@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0554: (2015-12-02 )
MSSNIPQNAVEVDTLSSIYTYKELSIDKLKHEYEITVGSNYIEQKVNSRLQEIAKNAKLPGFRSGKMPYDLVVTNYKNEALEYVVNSTIDYCSSDLMKKIEVKSHIYPKVDIMSLPNLNEEGEKSNFVYKLSFESMPEVPVIDLDKINLKKVEARIEEEDIKGFVDSIKTRFPSFVSVDDASYQAKNGDKLVIDFEGRIRNKLFQGGSNKNFKVTLGSGTFINGFENQLTGMKKGETKSFKLKFPEDYQTISLAGQEANFSVRVNDIQVAEDFGGDDEMAKKIGFRDCSSLKNHAKEVIGGQCEEMRDLLIKKELFDYLDANYSFDLPTDVVRQEQQRVERELGSKDDSCKEAERRVKLAMLFMKFSTEHKISLTQNDILNVIVNQYISKDVPFDRVFKHFKSDRQFQELVRGQALEHKVTSYIIEKVNKEEQIVSVKELKELFGNI
Atome Classification :
(20 SA)
-----------------------------------------------------------.........10.......-.20.....-...30.......-.40........50........60........70........80.....----------...90........100.......110.......--120--.......130.-------------......140....----...150-.......160-.......170.......180......-----.190.......-200-----......--.--210.......220.......230.......240.......----------------------------------------------------250----..------...-...260.....--..270.......280..--..----------.--.----.290.......300..----.-....310-.........320.......330...-----....340---...-------------.-------------....350------.--------........360-........370...---------------------------------------------....380.......-390.......400.......410..----.....420.......430--.........440.....--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------MSSNIPQNA
V
E
V
D
T
L
S
S
I
-
Y
T
Y
K
EL
S
I
-
D
K
L
K
H
E
Y
E
I
T
VG-
S
N
Y
I
E
Q
K
V
N
S
R
L
Q
E
I
A
K
NAKLPGFRSGKM
P
Y
D
L
V
V
TNYK
N
E
A
L
E
Y
V
V
N
----------
S
T
I
D
Y
C
S
S
D
L
M
K
K
I
E
V
KSHIYPKV
D
I
M
SLPNLN--EEG--EKS
N
F
V
Y
K
L
SF-------------ESMPEVP
V
I
DLDK----I
N
L
K
K
V
-
E
A
R
I
E
E
E
D
I
K
-
G
F
V
D
S
I
K
T
RFP
S
F
V
SVDDASYQAKNG-----
D
K
L
V
I
DFEG
R
I
-
R
N
K
-----
L
FQGGS--N--K
N
F
K
V
T
LGS
G
T
F
IN
G
F
E
N
Q
LTGMKKGETK
S
F
K
L
KFPEDY
Q
----------------------------------------------------
T
I
-----
S
L------AGQ-EA
N
F
S
V
R
V
N
D
I
--
Q
V
A
E
DFG
G
D
D
E
M
A
K
K
IG--F
R
----------
D
--
C
----
S
S
L
K
N
H
A
K
E
V
IGG
Q
C
E
----
E
-
M
R
D
L
L
---
I
K
K
E
L
F
D
Y
LDANYSFDL
P
T
D
V
V
R
Q
E
-----
Q
Q
R
V
E
R
----
E
LG-------------S-------------KDD
S
C
--------
K
--------
E
A
E
R
R
V
K
L
A
M
--
L
F
M
KFSTE
H
K
I
SL
T
---------------------------------------------
Q
N
D
I
L
N
V
I
V
N
Q
Y
IS-KDV
P
F
D
R
V
F
K
H
F
KS
D
R
Q
F
Q
E
L
V
R
G
Q
----
A
L
E
H
K
V
T
S
Y
I
I
E
KVN
K
----
E
E
Q
I
V
S
V
K
E
L
K
E
L
FGNI--
1
PsiBlast_PDB
82.48
25%
-52
- C6 -
1T11
-
TIG_VIBCH
A:
[7-378]
------------------------------------------------------------------------------------
T
L
-
E
G
L
Q
R
R
L
N
I
T
V
P
-
A
A
N
I
E
D
A
V
A
A
E
L
R
N
I
A
K
N
R
R
F
D
G
F
R
K
G
K
V
P
M
K
M
V
A
K
M
Y
G
K
A
V
R
Q
D
V
L
------------------
G
E
V
M
Q
R
H
F
I
E
A
I
V
K
E
K
I
N
P
A
G
A
P
T
F
A
P
V
E
I
G
--
E
G
K
D
L
V
F
T
A
T
F
-------------
E
V
Y
P
E
V
E
L
K
G
L
E
N
----
I
A
V
E
K
P
-
A
A
---
D
A
D
V
A
-
E
M
L
E
T
L
R
K
Q
Q
A
T
W
K
E
V
D
E
A
---
A
E
N
G
-----
K
R
V
S
I
D
F
V
G
S
I
-
D
G
V
-----
E
F
E
G
G
K
--
A
--
E
N
F
P
L
E
M
G
A
G
R
M
I
P
G
F
E
D
G
I
V
G
K
T
K
G
M
E
F
V
I
D
V
T
F
P
E
D
Y
H
----------------------------------------------------
A
E
-----
N
L
------
K
G
K
-
A
A
K
F
A
I
K
V
N
K
V
--
E
A
R
E
L
P
E
L
N
D
E
F
V
A
R
F
G
--
V
A
----------
E
GG
V
----
D
A
L
K
A
E
V
R
K
N
M
E
R
E
L
K
----
Q
-
A
I
K
A
R
---
I
K
E
Q
A
I
E
G
L
V
K
E
N
E
I
Q
V
P
S
A
L
I
D
Q
E
I
N
V
L
R
Q
Q
A
A
Q
R
----
F
G
G
-------------
N
-------------
V
E
A
A
A
--------
Q
LPRELF
E
E
Q
A
K
R
R
V
V
V
G
L
--
L
L
G
E
V
I
R
T
H
E
L
K
A
D
---------------------------------------------
E
E
K
V
K
A
L
I
T
E
M
A
T
A
-
Y
-------------------------------------------------------------------
54
HHSearch
69.92
17%
-50
- C8 -
3GTY
-
TIG_THEMA
X:
[1-414]
-------------------------------------------------------------------------------
M
E
V
K
E
L
E
R
D
K
N
R
V
V
L
E
Y
V
F
G
-
A
E
E
I
A
Q
A
E
D
K
A
V
R
Y
L
N
Q
R
V
E
I
P
G
--
K
G
R
I
P
K
N
V
L
K
M
K
L
G
E
E
F
Q
E
Y
T
L
D
-----------
F
L
M
D
L
I
P
D
T
L
K
D
-----
R
K
-----
L
I
L
S
P
I
V
T
--
E
R
E
L-
K
D
V
T
A
R
V
V
V
E
V
-------------
H
E
E
P
E
V
R
I
G
D
I
S
K
----
I
E
V
E
K
V
D
E
E
K
V
L
E
K
Y
V
E
-
R
R
I
E
D
L
R
E
S
H
A
L
L
E
P
K
---
E
G
P
A
E
A
G
-----
D
L
V
R
V
N
M
E
V
Y
N
E
E
G
K
-----
K
L
---
T
--
S
--
R
E
Y
E
Y
V
I
S
E
D
E
D
R
P
-
F
V
K
D
L
V
G
K
K
K
G
D
V
V
E
I
E
R
E
------------------------------------------------------------------
Y
------
E
G
K
-
K
Y
T
Y
K
L
E
V
E
E
V
--
Y
K
R
T
L
P
E
I
G
D
E
L
A
K
S
V
N
--
N
E
----------
F
--------
E
T
L
E
Q
L
K
E
S
L
K
K
E
G
K
EIYD
V
-
E
M
K
E
S
---
M
R
E
Q
L
L
E
K
L
P
E
I
V
E
I
E
I
S
D
R
T
L
E
I
L
-----
V
N
E
A
I
N
----
R
L
K
REGRYEQIVSSYE
S
EEKF---------
R
E
E
L
K
--------
E
--------
R
I
L
D
D
I
K
R
D
R
--
V
I
E
V
L
A
Q
E
K
G
I
S
V
N
---------------------------------------------
D
E
E
L
E
K
E
A
-
E
E
L
A
P
F
W
G
I
S
P
D
R
A
K
S
L
V
K
A
R
Q
D
L
R
E
E
L
R
W
A
----
I
L
K
R
K
V
L
D
L
L
L
Q
E
V
K
V
----
K
V
V
E
P
K
G
------------
3
PsiBlast_PDB
62.32
24%
174
- C- -
2VRH
-
TIG_ECOLI
A:
[11-427]
-----------------------------------------------------------------------------------------
L
G
R
R
V
T
I
T
I
A
-
A
D
S
I
E
T
A
V
K
S
E
L
V
N
V
A
K
K
V
R
I
D
G
F
R
K
G
K
V
P
M
N
I
V
A
Q
R
Y
G
A
S
V
R
Q
D
V
L
G
-------------
D
L
M
S
R
N
F
I
D
A
I
-
I
K
E
K
I
N
P
A
G
A
P
T
Y
V
P
G
E
Y
--
K
L
G
--
E
--
D
F
T
Y
S
V
E
F
-------------
E
V
Y
P
E
V
E
L
Q
G
L
E
A
----
I
E
V
E
K
P
-
I
V
E
V
T
D
A
D
V
D
-
G
M
L
D
T
L
R
K
Q
--------
Q
A
T
W
K
E
K
D
G
AVEA
E
D
R
V
T
I
D
F
T
G
S
V
-
D
G
E
-----
E
F
E
G
G
K
--
A
--
S
D
F
V
L
A
M
G
Q
G
R
M
I
P
G
F
E
D
G
I
K
G
H
K
A
G
E
E
F
T
I
D
V
T
F
P
E
E
Y
H
----------------------------------------------------
A
E
-----
N
L
------
K
G
K
-
A
A
K
F
A
I
N
L
K
K
V
--
E
E
R
E
L
P
E
L
T
A
E
F
I
K
R
F
G
--
V
E
----------
D
-------
G
S
V
E
G
L
R
A
E
V
R
K
N
M
E
R
----
E
-
L
K
S
A
I
R
N
R
V
K
S
Q
A
I
E
G
L
V
K
A
N
D
I
D
V
P
A
A
L
I
D
S
E
I
D
V
L
R
R
Q
A
A
Q
R
----
F
G
G
-------------
N
-------------
E
K
Q
A
L
ELPRELF
E
E
--------
Q
A
K
R
R
V
V
V
G
L
--
L
L
G
E
V
I
R
T
N
E
L
K
A
D
---------------------------------------------
E
E
R
V
K
G
L
I
E
E
M
A
S
A
-
Y
E
D
P
K
E
-
V
I
E
F
Y
S
K
N
K
E
L
M
D
N
M
R
N
V
----
A
L
E
E
Q
A
V
E
A
V
L
A
K
A
K
V
----
T
E
K
E
T
T
F
N
E
L
M
N
Q
Q
-----
2
PsiBlast_PDB
61.98
24%
30
- C6 -
1W26
-
TIG_ECOLI
A:
[11-427]
-----------------------------------------------------------------------------------------
L
G
R
R
V
T
I
T
I
A
-
A
D
S
I
E
T
A
V
K
S
E
L
V
N
V
A
K
K
V
R
I
D
G
F
R
K
G
K
V
P
M
N
I
V
A
Q
R
Y
G
A
S
V
R
Q
D
V
L
G
-------------
D
L
M
S
R
N
F
I
D
A
I
-
I
K
E
K
I
N
P
A
G
A
P
T
Y
V
P
G
E
Y
--
K
L
G
--
E
--
D
F
T
Y
S
V
E
F
-------------
E
V
Y
P
E
V
E
L
Q
G
L
E
A
----
I
E
V
E
K
P
-
I
V
E
V
T
D
A
D
V
D
-
G
M
L
D
T
L
R
K
Q
--------
Q
A
T
W
K
E
K
D
G
AVEA
E
D
R
V
T
I
D
F
T
G
S
V
-
D
G
E
-----
E
F
E
G
G
K
--
A
--
S
D
F
V
L
A
M
G
Q
G
R
M
I
P
G
F
E
D
G
I
K
G
H
K
A
G
E
E
F
T
I
D
V
T
F
P
E
E
Y
H
----------------------------------------------------
A
E
-----
N
L
------
K
G
K
-
A
A
K
F
A
I
N
L
K
K
V
--
E
E
R
E
L
P
E
L
T
A
E
F
I
K
R
F
G
--
V
E
----------
D
-------
G
S
V
E
G
L
R
A
E
V
R
K
N
M
E
R
----
E
-
L
K
S
A
I
R
N
R
V
K
S
Q
A
I
E
G
L
V
K
A
N
D
I
D
V
P
A
A
L
I
D
S
E
I
D
V
L
R
R
Q
A
A
Q
R
----
F
G
G
-------------
N
-------------
E
K
Q
A
L
ELPRELF
E
E
--------
Q
A
K
R
R
V
V
V
G
L
--
L
L
G
E
V
I
R
T
N
E
L
K
A
D
---------------------------------------------
E
E
R
V
K
G
L
I
E
E
M
A
S
A
-
Y
E
D
P
K
E
-
V
I
E
F
Y
S
K
N
K
E
L
M
D
N
M
R
N
V
----
A
L
E
E
Q
A
V
E
A
V
L
A
K
A
K
V
----
T
E
K
E
T
T
F
N
E
L
M
N
Q
Q
A
----
6
PsiBlast_PDB
54.75
31%
-67
- C7 -
1OMS
7
TIG_ECOLI
A:
[14-118]
-----------------------------------------------------------------------------------------
L
G
R
R
V
T
I
T
I
A
-
A
D
S
I
E
T
A
V
K
S
E
L
V
N
V
A
K
K
V
R
I
D
G
F
R
K
G
K
V
P
M
N
I
V
A
Q
R
Y
G
A
S
V
R
Q
D
V
L
G
-------------
D
L
M
S
R
N
F
I
D
A
I
-
I
K
E
K
I
N
P
A
G
A
P
T
Y
V
P
G
E
Y
--
K
L
G
--
E
--
D
F
T
Y
S
V
E
F
-------------
E
V
Y
P
E
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
53.47
24%
56
- C6 -
1T11
-
TIG_VIBCH
A:
[0-378]
------------------------------------------------------------------------------
H
M
Q
V
T
V
E
T
L
E
G
L
Q
R
R
L
N
I
T
V
P
-
A
A
N
I
E
D
A
V
A
A
E
L
R
N
I
A
K
N
R
R
F
D
G
F
R
K
G
K
V
P
M
K
M
V
A
K
M
Y
G
K
A
V
R
Q
D
V
L
G
----------
E
V
M
Q
R
H
F
I
E
A
I
V
K
-----
E
K
---
I
N
P
A
G
A
P
T
F
A
--
P
V
E
IG
E
G
K
D
L
V
F
T
A
T
F
-------------
E
V
Y
P
E
V
E
L
K
G
L
E
N
----
I
A
V
E
K
P
-
A
A
---
D
A
D
V
A
-
E
M
L
E
T
L
R
K
Q
Q
A
T
W
K
E
V
---
D
E
A
A
E
N
G
-----
K
R
V
S
I
D
F
V
G
S
I
-
D
G
V
-----
E
F
E
G
G
K
--
A
--
E
N
F
P
L
E
M
G
A
G
R
M
I
P
G
F
E
D
G
I
V
G
K
T
K
G
M
E
F
V
I
D
V
T
F
P
E
D
Y
H
----------------------------------------------------
A
E
-----
N
L
------
K
G
K
-
A
A
K
F
A
I
K
V
N
K
V
--
E
A
R
E
L
P
E
L
N
D
E
F
V
A
R
F
G
--
V
A
----------
E
--------
G
G
V
D
A
L
K
A
E
V
R
K
N
M
E
R
E
L
K
Q
-
A
I
K
A
R
---
I
K
E
Q
A
I
E
G
L
V
K
E
N
E
I
Q
V
P
S
A
L
I
D
Q
E
-----
I
N
V
L
R
Q
----
Q
A
A
-------------
Q
R
FGGN
V
E
A
A
A
Q
LP
R
E
L
F
E
--------
E
--------
Q
A
K
R
R
V
V
V
G
L
--
L
L
G
E
V
I
R
T
H
E
L
K
A
D
---------------------------------------------
E
E
K
V
K
A
L
I
-
T
E
M
A
T
A
Y
-------------------------------------------------------------------
52
HHSearch
53.45
22%
55
- C6 -
1W26
-
TIG_ECOLI
A:
[1-431]
-------------------------------------------------------------------------------
M
Q
V
S
V
E
T
T
Q
G
L
G
R
R
V
T
I
T
I
A
-
A
D
S
I
E
T
A
V
K
S
E
L
V
N
V
A
K
K
V
R
I
D
G
F
R
K
G
K
V
P
M
N
I
V
A
Q
R
Y
G
A
S
V
R
Q
D
V
L
G
----------
D
L
M
S
R
N
F
I
D
A
I
I
K
-----
E
K
---
I
N
P
A
G
A
P
T
Y
V
--
P
G
E
YK
L
G
E
D
F
T
Y
S
V
E
F
-------------
E
V
Y
P
E
V
E
L
Q
G
L
E
A
----
I
E
V
E
K
P
-
I
V
E
V
T
D
A
D
V
D
-
G
M
L
D
T
L
R
K
Q
Q
A
T
W
K
E
K
---
D
G
A
V
E
A
E
-----
D
R
V
T
I
D
F
T
G
S
V
-
D
G
E
-----
E
F
E
G
G
K
--
A
--
S
D
F
V
L
A
M
G
Q
G
R
M
I
P
G
F
E
D
G
I
K
G
H
K
A
G
E
E
F
T
I
D
V
T
F
P
E
E
Y
H
----------------------------------------------------
A
E
-----
N
L
------
K
G
K
-
A
A
K
F
A
I
N
L
K
K
V
--
E
E
R
E
L
P
E
L
T
A
E
F
I
K
R
F
G
--
V
E
----------
D
--------
G
S
V
E
G
L
R
A
E
V
R
K
N
M
E
R
E
L
K
S
-
A
I
R
N
R
---
V
K
S
Q
A
I
E
G
L
V
K
A
N
D
I
D
V
P
A
A
L
I
D
S
E
-----
I
D
V
L
R
R
----
Q
A
A
-------------
Q
R
FGGNEKQALELP
R
E
L
F
E
--------
E
--------
Q
A
K
R
R
V
V
V
G
L
--
L
L
G
E
V
I
R
T
N
E
L
K
A
D
---------------------------------------------
E
E
R
V
K
G
L
I
-
E
E
M
A
S
A
Y
E
D
-
P
K
E
V
I
E
F
Y
S
K
N
K
E
L
M
D
N
M
R
N
V
----
A
L
E
E
Q
A
V
E
A
V
L
A
K
A
K
V
----
T
E
K
E
T
T
F
N
E
L
M
N
Q
Q
A
----
7
PsiBlast_PDB
50.69
30%
-51
- C7 -
1P9Y
1
TIG_ECOLI
A:
[14-118]
-----------------------------------------------------------------------------------------
L
G
R
R
V
T
I
T
I
A
-
A
D
S
I
E
T
A
V
K
S
E
L
V
N
V
A
K
K
V
R
I
D
G
L
R
K
G
K
V
P
M
N
I
V
A
Q
R
Y
G
A
S
V
R
Q
D
V
L
G
-------------
D
L
M
S
R
N
F
I
D
A
I
-
I
K
E
K
I
N
P
A
G
A
P
T
Y
V
P
G
E
Y
--
K
L
G
--
E
--
D
F
T
Y
S
V
E
F
-------------
E
V
Y
P
E
V
E
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
HHSearch
50.60
20%
9
- C6 -
2K8I
-
SLYD_ECOLI
A:
[3-157]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
K
D
-----
L
V
V
S
L
A
Y
Q
V
R
T
E
D
G
V
-----
L
V
D
E
S
P
V-
S
--
A
P
L
D
Y
L
H
G
H
G
S
L
I
S
G
L
E
T
A
L
E
G
H
E
V
G
D
K
F
D
V
A
V
G
A
N
D
A
Y
G
QYDENL
V
Q
R
V
P
KDVFMGVDELQVG
M
R
F
L
A
E
T
DQGPVPVEITAVEDD
H
V
V
V
D
G
N
H
-----
M
L
------
A
G
Q
-
N
L
K
F
N
V
E
V
V
A
I
--
R
E
A
T
E
E
E
L
A
H
G
H
V
H
G
A
H
--
D
H
----------
H
--
H
----
D
H
D
H
D
H
H
H
H
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
HHSearch
50.57
13%
-50
* C8 *
2NSA
3
A:
[4-165]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
L
E
Q
L
K
E
S
L
K
K
E
G
K
EIYD
V
-
E
M
K
E
S
---
M
R
E
Q
L
L
E
K
L
P
E
I
V
E
I
E
I
S
D
R
T
L
E
I
L
-----
V
N
E
A
I
N
----
R
L
K
R
E
GR
Y
E
Q
I
V
S
S
Y
-
E
S
E
E
K
F
--------
R
E
E
L
K
--------
E
--------
R
I
L
D
D
I
K
R
D
R
--
V
I
E
V
L
A
Q
E
K
G
I
S
V
N
---------------------------------------------
D
E
E
L
E
K
E
A
-
E
E
L
A
P
F
W
G
I
S
P
D
R
A
K
S
L
V
K
A
R
Q
D
L
R
E
E
L
R
W
A
----
I
L
K
R
K
V
L
D
L
L
L
Q
E
V
E
H
----
H
H
H
----------------
9
PsiBlast_PDB
50.48
21%
-23
- C7 -
3GU0
-
TIG_THEMA
A:
[4-278]
---------------------------------------------------------------------------------
K
E
L
E
R
-
D
K
N
R
V
V
L
E
Y
V
F
G
-
A
E
E
I
A
Q
A
E
D
K
A
V
R
Y
L
N
Q
R
V
E
I
P
G
F
R
K
G
R
I
P
K
N
V
L
K
M
K
L
G
E
E
F
Q
E
Y
T
L
D
----------
F
L
M
D
L
I
P
D
T
L
K
D
R
K
L
I
L
S
P
I
V
T
E
R
E
L
K
D
V
T
A
R
V
--
V
V
E
--
V
H
E
E
P
E
V
R
I
G
D
-------------
I
S
K
I
E
V
E
K
V
D
E
E
K
----
V
L
E
K
Y
V
-
E
R
R
I
--
E
D
L
R
-----------
E
S
H
A
L
L
E
P
K
E
G
P
A
E
A
G
-----
D
L
V
R
V
N
M
E
--
V
-
Y
N
E
-----
E
G
K
K
L
T
--
S
--
R
E
Y
E
Y
V
I
S
E
D
E
D
-
R
P
F
V
K
D
L
V
G
K
K
K
G
D
V
V
E
I
E
R
E
Y
------------------------------------------------------------------------
E
G
K
-
K
Y
T
Y
K
L
E
V
E
E
V
Y
K
R
T
L
P
E
I
G
--
D
E
L
A
K
S
V
N
NE
F
E
----------
T
--
L
EQLK
E
S
L
K
K
E
G
K
E
I
Y
D
V
E
M
K
----
E
S
M
R
E
Q
L
---
L
E
K
L
P
E
I
V
E
I
E
I
S
D
R
T
L
E
I
L
V
N
E
A
I
-----
N
R
L
K
R
E
----
G
R
Y
-------------
E
-------------
Q
I
V
S
S
--------
Y
--------
E
S
E
E
K
F
R
E
E
L
--
K
E
R
I
L
D
D
I
K
R
D
R
V
I
---------------------------------------------
E
V
L
A
Q
E
K
G
I
S
V
N
D
E
-
E
L
E
K
E
A
E
E
L
A
P
F
W
G
I
S
P
D
R
A
K
S
L
V
K
----
A
R
Q
D
L
R
E
E
L
R
W
A
I
L
K
R
----
K
V
L
D
L
L
L
Q
E
V
E
--------
5
PsiBlast_PDB
50.25
32%
5
- C6 -
1L1P
-
A:
[6-101]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
W
K
E
K
D
G
AVEA
E
D
R
V
T
I
D
F
T
G
S
V
-
D
G
E
-----
E
F
E
G
G
K
--
A
--
S
D
F
V
L
A
M
G
Q
G
R
M
I
P
G
F
E
D
G
I
K
G
H
K
A
G
E
E
F
T
I
D
V
T
F
P
E
E
Y
H
----------------------------------------------------
A
E
-----
N
L
------
K
G
K
-
A
A
K
F
A
I
N
L
K
K
V
--
E
E
R
E
L
P
E
L
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
HHSearch
48.84
14%
11
- C6 -
2D9F
-
FKBP8_HUMAN
A:
[32-131]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
P
V
K
G
-----
Q
V
V
T
V
H
L
Q
T
S
L
E
N
G
T
-----
R
V
Q
E
----
E
--
P
E
L
V
F
T
L
G
D
C
D
V
I
Q
A
L
D
L
S
V
P
L
M
D
V
G
E
T
A
M
V
T
A
D
S
K
Y
C
Y
G
----------------------------------------------------
P
Q
-----
G
S
R
SP
Y
I
P
P
H
A
-
A
L
C
L
E
V
T
L
K
T
A
--
V
D
R
P
D
L
E
M
S
G
P
S
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
HHSearch
48.71
24%
-4
- C6 -
2PBC
1
FKBP2_HUMAN
A:
[4-100]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
S
R
K
G
-----
D
V
L
H
M
H
Y
T
G
K
L
E
D
G
T
-----
E
F
D
S
S
L
--
P
QN
Q
P
F
V
F
S
L
G
T
G
Q
V
I
K
G
W
D
Q
G
L
L
G
M
C
E
G
E
K
R
K
L
V
I
P
S
E
L
G
Y
G
----------------------------------------------------
E
R
GAPPK
I
P
------
G
G
A
-
T
L
V
F
E
V
E
L
L
K
I
--
E
R
R
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
HHSearch
48.70
19%
0
* C6 *
1R9H
-
?
A:
[29-122]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
T
T
G
-----
T
T
V
K
V
H
Y
V
G
T
L
E
N
G
T
-----
K
F
D
S
S
R
DR
G
--
D
Q
F
S
F
N
L
G
R
G
N
V
I
K
G
W
D
L
G
V
A
T
M
T
K
G
E
V
A
E
F
T
I
R
S
D
Y
G
Y
G
----------------------------------------------------
D
A
-----
G
S
PPKIP-
G
G
A
-
T
L
I
F
E
V
E
L
F
E
W
--
S
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
Fugue
47.34
17%
-8
- C1 -
4XDN
5
SCC4_YEAST
A:
[24-640]
G
D
K
L
S
I
S
Q
V
Y
H
L
A
Q
E
Y
R
D
H
A
Y
S
I
A
NKIGS
E
E
G
L
K
Q
Y
Y
G
L
M
N
M
S
I
Q
M
F
Q
L
L
K
T
KCTLS
V
L
E
D
S
K
V
T
F
E
M
V
E
L
L
I
Q
E
T
Y
N
F
D
L
A
E
L
Y
I
-
S
S
L
K
E
R
L
Q
T
H
Q
S
D
T
D
L
V
E
E
I
M
R
C
E
F
L
L
L
H
---
D
L
P
L
M
R
D
S
K
F
H
Y
K
I
A
L
R
N
C
-
N
E
L
V
Q
Y
M
V
N
LQD
E
L
Y
Q
N
W
A
S
V
F
Q
Y
V
G
V
M
L
C
I
K
L
--
K
Q
H
R
R
V
K
T
S
F
H
G
L
L
S
Q
C
--
R
E
K
--
S
Q
W
K
W
F
L
N
L
C
Y
V
N
Y
L
L
N
E
RFPIP
E
D
A
L
Q
E
L
R
S
T
E
L
H
T
VG
P
E
L
Y
A
W
K
L
-
A
L
E
M
V
I
Q
L
C
K
D
G
N
I
T
D
H
L
N
E
F
K
N
F
F
D
T
N
K
Q
S
L
V
T
N
E
G
-----
K
G
C
V
I
K
I
M
P
R
I
-
A
L
K
V
E
L
PM
I
F
H
Y
K
E
--
L
--
K
N
I
L
L
L
L
Q
S
V
S
Y
I
V
N
C
Y
D
E
K
G
N
F
S
R
K
F
L
P
K
V
Y
S
T
T
Q
K
L
I
K
----------------------------------------------------
N
I
-----
A
A
------
G
G
V
S
M
N
E
L
D
S
R
I
Q
T
Y
--
K
S
I
L
E
F
C
E
F
Y
K
V
W
E
Q
T
L
--
L
K
GAVVLGPSPG
Y
--
V
----
R
L
L
Q
A
M
K
V
Q
F
E
G
G
G
A
V
----
E
-
E
Y
T
R
L
---
A
Q
S
---
G
G
T
S
S
E
V
K
M
I
S
L
L
N
C
Y
T
V
Q
-----
A
A
R
V
S
R
CSGD
K
Q
G
-------------
E
-------------
L
V
E
Q
C
--------
N
--------
K
V
W
L
Q
V
E
K
L
L
Q
E
T
D
L
Q
F
N
P
I
W
E
C
T
V
T
I
L
W
L
F
S
H
F
EPFSWNPLPCS
D
K
Q
R
A
E
Y
V
S
K
L
R
E
F
Y
S
S
N
KFVNRFKL
K
K
A
L
L
L
Q
I
L
V
N
Y
L
G
-
G
R
M
L
E
H
D
L
G
E
I
Y
A
I
S
A
K
C
F
D
M
C
R
Q
Q
GGM
R
K
V
Q
Y
V
I
G
I
W
H
L
M
N
C
T
V
A
MR
G
K
D
V
A
L
T
N
A
K
L
E
A
L
V
K
Q
I
T
S
76
Fugue
46.65
37%
-5
- C6 -
1HXV
-
A:
[29-113]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
A
N
G
-----
D
I
A
I
I
D
F
T
G
I
V
-
D
N
K
-----
K
L
A
S
A
S
--
A
--
Q
N
Y
E
L
T
I
G
S
N
S
F
I
K
G
F
E
T
G
L
I
A
M
K
V
N
Q
K
K
T
L
A
L
T
F
P
S
D
Y
H
----------------------------------------------------
V
K
-----
E
L
------
Q
S
K
-
P
V
T
F
E
V
V
L
K
A
I
--
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
46.65
37%
-5
- C6 -
1HXV
-
A:
[29-113]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
A
N
G
-----
D
I
A
I
I
D
F
T
G
I
V
-
D
N
K
-----
K
L
A
S
A
S
--
A
--
Q
N
Y
E
L
T
I
G
S
N
S
F
I
K
G
F
E
T
G
L
I
A
M
K
V
N
Q
K
K
T
L
A
L
T
F
P
S
D
Y
H
----------------------------------------------------
V
K
-----
E
L
------
Q
S
K
-
P
V
T
F
E
V
V
L
K
A
I
--
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
Fugue
46.18
24%
-43
- C7 -
1P9Y
1
TIG_ECOLI
A:
[4-120]
------------------------------------------------------------------------------
M
Q
V
S
V
E
T
T
-
Q
G
L
G
R
R
V
T
I
T
I
A
-
A
D
S
I
E
T
A
V
K
S
E
L
V
N
V
A
K
K
V
R
I
D
G
L
R
K
G
K
V
P
M
N
I
V
A
Q
R
Y
G
A
S
V
R
Q
D
V
L
G
----------
D
L
M
S
R
N
F
I
D
A
I
I
K
E
K
I
N
P
A
G
A
P
T
Y
V
P
------
G
--
E
Y
K
--
L
G
E
D
F
T
Y
S
V
E
F
-------------
E
V
Y
P
E
V
E
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
HHSearch
46.06
34%
-5
- C6 -
1HXV
-
A:
[29-113]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
A
N
G
-----
D
I
A
I
I
D
F
T
G
I
V
-
D
N
K
-----
K
L
A
S
A
S
--
A
--
Q
N
Y
E
L
T
I
G
S
N
S
F
I
K
G
F
E
T
G
L
I
A
M
K
V
N
Q
K
K
T
L
A
L
T
F
P
S
D
Y
H
----------------------------------------------------
V
K
-----
E
L
------
Q
S
K
-
P
V
T
F
E
V
V
L
K
A
I
--
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------