.38
28%
-68
- C3 -
1B0J
2
ACON_PIG
A:
[21-748]
-------------------------------------------------
L
E
K
N
I
D
I
V
R
-
K
R
L
N
R
P
L
T
-
L
S
E
K
I
V
Y
G
H
-
L
D
-
D
P
A
N
Q
-
E
I
E
R
GKTYLR
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
--------
S
G
L
P
K
V
---
A
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
-----
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
K
Y
-
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
----------
Y
P
G
-
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
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C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
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L
K
C
P
K
V
I
G
V
K
L
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G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
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L
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G
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A
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P
G
V
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S
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C
T
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M
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T
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C
N
M
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A
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I
G
A
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V
F
P
Y
N
H
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M
K
K
Y
L
S
K
T
G
R
A
D
-
I
A
N
L
A
D
E
F
-
K
D
H
L
V
P
D
----
P
----
G
--
C
H
Y
D
Q
V
I
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I
N
L
S
E
L
K
P
H
I
N
G
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F
T
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D
L
A
H
P
V
A
E
V
G
------------------------------------
S
V
A
E
-
K
E
G
W
P
-----------
L
---
D
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
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S
A
A
-
V
A
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Q
A
L
A
H
G
L
K
C
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--
S
Q
F
T
I
T
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Q
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A
T
I
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R
D
G
Y
A
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V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
-
D
---
R
K
D
I
K
K
G
E
K
N
-----
T
I
V
T
S
Y
N
R
N
F
T
G
R
ND
A
N
P
E
-
T
H
A
-
F
V
T
S
P
E
I
V
T
A
L
A
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A
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L
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F
N
P
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T
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F
L
T
-
G
K
D
G
K
K
F
K
L
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A
--
P
D
A
D
E
L
P
R
A
---------------
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
-
S
G
Q
R
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D
V
S
P
T
S
Q
R
L
Q
-------
L
L
E
P
F
D
K
W
D
G
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D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
---------
W
L
K
--------
F
R
G
H
L
D
N
I
S
N
-
N
L
L
I
----
G
A
I
N
I
E
N
R
K
A
N
S
----
V
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
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W
V
V
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G
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A
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L
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P
R
H
L
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A
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L
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L
L
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L
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P
A
D
Y
N
K
I
--
H
P
V
D
K
L
T
I
Q
G
LK
D
-----
F
A
P
G
K
P
L
--
K
C
I
I
K
H
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N
G
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L
L
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