@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0547: (2015-12-02 )
MHLFCFGYGYVARFLSKKLLSLSWKVSGTSRNQDVHNTNFFNYDKVNKDTFQDVTHVLVSIPPDGDDALERYGHYFQNTKWLGYLSAASVYGDHAGNWVKEESETKPIESRGKSRLRAEKKWLNSKLPVHIFRLTGIYGPGRNVLVDLQLNKARNVQKEGHFFSRIHVEDISNILFSSMQNIKPGEIYNCADDLPATQSEVVAYAAELLNVSVPEPVEISSLPDHAQSFYLGSKKVSNIKVKRDLGISLVYPNYKVGLENLISNQQAPIERGE
Atome Classification :
(20 SA)
---.......-.-.10........20..--.------.--....30..---.--------------..------...40.....-----.---..50--.--..-----.....60.-..--------.--.-----.-----------.-------.70--....-----.-.-----..----80---------------...----------------......90....--.------------.----------------..100----..-------.....110.......120....----.....130.......140..-----------.-----------.-.-.---.----150---.--.--.---...------..--.160...-------------.----...170.......180----.----..---....190.--.-.....200.......210----.....-.-.--.--220----...--..-....230.......240----.......250.......260.......270.----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---
M
H
L
F
C
F
G
-
Y
-
G
Y
V
A
R
F
L
S
K
K
L
L
S
L
S
--
W
------
K
--VSGTSRNQ---D--------------VH------NTNFFNYDKV-----N---
K
D
T
F
--
Q
--
D
V
-----
T
H
V
L
VSIP-PD--------G--
D
-----
D
-----------
A
-------
L
E
R
--
Y
G
H
Y
-----
F
-Q-----N
T
----
K
----------------
W
L
G
----------------
Y
L
S
A
A
S
VYGDHA--G------------N----------------WVKEE----SE-------TK
P
I
E
S
R
G
K
S
R
L
R
A
E
K
--
K
W
LN----SKL
P
V
H
I
F
R
L
T
GIYGPGR
N
V
-----------
L
-----------
V
-
D
-
L
---
Q
----L-----N--K--A---RNV------QK--EG
H
F
F
S
R
-------------
I
----
H
V
E
D
I
S
N
I
L
F
S
S
M
QNI----K----PG---
E
I
YNCADD--L-PA
T
Q
S
E
V
V
A
Y
A
A
E
L
LNV-----SVPEP-V-E--I--S------SLP--
D
H
-
A
Q
S
FYLGS
K
K
VS
N
I
K
V
K
----
R
DL
G
I
S
L
VYPNYK
V
G
L
E
N
L
ISNQQAPIERGE----
1
PsiBlast_PDB
94.32
41%
-69
- C3 -
3IUS
3
?
A:
[8-285]
-----
L
L
S
F
G
-
H
-
G
Y
T
A
R
V
L
S
R
A
L
A
P
Q
G
--
W
------
R
--
I
I
G
T
S
R
N
P
---
D
--------------
Q
M
------
E
A
I
R
A
S
G
A
E
P
L
L
W
PG
E
---
E
P
S
L
--
D
--
G
V
-----
T
H
L
L
I
S
T
A
-
P
D
SG------
G
--
D
-----
P
-----------
V
-------
L
A
A
--
L
G
D
Q
-----
I
-
A
-----
A
R
AAQF
R
----------------
W
V
G
----------------
Y
L
S
T
T
A
V
Y
G
D
H
D
--
G
------------
A
----------------
W
V
D
E
T
----
T
P
-------
L
T
P
T
A
A
R
G
R
W
R
V
M
A
E
Q
--
Q
W
Q
A
V---
P
N
L
P
L
H
V
F
R
L
A
G
I
Y
G
P
G
R
G
P
-----------
F
-----------
S
-
K
-
L
---
G
----
K
-----
G
--
G
--
I
---
R
R
I
------
I
K
--
P
G
Q
V
F
S
R
-------------
I
----
H
V
E
D
I
A
Q
V
L
A
A
S
M
A
R
P
----
D
----
P
G
---
A
V
Y
N
V
C
D
D
--
E
-
P
V
P
P
Q
D
V
I
A
Y
A
A
E
L
Q
G
L
-----
P
L
P
P
A
-
V
-
D
--
F
DK
A
------
D
L
T
--
P
M
-
A
R
S
F
Y
S
E
N
K
R
V
R
N
D
R
I
K
----
E
E
L
G
V
R
L
K
Y
P
N
Y
R
V
G
L
E
A
L
Q
A
D
A
E
T
----------
22
HHSearch
86.41
39%
-61
- C3 -
3IUS
3
?
A:
[5-283]
---
T
G
T
L
L
S
F
G
H
-
G
Y
T
A
R
V
L
S
R
A
L
A
P
Q
G
--
W
------
R
--
I
I
G
T
S
R
N
P
---
D
--------------
Q
M
------
E
A
I
R
A
S
G
A
E
P
-----
L
L
W
-
P
G
E
E
--
P
--
S
L
-----
D
G
V
T
H
L
L
I
-
S
T
--------
A
--
P
D
SGG-
D
-----------
P
-------
V
L
A
A
L
G
D
Q
I
A
A
R
--
A
-
A
-----
Q
F
----
R
----------------
W
V
G
----------------
Y
L
S
T
T
A
V
Y
G
D
H
D
--
G
------------
A
----------------
W
V
D
E
T
----
T
P
-------
L
T
P
T
A
A
R
G
R
W
R
V
M
A
E
Q
--
Q
W
Q
A
V---
P
N
L
P
L
H
V
F
R
L
A
G
I
Y
G
P
G
R
G
P
-----------
F
-----------
S
-
K
-
L
---
G
----
K
-----
G
--
G
--
I
---
R
R
I
------
I
K
--
P
G
Q
V
F
S
R
-------------
I
----
H
V
E
D
I
A
Q
V
L
A
A
S
M
A
R
P
----
D
----
P
G
---
A
V
Y
N
V
C
D
D
--
E
-
P
V
P
P
Q
D
V
I
A
Y
A
A
E
L
Q
G
L
-----
P
L
P
P
A
-
V
-
D
--
F
--
D
KA----
D
L
T
--
P
M
-
A
R
S
F
Y
S
E
N
K
R
V
R
N
D
R
I
K
----
E
E
L
G
V
R
L
K
Y
P
N
Y
R
V
G
L
E
A
L
Q
A
D
A
E
T
----------
42
Fugue
76.80
20%
-81
- C3 -
3GPI
3
?
A:
[2-279]
-SL
S
K
I
L
I
A
G
-
C
-
G
D
L
G
L
E
L
A
R
R
L
T
A
Q
G
--
H
------
E
--
V
T
G
L
R
R
S
A
---
Q
P
M
P
AG
V
Q
-------
T
L
------
I
A
D
V
T
R
P
D
T
L
-----
A
---
S
I
V
H
--
L
--
R
P
-----
E
I
L
V
Y
C
V
A
-
A
S
--------
E
Y
S
L
-----
S
-----------
Y
-------
V
E
G
--
L
R
N
T
-----
L
-
S
A
L
EGA
P
L
----
Q
----------------
H
V
F
----------------
F
V
S
S
T
G
V
Y
G
Q
E
V
--
E
------------
E
----------------
W
L
D
E
D
----
T
P
-------
P
I
A
K
D
F
S
G
K
R
M
L
E
A
E
A
--
L
L
A
A
------
Y
S
S
T
I
L
R
F
S
G
I
Y
G
P
G
R
L
R
-----------
M
-----------
I
-
R
-
Q
--------
A
-----
Q
--
T
--
P
---
E
Q
W
------
P
A
--
R
N
A
W
T
N
R
-------------
I
----
H
R
D
D
G
A
A
F
I
A
Y
L
I
Q
Q
R
SHA-
V
----
P
E
---
R
L
Y
I
V
T
D
N
--
Q
-
P
L
P
V
H
D
L
L
R
W
L
A
D
R
Q
G
I
-----
A
---------------------
Y
P
--
A
G
-
A
T
P
P
V
Q
G
N
K
K
L
S
N
A
R
L
L
----
A
-
S
G
Y
Q
L
I
Y
P
D
Y
V
S
G
Y
G
A
L
L
A
A
M
R
E
----------
38
HHSearch
75.11
20%
-73
- C3 -
3GPI
3
?
A:
[4-279]
---
S
K
I
L
I
A
G
-
C
-
G
D
L
G
L
E
L
A
R
R
L
T
A
Q
G
--
H
------
E
--
V
T
G
L
R
R
S
A
---
Q
P
M
P
A----------
G
V
------
Q
T
L
I
A
D
V
T
R
P
-----
D
TL-
A
S
I
V
--
H
L-
R
P
-----
E
I
L
V
Y
C
V
A
-
A
S
--------
E
--
Y
-----
S
LS---------
Y
-------
V
E
G
--
L
R
N
T
L
S
A
L
E
G
-
A
-----
P
L
----
Q
----------------
H
V
F
----------------
F
V
S
S
T
G
V
Y
G
Q
E
V
--
E
------------
E
----------------
W
L
D
E
D
----
T
P
-------
P
I
A
K
D
F
S
G
K
R
M
L
E
A
E
A
--
L
L
A
------
A
Y
S
S
T
I
L
R
F
S
G
I
Y
G
P
G
R
L
R
-----------
M
-----------
I
-
R
-
Q
---
A
----
Q
--------
T
--
P
---
E
Q
W
------
P
A
--
R
N
A
W
T
N
R
-------------
I
----
H
R
D
D
G
A
A
F
I
A
Y
L
I
Q
Q
R
----
S
HAV-
P
E
---
R
L
Y
I
V
T
D
N
--
Q
-
P
L
P
V
H
D
L
L
R
W
L
A
D
R
Q
G
I
-----
A
Y
P
A
G
-
A
-
T
----------------------
P
P
V
Q
G
N
K
K
L
S
N
A
R
L
L
-----
A
S
G
Y
Q
L
I
Y
P
D
Y
V
S
G
Y
G
A
L
L
A
A
M
R
E
----------
3
PsiBlast_PDB
70.83
22%
-61
- C3 -
2C20
2
?
A:
[5-316]
-----
L
I
C
G
G
-
A
-
G
Y
I
G
S
H
A
V
K
K
L
V
D
E
G
--
L
------
S
--
V
V
V
V
D
N
L
Q
---
T
--------------
G
H
EDAITE
G
A
K
F
Y
N
G
D
L
R
-----
D
---
K
A
F
L
--
R
--
D
V
F
T
Q
E
N
I
E
A
V
M
H
F
A
-
A
D
--------
S
L
V
G
-----
V
-----------
S
-------
M
E
K
--
P
L
Q
Y
-----
Y
-
N
-----
N
N
----
V
----------------
Y
G
A
L
C
L
L
E
V
M
D
E
F
KVD
K
F
I
F
S
S
T
A
A
T
Y
G
E
V
D
--
V
------------
D
----------------
L
I
T
E
E
----
T
M
-------
T
N
P
T
N
T
Y
G
E
T
K
L
A
I
E
K
M
L
H
W
Y
S
Q
A
--
S
N
L
R
Y
K
I
F
R
Y
F
N
V
A
G
A
T
P
N
G
IIGEDHRPETH
L
-----------
I
-
P
-
L
---
V
----
L
-----
Q
--
V
--
A
---
L
G
Q
------
R
E
--
K
I
M
M
F
G
D
DYNTPDG
T
C
I
R
D
Y
I
----
H
V
E
D
L
V
A
A
H
F
L
G
L
K
D
L
----
Q
----
N
G
G
E
S
D
F
Y
N
L
G
N
G
--
N
-
G
F
S
V
K
E
I
V
D
A
V
R
E
V
T
N
H
-----
E
I
P
A
E
-
V
-
A
--
P
--
R
------
R
A
G
--
D
P
-
A
R
L
V
------
A
S
S
Q
K
A
K
----
E
K
L
G
W
D
P
R
Y
V
N
V
K
T
I
I
E
H
A
W
N
W
H
Q
K
Q
P
N
G
Y
E
----
36
HHSearch
69.49
15%
-83
- C3 -
2YDY
4
MAT2B_HUMAN
A:
[3-298]
---
R
R
V
L
V
T
G
A
T
-
G
L
L
G
R
A
V
H
K
E
F
Q
Q
N
N
--
W
------
H
--
A
V
G
C
G
---------------------------------------------V--
H
H
I
I
--
H
D
F
Q
P
-----
H
V
I
V
H
C
A
-----------------------------------------
V
D
A
--
S
G
N
L
A
K
E
A
-
A
-
A
-----
V
G
----
A
----------------
F
L
I
----------------
Y
I
S
S
D
Y
V
F
D
G
T
N
---------------
P
----------------
P
Y
R
E
E
----
D
I
-------
P
A
P
L
N
L
Y
G
K
T
K
L
D
G
E
K
--
A
V
L
E
----
N
N
L
G
A
A
V
L
R
I
P
I
L
Y
G
E
V
E
K
L
EES
A
-------
V
-----------
T
-
V
-
M
---
F
D
K
V
-
Q
F
----
S
--
N
--
K
---
S
A
N
------
M
D
--
H
W
Q
Q
R
F
P
-------------
T
----
H
V
K
D
V
A
T
V
C
R
Q
L
A
E
K
R
M
LDP
S
----
I
K
---
G
T
F
H
W
S
G
N
--
E
-
Q
M
T
K
Y
E
M
A
C
A
I
A
D
A
F
N
L
-----
P
S
S
H
L
-
R
-
P
--
I
--
T
------
D
-
S
--
P
V
-
L
G
A
Q
R
P
R
N
A
Q
L
D
C
S
K
L
E
-----
T
L
G
I
G
Q
R
T
-
P
F
R
I
G
I
K
E
S
L
W
P
F
L
I
----------
33
HHSearch
68.89
17%
-65
* C3 *
2HUN
1
?
A:
[4-316]
---
M
K
L
L
V
T
G
G
M
-
G
F
I
G
S
N
F
I
R
Y
I
L
E
K
H
P
D
W
------
E
--
V
I
N
I
D
K
L
G
---
Y
GSNPANLKDLEDDP
R
Y
------
T
F
V
K
G
D
V
A
D
Y
-----
E
L
V
-
K
E
L
V
--
R
--
K
V
-----
D
G
V
V
H
L
A
A
-
E
S
--------
H
--
V
D
R
S
I
S
S
P
E
I
F
L
H
S----
N
-------
V
I
G
--
T
Y
T
L
L
E
S
I
R
R
E
N
-----
P
E
----
V
----------------
R
F
V
----------------
H
V
S
T
D
E
V
Y
G
D
I
L
--
K
------------
G
----------------
S
F
T
E
N
----
D
R
-------
L
M
P
S
S
P
Y
S
A
T
K
A
A
S
D
M
--
L
V
L
G
W
T
R
T
Y
N
L
N
A
S
I
T
R
C
T
N
N
Y
G
P
Y
Q
F
P
EK---------
L
-----------
I
P
K
-
T
---
I
I
R
A
-
S
L
G---
L
--
K
--
I
---
P
I
Y
------
G
T
-----
V
R
D
W
-------------
L
----
Y
V
E
D
H
V
R
A
I
E
L
V
L
L
K
G
----
E
----
S
R
---
E
I
Y
N
I
S
A
G
--
E
-
E
K
T
N
L
E
V
V
K
I
I
L
R
L
M
G
K
-----
G
E
E
L
I
-
E
-
L
-----
V
-----------
E
D
--
R
P
G
H
D
L
R
Y
S
L
D
S
W
K
I
T
----
R
D
L
K
W
R
P
K
Y
-
T
F
D
E
G
I
K
K
T
I
D
W
Y
L
K
N
E
W
W
W
K
----
39
HHSearch
68.53
21%
-55
- C3 -
2C20
2
?
A:
[2-326]
---
N
S
I
L
I
C
G
G
A
-
G
Y
I
G
S
H
A
V
K
K
L
V
D
E
G
--
L
------
S
--
V
V
V
V
D
N
L
Q
---
T
GHEDAITE------
G
A
------
K
F
Y
N
G
D
L
R
D
K
-----
A
F
L
-
R
D
V
F
T
Q
E
--
N
I
-----
E
A
V
M
H
F
A
A
-
D
S
--------
L
--
V
G
V
S
M
E
K
-----------
P
L
Q
Y
Y
N
N
N
V
Y
G
--
A
L
C
L
L
E
V
M
D
E
-
F
-----
K
V
----
D
----------------
K
F
I
----------------
F
S
S
T
A
A
T
Y
G
E
V
D
--
V
------------
D
----------------
L
I
T
E
E
----
T
M
-------
T
N
P
T
N
T
Y
G
E
T
K
L
A
I
E
K
--
M
L
H
W
Y
S
Q
A
S
N
L
R
Y
K
I
F
R
Y
F
N
V
A
G
A
T
P
N
G
-----------
I
IGEDHRPETH
L
I
-
P
-
L
---
V
L
Q
V
A
L
G----
Q
--
R
E
K
I
---
M
M
F
G
DDYNT
P
D
--
G
T
C
I
R
D
Y
-------------
I
----
H
V
E
D
L
V
A
A
H
F
L
G
L
K
D
L
Q
N
G-
G
----
E
S
---
D
F
Y
N
L
G
N
G
--
N
-
G
F
S
V
K
E
I
V
D
A
V
R
E
V
T
N
H
-----
E
I
P
A
E
-
V
-
A
-----
P
------------
R
--
R
A
G
D
P
A
R
L
V
A
S
S
Q
K
A
K
----
E
K
L
G
W
D
P
R
Y
V
N
V
K
T
I
I
E
H
A
W
N
W
H
Q
K
Q
P
N
G
Y
E
----
24
HHSearch
67.76
16%
-62
- C3 -
2PK3
2
RMD_ANETH
A:
[13-320]
---
M
R
A
L
I
T
G
V
A
-
G
F
V
G
K
Y
L
A
N
H
L
T
E
Q
N
--
V
------
E
--
V
F
G
T
S
R
N
N
---
E
A
K
L
P
----------
N
V
------
E
M
I
S
L
D
I
M
D
S
-----
Q
R
V
-
K
K
V
I
--
S
D
I
K
P
-----
D
Y
I
F
H
L
A
A
-
K
S
--------
S
--
V
K
D
S
W
L
N
K
K
G
T
F
S
T
----
N
-------
V
F
G
--
T
L
H
V
L
D
A
V
R
D
-
S
N----
L
D
----
C
----------------
R
I
L
----------------
T
I
G
S
S
E
E
Y
G
M
I
L
PE
E
------------
S
----------------
P
V
S
E
E
----
N
Q
-------
L
R
P
M
S
P
Y
G
V
S
K
A
S
V
G
M
--
L
A
R
Q
Y
V
K
A
Y
G
M
D
I
I
H
T
R
T
F
N
H
I
G
P
G
Q
S
L
GF---------
V
-----------
T
-
Q
-
D
---
F
A
K
Q
I
V
D
I
E
M
E
K
QE
P
--
I
---
I
K
V
------
G
N
--
L
E
A
V
R
D
F
-------------
T
----
D
V
R
D
I
V
Q
A
Y
W
L
L
S
Q
Y
G
----
K
----
T
G
---
D
V
Y
N
V
C
S
G
--
I
-
G
T
R
I
Q
D
V
L
D
L
L
L
A
M
A
N
V
-----
K
I
D
T
E
-
L
-
N
-----
P
--------
L
--
Q
L
--
R
P
S
E
V
P
T
L
I
G
S
N
K
R
L
K
----
D
S
T
G
W
K
P
R
I
-
P
L
E
K
S
L
F
E
I
L
Q
S
Y
R
Q
A
---------
26
HHSearch
66.56
16%
-67
- C3 -
1R6D
2
?
A:
[1-315]
---
M
R
L
L
V
T
G
G
A
-
G
F
I
G
S
H
F
V
R
Q
L
L
A
G
A
--
Y
PDVPAD
E
--
V
I
V
L
D
S
L
T
---
Y
AGNRANLAPVDADP
R
L
------
R
F
V
H
G
D
I
R
D
A
-----
G
L
L
-
A
R
E
L
--
R
--
G
V
-----
D
A
I
V
H
F
A
A
-
E
S
--------
H
--
V
D
R
S
I
-
A
GA
S
V
F
T
E
T
---
N
-------
V
Q
G
--
T
Q
T
L
L
Q
C
A
V
D
-
A
-----
G
V
----
G
----------------
R
V
V
----------------
H
V
S
T
N
Q
V
Y
G
S
I
D
--
S
------------
G
----------------
S
W
T
E
S
----
S
P
-------
L
E
P
N
S
P
Y
A
A
S
K
A
G
S
D
L
--
V
A
R
A
Y
H
R
T
Y
G
L
D
V
R
I
T
R
C
C
N
N
Y
G
P
Y
Q
H
P
EK---------
L
-----------
I
-
P
L
F
---
V
T
N
L
-
L
D
G---
G
--
T
--
L
---
P
L
Y
------
G
D
--
G
A
N
V
R
E
W
-------------
V
----
H
T
D
D
H
C
R
G
I
A
L
V
L
A
G
G
----
R
----
A
G
---
E
I
Y
H
I
G
G
G
--
L
-
E
L
T
N
R
E
L
T
G
I
L
L
D
S
L
G
A
-----
D
W
S
S
V
-
R
-
K
-----
V
--------
A
--
D
---
R
K
G
H
D
L
R
Y
S
L
D
G
G
K
I
E
----
R
E
L
G
Y
R
P
Q
V
-
S
F
A
D
G
L
A
R
T
V
R
W
Y
R
E
N
R
G
W
W
E
----
37
HHSearch
65.34
14%
-60
- C3 -
1OC2
4
?
A:
[5-327]
---
K
N
I
I
V
T
G
G
A
-
G
F
I
G
S
N
F
V
H
Y
V
Y
N
N
H
--
P
------
D
V
H
V
T
V
L
D
K
L
T
---
Y
AGNKANLEAILGD-
R
V
------
E
L
V
V
G
D
I
A
D
A
-----
E
L
V
-
D
K
L
A
--
A
--
K
A
-----
D
A
I
V
H
Y
A
A
-
E
S
--------
H
--
N
D
N
S
L
N
D
P
S
P
F
I
H
T----
N
-------
F
I
G
--
T
Y
T
L
L
E
A
A
-
R
-
K
-----
Y
D
----
I
----------------
R
F
H
----------------
H
V
S
T
D
E
V
Y
G
D
L
P
--
L
REDLPGHGEGPG
E
----------------
K
F
T
A
E
----
T
N
-------
Y
N
P
S
S
P
Y
S
S
T
K
A
A
S
D
L
--
I
V
K
A
W
V
R
S
F
G
V
K
A
T
I
S
N
C
S
N
N
Y
G
P
Y
Q
H
I
EK---------
F
-----------
I
-
P
-
R
Q
--
I
T
N
I
-
L
A
----
G
I
-
K
--
P
---
K
L
Y
------
G
E
--
G
K
N
V
R
D
W
-------------
I
----
H
T
N
D
H
S
T
G
V
W
A
I
L
T
K
G
----
R
----
M
G
---
E
T
Y
L
I
G
A
D
--
G
-
E
K
N
N
K
E
V
L
E
L
I
L
E
K
M
G
Q
-----
P
K
D
A
Y
-
D
-
H
-----
V
--------
T
--
D
---
R
A
G
H
D
L
R
Y
A
I
D
A
S
K
L
R
----
D
E
L
G
W
T
P
Q
F
T
D
F
S
E
G
L
E
E
T
I
Q
W
Y
T
D
N
Q
D
W
W
K
----
40
HHSearch
64.92
18%
-62
- C3 -
2PZM
4
?
A:
[21-319]
---
M
R
I
L
I
T
G
G
A
-
G
C
L
G
S
N
L
I
E
H
W
L
P
Q
G
--
H
------
E
--
I
L
V
I
D
N
F
A
---
T
GKREVLPPVA----
G
L
------
S
V
I
E
G
S
V
T
D
A
-----
G
L
L
-
E
R
A
F
--
D
S
F
K
P
-----
T
H
V
V
H
S
A
A
-
A
Y
--------
K
--
D
PD---
D
W
A
E
D
A
A
T
----
N
-------
V
Q
G
--
S
I
N
V
A
K
A
A
S
K
-
A
-----
G
V
----
K
----------------
R
L
L
----------------
N
F
Q
T
A
L
C
Y
G
R
P
A
--
T
------------
V
----------------
P
I
P
I
D
----
S
P
-------
T
A
P
F
T
S
Y
G
I
S
K
T
A
G
E
A
--
F
L
M
M
----
S
D
V
P
V
V
S
L
R
L
A
N
V
T
G
P
R
L
A
I
G
P
---------
I
-----------
P
-
T
-
F
---
Y
K
R
L
-
K
-----
A
--
G
--
Q
---
K
C
F
-------
C
--
S
D
T
V
R
D
F
-------------
L
----
D
M
S
D
F
L
A
I
A
D
L
S
L
Q
E
G
----
R
----
P
T
---
G
V
F
N
V
S
T
G
--
E
-
G
H
S
I
K
E
V
F
D
V
V
L
D
Y
V
G
A
-----
T
L
A
E
P
-
V
-
P
--
V
--
V
--------
A
--
P
---
G
A
D
D
V
P
S
V
V
L
D
P
S
K
T
E
----
T
E
F
G
W
K
A
K
V
-
D
F
K
D
T
I
T
G
Q
L
A
W
Y
D
K
Y
G
V
T
D
I
----
43
Fugue
64.68
18%
-59
- C3 -
4NDN
1
MAT2B_HUMAN
F:
[15-323]
IPN
R
R
V
L
V
T
G
-
A
T
G
L
L
G
R
A
V
H
K
E
F
Q
Q
N
N
--
W
------
H
--
A
V
G
C
G
F
R
R
ARP
K
--------------
F
E
------
Q
V
N
L
L
D
S
N
A
V
-----
H
---
H
I
I
H
--
D
--
F
Q
-----
P
H
V
I
V
H
C
A
-
A
E
RRPDVDAA
S
--
Q
-----
L
-----------
N
-------
V
D
A
--
S
G
N
L
-----
A
-
K
-----
E
A
----
A
----------------
A
V
G
AFLI------------
Y
I
S
S
D
Y
V
F
D
G
T
N
--
P
------------
P
----------------
Y
-
R
E
E
----
D
I
-------
P
A
P
L
N
L
Y
G
K
T
K
L
D
G
E
K
--
A
V
L
E
----
N
N
L
G
A
A
V
L
R
I
P
I
L
Y
G
E
V
E
K
L
-----------
E
ESA--------
V
-
T
-
V
---
M
----
F
-----
D
--
K
--
V
QFS
N
K
S
------
A
N
--
M
D
H
W
Q
Q
R
FP-----------
T
----
H
V
K
D
V
A
T
V
C
R
Q
L
A
E
K
R
----
M
LDPS
I
K
---
G
T
F
H
W
S
G
N
--
E
-
Q
M
T
K
Y
E
M
A
C
A
I
A
D
A
F
N
L
-----
P
S
S
H
L
-
R
-
P
--
I
--
T
------
D
S
P
---------
V
L
G
A
Q
R
P
R
N
A
Q
L
D
CSKL
E
T
L
G
I
G
Q
R
T
P
-
F
R
I
G
I
K
E
S
L
W
P
F
L
I
D
K
R
W
R
Q
TVFH
31
HHSearch
64.41
13%
-59
- C3 -
3KO8
2
?
A:
[1-310]
---
M
R
I
V
V
T
G
G
A
-
G
F
I
G
S
H
L
V
D
K
L
V
E
L
G
--
Y
------
E
--
V
V
V
V
D
N
L
S
---
S
GRREFVNP------
S
A
------
E
L
H
V
R
D
L
K
D
Y
-----
S
---
W
G
A
G
--
I
--
K
G
-----
D
V
V
F
H
F
A
A
-
N
P
--------
E
--
V
RLSTT
E
P
I
V
H
F
N
E
----
N
-------
V
V
A
--
T
F
N
V
L
E
W
A
R
Q
-
T
-----
G
V
----
R
----------------
T
V
V
----------------
F
A
S
S
S
T
V
Y
G
D
A
D
--
V
------------
I
----------------
P
T
P
E
E
----
E
P
-------
Y
K
P
I
S
V
Y
G
A
A
K
A
A
G
E
V
--
M
C
A
T
Y
A
R
L
F
G
V
R
C
L
A
V
R
Y
A
N
V
V
G
P
R
L
R
H
G
V
---------
I
-----------
Y
-
D
-
F
---
I
M
K
L
-
R
-----
R
N-
P
N
V
L
---
E
V
L
------------
Q
R
K
S
Y
-------------
L
----
Y
V
R
D
A
V
E
A
T
L
A
A
W
K
K
F
E
E
M
D
A
----
P
F
---
L
A
L
N
V
G
N
V
--
D
-
A
V
R
V
L
D
I
A
Q
I
V
A
E
V
L
G
L
-----
R
P
E
I
R
-
L
V------------------------
G
D
V
K
Y
M
T
L
A
V
T
K
L
M
----
K
L
T
G
W
R
P
T
M
-
T
S
A
E
A
V
K
K
T
A
E
D
L
A
K
E
L
W
-------
28
HHSearch
64.28
14%
-61
- C3 -
1ORR
2
RFBE_SALTI
A:
[2-339]
---
A
K
L
L
I
T
G
G
C
-
G
F
L
G
S
N
L
A
S
F
A
L
S
Q
G
--
I
------
D
--
L
I
V
F
D
N
L
S
---
R
KG
A
T
D
N
L
H
W
L
S
S
L
G
N
F
------
E
F
V
H
G
D
I
R
N
K
-----
N
D
V
-
T
R
L
I
--
T
K
Y
M
P
-----
D
S
C
F
H
L
A
G
-
Q
V
--------
A
--
M
T
T
S
I
D
N
P
C
M
D
F
E
I
----
N
-------
V
G
G
--
T
L
N
L
L
E
A
V
R
Q
-
Y
N----
S
N
----
C
----------------
N
I
I
----------------
Y
S
S
T
N
K
V
Y
G
D
L
E
--
Q
------------
Y
K
Y
N
E
T
ETRYTCVDKPN
G
Y
D
E
S
----
T
Q
-------
L
D
F
H
S
P
Y
G
C
S
K
G
A
A
D
Q
--
Y
M
L
D
Y
A
R
I
F
G
L
N
T
V
V
F
R
H
S
S
M
Y
G
G
R
Q
F
A
TYDQG------
W
-----------
V
-
G
-
W
---
F
C
Q
K
A
V
E
I
K
N
G
I
NK
P
--
F
---
T
I
S
------
G
N
--
G
K
Q
V
R
D
V
-------------
L
----
H
A
E
D
M
I
S
L
Y
F
T
A
L
A
N
V
SK--
I
----
R
G
---
N
A
F
N
I
G
G
T
IV
N
-
S
L
S
L
L
E
L
F
K
L
L
E
D
Y
C
N
I
-----
D
M
R
F
T
-
N
-
L
-----
P
------------
V
--
R
E
S
D
Q
R
V
F
V
A
D
I
K
K
I
T
----
N
A
I
D
W
S
P
K
V
-
S
A
K
D
G
V
Q
K
M
Y
D
W
T
S
S
I
---------
41
HHSearch
64.21
13%
-68
- C3 -
1N2S
2
RMLD_SALTY
A:
[1-297]
---
M
N
I
L
L
F
G
K
T
-
G
Q
V
G
W
E
L
Q
R
S
L
A
P
V
G
--
N
---------
L
I
A
L
D
V
H
S
--------------------------
K
E
F
C
G
D
F
S
N
P
-----
K
G
V
-
A
E
T
V
--
R
K
L
R
P
-----
D
V
I
V
N
A
A
A
-
H
T
--------
A
--
V
D
K
A
E
S
E
-----------
P
E
L
A
Q
L
L
N
A
T
S
--
V
E
A
I
A
K
A
A
-
N
-
E
-----
T
G
----
A
----------------
W
V
V
----------------
H
Y
S
T
D
Y
V
F
P
G
T
G
--
D
------------
I
----------------
P
W
Q
E
T
----
D
A
-------
T
S
P
L
N
V
Y
G
K
T
K
L
A
G
E
K
--
A
L
Q
D
----
N
C
P
K
H
L
I
F
R
T
S
W
V
Y
A
G
K
G
N
N
-----------
F
-----------
A
-
K
-
T
---
M
L
R
L
A
K
-----
E
R
Q
T
--
L
---
S
V
I
------
N
D
Q
Y
G
A
P
T
G
A
E
-------------
L
----
L
A
D
C
T
A
H
A
I
R
V
A
L
N
K
P
----
E
----
V
A
---
G
L
Y
H
L
V
A
G
--
G
-
T
T
T
W
H
D
Y
A
A
L
V
F
D
E
A
R
K
-----
A
G
I
T
L
-
A
-
L
T
E
L
--
N
------
A
V
P
TS
A
Y
P
T
P
A
S
R
P
G
N
S
R
L
N
T
E
K
F
Q
----
R
N
F
D
L
I
L
P
--
Q
W
E
L
G
V
K
R
M
L
T
E
M
F
T
T
T
T
-------
32
HHSearch
63.33
15%
-64
- C3 -
1VL0
2
?
A:
[13-292]
---
M
K
I
L
I
T
G
A
N
-
G
Q
L
G
R
E
I
Q
K
Q
L
K
G
K
N
--
V
------
E
--
V
I
P
T
D
V
Q
------------------------------
D
L
D
I
T
N
V
-----
L
A
V
-
N
K
F
F
--
N
E
K
K
P
-----
N
V
V
I
N
C
A
A
-
H
T
--------
A
--
V
D
----
K
C
E
E
Q
Y
D
L
A
Y
K
I
N
-------
A
I
G
--
P
K
N
L
A
A
A
A
-
Y
-
S
-----
V
G
----
A
----------------
E
I
V
----------------
Q
I
S
T
D
Y
V
F
D
G
E
A
--
K
------------
E
----------------
P
I
T
E
F
----
D
E
-------
V
N
P
Q
S
A
Y
G
K
T
K
L
E
G
E
N
--
F
V
K
A
----
L
N
P
K
Y
Y
I
V
R
T
A
W
L
Y
G
D
G
N
N
F
-----------
V
-----------
K
-
T
-
M
---
I
N
L
G
-
K
-----
T
--
H
--
D
---
E
L
K
------
V
V
--
H
D
Q
V
G
T
P
-------------
T
----
S
T
V
D
L
A
R
V
V
L
K
V
I
D
E
K
---------
N
Y
---
G
T
F
H
C
T
C
K
--
G
-
I
C
S
W
Y
D
F
A
V
E
I
F
R
L
T
G
I
-----
D
V
K
V
T
-
P
-
C
-----
T
------
T
-
E
--
E
F
P
R
P
A
K
R
P
K
Y
S
V
L
R
N
Y
M
L
E
----
L
T
T
G
D
I
T
-
R
-
E
W
K
E
S
L
K
E
Y
I
D
L
L
Q
M
----------
34
HHSearch
63.05
14%
-77
- C3 -
2X4G
-
?
A:
[13-338]
---
V
K
Y
A
V
L
G
A
T
-
G
L
L
G
H
H
A
A
R
A
I
R
A
A
G
--
H
------
D
--
L
V
L
I
H
R
P
S
---
S
QIQRLAYL------
E
P
------
E
C
R
V
A
E
M
L
D
H
-----
A
G
L
-
E
R
A
L
--
R
--
G
L
-----
D
G
V
I
F
S
-----------------------E
E
V
A
S
------
A
-------
L
G
Q
--
T
N
P
F
Y
A
A
C
L
Q
-
A
-----
R
V
----
P
----------------
R
I
L
----------------
Y
V
G
S
A
Y
A
M
P
R
H
P
--
Q
G-----------
L
----------------
P
G
H
E
G
LFYD
S
L
-------
P
S
G
K
S
S
Y
V
L
C
K
W
A
L
D
E
--
Q
A
R
E
Q
A
R
-
N
G
L
P
V
V
I
G
I
P
G
M
V
L
G
E
L
D
I
G
PT---------
T
-----------
G
-
R
-
V
I
T
A
I
----
G
-----
N
--
G
--
E
---
M
T
H
-------
Y
--
V
A
G
Q
R
N
V
-------------
I
----
D
A
A
E
A
G
R
G
L
L
M
A
L
E
R
G
----
R
----
I
G
---
E
R
Y
L
L
T
G
H
----
N
L
E
M
A
D
L
T
R
R
I
A
E
L
L
G
Q
-----
P
A
P
Q
P
-
M
-
S
--
M
--
A
M
A
R
A
L
A
T
L
G
--
R
L
---
E
V
M
A
G
G
Q
F
L
D
G
R
K
A
R
----
E
E
L
G
F
F
S
T
T
-
A
L
D
D
T
L
L
R
A
I
D
W
F
R
D
N
G
Y
F
N
-----
47
Fugue
61.01
16%
-53
- C3 -
1N2S
2
RMLD_SALTY
A:
[1-298]
---
M
N
I
L
L
F
G
-
K
T
G
Q
V
G
W
E
L
Q
R
S
L
A
P
-
V
--
G
------
N
--
L
I
A
L
D
V
H
S
---
K
--------------
E
F
------
C
G
D
F
S
N
P
K
G
V
-----
A
---
E
T
V
R
--
K
--
L
R
-----
P
D
V
I
V
N
A
A
A
H
T
--------
A
--
V
-----
D
-----------
K
-------
A
E
S
--
E
P
E
L
-----
A
-
Q
-----
L
L
----
N
A
T
S
V
E
A
I
A
K
A
A
N
E
T
G
A
W
V
V
----------------
H
Y
S
T
D
Y
V
F
P
G
T
G
--
D
------------
I
----------------
P
W
Q
E
T
----
D
A
-------
T
S
P
L
N
V
Y
G
K
T
K
L
A
G
E
K
--
A
L
Q
D
----
N
C
P
K
H
L
I
F
R
T
S
W
V
Y
A
G
K
G
N
N
-----------
F
-----------
A
-
K
-
T
---
M
----
L
-----
R
--
L
--
A
---
K
E
R
------
Q
T
--
L
S
V
I
N
D
Q
-------------
Y
G
A
PT
G
A
E
L
L
A
D
C
T
A
H
A
I
R
V
A
----
L
N
K
PE
V
A
---
G
L
Y
H
L
V
A
G
--
G
-
T
T
T
W
H
D
Y
A
A
L
V
F
D
E
A
R
K
A
GITL
A
L
T
E
L
-
N
-
A
--
V
--
P
------
T
S
A
--
Y
P
-
T
P
A
S
R
P
G
N
S
R
L
N
T
E
K
F
Q
----
R
N
F
D
L
I
L
--
P
Q
W
E
L
G
V
K
R
M
L
T
E
M
F
T
T
T
T
-------
23
HHSearch
60.94
15%
-62
- C3 -
2BLL
-
ARNA_ECOLI
A:
[316-655]
---
M
R
V
L
I
L
G
V
N
-
G
F
I
G
N
H
L
T
E
R
L
L
R
E
D
H-
Y
------
E
--
V
Y
G
L
D
I
G
S
---
D
AISRFLNHP-----
H
F
------
H
F
V
E
G
D
I
S
I
H
-----
S
E
W
I
E
Y
H
V
--
K
--
K
C
-----
D
V
V
L
P
L
V
A
-
I
A
--------
T
--
P
I
E
Y
T
R
N
P
L
R
V
F
E
L
----
D
-------
F
E
E
--
N
L
R
I
I
R
Y
C
-
V
-
K
-----
Y
R
----
K
----------------
R
I
I
----------------
F
P
S
T
S
E
V
Y
G
M
C
S
--
D
------------
K
----------------
Y
F
D
E
D
----
H
S
N
L
I
V
G
P
V
N
K
P
R
W
I
Y
S
V
S
K
Q
L
L
D
R
--
V
I
W
A
Y
G
E
K
E
G
L
Q
F
T
L
F
R
P
F
N
W
M
G
P
R
L
D
N
-----------
L
NAARIGSS
R
A
I
T
-
Q
-
L
---
I
L
N
L
-
V
E
----
G
S
-
P
--
I
---
K
L
I
------
D
G
--
G
K
Q
K
R
C
F
-------------
T
----
D
I
R
D
G
I
E
A
L
Y
R
I
I
E
N
A
GNR-
C
----
D
G
---
E
I
I
N
I
G
N
P
--
E
N
E
A
S
I
E
E
L
G
E
M
L
L
A
S
F
E
K
-----
H
P
L
R
H
H
F
-
P
--
P
--
F
AGF---
R
V
V
----------
V
E
H
R
K
P
S
I
R
N
A
H
----
R
C
L
D
W
E
P
K
I
-
D
M
Q
E
T
I
D
E
T
L
D
F
F
L
R
T
V
D
L
T
D
----