@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0561: (2015-12-02 )
MNNYDLIVIGGGPSGYKCAIAAAKLGLKVACIDKNSIFGGTCLRVGCIPSKALLHSSYQYVYTKNNLPKLGIKTKDVNFNLKEMLGYKDARVQELGKGIDYLFNLYKITKINGLGKITSFDQDSLKVSVEDKVLKTKNIVIATGSNVSSLPGINIDEKNIISSTGALSLTEVPKKLVVIGAGAIGLEISSVWSRLGSEVIVVEFLDRIAATMDGELSKSLLSSLQKQGIKFMLSTKVEKIKQNSNSLSVKVSSIKDNQTNTIETDKVLIAVGRKPCTEDLGIDEKIEEDNRGFIQVNNRYETNVKGIFAIGDVIGGAMLAHKAEEEGVAVAEIIAGQSPHVDYEIIPSVIYTHPAVSSIGKIEEELKSAGRKYKVGKCQFAANGRAKITDDAEGFVKVLTCSTTDTILGVHIIGAYADTLINEAAVAMAYGAAAEDIYRICHSHPDINEAFRDACIDAFFKK
Atome Classification :
(47 SA)
.........10........20........30...------.------....40........50......-..60---....--.....70...-.-.-...80........90......--..100.......110...------....120-...-....-------------130-.---........140.......150..--.--..---..160.......170-........180.......190.......200.......210-........220....-...230......-.240..--.-.-...250-.........260.......270.......280...-.-....290.......300.......310...-.-...320.......330.......--340-........350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNNY
D
L
I
V
IGGGPSG
Y
K
C
A
I
A
A
A
KLG
L
K
V
A
C
I
DK------N------SIFGG
T
C
L
R
VGCI
P
S
K
A
L
LHSS-
Y
Q
Y
----
V
Y
TK--NNLPKLG
I
K
T-K-D-VNF
N
L
K
E
MLGY
K
D
A
R
V
Q
E
L
G
K
--
G
I
D
Y
L
F
N
L
Y
K
I
T
KINGLG------KITSFDQ-D
S
L
-
K
V
S
V-------------E---
D
---
K
V
L
KTK
N
I
V
I
ATGSNVSSLPGIN--I--D
E
---
K
N
IISSTGAL
S
L
T
-E-VP
K
K
L
V
V
I
GA
G
A
IGL
E
I
S
S
V
W
S
R
LGSE
V
I
V
V
E
F
L
D
R
I
A
A
-T-MD
G
E
L
S
K
S
L
L
S
S
L
Q
K
-Q
G
I
K
F
M
L
S
T
K
V
E
-
K
I
KQNS--N-
S
-
L
S
V
K
---
V
S
SIKDNQTNTIET
D
K
V
L
I
A
VGRKPCTEDL-GIDE-K-IEEDNR
G
F
I
Q
VNNRYETNV
K
G
I
F
A
I
G
D
VI
G
-
G
-
A
M
L
AHKAEEEG
V
A
V
A
E
I
IAGQSP--HV--
D
Y
E
I
I
P
S
V
I
YTH
P
A
V
S
S
I
G
K
I
E
E
E
L
K
SAGRKYK
V
G
K
C
Q
F
AANGRAKITDDAE
G
F
V
K
V
L
T
CSTT
D
T
I
L
G
V
H
I
I
G
A
Y
A
D
T
L
I
N
E
A
A
V
A
M
AYG
A
A
A
E
D
I
Y
R
I
CHSHP
D
I
N
E
A
F
R
D
A
C
I
D
A
F
FKK
103
HHSearch
94.93
50%
-109
- C3 -
3URH
3
?
A:
[26-486]
---
Y
D
L
I
V
I
G
S
G
P
G
G
Y
V
C
A
I
K
A
A
Q
L
G
M
K
V
A
V
V
E
K
------
R
------
S
T
Y
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
S
-
E
M
F
----
H
Q
A
Q
--
H
G
L
E
A
L
G
V
E
V
-
A
-
N
-
P
K
L
N
L
Q
K
M
M
A
H
K
D
A
T
V
K
S
N
V
D
--
G
V
S
F
L
F
K
K
N
K
I
D
G
F
Q
G
T
G
------
K
V
L
G
--
Q
-
G
K
V
-
S
V
T
N
-------------
E
KG
E
E
---
Q
V
L
E
A
K
N
V
V
I
A
T
G
S
D
V
A
G
I
P
G
V
E
V
A
F
--
D
E
---
K
T
I
V
S
S
T
G
A
L
A
L
E
-
K
-
V
P
A
S
M
I
V
V
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
K
V
T
V
V
E
F
L
D
T
I
L
G
-
G
-
M
D
G
E
V
A
K
Q
L
Q
R
M
L
T
K
-
Q
G
I
D
F
K
L
G
A
K
V
T
-
G
A
V
K
S
G
--
D
-
G
-
A
K
V
T
---
F
E
P
V
K
G
G
E
A
T
T
L
D
A
E
V
V
L
I
A
T
G
R
K
P
S
T
D
G
L
-
G
L
A
K
-
A
G
V
V
L
D
S
R
G
R
V
E
I
D
R
H
F
Q
T
S
I
A
G
V
Y
A
I
G
D
V
V
R
-
G
-
P
M
L
A
H
K
A
E
D
E
G
V
A
V
A
E
I
I
A
G
Q
A
G
--
H
V
--
N
Y
D
V
I
P
G
V
V
Y
T
Q
P
E
V
A
S
V
G
K
T
E
E
E
L
K
A
A
G
V
A
Y
K
I
G
K
F
P
F
T
A
N
G
R
A
R
A
M
L
Q
T
D
G
F
V
K
I
L
A
D
K
E
T
D
R
V
L
G
G
H
I
I
G
F
G
A
G
E
M
I
H
E
I
A
V
L
M
E
F
G
G
S
S
E
D
L
G
R
T
C
H
A
H
P
T
M
S
E
A
V
K
E
A
A
L
S
T
F
F
--
7
PsiBlast_PDB
94.57
48%
-112
- C3 -
3URH
3
?
A:
[26-486]
---
Y
D
L
I
V
I
G
S
G
P
G
G
Y
V
C
A
I
K
A
A
Q
L
G
M
K
V
A
V
V
E
K
------
R
------
S
T
Y
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
S
-
E
M
F
----
H
Q
A
Q
--
H
G
L
E
A
L
G
V
E
V
-
A
-
N
-
P
K
L
N
L
Q
K
M
M
A
H
K
D
A
T
V
K
S
N
V
D
--
G
V
S
F
L
F
K
K
N
K
I
D
G
F
Q
G
T
G
------
K
V
L
G
-----
Q
G
-
K
V
S
V
T
N
EKG--------
E
---
E
---
Q
V
L
E
A
K
N
V
V
I
A
T
G
S
D
V
A
G
I
P
G
V
E
--
V
A
F
D
E
---
K
T
I
V
S
S
T
G
A
L
A
L
E
-
K
-
V
P
A
S
M
I
V
V
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
K
V
T
V
V
E
F
L
D
T
I
L
G
-
G
-
M
D
G
E
V
A
K
Q
L
Q
R
M
L
T
K
-
Q
G
I
D
F
K
L
G
A
K
V
T
-
G
A
V
K
S
G
--
D
-
G
-
A
K
V
T
---
F
E
P
V
K
G
G
E
A
T
T
L
D
A
E
V
V
L
I
A
T
G
R
K
P
S
T
D
G
L
-
G
L
A
K
-
A
G
V
V
L
D
S
R
G
R
V
E
I
D
R
H
F
Q
T
S
I
A
G
V
Y
A
I
G
D
V
V
R
-
G
-
P
M
L
A
H
K
A
E
D
E
G
V
A
V
A
E
I
I
A
G
Q
A
G
--
H
V
--
N
Y
D
V
I
P
G
V
V
Y
T
Q
P
E
V
A
S
V
G
K
T
E
E
E
L
K
A
A
G
V
A
Y
K
I
G
K
F
P
F
T
A
N
G
R
A
R
A
M
L
Q
T
D
G
F
V
K
I
L
A
D
K
E
T
D
R
V
L
G
G
H
I
I
G
F
G
A
G
E
M
I
H
E
I
A
V
L
M
E
F
G
G
S
S
E
D
L
G
R
T
C
H
A
H
P
T
M
S
E
A
V
K
E
A
A
L
S
T
F
F
--
104
HHSearch
94.09
50%
-103
* C3 *
1ZMD
3
DLDH_HUMAN
A:
[5-468]
-
I
D
A
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
K
------
N
------
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
-
H
Y
Y
----
H
M
A
H
G
-
T
D
F
A
S
R
G
I
E
M
-
S
-
E
-
V
R
L
N
L
D
K
M
M
E
Q
K
S
T
A
V
K
A
L
T
G
--
G
I
A
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
------
K
I
T
G
--
K
-
N
Q
V
-
T
A
T
K
-------------
A
DG
G
T
---
Q
V
I
D
T
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
--
I
--
D
E
---
D
T
I
V
S
S
T
G
A
L
S
L
K
-
K
-
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
T
A
V
E
F
L
G
H
V
G
G
V
G
-
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
-
Q
G
F
K
F
K
L
N
T
K
V
T
-
G
A
T
K
K
S
--
D
G
K
-
I
D
V
S
---
I
E
A
A
S
G
G
K
A
E
V
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
-
G
L
E
E
-
L
G
I
E
L
D
P
R
G
R
I
P
V
N
T
R
F
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
-
G
-
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
M
A
G
G
A
V
--
H
I
--
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
N
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
A
A
S
F
G
K
59
PsiBlast_CBE
94.03
47%
-109
- C3 -
2QAE
2
DLDH_TRYCR
B:
[1-464]
-
N
P
Y
D
V
V
V
I
G
G
G
P
G
G
Y
V
A
S
I
K
A
A
Q
L
G
M
K
T
A
C
V
E
K
------
R
------
G
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
T
-
H
L
Y
----
H
D
A
H
--
A
N
F
A
R
Y
G
L
M
G
-
G
-
E
G
V
T
M
D
S
A
K
M
Q
Q
Q
K
E
R
A
V
K
G
L
T
G
--
G
V
E
Y
L
F
K
K
N
K
V
T
Y
Y
K
G
E
G
---------
S
F
E
T
A
H
S
I
-
R
V
N
G
-------------
L
---
D
GKQ
E
M
L
E
T
K
K
T
I
I
A
T
G
S
E
P
T
E
L
P
F
L
P
--
F
--
D
E
---
K
V
V
L
S
S
T
G
A
L
A
L
P
-
R
-
V
P
K
T
M
V
V
I
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
V
E
F
A
P
R
C
A
P
-
T
-
L
D
E
D
V
T
N
A
L
V
G
A
L
A
K
N
E
K
M
K
F
M
T
S
T
K
V
V
-
G
G
T
N
N
G
--
D
-
S
-
V
S
L
E
---
V
E
----
G
K
R
E
T
V
T
C
E
A
L
L
V
S
V
G
R
R
P
F
T
G
G
L
-
G
L
D
K
I
N
-
V
A
K
N
E
R
G
F
V
K
I
G
D
H
F
E
T
S
I
P
D
V
Y
A
I
G
D
V
V
D
K
G
-
P
M
L
A
H
K
A
E
D
E
G
V
A
C
A
E
I
L
A
G
K
P
G
--
H
V
--
N
Y
G
V
I
P
A
V
I
Y
T
M
P
E
V
A
S
V
G
K
S
E
D
E
L
K
K
E
G
V
A
Y
K
V
G
K
F
P
F
N
A
N
S
R
A
K
A
V
S
T
E
D
G
F
V
K
V
L
V
D
K
A
T
D
R
I
L
G
V
H
I
V
C
T
T
A
G
E
L
I
G
E
A
C
L
A
M
E
Y
G
A
S
S
E
D
V
G
R
T
C
H
A
H
P
T
M
S
E
A
L
K
E
A
C
M
A
L
F
A
K
T
10
PsiBlast_PDB
93.75
47%
-109
- C3 -
2QAE
2
DLDH_TRYCR
A:
[1-464]
-
N
P
Y
D
V
V
V
I
G
G
G
P
G
G
Y
V
A
S
I
K
A
A
Q
L
G
M
K
T
A
C
V
E
K
------
R
------
G
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
T
-
H
L
Y
----
H
D
A
H
--
A
N
F
A
R
Y
G
L
M
G
-
G
-
E
G
V
T
M
D
S
A
K
M
Q
Q
Q
K
E
R
A
V
K
G
L
T
G
--
G
V
E
Y
L
F
K
K
N
K
V
T
Y
Y
K
G
E
G
---------
S
F
E
T
A
H
S
I
-
R
V
N
G
-------------
L
---
D
G
K
Q
E
M
L
E
T
K
K
T
I
I
A
T
G
S
E
P
T
E
L
P
F
L
P
--
F
--
D
E
---
K
V
V
L
S
S
T
G
A
L
A
L
P
-
R
-
V
P
K
T
M
V
V
I
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
V
E
F
A
P
R
C
A
P
-
T
-
L
D
E
D
V
T
N
A
L
V
G
A
L
A
K
N
E
K
M
K
F
M
T
S
T
K
V
V
-
G
G
T
N
N
G
--
D
-
S
-
V
S
L
E
---
V
E
----
G
K
R
E
T
V
T
C
E
A
L
L
V
S
V
G
R
R
P
F
T
G
G
L
-
G
L
D
K
I
N
-
V
A
K
N
E
R
G
F
V
K
I
G
D
H
F
E
T
S
I
P
D
V
Y
A
I
G
D
V
V
D
K
G
-
P
M
L
A
H
K
A
E
D
E
G
V
A
C
A
E
I
L
A
G
K
P
G
--
H
V
--
N
Y
G
V
I
P
A
V
I
Y
T
M
P
E
V
A
S
V
G
K
S
E
D
E
L
K
K
E
G
V
A
Y
K
V
G
K
F
P
F
N
A
N
S
R
A
K
A
V
S
T
E
D
G
F
V
K
V
L
V
D
K
A
T
D
R
I
L
G
V
H
I
V
C
T
T
A
G
E
L
I
G
E
A
C
L
A
M
E
Y
G
A
S
S
E
D
V
G
R
T
C
H
A
H
P
T
M
S
E
A
L
K
E
A
C
M
A
L
F
A
K
T
105
HHSearch
93.36
48%
-102
- C3 -
1V59
4
DLDH_YEAST
A:
[3-473]
N
K
S
H
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
L
G
F
N
T
A
C
V
E
K
------
R
------
G
K
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
-
H
L
F
----
H
Q
M
H
--
T
E
A
Q
K
R
G
I
D
V
N
G
-
D
-
I
K
I
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
--
G
I
E
L
L
F
K
K
N
K
V
T
Y
Y
K
G
N
G
------
S
F
E
D
--
E
-
T
K
I
-
R
V
T
P
V
DGLEGTVK----
E
---
D
---
H
I
L
D
V
K
N
I
I
V
A
T
G
S
E
V
T
P
F
P
G
I
E
--
I
--
D
E
---
E
K
I
V
S
S
T
G
A
L
S
L
K
-
E
-
I
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
A
-
S
-
M
D
G
E
V
A
K
A
T
Q
K
F
L
K
K
-
Q
G
L
D
F
K
L
S
T
K
V
I
-
S
A
K
R
N
D
--
D
K
N
V
V
E
I
V
---
V
E
D
T
K
T
N
K
Q
E
N
L
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
-
G
A
E
K
-
I
G
L
E
V
D
K
R
G
R
L
V
I
D
D
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
V
T
F
-
G
-
P
M
L
A
H
K
A
E
E
E
G
I
A
A
V
E
M
L
K
T
G
H
G
--
H
V
--
N
Y
N
N
I
P
S
V
M
Y
S
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
I
D
Y
K
I
G
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
N
A
G
E
M
I
A
E
A
G
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
C
H
A
H
P
T
L
S
E
A
F
K
E
A
N
M
A
A
Y
D
K
A
102
HHSearch
92.75
48%
-106
- C3 -
2QAE
2
DLDH_TRYCR
A:
[1-464]
-
N
P
Y
D
V
V
V
I
G
G
G
P
G
G
Y
V
A
S
I
K
A
A
Q
L
G
M
K
T
A
C
V
E
K
------
R
------
G
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
T
-
H
L
Y
----
H
D
A
H
--
A
N
F
A
R
Y
G
L
M
G
G
E
-
G
-
V
T
M
D
S
A
K
M
Q
Q
Q
K
E
R
A
V
K
G
L
T
G
--
G
V
E
Y
L
F
K
K
N
K
V
T
Y
Y
K
G
E
G
------
S
F
E
T
--
A
-
H
S
I
-
R
V
N
G
LDG----------
K
---
Q
---
E
M
L
E
T
K
K
T
I
I
A
T
G
S
E
P
T
E
L
---
P
--
F
--
L
P
FDE
K
V
V
L
S
S
T
G
A
L
A
L
P
-
R
-
V
P
K
T
M
V
V
I
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
V
E
F
A
P
R
C
A
P
-
T
-
L
D
E
D
V
T
N
A
L
V
G
A
L
A
K
N
E
K
M
K
F
M
T
S
T
K
V
V
-
G
G
T
N
N
G
--
D
-
S
-
V
S
L
E
---
V
E
----
G
K
R
E
T
V
T
C
E
A
L
L
V
S
V
G
R
R
P
F
T
G
G
L
-
G
L
D
K
-
I
N
V
A
K
N
E
R
G
F
V
K
I
G
D
H
F
E
T
S
I
P
D
V
Y
A
I
G
D
V
V
D
-
K
G
P
M
L
A
H
K
A
E
D
E
G
V
A
C
A
E
I
L
A
G
K
P
G
--
H
V
--
N
Y
G
V
I
P
A
V
I
Y
T
M
P
E
V
A
S
V
G
K
S
E
D
E
L
K
K
E
G
V
A
Y
K
V
G
K
F
P
F
N
A
N
S
R
A
K
A
V
S
T
E
D
G
F
V
K
V
L
V
D
K
A
T
D
R
I
L
G
V
H
I
V
C
T
T
A
G
E
L
I
G
E
A
C
L
A
M
E
Y
G
A
S
S
E
D
V
G
R
T
C
H
A
H
P
T
M
S
E
A
L
K
E
A
C
M
A
L
F
A
K
T
9
PsiBlast_PDB
92.17
47%
-102
- C3 -
1V59
4
DLDH_YEAST
A:
[5-474]
--
S
H
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
L
G
F
N
T
A
C
V
E
K
------
R
------
G
K
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
-
H
L
F
----
H
Q
M
H
--
T
E
A
Q
K
R
G
I
D
V
-
N
G
D
-
I
K
I
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
--
G
I
E
L
L
F
K
K
N
K
V
T
Y
Y
K
G
N
G
S
F
EDET
K
I
R
V
T
P
V
-
D
G
L
-
E
G
T
V
K------------
E
---
D
---
H
I
L
D
V
K
N
I
I
V
A
T
G
S
E
V
T
P
F
P
G
I
E
--
I
--
D
E
---
E
K
I
V
S
S
T
G
A
L
S
L
K
-
E
-
I
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
A
-
S
-
M
D
G
E
V
A
K
A
T
Q
K
F
L
K
K
-
Q
G
L
D
F
K
L
S
T
K
V
I
-
S
A
K
R
N
D
DK
N
-
V
-
V
E
I
V
---
V
E
D
T
K
T
N
K
Q
E
N
L
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
-
G
A
E
K
I
G
-
L
E
V
D
K
R
G
R
L
V
I
D
D
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
V
T
F
-
G
-
P
M
L
A
H
K
A
E
E
E
G
I
A
A
V
E
M
L
K
T
G
H
G
--
H
V
--
N
Y
N
N
I
P
S
V
M
Y
S
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
I
D
Y
K
I
G
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
N
A
G
E
M
I
A
E
A
G
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
C
H
A
H
P
T
L
S
E
A
F
K
E
A
N
M
A
A
Y
D
K
A
54
PsiBlast_CBE
92.15
49%
-103
- C3 -
1ZY8
2
DLDH_HUMAN
D:
[8-470]
----
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
K
------
N
------
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
-
H
Y
Y
H---
M
A
H
G
--
K
D
F
A
S
R
G
I
E
M
-
S
-
E
-
V
R
L
N
L
D
K
M
M
E
Q
K
S
T
A
V
K
A
L
T
G
--
G
I
A
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
------
K
I
T
G
K
N
Q
V
T
A
T
-
K
A
D
G
-------------
G
---
T
---
Q
V
I
D
T
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
--
I
--
D
E
---
D
T
I
V
S
S
T
G
A
L
S
L
K
-
K
-
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
T
A
V
E
F
L
G
H
V
G
G
-
V
G
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
-
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
K
K
S
D
--
G
-
K
-
I
D
V
S
---
I
E
A
A
S
G
G
K
A
E
V
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
-
G
L
E
E
L
G
-
I
E
L
D
P
R
G
R
I
P
V
N
T
R
F
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
-
G
-
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
M
A
G
G
A
V
--
H
I
--
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
N
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
A
A
S
F
G
K
46
PsiBlast_CBE
92.00
49%
-100
- C3 -
1ZMC
4
DLDH_HUMAN
B:
[8-470]
----
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
K
------
N
------
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
-
H
Y
Y
H
---
M
A
H
G
--
T
D
F
A
S
R
G
I
E
M
-
S
-
E
-
V
R
L
N
L
D
K
M
M
E
Q
K
S
T
A
V
K
A
L
T
G
--
G
I
A
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
------
K
I
T
G
K
N
Q
V
T
A
T
-
K
A
D
G
-------------
G
---
T
---
Q
V
I
D
T
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
--
I
--
D
E
---
D
T
I
V
S
S
T
G
A
L
S
L
K
-
K
-
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
T
A
V
E
F
L
G
H
V
G
G
-
V
G
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
-
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
K
K
S
D
--
G
-
K
-
I
D
V
S
---
I
E
A
A
S
G
G
K
A
E
V
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
-
G
L
E
E
L
G
-
I
E
L
D
P
R
G
R
I
P
V
N
T
R
F
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
-
G
-
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
M
A
G
G
A
V
--
H
I
--
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
N
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
A
A
S
F
G
K
31
PsiBlast_CBE
91.67
49%
-101
- C3 -
2F5Z
4
DLDH_HUMAN
C:
[8-470]
----
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
K
------
N
------
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
-
H
Y
Y
H
---
M
A
H
G
--
T
D
F
A
S
R
G
I
E
M
-
S
-
E
-
V
R
L
N
L
D
K
M
M
E
Q
K
S
T
A
V
K
A
L
T
G
--
G
I
A
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
------
K
I
T
G
K
N
Q
V
T
A
T
-
K
A
D
G
-------------
G
---
T
---
Q
V
I
D
T
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
--
I
--
D
E
---
D
T
I
V
S
S
T
G
A
L
S
L
K
-
K
-
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
T
A
V
E
F
L
G
H
V
G
G
-
V
G
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
-
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
K
K
S
D
--
G
-
K
-
I
D
V
S
---
I
E
A
A
S
G
G
K
A
E
V
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
-
G
L
E
E
L
G
-
I
E
L
D
P
R
G
R
I
P
V
N
T
R
F
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
-
G
-
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
M
A
G
G
A
V
--
H
I
--
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
N
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
A
A
S
F
G
K
43
PsiBlast_CBE
91.63
49%
-98
- C3 -
1ZMC
1
DLDH_HUMAN
E:
[8-470]
----
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
K
------
N
------
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
-
H
Y
Y
H---
M
A
H
G
--
T
D
F
A
S
R
G
I
E
M
-
S
-
E
-
V
R
L
N
L
D
K
M
M
E
Q
K
S
T
A
V
K
A
L
T
G
--
G
I
A
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
------
K
I
T
G
K
N
Q
V
T
A
T
-
K
A
D
G
-------------
G
---
T
---
Q
V
I
D
T
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
--
I
--
D
E
---
D
T
I
V
S
S
T
G
A
L
S
L
K
-
K
-
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
T
A
V
E
F
L
G
H
V
G
G
-
V
G
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
-
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
K
K
S
D
--
G
-
K
-
I
D
V
S
---
I
E
A
A
S
G
G
K
A
E
V
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
-
G
L
E
E
L
G
-
I
E
L
D
P
R
G
R
I
P
V
N
T
R
F
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
-
G
-
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
M
A
G
G
A
V
--
H
I
--
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
N
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
A
A
S
F
G
K
39
PsiBlast_CBE
91.42
49%
-101
- C3 -
1ZMD
4
DLDH_HUMAN
B:
[8-470]
----
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
K
------
N
------
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
-
H
Y
Y
H
---
M
A
H
G
--
T
D
F
A
S
R
G
I
E
M
-
S
-
E
-
V
R
L
N
L
D
K
M
M
E
Q
K
S
T
A
V
K
A
L
T
G
--
G
I
A
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
------
K
I
T
G
K
N
Q
V
T
A
T
-
K
A
D
G
-------------
G
---
T
---
Q
V
I
D
T
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
--
I
--
D
E
---
D
T
I
V
S
S
T
G
A
L
S
L
K
-
K
-
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
T
A
V
E
F
L
G
H
V
G
G
-
V
G
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
-
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
K
K
S
D
--
G
-
K
-
I
D
V
S
---
I
E
A
A
S
G
G
K
A
E
V
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
-
G
L
E
E
L
G
-
I
E
L
D
P
R
G
R
I
P
V
N
T
R
F
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
-
G
-
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
M
A
G
G
A
V
--
H
I
--
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
N
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
A
A
S
F
G
K
36
PsiBlast_CBE
91.42
49%
-99
- C3 -
1ZMD
3
DLDH_HUMAN
E:
[8-470]
----
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
K
------
N
------
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
-
H
Y
Y
H---
M
A
H
G
--
T
D
F
A
S
R
G
I
E
M
-
S
-
E
-
V
R
L
N
L
D
K
M
M
E
Q
K
S
T
A
V
K
A
L
T
G
--
G
I
A
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
------
K
I
T
G
K
N
Q
V
T
A
T
-
K
A
D
G
-------------
G
---
T
---
Q
V
I
D
T
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
--
I
--
D
E
---
D
T
I
V
S
S
T
G
A
L
S
L
K
-
K
-
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
T
A
V
E
F
L
G
H
V
G
G
-
V
G
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
-
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
K
K
S
D
--
G
-
K
-
I
D
V
S
---
I
E
A
A
S
G
G
K
A
E
V
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
-
G
L
E
E
L
G
-
I
E
L
D
P
R
G
R
I
P
V
N
T
R
F
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
-
G
-
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
M
A
G
G
A
V
--
H
I
--
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
N
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
A
A
S
F
G
K
33
PsiBlast_CBE
91.31
49%
-99
- C3 -
1ZMD
20
DLDH_HUMAN
H:
[8-470]
----
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
K
------
N
------
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
-
H
Y
Y
H---
M
A
H
G
--
T
D
F
A
S
R
G
I
E
M
-
S
-
E
-
V
R
L
N
L
D
K
M
M
E
Q
K
S
T
A
V
K
A
L
T
G
--
G
I
A
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
------
K
I
T
G
K
N
Q
V
T
A
T
-
K
A
D
G
-------------
G
---
T
---
Q
V
I
D
T
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
--
I
--
D
E
---
D
T
I
V
S
S
T
G
A
L
S
L
K
-
K
-
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
T
A
V
E
F
L
G
H
V
G
G
-
V
G
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
-
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
K
K
S
D
--
G
-
K
-
I
D
V
S
---
I
E
A
A
S
G
G
K
A
E
V
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
-
G
L
E
E
L
G
-
I
E
L
D
P
R
G
R
I
P
V
N
T
R
F
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
-
G
-
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
M
A
G
G
A
V
--
H
I
--
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
N
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
A
A
S
F
G
K
45
PsiBlast_CBE
91.29
49%
-99
- C3 -
1ZMC
4
DLDH_HUMAN
C:
[8-470]
----
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
K
------
N
------
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
-
H
Y
Y
H
---
M
A
H
G
--
T
D
F
A
S
R
G
I
E
M
-
S
-
E
-
V
R
L
N
L
D
K
M
M
E
Q
K
S
T
A
V
K
A
L
T
G
--
G
I
A
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
------
K
I
T
G
K
N
Q
V
T
A
T
-
K
A
D
G
-------------
G
---
T
---
Q
V
I
D
T
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
--
I
--
D
E
---
D
T
I
V
S
S
T
G
A
L
S
L
K
-
K
-
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
T
A
V
E
F
L
G
H
V
G
G
-
V
G
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
-
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
K
K
S
D
--
G
-
K
-
I
D
V
S
---
I
E
A
A
S
G
G
K
A
E
V
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
-
G
L
E
E
L
G
-
I
E
L
D
P
R
G
R
I
P
V
N
T
R
F
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
-
G
-
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
M
A
G
G
A
V
--
H
I
--
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
N
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
A
A
S
F
G
K
21
PsiBlast_CBE
91.26
51%
-103
- C3 -
1DXL
2
DLDH_PEA
D:
[8-466]
----
D
V
V
I
I
G
G
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
T
C
I
E
K
------
R
------
G
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
S
S
-
H
M
Y
----
H
E
A
K
--
H
S
F
A
N
H
G
V
K
V
-
S
-
N
-
V
E
I
D
L
A
A
M
M
G
Q
K
D
K
A
V
S
N
L
T
R
--
G
I
E
G
L
F
K
K
N
K
V
T
Y
V
K
G
Y
G
------
K
F
V
S
P
S
E
-
I
S
V
D
T
I
E
G
-------------
E
---
N
---
T
V
V
K
G
K
H
I
I
I
A
T
G
S
D
V
K
S
L
P
G
V
T
--
I
--
D
E
---
K
K
I
V
S
S
T
G
A
L
A
L
S
-
E
-
I
P
K
K
L
V
V
I
G
A
G
Y
I
G
L
E
M
G
S
V
W
G
R
I
G
S
E
V
T
V
V
E
F
A
S
E
I
V
P
-
T
-
M
D
A
E
I
R
K
Q
F
Q
R
S
L
E
K
-
Q
G
M
K
F
K
L
K
T
K
V
V
-
G
V
D
T
S
G
--
D
-
G
-
V
K
L
T
---
V
E
P
S
A
G
G
E
Q
T
I
I
E
A
D
V
V
L
V
S
A
G
R
T
P
F
T
S
G
L
-
N
L
D
K
I
G
-
V
E
T
D
K
L
G
R
I
L
V
N
E
R
F
S
T
N
V
S
G
V
Y
A
I
G
D
V
I
P
-
G
-
P
M
L
A
H
K
A
E
E
D
G
V
A
C
V
E
Y
L
A
G
K
V
G
--
H
V
--
D
Y
D
K
V
P
G
V
V
Y
T
N
P
E
V
A
S
V
G
K
T
E
E
Q
V
K
E
T
G
V
E
Y
R
V
G
K
F
P
F
M
A
N
S
R
A
K
A
I
D
N
A
E
G
L
V
K
I
I
A
E
K
E
T
D
K
I
L
G
V
H
I
M
A
P
N
A
G
E
L
I
H
E
A
A
I
A
L
Q
Y
D
A
S
S
E
D
I
A
R
V
C
H
A
H
P
T
M
S
E
A
I
K
E
A
A
M
A
T
Y
D
K
P
24
PsiBlast_CBE
91.23
49%
-98
- C3 -
2F5Z
18
DLDH_HUMAN
J:
[8-470]
----
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
K
------
N
------
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
-
H
Y
Y
H---
M
A
H
G
--
T
D
F
A
S
R
G
I
E
M
-
S
-
E
-
V
R
L
N
L
D
K
M
M
E
Q
K
S
T
A
V
K
A
L
T
G
--
G
I
A
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
------
K
I
T
G
K
N
Q
V
T
A
T
-
K
A
D
G
-------------
G
---
T
---
Q
V
I
D
T
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
--
I
--
D
E
---
D
T
I
V
S
S
T
G
A
L
S
L
K
-
K
-
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
T
A
V
E
F
L
G
H
V
G
G
-
V
G
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
-
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
K
K
S
D
--
G
-
K
-
I
D
V
S
---
I
E
A
A
S
G
G
K
A
E
V
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
-
G
L
E
E
L
G
-
I
E
L
D
P
R
G
R
I
P
V
N
T
R
F
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
-
G
-
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
M
A
G
G
A
V
--
H
I
--
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
N
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
A
A
S
F
G
K
8
PsiBlast_PDB
90.97
47%
-103
- C3 -
1JEH
2
DLDH_YEAST
A:
[5-474]
--
S
H
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
L
G
F
N
T
A
C
V
E
K
------
R
------
G
K
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
-
H
L
F
----
H
Q
M
H
--
T
E
A
Q
K
R
G
I
D
V
-
N
G
D
-
I
K
I
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
--
G
I
E
L
L
F
K
K
N
K
V
T
Y
Y
K
G
N
G
S
F
EDET
K
I
R
V
T
P
V
-
D
G
L
-
E
G
T
V
K------------
E
---
D
---
H
I
L
D
V
K
N
I
I
V
A
T
G
S
E
V
T
P
F
P
G
I
E
--
I
--
D
E
---
E
K
I
V
S
S
T
G
A
L
S
L
K
-
E
-
I
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
A
-
S
-
M
D
G
E
V
A
K
A
T
Q
K
F
L
K
K
-
Q
G
L
D
F
K
L
S
T
K
V
I
-
S
A
K
R
N
D
DK
N
-
V
-
V
E
I
V
---
V
E
D
T
K
T
N
K
Q
E
N
L
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
-
G
A
E
K
I
G
-
L
E
V
D
K
R
G
R
L
V
I
D
D
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
V
T
F
-
G
-
P
M
L
A
H
K
A
E
E
E
G
I
A
A
V
E
M
L
K
T
G
H
G
--
H
V
--
N
Y
N
N
I
P
S
V
M
Y
S
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
I
D
Y
K
I
G
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
N
A
G
E
M
I
A
E
A
G
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
C
H
A
H
P
T
L
S
E
A
F
K
E
A
N
M
A
A
Y
D
K
A
2
PsiBlast_PDB
90.83
49%
-98
- C3 -
1ZMC
4
DLDH_HUMAN
A:
[8-470]
----
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
F
K
T
V
C
I
E
K
------
N
------
E
T
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
-
H
Y
Y
H
---
M
A
H
G
--
T
D
F
A
S
R
G
I
E
M
-
S
-
E
-
V
R
L
N
L
D
K
M
M
E
Q
K
S
T
A
V
K
A
L
T
G
--
G
I
A
H
L
F
K
Q
N
K
V
V
H
V
N
G
Y
G
------
K
I
T
G
K
N
Q
V
T
A
T
-
K
A
D
G
-------------
G
---
T
---
Q
V
I
D
T
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
--
I
--
D
E
---
D
T
I
V
S
S
T
G
A
L
S
L
K
-
K
-
V
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
T
A
V
E
F
L
G
H
V
G
G
-
V
G
I
D
M
E
I
S
K
N
F
Q
R
I
L
Q
K
-
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
K
K
S
D
--
G
-
K
-
I
D
V
S
---
I
E
A
A
S
G
G
K
A
E
V
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
-
G
L
E
E
L
G
-
I
E
L
D
P
R
G
R
I
P
V
N
T
R
F
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
-
G
-
P
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
M
A
G
G
A
V
--
H
I
--
D
Y
N
C
V
P
S
V
I
Y
T
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
N
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
A
A
S
F
G
K
58
PsiBlast_CBE
90.23
47%
-100
- C3 -
1JEH
2
DLDH_YEAST
B:
[5-474]
--
S
H
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
L
G
F
N
T
A
C
V
E
K
------
R
------
G
K
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
-
H
L
F
----
H
Q
M
H
--
T
E
A
Q
K
R
G
I
D
V
-
N
G
D
-
I
K
I
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
--
G
I
E
L
L
F
K
K
N
K
V
T
Y
Y
K
G
N
G
SFEDET
K
I
R
V
T
P
V
-
D
G
L
-
E
G
T
V
K------------
E
---
D
---
H
I
L
D
V
K
N
I
I
V
A
T
G
S
E
V
T
P
F
P
G
I
E
--
I
--
D
E
---
E
K
I
V
S
S
T
G
A
L
S
L
K
-
E
-
I
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
A
-
S
-
M
D
G
E
V
A
K
A
T
Q
K
F
L
K
K
-
Q
G
L
D
F
K
L
S
T
K
V
I
-
S
A
K
R
N
D
DK
N
-
V
-
V
E
I
V
---
V
E
D
T
K
T
N
K
Q
E
N
L
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
-
G
A
E
K
I
G
-
L
E
V
D
K
R
G
R
L
V
I
D
D
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
V
T
F
-
G
-
P
M
L
A
H
K
A
E
E
E
G
I
A
A
V
E
M
L
K
T
G
H
G
--
H
V
--
N
Y
N
N
I
P
S
V
M
Y
S
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
I
D
Y
K
I
G
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
N
A
G
E
M
I
A
E
A
G
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
C
H
A
H
P
T
L
S
E
A
F
K
E
A
N
M
A
A
Y
D
K
A
57
PsiBlast_CBE
89.73
47%
-103
- C3 -
1V59
3
DLDH_YEAST
B:
[5-474]
--
S
H
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
L
G
F
N
T
A
C
V
E
K
------
R
------
G
K
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
-
H
L
F
----
H
Q
M
H
--
T
E
A
Q
K
R
G
I
D
V
-
N
G
D
-
I
K
I
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
--
G
I
E
L
L
F
K
K
N
K
V
T
Y
Y
K
G
N
G
SFEDET
K
I
R
V
T
P
V
-
D
G
L
-
E
G
T
V
K------------
E
---
D
---
H
I
L
D
V
K
N
I
I
V
A
T
G
S
E
V
T
P
F
P
G
I
E
--
I
--
D
E
---
E
K
I
V
S
S
T
G
A
L
S
L
K
-
E
-
I
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
A
-
S
-
M
D
G
E
V
A
K
A
T
Q
K
F
L
K
K
-
Q
G
L
D
F
K
L
S
T
K
V
I
-
S
A
K
R
N
D
DK
N
-
V
-
V
E
I
V
---
V
E
D
T
K
T
N
K
Q
E
N
L
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
-
G
A
E
K
I
G
-
L
E
V
D
K
R
G
R
L
V
I
D
D
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
V
T
F
-
G
-
P
M
L
A
H
K
A
E
E
E
G
I
A
A
V
E
M
L
K
T
G
H
G
--
H
V
--
N
Y
N
N
I
P
S
V
M
Y
S
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
I
D
Y
K
I
G
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
N
A
G
E
M
I
A
E
A
G
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
C
H
A
H
P
T
L
S
E
A
F
K
E
A
N
M
A
A
Y
D
K
A
61
PsiBlast_CBE
89.71
44%
-104
- C3 -
2EQ7
3
?
B:
[2-449]
---
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
------
E
------
K
A
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
-
E
R
I
----
Y
E
A
K
--
K
G
L
--
L
G
A
K
V
-
K
-
G
-
V
E
L
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
--
G
V
E
F
L
F
K
K
N
G
I
A
R
H
Q
G
T
A
------
R
F
L
S
-----
E
R
-
K
V
L
V
-------------
E
---
E
TG-
E
E
L
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
W
A
Q
--
V
--
D
Y
---
E
R
V
V
T
S
T
E
A
L
S
F
P
-
E
-
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
-
T
-
M
D
L
E
V
S
R
A
A
E
R
V
F
K
K
-
Q
G
L
T
I
R
T
G
V
R
V
T
-
A
V
V
P
E
A
--
K
-
G
-
A
R
V
E
---
L
E
G
-----
G
E
V
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
-
S
L
E
N
-
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
-
G
-
P
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
R
G
F
G
--
H
V
--
D
Y
Q
A
I
P
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
S
L
S
E
I
L
K
E
A
A
L
A
A
W
E
R
P
14
PsiBlast_PDB
89.43
42%
-109
- C3 -
3LAD
2
DLDH_AZOVI
A:
[2-462]
-
Q
K
F
D
V
I
V
I
G
A
G
P
G
G
Y
V
A
A
I
K
S
A
Q
L
G
L
K
T
A
L
I
E
K
YKGKEG
K
------
T
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
-
Y
K
F
----
H
E
A
H
--
E
S
F
K
L
H
G
I
S
T
-
G
-
E
-
V
A
I
D
V
P
T
M
I
A
R
K
D
Q
I
V
R
N
L
T
G
--
G
V
A
S
L
I
K
A
N
G
V
T
L
F
E
G
H
G
------
K
L
L
A
G
K
K
---
V
-
E
V
T
A
-------------
A
---
D
GS
S
Q
V
L
D
T
E
N
V
I
L
A
S
G
S
K
P
V
E
I
P
P
A
P
--
V
--
D
Q
---
D
V
I
V
D
S
T
G
A
L
D
F
Q
-
N
-
V
P
G
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
M
D
K
F
L
P
-
A
-
V
D
E
Q
V
A
K
E
A
Q
K
I
L
T
K
-
Q
G
L
K
I
L
L
G
A
R
V
T
-
G
T
E
V
K
N
--
K
-
Q
-
V
T
V
K
---
F
V
D
A
E
G
E
K
S
Q
A
F
--
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
-
G
-
V
T
L
D
E
R
G
F
I
Y
V
D
D
Y
C
A
T
S
V
P
G
V
Y
A
I
G
D
V
V
R
-
G
-
A
M
L
A
H
K
A
S
E
E
G
V
V
V
A
E
R
I
A
G
H
K
A
--
Q
M
--
N
Y
D
L
I
P
A
V
I
Y
T
H
P
E
I
A
G
V
G
K
T
E
Q
A
L
K
A
E
G
V
A
I
N
V
G
V
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
A
G
F
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
A
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
A
H
P
A
L
S
E
A
L
H
E
A
A
L
A
V
S
G
H
A
13
PsiBlast_PDB
89.27
44%
-103
- C3 -
1LPF
2
DLDH_PSEFL
A:
[2-462]
-
Q
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
K
YIGKEG
K
------
V
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
-
Y
K
Y
----
H
E
A
K
--
E
A
F
K
V
H
G
I
E
A
-
K
-
G
-
V
T
I
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
--
G
I
A
T
L
F
K
A
N
G
V
T
S
F
E
G
H
G
------
K
L
L
A
N
K
Q
V
E
V
T
-
G
L
D
G
-------------
K
---
T
---
Q
V
L
E
A
E
N
V
I
I
A
S
G
S
R
P
V
E
I
P
P
A
P
--
L
--
S
D
---
D
I
I
V
D
S
T
G
A
L
E
F
Q
-
A
-
V
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
-
A
-
A
D
E
Q
I
A
K
E
A
L
K
V
L
T
K
-
Q
G
L
N
I
R
L
G
A
R
V
T
-
A
S
E
V
K
K
--
K
-
Q
-
V
T
V
T
---
F
T
D
A
N
G
E
Q
K
E
T
F
--
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
-
G
-
V
T
L
D
E
R
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
V
V
R
-
G
-
A
M
L
A
H
K
A
S
E
E
G
V
M
V
A
E
R
I
A
G
H
K
A
--
Q
M
--
N
Y
D
L
I
P
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
V
E
V
N
V
G
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
T
G
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
T
L
S
E
A
L
H
E
A
A
L
A
V
N
G
H
A
12
PsiBlast_PDB
89.08
44%
-107
- C3 -
2YQU
4
?
A:
[2-449]
---
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
------
E
------
K
A
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
-
E
R
I
----
Y
E
A
K
--
K
G
L
--
L
G
A
K
V
-
K
-
G
-
V
E
L
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
--
G
V
E
F
L
F
K
K
N
G
I
A
R
H
Q
G
T
A
------
R
F
L
S
-----
E
R
-
K
V
L
V
-------------
E
---
E
TG-
E
E
L
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
W
A
Q
--
V
--
D
Y
---
E
R
V
V
T
S
T
E
A
L
S
F
P
-
E
-
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
-
T
-
M
D
L
E
V
S
R
A
A
E
R
V
F
K
K
-
Q
G
L
T
I
R
T
G
V
R
V
T
-
A
V
V
P
E
A
--
K
-
G
-
A
R
V
E
---
L
E
G
-----
G
E
V
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
-
S
L
E
N
-
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
-
G
-
P
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
R
G
F
G
--
H
V
--
D
Y
Q
A
I
P
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
S
L
S
E
I
L
K
E
A
A
L
A
A
W
E
R
P
60
PsiBlast_CBE
88.61
44%
-105
- C3 -
2YQU
6
?
B:
[2-449]
---
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
------
E
------
K
A
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
-
E
R
I
----
Y
E
A
K
--
K
G
L
--
L
G
A
K
V
-
K
-
G
-
V
E
L
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
--
G
V
E
F
L
F
K
K
N
G
I
A
R
H
Q
G
T
A
------
R
F
L
S
-----
E
R
-
K
V
L
V
-------------
E
---
E
TG-
E
E
L
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
W
A
Q
--
V
--
D
Y
---
E
R
V
V
T
S
T
E
A
L
S
F
P
-
E
-
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
-
T
-
M
D
L
E
V
S
R
A
A
E
R
V
F
K
K
-
Q
G
L
T
I
R
T
G
V
R
V
T
-
A
V
V
P
E
A
--
K
-
G
-
A
R
V
E
---
L
E
G
-----
G
E
V
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
-
S
L
E
N
-
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
-
G
-
P
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
R
G
F
G
--
H
V
--
D
Y
Q
A
I
P
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
S
L
S
E
I
L
K
E
A
A
L
A
A
W
E
R
P
62
PsiBlast_CBE
88.44
44%
-104
- C3 -
1LPF
2
DLDH_PSEFL
B:
[2-462]
-
Q
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
K
YIGKEG
K
------
V
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
-
Y
K
Y
----
H
E
A
K
--
E
A
F
K
V
H
G
I
E
A
-
K
-
G
-
V
T
I
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
--
G
I
A
T
L
F
K
A
N
G
V
T
S
F
E
G
H
G
------
K
L
L
A
N
K
Q
V
E
V
T
-
G
L
D
G
-------------
K
---
T
---
Q
V
L
E
A
E
N
V
I
I
A
S
G
S
R
P
V
E
I
P
P
A
P
--
L
--
S
D
---
D
I
I
V
D
S
T
G
A
L
E
F
Q
-
A
-
V
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
-
A
-
A
D
E
Q
I
A
K
E
A
L
K
V
L
T
K
-
Q
G
L
N
I
R
L
G
A
R
V
T
-
A
S
E
V
K
K
--
K
-
Q
-
V
T
V
T
---
F
T
D
A
N
G
E
Q
K
E
T
F
--
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
-
G
-
V
T
L
D
E
R
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
V
V
R
-
G
-
A
M
L
A
H
K
A
S
E
E
G
V
M
V
A
E
R
I
A
G
H
K
A
--
Q
M
--
N
Y
D
L
I
P
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
V
E
V
N
V
G
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
T
G
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
T
L
S
E
A
L
H
E
A
A
L
A
V
N
G
H
A
63
PsiBlast_CBE
88.37
42%
-107
- C3 -
3LAD
2
DLDH_AZOVI
B:
[2-462]
-
Q
K
F
D
V
I
V
I
G
A
G
P
G
G
Y
V
A
A
I
K
S
A
Q
L
G
L
K
T
A
L
I
E
K
YKGKEG
K
------
T
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
-
Y
K
F
----
H
E
A
H
--
E
S
F
K
L
H
G
I
S
T
-
G
-
E
-
V
A
I
D
V
P
T
M
I
A
R
K
D
Q
I
V
R
N
L
T
G
--
G
V
A
S
L
I
K
A
N
G
V
T
L
F
E
G
H
G
------
K
L
L
A
G
K
K
---
V
-
E
V
T
A
-------------
A
---
D
GSS
Q
V
L
D
T
E
N
V
I
L
A
S
G
S
K
P
V
E
I
P
P
A
P
--
V
--
D
Q
---
D
V
I
V
D
S
T
G
A
L
D
F
Q
-
N
-
V
P
G
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
M
D
K
F
L
P
-
A
-
V
D
E
Q
V
A
K
E
A
Q
K
I
L
T
K
-
Q
G
L
K
I
L
L
G
A
R
V
T
-
G
T
E
V
K
N
--
K
-
Q
-
V
T
V
K
---
F
V
D
A
E
G
E
K
S
Q
A
F
--
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
-
G
-
V
T
L
D
E
R
G
F
I
Y
V
D
D
Y
C
A
T
S
V
P
G
V
Y
A
I
G
D
V
V
R
-
G
-
A
M
L
A
H
K
A
S
E
E
G
V
V
V
A
E
R
I
A
G
H
K
A
--
Q
M
--
N
Y
D
L
I
P
A
V
I
Y
T
H
P
E
I
A
G
V
G
K
T
E
Q
A
L
K
A
E
G
V
A
I
N
V
G
V
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
A
G
F
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
A
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
A
H
P
A
L
S
E
A
L
H
E
A
A
L
A
V
S
G
H
A
112
HHSearch
87.75
44%
-102
- C3 -
2YQU
4
?
A:
[1-451]
--
M
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
------
E
------
K
A
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
-
E
R
I
----
Y
E
A
K
--
K
G
--
L
L
G
A
K
V
-
K
-
G
-
V
E
L
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
--
G
V
E
F
L
F
K
K
N
G
I
A
R
H
Q
G
T
A
------
R
F
L
S
--
E
-
R
K
V
-
L
V
E
E
-------------
T
---
G
---
E
E
L
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
---
P
--
W
--
A
Q
VDY
E
R
V
V
T
S
T
E
A
L
S
F
P
-
E
-
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
-
T
-
M
D
L
E
V
S
R
A
A
E
R
V
F
K
K
-
Q
G
L
T
I
R
T
G
V
R
V
T
-
A
V
V
P
E
A
--
K
-
G
-
A
R
V
E
---
L
-----
E
G
G
E
V
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
-
S
L
E
N
-
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
-
G
-
P
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
R
G
F
G
--
H
V
--
D
Y
Q
A
I
P
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
S
L
S
E
I
L
K
E
A
A
L
A
A
W
E
R
P
74
PsiBlast_CBE
87.27
40%
-104
- C3 -
2EQ6
2
?
B:
[4-457]
M
K
T
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
------
G
------
E
V
-
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
-
E
T
L
----
H
H
L
K
--
V
A
-
E
G
F
G
L
K
A
-
K
-
P
--
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
--
G
V
G
T
L
L
K
G
N
G
V
E
L
L
R
G
F
A
------
R
L
V
G
P
K
E
------
V
E
V
-------------
G
---
G
---
E
R
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
--
F
--
G
E
----
D
V
W
D
S
T
R
A
L
K
V
E
-
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
-
Q
-
G
D
P
E
T
A
A
L
L
R
R
A
L
E
K
-
E
G
I
R
V
R
T
K
T
K
A
V
-
G
Y
E
K
K
K
--
D
-
G
-
L
H
V
R
---
L
E
P
A
E
G
G
E
G
E
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
-
G
L
E
K
-
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
-
P
-
P
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
S
--
A
F
--
D
Y
Q
V
-
P
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
-
E
A
F
H
K
Q
11
PsiBlast_PDB
87.23
44%
-104
- C3 -
2EQ7
3
?
A:
[2-449]
---
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
------
E
------
K
A
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
-
E
R
I
----
Y
E
A
K
--
K
G
L
--
L
G
A
K
V
-
K
-
G
-
V
E
L
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
--
G
V
E
F
L
F
K
K
N
G
I
A
R
H
Q
G
T
A
------
R
F
L
S
-----
E
R
-
K
V
L
V
-------------
E
---
E
TG-
E
E
L
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
W
A
Q
--
V
--
D
Y
---
E
R
V
V
T
S
T
E
A
L
S
F
P
-
E
-
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
-
T
-
M
D
L
E
V
S
R
A
A
E
R
V
F
K
K
-
Q
G
L
T
I
R
T
G
V
R
V
T
-
A
V
V
P
E
A
--
K
-
G
-
A
R
V
E
---
L
E
G
-----
G
E
V
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
-
S
L
E
N
-
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
-
G
-
P
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
R
G
F
G
--
H
V
--
D
Y
Q
A
I
P
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
S
L
S
E
I
L
K
E
A
A
L
A
A
W
E
R
P
110
HHSearch
85.77
41%
-103
- C3 -
2EQ6
2
?
A:
[4-456]
M
K
T
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
------
G
------
E
-
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
-
E
T
L
----
H
H
L
K
V
-
A
E
--
G
F
G
L
K
A
---
K
-
P
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
--
G
V
G
T
L
L
K
G
N
G
V
E
L
L
R
G
F
A
------
R
L
V
G
--
P
-
K
E
V
-
E
V
G
------------------
G
---
E
R
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
--
G
--
F
--
P
F
G--
E
D
V
W
D
S
T
R
A
L
K
V
E
E
G
-
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
-
Q
-
G
D
P
E
T
A
A
L
L
R
R
A
L
E
K
-
E
G
I
R
V
R
T
K
T
K
A
V
-
G
Y
E
K
K
K
--
D
-
G
-
L
H
V
R
---
L
E
P
A
E
G
G
E
G
E
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
-
G
L
E
K
-
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
-
P
-
P
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
S
--
A
F
--
D
Y
-
Q
V
P
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
15
PsiBlast_PDB
85.47
40%
-103
- C3 -
2EQ6
2
?
A:
[4-457]
M
K
T
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
------
G
------
E
V
-
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
-
E
T
L
----
H
H
L
K
--
V
A
-
E
G
F
G
L
K
A
-
K
-
P
--
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
--
G
V
G
T
L
L
K
G
N
G
V
E
L
L
R
G
F
A
------
R
L
V
G
P
K
E
------
V
E
V
-------------
G
---
G
---
E
R
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
--
F
--
G
E
----
D
V
W
D
S
T
R
A
L
K
V
E
-
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
-
Q
-
G
D
P
E
T
A
A
L
L
R
R
A
L
E
K
-
E
G
I
R
V
R
T
K
T
K
A
V
-
G
Y
E
K
K
K
--
D
-
G
-
L
H
V
R
---
L
E
P
A
E
G
G
E
G
E
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
-
G
L
E
K
-
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
-
P
-
P
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
S
--
A
F
--
D
Y
Q
V
-
P
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
-
E
A
F
H
K
Q
109
HHSearch
85.08
42%
-101
- C3 -
3LAD
2
DLDH_AZOVI
A:
[1-467]
S
Q
K
F
D
V
I
V
I
G
A
G
P
G
G
Y
V
A
A
I
K
S
A
Q
L
G
L
K
T
A
L
I
E
K
------
Y
KGKEGK
T
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
-
Y
K
F
----
H
E
A
H
--
E
S
F
K
L
H
G
I
S
T
-
G
-
E
-
V
A
I
D
V
P
T
M
I
A
R
K
D
Q
I
V
R
N
L
T
G
--
G
V
A
S
L
I
K
A
N
G
V
T
L
F
E
G
H
G
------
K
L
L
A
G
K
K
-
V
E
V
-
T
A
A
D
-------------
G
S--
S
---
Q
V
L
D
T
E
N
V
I
L
A
S
G
S
K
P
V
E
I
P
P
A
P
--
V
--
D
Q
---
D
V
I
V
D
S
T
G
A
L
D
F
Q
-
N
-
V
P
G
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
M
D
K
F
L
P
-
A
-
V
D
E
Q
V
A
K
E
A
Q
K
I
L
T
K
-
Q
G
L
K
I
L
L
G
A
R
V
T
-
G
T
E
V
K
N
--
K
-
Q
-
V
T
V
K
---
F
V
D
--
A
E
G
E
K
S
Q
A
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
-
L
A
A
D
-
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
Y
C
A
T
S
V
P
G
V
Y
A
I
G
D
V
V
R
-
G
-
A
M
L
A
H
K
A
S
E
E
G
V
V
V
A
E
R
I
A
G
H
K
A
--
Q
M
--
N
Y
D
L
I
P
A
V
I
Y
T
H
P
E
I
A
G
V
G
K
T
E
Q
A
L
K
A
E
G
V
A
I
N
V
G
V
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
A
G
F
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
A
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
A
H
P
A
L
S
E
A
L
H
E
A
A
L
A
V
S
G
H
A
75
PsiBlast_CBE
84.71
36%
-108
- C3 -
1EBD
2
DLDH1_GEOSE
B:
[5-451]
----
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
Q
K
V
T
I
V
E
K
------
G
------
N
L
-
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
S
A
S
-
H
R
Y
----
E
Q
A
K
--
H
S
-
E
E
M
G
I
K
A
-
E
-
N
-
V
T
I
D
F
A
K
V
Q
E
W
K
A
S
V
V
K
K
L
T
G
--
G
V
E
G
L
L
K
G
N
K
V
E
I
V
K
G
--------
E
A
Y
F
V
D
A
-
N
T
V
-
R
V
V
N
-------------
G
---
D
SA-
Q
T
Y
T
F
K
N
A
I
I
A
T
G
S
R
P
I
E
L
P
N
F
K
--
F
--
S
N
---
R
-
I
L
D
S
T
G
A
L
N
L
G
-
E
-
V
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
F
G
T
K
V
T
I
L
E
G
A
G
E
I
L
S
-
G
-
F
E
K
Q
M
A
A
I
I
K
K
R
L
K
K
-
K
G
V
E
V
V
T
N
A
L
A
K
-
G
A
E
E
R
E
--
D
-
G
-
V
T
V
T
---
Y
E
A
--
N
G
E
T
K
T
I
D
A
D
Y
V
L
V
T
V
G
R
R
P
N
T
D
E
L
-
G
L
E
Q
I
G
-
I
K
M
T
N
R
G
L
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
I
V
P
-
G
-
P
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
A
I
A
G
H
P
S
--
A
V
--
D
Y
V
A
I
P
A
V
V
F
S
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
I
D
V
I
A
A
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
P
N
A
S
D
M
I
A
E
L
G
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
I
H
A
H
P
T
L
G
E
I
A
M
E
A
A
E
V
A
L
---
18
PsiBlast_PDB
83.34
36%
-105
- C3 -
1EBD
2
DLDH1_GEOSE
A:
[5-451]
----
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
Q
K
V
T
I
V
E
K
------
G
------
N
L
-
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
S
A
S
-
H
R
Y
----
E
Q
A
K
--
H
S
-
E
E
M
G
I
K
A
-
E
-
N
-
V
T
I
D
F
A
K
V
Q
E
W
K
A
S
V
V
K
K
L
T
G
--
G
V
E
G
L
L
K
G
N
K
V
E
I
V
K
G
--------
E
A
Y
F
V
D
A
-
N
T
V
-
R
V
V
N
-------------
G
---
D
S
A
-
Q
T
Y
T
F
K
N
A
I
I
A
T
G
S
R
P
I
E
L
P
N
F
K
--
F
--
S
N
---
R
-
I
L
D
S
T
G
A
L
N
L
G
-
E
-
V
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
F
G
T
K
V
T
I
L
E
G
A
G
E
I
L
S
-
G
-
F
E
K
Q
M
A
A
I
I
K
K
R
L
K
K
-
K
G
V
E
V
V
T
N
A
L
A
K
-
G
A
E
E
R
E
--
D
-
G
-
V
T
V
T
---
Y
E
A
--
N
G
E
T
K
T
I
D
A
D
Y
V
L
V
T
V
G
R
R
P
N
T
D
E
L
-
G
L
E
Q
I
G
-
I
K
M
T
N
R
G
L
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
I
V
P
-
G
-
P
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
A
I
A
G
H
P
S
--
A
V
--
D
Y
V
A
I
P
A
V
V
F
S
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
I
D
V
I
A
A
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
P
N
A
S
D
M
I
A
E
L
G
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
I
H
A
H
P
T
L
G
E
I
A
M
E
A
A
E
V
A
L
---
116
HHSearch
81.22
36%
-100
- C3 -
1EBD
2
DLDH1_GEOSE
A:
[1-455]
A
I
E
T
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
Q
K
V
T
I
V
E
K
------
G
------
N
-
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
S
A
S
-
H
R
Y
----
E
Q
A
K
H
-
S
E
--
E
M
G
I
K
A
-
E
-
N
-
V
T
I
D
F
A
K
V
Q
E
W
K
A
S
V
V
K
K
L
T
G
--
G
V
E
G
L
L
K
G
N
K
V
E
I
V
K
G
E
A
------
Y
F
V
D
A
N
T
-
V
R
V
-
V
N
G
D
-------------
S
---
A
---
Q
T
Y
T
F
K
N
A
I
I
A
T
G
S
R
P
I
E
L
P
N
F
K
--
F
--
S
----
N
R
I
L
D
S
T
G
A
L
N
L
G
-
E
-
V
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
F
G
T
K
V
T
I
L
E
G
A
G
E
I
L
S
-
G
-
F
E
K
Q
M
A
A
I
I
K
K
R
L
K
K
-
K
G
V
E
V
V
T
N
A
L
A
K
-
G
A
E
E
R
E
--
D
-
G
-
V
T
V
T
---
Y
E
A
--
N
G
E
T
K
T
I
D
A
D
Y
V
L
V
T
V
G
R
R
P
N
T
D
E
L
-
G
L
E
Q
-
I
G
I
K
M
T
N
R
G
L
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
I
V
P
-
G
-
P
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
A
I
A
G
H
P
S
--
A
V
--
D
Y
V
A
I
P
A
V
V
F
S
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
I
D
V
I
A
A
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
P
N
A
S
D
M
I
A
E
L
G
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
I
H
A
H
P
T
L
G
E
I
A
M
E
A
A
E
V
A
L
---
101
HHSearch
80.83
34%
-100
- C3 -
1LVL
2
DLDH1_PSEPU
A:
[3-454]
T
I
Q
T
T
L
L
I
I
G
G
G
P
G
G
Y
V
A
A
I
R
A
G
Q
L
G
I
P
T
V
L
V
E
G
-------------
Q
A
L
G
G
T
C
L
N
I
G
C
I
P
S
K
A
L
I
H
V
A
-
E
Q
F
----
H
Q
A
S
R
F
T
E
P
S
P
L
G
I
S
V
-
A
-
S
-
P
R
L
D
I
G
Q
S
V
A
W
K
D
G
I
V
D
R
L
T
T
--
G
V
A
A
L
L
K
K
H
G
V
K
V
V
H
G
W
A
------
K
V
L
D
--
G
-
K
Q
V
-
E
V
D
------------------
G
---
Q
R
I
Q
C
E
H
L
L
L
A
T
G
S
S
S
V
E
L
P
M
L
P
--
L
--
G
----
G
P
V
I
S
S
T
E
A
L
A
P
K
-
A
-
L
P
Q
H
L
V
V
V
G
G
G
Y
I
G
L
E
L
G
I
A
Y
R
K
L
G
A
Q
V
S
V
V
E
A
R
E
R
I
L
P
-
T
-
Y
D
S
E
L
T
A
P
V
A
E
S
L
K
K
-
L
G
I
A
L
H
L
G
H
S
V
E
-
G
Y
E
N
G
--------
C
L
L
---
A
N
D
-
G
K
G
G
Q
L
R
L
E
A
D
R
V
L
V
A
V
G
R
R
P
R
T
K
G
F
-
N
L
E
C
-
L
D
L
K
M
N
-
G
A
A
I
A
I
D
E
R
C
Q
T
S
M
H
N
V
W
A
I
G
D
V
A
G
-
E
-
P
M
L
A
H
R
A
M
A
Q
G
E
M
V
A
E
I
I
A
G
K
A
R
--
R
F
--
E
P
A
A
I
A
A
V
C
F
T
D
P
E
V
V
V
V
G
K
T
P
E
Q
A
S
Q
Q
G
L
D
C
I
V
A
Q
F
P
F
A
A
N
G
R
A
M
S
L
E
S
K
S
G
F
V
R
V
V
A
R
R
D
N
H
L
I
L
G
W
Q
A
V
G
V
A
V
S
E
L
S
T
A
F
A
Q
S
L
E
M
G
A
C
L
E
D
V
A
G
T
I
H
A
H
P
T
L
G
E
A
V
Q
E
A
A
L
R
A
L
G
H
A
19
PsiBlast_PDB
80.28
35%
-104
- C3 -
4JDR
9
DLDH_ECOLI
A:
[9-451]
-----
V
V
V
L
G
A
G
P
A
G
Y
S
A
A
F
R
C
A
D
L
G
L
E
T
V
I
V
E
R
------
Y
------
N
T
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
H
V
A
--
K
V
----
I
E
E
A
--
K
A
L
A
E
H
G
I
V
F
-
G
-
E
-
P
K
T
D
I
D
K
I
R
T
W
K
E
K
V
I
N
Q
L
T
G
--
G
L
A
G
M
A
K
G
R
K
V
K
V
V
N
G
L
G
------
K
F
T
G
--
A
-
N
T
L
-
E
V
E
G
-------------
E
---
N
G
K
-
T
V
I
N
F
D
N
A
I
I
A
A
G
S
R
P
I
Q
L
P
F
I
P
--
H
--
E
D
---
P
R
I
W
D
S
T
D
A
L
E
L
K
-
E
-
V
P
E
R
L
L
V
M
G
G
G
I
I
G
L
E
M
G
T
V
Y
H
A
L
G
S
Q
I
D
V
V
E
M
F
D
Q
V
I
P
-
A
-
A
D
K
D
I
V
K
V
F
T
K
R
I
S
K
-
K
-
F
N
L
M
L
E
T
K
V
T
-
A
V
E
A
K
E
--
D
-
G
-
I
Y
V
T
---
M
E
G
-
K
K
A
P
A
E
P
Q
R
Y
D
A
V
L
V
A
I
G
R
V
P
N
G
K
N
L
-
D
A
G
K
-
A
G
V
E
V
D
D
R
G
F
I
R
V
D
K
Q
L
R
T
N
V
P
H
I
F
A
I
G
D
I
V
G
-
Q
-
P
M
L
A
H
K
G
V
H
E
G
H
V
A
A
E
V
I
A
G
K
K
H
--
Y
F
--
D
P
K
V
I
P
S
I
A
Y
T
E
P
E
V
A
W
V
G
L
T
E
K
E
A
K
E
K
G
I
S
Y
E
T
A
T
F
P
W
A
A
S
G
R
A
I
A
S
D
C
A
D
G
M
T
K
L
I
F
D
K
E
S
H
R
V
I
G
G
A
I
V
G
T
N
G
G
E
L
L
G
E
I
G
L
A
I
E
M
G
C
D
A
E
D
I
A
L
T
I
H
A
H
P
T
L
H
E
S
V
G
L
A
A
E
V
F
E
G
S
I
81
PsiBlast_CBE
80.18
35%
-104
- C3 -
4JDR
5
DLDH_ECOLI
B:
[9-451]
-----
V
V
V
L
G
A
G
P
A
G
Y
S
A
A
F
R
C
A
D
L
G
L
E
T
V
I
V
E
R
------
Y
------
N
T
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
H
V
A
--
K
V
----
I
E
E
A
--
K
A
L
A
E
H
G
I
V
F
-
G
-
E
-
P
K
T
D
I
D
K
I
R
T
W
K
E
K
V
I
N
Q
L
T
G
--
G
L
A
G
M
A
K
G
R
K
V
K
V
V
N
G
L
G
------
K
F
T
G
--
A
-
N
T
L
-
E
V
E
G
-------------
E
---
N
GK-
T
V
I
N
F
D
N
A
I
I
A
A
G
S
R
P
I
Q
L
P
F
I
P
--
H
--
E
D
---
P
R
I
W
D
S
T
D
A
L
E
L
K
-
E
-
V
P
E
R
L
L
V
M
G
G
G
I
I
G
L
E
M
G
T
V
Y
H
A
L
G
S
Q
I
D
V
V
E
M
F
D
Q
V
I
P
-
A
-
A
D
K
D
I
V
K
V
F
T
K
R
I
S
K
-
K
-
F
N
L
M
L
E
T
K
V
T
-
A
V
E
A
K
E
--
D
-
G
-
I
Y
V
T
---
M
E
G
-
K
K
A
P
A
E
P
Q
R
Y
D
A
V
L
V
A
I
G
R
V
P
N
G
K
N
L
-
D
A
G
K
-
A
G
V
E
V
D
D
R
G
F
I
R
V
D
K
Q
L
R
T
N
V
P
H
I
F
A
I
G
D
I
V
G
-
Q
-
P
M
L
A
H
K
G
V
H
E
G
H
V
A
A
E
V
I
A
G
K
K
H
--
Y
F
--
D
P
K
V
I
P
S
I
A
Y
T
E
P
E
V
A
W
V
G
L
T
E
K
E
A
K
E
K
G
I
S
Y
E
T
A
T
F
P
W
A
A
S
G
R
A
I
A
S
D
C
A
D
G
M
T
K
L
I
F
D
K
E
S
H
R
V
I
G
G
A
I
V
G
T
N
G
G
E
L
L
G
E
I
G
L
A
I
E
M
G
C
D
A
E
D
I
A
L
T
I
H
A
H
P
T
L
H
E
S
V
G
L
A
A
E
V
F
E
G
S
I
82
PsiBlast_CBE
79.42
34%
-100
- C3 -
1LVL
2
DLDH1_PSEPU
A:
[8-452]
-----
L
L
I
I
G
G
G
P
G
G
Y
V
A
A
I
R
A
G
Q
L
G
I
P
T
V
L
V
E
G
------
Q
------
A
L
-
G
G
T
C
L
N
I
G
C
I
P
S
K
A
L
I
H
V
A
-
E
Q
F
H
Q
A
S
R
F
T
E
--
P
S
--
P
L
G
I
S
V
-
A
-
S
-
P
R
L
D
I
G
Q
S
V
A
W
K
D
G
I
V
D
R
L
T
T
--
G
V
A
A
L
L
K
K
H
G
V
K
V
V
H
G
W
A
------
K
V
L
-----
D
G
K
-
Q
V
E
V
-------------
D
---
G
---
Q
R
I
Q
C
E
H
L
L
L
A
T
G
S
S
S
V
E
L
P
M
L
P
--
L
--
G
----
G
P
V
I
S
S
T
E
A
L
A
P
K
-
A
-
L
P
Q
H
L
V
V
V
G
G
G
Y
I
G
L
E
L
G
I
A
Y
R
K
L
G
A
Q
V
S
V
V
E
A
R
E
R
I
L
P
-
T
-
Y
D
S
E
L
T
A
P
V
A
E
S
L
K
K
-
L
G
I
A
L
H
L
G
H
S
V
E
-
G
Y
-
E
N
G
--
C
-
L
-
L
A
------
N
D
G
K
G
G
Q
L
R
-
L
E
A
D
R
V
L
V
A
V
G
R
R
P
R
T
K
G
F
-
N
L
E
C
-
L
-
D
L
K
M
N
G
A
A
I
A
I
D
E
R
C
Q
T
S
M
H
N
V
W
A
I
G
D
V
A
G
-
E
-
P
M
L
A
H
R
A
M
A
Q
G
E
M
V
A
E
I
I
A
G
K
A
R
--
R
F
--
E
P
A
A
I
A
A
V
C
F
T
D
P
E
V
V
V
V
G
K
T
P
E
Q
A
S
Q
Q
G
L
D
C
I
V
A
Q
F
P
F
A
A
N
G
R
A
M
S
L
E
S
K
S
G
F
V
R
V
V
A
R
R
D
N
H
L
I
L
G
W
Q
A
V
G
V
A
V
S
E
L
S
T
A
F
A
Q
S
L
E
M
G
A
C
L
E
D
V
A
G
T
I
H
A
H
P
T
L
G
E
A
V
Q
E
A
A
L
R
A
L
G
H
A
114
HHSearch
79.34
33%
-99
- C3 -
2A8X
3
DLDH_MYCTU
A:
[1-460]
M
T
H
Y
D
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
S
T
A
I
V
E
P
------
K
-------
Y
W
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
R
N
A
-
E
L
V
----
H
I
F
T
--
K
D
A
K
A
F
G
I
S
G
---
E
-
V
T
F
D
Y
G
I
A
Y
D
R
S
R
K
V
A
E
G
R
V
A
--
G
V
H
F
L
M
K
K
N
K
I
T
E
I
H
G
Y
G
------
T
F
A
D
A
N
T
-
L
L
V
-
D
L
N
D
-------------
G
G
--
T
---
E
S
V
T
F
D
N
A
I
I
A
T
G
S
S
T
R
L
V
P
G
T
S
--
L
--
S
----
A
N
V
V
T
Y
E
E
Q
I
L
S
R
-
E
-
L
P
K
S
I
I
I
A
G
A
G
A
I
G
M
E
F
G
Y
V
L
K
N
Y
G
V
D
V
T
I
V
E
F
L
P
R
A
L
P
-
N
-
E
D
A
D
V
S
K
E
I
E
K
Q
F
K
K
-
L
G
V
T
I
L
T
A
T
K
V
E
-
S
I
A
D
G
G
--
S
-
Q
-
V
T
V
T
---
V
T
--
K
D
G
V
A
Q
E
L
K
A
E
K
V
L
Q
A
I
G
F
A
P
N
V
E
G
Y
-
G
L
D
K
-
A
G
V
A
L
T
D
R
K
A
I
G
V
D
D
Y
M
R
T
N
V
G
H
I
Y
A
I
G
D
V
N
G
-
L
-
L
Q
L
A
H
V
A
E
A
Q
G
V
V
A
A
E
T
I
A
G
A
E
T
L
T
L
G
--
D
H
R
M
L
P
R
A
T
F
C
Q
P
N
V
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
Y
D
V
V
V
A
K
F
P
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
D
V
A
E
L
L
P
E
L
T
L
A
Q
R
W
D
L
T
A
S
E
L
A
R
N
V
H
T
H
P
T
M
S
E
A
L
Q
E
C
F
H
G
L
V
G
H
M
106
HHSearch
79.19
36%
-98
- C3 -
1OJT
1
?
A:
[5-473]
-
A
E
Y
D
V
V
V
L
G
G
G
P
G
G
Y
S
A
A
F
A
A
A
D
E
G
L
K
V
A
I
V
E
R
------
Y
------
K
T
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
H
N
A
-
A
V
I
----
D
E
V
R
---
H
L
A
A
N
G
I
K
Y
-
P
-
E
-
P
E
L
D
I
D
M
L
R
A
Y
K
D
G
V
V
S
R
L
T
G
--
G
L
A
G
M
A
K
S
R
K
V
D
V
I
Q
G
D
G
------
Q
F
L
D
P
H
H
-
L
E
V
-
S
L
T
A
G
DAYE
Q
A
A
P
TG--
E
---
K
---
K
I
V
A
F
K
N
C
I
I
A
A
G
S
R
V
T
K
L
P
F
----
I
--
P
E
D
--
P
R
I
I
D
S
S
G
A
L
A
L
K
-
E
-
V
P
G
K
L
L
I
I
G
G
G
I
I
G
L
E
M
G
T
V
Y
S
T
L
G
S
R
L
D
V
V
E
M
M
D
G
L
M
Q
-
G
-
A
D
R
D
L
V
K
V
W
Q
K
Q
N
E
Y
-
R
F
D
N
I
M
V
N
T
K
T
V
-
A
V
E
P
K
E
--
D
-
G
-
V
Y
V
T
---
F
E
G
A
-
N
A
P
K
E
P
Q
R
Y
D
A
V
L
V
A
A
G
R
A
P
N
G
K
L
I
-
S
A
E
K
-
A
G
V
A
V
T
D
R
G
F
I
E
V
D
K
Q
M
R
T
N
V
P
H
I
Y
A
I
G
D
I
V
G
-
Q
-
P
M
L
A
H
K
A
V
H
E
G
H
V
A
A
E
N
C
A
G
H
K
A
--
Y
F
--
D
A
R
V
I
P
G
V
A
Y
T
S
P
E
V
A
W
V
G
E
T
E
L
S
A
K
A
S
A
R
K
I
T
K
A
N
F
P
W
A
A
S
G
R
A
I
A
N
G
C
D
K
P
F
T
K
L
I
F
D
A
E
T
G
R
I
I
G
G
G
I
V
G
P
N
G
G
D
M
I
G
E
V
C
L
A
I
E
M
G
C
D
A
A
D
I
G
K
T
I
H
P
H
P
T
L
G
E
S
I
G
M
A
A
E
V
A
L
G
T
C
88
PsiBlast_CBE
77.32
34%
-96
- C3 -
3II4
3
DLDH_MYCTU
A:
[4-454]
-
T
H
Y
D
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
S
T
A
I
V
E
P
------
K
-------
Y
W
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
R
N
A
E
L
V
H
----
I
F
T
K
--
D
A
-
K
A
F
G
I
-
S
-
G
-
E
-
V
T
F
D
Y
G
--
I
A
Y
D
R
S
R
K
V
A
E
G
R
V
A
G
V
H
F
L
M
K
K
N
K
I
T
E
I
H
G
Y
G
--------
T
F
A
D
A
-
N
T
L
-
L
V
D
L
-------------
N
---
D
G
G
T
E
S
V
T
F
D
N
A
I
I
A
T
G
S
S
T
R
L
V
P
G
T
S
--
L
--
S
----
A
N
V
V
T
Y
E
E
Q
I
L
S
R
-
E
-
L
P
K
S
I
I
I
A
G
A
G
A
I
G
M
E
F
G
Y
V
L
K
N
Y
G
V
D
V
T
I
V
E
F
L
P
R
A
L
P
-
N
-
E
D
A
D
V
S
K
E
I
E
K
Q
F
K
K
-
L
G
V
T
I
L
T
A
T
K
V
E
-
S
I
A
D
G
G
--
S
-
Q
-
V
T
V
T
---
V
T
--
K
D
G
V
A
Q
E
L
K
A
E
K
V
L
Q
A
I
G
F
A
P
N
V
E
G
Y
-
G
L
D
K
-
A
G
V
A
L
T
D
R
K
A
I
G
V
D
D
Y
M
R
T
N
V
G
H
I
Y
A
I
G
D
V
N
G
-
L
-
L
Q
L
A
H
V
A
E
A
Q
G
V
V
A
A
E
T
I
A
G
A
E
T
--
L
T
LG
D
H
R
M
L
P
R
A
T
F
C
Q
P
N
V
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
Y
D
V
V
V
A
K
F
P
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
D
V
A
E
L
L
P
E
L
T
L
A
Q
R
W
D
L
T
A
S
E
L
A
R
N
V
H
T
H
P
T
M
S
E
A
L
Q
E
C
F
H
G
L
V
G
H
M
89
PsiBlast_CBE
72.90
35%
-97
- C3 -
1OJT
1
?
A:
[19-463]
---------------
Y
S
A
A
F
A
A
A
D
E
G
L
K
V
A
I
V
E
R
------
Y
------
K
T
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
H
N
A
--
A
V
----
I
D
E
V
--
R
H
L
A
A
N
G
I
K
Y
-
P
-
E
-
P
E
L
D
I
D
M
L
R
A
Y
K
D
G
V
V
S
R
L
T
G
--
G
L
A
G
M
A
K
S
R
K
V
D
V
I
Q
G
D
G
------
Q
F
--
L
D
P
-
H
H
L
-
E
V
S
L
T
A
G
DAYE
Q
A
A
P
TG
E
---
K
---
K
I
V
A
F
K
N
C
I
I
A
A
G
S
R
V
T
K
L
P
F
I
P
--
E
--
D
P
---
R
-
I
I
D
S
S
G
A
L
A
L
K
-
E
-
V
P
G
K
L
L
I
I
G
G
G
I
I
G
L
E
M
G
T
V
Y
S
T
L
G
S
R
L
D
V
V
E
M
M
D
G
L
M
Q
-
G
-
A
D
R
D
L
V
K
V
W
Q
K
Q
N
E
Y
-
R
F
D
N
I
M
V
N
T
K
T
V
-
A
V
E
P
K
E
--
D
-
G
-
V
Y
V
T
F
E
G
A
N
A
P
K
E
P
Q
----
R
Y
D
A
V
L
V
A
A
G
R
A
P
N
G
K
L
I
-
S
A
E
K
-
A
G
V
A
V
T
D
R
G
F
I
E
V
D
K
Q
M
R
T
N
V
P
H
I
Y
A
I
G
D
I
V
G
-
Q
-
P
M
L
A
H
K
A
V
H
E
G
H
V
A
A
E
N
C
A
G
H
K
A
--
Y
F
--
D
A
R
V
I
P
G
V
A
Y
T
S
P
E
V
A
W
V
G
E
T
E
L
S
A
K
A
S
A
R
K
I
T
K
A
N
F
P
W
A
A
S
G
R
A
I
A
N
G
C
D
K
P
F
T
K
L
I
F
D
A
E
T
G
R
I
I
G
G
G
I
V
G
P
N
G
G
D
M
I
G
E
V
C
L
A
I
E
M
G
C
D
A
A
D
I
G
K
T
I
H
P
H
P
T
L
G
E
S
I
G
M
A
A
E
V
A
L
G
T
C
90
PsiBlast_CBE
72.00
35%
-93
- C3 -
1BHY
1
?
A:
[19-462]
---------------
Y
S
A
A
F
A
A
A
D
E
G
L
K
V
A
I
V
E
R
------
Y
------
K
T
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
H
N
A
--
A
V
----
I
D
E
V
--
R
H
L
A
A
N
G
I
K
Y
-
P
-
E
-
P
E
L
D
I
D
M
L
R
A
Y
K
D
G
V
V
S
R
L
T
G
--
G
L
A
G
M
A
K
S
R
K
V
D
V
I
Q
G
D
G
------
Q
F
--
L
D
P
-
H
H
L
-
E
V
S
L
T
A
G
DAYE
Q
A
A
P
TG
E
---
K
---
K
I
V
A
F
K
N
C
I
I
A
A
G
S
R
V
T
K
L
P
F
I
P
--
E
--
D
P
---
R
-
I
I
D
S
S
G
A
L
A
L
K
-
E
-
V
P
G
K
L
L
I
I
G
G
G
I
I
G
L
E
M
G
T
V
Y
S
T
L
G
S
R
L
D
V
V
E
M
M
D
G
L
M
Q
-
G
-
A
D
R
D
L
V
K
V
W
Q
K
Q
N
E
Y
-
R
F
D
N
I
M
V
N
T
K
T
V
-
A
V
E
P
K
E
--
D
-
G
-
V
Y
V
T
F
E
G
A
N
A
P
K
E
P
Q
----
R
Y
D
A
V
L
V
A
A
G
R
A
P
N
G
K
L
I
-
S
A
E
K
-
A
G
V
A
V
T
D
R
G
F
I
E
V
D
K
Q
M
R
T
N
V
P
H
I
Y
A
I
G
D
I
V
G
-
Q
-
P
M
L
A
H
K
A
V
H
E
G
H
V
A
A
E
N
C
A
G
H
K
A
--
Y
F
--
D
A
R
V
I
P
G
V
A
Y
T
S
P
E
V
A
W
V
G
E
T
E
L
S
A
K
A
S
A
R
K
I
T
K
A
N
F
P
W
A
A
S
G
R
A
I
A
N
G
C
D
K
P
F
T
K
L
I
F
D
A
E
T
G
R
I
I
G
G
G
I
V
G
P
N
G
G
D
M
I
G
E
V
Y
L
A
I
E
M
G
C
D
A
A
D
I
G
K
T
I
H
P
H
P
T
L
G
E
S
I
G
M
A
A
E
V
A
L
G
T
C