@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0549: (2015-12-02 )
MIILITNDDGFESEGIKLLKEVARNFASEIWIVAPDTDRSGAARSLDHPVKQSIRINQHNEREFSVSGTPADCVIIALNKIMDKKPDLVLSGVNIGSNVGDDVCYSGTIGAVMEGAARSIPSIALSQAYHGGINWYNTKIFAPKVIAKLVKVGWPKNIAMSINFSATEKVKGVEFAEQGEYNIDGDLTFTENPDGSLSLNWSREHLGSGSVGKIKEGFITITPIKLDFTDYDTLNAMKNSYAEEFSSIVN
Atome Classification :
(23 SA)
.........10........20........30........40-.........50........60.--...---....70........80........90........100.......110.......120.......-130----.-......140.......150--.........160..--.--....170.......180.......190.......200----.....------...210------..----.......220.......230.......240.......250
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
I
I
L
I
TNDDGF
E
S
E
G
I
K
L
L
K
E
V
A
R
N
F
A
S
E
I
W
I
VAPDTDRS--GAARSLDH
P
V
K
Q
S
I
RINQHN
E
R
--
E
F
S---VSGTP
A
D
C
V
I
I
A
L
N
K
I
MDKKP
D
L
V
L
SGVNIGSNVGDDVCYSG
T
I
G
A
V
M
E
G
A
A
R
S
I
P
S
I
A
L
S
Q
A
Y-HGG----
I
-
N
WYN
T
K
IF
A
P
K
V
I
A
K
L
V
----KVGWPK
N
I
A
M
S
I
NF--S--ATEKVKG
V
E
FAEQGEYNIDG
D
L
T
F
TENPDG
S
L
S
L
N
W-----
S
R
E
HL------GSGS--------VG----KIKE
G
F
I
T
I
T
P
I
K
L
DFTDY
D
T
L
N
A
M
K
N
S
Y
A
E
E
F
S
S
IVN
23
PsiBlast_CBE
94.05
39%
-100
- C9 -
4ZG5
1
SURE_BRUA1
A:
[1-241]
M
R
I
L
L
T
N
D
D
G
I
H
A
E
G
L
A
V
L
E
R
I
A
R
K
L
S
D
D
V
W
V
V
A
P
E
T
D
Q
S
--
G
L
A
H
S
L
T
--
L
L
E
P
L
R
L
R
Q
I
D
A
R
--
H
F
A
---
L
R
G
T
P
T
D
C
V
I
M
G
V
R
H
V
L
P
G
A
P
D
L
V
L
S
G
V
N
S
G
A
N
M
A
D
D
V
T
Y
S
G
T
V
A
G
A
M
E
G
T
L
L
G
V
R
A
I
A
L
S
Q
E
Y
E
Y
--RRI-
V
-
P
W
E
T
A
E
A
H
A
P
E
L
I
G
R
L
M
----
E
A
G
W
P
E
G
V
L
L
N
L
N
F
P
N
C
--
A
P
E
E
V
K
G
V
R
V
T
A
Q
G
K
L
S
H
D
A
R
L
--
D
E
R
R
D
G
R
-
G
F
P
Y
-----
F
W
L
H
F
------
G
R
G
K
APVADDS
D
I
A
----
A
I
R
S
G
C
I
S
M
T
P
L
H
L
D
L
T
A
H
K
V
R
A
E
L
G
A
A
----------
1
PsiBlast_PDB
93.91
39%
-97
- C9 -
4ZG5
1
SURE_BRUA1
D:
[1-241]
M
R
I
L
L
T
N
D
D
G
I
H
A
E
G
L
A
V
L
E
R
I
A
R
K
L
S
D
D
V
W
V
V
A
P
E
T
D
Q
S
--
G
L
A
H
S
L
T
--
L
L
E
P
L
R
L
R
Q
I
D
A
R
--
H
F
A
---
L
R
G
T
P
T
D
C
V
I
M
G
V
R
H
V
L
P
G
A
P
D
L
V
L
S
G
V
N
S
G
A
N
M
A
D
D
V
T
Y
S
G
T
V
A
G
A
M
E
G
T
L
L
G
V
R
A
I
A
L
S
Q
E
Y
E
Y
A
G
DRRI
V
-
P
W
E
T
A
E
A
H
A
P
E
L
I
G
R
L
M
----
E
A
G
W
P
E
G
V
L
L
N
L
N
F
PN
C
--
A
P
E
E
V
K
G
V
R
V
T
A
Q
G
K
L
S
H
D
A
R
L
--
D
E
R
R
D
G
R
-
G
F
P
Y
-----
F
W
L
H
F
------
G
R
G
K
APVADDSD
I
A
----
A
I
R
S
G
C
I
S
M
T
P
L
H
L
D
L
T
A
H
K
V
R
A
E
L
G
A
A
L
G
--------
22
PsiBlast_CBE
93.85
39%
-97
- C9 -
4ZG5
1
SURE_BRUA1
C:
[1-241]
M
R
I
L
L
T
N
D
D
G
I
H
A
E
G
L
A
V
L
E
R
I
A
R
K
L
S
D
D
V
W
V
V
A
P
E
T
D
Q
S
--
G
L
A
H
S
L
T
--
L
L
E
P
L
R
L
R
Q
I
D
A
R
--
H
F
A
---
L
R
G
T
P
T
D
C
V
I
M
G
V
R
H
V
L
P
G
A
P
D
L
V
L
S
G
V
N
S
G
A
N
M
A
D
D
V
T
Y
S
G
T
V
A
G
A
M
E
G
T
L
L
G
V
R
A
I
A
L
S
Q
E
Y
E
Y
A
G
D
R
R
I
V
-
P
W
E
T
A
E
A
H
A
P
E
L
I
G
R
L
M
----
E
A
G
W
P
E
G
V
L
L
N
L
N
F
PN
C
--
A
P
E
E
V
K
G
V
R
V
T
A
Q
G
K
L
S
H
D
A
R
L
--
D
E
R
R
D
G
R
-
G
F
P
Y
-----
F
W
L
H
F
------
G
R
G
K
AP
V
A
D
D
S
D
I
A
----
A
I
R
S
G
C
I
S
M
T
P
L
H
L
D
L
T
A
H
K
V
R
A
E
L
G
A
-----------
21
PsiBlast_CBE
93.57
39%
-99
- C9 -
4ZG5
1
SURE_BRUA1
G:
[1-241]
M
R
I
L
L
T
N
D
D
G
I
H
A
E
G
L
A
V
L
E
R
I
A
R
K
L
S
D
D
V
W
V
V
A
P
E
T
D
Q
S
--
G
L
A
H
S
L
T
--
L
L
E
P
L
R
L
R
Q
I
D
A
R
--
H
F
A
---
L
R
G
T
P
T
D
C
V
I
M
G
V
R
H
V
L
P
G
A
P
D
L
V
L
S
G
V
N
S
G
A
N
M
A
D
D
V
T
Y
S
G
T
V
A
G
A
M
E
G
T
L
L
G
V
R
A
I
A
L
S
Q
E
Y
E---RI--
V
-
P
W
E
T
A
E
A
H
A
P
E
L
I
G
R
L
M
----
E
A
G
W
P
E
G
V
L
L
N
L
N
F
PN
C
--
A
P
E
E
V
K
G
V
R
V
T
A
Q
G
K
L
S
H
D
A
R
L
--
D
E
R
R
D
G
R
-
G
F
P
Y
-----
F
W
L
H
F
------
G
R
G
K
APVADDSD
I
A
----
A
I
R
S
G
C
I
S
M
T
P
L
H
L
D
L
T
A
H
K
V
R
A
E
L
G
A
A
L
G
--------
14
PsiBlast_PDB
86.80
32%
-77
- C9 -
1J9J
2
SURE_THEMA
A:
[1-246]
M
R
I
L
V
T
N
D
D
G
I
Q
S
K
G
I
I
V
L
A
E
L
L
S
E
-
E
H
E
V
F
V
V
A
P
D
K
E
R
S
--
A
T
G
H
S
I
T
I
H
V
P
L
W
M
K
K
V
F
I
S
E
R
V
V
A
Y
S
---
T
T
G
T
P
A
D
C
V
K
L
A
Y
N
V
V
M
D
K
R
V
D
L
I
V
S
G
V
N
R
G
P
N
M
G
M
D
I
L
H
S
G
T
V
S
G
A
M
E
G
A
M
M
N
I
P
S
I
A
I
S
S
A
N
-
Y
E
S
----
P
-
D
F
E
G
A
A
R
F
L
I
D
F
L
K
E
F
D
----
F
S
L
L
D
P
F
T
M
L
N
I
N
V
--
P
--
A
G
E
-
I
K
G
W
R
F
T
R
Q
S
R
R
R
W
N
D
Y
F
E
E
R
V
S
P
F
G
E
-
K
Y
Y
W
-----
M
M
G
E
V
I
E
DDDR
D
D
V
D
--------
Y
K
----
A
V
R
E
G
Y
V
S
I
T
P
I
H
P
F
L
T
N
E
Q
C
L
K
K
L
R
E
V
Y
D
--------
45
PsiBlast_CBE
86.77
32%
-77
- C9 -
1J9L
3
SURE_THEMA
B:
[1-246]
M
R
I
L
V
T
N
D
D
G
I
Q
S
K
G
I
I
V
L
A
E
L
L
S
E
-
E
H
E
V
F
V
V
A
P
D
K
E
R
S
--
A
T
G
H
S
I
T
I
H
V
P
L
W
M
K
K
V
F
I
S
E
R
VV
A
Y
S
---
T
T
G
T
P
A
D
C
V
K
L
A
Y
N
V
V
M
D
K
R
V
D
L
I
V
S
G
V
N
R
G
P
N
M
G
M
D
I
L
H
S
G
T
V
S
G
A
M
E
G
A
M
M
N
I
P
S
I
A
I
S
S
A
N
-
Y
E
S
----
P
-
D
F
E
G
A
A
R
F
L
I
D
F
L
K
E
F
D
----
F
S
L
L
D
P
F
T
M
L
N
I
N
V
--
P
--
A
G
E
-
I
K
G
W
R
F
T
R
Q
S
R
R
R
W
N
D
Y
F
E
E
R
V
S
P
F
G
E
-
K
Y
Y
W
-----
M
M
G
E
V
IEDDDR
D
D
V
D
--------
Y
K
----
A
V
R
E
G
Y
V
S
I
T
P
I
H
P
F
L
T
N
E
Q
C
L
K
K
L
R
E
V
Y
D
--------
46
PsiBlast_CBE
86.59
32%
-76
- C9 -
1J9K
3
SURE_THEMA
B:
[1-246]
M
R
I
L
V
T
N
D
D
G
I
Q
S
K
G
I
I
V
L
A
E
L
L
S
E
-
E
H
E
V
F
V
V
A
P
D
K
E
R
S
--
A
T
G
H
S
I
T
I
H
V
P
L
W
M
K
K
V
F
I
S
E
R
VV
A
Y
S
---
T
T
G
T
P
A
D
C
V
K
L
A
Y
N
V
V
M
D
K
R
V
D
L
I
V
S
G
V
N
R
G
P
N
M
G
M
D
I
L
H
S
G
T
V
S
G
A
M
E
G
A
M
M
N
I
P
S
I
A
I
S
S
A
N
-
Y
E
S
----
P
-
D
F
E
G
A
A
R
F
L
I
D
F
L
K
E
F
D
----
F
S
L
L
D
P
F
T
M
L
N
I
N
V
--
P
--
A
G
E
-
I
K
G
W
R
F
T
R
Q
S
R
R
R
W
N
D
Y
F
E
E
R
V
S
P
F
G
E
-
K
Y
Y
W
-----
M
M
G
E
V
IEDDDR
D
D
V
D
--------
Y
K
----
A
V
R
E
G
Y
V
S
I
T
P
I
H
P
F
L
T
N
E
Q
C
L
K
K
L
R
E
V
Y
D
--------
15
PsiBlast_PDB
86.55
32%
-78
- C9 -
1J9K
3
SURE_THEMA
A:
[1-246]
M
R
I
L
V
T
N
D
D
G
I
Q
S
K
G
I
I
V
L
A
E
L
L
S
E
-
E
H
E
V
F
V
V
A
P
D
K
E
R
S
--
A
T
G
H
S
I
T
I
H
V
P
L
W
M
K
K
V
F
I
S
E
R
V
V
A
Y
S
---
T
T
G
T
P
A
D
C
V
K
L
A
Y
N
V
V
M
D
K
R
V
D
L
I
V
S
G
V
N
R
G
P
N
M
G
M
D
I
L
H
S
G
T
V
S
G
A
M
E
G
A
M
M
N
I
P
S
I
A
I
S
S
A
N
-
Y
E
S
----
P
-
D
F
E
G
A
A
R
F
L
I
D
F
L
K
E
F
D
----
F
S
L
L
D
P
F
T
M
L
N
I
N
V
--
P
--
A
G
E
-
I
K
G
W
R
F
T
R
Q
S
R
R
R
W
N
D
Y
F
E
E
R
V
S
P
F
G
E
-
K
Y
Y
W
-----
M
M
G
E
V
I
EDDDR
D
D
V
D
--------
Y
K
----
A
V
R
E
G
Y
V
S
I
T
P
I
H
P
F
L
T
N
E
Q
C
L
K
K
L
R
E
V
Y
D
--------
16
PsiBlast_PDB
86.40
32%
-75
- C9 -
1J9L
3
SURE_THEMA
A:
[1-246]
M
R
I
L
V
T
N
D
D
G
I
Q
S
K
G
I
I
V
L
A
E
L
L
S
E
-
E
H
E
V
F
V
V
A
P
D
K
E
R
S
--
A
T
G
H
S
I
T
I
H
V
P
L
W
M
K
K
V
F
I
S
E
R
V
V
A
Y
S
---
T
T
G
T
P
A
D
C
V
K
L
A
Y
N
V
V
M
D
K
R
V
D
L
I
V
S
G
V
N
R
G
P
N
M
G
M
D
I
L
H
S
G
T
V
S
G
A
M
E
G
A
M
M
N
I
P
S
I
A
I
S
S
A
N
-
Y
E
S
----
P
-
D
F
E
G
A
A
R
F
L
I
D
F
L
K
E
F
D
----
F
S
L
L
D
P
F
T
M
L
N
I
N
V
--
P
--
A
G
E
-
I
K
G
W
R
F
T
R
Q
S
R
R
R
W
N
D
Y
F
E
E
R
V
S
P
F
G
E
-
K
Y
Y
W
-----
M
M
G
E
V
I
E
DDDR
D
D
V
D
--------
Y
K
----
A
V
R
E
G
Y
V
S
I
T
P
I
H
P
F
L
T
N
E
Q
C
L
K
K
L
R
E
V
Y
D
--------
20
PsiBlast_PDB
86.23
31%
-86
- C9 -
2E6B
8
SURE_THET8
A:
[1-238]
M
R
I
L
V
T
N
D
D
G
I
Y
S
P
G
L
W
A
L
A
E
A
A
S
Q
F
G
-
E
V
F
V
A
A
P
D
T
-----
G
H
A
I
T
I
A
H
P
V
R
A
Y
P
H
P
S
P
L
H
A
P
--
H
F
P
A
Y
R
V
R
G
T
P
A
D
C
V
A
L
G
L
H
--
L
F
G
P
V
D
L
V
L
S
G
V
N
L
G
S
N
L
G
H
E
I
W
H
S
G
T
V
A
A
A
K
Q
G
Y
L
F
G
L
S
A
A
A
F
S
V
P
L
-
N
G
E
----
V
P
D
F
A
G
L
R
P
W
L
L
R
T
L
E
T
L
L
----
R
L
E
R
P
----
F
L
V
N
V
--
N
--
L
P
L
R
P
K
G
F
L
W
T
R
Q
S
V
R
A
Y
E
G
V
V
I
P
G
E
D
P
M
G
R
P
F
Y
W
F
-----
A
P
R
P
L
------
K
E
A
E
--------
E
G
T
D
R
W
A
V
A
Q
G
F
V
S
A
T
P
L
R
L
D
L
T
D
E
T
R
L
Q
P
T
L
A
-----------
71
PsiBlast_CBE
85.97
31%
-83
- C9 -
2E6H
8
SURE_THET8
B:
[1-238]
M
R
I
L
V
T
N
D
D
G
I
Y
S
P
G
L
W
A
L
A
E
A
A
S
Q
F
-
G
E
V
F
V
A
A
P
D
-------
H
A
I
T
I
A
H
P
V
R
A
Y
P
H
P
S
P
---
P
--
H
F
P
A
Y
R
V
R
G
T
P
A
D
C
V
A
L
G
L
H
--
L
F
G
P
V
D
L
V
L
S
G
V
N
L
G
S
N
L
G
H
E
I
W
H
S
G
T
V
A
A
A
K
Q
G
Y
L
F
G
L
S
A
A
A
F
S
V
P
L
-
N
G
E
----
V
P
D
F
A
G
L
R
P
W
L
L
R
T
L
E
T
L
L
----
R
L
E
R
P
----
F
L
V
N
V
--
N
--
L
P
L
R
P
K
G
F
L
W
T
R
Q
S
V
R
A
Y
E
G
V
V
I
P
G
E
D
P
M
G
R
P
F
Y
W
F
-----
A
P
R
P
L
------
K
E
A
E
--------
E
G
T
D
R
W
A
V
A
Q
G
F
V
S
A
T
P
L
R
L
D
L
T
D
E
T
R
L
Q
P
T
L
------------
70
PsiBlast_CBE
85.86
31%
-83
- C9 -
2E6H
3
SURE_THET8
C:
[1-237]
M
R
I
L
V
T
N
D
D
G
I
Y
S
P
G
L
W
A
L
A
E
A
A
S
Q
F
-
G
E
V
F
V
A
A
P
D
------
G
H
A
I
T
I
A
H
P
V
R
A
Y
P
H
P
S
P
L
H
A
P
--
H
F
P
A
Y
R
V
R
G
T
P
A
D
C
V
A
L
G
L
H
--
L
F
G
P
V
D
L
V
L
S
G
V
N
L
G
S
N
L
G
H
E
I
W
H
S
G
T
V
A
A
A
K
Q
G
Y
L
F
G
L
S
A
A
A
F
S
V
P
L
-
N
G
E
----
V
P
D
F
A
G
L
R
P
W
L
L
R
T
L
E
T
L
L
----
R
L
E
R
P
----
F
L
V
N
V
--
N
--
L
P
L
R
P
K
G
F
L
W
T
R
Q
S
V
R
A
Y
E
G
V
V
I
P
G
E
D
P
M
G
R
P
F
Y
W
F
-----
A
P
R
P
L
------
K
E
A
E
--------
E
G
T
D
R
W
A
V
A
Q
G
F
V
S
A
T
P
L
R
L
D
L
T
D
E
T
R
L
----------------
18
PsiBlast_PDB
85.69
30%
-94
- C9 -
3TY2
1
SURE_COXBU
A:
[12-252]
L
R
L
L
L
S
N
D
D
G
V
Y
A
K
G
L
A
I
L
A
K
T
L
A
D
L
G
-
E
V
D
V
V
A
P
D
R
N
R
S
--
G
A
S
N
S
L
T
--
L
N
A
P
L
H
I
K
N
L
E
N
G
--
M
I
S
---
V
E
G
T
P
T
D
C
V
H
L
A
I
T
G
V
L
P
E
M
P
D
M
V
V
A
G
I
N
A
G
P
N
L
G
D
D
V
W
Y
S
G
T
V
A
A
A
-
E
G
R
F
L
G
L
P
A
L
A
V
S
L
----
G
G
EL--
F
-
R
Y
Y
E
T
---
A
A
K
V
V
Y
Q
L
I
Q
R
I
E
K
D
P
L
P
P
S
T
I
L
N
I
N
V
--
P
DL
P
Y
E
E
L
K
G
F
E
V
T
R
L
G
T
R
H
R
A
E
P
T
I
R
Q
I
D
P
R
G
H
-
P
I
Y
W
V
G
A
A
G
P
E
Q
D
S
------
G
P
G
T
D
-------
F
F
----
A
M
N
H
H
C
V
S
I
T
P
L
R
V
D
L
T
H
Y
E
A
F
D
Q
L
A
S
W
V
K
R
L
E
M
----
60
PsiBlast_CBE
85.64
31%
-83
- C9 -
2E6C
3
SURE_THET8
C:
[1-238]
M
R
I
L
V
T
N
D
D
G
I
Y
S
P
G
L
W
A
L
A
E
A
A
S
Q
F
G
-
E
V
F
V
A
A
P
D
T
E
Q
S
AA
G
H
A
I
T
I
A
H
P
V
R
A
Y
P
H
P
S
P
L
H
A
P
--
H
F
P
AYR
V
R
G
T
P
A
D
C
V
A
L
G
L
H
--
L
F
G
P
V
D
L
V
L
S
G
V
N
L
G
S
N
L
G
H
E
I
W
H
S
G
T
V
A
A
A
K
Q
G
Y
L
F
G
L
S
A
A
A
F
S
V
P
L
-
N
G
E
----
V
P
D
F
A
G
L
R
P
W
L
L
R
T
L
E
T
L
L
----
R
L
E
R
P
----
F
L
V
N
V
--
N
--
L
P
L
R
P
K
G
F
L
W
T
R
Q
S
V
R
A
Y
E
G
V
V
I
P
G
E
D
P
M
G
R
P
F
Y
W
F
-----
A
P
R
P
L
------
K
E
A
E
--------
E
G
TDRW
A
V
A
Q
G
F
V
S
A
T
P
L
R
L
D
L
T
D
E
T
R
L
Q
---------------
19
PsiBlast_PDB
85.55
31%
-84
- C9 -
2E69
7
SURE_THET8
A:
[1-238]
M
R
I
L
V
T
N
D
D
G
I
Y
S
P
G
L
W
A
L
A
E
A
A
S
Q
F
G
-
E
V
F
V
A
A
P
D
------
G
H
A
I
T
I
A
H
P
V
R
A
Y
P
H
P
S
P
L
H
A
P
--
H
F
P
A
Y
R
V
R
G
T
P
A
D
C
V
A
L
G
L
H
--
L
F
G
P
V
D
L
V
L
S
G
V
N
L
G
S
N
L
G
H
E
I
W
H
S
G
T
V
A
A
A
K
Q
G
Y
L
F
G
L
S
A
A
A
F
S
V
P
L
-
N
G
E
----
V
P
D
F
A
G
L
R
P
W
L
L
R
T
L
E
T
L
L
----
R
L
E
R
P
----
F
L
V
N
V
--
N
--
L
P
L
R
P
K
G
F
L
W
T
R
Q
S
V
R
A
Y
E
G
V
V
I
P
G
E
D
P
M
G
R
P
F
Y
W
F
-----
A
P
R
P
L
------
K
E
A
E
--------
E
G
T
D
R
W
A
V
A
Q
G
F
V
S
A
T
P
L
R
L
D
L
T
D
E
T
R
L
Q
P
T
L
A
H
----------
67
PsiBlast_CBE
85.50
31%
-81
- C9 -
2E69
2
SURE_THET8
C:
[1-238]
M
R
I
L
V
T
N
D
D
G
I
Y
S
P
G
L
W
A
L
A
E
A
A
S
Q
F
G
-
E
V
F
V
A
A
P
D
-------
H
A
I
T
I
A
H
P
V
R
A
Y
P
H
P
S
P
L
H
A
P
--
H
F
P
A
Y
R
V
R
G
T
P
A
D
C
V
A
L
G
L
H
--
L
F
G
P
V
D
L
V
L
S
G
V
N
L
G
S
N
L
G
H
E
I
W
H
S
G
T
V
A
A
A
K
Q
G
Y
L
F
G
L
S
A
A
A
F
S
V
P
L
-
N
G
E
----
V
P
D
F
A
G
L
R
P
W
L
L
R
T
L
E
T
L
L
----
R
L
E
R
P
----
F
L
V
N
V
--
N
--
L
P
L
R
P
K
G
F
L
W
T
R
Q
S
V
R
A
Y
E
G
V
V
I
P
G
E
D
P
M
G
R
P
F
Y
W
F
-----
A
P
R
P
L
------
K
E
A
E
--------
E
G
T
D
R
W
A
V
A
Q
G
F
V
S
A
T
P
L
R
L
D
L
T
D
E
T
R
L
Q
---------------
68
PsiBlast_CBE
85.48
31%
-86
- C9 -
2E69
5
SURE_THET8
B:
[1-238]
M
R
I
L
V
T
N
D
D
G
I
Y
S
P
G
L
W
A
L
A
E
A
A
S
Q
F
G
-
E
V
F
V
A
A
P
D
-------
H
A
I
T
I
A
H
P
V
R
A
Y
P
H
P
S
P
---
P
--
H
F
P
A
Y
R
V
R
G
T
P
A
D
C
V
A
L
G
L
H
--
L
F
G
P
V
D
L
V
L
S
G
V
N
L
G
S
N
L
G
H
E
I
W
H
S
G
T
V
A
A
A
K
Q
G
Y
L
F
G
L
S
A
A
A
F
S
V
P
L
-
N
G
E
----
V
P
D
F
A
G
L
R
P
W
L
L
R
T
L
E
T
L
L
----
R
L
E
R
P
----
F
L
V
N
V
--
N
--
L
P
L
R
P
K
G
F
L
W
T
R
Q
S
V
R
A
Y
E
G
V
V
I
P
G
E
D
P
M
G
R
P
F
Y
W
F
-----
A
P
R
P
L
------
K
E
A
E
--------
E
G
T
D
R
W
A
V
A
Q
G
F
V
S
A
T
P
L
R
L
D
L
T
D
E
T
R
L
Q
P
T
L
A
-----------
61
PsiBlast_CBE
85.48
31%
-85
- C9 -
2E6C
5
SURE_THET8
B:
[1-238]
M
R
I
L
V
T
N
D
D
G
I
Y
S
P
G
L
W
A
L
A
E
A
A
S
Q
F
G
-
E
V
F
V
A
A
P
D
T
------
H
A
I
T
I
A
H
P
V
R
A
Y
P
H
P
S
P
L
H
A
P
--
H
F
P
A
Y
R
V
R
G
T
P
A
D
C
V
A
L
G
L
H
--
L
F
G
P
V
D
L
V
L
S
G
V
N
L
G
S
N
L
G
H
E
I
W
H
S
G
T
V
A
A
A
K
Q
G
Y
L
F
G
L
S
A
A
A
F
S
V
P
L
-
N
G
E
----
V
P
D
F
A
G
L
R
P
W
L
L
R
T
L
E
T
L
L
----
R
L
E
R
P
----
F
L
V
N
V
--
N
--
L
P
L
R
P
K
G
F
L
W
T
R
Q
S
V
R
A
Y
E
G
V
V
I
P
G
E
D
P
M
G
R
P
F
Y
W
F
-----
A
P
R
P
L
------
K
E
A
E
--------
E
G
T
D
R
W
A
V
A
Q
G
F
V
S
A
T
P
L
R
L
D
L
T
D
E
T
R
L
Q
P
T
L
A
H
----------
47
PsiBlast_CBE
85.48
32%
-76
- C9 -
1J9J
2
SURE_THEMA
B:
[1-246]
M
R
I
L
V
T
N
D
D
G
I
Q
S
K
G
I
I
V
L
A
E
L
L
S
E
-
E
H
E
V
F
V
V
A
P
D
K
E
R
S
--
A
T
G
H
S
I
T
I
H
V
P
L
W
M
K
K
V
F
I
S
E
R
VV
A
Y
S
---
T
T
G
T
P
A
D
C
V
K
L
A
Y
N
V
V
M
D
K
R
V
D
L
I
V
S
G
V
N
R
G
P
N
M
G
M
D
I
L
H
S
G
T
V
S
G
A
M
E
G
A
M
M
N
I
P
S
I
A
I
S
S
A
N
-
Y
E
S
----
P
-
D
F
E
G
A
A
R
F
L
I
D
F
L
K
E
F
D
----
F
S
L
L
D
P
F
T
M
L
N
I
N
V
--
P
--
A
G
E
-
I
K
G
W
R
F
T
R
Q
S
R
R
R
W
N
D
Y
F
E
E
R
V
S
P
F
G
E
-
K
Y
Y
W
-----
M
M
G
E
V
IEDDDR
D
D
V
D
--------
Y
K
----
A
V
R
E
G
Y
V
S
I
T
P
I
H
P
F
L
T
N
E
Q
C
L
K
K
L
R
E
V
Y
D
--------
56
PsiBlast_CBE
85.38
31%
-88
- C9 -
2E6G
2
SURE_THET8
C:
[1-237]
M
R
I
L
V
T
N
D
D
G
I
Y
S
P
G
L
W
A
L
A
E
A
A
S
Q
F
G
-
E
V
F
V
A
A
P
D
---------
I
T
I
A
H
P
V
R
A
Y
P
H
P
S
P
---
P
--
H
F
P
A
Y
R
V
R
G
T
P
A
D
C
V
A
L
G
L
H
--
L
F
G
P
V
D
L
V
L
S
G
V
N
L
G
S
N
L
G
H
E
I
W
H
S
G
T
V
A
A
A
K
Q
G
Y
L
F
G
L
S
A
A
A
F
S
V
P
L
-
N
G
E
----
V
P
D
F
A
G
L
R
P
W
L
L
R
T
L
E
T
L
L
----
R
L
E
R
P
----
F
L
V
N
V
--
N
--
L
P
L
R
P
K
G
F
L
W
T
R
Q
S
V
R
A
Y
E
G
V
V
I
P
G
E
D
P
M
G
R
P
F
Y
W
F
-----
A
P
R
P
L
------
K
E
A
E
--------
E
G
TDRW
A
V
A
Q
G
F
V
S
A
T
P
L
R
L
D
L
T
D
E
T
R
L
----------------
65
PsiBlast_CBE
84.52
31%
-86
- C9 -
2E6B
6
SURE_THET8
B:
[1-238]
M
R
I
L
V
T
N
D
D
G
I
Y
S
P
G
L
W
A
L
A
E
A
A
S
Q
F
G
-
E
V
F
V
A
A
P
D
T
------
H
A
I
T
I
A
H
P
V
R
A
Y
P
H
P
S
P
L
--
P
--
H
F
P
A
Y
R
V
R
G
T
P
A
D
C
V
A
L
G
L
H
--
L
F
G
P
V
D
L
V
L
S
G
V
N
L
G
S
N
L
G
H
E
I
W
H
S
G
T
V
A
A
A
K
Q
G
Y
L
F
G
L
S
A
A
A
F
S
V
P
L
-
N
G
E
----
V
P
D
F
A
G
L
R
P
W
L
L
R
T
L
E
T
L
L
----
R
L
E
R
P
----
F
L
V
N
V
--
N
--
L
P
L
R
P
K
G
F
L
W
T
R
Q
S
V
R
A
Y
E
G
V
V
I
P
G
E
D
P
M
G
R
P
F
Y
W
F
-----
A
P
R
P
L
------
K
E
A
E
--------
E
G
T
D
R
W
A
V
A
Q
G
F
V
S
A
T
P
L
R
L
D
L
T
D
E
T
R
L
Q
P
T
L
------------
63
PsiBlast_CBE
84.48
31%
-87
- C9 -
2E6B
4
SURE_THET8
D:
[1-237]
M
R
I
L
V
T
N
D
D
G
I
Y
S
P
G
L
W
A
L
A
E
A
A
S
Q
F
G
-
E
V
F
V
A
A
P
D
T
------
H
A
I
T
I
A
H
P
V
R
A
Y
P
H
P
S
P
L
H
A
P
--
H
F
P
AYR
V
R
G
T
P
A
D
C
V
A
L
G
L
H
--
L
F
G
P
V
D
L
V
L
S
G
V
N
L
G
S
N
L
G
H
E
I
W
H
S
G
T
V
A
A
A
K
Q
G
Y
L
F
G
L
S
A
A
A
F
S
V
P
L
-
N
G
E
----
V
P
D
F
A
G
L
R
P
W
L
L
R
T
L
E
T
L
L
----
R
L
E
R
P
----
F
L
V
N
V
--
N
--
L
P
L
R
P
K
G
F
L
W
T
R
Q
S
V
R
A
Y
E
G
V
V
I
P
G
E
D
P
M
G
R
P
F
Y
W
F
-----
A
P
R
P
L
------
K
E
A
E
--------
E
G
TDRW
A
V
A
Q
G
F
V
S
A
T
P
L
R
L
D
L
T
D
E
T
R
L
----------------
64
PsiBlast_CBE
84.43
31%
-85
- C9 -
2E6B
3
SURE_THET8
C:
[1-238]
M
R
I
L
V
T
N
D
D
G
I
Y
S
P
G
L
W
A
L
A
E
A
A
S
Q
F
G
-
E
V
F
V
A
A
P
D
T
------
H
A
I
T
I
A
H
P
V
R
A
Y
P
H
P
S
P
L
H
A
P
--
H
F
P
A
Y
R
V
R
G
T
P
A
D
C
V
A
L
G
L
H
--
L
F
G
P
V
D
L
V
L
S
G
V
N
L
G
S
N
L
G
H
E
I
W
H
S
G
T
V
A
A
A
K
Q
G
Y
L
F
G
L
S
A
A
A
F
S
V
P
L
-
N
G
E
----
V
P
D
F
A
G
L
R
P
W
L
L
R
T
L
E
T
L
L
----
R
L
E
R
P
----
F
L
V
N
V
--
N
--
L
P
L
R
P
K
G
F
L
W
T
R
Q
S
V
R
A
Y
E
G
V
V
I
P
G
E
D
P
M
G
R
P
F
Y
W
F
-----
A
P
R
P
L
------
K
E
A
E
--------
E
G
T
D
R
W
A
V
A
Q
G
F
V
S
A
T
P
L
R
L
D
L
T
D
E
T
R
L
Q
---------------